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Keywords
Last Name
Institution

Vadim Gladyshev, Ph.D.

TitleProfessor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressHarvard Institutes of Medicine
BWH/Genetics - Rm 435
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/525-5122
Fax617/525-5147

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Moustafa ME, Carlson BA, Anver MR, Bobe G, Zhong N, Ward JM, Perella CM, Hoffmann VJ, Rogers K, Combs GF, Schweizer U, Merlino G, Gladyshev VN, Hatfield DL. Selenium and Selenoprotein Deficiencies Induce Widespread Pyogranuloma Formation in Mice, while High Levels of Dietary Selenium Decrease Liver Tumor Size Driven by TGFa. PLoS One. 2013; 8(2):e57389.
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  2. Hondal RJ, Marino SM, Gladyshev VN. Selenocysteine in thiol/disulfide-like exchange reactions. Antioxid Redox Signal. 2013 May 1; 18(13):1675-89.
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  3. Tsuji PA, Carlson BA, Naranjo-Suarez S, Yoo MH, Xu XM, Fomenko DE, Gladyshev VN, Hatfield DL, Davis CD. Knockout of the 15 kDa Selenoprotein Protects against Chemically-Induced Aberrant Crypt Formation in Mice. PLoS One. 2012; 7(12):e50574.
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  4. Liang X, Kaya A, Zhang Y, Le DT, Hua D, Gladyshev VN. Characterization of methionine oxidation and methionine sulfoxide reduction using methionine-rich cysteine-free proteins. BMC Biochem. 2012; 13:21.
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  5. Gerashchenko MV, Lobanov AV, Gladyshev VN. Genome-wide ribosome profiling reveals complex translational regulation in response to oxidative stress. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17394-9.
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  6. Tarrago L, Gladyshev VN. Recharging Oxidative Protein Repair: Catalysis by Methionine Sulfoxide Reductases towards Their Amino Acid, Protein, and Model Substrates. Biochemistry (Mosc). 2012 Oct; 77(10):1097-107.
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  7. Gladyshev VN. On the cause of aging and control of lifespan: Heterogeneity leads to inevitable damage accumulation, causing aging; Control of damage composition and rate of accumulation define lifespan. Bioessays. 2012 Nov; 34(11):925-9.
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  8. Tobe R, Yoo MH, Fradejas N, Carlson BA, Calvo S, Gladyshev VN, Hatfield DL. Thioredoxin reductase 1 deficiency enhances selenite toxicity in cancer cells via a thioredoxin-independent mechanism. Biochem J. 2012 Aug 1; 445(3):423-30.
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  9. Carlson BA, Yoo MH, Tobe R, Mueller C, Naranjo-Suarez S, Hoffmann VJ, Gladyshev VN, Hatfield DL. Thioredoxin reductase 1 protects against chemically induced hepatocarcinogenesis via control of cellular redox homeostasis. Carcinogenesis. 2012 Sep; 33(9):1806-13.
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  10. Tarrago L, Kaya A, Weerapana E, Marino SM, Gladyshev VN. Methionine sulfoxide reductases preferentially reduce unfolded oxidized proteins and protect cells from oxidative protein unfolding. J Biol Chem. 2012 Jul 13; 287(29):24448-59.
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  11. Anisimov VN, Bartke A, Barzilai N, Batin MA, Blagosklonny MV, Brown-Borg H, Budovskaya Y, Campisi J, Friguet B, Fraifeld V, Franceschi C, Gems D, Gladyshev V, Gorbunova V, Gudkov AV, Kennedy B, Konovalenko M, Kraemer B, Moskalev A, Petropoulos I, Pasyukova E, Rattan S, Rogina B, Seluanov A, Shaposhnikov M, Shmookler Reis R, Tavernarakis N, Vijg J, Yashin A, Zimniak P. The second international conference "genetics of aging and longevity". Aging (Albany NY). 2012 May; 4(5):305-17.
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  12. Ross F, Hernández P, Porcal W, López GV, Cerecetto H, González M, Basika T, Carmona C, Fló M, Maggioli G, Bonilla M, Gladyshev VN, Boiani M, Salinas G. Identification of thioredoxin glutathione reductase inhibitors that kill cestode and trematode parasites. PLoS One. 2012; 7(4):e35033.
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  13. Mariotti M, Ridge PG, Zhang Y, Lobanov AV, Pringle TH, Guigo R, Hatfield DL, Gladyshev VN. Composition and evolution of the vertebrate and Mammalian selenoproteomes. PLoS One. 2012; 7(3):e33066.
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  14. Kasaikina MV, Hatfield DL, Gladyshev VN. Understanding selenoprotein function and regulation through the use of rodent models. Biochim Biophys Acta. 2012 Sep; 1823(9):1633-42.
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  15. Vinogradov DV, Tsoi OV, Zaika AV, Lobanov AV, Turanov AA, Gladyshev VN, Gel'fand MS. [Draft macronuclear genome of a ciliate Euplotes crassus]. Mol Biol (Mosk). 2012 Mar-Apr; 46(2):361-6.
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  16. Naranjo-Suarez S, Carlson BA, Tsuji PA, Yoo MH, Gladyshev VN, Hatfield DL. HIF-independent regulation of thioredoxin reductase 1 contributes to the high levels of reactive oxygen species induced by hypoxia. PLoS One. 2012; 7(2):e30470.
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  17. Marino SM, Gladyshev VN. Analysis and functional prediction of reactive cysteine residues. J Biol Chem. 2012 Feb 10; 287(7):4419-25.
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  18. Gladyshev VN, Zhang G, Wang J. The naked mole rat genome: understanding aging through genome analysis. Aging (Albany NY). 2011 Dec; 3(12):1124.
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  19. Fomenko DE, Gladyshev VN. Comparative genomics of thiol oxidoreductases reveals widespread and essential functions of thiol-based redox control of cellular processes. Antioxid Redox Signal. 2012 Feb 1; 16(3):193-201.
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  20. Malinouski M, Kehr S, Finney L, Vogt S, Carlson BA, Seravalli J, Jin R, Handy DE, Park TJ, Loscalzo J, Hatfield DL, Gladyshev VN. High-resolution imaging of selenium in kidneys: a localized selenium pool associated with glutathione peroxidase 3. Antioxid Redox Signal. 2012 Feb 1; 16(3):185-92.
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  21. Uluisik I, Kaya A, Fomenko DE, Karakaya HC, Carlson BA, Gladyshev VN, Koc A. Boron stress activates the general amino acid control mechanism and inhibits protein synthesis. PLoS One. 2011; 6(11):e27772.
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  22. Shchedrina VA, Everley RA, Zhang Y, Gygi SP, Hatfield DL, Gladyshev VN. Selenoprotein K binds multiprotein complexes and is involved in the regulation of endoplasmic reticulum homeostasis. J Biol Chem. 2011 Dec 16; 286(50):42937-48.
