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R. John Collier, Ph.D.

TitleMaude and Lillian Presley Professor of Microbiology and Immunobiology, Emeritus
InstitutionHarvard Medical School
DepartmentEmeritus
AddressHarvard Medical School
MBIB, Room 1037 A
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/432-1930
Fax617/432-0115

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Naik S, Brock S, Akkaladevi N, Tally J, McGinn-Straub W, Zhang N, Gao P, Gogol EP, Pentelute BL, Collier RJ, Fisher MT. Monitoring the Kinetics of the pH-Driven Transition of the Anthrax Toxin Prepore to the Pore by Biolayer Interferometry and Surface Plasmon Resonance. Biochemistry. 2013 Sep 17; 52(37):6335-47.
    View in: PubMed
  2. McCluskey AJ, Collier RJ. Receptor-directed chimeric toxins created by sortase-mediated protein fusion. Mol Cancer Ther. 2013 Oct; 12(10):2273-81.
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  3. Gogol EP, Akkaladevi N, Szerszen L, Mukherjee S, Chollet-Hinton L, Katayama H, Pentelute BL, Collier RJ, Fisher MT. Three dimensional structure of the anthrax toxin translocon-lethal factor complex by cryo-electron microscopy. Protein Sci. 2013 May; 22(5):586-94.
    View in: PubMed
  4. Akkaladevi N, Hinton-Chollet L, Katayama H, Mitchell J, Szerszen L, Mukherjee S, Gogol EP, Pentelute BL, Collier RJ, Fisher MT. Assembly of anthrax toxin pore: Lethal-factor complexes into lipid nanodiscs. Protein Sci. 2013 Apr; 22(4):492-501.
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  5. Slater LH, Hett EC, Mark K, Chumbler NM, Patel D, Lacy DB, Collier RJ, Hung DT. Identification of novel host-targeted compounds that protect from anthrax lethal toxin-induced cell death. ACS Chem Biol. 2013 Apr 19; 8(4):812-22.
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  6. McCluskey AJ, Olive AJ, Starnbach MN, Collier RJ. Targeting HER2-positive cancer cells with receptor-redirected anthrax protective antigen. Mol Oncol. 2013 Jun; 7(3):440-51.
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  7. Mechaly A, McCluskey AJ, Collier RJ. Changing the receptor specificity of anthrax toxin. MBio. 2012; 3(3).
    View in: PubMed
  8. Rodnin MV, Kyrychenko A, Kienker P, Sharma O, Vargas-Uribe M, Collier RJ, Finkelstein A, Ladokhin AS. Replacement of C-terminal histidines uncouples membrane insertion and translocation in diphtheria toxin T-domain. Biophys J. 2011 Nov 16; 101(10):L41-3.
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  9. Fischer A, Holden MA, Pentelute BL, Collier RJ. Ultrasensitive detection of protein translocated through toxin pores in droplet-interface bilayers. Proc Natl Acad Sci U S A. 2011 Oct 4; 108(40):16577-81.
    View in: PubMed
  10. Janowiak BE, Jennings-Antipov LD, Collier RJ. Cys-Cys cross-linking shows contact between the N-terminus of lethal factor and Phe427 of the anthrax toxin pore. Biochemistry. 2011 May 3; 50(17):3512-6.
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  11. Pentelute BL, Sharma O, Collier RJ. Chemical dissection of protein translocation through the anthrax toxin pore. Angew Chem Int Ed Engl. 2011 Mar 1; 50(10):2294-6.
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  12. Jennings-Antipov LD, Song L, Collier RJ. Interactions of anthrax lethal factor with protective antigen defined by site-directed spin labeling. Proc Natl Acad Sci U S A. 2011 Feb 1; 108(5):1868-73.
    View in: PubMed
  13. Dmochewitz L, Lillich M, Kaiser E, Jennings LD, Lang AE, Buchner J, Fischer G, Aktories K, Collier RJ, Barth H. Role of CypA and Hsp90 in membrane translocation mediated by anthrax protective antigen. Cell Microbiol. 2011 Mar; 13(3):359-73.
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  14. Zornetta I, Brandi L, Janowiak B, Dal Molin F, Tonello F, Collier RJ, Montecucco C. Imaging the cell entry of the anthrax oedema and lethal toxins with fluorescent protein chimeras. Cell Microbiol. 2010 Oct; 12(10):1435-45.
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  15. Rodnin MV, Kyrychenko A, Kienker P, Sharma O, Posokhov YO, Collier RJ, Finkelstein A, Ladokhin AS. Conformational switching of the diphtheria toxin T domain. J Mol Biol. 2010 Sep 10; 402(1):1-7.
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  16. Collier RJ. Microbiology. Salmonella's safety catch. Science. 2010 May 21; 328(5981):981-2.
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  17. Sun J, Collier RJ. Disulfide bonds in the ectodomain of anthrax toxin receptor 2 are required for the receptor-bound protective-antigen pore to function. PLoS One. 2010; 5(5):e10553.
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  18. Pentelute BL, Barker AP, Janowiak BE, Kent SB, Collier RJ. A semisynthesis platform for investigating structure-function relationships in the N-terminal domain of the anthrax Lethal Factor. ACS Chem Biol. 2010 Apr 16; 5(4):359-64.
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  19. Katayama H, Wang J, Tama F, Chollet L, Gogol EP, Collier RJ, Fisher MT. Three-dimensional structure of the anthrax toxin pore inserted into lipid nanodiscs and lipid vesicles. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3453-7.
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  20. Janowiak BE, Fischer A, Collier RJ. Effects of introducing a single charged residue into the phenylalanine clamp of multimeric anthrax protective antigen. J Biol Chem. 2010 Mar 12; 285(11):8130-7.
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  21. Vernier G, Wang J, Jennings LD, Sun J, Fischer A, Song L, Collier RJ. Solubilization and characterization of the anthrax toxin pore in detergent micelles. Protein Sci. 2009 Sep; 18(9):1882-95.
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  22. Wang J, Vernier G, Fischer A, Collier RJ. Functions of phenylalanine residues within the beta-barrel stem of the anthrax toxin pore. PLoS One. 2009; 4(7):e6280.
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  23. Collier RJ. Membrane translocation by anthrax toxin. Mol Aspects Med. 2009 Dec; 30(6):413-22.
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  24. Basilio D, Juris SJ, Collier RJ, Finkelstein A. Evidence for a proton-protein symport mechanism in the anthrax toxin channel. J Gen Physiol. 2009 Mar; 133(3):307-14.
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  25. Janowiak BE, Finkelstein A, Collier RJ. An approach to characterizing single-subunit mutations in multimeric prepores and pores of anthrax protective antigen. Protein Sci. 2009 Feb; 18(2):348-58.
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  26. Lang AE, Neumeyer T, Sun J, Collier RJ, Benz R, Aktories K. Amino acid residues involved in membrane insertion and pore formation of Clostridium botulinum C2 toxin. Biochemistry. 2008 Aug 12; 47(32):8406-13.
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  27. Katayama H, Janowiak BE, Brzozowski M, Juryck J, Falke S, Gogol EP, Collier RJ, Fisher MT. GroEL as a molecular scaffold for structural analysis of the anthrax toxin pore. Nat Struct Mol Biol. 2008 Jul; 15(7):754-60.
