Luminita Pojoga, Ph.D.
|Title||Assistant Professor of Medicine|
|Institution||Brigham and Women's Hospital|
|Address||Brigham & Women's Hospital|
Endocrinology Div - RFB 2, room 214
221 Longwood Ave
Boston MA 02115
2000||Greenville Hospital System Biomedical Research Graduate Fellowship Award|
||R.C. Edwards Research Fellowship Award|
2006||Ruth L. Kirschstein National Service Award|
||Aldosterone Conference - Young Investigator Award Finalist|
||Endocrine Fellows Day Award|
2010||Scientist Development Grant|
2010||KL2 MeRIT Award|
||New Investigator Award|
Available: 09/01/11, Expires: 08/31/13
The renin-angiotensin-aldosterone system (RAAS) and the adrenergic system are two important regulators of blood pressure homeostasis. We have identified two coding variants in the beta-2 adrenergic receptor (B2AR) gene, which confers salt sensitivity of the blood pressure and increased aldosterone levels in hypertensive humans.
Our lab is currently interested in deciphering the effects of these two B2AR genetic variants in the adrenal gland. The student will use adrenocortical cells transfected with wild type B2AR or with B2AR harboring one or both B2AR variants above. To determine whether one of these B2AR variants confers an altered response to beta-2 stimulation, the student will analyze the aldosterone secretion from these cells after treatment with B2AR-specific agonists and antagonists.
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