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Paul Joseph Anderson, M.D., PH.D.

TitleK. Frank Austen Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Women's Hospital
Smith Building 652C
75 Francis St
Boston MA 02115
Phone617/525-1202
Fax617/525-1310

 Mentoring 
 completed student projects
Examining the Role of TIA-1 in the cyclic AMP regulated TNF alpha expression of activated macrophages
Summer, 06/18/02 - 08/20/02

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Simarro M, Giannattasio G, De la Fuente MA, Benarafa C, Subramanian KK, Ishizawar R, Balestrieri B, Andersson EM, Luo HR, Orduña A, Boyce J, Anderson P. Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation. J Immunol. 2010 May 1; 184(9):5325-32.
    View in: PubMed
  2. Li CH, Ohn T, Ivanov P, Tisdale S, Anderson P. eIF5A promotes translation elongation, polysome disassembly and stress granule assembly. PLoS One. 2010; 5(4):e9942.
    View in: PubMed
  3. O'Brien CE, Anderson PJ, Stowe CD. Use of the chloride channel activator lubiprostone for constipation in adults with cystic fibrosis: a case series. Ann Pharmacother. 2010 Mar; 44(3):577-81.
    View in: PubMed
  4. Emara MM, Ivanov P, Hickman T, Dawra N, Tisdale S, Kedersha N, Hu GF, Anderson P. Angiogenin-induced tRNA-derived stress-induced RNAs promote stress-induced stress granule assembly. J Biol Chem. 2010 Apr 2; 285(14):10959-68.
    View in: PubMed
  5. Anderson P. Post-transcriptional regulons coordinate the initiation and resolution of inflammation. Nat Rev Immunol. 2010 Jan; 10(1):24-35.
    View in: PubMed
  6. Karpel JP, Peters JI, Szema AM, Smith B, Anderson PJ. Differences in physicians' self-reported knowledge of, attitudes toward, and responses to the black box warning on long-acting beta-agonists. Ann Allergy Asthma Immunol. 2009 Oct; 103(4):304-10.
    View in: PubMed
  7. Anderson P, Kedersha N. RNA granules: post-transcriptional and epigenetic modulators of gene expression. Nat Rev Mol Cell Biol. 2009 Jun; 10(6):430-6.
    View in: PubMed
  8. Anderson P, Kedersha N. Stress granules. Curr Biol. 2009 May 26; 19(10):R397-8.
    View in: PubMed
  9. Yamasaki S, Ivanov P, Hu GF, Anderson P. Angiogenin cleaves tRNA and promotes stress-induced translational repression. J Cell Biol. 2009 Apr 6; 185(1):35-42.
    View in: PubMed
  10. Ohn T, Kedersha N, Hickman T, Tisdale S, Anderson P. A functional RNAi screen links O-GlcNAc modification of ribosomal proteins to stress granule and processing body assembly. Nat Cell Biol. 2008 Oct; 10(10):1224-31.
    View in: PubMed
  11. Pinz I, Wax SD, Anderson P, Ingwall JS. Low over-expression of TNFalpha in the mouse heart increases contractile performance via TNFR1. J Cell Biochem. 2008 Sep 1; 105(1):99-107.
    View in: PubMed
  12. Anderson P. Post-transcriptional control of cytokine production. Nat Immunol. 2008 Apr; 9(4):353-9.
    View in: PubMed
  13. Yamasaki S, Anderson P. Reprogramming mRNA translation during stress. Curr Opin Cell Biol. 2008 Apr; 20(2):222-6.
    View in: PubMed
  14. Anderson P, Kedersha N. Stress granules: the Tao of RNA triage. Trends Biochem Sci. 2008 Mar; 33(3):141-50.
    View in: PubMed
  15. Stoecklin G, Tenenbaum SA, Mayo T, Chittur SV, George AD, Baroni TE, Blackshear PJ, Anderson P. Genome-wide analysis identifies interleukin-10 mRNA as target of tristetraprolin. J Biol Chem. 2008 Apr 25; 283(17):11689-99.