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  23. Kim EB, Fang X, Fushan AA, Huang Z, Lobanov AV, Han L, Marino SM, Sun X, Turanov AA, Yang P, Yim SH, Zhao X, Kasaikina MV, Stoletzki N, Peng C, Polak P, Xiong Z, Kiezun A, Zhu Y, Chen Y, Kryukov GV, Zhang Q, Peshkin L, Yang L, Bronson RT, Buffenstein R, Wang B, Han C, Li Q, Chen L, Zhao W, Sunyaev SR, Park TJ, Zhang G, Wang J, Gladyshev VN. Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature. 2011 Nov 10; 479(7372):223-7.
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  24. Carlson BA, Yoo MH, Conrad M, Gladyshev VN, Hatfield DL, Park JM. Protein kinase-regulated expression and immune function of thioredoxin reductase 1 in mouse macrophages. Mol Immunol. 2011 Oct; 49(1-2):311-6.
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  25. Shumilina E, Soldà A, Gerashchenko M, Gladyshev VN, Dikiy A. ¹H, ¹³C, and ¹5N NMR resonance assignments of reduced full length and shortened forms of the Grx domain of Mus musculus TGR. Biomol NMR Assign. 2012 Apr; 6(1):103-7.
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  26. Aachmann FL, Kwak GH, Del Conte R, Kim HY, Gladyshev VN, Dikiy A. Structural and biochemical analysis of mammalian methionine sulfoxide reductase B2. Proteins. 2011 Nov; 79(11):3123-31.
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  27. Lee BC, Fomenko DE, Gladyshev VN. Selective reduction of methylsulfinyl-containing compounds by mammalian MsrA suggests a strategy for improved drug efficacy. ACS Chem Biol. 2011 Oct 21; 6(10):1029-35.
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  28. Yim SH, Kim YJ, Oh SY, Fujii J, Zhang Y, Gladyshev VN, Rhee SG. Identification and characterization of alternatively transcribed form of peroxiredoxin IV gene that is specifically expressed in spermatids of postpubertal mouse testis. J Biol Chem. 2011 Nov 11; 286(45):39002-12.
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  29. Kasaikina MV, Fomenko DE, Labunskyy VM, Lachke SA, Qiu W, Moncaster JA, Zhang J, Wojnarowicz MW, Natarajan SK, Malinouski M, Schweizer U, Tsuji PA, Carlson BA, Maas RL, Lou MF, Goldstein LE, Hatfield DL, Gladyshev VN. Roles of the 15-kDa selenoprotein (Sep15) in redox homeostasis and cataract development revealed by the analysis of Sep 15 knockout mice. J Biol Chem. 2011 Sep 23; 286(38):33203-12.
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  30. Wu C, Parrott AM, Fu C, Liu T, Marino SM, Gladyshev VN, Jain MR, Baykal AT, Li Q, Oka S, Sadoshima J, Beuve A, Simmons WJ, Li H. Thioredoxin 1-mediated post-translational modifications: reduction, transnitrosylation, denitrosylation, and related proteomics methodologies. Antioxid Redox Signal. 2011 Nov 1; 15(9):2565-604.
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  31. Shchedrina VA, Kabil H, Vorbruggen G, Lee BC, Turanov AA, Hirosawa-Takamori M, Kim HY, Harshman LG, Hatfield DL, Gladyshev VN. Analyses of fruit flies that do not express selenoproteins or express the mouse selenoprotein, methionine sulfoxide reductase B1, reveal a role of selenoproteins in stress resistance. J Biol Chem. 2011 Aug 26; 286(34):29449-61.
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  32. Kim JY, Carlson BA, Xu XM, Zeng Y, Chen S, Gladyshev VN, Lee BJ, Hatfield DL. Inhibition of selenocysteine tRNA[Ser]Sec aminoacylation provides evidence that aminoacylation is required for regulatory methylation of this tRNA. Biochem Biophys Res Commun. 2011 Jun 17; 409(4):814-9.
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  33. Zhang Y, Gladyshev VN. Comparative genomics of trace element dependence in biology. J Biol Chem. 2011 Jul 8; 286(27):23623-9.
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  34. Marino SM, Gladyshev VN. Redox biology: computational approaches to the investigation of functional cysteine residues. Antioxid Redox Signal. 2011 Jul 1; 15(1):135-46.
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  35. Kasaikina MV, Kravtsova MA, Lee BC, Seravalli J, Peterson DA, Walter J, Legge R, Benson AK, Hatfield DL, Gladyshev VN. Dietary selenium affects host selenoproteome expression by influencing the gut microbiota. FASEB J. 2011 Jul; 25(7):2492-9.
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  36. Labunskyy VM, Lee BC, Handy DE, Loscalzo J, Hatfield DL, Gladyshev VN. Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice. Antioxid Redox Signal. 2011 Jun 15; 14(12):2327-36.
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  37. Turanov AA, Xu XM, Carlson BA, Yoo MH, Gladyshev VN, Hatfield DL. Biosynthesis of selenocysteine, the 21st amino Acid in the genetic code, and a novel pathway for cysteine biosynthesis. Adv Nutr. 2011 Mar; 2(2):122-8.
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  38. Lee BC, Lobanov AV, Marino SM, Kaya A, Seravalli J, Hatfield DL, Gladyshev VN. A 4-selenocysteine, 2-selenocysteine insertion sequence (SECIS) element methionine sulfoxide reductase from Metridium senile reveals a non-catalytic function of selenocysteines. J Biol Chem. 2011 May 27; 286(21):18747-55.
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  39. Kasaikina MV, Lobanov AV, Malinouski MY, Lee BC, Seravalli J, Fomenko DE, Turanov AA, Finney L, Vogt S, Park TJ, Miller RA, Hatfield DL, Gladyshev VN. Reduced utilization of selenium by naked mole rats due to a specific defect in GPx1 expression. J Biol Chem. 2011 May 13; 286(19):17005-14.
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  40. Gobler CJ, Berry DL, Dyhrman ST, Wilhelm SW, Salamov A, Lobanov AV, Zhang Y, Collier JL, Wurch LL, Kustka AB, Dill BD, Shah M, VerBerkmoes NC, Kuo A, Terry A, Pangilinan J, Lindquist EA, Lucas S, Paulsen IT, Hattenrath-Lehmann TK, Talmage SC, Walker EA, Koch F, Burson AM, Marcoval MA, Tang YZ, Lecleir GR, Coyne KJ, Berg GM, Bertrand EM, Saito MA, Gladyshev VN, Grigoriev IV. Niche of harmful alga Aureococcus anophagefferens revealed through ecogenomics. Proc Natl Acad Sci U S A. 2011 Mar 15; 108(11):4352-7.
