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Oksana Berezovska, PH.D.

TitleAssociate Professor of Neurology
InstitutionMassachusetts General Hospital
DepartmentNeurology
AddressMassachusetts General Hospital
Alzheimer Research Unit, Rm. 2850
114 16th Street
Charlestown MA 02129
Phone617/726-7478
Fax617/724-1480

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wahlster L, Arimon M, Nasser-Ghodsi N, Post KL, Serrano-Pozo A, Uemura K, Berezovska O. Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer's disease. Acta Neuropathol. 2013 Feb; 125(2):187-99.
    View in: PubMed
  2. Li X, Uemura K, Hashimoto T, Nasser-Ghodsi N, Arimon M, Lill CM, Palazzolo I, Krainc D, Hyman BT, Berezovska O. Neuronal activity and secreted amyloid ß lead to altered amyloid ß precursor protein and presenilin 1 interactions. Neurobiol Dis. 2013 Feb; 50:127-34.
    View in: PubMed
  3. Guix FX, Wahle T, Vennekens K, Snellinx A, Chávez-Gutiérrez L, Ill-Raga G, Ramos-Fernandez E, Guardia-Laguarta C, Lleó A, Arimon M, Berezovska O, Muñoz FJ, Dotti CG, De Strooper B. Modification of ?-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease. EMBO Mol Med. 2012 Jul; 4(7):660-73.
    View in: PubMed
  4. Wu HY, Hudry E, Hashimoto T, Uemura K, Fan ZY, Berezovska O, Grosskreutz CL, Bacskai BJ, Hyman BT. Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-ß revealed by a novel fluorescence resonance energy transfer assay. J Neurosci. 2012 Apr 11; 32(15):5298-309.
    View in: PubMed
  5. Ohki Y, Higo T, Uemura K, Shimada N, Osawa S, Berezovska O, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T. Phenylpiperidine-type ?-secretase modulators target the transmembrane domain 1 of presenilin 1. EMBO J. 2011 Nov 30; 30(23):4815-24.
    View in: PubMed
  6. Asada-Utsugi M, Uemura K, Noda Y, Kuzuya A, Maesako M, Ando K, Kubota M, Watanabe K, Takahashi M, Kihara T, Shimohama S, Takahashi R, Berezovska O, Kinoshita A. N-cadherin enhances APP dimerization at the extracellular domain and modulates Aß production. J Neurochem. 2011 Oct; 119(2):354-63.
    View in: PubMed
  7. Fox JH, Connor T, Stiles M, Kama J, Lu Z, Dorsey K, Lieberman G, Liebermann G, Sapp E, Cherny RA, Banks M, Volitakis I, DiFiglia M, Berezovska O, Bush AI, Hersch SM. Cysteine oxidation within N-terminal mutant huntingtin promotes oligomerization and delays clearance of soluble protein. J Biol Chem. 2011 May 20; 286(20):18320-30.
    View in: PubMed
  8. Uemura K, Farner KC, Nasser-Ghodsi N, Jones P, Berezovska O. Reciprocal relationship between APP positioning relative to the membrane and PS1 conformation. Mol Neurodegener. 2011; 6(1):15.
    View in: PubMed
  9. Viswanathan J, Haapasalo A, Böttcher C, Miettinen R, Kurkinen KM, Lu A, Thomas A, Maynard CJ, Romano D, Hyman BT, Berezovska O, Bertram L, Soininen H, Dantuma NP, Tanzi RE, Hiltunen M. Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation. Traffic. 2011 Mar; 12(3):330-48.
    View in: PubMed
  10. Uemura K, Farner KC, Hashimoto T, Nasser-Ghodsi N, Wolfe MS, Koo EH, Hyman BT, Berezovska O. Substrate docking to ?-secretase allows access of ?-secretase modulators to an allosteric site. Nat Commun. 2010 Nov; 1(8):130.
