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Utkan Demirci, PH.D.

TitleAssociate Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressPartners Research Building
Renal Division-Rm 267
65 Landsdowne St
Cambridge MA 02139

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wang S, Tasoglu S, Chen PZ, Chen M, Akbas R, Wach S, Ozdemir CI, Gurkan UA, Giguel FF, Kuritzkes DR, Demirci U. Micro-a-fluidics ELISA for Rapid CD4 Cell Count at the Point-of-Care. Sci Rep. 2014; 4:3796.
    View in: PubMed
  2. Tasoglu S, Gurkan UA, Wang S, Demirci U. Manipulating biological agents and cells in micro-scale volumes for applications in medicine. Chem Soc Rev. 2013 Jul 7; 42(13):5788-808.
    View in: PubMed
  3. Durmus NG, Tasoglu S, Demirci U. Bioprinting: Functional droplet networks. Nat Mater. 2013 Jun; 12(6):478-9.
    View in: PubMed
  4. Inci F, Tokel O, Wang S, Gurkan UA, Tasoglu S, Kuritzkes DR, Demirci U. Nanoplasmonic quantitative detection of intact viruses from unprocessed whole blood. ACS Nano. 2013 Jun 25; 7(6):4733-45.
    View in: PubMed
  5. Tasoglu S, Safaee H, Zhang X, Kingsley JL, Catalano PN, Gurkan UA, Nureddin A, Kayaalp E, Anchan RM, Maas RL, Tüzel E, Demirci U. Exhaustion of racing sperm in nature-mimicking microfluidic channels during sorting. Small. 2013 Oct 25; 9(20):3374-84.
    View in: PubMed
  6. Rizvi I, Gurkan UA, Tasoglu S, Alagic N, Celli JP, Mensah LB, Mai Z, Demirci U, Hasan T. Flow induces epithelial-mesenchymal transition, cellular heterogeneity and biomarker modulation in 3D ovarian cancer nodules. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):E1974-83.
    View in: PubMed
  7. Shafiee H, Jahangir M, Inci F, Wang S, Willenbrecht RB, Giguel FF, Tsibris AM, Kuritzkes DR, Demirci U. Acute On-Chip HIV Detection Through Label-Free Electrical Sensing of Viral Nano-Lysate. Small. 2013 Aug 12; 9(15):2553-63.
    View in: PubMed
  8. Wang S, Inci F, De Libero G, Singhal A, Demirci U. Point-of-care assays for tuberculosis: Role of nanotechnology/microfluidics. Biotechnol Adv. 2013 Jul; 31(4):438-49.
    View in: PubMed
  9. Tasoglu S, Demirci U. Bioprinting for stem cell research. Trends Biotechnol. 2013 Jan; 31(1):10-9.
    View in: PubMed
  10. Tasoglu S, Kavaz D, Gurkan UA, Guven S, Chen P, Zheng R, Demirci U. Paramagnetic levitational assembly of hydrogels. Adv Mater. 2013 Feb 25; 25(8):1137-43.
    View in: PubMed
  11. Guven S, Demirci U. Integrating nanoscale technologies with cryogenics: a step towards improved biopreservation. Nanomedicine (Lond). 2012 Dec; 7(12):1787-9.
    View in: PubMed
  12. Gurkan UA, Fan Y, Xu F, Erkmen B, Urkac ES, Parlakgul G, Bernstein J, Xing W, Boyden ES, Demirci U. Simple precision creation of digitally specified, spatially heterogeneous, engineered tissue architectures. Adv Mater. 2013 Feb 25; 25(8):1192-8.
    View in: PubMed
  13. Ceyhan E, Xu F, Gurkan UA, Emre AE, Turali ES, El Assal R, Acikgenc A, Wu CA, Demirci U. Prediction and control of number of cells in microdroplets by stochastic modeling. Lab Chip. 2012 Nov 21; 12(22):4884-93.
    View in: PubMed
  14. Wang S, Sarenac D, Chen MH, Huang SH, Giguel FF, Kuritzkes DR, Demirci U. Simple filter microchip for rapid separation of plasma and viruses from whole blood. Int J Nanomedicine. 2012; 7:5019-28.
    View in: PubMed
  15. Xu F, Inci F, Mullick O, Gurkan UA, Sung Y, Kavaz D, Li B, Denkbas EB, Demirci U. Release of magnetic nanoparticles from cell-encapsulating biodegradable nanobiomaterials. ACS Nano. 2012 Aug 28; 6(8):6640-9.
    View in: PubMed
  16. Gurkan UA, Tasoglu S, Akkaynak D, Avci O, Unluisler S, Canikyan S, Maccallum N, Demirci U. Smart interface materials integrated with microfluidics for on-demand local capture and release of cells. Adv Healthc Mater. 2012 Sep; 1(5):661-8.
