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Yongqing Li, Ph.D., M.D.

TitleAssistant Professor of Surgery
InstitutionMassachusetts General Hospital
DepartmentSurgery
AddressMassachusetts General Hospital
Suite 810
165 Cambridge St
Boston MA 02114
Phone617/643-2714
Fax617/643-2927

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Liu Z, Li Y, Chong W, Deperalta DK, Duan X, Liu B, Halaweish I, Zhou P, Alam HB. Creating a prosurvival phenotype through a histone deacetylase inhibitor in a lethal two-hit model. Shock. 2014 Feb; 41(2):104-8.
    View in: PubMed
  2. Hwabejire JO, Imam AM, Jin G, Liu B, Li Y, Sillesen M, Jepsen CH, Lu J, Demoya MA, Alam HB. Differential effects of fresh frozen plasma and normal saline on secondary brain damage in a large animal model of polytrauma, hemorrhage and traumatic brain injury. J Trauma Acute Care Surg. 2013 Dec; 75(6):968-75.
    View in: PubMed
  3. Hwabejire JO, Lu J, Liu B, Li Y, Halaweish I, Alam HB. Valproic acid for the treatment of hemorrhagic shock: a dose-optimization study. J Surg Res. 2014 Jan; 186(1):363-70.
    View in: PubMed
  4. Hwabejire JO, Jin G, Imam AM, Duggan M, Sillesen M, Deperalta D, Jepsen CH, Lu J, Li Y, Demoya MA, Alam HB. Pharmacologic modulation of cerebral metabolic derangement and excitotoxicity in a porcine model of traumatic brain injury and hemorrhagic shock. Surgery. 2013 Aug; 154(2):234-43.
    View in: PubMed
  5. Zhao T, Li Y, Liu B, Liu Z, Chong W, Duan X, Deperalta DK, Velmahos GC, Alam HB. Novel pharmacologic treatment attenuates septic shock and improves long-term survival. Surgery. 2013 Aug; 154(2):206-13.
    View in: PubMed
  6. Liu Z, Li Y, Liu B, Deperalta DK, Zhao T, Chong W, Duan X, Zhou P, Velmahos GC, Alam HB. Synergistic effects of hypertonic saline and valproic acid in a lethal rat two-hit model. J Trauma Acute Care Surg. 2013 Apr; 74(4):991-7; discussion 997-8.
    View in: PubMed
  7. Kasotakis G, Duggan M, Li Y, O'Dowd D, Baldwin K, de Moya MA, King DR, Alam HB, Velmahos G. Optimal pressure of abdominal gas insufflation for bleeding control in a severe swine splenic injury model. J Surg Res. 2013 Oct; 184(2):931-6.
    View in: PubMed
  8. Li Y, Liu B, Gu X, Kochanek AR, Fukudome EY, Liu Z, Zhao T, Chong W, Zhao Y, Zhang D, Libermann TA, Alam HB. Creating a "pro-survival" phenotype through epigenetic modulation. Surgery. 2012 Sep; 152(3):455-64.
    View in: PubMed
  9. Chong W, Li Y, Liu B, Zhao T, Fukudome EY, Liu Z, Smith WM, Velmahos GC, Demoya MA, Alam HB. Histone deacetylase inhibitor suberoylanilide hydroxamic acid attenuates Toll-like receptor 4 signaling in lipopolysaccharide-stimulated mouse macrophages. J Surg Res. 2012 Dec; 178(2):851-9.
    View in: PubMed
  10. Fukudome EY, Li Y, Kochanek AR, Lu J, Smith EJ, Liu B, Kim K, Velmahos GC, deMoya MA, Alam HB. Pharmacologic resuscitation decreases circulating cytokine-induced neutrophil chemoattractant-1 levels and attenuates hemorrhage-induced acute lung injury. Surgery. 2012 Aug; 152(2):254-61.