    View in: PubMed
  16. Kedersha N, Tisdale S, Hickman T, Anderson P. Real-time and quantitative imaging of mammalian stress granules and processing bodies. Methods Enzymol. 2008; 448:521-52.
    View in: PubMed
  17. Yamasaki S, Stoecklin G, Kedersha N, Simarro M, Anderson P. T-cell intracellular antigen-1 (TIA-1)-induced translational silencing promotes the decay of selected mRNAs. J Biol Chem. 2007 Oct 12; 282(41):30070-7.
    View in: PubMed
  18. Simarro M, Mauger D, Rhee K, Pujana MA, Kedersha NL, Yamasaki S, Cusick ME, Vidal M, Garcia-Blanco MA, Anderson P. Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing. Proc Natl Acad Sci U S A. 2007 Jul 3; 104(27):11370-5.
    View in: PubMed
  19. Anderson P, Kedersha N. On again, off again: the SRC-3 transcriptional coactivator moonlights as a translational corepressor. Mol Cell. 2007 Mar 23; 25(6):796-7.
    View in: PubMed
  20. Kedersha N, Anderson P. Mammalian stress granules and processing bodies. Methods Enzymol. 2007; 431:61-81.
    View in: PubMed
  21. Sun L, Stoecklin G, Van Way S, Hinkovska-Galcheva V, Guo RF, Anderson P, Shanley TP. Tristetraprolin (TTP)-14-3-3 complex formation protects TTP from dephosphorylation by protein phosphatase 2a and stabilizes tumor necrosis factor-alpha mRNA. J Biol Chem. 2007 Feb 9; 282(6):3766-77.
    View in: PubMed
  22. Izumi Y, Ida H, Huang M, Iwanaga N, Tanaka F, Aratake K, Arima K, Tamai M, Kamachi M, Nakamura H, Origuchi T, Kawakami A, Anderson P, Eguchi K. Characterization of peripheral natural killer cells in primary Sjögren's syndrome: impaired NK cell activity and low NK cell number. J Lab Clin Med. 2006 May; 147(5):242-9.
    View in: PubMed
  23. Anderson P, Kedersha N. RNA granules. J Cell Biol. 2006 Mar 13; 172(6):803-8.
    View in: PubMed
  24. Stoecklin G, Mayo T, Anderson P. ARE-mRNA degradation requires the 5'-3' decay pathway. EMBO Rep. 2006 Jan; 7(1):72-7.
    View in: PubMed
  25. Stoecklin G, Anderson P. Posttranscriptional mechanisms regulating the inflammatory response. Adv Immunol. 2006; 89:1-37.
    View in: PubMed
  26. Anderson P. A Place for RNAi. Dev Cell. 2005 Sep; 9(3):311-2.
    View in: PubMed
  27. Anderson PJ. History of aerosol therapy: liquid nebulization to MDIs to DPIs. Respir Care. 2005 Sep; 50(9):1139-50.
    View in: PubMed
  28. Wax SD, Nakamura H, Anderson PJ. The tumor necrosis factor-alpha AU-rich element inhibits the stable association of the 40S ribosomal subunit with RNA transcripts. Biochem Biophys Res Commun. 2005 Aug 12; 333(4):1100-6.
    View in: PubMed
  29. Kedersha N, Stoecklin G, Ayodele M, Yacono P, Lykke-Andersen J, Fritzler MJ, Scheuner D, Kaufman RJ, Golan DE, Anderson P. Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. J Cell Biol. 2005 Jun 20; 169(6):871-84.
    View in: PubMed
  30. Anderson PJ. Tumor necrosis factor inhibitors: clinical implications of their different immunogenicity profiles. Semin Arthritis Rheum. 2005 Apr; 34(5 Suppl1):19-22.
