Mathias Lichterfeld, M.D.
|Title||Assistant Professor of Medicine|
|Institution||Massachusetts General Hospital|
|Address||Massachusetts General Hospital|
55 Fruit St
Boston MA 02114
Available: 05/30/13, Expires: 06/01/14
This opportunity would be funded by a year-long fellowship from the Doris Duke Charitable Foundation. Please contact Mathias Lichterfeld, M.D., for more information.
My lab is interested in developing strategies to target cells with latent HIV-1 infection. Currently available antiretroviral therapy can effectively suppress active HIV-1 replication, but HIV-1 can persist in a latent form where it is unaffected by currently available antiretroviral pharmaceuticals. Once treatment is stopped, these latently infected cells can rapidly re-initiate high-level viral replication. My lab is interested in identifying CD4 T cells populations that represent a preferred niche for latent HIV-1 infection, and in developing novel pharmaceutical and/or immunological interventions that can reduce the number of latently infected CD4 T cells. We are also involved in clinical trials in which novel interventions for targeting latently infected cells are investigated. These efforts may ultimately lead to new therapeutic options that can induce a long-term drug-free remission or "cure" of HIV-1 infection.
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