    View in: PubMed
  11. Alam HB, Li Y. International Patent: Citrullinated Histone H3 (Cit H3) in Septic Shock. 2012.
  12. Chong W, Li Y, Liu B, Liu Z, Zhao T, Wonsey DR, Chen C, Velmahos GC, deMoya MA, King DR, Kung AL, Alam HB. Anti-inflammatory properties of histone deacetylase inhibitors: a mechanistic study. J Trauma Acute Care Surg. 2012 Feb; 72(2):347-53; discussion 353-4.
    View in: PubMed
  13. Li Y, Alam HB. Creating a pro-survival and anti-inflammatory phenotype by modulation of acetylation in models of hemorrhagic and septic shock. Adv Exp Med Biol. 2012; 710:107-33.
    View in: PubMed
  14. Jin G, Bausch D, Knightly T, Liu Z, Li Y, Liu B, Lu J, Chong W, Velmahos GC, Alam HB. Histone deacetylase inhibitors enhance endothelial cell sprouting angiogenesis in vitro. Surgery. 2011 Sep; 150(3):429-35.
    View in: PubMed
  15. Li Y, Liu B, Fukudome EY, Lu J, Chong W, Jin G, Liu Z, Velmahos GC, Demoya M, King DR, Alam HB. Identification of citrullinated histone H3 as a potential serum protein biomarker in a lethal model of lipopolysaccharide-induced shock. Surgery. 2011 Sep; 150(3):442-51.
    View in: PubMed
  16. Kim K, Li Y, Jin G, Chong W, Liu B, Lu J, Lee K, Demoya M, Velmahos GC, Alam HB. Effect of valproic acid on acute lung injury in a rodent model of intestinal ischemia reperfusion. Resuscitation. 2012 Feb; 83(2):243-8.
    View in: PubMed
  17. Kochanek AR, Fukudome EY, Li Y, Smith EJ, Liu B, Velmahos GC, deMoya M, King D, Alam HB. Histone deacetylase inhibitor treatment attenuates MAP kinase pathway activation and pulmonary inflammation following hemorrhagic shock in a rodent model. J Surg Res. 2012 Jul; 176(1):185-94.
    View in: PubMed
  18. Li Y, Alam HB. Modulation of acetylation: creating a pro-survival and anti-inflammatory phenotype in lethal hemorrhagic and septic shock. J Biomed Biotechnol. 2011; 2011:523481.
    View in: PubMed
  19. Leu SW, Shi L, Xu C, Zhao Y, Liu B, Li Y, Shiedlin A, Xiang C, Shen H, Quinn DA, Hales CA, Zhao H. TLR4 through IFN-ß promotes low molecular mass hyaluronan-induced neutrophil apoptosis. J Immunol. 2011 Jan 1; 186(1):556-62.
    View in: PubMed
  20. Zacharias N, Sailhamer EA, Li Y, Liu B, Butt MU, Shuja F, Velmahos GC, de Moya M, Alam HB. Histone deacetylase inhibitors prevent apoptosis following lethal hemorrhagic shock in rodent kidney cells. Resuscitation. 2011 Jan; 82(1):105-9.
    View in: PubMed
  21. Li Y, Liu B, Fukudome EY, Kochanek AR, Finkelstein RA, Chong W, Jin G, Lu J, deMoya MA, Velmahos GC, Alam HB. Surviving lethal septic shock without fluid resuscitation in a rodent model. Surgery. 2010 Aug; 148(2):246-54.
    View in: PubMed
  22. Finkelstein RA, Li Y, Liu B, Shuja F, Fukudome E, Velmahos GC, deMoya M, Alam HB. Treatment with histone deacetylase inhibitor attenuates MAP kinase mediated liver injury in a lethal model of septic shock. J Surg Res. 2010 Sep; 163(1):146-54.
    View in: PubMed
  23. Fukudome EY, Kochanek AR, Li Y, Smith EJ, Liu B, Kheirbek T, Lu J, Kim K, Hamwi K, Velmahos GC, Alam HB. Pharmacologic resuscitation promotes survival and attenuates hemorrhage-induced activation of extracellular signal-regulated kinase 1/2. J Surg Res. 2010 Sep; 163(1):118-26.