    View in: PubMed
  11. Uemura K, Lill CM, Li X, Peters JA, Ivanov A, Fan Z, DeStrooper B, Bacskai BJ, Hyman BT, Berezovska O. Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio. PLoS One. 2009; 4(11):e7893.
    View in: PubMed
  12. Huttunen HJ, Peach C, Bhattacharyya R, Barren C, Pettingell W, Hutter-Paier B, Windisch M, Berezovska O, Kovacs DM. Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway. FASEB J. 2009 Nov; 23(11):3819-28.
    View in: PubMed
  13. Guardia-Laguarta C, Coma M, Pera M, Clarimón J, Sereno L, Agulló JM, Molina-Porcel L, Gallardo E, Deng A, Berezovska O, Hyman BT, Blesa R, Gómez-Isla T, Lleó A. Mild cholesterol depletion reduces amyloid-beta production by impairing APP trafficking to the cell surface. J Neurochem. 2009 Jul; 110(1):220-30.
    View in: PubMed
  14. Serneels L, Van Biervliet J, Craessaerts K, Dejaegere T, Horré K, Van Houtvin T, Esselmann H, Paul S, Schäfer MK, Berezovska O, Hyman BT, Sprangers B, Sciot R, Moons L, Jucker M, Yang Z, May PC, Karran E, Wiltfang J, D'Hooge R, De Strooper B. gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease. Science. 2009 May 1; 324(5927):639-42.
    View in: PubMed
  15. Herl L, Thomas AV, Lill CM, Banks M, Deng A, Jones PB, Spoelgen R, Hyman BT, Berezovska O. Mutations in amyloid precursor protein affect its interactions with presenilin/gamma-secretase. Mol Cell Neurosci. 2009 Jun; 41(2):166-74.
    View in: PubMed
  16. Uemura K, Lill CM, Banks M, Asada M, Aoyagi N, Ando K, Kubota M, Kihara T, Nishimoto T, Sugimoto H, Takahashi R, Hyman BT, Shimohama S, Berezovska O, Kinoshita A. N-cadherin-based adhesion enhances Abeta release and decreases Abeta42/40 ratio. J Neurochem. 2009 Jan; 108(2):350-60.
    View in: PubMed
  17. Tetzlaff JE, Putcha P, Outeiro TF, Ivanov A, Berezovska O, Hyman BT, McLean PJ. CHIP targets toxic alpha-Synuclein oligomers for degradation. J Biol Chem. 2008 Jun 27; 283(26):17962-8.
    View in: PubMed
  18. Thomas AV, Berezovska O, Hyman BT, von Arnim CA. Visualizing interaction of proteins relevant to Alzheimer's disease in intact cells. Methods. 2008 Apr; 44(4):299-303.
    View in: PubMed
  19. Jones PB, Rozkalne A, Meyer-Luehmann M, Spires-Jones TL, Makarova A, Kumar AT, Berezovska O, Bacskai BB, Hyman BT. Two postprocessing techniques for the elimination of background autofluorescence for fluorescence lifetime imaging microscopy. J Biomed Opt. 2008 Jan-Feb; 13(1):014008.
    View in: PubMed
  20. Nyborg AC, Herl L, Berezovska O, Thomas AV, Ladd TB, Jansen K, Hyman BT, Golde TE. Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells. Mol Neurodegener. 2006; 1:16.
    View in: PubMed
  21. Jones PB, Herl L, Berezovska O, Kumar AT, Bacskai BJ, Hyman BT. Time-domain fluorescent plate reader for cell based protein-protein interaction and protein conformation assays. J Biomed Opt. 2006 Sep-Oct; 11(5):054024.
    View in: PubMed
  22. Hiltunen M, Lu A, Thomas AV, Romano DM, Kim M, Jones PB, Xie Z, Kounnas MZ, Wagner SL, Berezovska O, Hyman BT, Tesco G, Bertram L, Tanzi RE. Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. J Biol Chem. 2006 Oct 27; 281(43):32240-53.