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  28. Kim C, Wilcox-Adelman S, Sano Y, Tang WJ, Collier RJ, Park JM. Antiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus. Proc Natl Acad Sci U S A. 2008 Apr 22; 105(16):6150-5.
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  29. Sun J, Lang AE, Aktories K, Collier RJ. Phenylalanine-427 of anthrax protective antigen functions in both pore formation and protein translocation. Proc Natl Acad Sci U S A. 2008 Mar 18; 105(11):4346-51.
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  30. Bolcome RE, Sullivan SE, Zeller R, Barker AP, Collier RJ, Chan J. Anthrax lethal toxin induces cell death-independent permeability in zebrafish vasculature. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2439-44.
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  31. Wimalasena DS, Cramer JC, Janowiak BE, Juris SJ, Melnyk RA, Anderson DE, Kirk KL, Collier RJ, Bann JG. Effect of 2-fluorohistidine labeling of the anthrax protective antigen on stability, pore formation, and translocation. Biochemistry. 2007 Dec 25; 46(51):14928-36.
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  32. Rogers MS, Christensen KA, Birsner AE, Short SM, Wigelsworth DJ, Collier RJ, D'Amato RJ. Mutant anthrax toxin B moiety (protective antigen) inhibits angiogenesis and tumor growth. Cancer Res. 2007 Oct 15; 67(20):9980-5.
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  33. Juris SJ, Melnyk RA, Bolcome RE, Chan J, Collier RJ. Cross-linked forms of the isolated N-terminal domain of the lethal factor are potent inhibitors of anthrax toxin. Infect Immun. 2007 Oct; 75(10):5052-8.
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  34. Scobie HM, Marlett JM, Rainey GJ, Lacy DB, Collier RJ, Young JA. Anthrax toxin receptor 2 determinants that dictate the pH threshold of toxin pore formation. PLoS One. 2007; 2(3):e329.
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  35. Young JA, Collier RJ. Anthrax toxin: receptor binding, internalization, pore formation, and translocation. Annu Rev Biochem. 2007; 76:243-65.
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  36. Sun J, Vernier G, Wigelsworth DJ, Collier RJ. Insertion of anthrax protective antigen into liposomal membranes: effects of a receptor. J Biol Chem. 2007 Jan 12; 282(2):1059-65.
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  37. Scobie HM, Wigelsworth DJ, Marlett JM, Thomas D, Rainey GJ, Lacy DB, Manchester M, Collier RJ, Young JA. Anthrax toxin receptor 2-dependent lethal toxin killing in vivo. PLoS Pathog. 2006 Oct; 2(10):e111.
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  38. Rivera J, Nakouzi A, Abboud N, Revskaya E, Goldman D, Collier RJ, Dadachova E, Casadevall A. A monoclonal antibody to Bacillus anthracis protective antigen defines a neutralizing epitope in domain 1. Infect Immun. 2006 Jul; 74(7):4149-56.
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  39. Melnyk RA, Collier RJ. A loop network within the anthrax toxin pore positions the phenylalanine clamp in an active conformation. Proc Natl Acad Sci U S A. 2006 Jun 27; 103(26):9802-7.
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  40. Christensen KA, Krantz BA, Collier RJ. Assembly and disassembly kinetics of anthrax toxin complexes. Biochemistry. 2006 Feb 21; 45(7):2380-6.
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  41. Krantz BA, Finkelstein A, Collier RJ. Protein translocation through the anthrax toxin transmembrane pore is driven by a proton gradient. J Mol Biol. 2006 Feb 3; 355(5):968-79.
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  42. Melnyk RA, Hewitt KM, Lacy DB, Lin HC, Gessner CR, Li S, Woods VL, Collier RJ. Structural determinants for the binding of anthrax lethal factor to oligomeric protective antigen. J Biol Chem. 2006 Jan 20; 281(3):1630-5.
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  43. Lacy DB, Lin HC, Melnyk RA, Schueler-Furman O, Reither L, Cunningham K, Baker D, Collier RJ. A model of anthrax toxin lethal factor bound to protective antigen. Proc Natl Acad Sci U S A. 2005 Nov 8; 102(45):16409-14.
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  44. Wolfe JT, Krantz BA, Rainey GJ, Young JA, Collier RJ. Whole-cell voltage clamp measurements of anthrax toxin pore current. J Biol Chem. 2005 Nov 25; 280(47):39417-22.
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  45. Rainey GJ, Wigelsworth DJ, Ryan PL, Scobie HM, Collier RJ, Young JA. Receptor-specific requirements for anthrax toxin delivery into cells. Proc Natl Acad Sci U S A. 2005 Sep 13; 102(37):13278-83.
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  46. Scobie HM, Thomas D, Marlett JM, Destito G, Wigelsworth DJ, Collier RJ, Young JA, Manchester M. A soluble receptor decoy protects rats against anthrax lethal toxin challenge. J Infect Dis. 2005 Sep 15; 192(6):1047-51.
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  47. Krantz BA, Melnyk RA, Zhang S, Juris SJ, Lacy DB, Wu Z, Finkelstein A, Collier RJ. A phenylalanine clamp catalyzes protein translocation through the anthrax toxin pore. Science. 2005 Jul 29; 309(5735):777-81.
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  48. Qa'dan M, Christensen KA, Zhang L, Roberts TM, Collier RJ. Membrane insertion by anthrax protective antigen in cultured cells. Mol Cell Biol. 2005 Jul; 25(13):5492-8.
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  49. Aulinger BA, Roehrl MH, Mekalanos JJ, Collier RJ, Wang JY. Combining anthrax vaccine and therapy: a dominant-negative inhibitor of anthrax toxin is also a potent and safe immunogen for vaccines. Infect Immun. 2005 Jun; 73(6):3408-14.
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  50. Altman S, Bassler BL, Beckwith J, Belfort M, Berg HC, Bloom B, Brenchley JE, Campbell A, Collier RJ, Connell N, Cozzarelli NR, Craig NL, Darst S, Ebright RH, Elledge SJ, Falkow S, Galan JE, Gottesman M, Gourse R, Grindley ND, Gross CA, Grossman A, Hochschild A, Howe M, Hurwitz J, Isberg RR, Kaplan S, Kornberg A, Kustu SG, Landick RC, Landy A, Levy SB, Losick R, Long SR, Maloy SR, Mekalanos JJ, Neidhardt FC, Pace NR, Ptashne M, Roberts JW, Roth JR, Rothman-Denes LB, Salyers A, Schaechter M, Shapiro L, Silhavy TJ, Simon MI, Walker G, Yanofsky C, Zinder N. An open letter to Elias Zerhouni. Science. 2005 Mar 4; 307(5714):1409-10.
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  51. Christensen KA, Krantz BA, Melnyk RA, Collier RJ. Interaction of the 20 kDa and 63 kDa fragments of anthrax protective antigen: kinetics and thermodynamics. Biochemistry. 2005 Jan 25; 44(3):1047-53.
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  52. Krantz BA, Trivedi AD, Cunningham K, Christensen KA, Collier RJ. Acid-induced unfolding of the amino-terminal domains of the lethal and edema factors of anthrax toxin. J Mol Biol. 2004 Nov 26; 344(3):739-56.
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  53. Zhang S, Finkelstein A, Collier RJ. Evidence that translocation of anthrax toxin's lethal factor is initiated by entry of its N terminus into the protective antigen channel. Proc Natl Acad Sci U S A. 2004 Nov 30; 101(48):16756-61.