    View in: PubMed
  24. Alam HB, Hashmi S, Finkelstein RA, Frankelstein RA, Shuja F, Fukudome EY, Li Y, Liu B, Demoya M, Velmahos GC. Alterations in gene expression after induction of profound hypothermia for the treatment of lethal hemorrhage. J Trauma. 2010 May; 68(5):1084-98.
    View in: PubMed
  25. Alam HB, Li Y. US Patent: Biomarkers of hemorrhagic shock. 2010.
  26. Sailhamer EA, Li Y, Smith EJ, Liu B, Shuja F, Soupir CP, DeMoya MA, Velmahos GC, Alam HB. Hypoxic "second hit" in leukocytes from trauma patients: Modulation of the immune response by histone deacetylase inhibition. Cytokine. 2010 Mar; 49(3):303-11.
    View in: PubMed
  27. Li Y, Liu B, Zhao H, Sailhamer EA, Fukudome EY, Zhang X, Kheirbek T, Finkelstein RA, Velmahos GC, deMoya M, Hales CA, Alam HB. Protective effect of suberoylanilide hydroxamic acid against LPS-induced septic shock in rodents. Shock. 2009 Nov; 32(5):517-23.
    View in: PubMed
  28. Alam HB, Shuja F, Butt MU, Duggan M, Li Y, Zacharias N, Fukudome EY, Liu B, Demoya M, Velmahos GC. Surviving blood loss without blood transfusion in a swine poly-trauma model. Surgery. 2009 Aug; 146(2):325-33.
    View in: PubMed
  29. Shuja F, Tabbara M, Li Y, Liu B, Butt MU, Velmahos GC, DeMoya M, Alam HB. Profound hypothermia decreases cardiac apoptosis through Akt survival pathway. J Am Coll Surg. 2009 Jul; 209(1):89-99.
    View in: PubMed
  30. Li Y, Liu B, Dillon ST, Fukudome EY, Kheirbek T, Sailhamer EA, Velmahos G, deMoya M, Libermann TA, Alam HB. Identification of a novel potential biomarker in a model of hemorrhagic shock and valproic acid treatment. J Surg Res. 2010 Mar; 159(1):474-81.
    View in: PubMed
  31. Butt MU, Sailhamer EA, Li Y, Liu B, Shuja F, Velmahos GC, DeMoya M, King DR, Alam HB. Pharmacologic resuscitation: cell protective mechanisms of histone deacetylase inhibition in lethal hemorrhagic shock. J Surg Res. 2009 Oct; 156(2):290-6.
    View in: PubMed
  32. Li Y, Liu B, Sailhamer EA, Yuan Z, Shults C, Velmahos GC, deMoya M, Shuja F, Butt MU, Alam HB. Cell protective mechanism of valproic acid in lethal hemorrhagic shock. Surgery. 2008 Aug; 144(2):217-24.
    View in: PubMed
  33. Sailhamer EA, Li Y, Smith EJ, Shuja F, Shults C, Liu B, Soupir C, deMoya M, Velmahos G, Alam HB. Acetylation: a novel method for modulation of the immune response following trauma/hemorrhage and inflammatory second hit in animals and humans. Surgery. 2008 Aug; 144(2):204-16.
    View in: PubMed
  34. Alam HB, Duggan M, Li Y, Spaniolas K, Liu B, Tabbara M, Demoya M, Sailhamer EA, Shults C, Velmahos GC. Putting life on hold-for how long? Profound hypothermic cardiopulmonary bypass in a Swine model of complex vascular injuries. J Trauma. 2008 Apr; 64(4):912-22.
