Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

Luminita Pojoga, Ph.D.

TitleAssistant Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham & Women's Hospital
Endocrinology Div - RFB 2, room 214
221 Longwood Ave
Boston MA 02115
Phone617/278-0415
Fax617/732-5764

 Biography 
 awards and honors
1998 - 2000Greenville Hospital System Biomedical Research Graduate Fellowship Award
2000 - R.C. Edwards Research Fellowship Award
2004 - 2006Ruth L. Kirschstein National Service Award
2007 - Aldosterone Conference - Young Investigator Award Finalist
2007 - Endocrine Fellows Day Award
2007 - 2010Scientist Development Grant
2008 - 2010KL2 MeRIT Award
2010 - New Investigator Award

 Mentoring 
 current student opportunities
Available: 09/01/11, Expires: 08/31/13

The renin-angiotensin-aldosterone system (RAAS) and the adrenergic system are two important regulators of blood pressure homeostasis. We have identified two coding variants in the beta-2 adrenergic receptor (B2AR) gene, which confers salt sensitivity of the blood pressure and increased aldosterone levels in hypertensive humans. Our lab is currently interested in deciphering the effects of these two B2AR genetic variants in the adrenal gland. The student will use adrenocortical cells transfected with wild type B2AR or with B2AR harboring one or both B2AR variants above. To determine whether one of these B2AR variants confers an altered response to beta-2 stimulation, the student will analyze the aldosterone secretion from these cells after treatment with B2AR-specific agonists and antagonists.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Krug AW, Tille E, Sun B, Pojoga L, Williams J, Chamarthi B, Lichtman AH, Hopkins PN, Adler GK, Williams GH. Lysine-specific demethylase-1 modifies the age effect on blood pressure sensitivity to dietary salt intake. Age (Dordr). 2012 Oct 2.
    View in: PubMed
  2. Chuengsamarn S, Garza AE, Krug AW, Romero JR, Adler GK, Williams GH, Pojoga LH. Direct renin inhibition modulates insulin resistance in caveolin-1-deficient mice. Metabolism. 2013 Feb; 62(2):275-81.
    View in: PubMed
  3. Williams JS, Chamarthi B, Goodarzi MO, Pojoga LH, Sun B, Garza AE, Raby BA, Adler GK, Hopkins PN, Brown NJ, Jeunemaitre X, Ferri C, Fang R, Leonor T, Cui J, Guo X, Taylor KD, Ida Chen YD, Xiang A, Raffel LJ, Buchanan TA, Rotter JI, Williams GH, Shi Y. Lysine-specific demethylase 1: an epigenetic regulator of salt-sensitive hypertension. Am J Hypertens. 2012 Jul; 25(7):812-7.
    View in: PubMed
  4. Pojoga LH, Coutinho P, Rivera A, Yao TM, Maldonado ER, Youte R, Adler GK, Williams J, Turchin A, Williams GH, Romero JR. Activation of the mineralocorticoid receptor increases striatin levels. Am J Hypertens. 2012 Feb; 25(2):243-9.
    View in: PubMed
  5. Pojoga LH, Williams JS, Yao TM, Kumar A, Raffetto JD, do Nascimento GR, Reslan OM, Adler GK, Williams GH, Shi Y, Khalil RA. Histone demethylase LSD1 deficiency during high-salt diet is associated with enhanced vascular contraction, altered NO-cGMP relaxation pathway, and hypertension. Am J Physiol Heart Circ Physiol. 2011 Nov; 301(5):H1862-71.
    View in: PubMed
  6. Ricchiuti V, Lapointe N, Pojoga L, Yao T, Tran L, Williams GH, Adler GK. Dietary sodium intake regulates angiotensin II type 1, mineralocorticoid receptor, and associated signaling proteins in heart. J Endocrinol. 2011 Oct; 211(1):47-54.
    View in: PubMed
  7. Pojoga LH, Underwood PC, Goodarzi MO, Williams JS, Adler GK, Jeunemaitre X, Hopkins PN, Raby BA, Lasky-Su J, Sun B, Cui J, Guo X, Taylor KD, Chen YD, Xiang A, Raffel LJ, Buchanan TA, Rotter JI, Williams GH. Variants of the caveolin-1 gene: a translational investigation linking insulin resistance and hypertension. J Clin Endocrinol Metab. 2011 Aug; 96(8):E1288-92.
    View in: PubMed
  8. Sun B, Williams JS, Pojoga L, Chamarthi B, Lasky-Su J, Raby BA, Hopkins PN, Jeunemaitre X, Brown NJ, Ferri C, Williams GH. Renin gene polymorphism: its relationship to hypertension, renin levels and vascular responses. J Renin Angiotensin Aldosterone Syst. 2011 Dec; 12(4):564-71.
    View in: PubMed
  9. Krug AW, Pojoga LH, Williams GH, Adler GK. Cell membrane-associated mineralocorticoid receptors? New evidence. Hypertension. 2011 Jun; 57(6):1019-25.
    View in: PubMed
  10. Vaidya A, Forman JP, Underwood PC, Hopkins PN, Williams GH, Pojoga LH, Williams JS. The influence of body mass index and renin-angiotensin-aldosterone system activity on the relationship between 25-hydroxyvitamin D and adiponectin in Caucasian men. Eur J Endocrinol. 2011 Jun; 164(6):995-1002.
    View in: PubMed
  11. Vaidya A, Pojoga L, Underwood PC, Forman JP, Hopkins PN, Williams GH, Williams JS. The association of plasma resistin with dietary sodium manipulation, the renin-angiotensin-aldosterone system, and 25-hydroxyvitamin D3 in human hypertension. Clin Endocrinol (Oxf). 2011 Mar; 74(3):294-9.