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  41. Marino SM, Gladyshev VN. Proteomics: mapping reactive cysteines. Nat Chem Biol. 2011 Feb; 7(2):72-3.
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  42. Fomenko DE, Koc A, Agisheva N, Jacobsen M, Kaya A, Malinouski M, Rutherford JC, Siu KL, Jin DY, Winge DR, Gladyshev VN. Thiol peroxidases mediate specific genome-wide regulation of gene expression in response to hydrogen peroxide. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2729-34.
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  43. Malinouski M, Zhou Y, Belousov VV, Hatfield DL, Gladyshev VN. Hydrogen peroxide probes directed to different cellular compartments. PLoS One. 2011; 6(1):e14564.
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  44. Suzuki Y, St Onge RP, Mani R, King OD, Heilbut A, Labunskyy VM, Chen W, Pham L, Zhang LV, Tong AH, Nislow C, Giaever G, Gladyshev VN, Vidal M, Schow P, Lehár J, Roth FP. Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection. Nat Methods. 2011 Feb; 8(2):159-64.
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  45. Kim MJ, Lee BC, Jeong J, Lee KJ, Hwang KY, Gladyshev VN, Kim HY. Tandem use of selenocysteine: adaptation of a selenoprotein glutaredoxin for reduction of selenoprotein methionine sulfoxide reductase. Mol Microbiol. 2011 Mar; 79(5):1194-203.
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  46. Ahmed ZM, Yousaf R, Lee BC, Khan SN, Lee S, Lee K, Husnain T, Rehman AU, Bonneux S, Ansar M, Ahmad W, Leal SM, Gladyshev VN, Belyantseva IA, Van Camp G, Riazuddin S, Friedman TB, Riazuddin S. Functional null mutations of MSRB3 encoding methionine sulfoxide reductase are associated with human deafness DFNB74. Am J Hum Genet. 2011 Jan 7; 88(1):19-29.
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  47. Xu XM, Turanov AA, Carlson BA, Yoo MH, Everley RA, Nandakumar R, Sorokina I, Gygi SP, Gladyshev VN, Hatfield DL. Targeted insertion of cysteine by decoding UGA codons with mammalian selenocysteine machinery. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21430-4.
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  48. Lee BC, Gladyshev VN. The biological significance of methionine sulfoxide stereochemistry. Free Radic Biol Med. 2011 Jan 15; 50(2):221-7.
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  49. Bonilla M, Denicola A, Marino SM, Gladyshev VN, Salinas G. Linked thioredoxin-glutathione systems in platyhelminth parasites: alternative pathways for glutathione reduction and deglutathionylation. J Biol Chem. 2011 Feb 18; 286(7):4959-67.
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  50. Marino SM, Gladyshev VN. Cysteine function governs its conservation and degeneration and restricts its utilization on protein surfaces. J Mol Biol. 2010 Dec 17; 404(5):902-16.
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  51. Hacioglu E, Esmer I, Fomenko DE, Gladyshev VN, Koc A. The roles of thiol oxidoreductases in yeast replicative aging. Mech Ageing Dev. 2010 Nov-Dec; 131(11-12):692-9.
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  52. Kaya A, Koc A, Lee BC, Fomenko DE, Rederstorff M, Krol A, Lescure A, Gladyshev VN. Compartmentalization and regulation of mitochondrial function by methionine sulfoxide reductases in yeast. Biochemistry. 2010 Oct 5; 49(39):8618-25.
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  53. Marino SM, Li Y, Fomenko DE, Agisheva N, Cerny RL, Gladyshev VN. Characterization of surface-exposed reactive cysteine residues in Saccharomyces cerevisiae. Biochemistry. 2010 Sep 7; 49(35):7709-21.
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  54. Turanov AA, Kehr S, Marino SM, Yoo MH, Carlson BA, Hatfield DL, Gladyshev VN. Mammalian thioredoxin reductase 1: roles in redox homoeostasis and characterization of cellular targets. Biochem J. 2010 Sep 1; 430(2):285-93.
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  55. Sengupta A, Lichti UF, Carlson BA, Ryscavage AO, Gladyshev VN, Yuspa SH, Hatfield DL. Selenoproteins are essential for proper keratinocyte function and skin development. PLoS One. 2010; 5(8):e12249.
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  56. Lobanov AV, Turanov AA, Hatfield DL, Gladyshev VN. Dual functions of codons in the genetic code. Crit Rev Biochem Mol Biol. 2010 Aug; 45(4):257-65.
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  57. Liang X, Fomenko DE, Hua D, Kaya A, Gladyshev VN. Diversity of protein and mRNA forms of mammalian methionine sulfoxide reductase B1 due to intronization and protein processing. PLoS One. 2010; 5(7):e11497.
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  58. Aachmann FL, Sal LS, Kim HY, Marino SM, Gladyshev VN, Dikiy A. Insights into function, catalytic mechanism, and fold evolution of selenoprotein methionine sulfoxide reductase B1 through structural analysis. J Biol Chem. 2010 Oct 22; 285(43):33315-23.
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  59. Carlson BA, Yoo MH, Shrimali RK, Irons R, Gladyshev VN, Hatfield DL, Park JM. Role of selenium-containing proteins in T-cell and macrophage function. Proc Nutr Soc. 2010 Aug; 69(3):300-10.
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  60. Turanov AA, Hatfield DL, Gladyshev VN. Characterization of protein targets of mammalian thioredoxin reductases. Methods Enzymol. 2010; 474:245-54.
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  61. Yoo MH, Carlson BA, Tsuji P, Irons R, Gladyshev VN, Hatfield DL. Alteration of thioredoxin reductase 1 levels in elucidating cancer etiology. Methods Enzymol. 2010; 474:255-75.
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  62. Irons R, Tsuji PA, Carlson BA, Ouyang P, Yoo MH, Xu XM, Hatfield DL, Gladyshev VN, Davis CD. Deficiency in the 15-kDa selenoprotein inhibits tumorigenicity and metastasis of colon cancer cells. Cancer Prev Res (Phila). 2010 May; 3(5):630-9.
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  63. Shchedrina VA, Zhang Y, Labunskyy VM, Hatfield DL, Gladyshev VN. Structure-function relations, physiological roles, and evolution of mammalian ER-resident selenoproteins. Antioxid Redox Signal. 2010 Apr 1; 12(7):839-49.
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  64. Yoo MH, Gu X, Xu XM, Kim JY, Carlson BA, Patterson AD, Cai H, Gladyshev VN, Hatfield DL. Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer's disease. Antioxid Redox Signal. 2010 Apr 1; 12(7):819-27.