    View in: PubMed
  35. Li Y, Yuan Z, Liu B, Sailhamer EA, Shults C, Velmahos GC, Demoya M, Alam HB. Prevention of hypoxia-induced neuronal apoptosis through histone deacetylase inhibition. J Trauma. 2008 Apr; 64(4):863-70; discussion 870-1.
    View in: PubMed
  36. Velmahos GC, Spaniolas K, Tabbara M, Duggan M, Li Y, De Moya M, Alam HB. Abdominal insufflation decreases blood loss without worsening the inflammatory response: implications for prehospital control of internal bleeding. Am Surg. 2008 Apr; 74(4):297-301.
    View in: PubMed
  37. Shults C, Sailhamer EA, Li Y, Liu B, Tabbara M, Butt MU, Shuja F, Demoya M, Velmahos G, Alam HB. Surviving blood loss without fluid resuscitation. J Trauma. 2008 Mar; 64(3):629-38; discussion 638-40.
    View in: PubMed
  38. Sailhamer E, Li Y, Zhao H, Hales CA, Shuja F, Butt MU, Velmahos GC, deMoya MA, Alam HB. . Histone deacetylase inhibition: a novel treatment for lethal septic shock. J Am Coll Surg. 2008; 207(Suppl):S36.
  39. Alam HB, Shults C, Ahuja N, Ayuste EC, Chen H, Koustova E, Sailhamer EA, Li Y, Liu B, de Moya M, Velmahos GC. Impact of resuscitation strategies on the acetylation status of cardiac histones in a swine model of hemorrhage. Resuscitation. 2008 Feb; 76(2):299-310.
    View in: PubMed
  40. Lin T, Chen H, Koustova E, Sailhamer EA, Li Y, Shults C, Liu B, Rhee P, Kirkpatrick J, Alam HB. Histone deacetylase as therapeutic target in a rodent model of hemorrhagic shock: effect of different resuscitation strategies on lung and liver. Surgery. 2007 Jun; 141(6):784-94.
    View in: PubMed
  41. Alam HB, Chen Z, Li Y, Velmahos G, DeMoya M, Keller CE, Toruno K, Mehrani T, Rhee P, Spaniolas K. Profound hypothermia is superior to ultraprofound hypothermia in improving survival in a swine model of lethal injuries. Surgery. 2006 Aug; 140(2):307-14.
    View in: PubMed
  42. Chen H, Alam HB, Querol RI, Rhee P, Li Y, Koustova E. Identification of expression patterns associated with hemorrhage and resuscitation: integrated approach to data analysis. J Trauma. 2006 Apr; 60(4):701-23; discussion 723-4.
    View in: PubMed
  43. Ren J, Agata N, Chen D, Li Y, Yu WH, Huang L, Raina D, Chen W, Kharbanda S, Kufe D. Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents. Cancer Cell. 2004 Feb; 5(2):163-75.
    View in: PubMed
  44. Huang L, Ren J, Chen D, Li Y, Kharbanda S, Kufe D. MUC1 cytoplasmic domain coactivates Wnt target gene transcription and confers transformation. Cancer Biol Ther. 2003 Nov-Dec; 2(6):702-6.
    View in: PubMed
  45. Li Y, Liu D, Chen D, Kharbanda S, Kufe D. Human DF3/MUC1 carcinoma-associated protein functions as an oncogene. Oncogene. 2003 Sep 4; 22(38):6107-10.
    View in: PubMed
  46. Li Y, Yu WH, Ren J, Chen W, Huang L, Kharbanda S, Loda M, Kufe D. Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein. Mol Cancer Res. 2003 Aug; 1(10):765-75.
    View in: PubMed
  47. Yin L, Li Y, Ren J, Kuwahara H, Kufe D. Human MUC1 carcinoma antigen regulates intracellular oxidant levels and the apoptotic response to oxidative stress. J Biol Chem. 2003 Sep 12; 278(37):35458-64.
    View in: PubMed
  48. Li Y, Chen W, Ren J, Yu WH, Li Q, Yoshida K, Kufe D. DF3/MUC1 signaling in multiple myeloma cells is regulated by interleukin-7. Cancer Biol Ther. 2003 Mar-Apr; 2(2):187-93.