    View in: PubMed
  23. Thomas AV, Herl L, Spoelgen R, Hiltunen M, Jones PB, Tanzi RE, Hyman BT, Berezovska O. Interaction between presenilin 1 and ubiquilin 1 as detected by fluorescence lifetime imaging microscopy and a high-throughput fluorescent plate reader. J Biol Chem. 2006 Sep 8; 281(36):26400-7.
    View in: PubMed
  24. Herl L, Lleo A, Thomas AV, Nyborg AC, Jansen K, Golde TE, Hyman BT, Berezovska O. Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy. Biochem Biophys Res Commun. 2006 Feb 10; 340(2):668-74.
    View in: PubMed
  25. Tesco G, Ginestroni A, Hiltunen M, Kim M, Dolios G, Hyman BT, Wang R, Berezovska O, Tanzi RE. APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation. J Neurochem. 2005 Oct; 95(2):446-56.
    View in: PubMed
  26. Lleó A, Waldron E, von Arnim CA, Herl L, Tangredi MM, Peltan ID, Strickland DK, Koo EH, Hyman BT, Pietrzik CU, Berezovska O. Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase. J Biol Chem. 2005 Jul 22; 280(29):27303-9.
    View in: PubMed
  27. Berezovska O, Lleo A, Herl LD, Frosch MP, Stern EA, Bacskai BJ, Hyman BT. Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein. J Neurosci. 2005 Mar 16; 25(11):3009-17.
    View in: PubMed
  28. Lleó A, Berezovska O, Herl L, Raju S, Deng A, Bacskai BJ, Frosch MP, Irizarry M, Hyman BT. Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation. Nat Med. 2004 Oct; 10(10):1065-6.
    View in: PubMed
  29. Irizarry MC, Deng A, Lleo A, Berezovska O, Von Arnim CA, Martin-Rehrmann M, Manelli A, LaDu MJ, Hyman BT, Rebeck GW. Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein. J Neurochem. 2004 Sep; 90(5):1132-43.
    View in: PubMed
  30. Lleó A, Berezovska O, Growdon JH, Hyman BT. Clinical, pathological, and biochemical spectrum of Alzheimer disease associated with PS-1 mutations. Am J Geriatr Psychiatry. 2004 Mar-Apr; 12(2):146-56.
    View in: PubMed
  31. Ramdya P, Skoch J, Bacskai BJ, Hyman BT, Berezovska O. Activated Notch1 associates with a presenilin-1/gamma-secretase docking site. J Neurochem. 2003 Nov; 87(4):843-50.
    View in: PubMed
  32. Das C, Berezovska O, Diehl TS, Genet C, Buldyrev I, Tsai JY, Hyman BT, Wolfe MS. Designed helical peptides inhibit an intramembrane protease. J Am Chem Soc. 2003 Oct 1; 125(39):11794-5.
    View in: PubMed
  33. Lleó A, Berezovska O, Ramdya P, Fukumoto H, Raju S, Shah T, Hyman BT. Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression. J Biol Chem. 2003 Nov 28; 278(48):47370-5.
    View in: PubMed
  34. Berezovska O, Bacskai BJ, Hyman BT. Monitoring proteins in intact cells. Sci Aging Knowledge Environ. 2003 Jun 11; 2003(23):PE14.
    View in: PubMed
  35. Berezovska O, Ramdya P, Skoch J, Wolfe MS, Bacskai BJ, Hyman BT. Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging. J Neurosci. 2003 Jun 1; 23(11):4560-6.
    View in: PubMed
  36. Micchelli CA, Esler WP, Kimberly WT, Jack C, Berezovska O, Kornilova A, Hyman BT, Perrimon N, Wolfe MS. Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila. FASEB J. 2003 Jan; 17(1):79-81.
    View in: PubMed
  37. Kinoshita A, Whelan CM, Smith CJ, Berezovska O, Hyman BT. Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus. J Neurochem. 2002 Aug; 82(4):839-47.
