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A. Aria Tzika, PH.D.

TitleAssistant Professor of Surgery
InstitutionMassachusetts General Hospital
DepartmentSurgery
AddressShriners' Burn Institute
Room #261
51 Blossom St
Boston MA 02114
Phone617/371-4871
Fax617/720-3544

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Metsis V, Huang H, Andronesi OC, Makedon F, Tzika A. Heterogeneous data fusion for brain tumor classification. Oncol Rep. 2012 Oct; 28(4):1413-6.
    View in: PubMed
  2. Astrakas LG, Naqvi SH, Kateb B, Tzika AA. Functional MRI using robotic MRI compatible devices for monitoring rehabilitation from chronic stroke in the molecular medicine era (Review). Int J Mol Med. 2012 Jun; 29(6):963-73.
    View in: PubMed
  3. Andronesi OC, Kim GS, Gerstner E, Batchelor T, Tzika AA, Fantin VR, Vander Heiden MG, Sorensen AG. Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy. Sci Transl Med. 2012 Jan 11; 4(116):116ra4.
    View in: PubMed
  4. Astrakas L, Blekas KD, Constantinou C, Andronesi OC, Mindrinos MN, Likas AC, Rahme LG, Black PM, Marcus KJ, Tzika AA. Combining magnetic resonance spectroscopy and molecular genomics offers better accuracy in brain tumor typing and prediction of survival than either methodology alone. Int J Oncol. 2011 Apr; 38(4):1113-27.
    View in: PubMed
  5. Constantinou C, Fontes de Oliveira CC, Mintzopoulos D, Busquets S, He J, Kesarwani M, Mindrinos M, Rahme LG, Argilés JM, Tzika AA. Nuclear magnetic resonance in conjunction with functional genomics suggests mitochondrial dysfunction in a murine model of cancer cachexia. Int J Mol Med. 2011 Jan; 27(1):15-24.
    View in: PubMed
  6. Andronesi OC, Mintzopoulos D, Righi V, Psychogios N, Kesarwani M, He J, Yasuhara S, Dai G, Rahme LG, Tzika AA. Combined off-resonance imaging and T2 relaxation in the rotating frame for positive contrast MR imaging of infection in a murine burn model. J Magn Reson Imaging. 2010 Nov; 32(5):1172-83.
    View in: PubMed
  7. Righi V, Apidianakis Y, Mintzopoulos D, Astrakas L, Rahme LG, Tzika AA. In vivo high-resolution magic angle spinning magnetic resonance spectroscopy of Drosophila melanogaster at 14.1 T shows trauma in aging and in innate immune-deficiency is linked to reduced insulin signaling. Int J Mol Med. 2010 Aug; 26(2):175-84.
    View in: PubMed
  8. Righi V, Apidianakis Y, Rahme LG, Tzika AA. Magnetic resonance spectroscopy of live Drosophila melanogaster using magic angle spinning. J Vis Exp. 2010; (38).
    View in: PubMed
  9. Righi V, Andronesi OC, Mintzopoulos D, Black PM, Tzika AA. High-resolution magic angle spinning magnetic resonance spectroscopy detects glycine as a biomarker in brain tumors. Int J Oncol. 2010 Feb; 36(2):301-6.
    View in: PubMed
  10. Righi V, Andronesi O, Mintzopoulos D, Tzika AA. Molecular characterization and quantification using state of the art solid-state adiabatic TOBSY NMR in burn trauma. Int J Mol Med. 2009 Dec; 24(6):749-57.
    View in: PubMed
  11. Tzika AA, Mintzopoulos D, Mindrinos M, Zhang J, Rahme LG, Tompkins RG. Microarray analysis suggests that burn injury results in mitochondrial dysfunction in human skeletal muscle. Int J Mol Med. 2009 Sep; 24(3):387-92.
    View in: PubMed
  12. Mintzopoulos D, Astrakas LG, Khanicheh A, Konstas AA, Singhal A, Moskowitz MA, Rosen BR, Tzika AA. Connectivity alterations assessed by combining fMRI and MR-compatible hand robots in chronic stroke. Neuroimage. 2009 Aug; 47 Suppl 2:T90-7.
    View in: PubMed
  13. Andronesi OC, Blekas KD, Mintzopoulos D, Astrakas L, Black PM, Tzika AA. Molecular classification of brain tumor biopsies using solid-state magic angle spinning proton magnetic resonance spectroscopy and robust classifiers. Int J Oncol. 2008 Nov; 33(5):1017-25.
    View in: PubMed
  14. Mintzopoulos D, Khanicheh A, Konstas AA, Astrakas LG, Singhal AB, Moskowitz MA, Rosen BR, Tzika AA. Functional MRI of Rehabilitation in Chronic Stroke Patients Using Novel MR-Compatible Hand Robots. Open Neuroimag J. 2008; 2:94-101.
    View in: PubMed
  15. Tzika AA, Astrakas LG, Cao H, Mintzopoulos D, Zhang Q, Padfield K, Yu H, Mindrinos MN, Rahme LG, Tompkins RG. Murine intramyocellular lipids quantified by NMR act as metabolic biomarkers in burn trauma. Int J Mol Med. 2008 Jun; 21(6):825-32.