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  65. Novoselov SV, Kim HY, Hua D, Lee BC, Astle CM, Harrison DE, Friguet B, Moustafa ME, Carlson BA, Hatfield DL, Gladyshev VN. Regulation of selenoproteins and methionine sulfoxide reductases A and B1 by age, calorie restriction, and dietary selenium in mice. Antioxid Redox Signal. 2010 Apr 1; 12(7):829-38.
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  66. Zhang Y, Gladyshev VN. dbTEU: a protein database of trace element utilization. Bioinformatics. 2010 Mar 1; 26(5):700-2.
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  67. Gerashchenko MV, Su D, Gladyshev VN. CUG start codon generates thioredoxin/glutathione reductase isoforms in mouse testes. J Biol Chem. 2010 Feb 12; 285(7):4595-602.
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  68. Sengupta A, Carlson BA, Labunskyy VM, Gladyshev VN, Hatfield DL. Selenoprotein T deficiency alters cell adhesion and elevates selenoprotein W expression in murine fibroblast cells. Biochem Cell Biol. 2009 Dec; 87(6):953-61.
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  69. Zhang Y, Gladyshev VN. General trends in trace element utilization revealed by comparative genomic analyses of Co, Cu, Mo, Ni, and Se. J Biol Chem. 2010 Jan 29; 285(5):3393-405.
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  70. Carlson BA, Yoo MH, Sano Y, Sengupta A, Kim JY, Irons R, Gladyshev VN, Hatfield DL, Park JM. Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expression. BMC Immunol. 2009; 10:57.
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  71. Marino SM, Gladyshev VN. Structural analysis of cysteine S-nitrosylation: a modified acid-based motif and the emerging role of trans-nitrosylation. J Mol Biol. 2010 Jan 29; 395(4):844-59.
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  72. Zhang Y, Gladyshev VN. Comparative genomics of trace elements: emerging dynamic view of trace element utilization and function. Chem Rev. 2009 Oct; 109(10):4828-61.
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  73. Jin BY, Sartoretto JL, Gladyshev VN, Michel T. Endothelial nitric oxide synthase negatively regulates hydrogen peroxide-stimulated AMP-activated protein kinase in endothelial cells. Proc Natl Acad Sci U S A. 2009 Oct 13; 106(41):17343-8.
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  74. Bekaert M, Firth AE, Zhang Y, Gladyshev VN, Atkins JF, Baranov PV. Recode-2: new design, new search tools, and many more genes. Nucleic Acids Res. 2010 Jan; 38(Database issue):D69-74.
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  75. Carlson BA, Yoo MH, Tsuji PA, Gladyshev VN, Hatfield DL. Mouse models targeting selenocysteine tRNA expression for elucidating the role of selenoproteins in health and development. Molecules. 2009; 14(9):3509-27.
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  76. Labunskyy VM, Yoo MH, Hatfield DL, Gladyshev VN. Sep15, a thioredoxin-like selenoprotein, is involved in the unfolded protein response and differentially regulated by adaptive and acute ER stresses. Biochemistry. 2009 Sep 8; 48(35):8458-65.
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  77. Xu XM, Yoo MH, Carlson BA, Gladyshev VN, Hatfield DL. Simultaneous knockdown of the expression of two genes using multiple shRNAs and subsequent knock-in of their expression. Nat Protoc. 2009; 4(9):1338-48.
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  78. Lobanov AV, Hatfield DL, Gladyshev VN. Eukaryotic selenoproteins and selenoproteomes. Biochim Biophys Acta. 2009 Nov; 1790(11):1424-8.
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  79. Marino SM, Gladyshev VN. A structure-based approach for detection of thiol oxidoreductases and their catalytic redox-active cysteine residues. PLoS Comput Biol. 2009 May; 5(5):e1000383.
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  80. Lee BC, Dikiy A, Kim HY, Gladyshev VN. Functions and evolution of selenoprotein methionine sulfoxide reductases. Biochim Biophys Acta. 2009 Nov; 1790(11):1471-7.
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  81. Kaya A, Karakaya HC, Fomenko DE, Gladyshev VN, Koc A. Identification of a novel system for boron transport: Atr1 is a main boron exporter in yeast. Mol Cell Biol. 2009 Jul; 29(13):3665-74.
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  82. Shchedrina VA, Vorbrüggen G, Lee BC, Kim HY, Kabil H, Harshman LG, Gladyshev VN. Overexpression of methionine-R-sulfoxide reductases has no influence on fruit fly aging. Mech Ageing Dev. 2009 Jul; 130(7):429-43.
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  83. Kehr S, Malinouski M, Finney L, Vogt S, Labunskyy VM, Kasaikina MV, Carlson BA, Zhou Y, Hatfield DL, Gladyshev VN. X-ray fluorescence microscopy reveals the role of selenium in spermatogenesis. J Mol Biol. 2009 Jun 26; 389(5):808-18.
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  84. Hatfield DL, Yoo MH, Carlson BA, Gladyshev VN. Selenoproteins that function in cancer prevention and promotion. Biochim Biophys Acta. 2009 Nov; 1790(11):1541-5.
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  85. Kim HY, Zhang Y, Lee BC, Kim JR, Gladyshev VN. The selenoproteome of Clostridium sp. OhILAs: characterization of anaerobic bacterial selenoprotein methionine sulfoxide reductase A. Proteins. 2009 Mar; 74(4):1008-17.
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  86. Carlson BA, Schweizer U, Perella C, Shrimali RK, Feigenbaum L, Shen L, Speransky S, Floss T, Jeong SJ, Watts J, Hoffmann V, Combs GF, Gladyshev VN, Hatfield DL. The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice. Biochem J. 2009 Feb 15; 418(1):61-71.
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  87. Zhang Y, Rodionov DA, Gelfand MS, Gladyshev VN. Comparative genomic analyses of nickel, cobalt and vitamin B12 utilization. BMC Genomics. 2009; 10:78.
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  88. Hatfield DL, Gladyshev VN. The Outcome of Selenium and Vitamin E Cancer Prevention Trial (SELECT) reveals the need for better understanding of selenium biology. Mol Interv. 2009 Feb; 9(1):18-21.
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  89. Turanov AA, Lobanov AV, Fomenko DE, Morrison HG, Sogin ML, Klobutcher LA, Hatfield DL, Gladyshev VN. Genetic code supports targeted insertion of two amino acids by one codon. Science. 2009 Jan 9; 323(5911):259-61.
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  90. Le DT, Lee BC, Marino SM, Zhang Y, Fomenko DE, Kaya A, Hacioglu E, Kwak GH, Koc A, Kim HY, Gladyshev VN. Functional analysis of free methionine-R-sulfoxide reductase from Saccharomyces cerevisiae. J Biol Chem. 2009 Feb 13; 284(7):4354-64.