    View in: PubMed
  17. Wang S, Inci F, Chaunzwa TL, Ramanujam A, Vasudevan A, Subramanian S, Chi Fai Ip A, Sridharan B, Gurkan UA, Demirci U. Portable microfluidic chip for detection of Escherichia coli in produce and blood. Int J Nanomedicine. 2012; 7:2591-600.
    View in: PubMed
  18. Wang S, Esfahani M, Gurkan UA, Inci F, Kuritzkes DR, Demirci U. Efficient on-chip isolation of HIV subtypes. Lab Chip. 2012 Apr 21; 12(8):1508-15.
    View in: PubMed
  19. Gurkan UA, Tasoglu S, Kavaz D, Demirel MC, Demirci U. Emerging technologies for assembly of microscale hydrogels. Adv Healthc Mater. 2012 Mar; 1(2):149-58.
    View in: PubMed
  20. Guldiken R, Jo MC, Gallant ND, Demirci U, Zhe J. Sheathless size-based acoustic particle separation. Sensors (Basel). 2012; 12(1):905-22.
    View in: PubMed
  21. Zhang X, Khimji I, Shao L, Safaee H, Desai K, Keles HO, Gurkan UA, Kayaalp E, Nureddin A, Anchan RM, Maas RL, Demirci U. Nanoliter droplet vitrification for oocyte cryopreservation. Nanomedicine (Lond). 2012 Apr; 7(4):553-64.
    View in: PubMed
  22. Gurkan UA, Anand T, Tas H, Elkan D, Akay A, Keles HO, Demirci U. Controlled viable release of selectively captured label-free cells in microchannels. Lab Chip. 2011 Dec 7; 11(23):3979-89.
    View in: PubMed
  23. Wang S, Zhao X, Khimji I, Akbas R, Qiu W, Edwards D, Cramer DW, Ye B, Demirci U. Integration of cell phone imaging with microchip ELISA to detect ovarian cancer HE4 biomarker in urine at the point-of-care. Lab Chip. 2011 Oct 21; 11(20):3411-8.
    View in: PubMed
  24. Xu F, Wu CA, Rengarajan V, Finley TD, Keles HO, Sung Y, Li B, Gurkan UA, Demirci U. Three-dimensional magnetic assembly of microscale hydrogels. Adv Mater. 2011 Oct 4; 23(37):4254-60.
    View in: PubMed
  25. Xu F, Finley TD, Turkaydin M, Sung Y, Gurkan UA, Yavuz AS, Guldiken RO, Demirci U. The assembly of cell-encapsulating microscale hydrogels using acoustic waves. Biomaterials. 2011 Nov; 32(31):7847-55.
    View in: PubMed
  26. Zhang X, Catalano PN, Gurkan UA, Khimji I, Demirci U. Emerging technologies in medical applications of minimum volume vitrification. Nanomedicine (Lond). 2011 Aug; 6(6):1115-29.
    View in: PubMed
  27. Moon S, Ceyhan E, Gurkan UA, Demirci U. Statistical modeling of single target cell encapsulation. PLoS One. 2011; 6(7):e21580.
    View in: PubMed
  28. Moon S, Gurkan UA, Blander J, Fawzi WW, Aboud S, Mugusi F, Kuritzkes DR, Demirci U. Enumeration of CD4+ T-cells using a portable microchip count platform in Tanzanian HIV-infected patients. PLoS One. 2011; 6(7):e21409.
    View in: PubMed
  29. Xu F, Wu J, Wang S, Durmus NG, Gurkan UA, Demirci U. Microengineering methods for cell-based microarrays and high-throughput drug-screening applications. Biofabrication. 2011 Sep; 3(3):034101.
    View in: PubMed
  30. Xu F, Sridharan B, Wang S, Gurkan UA, Syverud B, Demirci U. Embryonic stem cell bioprinting for uniform and controlled size embryoid body formation. Biomicrofluidics. 2011 Jun; 5(2):22207.
    View in: PubMed
  31. Zhang X, Khimji I, Gurkan UA, Safaee H, Catalano PN, Keles HO, Kayaalp E, Demirci U. Lensless imaging for simultaneous microfluidic sperm monitoring and sorting. Lab Chip. 2011 Aug 7; 11(15):2535-40.
    View in: PubMed
  32. Xu F, Sridharan B, Durmus NG, Wang S, Yavuz AS, Gurkan UA, Demirci U. Living bacterial sacrificial porogens to engineer decellularized porous scaffolds. PLoS One. 2011; 6(4):e19344.
    View in: PubMed
  33. Xu F, Beyazoglu T, Hefner E, Gurkan UA, Demirci U. Automated and adaptable quantification of cellular alignment from microscopic images for tissue engineering applications. Tissue Eng Part C Methods. 2011 Jun; 17(6):641-9.
