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Hanne M. Kooy, PH.D.

TitleAssociate Professor of Radiation Oncology
InstitutionMassachusetts General Hospital
DepartmentRadiation Oncology
AddressMassachusetts General Hospital
Radiation Oncology - NPTC
55 Fruit St
Boston MA 02114
Phone617/724-9997
Fax617/724-9532

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Clasie BM, Flanz JB, Kooy HM. Interpolation of tabulated proton Bragg peaks. Phys Med Biol. 2012 Nov 7; 57(21):N405-9.
    View in: PubMed
  2. Clasie BM, Sharp GC, Seco J, Flanz JB, Kooy HM. Numerical solutions of the ?-index in two and three dimensions. Phys Med Biol. 2012 Nov 7; 57(21):6981-97.
    View in: PubMed
  3. Butterworth KT, McGarry CK, Clasie B, Carabe-Fernandez A, Schuemann J, Depauw N, Tang S, McMahon SJ, Schettino G, O'Sullivan JM, Lu HM, Kooy H, Paganetti H, Hounsell AR, Held KD, Prise KM. Relative biological effectiveness (RBE) and out-of-field cell survival responses to passive scattering and pencil beam scanning proton beam deliveries. Phys Med Biol. 2012 Oct 21; 57(20):6671-80.
    View in: PubMed
  4. Dowdell SJ, Clasie B, Depauw N, Metcalfe P, Rosenfeld AB, Kooy HM, Flanz JB, Paganetti H. Monte Carlo study of the potential reduction in out-of-field dose using a patient-specific aperture in pencil beam scanning proton therapy. Phys Med Biol. 2012 May 21; 57(10):2829-42.
    View in: PubMed
  5. Clasie B, Depauw N, Fransen M, Gomà C, Panahandeh HR, Seco J, Flanz JB, Kooy HM. Golden beam data for proton pencil-beam scanning. Phys Med Biol. 2012 Mar 7; 57(5):1147-58.
    View in: PubMed
  6. Chen W, Unkelbach J, Trofimov A, Madden T, Kooy H, Bortfeld T, Craft D. Including robustness in multi-criteria optimization for intensity-modulated proton therapy. Phys Med Biol. 2012 Feb 7; 57(3):591-608.
    View in: PubMed
  7. Hattangadi JA, Rombi B, Yock TI, Broussard G, Friedmann AM, Huang M, Chen YL, Lu HM, Kooy H, MacDonald SM. Proton radiotherapy for high-risk pediatric neuroblastoma: early outcomes and dose comparison. Int J Radiat Oncol Biol Phys. 2012 Jul 1; 83(3):1015-22.
    View in: PubMed
  8. Chen W, Craft D, Madden TM, Zhang K, Kooy HM, Herman GT. A fast optimization algorithm for multicriteria intensity modulated proton therapy planning. Med Phys. 2010 Sep; 37(9):4938-45.
    View in: PubMed
  9. Paganetti H, Kooy H. Proton radiation in the management of localized cancer. Expert Rev Med Devices. 2010 Mar; 7(2):275-85.
    View in: PubMed
  10. Kooy HM, Clasie BM, Lu HM, Madden TM, Bentefour H, Depauw N, Adams JA, Trofimov AV, Demaret D, Delaney TF, Flanz JB. A case study in proton pencil-beam scanning delivery. Int J Radiat Oncol Biol Phys. 2010 Feb 1; 76(2):624-30.
    View in: PubMed
  11. Clasie B, Wroe A, Kooy H, Depauw N, Flanz J, Paganetti H, Rosenfeld A. Assessment of out-of-field absorbed dose and equivalent dose in proton fields. Med Phys. 2010 Jan; 37(1):311-21.
    View in: PubMed
  12. Engelsman M, Lu HM, Herrup D, Bussiere M, Kooy HM. Commissioning a passive-scattering proton therapy nozzle for accurate SOBP delivery. Med Phys. 2009 Jun; 36(6):2172-80.
