James Chodosh, M.D.
|Title||David Glendenning Cogan Professor of Ophthalmology in the field of Cornea and External Disease|
|Institution||Massachusetts Eye and Ear Infirmary|
|Address||Massachusetts Eye & Ear Infrm|
243 Charles St
Boston MA 02114
Available: 08/01/12, Expires: 07/01/15
Our laboratory’s long-term goal is to develop new information-based therapies for ocular surface inflammation due to viral infections. We study the molecular pathogenesis of adenoviruses in ocular infection. Ongoing projects include studies on the role of keratocytes, the resident cells of the eye’s corneal stroma, in the chemokine-driven innate immune responses to viral infection of the cornea. Specifically, we study signal transduction events in response to infection with adenoviruses in cultured human keratocytes, living mice, and complex tissue culture reconstructions of the human cornea, at the nucleic acid, protein, and cellular levels, and how those signaling events influence the expression of pro-inflammatory mediators. Another project involves understanding how previously uncharacterized regions of the adenoviral genome contribute to viral pathogenesis. This work involves whole genome sequencing, bioinformatics, and proteomics. The research assistant will work at the graduate level with direct supervision by the principal investigator and co-investigator.
Available: 07/01/11, Expires: 06/30/15
Human adenoviruses within species D evolve principally through homologous recombination during co-infections. Recently, species D adenoviruses have undergone a rapid expansion, with severe consequences for infected patients. The student will develop in vitro models of viral co-infection to identify basic mechanisms of genetic recombination among human adenoviruses. This project may involve basic bioinformatics as well as wet bench methods.
Sterile Vitritis in the Setting of a Boston Keratoprosthesis
Full Time/Year Long, 07/01/13 - 06/30/14
Identifying Different Roles of Cornea Stromal Cells in the Adenovirus 37 Keratitis Mouse Model
Summer, 06/15/09 - 07/31/09
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