    View in: PubMed
  16. Andronesi OC, Mintzopoulos D, Struppe J, Black PM, Tzika AA. Solid-state NMR adiabatic TOBSY sequences provide enhanced sensitivity for multidimensional high-resolution magic-angle-spinning 1H MR spectroscopy. J Magn Reson. 2008 Aug; 193(2):251-8.
    View in: PubMed
  17. Tzika AA. Proton magnetic resonance spectroscopic imaging as a cancer biomarker for pediatric brain tumors (Review). Int J Oncol. 2008 Mar; 32(3):517-26.
    View in: PubMed
  18. Tzika AA, Mintzopoulos D, Padfield K, Wilhelmy J, Mindrinos MN, Yu H, Cao H, Zhang Q, Astrakas LG, Zhang J, Yu YM, Rahme LG, Tompkins RG. Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1beta in distal skeletal muscle following burn. Int J Mol Med. 2008 Feb; 21(2):201-8.
    View in: PubMed
  19. Khanicheh A, Mintzopoulos D, Weinberg B, Tzika AA, Mavroidis C. MR_CHIROD v.2: magnetic resonance compatible smart hand rehabilitation device for brain imaging. IEEE Trans Neural Syst Rehabil Eng. 2008 Feb; 16(1):91-8.
    View in: PubMed
  20. Lesic B, Lépine F, Déziel E, Zhang J, Zhang Q, Padfield K, Castonguay MH, Milot S, Stachel S, Tzika AA, Tompkins RG, Rahme LG. Inhibitors of pathogen intercellular signals as selective anti-infective compounds. PLoS Pathog. 2007 Sep 14; 3(9):1229-39.
    View in: PubMed
  21. Tzika AA, Astrakas L, Cao H, Mintzopoulos D, Andronesi OC, Mindrinos M, Zhang J, Rahme LG, Blekas KD, Likas AC, Galatsanos NP, Carroll RS, Black PM. Combination of high-resolution magic angle spinning proton magnetic resonance spectroscopy and microscale genomics to type brain tumor biopsies. Int J Mol Med. 2007 Aug; 20(2):199-208.
    View in: PubMed
  22. Marcus KJ, Astrakas LG, Zurakowski D, Zarifi MK, Mintzopoulos D, Poussaint TY, Anthony DC, De Girolami U, Black PM, Tarbell NJ, Tzika AA. Predicting survival of children with CNS tumors using proton magnetic resonance spectroscopic imaging biomarkers. Int J Oncol. 2007 Mar; 30(3):651-7.
    View in: PubMed
  23. Zhang Q, Cao H, Astrakas LG, Mintzopoulos D, Mindrinos MN, Schulz J, Tompkins RG, Rahme LG, Tzika AA. Uncoupling protein 3 expression and intramyocellular lipid accumulation by NMR following local burn trauma. Int J Mol Med. 2006 Dec; 18(6):1223-9.
    View in: PubMed
  24. Khanicheh A, Muto A, Triantafyllou C, Weinberg B, Astrakas L, Tzika A, Mavroidis C. fMRI-compatible rehabilitation hand device. J Neuroeng Rehabil. 2006; 3:24.
    View in: PubMed
  25. Padfield KE, Zhang Q, Gopalan S, Tzika AA, Mindrinos MN, Tompkins RG, Rahme LG. Local and distant burn injury alter immuno-inflammatory gene expression in skeletal muscle. J Trauma. 2006 Aug; 61(2):280-92.
    View in: PubMed
  26. Astrakas L, Ye S, Zarifi M, Makedon F, Tzika AA. The clinical perspective of large scale projects: a case study of multiparametric MR imaging of pediatric brain tumors. Oncol Rep. 2006; 15 Spec no.:1065-9.
    View in: PubMed
  27. Astrakas LG, Goljer I, Yasuhara S, Padfield KE, Zhang Q, Gopalan S, Mindrinos MN, Dai G, Yu YM, Martyn JA, Tompkins RG, Rahme LG, Tzika AA. Proton NMR spectroscopy shows lipids accumulate in skeletal muscle in response to burn trauma-induced apoptosis. FASEB J. 2005 Sep; 19(11):1431-40.
    View in: PubMed
  28. Padfield KE, Astrakas LG, Zhang Q, Gopalan S, Dai G, Mindrinos MN, Tompkins RG, Rahme LG, Tzika AA. Burn injury causes mitochondrial dysfunction in skeletal muscle. Proc Natl Acad Sci U S A. 2005 Apr 12; 102(15):5368-73.
    View in: PubMed
  29. Astrakas LG, Zurakowski D, Tzika AA, Zarifi MK, Anthony DC, De Girolami U, Tarbell NJ, Black PM. Noninvasive magnetic resonance spectroscopic imaging biomarkers to predict the clinical grade of pediatric brain tumors. Clin Cancer Res. 2004 Dec 15; 10(24):8220-8.