    View in: PubMed
  38. Kinoshita A, Whelan CM, Berezovska O, Hyman BT. The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells. J Biol Chem. 2002 Aug 9; 277(32):28530-6.
    View in: PubMed
  39. Zaidi NF, Berezovska O, Choi EK, Miller JS, Chan H, Lilliehook C, Hyman BT, Buxbaum JD, Wasco W. Biochemical and immunocytochemical characterization of calsenilin in mouse brain. Neuroscience. 2002; 114(1):247-63.
    View in: PubMed
  40. Puglielli L, Konopka G, Pack-Chung E, Ingano LA, Berezovska O, Hyman BT, Chang TY, Tanzi RE, Kovacs DM. Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. Nat Cell Biol. 2001 Oct; 3(10):905-12.
    View in: PubMed
  41. Maysinger D, Berezovska O, Savic R, Soo PL, Eisenberg A. Block copolymers modify the internalization of micelle-incorporated probes into neural cells. Biochim Biophys Acta. 2001 Jun 20; 1539(3):205-17.
    View in: PubMed
  42. Berezovska O, Jack C, Deng A, Gastineau N, Rebeck GW, Hyman BT. Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage. J Biol Chem. 2001 Aug 10; 276(32):30018-23.
    View in: PubMed
  43. Jack C, Berezovska O, Wolfe MS, Hyman BT. Effect of PS1 deficiency and an APP gamma-secretase inhibitor on Notch1 signaling in primary mammalian neurons. Brain Res Mol Brain Res. 2001 Mar 5; 87(2):166-74.
    View in: PubMed
  44. Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Kimberly WT, Weinmaster G, Selkoe DJ, Hyman BT. Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling. J Neurochem. 2000 Aug; 75(2):583-93.
    View in: PubMed
  45. Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Weinmaster G, Selkoe DJ, Hyman BT. Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity. Ann N Y Acad Sci. 2000; 920:223-6.
    View in: PubMed
  46. Wang Y, Berezovska O, Fedoroff S. Expression of colony stimulating factor-1 receptor (CSF-1R) by CNS neurons in mice. J Neurosci Res. 1999 Sep 1; 57(5):616-32.
    View in: PubMed
  47. Berezovska O, Frosch M, McLean P, Knowles R, Koo E, Kang D, Shen J, Lu FM, Lux SE, Tonegawa S, Hyman BT. The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons. Brain Res Mol Brain Res. 1999 Jun 8; 69(2):273-80.
    View in: PubMed
  48. Berezovska O, McLean P, Knowles R, Frosh M, Lu FM, Lux SE, Hyman BT. Notch1 inhibits neurite outgrowth in postmitotic primary neurons. Neuroscience. 1999; 93(2):433-9.
    View in: PubMed
  49. Berezovska O, Xia MQ, Hyman BT. Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease. J Neuropathol Exp Neurol. 1998 Aug; 57(8):738-45.
    View in: PubMed
  50. Xia MQ, Berezovska O, Kim TW, Xia WM, Liao A, Tanzi RE, Selkoe D, Hyman BT. Lack of specific association of presenilin 1 (PS-1) protein with plaques and tangles in Alzheimer's disease. J Neurol Sci. 1998 Jun 11; 158(1):15-23.
    View in: PubMed
  51. Rebeck GW, Alonzo NC, Berezovska O, Harr SD, Knowles RB, Growdon JH, Hyman BT, Mendez AJ. Structure and functions of human cerebrospinal fluid lipoproteins from individuals of different APOE genotypes. Exp Neurol. 1998 Jan; 149(1):175-82.
    View in: PubMed
  52. Berezovska O, Xia MQ, Page K, Wasco W, Tanzi RE, Hyman BT. Developmental regulation of presenilin mRNA expression parallels notch expression. J Neuropathol Exp Neurol. 1997 Jan; 56(1):40-4.
    View in: PubMed
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