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  54. Oh KJ, Barbuto S, Meyer N, Kim RS, Collier RJ, Korsmeyer SJ. Conformational changes in BID, a pro-apoptotic BCL-2 family member, upon membrane binding. A site-directed spin labeling study. J Biol Chem. 2005 Jan 7; 280(1):753-67.
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  55. Zhang S, Udho E, Wu Z, Collier RJ, Finkelstein A. Protein translocation through anthrax toxin channels formed in planar lipid bilayers. Biophys J. 2004 Dec; 87(6):3842-9.
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  56. Pimental RA, Christensen KA, Krantz BA, Collier RJ. Anthrax toxin complexes: heptameric protective antigen can bind lethal factor and edema factor simultaneously. Biochem Biophys Res Commun. 2004 Sep 10; 322(1):258-62.
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  57. Lacy DB, Wigelsworth DJ, Melnyk RA, Harrison SC, Collier RJ. Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation. Proc Natl Acad Sci U S A. 2004 Sep 7; 101(36):13147-51.
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  58. Boll W, Ehrlich M, Collier RJ, Kirchhausen T. Effects of dynamin inactivation on pathways of anthrax toxin uptake. Eur J Cell Biol. 2004 Jul; 83(6):281-8.
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  59. Ladokhin AS, Legmann R, Collier RJ, White SH. Reversible refolding of the diphtheria toxin T-domain on lipid membranes. Biochemistry. 2004 Jun 15; 43(23):7451-8.
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  60. Zhang S, Cunningham K, Collier RJ. Anthrax protective antigen: efficiency of translocation is independent of the number of ligands bound to the prepore. Biochemistry. 2004 May 25; 43(20):6339-43.
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  61. Lacy DB, Wigelsworth DJ, Scobie HM, Young JA, Collier RJ. Crystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor. Proc Natl Acad Sci U S A. 2004 Apr 27; 101(17):6367-72.
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  62. Wigelsworth DJ, Krantz BA, Christensen KA, Lacy DB, Juris SJ, Collier RJ. Binding stoichiometry and kinetics of the interaction of a human anthrax toxin receptor, CMG2, with protective antigen. J Biol Chem. 2004 May 28; 279(22):23349-56.
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  63. Mourez M, Collier RJ. Use of phage display and polyvalency to design inhibitors of protein-protein interactions. Methods Mol Biol. 2004; 261:213-28.
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  64. Turk BE, Wong TY, Schwarzenbacher R, Jarrell ET, Leppla SH, Collier RJ, Liddington RC, Cantley LC. The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor. Nat Struct Mol Biol. 2004 Jan; 11(1):60-6.
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  65. Mourez M, Yan M, Lacy DB, Dillon L, Bentsen L, Marpoe A, Maurin C, Hotze E, Wigelsworth D, Pimental RA, Ballard JD, Collier RJ, Tweten RK. Mapping dominant-negative mutations of anthrax protective antigen by scanning mutagenesis. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):13803-8.
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  66. Rhie GE, Roehrl MH, Mourez M, Collier RJ, Mekalanos JJ, Wang JY. A dually active anthrax vaccine that confers protection against both bacilli and toxins. Proc Natl Acad Sci U S A. 2003 Sep 16; 100(19):10925-30.
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  67. Croney JC, Cunningham KM, Collier RJ, Jameson DM. Fluorescence resonance energy transfer studies on anthrax lethal toxin. FEBS Lett. 2003 Aug 28; 550(1-3):175-8.
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  68. Starnbach MN, Collier RJ. Anthrax delivers a lethal blow to host immunity. Nat Med. 2003 Aug; 9(8):996-7.
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  69. Gao-Sheridan S, Zhang S, Collier RJ. Exchange characteristics of calcium ions bound to anthrax protective antigen. Biochem Biophys Res Commun. 2003 Jan 3; 300(1):61-4.
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  70. Collier RJ, Young JA. Anthrax toxin. Annu Rev Cell Dev Biol. 2003; 19:45-70.
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  71. Yan M, Collier RJ. Characterization of dominant-negative forms of anthrax protective antigen. Mol Med. 2003 Jan-Feb; 9(1-2):46-51.
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  72. Mourez M, Lacy DB, Cunningham K, Legmann R, Sellman BR, Mogridge J, Collier RJ. 2001: a year of major advances in anthrax toxin research. Trends Microbiol. 2002 Jun; 10(6):287-93.
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  73. Cunningham K, Lacy DB, Mogridge J, Collier RJ. Mapping the lethal factor and edema factor binding sites on oligomeric anthrax protective antigen. Proc Natl Acad Sci U S A. 2002 May 14; 99(10):7049-53.
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  74. Mogridge J, Cunningham K, Lacy DB, Mourez M, Collier RJ. The lethal and edema factors of anthrax toxin bind only to oligomeric forms of the protective antigen. Proc Natl Acad Sci U S A. 2002 May 14; 99(10):7045-8.
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  75. Nassi S, Collier RJ, Finkelstein A. PA63 channel of anthrax toxin: an extended beta-barrel. Biochemistry. 2002 Feb 5; 41(5):1445-50.
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  76. Mogridge J, Cunningham K, Collier RJ. Stoichiometry of anthrax toxin complexes. Biochemistry. 2002 Jan 22; 41(3):1079-82.
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  77. Lacy DB, Collier RJ. Structure and function of anthrax toxin. Curr Top Microbiol Immunol. 2002; 271:61-85.
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  78. Wedekind JE, Trame CB, Dorywalska M, Koehl P, Raschke TM, McKee M, FitzGerald D, Collier RJ, McKay DB. Refined crystallographic structure of Pseudomonas aeruginosa exotoxin A and its implications for the molecular mechanism of toxicity. J Mol Biol. 2001 Dec 7; 314(4):823-37.
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  79. Lacy DB, Mourez M, Fouassier A, Collier RJ. Mapping the anthrax protective antigen binding site on the lethal and edema factors. J Biol Chem. 2002 Jan 25; 277(4):3006-10.
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  80. Paoletti LC, Peterson DL, Legmann R, Collier RJ. Preclinical evaluation of group B streptococcal polysaccharide conjugate vaccines prepared with a modified diphtheria toxin and a recombinant duck hepatitis B core antigen. Vaccine. 2001 Nov 12; 20(3-4):370-6.
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  81. Pannifer AD, Wong TY, Schwarzenbacher R, Renatus M, Petosa C, Bienkowska J, Lacy DB, Collier RJ, Park S, Leppla SH, Hanna P, Liddington RC. Crystal structure of the anthrax lethal factor. Nature. 2001 Nov 8; 414(6860):229-33.
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  82. Bradley KA, Mogridge J, Mourez M, Collier RJ, Young JA. Identification of the cellular receptor for anthrax toxin. Nature. 2001 Nov 8; 414(6860):225-9.
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  83. Collier RJ. Understanding the mode of action of diphtheria toxin: a perspective on progress during the 20th century. Toxicon. 2001 Nov; 39(11):1793-803.
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  84. Mourez M, Kane RS, Mogridge J, Metallo S, Deschatelets P, Sellman BR, Whitesides GM, Collier RJ. Designing a polyvalent inhibitor of anthrax toxin. Nat Biotechnol. 2001 Oct; 19(10):958-61.