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  91. Papp LV, Wang J, Kennedy D, Boucher D, Zhang Y, Gladyshev VN, Singh RN, Khanna KK. Functional characterization of alternatively spliced human SECISBP2 transcript variants. Nucleic Acids Res. 2008 Dec; 36(22):7192-206.
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  92. Fomenko DE, Novoselov SV, Natarajan SK, Lee BC, Koc A, Carlson BA, Lee TH, Kim HY, Hatfield DL, Gladyshev VN. MsrB1 (methionine-R-sulfoxide reductase 1) knock-out mice: roles of MsrB1 in redox regulation and identification of a novel selenoprotein form. J Biol Chem. 2009 Feb 27; 284(9):5986-93.
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  93. Breivik AS, Aachmann FL, Sal LS, Kim HY, Del Conte R, del Conte R, Gladyshev VN, Dikiy A. 1H, 15N and 13C NMR assignments of mouse methionine sulfoxide reductase B2. Biomol NMR Assign. 2008 Dec; 2(2):199-201.
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  94. Hirosawa-Takamori M, Ossipov D, Novoselov SV, Turanov AA, Zhang Y, Gladyshev VN, Krol A, Vorbrüggen G, Jäckle H. A novel stem loop control element-dependent UGA read-through system without translational selenocysteine incorporation in Drosophila. FASEB J. 2009 Jan; 23(1):107-13.
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  95. Lee BC, Le DT, Gladyshev VN. Mammals reduce methionine-S-sulfoxide with MsrA and are unable to reduce methionine-R-sulfoxide, and this function can be restored with a yeast reductase. J Biol Chem. 2008 Oct 17; 283(42):28361-9.
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  96. Fomenko DE, Marino SM, Gladyshev VN. Functional diversity of cysteine residues in proteins and unique features of catalytic redox-active cysteines in thiol oxidoreductases. Mol Cells. 2008 Sep 30; 26(3):228-35.
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  97. Sengupta A, Carlson BA, Weaver JA, Novoselov SV, Fomenko DE, Gladyshev VN, Hatfield DL. A functional link between housekeeping selenoproteins and phase II enzymes. Biochem J. 2008 Jul 1; 413(1):151-61.
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  98. Le DT, Liang X, Fomenko DE, Raza AS, Chong CK, Carlson BA, Hatfield DL, Gladyshev VN. Analysis of methionine/selenomethionine oxidation and methionine sulfoxide reductase function using methionine-rich proteins and antibodies against their oxidized forms. Biochemistry. 2008 Jun 24; 47(25):6685-94.
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  99. Zhang Y, Gladyshev VN. Trends in selenium utilization in marine microbial world revealed through the analysis of the global ocean sampling (GOS) project. PLoS Genet. 2008 Jun; 4(6):e1000095.
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  100. Zhang Y, Turanov AA, Hatfield DL, Gladyshev VN. In silico identification of genes involved in selenium metabolism: evidence for a third selenium utilization trait. BMC Genomics. 2008; 9:251.
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  101. Shrimali RK, Irons RD, Carlson BA, Sano Y, Gladyshev VN, Park JM, Hatfield DL. Selenoproteins mediate T cell immunity through an antioxidant mechanism. J Biol Chem. 2008 Jul 18; 283(29):20181-5.
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  102. Bonilla M, Denicola A, Novoselov SV, Turanov AA, Protasio A, Izmendi D, Gladyshev VN, Salinas G. Platyhelminth mitochondrial and cytosolic redox homeostasis is controlled by a single thioredoxin glutathione reductase and dependent on selenium and glutathione. J Biol Chem. 2008 Jun 27; 283(26):17898-907.
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  103. Zhang Y, Gladyshev VN. Molybdoproteomes and evolution of molybdenum utilization. J Mol Biol. 2008 Jun 13; 379(4):881-99.
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  104. Lobanov AV, Hatfield DL, Gladyshev VN. Reduced reliance on the trace element selenium during evolution of mammals. Genome Biol. 2008; 9(3):R62.
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  105. Ridge PG, Zhang Y, Gladyshev VN. Comparative genomic analyses of copper transporters and cuproproteomes reveal evolutionary dynamics of copper utilization and its link to oxygen. PLoS One. 2008; 3(1):e1378.
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  106. Lobanov AV, Hatfield DL, Gladyshev VN. Selenoproteinless animals: selenophosphate synthetase SPS1 functions in a pathway unrelated to selenocysteine biosynthesis. Protein Sci. 2008 Jan; 17(1):176-82.
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  107. Ganichkin OM, Xu XM, Carlson BA, Mix H, Hatfield DL, Gladyshev VN, Wahl MC. Structure and catalytic mechanism of eukaryotic selenocysteine synthase. J Biol Chem. 2008 Feb 29; 283(9):5849-65.
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  108. Xu XM, Carlson BA, Zhang Y, Mix H, Kryukov GV, Glass RS, Berry MJ, Gladyshev VN, Hatfield DL. New developments in selenium biochemistry: selenocysteine biosynthesis in eukaryotes and archaea. Biol Trace Elem Res. 2007 Dec; 119(3):234-41.
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  109. Zhang Y, Zhou Y, Schweizer U, Savaskan NE, Hua D, Kipnis J, Hatfield DL, Gladyshev VN. Comparative analysis of selenocysteine machinery and selenoproteome gene expression in mouse brain identifies neurons as key functional sites of selenium in mammals. J Biol Chem. 2008 Jan 25; 283(4):2427-38.
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  110. Sengupta A, Carlson BA, Hoffmann VJ, Gladyshev VN, Hatfield DL. Loss of housekeeping selenoprotein expression in mouse liver modulates lipoprotein metabolism. Biochem Biophys Res Commun. 2008 Jan 18; 365(3):446-52.
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  111. Kim HY, Gladyshev VN. Methionine sulfoxide reductases: selenoprotein forms and roles in antioxidant protein repair in mammals. Biochem J. 2007 Nov 1; 407(3):321-9.
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  112. Yoo MH, Xu XM, Carlson BA, Patterson AD, Gladyshev VN, Hatfield DL. Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication. PLoS One. 2007; 2(10):e1112.