    View in: PubMed
  12. Underwood PC, Sun B, Williams JS, Pojoga LH, Raby B, Lasky-Su J, Hunt S, Hopkins PN, Jeunemaitre X, Adler GK, Williams GH. The association of the angiotensinogen gene with insulin sensitivity in humans: a tagging single nucleotide polymorphism and haplotype approach. Metabolism. 2011 Aug; 60(8):1150-7.
    View in: PubMed
  13. Underwood PC, Sun B, Williams JS, Pojoga LH, Chamarthi B, Lasky-Su J, Raby BA, Hopkins PN, Jeunemaitre X, Brown NJ, Adler GK, Williams GH. The relationship between peroxisome proliferator-activated receptor-gamma and renin: a human genetics study. J Clin Endocrinol Metab. 2010 Sep; 95(9):E75-9.
    View in: PubMed
  14. Pojoga LH, Adamová Z, Kumar A, Stennett AK, Romero JR, Adler GK, Williams GH, Khalil RA. Sensitivity of NOS-dependent vascular relaxation pathway to mineralocorticoid receptor blockade in caveolin-1-deficient mice. Am J Physiol Heart Circ Physiol. 2010 Jun; 298(6):H1776-88.
    View in: PubMed
  15. Pojoga LH, Romero JR, Yao TM, Loutraris P, Ricchiuti V, Coutinho P, Guo C, Lapointe N, Stone JR, Adler GK, Williams GH. Caveolin-1 ablation reduces the adverse cardiovascular effects of N-omega-nitro-L-arginine methyl ester and angiotensin II. Endocrinology. 2010 Mar; 151(3):1236-46.
    View in: PubMed
  16. Pojoga LH, Yao TM, Sinha S, Ross RL, Lin JC, Raffetto JD, Adler GK, Williams GH, Khalil RA. Effect of dietary sodium on vasoconstriction and eNOS-mediated vascular relaxation in caveolin-1-deficient mice. Am J Physiol Heart Circ Physiol. 2008 Mar; 294(3):H1258-65.
    View in: PubMed
  17. Pojoga L, Kolatkar NS, Williams JS, Perlstein TS, Jeunemaitre X, Brown NJ, Hopkins PN, Raby BA, Williams GH. Beta-2 adrenergic receptor diplotype defines a subset of salt-sensitive hypertension. Hypertension. 2006 Nov; 48(5):892-900.
    View in: PubMed
  18. Guo C, Martinez-Vasquez D, Mendez GP, Toniolo MF, Yao TM, Oestreicher EM, Kikuchi T, Lapointe N, Pojoga L, Williams GH, Ricchiuti V, Adler GK. Mineralocorticoid receptor antagonist reduces renal injury in rodent models of types 1 and 2 diabetes mellitus. Endocrinology. 2006 Nov; 147(11):5363-73.
    View in: PubMed
  19. Pojoga LH, Moose JE, Hilderman RH. Characterization of the interaction of P1,P4-diadenosine 5'-tetraphosphate with luciferase. Biochem Biophys Res Commun. 2004 Mar 12; 315(3):756-62.
    View in: PubMed
  20. Pojoga LH, Haghiac ML, Moose JE, Hilderman RH. Determination of ATP impurity in adenine dinucleotides. Nucleosides Nucleotides Nucleic Acids. 2004; 23(3):581-98.
    View in: PubMed
  21. Pojoga LH, Hilderman RH. A theoretical and experimental approach to the use of single wavelength calcium indicators. J Theor Biol. 2003 Apr 21; 221(4):543-57.
    View in: PubMed
  22. Pojoga LH, Haghiac M, Hilderman RH. Inhibition by adenine dinucleotides of ATP-induced prostacyclin release by bovine aortic endothelial cells. Biochem Pharmacol. 2002 Aug 1; 64(3):405-12.
    View in: PubMed
  23. Haghiac M, Pojoga LH, Hilderman RH. Studies on the effect of diadenlyated nucleotides on calcium mobilization and prostacyclin synthesis in bovine aortic endothelial cells. Cell Signal. 2001 Feb; 13(2):145-50.
    View in: PubMed
  24. Hilderman RH, Pojoga LH, Haghiac M, Cooper HM, Rosenberg CR. Rec Res Dev in Biophys Biochem. The role of extracellular adenosine dinucleotides as vasoregulators. 2001; 1:59-76.
  25. Hilderman RH, Casey TE, Pojoga LH. P(1),P(4)-Diadenosine 5'-tetraphosphate modulates l-arginine and l-citrulline uptake by bovine aortic endothelial cells. Arch Biochem Biophys. 2000 Mar 1; 375(1):124-30.
    View in: PubMed
  26. Pojoga L, Gautier S, Blanc H, Guyene TT, Poirier O, Cambien F, Benetos A. Genetic determination of plasma aldosterone levels in essential hypertension. Am J Hypertens. 1998 Jul; 11(7):856-60.
    View in: PubMed
  27. Raicu M, Pojoga L, Simionescu N, Simionescu M. The effect of ACE inhibitors on atheroma formation is potentiated by association with a calcium channel blocker. A biochemical and ultrastructural study. J Submicrosc Cytol Pathol. 1997 Jul; 29(3):317-28.
    View in: PubMed
  28. Raicu M, Pojoga L, Simionescu N, Simionescu M. Differential effect of two calcium channel blockers--nifedipine and diltiazem--on atherogenesis in hypercholesterolemic hamster. J Submicrosc Cytol Pathol. 1996 Apr; 28(2):265-75.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Pojoga's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
See all (184) concept(s)
_
Co-Authors
See all (15) people
_
Similar People
See all (60) people
_
Same Department
Search Department
Physical Neighbors
_