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  85. Liu XH, Collier RJ, Youle RJ. Inhibition of axotomy-induced neuronal apoptosis by extracellular delivery of a Bcl-XL fusion protein. J Biol Chem. 2001 Dec 7; 276(49):46326-32.
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  86. Van Dover CL, Humphris SE, Fornari D, Cavanaugh CM, Collier R, Goffredi SK, Hashimoto J, Lilley MD, Reysenbach AL, Shank TM, Von Damm KL, Banta A, Gallant RM, Gotz D, Green D, Hall J, Harmer TL, Hurtado LA, Johnson P, McKiness ZP, Meredith C, Olson E, Pan IL, Turnipseed M, Won Y, Young CR, Vrijenhoek RC. Biogeography and ecological setting of Indian Ocean hydrothermal vents. Science. 2001 Oct 26; 294(5543):818-23.
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  87. Sellman BR, Mourez M, Collier RJ. Dominant-negative mutants of a toxin subunit: an approach to therapy of anthrax. Science. 2001 Apr 27; 292(5517):695-7.
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  88. Crawford MJ, Krishnamoorthy RR, Rudick VL, Collier RJ, Kapin M, Aggarwal BB, Al-Ubaidi MR, Agarwal N. Bcl-2 overexpression protects photooxidative stress-induced apoptosis of photoreceptor cells via NF-kappaB preservation. Biochem Biophys Res Commun. 2001 Mar; 281(5):1304-12.
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  89. Mogridge J, Mourez M, Collier RJ. Involvement of domain 3 in oligomerization by the protective antigen moiety of anthrax toxin. J Bacteriol. 2001 Mar; 183(6):2111-6.
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  90. Sellman BR, Nassi S, Collier RJ. Point mutations in anthrax protective antigen that block translocation. J Biol Chem. 2001 Mar 16; 276(11):8371-6.
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  91. Finkelstein A, Oh KJ, Senzel L, Gordon M, Blaustein RO, Collier RJ. The diphtheria toxin channel-forming T-domain translocates its own NH2-terminal region and the catalytic domain across planar phospholipid bilayers. Int J Med Microbiol. 2000 Oct; 290(4-5):435-40.
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  92. Elliott JL, Mogridge J, Collier RJ. A quantitative study of the interactions of Bacillus anthracis edema factor and lethal factor with activated protective antigen. Biochemistry. 2000 Jun 6; 39(22):6706-13.
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  93. Beauregard KE, Collier RJ, Swanson JA. Proteolytic activation of receptor-bound anthrax protective antigen on macrophages promotes its internalization. Cell Microbiol. 2000 Jun; 2(3):251-8.
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  94. Senzel L, Gordon M, Blaustein RO, Oh KJ, Collier RJ, Finkelstein A. Topography of diphtheria Toxin's T domain in the open channel state. J Gen Physiol. 2000 Apr; 115(4):421-34.
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  95. Zarozinski CC, Collier RJ, Starnbach MN. Use of anthrax toxin fusions to stimulate immune responses. Methods Enzymol. 2000; 326:542-51.
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  96. Oh KJ, Altenbach C, Collier RJ, Hubbell WL. Site-directed spin labeling of proteins. Applications to diphtheria toxin. Methods Mol Biol. 2000; 145:147-69.
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  97. Lodaya R, Blanke SR, Collier RJ, Slama JT. Photoaffinity labeling of diphtheria toxin fragment A with 8-azidoadenosyl nicotinamide adenine dinucleotide. Biochemistry. 1999 Oct 19; 38(42):13877-86.
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  98. Miller CJ, Elliott JL, Collier RJ. Anthrax protective antigen: prepore-to-pore conversion. Biochemistry. 1999 Aug 10; 38(32):10432-41.
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  99. Oh KJ, Zhan H, Cui C, Altenbach C, Hubbell WL, Collier RJ. Conformation of the diphtheria toxin T domain in membranes: a site-directed spin-labeling study of the TH8 helix and TL5 loop. Biochemistry. 1999 Aug 10; 38(32):10336-43.
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  100. Collier RJ. Mechanism of membrane translocation by anthrax toxin: insertion and pore formation by protective antigen J Appl Microbiol. 1999 Aug; 87(2):283.
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  101. Liddington R, Pannifer A, Hanna P, Leppla S, Collier RJ. Crystallographic studies of the anthrax lethal toxin J Appl Microbiol. 1999 Aug; 87(2):282.
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  102. Oh KJ, Senzel L, Collier RJ, Finkelstein A. Translocation of the catalytic domain of diphtheria toxin across planar phospholipid bilayers by its own T domain. Proc Natl Acad Sci U S A. 1999 Jul 20; 96(15):8467-70.
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  103. Doling AM, Ballard JD, Shen H, Krishna KM, Ahmed R, Collier RJ, Starnbach MN. Cytotoxic T-lymphocyte epitopes fused to anthrax toxin induce protective antiviral immunity. Infect Immun. 1999 Jul; 67(7):3290-6.
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  104. Beauregard KE, Wimer-Mackin S, Collier RJ, Lencer WI. Anthrax toxin entry into polarized epithelial cells. Infect Immun. 1999 Jun; 67(6):3026-30.
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  105. Ren J, Kachel K, Kim H, Malenbaum SE, Collier RJ, London E. Interaction of diphtheria toxin T domain with molten globule-like proteins and its implications for translocation. Science. 1999 May 7; 284(5416):955-7.
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  106. Ren J, Sharpe JC, Collier RJ, London E. Membrane translocation of charged residues at the tips of hydrophobic helices in the T domain of diphtheria toxin. Biochemistry. 1999 Jan 19; 38(3):976-84.
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  107. Zhan H, Elliott JL, Shen WH, Huynh PD, Finkelstein A, Collier RJ. Effects of mutations in proline 345 on insertion of diphtheria toxin into model membranes. J Membr Biol. 1999 Jan 15; 167(2):173-81.
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  108. Malenbaum SE, Collier RJ, London E. Membrane topography of the T domain of diphtheria toxin probed with single tryptophan mutants. Biochemistry. 1998 Dec 22; 37(51):17915-22.
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  109. Wesche J, Elliott JL, Falnes PO, Olsnes S, Collier RJ. Characterization of membrane translocation by anthrax protective antigen. Biochemistry. 1998 Nov 10; 37(45):15737-46.
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  110. Ballard JD, Collier RJ, Starnbach MN. Anthrax toxin as a molecular tool for stimulation of cytotoxic T lymphocytes: disulfide-linked epitopes, multiple injections, and role of CD4(+) cells. Infect Immun. 1998 Oct; 66(10):4696-9.
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  115. Beauregard KE, Lee KD, Collier RJ, Swanson JA. pH-dependent perforation of macrophage phagosomes by listeriolysin O from Listeria monocytogenes. J Exp Med. 1997 Oct 6; 186(7):1159-63.
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  116. Wang Y, Malenbaum SE, Kachel K, Zhan H, Collier RJ, London E. Identification of shallow and deep membrane-penetrating forms of diphtheria toxin T domain that are regulated by protein concentration and bilayer width. J Biol Chem. 1997 Oct 3; 272(40):25091-8.