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  113. Merchant SS, Prochnik SE, Vallon O, Harris EH, Karpowicz SJ, Witman GB, Terry A, Salamov A, Fritz-Laylin LK, Maréchal-Drouard L, Marshall WF, Qu LH, Nelson DR, Sanderfoot AA, Spalding MH, Kapitonov VV, Ren Q, Ferris P, Lindquist E, Shapiro H, Lucas SM, Grimwood J, Schmutz J, Cardol P, Cerutti H, Chanfreau G, Chen CL, Cognat V, Croft MT, Dent R, Dutcher S, Fernández E, Fukuzawa H, González-Ballester D, González-Halphen D, Hallmann A, Hanikenne M, Hippler M, Inwood W, Jabbari K, Kalanon M, Kuras R, Lefebvre PA, Lemaire SD, Lobanov AV, Lohr M, Manuell A, Meier I, Mets L, Mittag M, Mittelmeier T, Moroney JV, Moseley J, Napoli C, Nedelcu AM, Niyogi K, Novoselov SV, Paulsen IT, Pazour G, Purton S, Ral JP, Riaño-Pachón DM, Riekhof W, Rymarquis L, Schroda M, Stern D, Umen J, Willows R, Wilson N, Zimmer SL, Allmer J, Balk J, Bisova K, Chen CJ, Elias M, Gendler K, Hauser C, Lamb MR, Ledford H, Long JC, Minagawa J, Page MD, Pan J, Pootakham W, Roje S, Rose A, Stahlberg E, Terauchi AM, Yang P, Ball S, Bowler C, Dieckmann CL, Gladyshev VN, Green P, Jorgensen R, Mayfield S, Mueller-Roeber B, Rajamani S, Sayre RT, Brokstein P, Dubchak I, Goodstein D, Hornick L, Huang YW, Jhaveri J, Luo Y, Martínez D, Ngau WC, Otillar B, Poliakov A, Porter A, Szajkowski L, Werner G, Zhou K, Grigoriev IV, Rokhsar DS, Grossman AR. The Chlamydomonas genome reveals the evolution of key animal and plant functions. Science. 2007 Oct 12; 318(5848):245-50.
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  114. Aachmann FL, Fomenko DE, Soragni A, Gladyshev VN, Dikiy A. Solution structure of selenoprotein W and NMR analysis of its interaction with 14-3-3 proteins. J Biol Chem. 2007 Dec 21; 282(51):37036-44.
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  115. Carlson BA, Moustafa ME, Sengupta A, Schweizer U, Shrimali R, Rao M, Zhong N, Wang S, Feigenbaum L, Lee BJ, Gladyshev VN, Hatfield DL. Selective restoration of the selenoprotein population in a mouse hepatocyte selenoproteinless background with different mutant selenocysteine tRNAs lacking Um34. J Biol Chem. 2007 Nov 9; 282(45):32591-602.
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  116. Shchedrina VA, Novoselov SV, Malinouski MY, Gladyshev VN. Identification and characterization of a selenoprotein family containing a diselenide bond in a redox motif. Proc Natl Acad Sci U S A. 2007 Aug 28; 104(35):13919-24.
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  117. Sal LS, Aachmann FL, Kim HY, Gladyshev VN, Dikiy A. NMR assignments of 1H, 13C and 15N spectra of methionine sulfoxide reductase B1 from Mus musculus. Biomol NMR Assign. 2007 Jul; 1(1):131-3.
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  118. Zhang Y, Gladyshev VN. High content of proteins containing 21st and 22nd amino acids, selenocysteine and pyrrolysine, in a symbiotic deltaproteobacterium of gutless worm Olavius algarvensis. Nucleic Acids Res. 2007; 35(15):4952-63.
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  119. Dikiy A, Novoselov SV, Fomenko DE, Sengupta A, Carlson BA, Cerny RL, Ginalski K, Grishin NV, Hatfield DL, Gladyshev VN. SelT, SelW, SelH, and Rdx12: genomics and molecular insights into the functions of selenoproteins of a novel thioredoxin-like family. Biochemistry. 2007 Jun 12; 46(23):6871-82.
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  120. Su D, Berndt C, Fomenko DE, Holmgren A, Gladyshev VN. A conserved cis-proline precludes metal binding by the active site thiolates in members of the thioredoxin family of proteins. Biochemistry. 2007 Jun 12; 46(23):6903-10.
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  121. Xu XM, Carlson BA, Irons R, Mix H, Zhong N, Gladyshev VN, Hatfield DL. Selenophosphate synthetase 2 is essential for selenoprotein biosynthesis. Biochem J. 2007 May 15; 404(1):115-20.
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  122. Novoselov SV, Lobanov AV, Hua D, Kasaikina MV, Hatfield DL, Gladyshev VN. A highly efficient form of the selenocysteine insertion sequence element in protozoan parasites and its use in mammalian cells. Proc Natl Acad Sci U S A. 2007 May 8; 104(19):7857-62.
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  123. Yoo MH, Xu XM, Turanov AA, Carlson BA, Gladyshev VN, Hatfield DL. A new strategy for assessing selenoprotein function: siRNA knockdown/knock-in targeting the 3'-UTR. RNA. 2007 Jun; 13(6):921-9.
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  124. Koc A, Gladyshev VN. Methionine sulfoxide reduction and the aging process. Ann N Y Acad Sci. 2007 Apr; 1100:383-6.
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  125. Novoselov SV, Kryukov GV, Xu XM, Carlson BA, Hatfield DL, Gladyshev VN. Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern. J Biol Chem. 2007 Apr 20; 282(16):11960-8.
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  126. Fomenko DE, Xing W, Adair BM, Thomas DJ, Gladyshev VN. High-throughput identification of catalytic redox-active cysteine residues. Science. 2007 Jan 19; 315(5810):387-9.
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  127. Lobanov AV, Fomenko DE, Zhang Y, Sengupta A, Hatfield DL, Gladyshev VN. Evolutionary dynamics of eukaryotic selenoproteomes: large selenoproteomes may associate with aquatic life and small with terrestrial life. Genome Biol. 2007; 8(9):R198.
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  128. Labunskyy VM, Hatfield DL, Gladyshev VN. The Sep15 protein family: roles in disulfide bond formation and quality control in the endoplasmic reticulum. IUBMB Life. 2007 Jan; 59(1):1-5.
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  129. Xu XM, Carlson BA, Mix H, Zhang Y, Saira K, Glass RS, Berry MJ, Gladyshev VN, Hatfield DL. Biosynthesis of selenocysteine on its tRNA in eukaryotes. PLoS Biol. 2007 Jan; 5(1):e4.
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  130. Mix H, Lobanov AV, Gladyshev VN. SECIS elements in the coding regions of selenoprotein transcripts are functional in higher eukaryotes. Nucleic Acids Res. 2007; 35(2):414-23.
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  131. Shrimali RK, Weaver JA, Miller GF, Starost MF, Carlson BA, Novoselov SV, Kumaraswamy E, Gladyshev VN, Hatfield DL. Selenoprotein expression is essential in endothelial cell development and cardiac muscle function. Neuromuscul Disord. 2007 Feb; 17(2):135-42.
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  132. Kim HY, Fomenko DE, Yoon YE, Gladyshev VN. Catalytic advantages provided by selenocysteine in methionine-S-sulfoxide reductases. Biochemistry. 2006 Nov 21; 45(46):13697-704.