    View in: PubMed
  31. Anderson P, Louie J, Lau A, Broder M. Mechanisms of differential immunogenicity of tumor necrosis factor inhibitors. Curr Rheumatol Rep. 2005 Mar; 7(1):3-9.
    View in: PubMed
  32. Dolovich MB, Ahrens RC, Hess DR, Anderson P, Dhand R, Rau JL, Smaldone GC, Guyatt G. Device selection and outcomes of aerosol therapy: Evidence-based guidelines: American College of Chest Physicians/American College of Asthma, Allergy, and Immunology. Chest. 2005 Jan; 127(1):335-71.
    View in: PubMed
  33. Li W, Simarro M, Kedersha N, Anderson P. FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression. Mol Cell Biol. 2004 Dec; 24(24):10718-32.
    View in: PubMed
  34. Gilks N, Kedersha N, Ayodele M, Shen L, Stoecklin G, Dember LM, Anderson P. Stress granule assembly is mediated by prion-like aggregation of TIA-1. Mol Biol Cell. 2004 Dec; 15(12):5383-98.
    View in: PubMed
  35. Li W, Kedersha N, Chen S, Gilks N, Lee G, Anderson P. FAST is a BCL-X(L)-associated mitochondrial protein. Biochem Biophys Res Commun. 2004 May 21; 318(1):95-102.
    View in: PubMed
  36. Anderson P, Phillips K, Stoecklin G, Kedersha N. Post-transcriptional regulation of proinflammatory proteins. J Leukoc Biol. 2004 Jul; 76(1):42-7.
    View in: PubMed
  37. Stoecklin G, Stubbs T, Kedersha N, Wax S, Rigby WF, Blackwell TK, Anderson P. MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay. EMBO J. 2004 Mar 24; 23(6):1313-24.
    View in: PubMed
  38. Phillips K, Kedersha N, Shen L, Blackshear PJ, Anderson P. Arthritis suppressor genes TIA-1 and TTP dampen the expression of tumor necrosis factor alpha, cyclooxygenase 2, and inflammatory arthritis. Proc Natl Acad Sci U S A. 2004 Feb 17; 101(7):2011-6.
    View in: PubMed
  39. Anderson PJ. Aerosol therapy: assume nothing and require data. Respir Care. 2003 Nov; 48(11):1016-8.
    View in: PubMed
  40. Eckles M, Anderson P. Cor pulmonale in cystic fibrosis. Semin Respir Crit Care Med. 2003 Jun; 24(3):323-30.
    View in: PubMed
  41. Wax S, Piecyk M, Maritim B, Anderson P. Geldanamycin inhibits the production of inflammatory cytokines in activated macrophages by reducing the stability and translation of cytokine transcripts. Arthritis Rheum. 2003 Feb; 48(2):541-50.
    View in: PubMed
  42. Joguparthi V, Breen P, Compadre C, Zhou X, Gann L, Hiller FC, Anderson P. Effect of propellant on the pharmacokinetics and pharmacodynamics of inhaled albuterol in asthmatic subjects. J Aerosol Med. 2003; 16(1):47-53.
    View in: PubMed
  43. Anderson P, Kedersha N. Stressful initiations. J Cell Sci. 2002 Aug 15; 115(Pt 16):3227-34.
    View in: PubMed
  44. Anderson P, Kedersha N. Visibly stressed: the role of eIF2, TIA-1, and stress granules in protein translation. Cell Stress Chaperones. 2002 Apr; 7(2):213-21.
    View in: PubMed
  45. Kedersha N, Chen S, Gilks N, Li W, Miller IJ, Stahl J, Anderson P. Evidence that ternary complex (eIF2-GTP-tRNA(i)(Met))-deficient preinitiation complexes are core constituents of mammalian stress granules. Mol Biol Cell. 2002 Jan; 13(1):195-210.
    View in: PubMed
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