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  117. Huynh PD, Cui C, Zhan H, Oh KJ, Collier RJ, Finkelstein A. Probing the structure of the diphtheria toxin channel. Reactivity in planar lipid bilayer membranes of cysteine-substituted mutant channels with methanethiosulfonate derivatives. J Gen Physiol. 1997 Sep; 110(3):229-42.
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  118. Gupta RK, Collier RJ, Rappuoli R, Siber GR. Differences in the immunogenicity of native and formalinized cross reacting material (CRM197) of diphtheria toxin in mice and guinea pigs and their implications on the development and control of diphtheria vaccine based on CRMs. Vaccine. 1997 Aug-Sep; 15(12-13):1341-3.
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  120. Fu H, Blanke SR, Mattheakis LC, Collier RJ. Selection of diphtheria toxin active-site mutants in yeast. Rediscovery of glutamic acid-148 as a key residue. Adv Exp Med Biol. 1997; 419:45-52.
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  121. Chen SY, Yang AG, Chen JD, Kute T, King CR, Collier RJ, Cong YP, Yao CP, Huang XF. Potent antitumour activity of a new class of tumour-specific killer cells. Nature. 1997; (385):78-80.
  122. Ballard JD, Collier RJ, Starnbach MN. Anthrax toxin-mediated delivery of a cytotoxic T-cell epitope in vivo. Proc Natl Acad Sci U S A. 1996 Oct 29; 93(22):12531-4.
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  123. Heap D, Collier RJ, Boyd CK, Lucy MC. Expression of alternate growth hormone receptor messenger RNA in ovary and uterus of cattle. Domest Anim Endocrinol. 1996 Sep; 13(5):421-30.
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  125. Blanke SR, Milne JC, Benson EL, Collier RJ. Fused polycationic peptide mediates delivery of diphtheria toxin A chain to the cytosol in the presence of anthrax protective antigen. Proc Natl Acad Sci U S A. 1996 Aug 6; 93(16):8437-42.
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  126. Kaul P, Silverman J, Shen WH, Blanke SR, Huynh PD, Finkelstein A, Collier RJ. Roles of Glu 349 and Asp 352 in membrane insertion and translocation by diphtheria toxin. Protein Sci. 1996 Apr; 5(4):687-92.
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  127. Byatt JC, Collier RJ. Specific endometrial binding sites for bovine placental lactogen are antigenically similar to the growth hormone receptor. Proc Soc Exp Biol Med. 1995 Oct; 210(1):20-4.
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  128. Zhao J, Milne JC, Collier RJ. Effect of anthrax toxin's lethal factor on ion channels formed by the protective antigen. J Biol Chem. 1995 Aug 4; 270(31):18626-30.
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  129. Liu D, Bienkowska J, Petosa C, Collier RJ, Fu H, Liddington R. Crystal structure of the zeta isoform of the 14-3-3 protein. Nature. 1995 Jul 13; 376(6536):191-4.
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  130. Heap D, Lucy MC, Collier RJ, Boyd CK, Warren WC. Rapid communication: nucleotide sequence of the promoter and first exon of the somatotropin receptor gene in cattle. J Anim Sci. 1995 May; 73(5):1529.
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  131. Zhan H, Oh KJ, Shin YK, Hubbell WL, Collier RJ. Interaction of the isolated transmembrane domain of diphtheria toxin with membranes. Biochemistry. 1995 Apr 11; 34(14):4856-63.
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  132. Marsischky GT, Wilson BA, Collier RJ. Role of glutamic acid 988 of human poly-ADP-ribose polymerase in polymer formation. Evidence for active site similarities to the ADP-ribosylating toxins. J Biol Chem. 1995 Feb 17; 270(7):3247-54.
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  133. Milne JC, Blanke SR, Hanna PC, Collier RJ. Protective antigen-binding domain of anthrax lethal factor mediates translocation of a heterologous protein fused to its amino- or carboxy-terminus. Mol Microbiol. 1995 Feb; 15(4):661-6.
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  134. Mahan MJ, Tobias JW, Slauch JM, Hanna PC, Collier RJ, Mekalanos JJ. Antibiotic-based selection for bacterial genes that are specifically induced during infection of a host. Proc Natl Acad Sci U S A. 1995 Jan 31; 92(3):669-73.
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  135. Weiss MS, Blanke SR, Collier RJ, Eisenberg D. Structure of the isolated catalytic domain of diphtheria toxin. Biochemistry. 1995 Jan 24; 34(3):773-81.
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  136. Lucy MC, Thatcher WW, Collier RJ, Simmen FA, Ko Y, Savio JD, Badinga L. Effects of somatotropin on the conceptus, uterus, and ovary during maternal recognition of pregnancy in cattle. Domest Anim Endocrinol. 1995 Jan; 12(1):73-82.
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  137. Blanke SR, Huang K, Collier RJ. Active-site mutations of diphtheria toxin: role of tyrosine-65 in NAD binding and ADP-ribosylation. Biochemistry. 1994 Dec 27; 33(51):15494-500.
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  138. Shen WH, Choe S, Eisenberg D, Collier RJ. Participation of lysine 516 and phenylalanine 530 of diphtheria toxin in receptor recognition. J Biol Chem. 1994 Nov 18; 269(46):29077-84.
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  139. Hanna PC, Kruskal BA, Ezekowitz RA, Bloom BR, Collier RJ. Role of macrophage oxidative burst in the action of anthrax lethal toxin. Mol Med. 1994 Nov; 1(1):7-18.
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  140. Reuther GW, Fu H, Cripe LD, Collier RJ, Pendergast AM. Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family. Science. 1994 Oct 7; 266(5182):129-33.
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  141. Fu H, Xia K, Pallas DC, Cui C, Conroy K, Narsimhan RP, Mamon H, Collier RJ, Roberts TM. Interaction of the protein kinase Raf-1 with 14-3-3 proteins. Science. 1994 Oct 7; 266(5182):126-9.
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  142. Zhan H, Choe S, Huynh PD, Finkelstein A, Eisenberg D, Collier RJ. Dynamic transitions of the transmembrane domain of diphtheria toxin: disulfide trapping and fluorescence proximity studies. Biochemistry. 1994 Sep 20; 33(37):11254-63.
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  143. Collier RJ, Clemmons DR, Donovan SM. Safety of milk from cows treated with bovine somatotrophin. Lancet. 1994 Sep 17; 344(8925):816.
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  145. Silverman JA, Mindell JA, Finkelstein A, Shen WH, Collier RJ. Mutational analysis of the helical hairpin region of diphtheria toxin transmembrane domain. J Biol Chem. 1994 Sep 9; 269(36):22524-32.
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  146. Milne JC, Furlong D, Hanna PC, Wall JS, Collier RJ. Anthrax protective antigen forms oligomers during intoxication of mammalian cells. J Biol Chem. 1994 Aug 12; 269(32):20607-12.
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  147. Pallas DC, Fu H, Haehnel LC, Weller W, Collier RJ, Roberts TM. Association of polyomavirus middle tumor antigen with 14-3-3 proteins. Science. 1994 Jul 22; 265(5171):535-7.
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  148. Mindell JA, Zhan H, Huynh PD, Collier RJ, Finkelstein A. Reaction of diphtheria toxin channels with sulfhydryl-specific reagents: observation of chemical reactions at the single molecule level. Proc Natl Acad Sci U S A. 1994 Jun 7; 91(12):5272-6.