    View in: PubMed
  30. Tzika AA, Astrakas LG, Zarifi MK, Zurakowski D, Poussaint TY, Goumnerova L, Tarbell NJ, Black PM. Spectroscopic and perfusion magnetic resonance imaging predictors of progression in pediatric brain tumors. Cancer. 2004 Mar 15; 100(6):1246-56.
    View in: PubMed
  31. Caruso PA, Poussaint TY, Tzika AA, Zurakowski D, Astrakas LG, Elias ER, Bay C, Irons MB. MRI and 1H MRS findings in Smith-Lemli-Opitz syndrome. Neuroradiology. 2004 Jan; 46(1):3-14.
    View in: PubMed
  32. Zarifi MK, Astrakas LG, Poussaint TY, Plessis Ad Ad, Zurakowski D, Tzika AA. Prediction of adverse outcome with cerebral lactate level and apparent diffusion coefficient in infants with perinatal asphyxia. Radiology. 2002 Dec; 225(3):859-70.
    View in: PubMed
  33. Tzika AA, Astrakas LG, Zarifi MK, Petridou N, Young-Poussaint T, Goumnerova L, Zurakowski D, Anthony DC, Black PM. Multiparametric MR assessment of pediatric brain tumors. Neuroradiology. 2003 Jan; 45(1):1-10.
    View in: PubMed
  34. Tzika AA, Cheng LL, Goumnerova L, Madsen JR, Zurakowski D, Astrakas LG, Zarifi MK, Scott RM, Anthony DC, Gonzalez RG, Black PM. Biochemical characterization of pediatric brain tumors by using in vivo and ex vivo magnetic resonance spectroscopy. J Neurosurg. 2002 Jun; 96(6):1023-31.
    View in: PubMed
  35. Astrakas LG, Teicher M, Tzika AA. Activation of attention networks using frequency analysis of a simple auditory-motor paradigm. Neuroimage. 2002 Apr; 15(4):961-9.
    View in: PubMed
  36. Tzika AA, Zarifi MK, Goumnerova L, Astrakas LG, Zurakowski D, Young-Poussaint T, Anthony DC, Scott RM, Black PM. Neuroimaging in pediatric brain tumors: Gd-DTPA-enhanced, hemodynamic, and diffusion MR imaging compared with MR spectroscopic imaging. AJNR Am J Neuroradiol. 2002 Feb; 23(2):322-33.
    View in: PubMed
  37. Soul JS, Robertson RL, Tzika AA, du Plessis AJ, Volpe JJ. Time course of changes in diffusion-weighted magnetic resonance imaging in a case of neonatal encephalopathy with defined onset and duration of hypoxic-ischemic insult. Pediatrics. 2001 Nov; 108(5):1211-4.
    View in: PubMed
  38. Zarifi MK, Tzika AA, Astrakas LG, Poussaint TY, Anthony DC, Darras BT. Magnetic resonance spectroscopy and magnetic resonance imaging findings in Krabbe's disease. J Child Neurol. 2001 Jul; 16(7):522-6.
    View in: PubMed
  39. Tzika AA, Zurakowski D, Poussaint TY, Goumnerova L, Astrakas LG, Barnes PD, Anthony DC, Billett AL, Tarbell NJ, Scott RM, Black PM. Proton magnetic spectroscopic imaging of the child's brain: the response of tumors to treatment. Neuroradiology. 2001 Feb; 43(2):169-77.
    View in: PubMed
  40. Cheng LL, Anthony DC, Comite AR, Black PM, Tzika AA, Gonzalez RG. Quantification of microheterogeneity in glioblastoma multiforme with ex vivo high-resolution magic-angle spinning (HRMAS) proton magnetic resonance spectroscopy. Neuro Oncol. 2000 Apr; 2(2):87-95.
    View in: PubMed
  41. Tzika AA, Robertson RL, Barnes PD, Vajapeyam S, Burrows PE, Treves ST, Scott RM. Childhood moyamoya disease: hemodynamic MRI. Pediatr Radiol. 1997 Sep; 27(9):727-35.
    View in: PubMed
  42. Tzika AA, Vajapeyam S, Barnes PD. Multivoxel proton MR spectroscopy and hemodynamic MR imaging of childhood brain tumors: preliminary observations. AJNR Am J Neuroradiol. 1997 Feb; 18(2):203-18.
    View in: PubMed
  43. Tzika AA, Vigneron DB, Dunn RS, Nelson SJ, Ball WS. Intracranial tumors in children: small single-voxel proton MR spectroscopy using short- and long-echo sequences. Neuroradiology. 1996 Apr; 38(3):254-63.
    View in: PubMed
  44. Mulkern RV, Meng J, Oshio K, Tzika AA. Line scan imaging of brain metabolites with CPMG sequences at 1.5 tesla. J Magn Reson Imaging. 1996 Mar-Apr; 6(2):399-405.
    View in: PubMed
  45. Barnes PD, O'Tuama L, Tzika A. Investigating the pediatric central nervous system. Curr Opin Pediatr. 1993 Dec; 5(6):643-52.
    View in: PubMed
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