    View in: PubMed
  13. Daartz J, Bangert M, Bussière MR, Engelsman M, Kooy HM. Characterization of a mini-multileaf collimator in a proton beamline. Med Phys. 2009 May; 36(5):1886-94.
    View in: PubMed
  14. Wroe A, Clasie B, Kooy H, Flanz J, Schulte R, Rosenfeld A. Out-of-field dose equivalents delivered by passively scattered therapeutic proton beams for clinically relevant field configurations. Int J Radiat Oncol Biol Phys. 2009 Jan 1; 73(1):306-13.
    View in: PubMed
  15. Suit H, Kooy H, Trofimov A, Farr J, Munzenrider J, DeLaney T, Loeffler J, Clasie B, Safai S, Paganetti H. Should positive phase III clinical trial data be required before proton beam therapy is more widely adopted? No. Radiother Oncol. 2008 Feb; 86(2):148-53.
    View in: PubMed
  16. Lu HM, Brett R, Engelsman M, Slopsema R, Kooy H, Flanz J. Sensitivities in the production of spread-out Bragg peak dose distributions by passive scattering with beam current modulation. Med Phys. 2007 Oct; 34(10):3844-53.
    View in: PubMed
  17. Lu HM, Brett R, Sharp G, Safai S, Jiang S, Flanz J, Kooy H. A respiratory-gated treatment system for proton therapy. Med Phys. 2007 Aug; 34(8):3273-8.
    View in: PubMed
  18. Slopsema RL, Kooy HM. Incorporation of the aperture thickness in proton pencil-beam dose calculations. Phys Med Biol. 2006 Nov 7; 51(21):5441-53.
    View in: PubMed
  19. Lu HM, Kooy H. Optimization of current modulation function for proton spread-out Bragg peak fields. Med Phys. 2006 May; 33(5):1281-7.
    View in: PubMed
  20. Engelsman M, Rietzel E, Kooy HM. Four-dimensional proton treatment planning for lung tumors. Int J Radiat Oncol Biol Phys. 2006 Apr 1; 64(5):1589-95.
    View in: PubMed
  21. Kooy HM, Rosenthal SJ, Engelsman M, Mazal A, Slopsema RL, Paganetti H, Flanz JB. The prediction of output factors for spread-out proton Bragg peak fields in clinical practice. Phys Med Biol. 2005 Dec 21; 50(24):5847-56.
    View in: PubMed
  22. Engelsman M, Kooy HM. Target volume dose considerations in proton beam treatment planning for lung tumors. Med Phys. 2005 Dec; 32(12):3549-57.
    View in: PubMed
  23. Engelsman M, Rosenthal SJ, Michaud SL, Adams JA, Schneider RJ, Bradley SG, Flanz JB, Kooy HM. Intra- and interfractional patient motion for a variety of immobilization devices. Med Phys. 2005 Nov; 32(11):3468-74.
    View in: PubMed
  24. Levin WP, Kooy H, Loeffler JS, DeLaney TF. Proton beam therapy. Br J Cancer. 2005 Oct 17; 93(8):849-54.
    View in: PubMed
  25. Chan AW, Black P, Ojemann RG, Barker FG, Kooy HM, Lopes VV, McKenna MJ, Shrieve DC, Martuza RL, Loeffler JS. Stereotactic radiotherapy for vestibular schwannomas: favorable outcome with minimal toxicity. Neurosurgery. 2005 Jul; 57(1):60-70; discussion 60-70.
    View in: PubMed
  26. Marcus KJ, Goumnerova L, Billett AL, Lavally B, Scott RM, Bishop K, Xu R, Young Poussaint T, Kieran M, Kooy H, Pomeroy SL, Tarbell NJ. Stereotactic radiotherapy for localized low-grade gliomas in children: final results of a prospective trial. Int J Radiat Oncol Biol Phys. 2005 Feb 1; 61(2):374-9.