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  133. Fernando MR, Lechner JM, Löfgren S, Gladyshev VN, Lou MF. Mitochondrial thioltransferase (glutaredoxin 2) has GSH-dependent and thioredoxin reductase-dependent peroxidase activities in vitro and in lens epithelial cells. FASEB J. 2006 Dec; 20(14):2645-7.
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  134. Zhang Y, Romero H, Salinas G, Gladyshev VN. Dynamic evolution of selenocysteine utilization in bacteria: a balance between selenoprotein loss and evolution of selenocysteine from redox active cysteine residues. Genome Biol. 2006; 7(10):R94.
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  135. Lobanov AV, Gromer S, Salinas G, Gladyshev VN. Selenium metabolism in Trypanosoma: characterization of selenoproteomes and identification of a Kinetoplastida-specific selenoprotein. Nucleic Acids Res. 2006; 34(14):4012-24.
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  136. Turanov AA, Su D, Gladyshev VN. Characterization of alternative cytosolic forms and cellular targets of mouse mitochondrial thioredoxin reductase. J Biol Chem. 2006 Aug 11; 281(32):22953-63.
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  137. Lobanov AV, Kryukov GV, Hatfield DL, Gladyshev VN. Is there a twenty third amino acid in the genetic code? Trends Genet. 2006 Jul; 22(7):357-60.
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  138. Eckenroth B, Harris K, Turanov AA, Gladyshev VN, Raines RT, Hondal RJ. Semisynthesis and characterization of mammalian thioredoxin reductase. Biochemistry. 2006 Apr 25; 45(16):5158-70.
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  139. Yoo MH, Xu XM, Carlson BA, Gladyshev VN, Hatfield DL. Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells. J Biol Chem. 2006 May 12; 281(19):13005-8.
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  140. Kim HY, Gladyshev VN. Alternative first exon splicing regulates subcellular distribution of methionine sulfoxide reductases. BMC Mol Biol. 2006; 7:11.
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  141. Novoselov SV, Hua D, Lobanov AV, Gladyshev VN. Identification and characterization of Fep15, a new selenocysteine-containing member of the Sep15 protein family. Biochem J. 2006 Mar 15; 394(Pt 3):575-9.
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  142. Lobanov AV, Delgado C, Rahlfs S, Novoselov SV, Kryukov GV, Gromer S, Hatfield DL, Becker K, Gladyshev VN. The Plasmodium selenoproteome. Nucleic Acids Res. 2006; 34(2):496-505.
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  143. Hatfield DL, Carlson BA, Xu XM, Mix H, Gladyshev VN. Selenocysteine incorporation machinery and the role of selenoproteins in development and health. Prog Nucleic Acid Res Mol Biol. 2006; 81:97-142.
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  144. Novoselov SV, Calvisi DF, Labunskyy VM, Factor VM, Carlson BA, Fomenko DE, Moustafa ME, Hatfield DL, Gladyshev VN. Selenoprotein deficiency and high levels of selenium compounds can effectively inhibit hepatocarcinogenesis in transgenic mice. Oncogene. 2005 Dec 1; 24(54):8003-11.
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  145. Ferguson AD, Labunskyy VM, Fomenko DE, Araç D, Chelliah Y, Amezcua CA, Rizo J, Gladyshev VN, Deisenhofer J. NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family. J Biol Chem. 2006 Feb 10; 281(6):3536-43.
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  146. Kim HY, Gladyshev VN. Different catalytic mechanisms in mammalian selenocysteine- and cysteine-containing methionine-R-sulfoxide reductases. PLoS Biol. 2005 Dec; 3(12):e375.
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  147. Sun QA, Su D, Novoselov SV, Carlson BA, Hatfield DL, Gladyshev VN. Reaction mechanism and regulation of mammalian thioredoxin/glutathione reductase. Biochemistry. 2005 Nov 8; 44(44):14528-37.
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  148. Castellano S, Lobanov AV, Chapple C, Novoselov SV, Albrecht M, Hua D, Lescure A, Lengauer T, Krol A, Gladyshev VN, Guigó R. Diversity and functional plasticity of eukaryotic selenoproteins: identification and characterization of the SelJ family. Proc Natl Acad Sci U S A. 2005 Nov 8; 102(45):16188-93.
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  149. Xu XM, Mix H, Carlson BA, Grabowski PJ, Gladyshev VN, Berry MJ, Hatfield DL. Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery. J Biol Chem. 2005 Dec 16; 280(50):41568-75.
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  150. Biterova EI, Turanov AA, Gladyshev VN, Barycki JJ. Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism. Proc Natl Acad Sci U S A. 2005 Oct 18; 102(42):15018-23.
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  151. Labunskyy VM, Ferguson AD, Fomenko DE, Chelliah Y, Hatfield DL, Gladyshev VN. A novel cysteine-rich domain of Sep15 mediates the interaction with UDP-glucose:glycoprotein glucosyltransferase. J Biol Chem. 2005 Nov 11; 280(45):37839-45.
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  152. Romero H, Zhang Y, Gladyshev VN, Salinas G. Evolution of selenium utilization traits. Genome Biol. 2005; 6(8):R66.
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  153. Kim HY, Gladyshev VN. Role of structural and functional elements of mouse methionine-S-sulfoxide reductase in its subcellular distribution. Biochemistry. 2005 Jun 7; 44(22):8059-67.
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  154. Su D, Novoselov SV, Sun QA, Moustafa ME, Zhou Y, Oko R, Hatfield DL, Gladyshev VN. Mammalian selenoprotein thioredoxin-glutathione reductase. Roles in disulfide bond formation and sperm maturation. J Biol Chem. 2005 Jul 15; 280(28):26491-8.
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  155. Su D, Li Y, Gladyshev VN. Selenocysteine insertion directed by the 3'-UTR SECIS element in Escherichia coli. Nucleic Acids Res. 2005; 33(8):2486-92.
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  156. Taskov K, Chapple C, Kryukov GV, Castellano S, Lobanov AV, Korotkov KV, Guigó R, Gladyshev VN. Nematode selenoproteome: the use of the selenocysteine insertion system to decode one codon in an animal genome? Nucleic Acids Res. 2005; 33(7):2227-38.
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  157. Shrimali RK, Lobanov AV, Xu XM, Rao M, Carlson BA, Mahadeo DC, Parent CA, Gladyshev VN, Hatfield DL. Selenocysteine tRNA identification in the model organisms Dictyostelium discoideum and Tetrahymena thermophila. Biochem Biophys Res Commun. 2005 Apr 1; 329(1):147-51.
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  158. Zhang Y, Gladyshev VN. An algorithm for identification of bacterial selenocysteine insertion sequence elements and selenoprotein genes. Bioinformatics. 2005 Jun 1; 21(11):2580-9.
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  159. Zhang Y, Fomenko DE, Gladyshev VN. The microbial selenoproteome of the Sargasso Sea. Genome Biol. 2005; 6(4):R37.