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  149. Blanke SR, Huang K, Wilson BA, Papini E, Covacci A, Collier RJ. Active-site mutations of the diphtheria toxin catalytic domain: role of histidine-21 in nicotinamide adenine dinucleotide binding and ADP-ribosylation of elongation factor 2. Biochemistry. 1994 May 3; 33(17):5155-61.
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  151. Byatt JC, Eppard PJ, Veenhuizen JJ, Curran TL, Curran DF, McGrath MF, Collier RJ. Stimulation of mammogenesis and lactogenesis by recombinant bovine placental lactogen in steroid-primed dairy heifers. J Endocrinol. 1994 Jan; 140(1):33-43.
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  152. Mindell JA, Silverman JA, Collier RJ, Finkelstein A. Structure-function relationships in diphtheria toxin channels: III. Residues which affect the cis pH dependence of channel conductance. J Membr Biol. 1994 Jan; 137(1):45-57.
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  153. Carroll SF, Collier RJ. Photoaffinity labeling of active site residues in ADP-ribosylating toxins. Methods Enzymol. 1994; 235:631-9.
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  156. Hanna PC, Acosta D, Collier RJ. On the role of macrophages in anthrax. Proc Natl Acad Sci U S A. 1993 Nov 1; 90(21):10198-201.
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  157. Milne JC, Collier RJ. pH-dependent permeabilization of the plasma membrane of mammalian cells by anthrax protective antigen. Mol Microbiol. 1993 Nov; 10(3):647-53.
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  158. Lucy MC, Hauser SD, Eppard PJ, Krivi GG, Clark JH, Bauman DE, Collier RJ. Variants of somatotropin in cattle: gene frequencies in major dairy breeds and associated milk production. Domest Anim Endocrinol. 1993 Oct; 10(4):325-33.
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  159. Mattheakis LC, Sor F, Collier RJ. Diphthamide synthesis in Saccharomyces cerevisiae: structure of the DPH2 gene. Gene. 1993 Sep 30; 132(1):149-54.
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  160. Kochi SK, Collier RJ. DNA fragmentation and cytolysis in U937 cells treated with diphtheria toxin or other inhibitors of protein synthesis. Exp Cell Res. 1993 Sep; 208(1):296-302.
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  161. Byatt JC, Staten NR, Salsgiver WJ, Kostelc JG, Collier RJ. Stimulation of food intake and weight gain in mature female rats by bovine prolactin and bovine growth hormone. Am J Physiol. 1993 Jun; 264(6 Pt 1):E986-92.
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  162. Lucy MC, Collier RJ, Kitchell ML, Dibner JJ, Hauser SD, Krivi GG. Immunohistochemical and nucleic acid analysis of somatotropin receptor populations in the bovine ovary. Biol Reprod. 1993 Jun; 48(6):1219-27.
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  163. Cabiaux V, Mindell J, Collier RJ. Membrane translocation and channel-forming activities of diphtheria toxin are blocked by replacing isoleucine 364 with lysine. Infect Immun. 1993 May; 61(5):2200-2.
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  164. Fu H, Coburn J, Collier RJ. The eukaryotic host factor that activates exoenzyme S of Pseudomonas aeruginosa is a member of the 14-3-3 protein family. Proc Natl Acad Sci U S A. 1993 Mar 15; 90(6):2320-4.
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  165. Hanna PC, Kochi S, Collier RJ. Biochemical and physiological changes induced by anthrax lethal toxin in J774 macrophage-like cells. Mol Biol Cell. 1992 Nov; 3(11):1269-77.
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  166. Mattheakis LC, Shen WH, Collier RJ. DPH5, a methyltransferase gene required for diphthamide biosynthesis in Saccharomyces cerevisiae. Mol Cell Biol. 1992 Sep; 12(9):4026-37.
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  167. Byatt JC, Warren WC, Eppard PJ, Staten NR, Krivi GG, Collier RJ. Ruminant placental lactogens: structure and biology. J Anim Sci. 1992 Sep; 70(9):2911-23.
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  168. O'Keefe DO, Cabiaux V, Choe S, Eisenberg D, Collier RJ. pH-dependent insertion of proteins into membranes: B-chain mutation of diphtheria toxin that inhibits membrane translocation, Glu-349----Lys. Proc Natl Acad Sci U S A. 1992 Jul 1; 89(13):6202-6.
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  169. Killeen KP, Escuyer V, Mekalanos JJ, Collier RJ. Reversion of recombinant toxoids: mutations in diphtheria toxin that partially compensate for active-site deletions. Proc Natl Acad Sci U S A. 1992 Jul 1; 89(13):6207-9.
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  172. Deresiewicz RL, Calderwood SB, Robertus JD, Collier RJ. Mutations affecting the activity of the Shiga-like toxin I A-chain. Biochemistry. 1992 Mar 31; 31(12):3272-80.
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  173. Killeen KP, Collier RJ. Conformational integrity of a recombinant toxoid of Pseudomonas aeruginosa exotoxin A containing a deletion of glutamic acid-553. Biochim Biophys Acta. 1992 Feb 14; 1138(2):162-6.
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  175. Escuyer V, Collier RJ. Anthrax protective antigen interacts with a specific receptor on the surface of CHO-K1 cells. Infect Immun. 1991 Oct; 59(10):3381-6.
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  176. McGrath MF, Collier RJ, Clemmons DR, Busby WH, Sweeny CA, Krivi GG. The direct in vitro effect of insulin-like growth factors (IGFs) on normal bovine mammary cell proliferation and production of IGF binding proteins. Endocrinology. 1991 Aug; 129(2):671-8.
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  177. Byatt JC, Staten NR, Schmuke JJ, Buonomo FC, Galosy SS, Curran DF, Krivi GG, Collier RJ. Stimulation of body weight gain of the mature female rat by bovine GH and bovine placental lactogen. J Endocrinol. 1991 Jul; 130(1):11-9.
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  178. Koehler TM, Collier RJ. Anthrax toxin protective antigen: low-pH-induced hydrophobicity and channel formation in liposomes. Mol Microbiol. 1991 Jun; 5(6):1501-6.
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  180. Byatt JC, Schmuke JJ, Comens PG, Johnson DA, Collier RJ. The effect of bovine lactoferrin on muscle growth in vivo and in vitro. Biochem Biophys Res Commun. 1990 Dec 14; 173(2):548-53.
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  183. Hauser SD, McGrath MF, Collier RJ, Krivi GG. Cloning and in vivo expression of bovine growth hormone receptor mRNA. Mol Cell Endocrinol. 1990 Sep 10; 72(3):187-200.
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  184. Byatt JC, Welply JK, Leimgruber RM, Collier RJ. Characterization of glycosylated bovine placental lactogen and the effect of enzymatic deglycosylation on receptor binding and biological activity. Endocrinology. 1990 Sep; 127(3):1041-9.
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  185. Douglas CM, Collier RJ. Pseudomonas aeruginosa exotoxin A: alterations of biological and biochemical properties resulting from mutation of glutamic acid 553 to aspartic acid. Biochemistry. 1990 May 29; 29(21):5043-9.
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  186. Cabiaux V, Phalipon A, Kaczorek M, Collier RJ, Ruysschaert JM. Structure and interaction with model membranes of a CNBR peptide of diphtheria toxin B fragment. J Physiol (Paris). 1990; 84(4):273-7.