    View in: PubMed
  27. Paganetti H, Jiang H, Lee SY, Kooy HM. Accurate Monte Carlo simulations for nozzle design, commissioning and quality assurance for a proton radiation therapy facility. Med Phys. 2004 Jul; 31(7):2107-18.
    View in: PubMed
  28. St Clair WH, Adams JA, Bues M, Fullerton BC, La Shell S, Kooy HM, Loeffler JS, Tarbell NJ. Advantage of protons compared to conventional X-ray or IMRT in the treatment of a pediatric patient with medulloblastoma. Int J Radiat Oncol Biol Phys. 2004 Mar 1; 58(3):727-34.
    View in: PubMed
  29. D'amico AV, Tempany CM, Schultz D, Cormack RA, Hurwitz M, Beard C, Albert M, Kooy H, Jolesz F, Richie JP. Comparing PSA outcome after radical prostatectomy or magnetic resonance imaging-guided partial prostatic irradiation in select patients with clinically localized adenocarcinoma of the prostate. Urology. 2003 Dec; 62(6):1063-7.
    View in: PubMed
  30. Kooy HM, Schaefer M, Rosenthal S, Bortfeld T. Monitor unit calculations for range-modulated spread-out Bragg peak fields. Phys Med Biol. 2003 Sep 7; 48(17):2797-808.
    View in: PubMed
  31. Albert M, Tempany CM, Schultz D, Chen MH, Cormack RA, Kumar S, Hurwitz MD, Beard C, Tuncali K, O'Leary M, Topulos GP, Valentine K, Lopes L, Kanan A, Kacher D, Rosato J, Kooy H, Jolesz F, Carr-Locke DL, Richie JP, D'Amico AV. Late genitourinary and gastrointestinal toxicity after magnetic resonance image-guided prostate brachytherapy with or without neoadjuvant external beam radiation therapy. Cancer. 2003 Sep 1; 98(5):949-54.
    View in: PubMed
  32. Mechalakos JG, Mageras GS, Zelefsky MJ, Lyass O, van Herk M, Kooy HM, Leibel SA, Ling CC. Time trends in organ position and volume in patients receiving prostate three-dimensional conformal radiotherapy. Radiother Oncol. 2002 Mar; 62(3):261-5.
    View in: PubMed
  33. Zissiadis Y, Dutton S, Kieran M, Goumnerova L, Scott RM, Kooy HM, Tarbell NJ. Stereotactic radiotherapy for pediatric intracranial germ cell tumors. Int J Radiat Oncol Biol Phys. 2001 Sep 1; 51(1):108-12.
    View in: PubMed
  34. Hodgson DC, Goumnerova LC, Loeffler JS, Dutton S, Black PM, Alexander E, Xu R, Kooy H, Silver B, Tarbell NJ. Radiosurgery in the management of pediatric brain tumors. Int J Radiat Oncol Biol Phys. 2001 Jul 15; 50(4):929-35.
    View in: PubMed
  35. Cormack RA, Kooy H, Tempany CM, D'Amico AV. A clinical method for real-time dosimetric guidance of transperineal 125I prostate implants using interventional magnetic resonance imaging. Int J Radiat Oncol Biol Phys. 2000 Jan 1; 46(1):207-14.
    View in: PubMed
  36. Kooy HM, Cormack RA, Mathiowitz G, Tempany C, D'Amico AV. A software system for interventional magnetic resonance image-guided prostate brachytherapy. Comput Aided Surg. 2000; 5(6):401-13.
    View in: PubMed
  37. Loeffler JS, Kooy HM, Tarbell NJ. The emergence of conformal radiotherapy: special implications for pediatric neuro-oncology. Int J Radiat Oncol Biol Phys. 1999 May 1; 44(2):237-8.