    View in: PubMed
  34. Moon S, Kim YG, Dong L, Lombardi M, Haeggstrom E, Jensen RV, Hsiao LL, Demirci U. Drop-on-demand single cell isolation and total RNA analysis. PLoS One. 2011; 6(3):e17455.
    View in: PubMed
  35. Samot J, Moon S, Shao L, Zhang X, Xu F, Song Y, Keles HO, Matloff L, Markel J, Demirci U. Blood banking in living droplets. PLoS One. 2011; 6(3):e17530.
    View in: PubMed
  36. Demirci U, Geckil H. Editorial: Micro and nanofluidics - applications in biotechnology. Biotechnol J. 2011 Feb; 6(2):131.
    View in: PubMed
  37. Xu F, Celli J, Rizvi I, Moon S, Hasan T, Demirci U. A three-dimensional in vitro ovarian cancer coculture model using a high-throughput cell patterning platform. Biotechnol J. 2011 Feb; 6(2):204-12.
    View in: PubMed
  38. Gurkan UA, Moon S, Geckil H, Xu F, Wang S, Lu TJ, Demirci U. Miniaturized lensless imaging systems for cell and microorganism visualization in point-of-care testing. Biotechnol J. 2011 Feb; 6(2):138-49.
    View in: PubMed
  39. Wang S, Xu F, Demirci U. Advances in developing HIV-1 viral load assays for resource-limited settings. Biotechnol Adv. 2010 Nov-Dec; 28(6):770-81.
    View in: PubMed
  40. Park JH, Chung BG, Lee WG, Kim J, Brigham MD, Shim J, Lee S, Hwang CM, Durmus NG, Demirci U, Khademhosseini A. Microporous cell-laden hydrogels for engineered tissue constructs. Biotechnol Bioeng. 2010 May 1; 106(1):138-48.
    View in: PubMed
  41. Geckil H, Xu F, Zhang X, Moon S, Demirci U. Engineering hydrogels as extracellular matrix mimics. Nanomedicine (Lond). 2010 Apr; 5(3):469-84.
    View in: PubMed
  42. Xu F, Moon SJ, Emre AE, Turali ES, Song YS, Hacking SA, Nagatomi J, Demirci U. A droplet-based building block approach for bladder smooth muscle cell (SMC) proliferation. Biofabrication. 2010 Mar; 2(1):014105.
    View in: PubMed
  43. Song YS, Adler D, Xu F, Kayaalp E, Nureddin A, Anchan RM, Maas RL, Demirci U. Vitrification and levitation of a liquid droplet on liquid nitrogen. Proc Natl Acad Sci U S A. 2010 Mar 9; 107(10):4596-600.
    View in: PubMed
  44. Xu F, Moon S, Zhang X, Shao L, Song YS, Demirci U. Multi-scale heat and mass transfer modelling of cell and tissue cryopreservation. Philos Transact A Math Phys Eng Sci. 2010 Feb 13; 368(1912):561-83.
    View in: PubMed
  45. Moon S, Hasan SK, Song YS, Xu F, Keles HO, Manzur F, Mikkilineni S, Hong JW, Nagatomi J, Haeggstrom E, Khademhosseini A, Demirci U. Layer by layer three-dimensional tissue epitaxy by cell-laden hydrogel droplets. Tissue Eng Part C Methods. 2010 Feb; 16(1):157-66.
    View in: PubMed
  46. Lee WG, Kim YG, Chung BG, Demirci U, Khademhosseini A. Nano/Microfluidics for diagnosis of infectious diseases in developing countries. Adv Drug Deliv Rev. 2010 Mar 18; 62(4-5):449-57.
    View in: PubMed
  47. Alyassin MA, Moon S, Keles HO, Manzur F, Lin RL, Hæggstrom E, Kuritzkes DR, Demirci U. Rapid automated cell quantification on HIV microfluidic devices. Lab Chip. 2009 Dec 7; 9(23):3364-9.
    View in: PubMed
  48. Song YS, Lin RL, Montesano G, Durmus NG, Lee G, Yoo SS, Kayaalp E, Haeggström E, Khademhosseini A, Demirci U. Engineered 3D tissue models for cell-laden microfluidic channels. Anal Bioanal Chem. 2009 Sep; 395(1):185-93.
    View in: PubMed
  49. Kim YG, Moon S, Kuritzkes DR, Demirci U. Quantum dot-based HIV capture and imaging in a microfluidic channel. Biosens Bioelectron. 2009 Sep 15; 25(1):253-8.