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  187. Barbieri JT, Mende-Mueller LM, Rappuoli R, Collier RJ. Photolabeling of Glu-129 of the S-1 subunit of pertussis toxin with NAD. Infect Immun. 1989 Nov; 57(11):3549-54.
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  188. Olsnes S, Stenmark H, McGill S, Hovig E, Collier RJ, Sandvig K. Formation of active diphtheria toxin in vitro based on ligated fragments of cloned mutant genes. J Biol Chem. 1989 Aug 5; 264(22):12747-51.
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  189. Madshus IH, Collier RJ. Effects of eliminating a disulfide bridge within domain II of Pseudomonas aeruginosa exotoxin A. Infect Immun. 1989 Jul; 57(7):1873-8.
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  192. Collier RJ, Zigman S. Comparison of retinal photochemical lesions after exposure to near-UV or short-wavelength visible radiation. Prog Clin Biol Res. 1989; 314:569-75.
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  193. O'Keefe D, Collier RJ. Cloned diphtheria toxin within the periplasm of Escherichia coli causes lethal membrane damage at low pH. Proc Natl Acad Sci U S A. 1989 Jan; 86(1):343-6.
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  194. Lukac M, Pier GB, Collier RJ. Toxoid of Pseudomonas aeruginosa exotoxin A generated by deletion of an active-site residue. Infect Immun. 1988 Dec; 56(12):3095-8.
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  195. Lukac M, Collier RJ. Pseudomonas aeruginosa exotoxin A: effects of mutating tyrosine-470 and tyrosine-481 to phenylalanine. Biochemistry. 1988 Oct 4; 27(20):7629-32.
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  196. Lukac M, Collier RJ. Restoration of enzymic activity and cytotoxicity of mutant, E553C, Pseudomonas aeruginosa exotoxin A by reaction with iodoacetic acid. J Biol Chem. 1988 May 5; 263(13):6146-9.
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  197. Hovde CJ, Calderwood SB, Mekalanos JJ, Collier RJ. Evidence that glutamic acid 167 is an active-site residue of Shiga-like toxin I. Proc Natl Acad Sci U S A. 1988 Apr; 85(8):2568-72.
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  198. Carroll SF, Collier RJ. Amino acid sequence homology between the enzymic domains of diphtheria toxin and Pseudomonas aeruginosa exotoxin A. Mol Microbiol. 1988 Mar; 2(2):293-6.
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  203. Douglas CM, Guidi-Rontani C, Collier RJ. Exotoxin A of Pseudomonas aeruginosa: active, cloned toxin is secreted into the periplasmic space of Escherichia coli. J Bacteriol. 1987 Nov; 169(11):4962-6.
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  204. Byatt JC, Wallace CR, Bremel RD, Collier RJ, Bolt DJ. The concentration of bovine placental lactogen and the incidence of different forms in fetal cotyledons and in fetal serum. Domest Anim Endocrinol. 1987 Oct; 4(4):231-41.
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  205. Badinga L, Collier RJ, Thatcher WW, Quintana SJ, Bazer FW. Covalent coupling of bovine growth hormone to its receptor in bovine liver membranes. Mol Cell Endocrinol. 1987 Jul; 52(1-2):85-9.
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  206. Guidi-Rontani C, Collier RJ. Exotoxin A of Pseudomonas aeruginosa: evidence that domain I functions in receptor binding. Mol Microbiol. 1987 Jul; 1(1):67-72.
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  208. Carroll SF, Collier RJ. Active site of Pseudomonas aeruginosa exotoxin A. Glutamic acid 553 is photolabeled by NAD and shows functional homology with glutamic acid 148 of diphtheria toxin. J Biol Chem. 1987 Jun 25; 262(18):8707-11.
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  210. Barbieri JT, Collins CM, Collier RJ. Diphtheria toxin can simultaneously bind to its receptor and adenylyl-(3',5')-uridine 3'-monophosphate. Biochemistry. 1986 Oct 21; 25(21):6608-11.
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  213. Carroll SF, McCloskey JA, Crain PF, Oppenheimer NJ, Marschner TM, Collier RJ. Photoaffinity labeling of diphtheria toxin fragment A with NAD: structure of the photoproduct at position 148. Proc Natl Acad Sci U S A. 1985 Nov; 82(21):7237-41.
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  218. Haro LS, Collier RJ, Talamantes FJ. Homologous somatotropin radioreceptor assay utilizing recombinant bovine growth hormone. Mol Cell Endocrinol. 1984 Dec; 38(2-3):109-16.
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  223. Greenfield L, Bjorn MJ, Horn G, Fong D, Buck GA, Collier RJ, Kaplan DA. Nucleotide sequence of the structural gene for diphtheria toxin carried by corynebacteriophage beta. Proc Natl Acad Sci U S A. 1983 Nov; 80(22):6853-7.
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  224. Tweten RK, Collier RJ. Molecular cloning and expression of gene fragments from corynebacteriophage beta encoding enzymatically active peptides of diphtheria toxin. J Bacteriol. 1983 Nov; 156(2):680-5.
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  225. Kaplan DA, Greenfield L, Collier RJ. Chromogenic method to screen very large populations of bacteriophage plaques for the presence of specific antigen. Methods Enzymol. 1983; 100:342-68.
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  226. Collier RJ, McKay DB. Crystallization of exotoxin A from pseudomonas aeruginosa. J Mol Biol. 1982 May 15; 157(2):413-5.
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  229. Gilliland DG, Collier RJ. Characterization of hybrid molecules containing fragment A from diphtheria toxin linked to concanavalin A or the binding subunit of ricin toxin. J Biol Chem. 1981 Dec 25; 256(24):12731-9.
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  230. Barbieri JT, Carroll SF, Collier RJ, McCloskey JA. An endogenous dinucleotide bound to diphtheria toxin. Adenylyl-(3',5')-uridine 3'-monophosphate. J Biol Chem. 1981 Dec 10; 256(23):12247-51.
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  231. Kaplan DA, Naumovski L, Collier RJ. Chromogenic detection of antigen in bacteriophage plaques: a microplaque method applicable to large-scale screening. Gene. 1981 Apr; 13(3):211-20.
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  232. Kaplan DA, Naumovski L, Rothschild B, Collier RJ. Appendix: a model of plaque formation. Gene. 1981 Apr; 13(3):221-5.
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  233. Lory S, Carroll SF, Bernard PD, Collier RJ. Ligand interactions of diphtheria toxin. I. Binding and hydrolysis of NAD. J Biol Chem. 1980 Dec 25; 255(24):12011-5.
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  234. Lory S, Carroll SF, Collier RJ. Ligand interactions of diphtheria toxin. II. Relationships between the NAD site and the P site. J Biol Chem. 1980 Dec 25; 255(24):12016-9.
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  235. Carroll SF, Lory S, Collier RJ. Ligand interactions of diphtheria toxin. III. Direct photochemical cross-linking of ATP and NAD to toxin. J Biol Chem. 1980 Dec 25; 255(24):12020-4.
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  236. Mannhalter JW, Gilliland DG, Collier RJ. A hybrid toxin containing fragment A from diphtheria toxin linked to the B protomer of cholera toxin. Biochim Biophys Acta. 1980 Dec 16; 626(2):443-50.