    View in: PubMed
  38. Zelefsky MJ, Crean D, Mageras GS, Lyass O, Happersett L, Ling CC, Leibel SA, Fuks Z, Bull S, Kooy HM, van Herk M, Kutcher GJ. Quantification and predictors of prostate position variability in 50 patients evaluated with multiple CT scans during conformal radiotherapy. Radiother Oncol. 1999 Feb; 50(2):225-34.
    View in: PubMed
  39. Mageras GS, Fuks Z, Leibel SA, Ling CC, Zelefsky MJ, Kooy HM, van Herk M, Kutcher GJ. Computerized design of target margins for treatment uncertainties in conformal radiotherapy. Int J Radiat Oncol Biol Phys. 1999 Jan 15; 43(2):437-45.
    View in: PubMed
  40. Shrieve DC, Alexander E, Black PM, Wen PY, Fine HA, Kooy HM, Loeffler JS. Treatment of patients with primary glioblastoma multiforme with standard postoperative radiotherapy and radiosurgical boost: prognostic factors and long-term outcome. J Neurosurg. 1999 Jan; 90(1):72-7.
    View in: PubMed
  41. D'Amico AV, Cormack R, Tempany CM, Kumar S, Topulos G, Kooy HM, Coleman CN. Real-time magnetic resonance image-guided interstitial brachytherapy in the treatment of select patients with clinically localized prostate cancer. Int J Radiat Oncol Biol Phys. 1998 Oct 1; 42(3):507-15.
    View in: PubMed
  42. Cormack RA, Kooy HM, Bellerive MR, Loeffler JS, Petersen RA, Tarbell NJ. A stereotactic radiation therapy device for retinoblastoma using a noncircular collimator and intensity filter. Med Phys. 1998 Aug; 25(8):1438-42.
    View in: PubMed
  43. Bellerive MR, Kooy HM, Loeffler JS. Linac radiosurgery at the Joint Center for Radiation Therapy. Med Dosim. 1998; 23(3):187-99.
    View in: PubMed
  44. Lu HM, Kooy HM, Leber ZH, Ledoux RJ. Optimized beam planning for linear accelerator-based stereotactic radiosurgery. Int J Radiat Oncol Biol Phys. 1997 Dec 1; 39(5):1183-9.
    View in: PubMed
  45. Hacker FL, Kooy HM, Bellerive MR, Killoran JH, Leber ZH, Shrieve DC, Tarbell NJ, Loeffler JS. Beam shaping for conformal fractionated stereotactic radiotherapy: a modeling study. Int J Radiat Oncol Biol Phys. 1997 Jul 15; 38(5):1113-21.
    View in: PubMed
  46. Shiu AS, Kooy HM, Ewton JR, Tung SS, Wong J, Antes K, Maor MH. Comparison of miniature multileaf collimation (MMLC) with circular collimation for stereotactic treatment. Int J Radiat Oncol Biol Phys. 1997 Feb 1; 37(3):679-88.
    View in: PubMed
  47. Killoran JH, Kooy HM, Gladstone DJ, Welte FJ, Beard CJ. A numerical simulation of organ motion and daily setup uncertainties: implications for radiation therapy. Int J Radiat Oncol Biol Phys. 1997 Jan 1; 37(1):213-21.
    View in: PubMed
  48. Varlotto JM, Shrieve DC, Alexander E, Kooy HM, Black PM, Loeffler JS. Fractionated stereotactic radiotherapy for the treatment of acoustic neuromas: preliminary results. Int J Radiat Oncol Biol Phys. 1996 Aug 1; 36(1):141-5.
    View in: PubMed
  49. Shrieve DC, Kooy HM, Tarbell NJ, Loeffler JS. Fractionated stereotactic radiotherapy. Important Adv Oncol. 1996; 205-24.