    View in: PubMed
  49. Ren J, Datta R, Shioya H, Li Y, Oki E, Biedermann V, Bharti A, Kufe D. p73beta is regulated by protein kinase Cdelta catalytic fragment generated in the apoptotic response to DNA damage. J Biol Chem. 2002 Sep 13; 277(37):33758-65.
    View in: PubMed
  50. Ren J, Li Y, Kufe D. Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signaling. J Biol Chem. 2002 May 17; 277(20):17616-22.
    View in: PubMed
  51. Li Y, Ren J, Yu W, Li Q, Kuwahara H, Yin L, Carraway KL, Kufe D. The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin. J Biol Chem. 2001 Sep 21; 276(38):35239-42.
    View in: PubMed
  52. Li Y, Kufe D. The Human DF3/MUC1 carcinoma-associated antigen signals nuclear localization of the catenin p120(ctn). Biochem Biophys Res Commun. 2001 Feb 23; 281(2):440-3.
    View in: PubMed
  53. Li Y, Kuwahara H, Ren J, Wen G, Kufe D. The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-catenin. J Biol Chem. 2001 Mar 2; 276(9):6061-4.
    View in: PubMed
  54. Chen D, Koido S, Li Y, Gendler S, Gong J. T cell suppression as a mechanism for tolerance to MUC1 antigen in MUC1 transgenic mice. Breast Cancer Res Treat. 2000 Mar; 60(2):107-15.
    View in: PubMed
  55. Li Y, Hua F, Carraway KL, Carraway CA. The p185(neu)-containing glycoprotein complex of a microfilament-associated signal transduction particle. Purification, reconstitution, and molecular associations with p58(gag) and actin. J Biol Chem. 1999 Sep 3; 274(36):25651-8.
    View in: PubMed
  56. Huang J, Zhang BT, Li Y, Mayer B, Carraway KL, Carraway CA. c-Src association with and phosphorylation of p58gag, a membrane- and microfilament-associated retroviral Gag-like protein in a xenotransplantable rat mammary tumor. Oncogene. 1999 Jul 15; 18(28):4099-107.
    View in: PubMed
  57. Li Y, Bharti A, Chen D, Gong J, Kufe D. Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin. Mol Cell Biol. 1998 Dec; 18(12):7216-24.
    View in: PubMed
  58. Li Y, Rinehart CA. Regulation of keratinocyte growth factor expression in human endometrium: implications for hormonal carcinogenesis. Mol Carcinog. 1998 Dec; 23(4):217-25.
    View in: PubMed
  59. Gong J, Chen D, Kashiwaba M, Li Y, Chen L, Takeuchi H, Qu H, Rowse GJ, Gendler SJ, Kufe D. Reversal of tolerance to human MUC1 antigen in MUC1 transgenic mice immunized with fusions of dendritic and carcinoma cells. Proc Natl Acad Sci U S A. 1998 May 26; 95(11):6279-83.
    View in: PubMed
  60. Yamamoto M, Bharti A, Li Y, Kufe D. Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesion. J Biol Chem. 1997 May 9; 272(19):12492-4.
    View in: PubMed
  61. Juang SH, Huang J, Li Y, Salas PJ, Fregien N, Carraway CA, Carraway KL. Molecular cloning and sequencing of a 58-kDa membrane- and microfilament-associated protein from ascites tumor cell microvilli with sequence similarities to retroviral Gag proteins. J Biol Chem. 1994 May 27; 269(21):15067-75.
    View in: PubMed
  62. Carraway CA, Carvajal ME, Li Y, Carraway KL. Association of p185neu with microfilaments via a large glycoprotein complex in mammary carcinoma microvilli. Evidence for a microfilament-associated signal transduction particle. J Biol Chem. 1993 Mar 15; 268(8):5582-7.
    View in: PubMed
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