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  237. Cawley DB, Herschman HR, Gilliland DG, Collier RJ. Epidermal growth factor-toxin A chain conjugates: EGF-ricin A is a potent toxin while EGF-diphtheria fragment A is nontoxic. Cell. 1980 Nov; 22(2 Pt 2):563-70.
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  238. Gilliland DG, Collier RJ. A model system involving anti-concanavalin A for antibody targeting of diphtheria toxin fragment A1. Cancer Res. 1980 Oct; 40(10):3564-9.
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  239. Gilliland DG, Steplewski Z, Collier RJ, Mitchell KF, Chang TH, Koprowski H. Antibody-directed cytotoxic agents: use of monoclonal antibody to direct the action of toxin A chains to colorectal carcinoma cells. Proc Natl Acad Sci U S A. 1980 Aug; 77(8):4539-43.
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  240. Lory S, Collier RJ. Expression of enzymic activity by exotoxin A from Pseudomonas aeruginosa. Infect Immun. 1980 May; 28(2):494-501.
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  241. Lory S, Collier RJ. Diphtheria toxin: nucleotide binding and toxin heterogeneity. Proc Natl Acad Sci U S A. 1980 Jan; 77(1):267-71.
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  242. DeLange RJ, Williams LC, Collier RJ. The amino acid sequence of fragment A, an enzymically active fragment of diphtheria toxin. I. The tryptic peptides from the maleylated protein. J Biol Chem. 1979 Jul 10; 254(13):5827-31.
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  243. Mekalanos JJ, Collier RJ, Romig WR. Enzymic activity of cholera toxin. II. Relationships to proteolytic processing, disulfide bond reduction, and subunit composition. J Biol Chem. 1979 Jul 10; 254(13):5855-61.
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  244. Mekalanos JJ, Collier RJ, Romig WR. Enzymic activity of cholera toxin. I. New method of assay and the mechanism of ADP-ribosyl transfer. J Biol Chem. 1979 Jul 10; 254(13):5849-54.
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  245. DeLange RJ, Williams LC, Drazin RE, Collier RJ. The amino acid sequence of fragment A, an enzymically active fragment of diphtheria toxin. III. The chymotryptic peptides, the peptides derived by cleavage at tryptophan residues, and the complete sequence of the protein. J Biol Chem. 1979 Jul 10; 254(13):5838-42.
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  246. Drazin RE, Collier RJ, Williams LC, DeLange RJ. The amino acid sequence of fragment A, an enzymically active fragment of diphtheria toxin. II. The cyanogen bromide peptides. J Biol Chem. 1979 Jul 10; 254(13):5832-7.
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  247. Collier RJ, Gilliland DG, Lory S. Structure-activity relationships in diphtheria toxin and exotoxin A from Pseudomonas aeruginosa. Prog Clin Biol Res. 1979; 31:751-9.
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  248. Gilliland DG, Collier RJ, Moehring JM, Moehring TJ. Chimeric toxins: toxic, disulfide-linked conjugate of concanavalin A with fragment A from diphtheria toxin. Proc Natl Acad Sci U S A. 1978 Nov; 75(11):5319-23.
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  249. Mekalanos JJ, Collier RJ, Romig WR. Purification of cholera toxin and its subunits: new methods of preparation and the use of hypertoxinogenic mutants. Infect Immun. 1978 May; 20(2):552-8.
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  250. Mekalanos JJ, Collier RJ, Romig WR. Affinity filters, a new approach to the isolation of tox mutants of Vibrio cholerae. Proc Natl Acad Sci U S A. 1978 Feb; 75(2):941-5.
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  251. Chung DW, Collier RJ. The mechanism of ADP-ribosylation of elongation factor 2 catalyzed by fragment A from diphtheria toxin. Biochim Biophys Acta. 1977 Aug 11; 483(2):248-57.
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  252. Chung DW, Collier RJ. Enzymatically active peptide from the adenosine diphosphate-ribosylating toxin of Pseudomonas aeruginosa. Infect Immun. 1977 Jun; 16(3):832-41.
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  253. Mekalanos JJ, Collier RJ, Romig WR. Simple method for purifying choleragenoid, the natural toxoid of Vibrio cholerae. Infect Immun. 1977 Jun; 16(3):789-95.
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  254. DeLange RJ, Drazin RE, Collier RJ. Amino-acid sequence of fragment A, an enzymically active fragment from diphtheria toxin. Proc Natl Acad Sci U S A. 1976 Jan; 73(1):69-72.
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  255. Collier RJ. Diphtheria toxin: mode of action and structure. Bacteriol Rev. 1975 Mar; 39(1):54-85.
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  256. Kandel J, Collier RJ, Chung DW. Interaction of fragment A from diphtheria toxin with nicotinamide adenine dinucleotide. J Biol Chem. 1974 Apr 10; 249(7):2088-97.
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  257. Traugh JA, Collier RJ. Interaction of transferase II with polynucleotides and inhibition of the interaction by guanosine nucleotides. Biochemistry. 1971 Jun 8; 10(12):2357-66.
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  258. Traugh JA, Collier RJ. Interaction of transferase II with the 60 s ribosomal subunit. FEBS Lett. 1971 May 20; 14(5):285-288.
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  259. Drazin R, Kandel J, Collier RJ. Structure and activity of diphtheria toxin. II. Attack by trypsin at a specific site within the intact toxin molecule. J Biol Chem. 1971 Mar 10; 246(5):1504-10.
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  260. Collier RJ, Kandel J. Structure and activity of diphtheria toxin. I. Thiol-dependent dissociation of a fraction of toxin into enzymically active and inactive fragments. J Biol Chem. 1971 Mar 10; 246(5):1496-503.
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  261. Traugh JA, Collier RJ. Binding of transfer factor II to ribosomal RNA and inhibition of the binding by guanosine nucleotides. Biochem Biophys Res Commun. 1970 Sep 30; 40(6):1437-44.
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  262. Collier RJ, Cole HA. Diphtheria toxin subunit active in vitro. Science. 1969 Jun 6; 164(3884):1179-81.
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  263. Collier RJ, Traugh JA. Inactivation of aminoacyl transferase II by diphtheria toxin. Cold Spring Harb Symp Quant Biol. 1969; 34:589-94.
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  264. Collier RJ. Effect of diphtheria toxin on protein synthesis: inactivation of one of the transfer factors. J Mol Biol. 1967 Apr 14; 25(1):83-98.
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  265. COLLIER RJ, PAPPENHEIMER AM. STUDIES ON THE MODE OF ACTION OF DIPHTHERIA TOXIN. I. PHOSPHORYLATED INTERMEDIATES IN NORMAL AND INTOXICATED HELA CELLS. J Exp Med. 1964 Dec 1; 120:1007-18.
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  266. COLLIER RJ, PAPPENHEIMER AM. STUDIES ON THE MODE OF ACTION OF DIPHTHERIA TOXIN. II. EFFECT OF TOXIN ON AMINO ACID INCORPORATION IN CELL-FREE SYSTEMS. J Exp Med. 1964 Dec 1; 120:1019-39.
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  267. Pappenheimer AM Jr, Collier RJ, Miller PA. The effect of diphtheria toxin on the metabolism of mammalian cells in tissue culture. Cell Culture in the Study of Bacterial Disease. M Solotorovsky, editor. 1963; 21-35.
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