    View in: PubMed
  50. Alexander E, Kooy HM, van Herk M, Schwartz M, Barnes PD, Tarbell N, Mulkern RV, Holupka EJ, Loeffler JS. Magnetic resonance image-directed stereotactic neurosurgery: use of image fusion with computerized tomography to enhance spatial accuracy. J Neurosurg. 1995 Aug; 83(2):271-6.
    View in: PubMed
  51. Loeffler JS, Shrieve DC, Wen PY, Fine HA, Kooy HM, Addesa AE, Black PM, Alexander E. Radiosurgery for Intracranial Malignancies. Semin Radiat Oncol. 1995 Jul; 5(3):225-234.
    View in: PubMed
  52. Shrieve DC, Alexander E, Wen PY, Fine HA, Kooy HM, Black PM, Loeffler JS. Comparison of stereotactic radiosurgery and brachytherapy in the treatment of recurrent glioblastoma multiforme. Neurosurgery. 1995 Feb; 36(2):275-82; discussion 282-4.
    View in: PubMed
  53. Alexander E, Moriarty TM, Davis RB, Wen PY, Fine HA, Black PM, Kooy HM, Loeffler JS. Stereotactic radiosurgery for the definitive, noninvasive treatment of brain metastases. J Natl Cancer Inst. 1995 Jan 4; 87(1):34-40.
    View in: PubMed
  54. Dunbar SF, Tarbell NJ, Kooy HM, Alexander E, Black PM, Barnes PD, Goumnerova L, Scott RM, Pomeroy SL, La Vally B, et al. Stereotactic radiotherapy for pediatric and adult brain tumors: preliminary report. Int J Radiat Oncol Biol Phys. 1994 Oct 15; 30(3):531-9.
    View in: PubMed
  55. Kooy HM, Dunbar SF, Tarbell NJ, Mannarino E, Ferarro N, Shusterman S, Bellerive M, Finn L, McDonough CV, Loeffler JS. Adaptation and verification of the relocatable Gill-Thomas-Cosman frame in stereotactic radiotherapy. Int J Radiat Oncol Biol Phys. 1994 Oct 15; 30(3):685-91.
    View in: PubMed
  56. Bodis S, Alexander E, Kooy H, Loeffler JS. The prevention of radiosurgery-induced nausea and vomiting by ondansetron: evidence of a direct effect on the central nervous system chemoreceptor trigger zone. Surg Neurol. 1994 Sep; 42(3):249-52.
    View in: PubMed
  57. van Herk M, Kooy HM. Automatic three-dimensional correlation of CT-CT, CT-MRI, and CT-SPECT using chamfer matching. Med Phys. 1994 Jul; 21(7):1163-78.
    View in: PubMed
  58. Hughes-Davies L, Mannarino E, Alexander E, Kooy H, Loeffler JS. Technical modifications required to treat cervical chemodactomas with stereotactic radiosurgery. Surg Neurol. 1994 May; 41(5):418-20.
    View in: PubMed
  59. Kooy HM, van Herk M, Barnes PD, Alexander E, Dunbar SF, Tarbell NJ, Mulkern RV, Holupka EJ, Loeffler JS. Image fusion for stereotactic radiotherapy and radiosurgery treatment planning. Int J Radiat Oncol Biol Phys. 1994 Mar 30; 28(5):1229-34.
    View in: PubMed
  60. Schell MC, Kooy H. Stereotactic radiosurgery quality improvement: interdepartmental collaboration. Int J Radiat Oncol Biol Phys. 1994 Jan 15; 28(2):551-2.
    View in: PubMed
  61. Shrieve DC, Tarbell NJ, Alexander E, Kooy HM, Black PM, Dunbar S, Loeffler JS. Stereotactic radiotherapy: a technique for dose optimization and escalation for intracranial tumors. Acta Neurochir Suppl. 1994; 62:118-23.