    View in: PubMed
  50. Moon S, Keles HO, Ozcan A, Khademhosseini A, Haeggstrom E, Kuritzkes D, Demirci U. Integrating microfluidics and lensless imaging for point-of-care testing. Biosens Bioelectron. 2009 Jul 15; 24(11):3208-14.
    View in: PubMed
  51. Song YS, Moon S, Hulli L, Hasan SK, Kayaalp E, Demirci U. Microfluidics for cryopreservation. Lab Chip. 2009 Jul 7; 9(13):1874-81.
    View in: PubMed
  52. Lee WG, Demirci U, Khademhosseini A. Microscale electroporation: challenges and perspectives for clinical applications. Integr Biol (Camb). 2009 Mar; 1(3):242-51.
    View in: PubMed
  53. Moon S, Keles HO, Kim YG, Kuritzkes D, Demirci U. Lensless imaging for point-of-care testing. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:6376-9.
    View in: PubMed
  54. Manbachi A, Shrivastava S, Cioffi M, Chung BG, Moretti M, Demirci U, Yliperttula M, Khademhosseini A. Microcirculation within grooved substrates regulates cell positioning and cell docking inside microfluidic channels. Lab Chip. 2008 May; 8(5):747-54.
    View in: PubMed
  55. Ozcan A, Demirci U. Ultra wide-field lens-free monitoring of cells on-chip. Lab Chip. 2008 Jan; 8(1):98-106.
    View in: PubMed
  56. Demirci U. Using micro-electro-mechanical systems (MEMS) to develop diagnostic tools. J Vis Exp. 2007; (8):314.
    View in: PubMed
  57. Moon S, Lin PA, Keles HO, Yoo SS, Demirci U. Title cell encapsulation by droplets. J Vis Exp. 2007; (8):316.
    View in: PubMed
  58. Moon SJ, Lin R, Demirci U. CD4+ T-lymphocyte capture using a disposable microfluidic chip for HIV. J Vis Exp. 2007; (8):315.
    View in: PubMed
  59. Demirci U, Montesano G. Cell encapsulating droplet vitrification. Lab Chip. 2007 Nov; 7(11):1428-33.
    View in: PubMed
  60. Demirci U, Montesano G. Single cell epitaxy by acoustic picolitre droplets. Lab Chip. 2007 Sep; 7(9):1139-45.
    View in: PubMed
  61. Cheng X, Irimia D, Dixon M, Ziperstein JC, Demirci U, Zamir L, Tompkins RG, Toner M, Rodriguez WR. A microchip approach for practical label-free CD4+ T-cell counting of HIV-infected subjects in resource-poor settings. J Acquir Immune Defic Syndr. 2007 Jul 1; 45(3):257-61.
    View in: PubMed
  62. Cheng X, Liu YS, Irimia D, Demirci U, Yang L, Zamir L, Rodríguez WR, Toner M, Bashir R. Cell detection and counting through cell lysate impedance spectroscopy in microfluidic devices. Lab Chip. 2007 Jun; 7(6):746-55.
    View in: PubMed
  63. Ling Y, Rubin J, Deng Y, Huang C, Demirci U, Karp JM, Khademhosseini A. A cell-laden microfluidic hydrogel. Lab Chip. 2007 Jun; 7(6):756-62.
    View in: PubMed
  64. Cheng X, Irimia D, Dixon M, Sekine K, Demirci U, Zamir L, Tompkins RG, Rodriguez W, Toner M. A microfluidic device for practical label-free CD4(+) T cell counting of HIV-infected subjects. Lab Chip. 2007 Feb; 7(2):170-8.
    View in: PubMed
  65. Johnson JA, Oralkan O, Ergun S, Demirci U, Karaman M, Khuri-Yakub BT. Coherent array imaging using phased subarrays. Part II: simulations and experimental results. IEEE Trans Ultrason Ferroelectr Freq Control. 2005 Jan; 52(1):51-64.
    View in: PubMed
  66. Demirci U, Ergun AS, Oralkan O, Karaman M, Khuri-Yakub BT. Forward-viewing CMUT arrays for medical imaging. IEEE Trans Ultrason Ferroelectr Freq Control. 2004 Jul; 51(7):887-95.
    View in: PubMed
  67. Oralkan O, Ergun AS, Johnson JA, Karaman M, Demirci U, Kaviani K, Lee TH, Khuri-Yakub BT. Capacitive micromachined ultrasonic transducers: next-generation arrays for acoustic imaging? IEEE Trans Ultrason Ferroelectr Freq Control. 2002 Nov; 49(11):1596-610.
    View in: PubMed
  68. Johnson J, Oralkan O, Demirci U, Ergun S, Karaman M, Khuri-Yakub P. Medical imaging using capacitive micromachined ultrasonic transducer arrays. Ultrasonics. 2002 May; 40(1-8):471-6.
    View in: PubMed
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