    View in: PubMed
  62. Tishler RB, Loeffler JS, Lunsford LD, Duma C, Alexander E, Kooy HM, Flickinger JC. Tolerance of cranial nerves of the cavernous sinus to radiosurgery. Int J Radiat Oncol Biol Phys. 1993 Sep 30; 27(2):215-21.
    View in: PubMed
  63. Kooy HM, Nedzi LA, Alexander E, Loeffler JS, Ledoux RJ. Dose-volume histogram computations for small intracranial volumes. Med Phys. 1993 May-Jun; 20(3):755-60.
    View in: PubMed
  64. Nedzi LA, Kooy HM, Alexander E, Svensson GK, Loeffler JS. Dynamic field shaping for stereotactic radiosurgery: a modeling study. Int J Radiat Oncol Biol Phys. 1993 Apr 2; 25(5):859-69.
    View in: PubMed
  65. Loeffler JS, Alexander E, Shea WM, Wen PY, Fine HA, Kooy HM, Black PM. Radiosurgery as part of the initial management of patients with malignant gliomas. J Clin Oncol. 1992 Sep; 10(9):1379-85.
    View in: PubMed
  66. Holupka EJ, Kooy HM. A geometric algorithm for medical image correlations. Med Phys. 1992 Mar-Apr; 19(2):433-8.
    View in: PubMed
  67. Kooy HM, Nedzi LA, Loeffler JS, Alexander E, Cheng CW, Mannarino EG, Holupka EJ, Siddon RL. Treatment planning for stereotactic radiosurgery of intra-cranial lesions. Int J Radiat Oncol Biol Phys. 1991 Aug; 21(3):683-93.
    View in: PubMed
  68. Nedzi LA, Kooy H, Alexander E, Gelman RS, Loeffler JS. Variables associated with the development of complications from radiosurgery of intracranial tumors. Int J Radiat Oncol Biol Phys. 1991 Aug; 21(3):591-9.
    View in: PubMed
  69. Holupka EJ, Kooy HM. Spherical harmonic expansion of cranial surfaces. Med Phys. 1991 Jul-Aug; 18(4):765-8.
    View in: PubMed
  70. Loeffler JS, Alexander E, Wen PY, Shea WM, Coleman CN, Kooy HM, Fine HA, Nedzi LA, Silver B, Riese NE, et al. Results of stereotactic brachytherapy used in the initial management of patients with glioblastoma. J Natl Cancer Inst. 1990 Dec 19; 82(24):1918-21.
    View in: PubMed
  71. Boyages J, Recht A, Connolly JL, Schnitt SJ, Gelman R, Kooy H, Love S, Osteen RT, Cady B, Silver B, et al. Early breast cancer: predictors of breast recurrence for patients treated with conservative surgery and radiation therapy. Radiother Oncol. 1990 Sep; 19(1):29-41.
    View in: PubMed
  72. Loeffler JS, Kooy HM, Wen PY, Fine HA, Cheng CW, Mannarino EG, Tsai JS, Alexander E. The treatment of recurrent brain metastases with stereotactic radiosurgery. J Clin Oncol. 1990 Apr; 8(4):576-82.
    View in: PubMed
  73. Kooy HM, Barth NH. The verification of an inverse problem in radiation therapy. Int J Radiat Oncol Biol Phys. 1990 Feb; 18(2):433-9.
    View in: PubMed
  74. Kooy HM, Rashid H. A three-dimensional electron pencil-beam algorithm. Phys Med Biol. 1989 Feb; 34(2):229-43.
    View in: PubMed
  75. Kooy HM, Kijewski PK. Quadtrees as a representation for irregularly shaped fields in radiotherapy applications. Int J Radiat Oncol Biol Phys. 1988 Nov; 15(5):1251-6.
    View in: PubMed
  76. Kooy HM, Simpson LD, McFaul JA. Parallel-plate ionization chamber response in cobalt-60 irradiated transition zones. Med Phys. 1988 Mar-Apr; 15(2):199-203.
    View in: PubMed
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