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  160. Zhang Y, Baranov PV, Atkins JF, Gladyshev VN. Pyrrolysine and selenocysteine use dissimilar decoding strategies. J Biol Chem. 2005 May 27; 280(21):20740-51.
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  161. Carlson BA, Xu XM, Gladyshev VN, Hatfield DL. Selective rescue of selenoprotein expression in mice lacking a highly specialized methyl group in selenocysteine tRNA. J Biol Chem. 2005 Feb 18; 280(7):5542-8.
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  162. Su D, Gladyshev VN. Alternative splicing involving the thioredoxin reductase module in mammals: a glutaredoxin-containing thioredoxin reductase 1. Biochemistry. 2004 Sep 28; 43(38):12177-88.
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  163. Carlson BA, Xu XM, Kryukov GV, Rao M, Berry MJ, Gladyshev VN, Hatfield DL. Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase. Proc Natl Acad Sci U S A. 2004 Aug 31; 101(35):12848-53.
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  164. Kim HY, Gladyshev VN. Characterization of mouse endoplasmic reticulum methionine-R-sulfoxide reductase. Biochem Biophys Res Commun. 2004 Aug 6; 320(4):1277-83.
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  165. Koc A, Gasch AP, Rutherford JC, Kim HY, Gladyshev VN. Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging. Proc Natl Acad Sci U S A. 2004 May 25; 101(21):7999-8004.
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  166. Kryukov GV, Gladyshev VN. The prokaryotic selenoproteome. EMBO Rep. 2004 May; 5(5):538-43.
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  167. Castellano S, Novoselov SV, Kryukov GV, Lescure A, Blanco E, Krol A, Gladyshev VN, Guigó R. Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution. EMBO Rep. 2004 Jan; 5(1):71-7.
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  168. Gladyshev VN, Kryukov GV, Fomenko DE, Hatfield DL. Identification of trace element-containing proteins in genomic databases. Annu Rev Nutr. 2004; 24:579-96.
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  169. Kim HY, Gladyshev VN. Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases. Mol Biol Cell. 2004 Mar; 15(3):1055-64.
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  170. Carlson BA, Novoselov SV, Kumaraswamy E, Lee BJ, Anver MR, Gladyshev VN, Hatfield DL. Specific excision of the selenocysteine tRNA[Ser]Sec (Trsp) gene in mouse liver demonstrates an essential role of selenoproteins in liver function. J Biol Chem. 2004 Feb 27; 279(9):8011-7.
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  171. Kwon SY, Badenhorst P, Martin-Romero FJ, Carlson BA, Paterson BM, Gladyshev VN, Lee BJ, Hatfield DL. The Drosophila selenoprotein BthD is required for survival and has a role in salivary gland development. Mol Cell Biol. 2003 Dec; 23(23):8495-504.
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  172. Fomenko DE, Gladyshev VN. Identity and functions of CxxC-derived motifs. Biochemistry. 2003 Sep 30; 42(38):11214-25.
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  173. Thisse C, Degrave A, Kryukov GV, Gladyshev VN, Obrecht-Pflumio S, Krol A, Thisse B, Lescure A. Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafish. Gene Expr Patterns. 2003 Aug; 3(4):525-32.
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  174. Rao M, Carlson BA, Novoselov SV, Weeks DP, Gladyshev VN, Hatfield DL. Chlamydomonas reinhardtii selenocysteine tRNA[Ser]Sec. RNA. 2003 Aug; 9(8):923-30.
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  175. Fomenko DE, Gladyshev VN. Genomics perspective on disulfide bond formation. Antioxid Redox Signal. 2003 Aug; 5(4):397-402.
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  176. Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN. Characterization of mammalian selenoproteomes. Science. 2003 May 30; 300(5624):1439-43.
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  177. Kumaraswamy E, Carlson BA, Morgan F, Miyoshi K, Robinson GW, Su D, Wang S, Southon E, Tessarollo L, Lee BJ, Gladyshev VN, Hennighausen L, Hatfield DL. Selective removal of the selenocysteine tRNA [Ser]Sec gene (Trsp) in mouse mammary epithelium. Mol Cell Biol. 2003 Mar; 23(5):1477-88.
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  178. Novoselov SV, Gladyshev VN. Non-animal origin of animal thioredoxin reductases: implications for selenocysteine evolution and evolution of protein function through carboxy-terminal extensions. Protein Sci. 2003 Feb; 12(2):372-8.
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  179. Xu XM, Carlson BA, Grimm TA, Kutza J, Berry MJ, Arreola R, Fields KH, Shanmugam I, Jeang KT, Oroszlan S, Combs GF, Marx PA, Gladyshev VN, Clouse KA, Hatfield DL. Rhesus monkey simian immunodeficiency virus infection as a model for assessing the role of selenium in AIDS. J Acquir Immune Defic Syndr. 2002 Dec 15; 31(5):453-63.
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  180. Fomenko DE, Gladyshev VN. CxxS: fold-independent redox motif revealed by genome-wide searches for thiol/disulfide oxidoreductase function. Protein Sci. 2002 Oct; 11(10):2285-96.
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  181. Kumar RA, Koc A, Cerny RL, Gladyshev VN. Reaction mechanism, evolutionary analysis, and role of zinc in Drosophila methionine-R-sulfoxide reductase. J Biol Chem. 2002 Oct 4; 277(40):37527-35.
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  182. Novoselov SV, Rao M, Onoshko NV, Zhi H, Kryukov GV, Xiang Y, Weeks DP, Hatfield DL, Gladyshev VN. Selenoproteins and selenocysteine insertion system in the model plant cell system, Chlamydomonas reinhardtii. EMBO J. 2002 Jul 15; 21(14):3681-93.
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  183. Hatfield DL, Gladyshev VN. How selenium has altered our understanding of the genetic code. Mol Cell Biol. 2002 Jun; 22(11):3565-76.
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  184. Kryukov GV, Kumar RA, Koc A, Sun Z, Gladyshev VN. Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase. Proc Natl Acad Sci U S A. 2002 Apr 2; 99(7):4245-50.
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  185. Korotkov KV, Novoselov SV, Hatfield DL, Gladyshev VN. Mammalian selenoprotein in which selenocysteine (Sec) incorporation is supported by a new form of Sec insertion sequence element. Mol Cell Biol. 2002 Mar; 22(5):1402-11.
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  186. Gladyshev VN. Thioredoxin and peptide methionine sulfoxide reductase: convergence of similar structure and function in distinct structural folds. Proteins. 2002 Feb 1; 46(2):149-52.
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  187. Gladyshev VN. Comparison of selenium-containing molybdoenzymes. Met Ions Biol Syst. 2002; 39:655-72.
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  188. Kumaraswamy E, Korotkov KV, Diamond AM, Gladyshev VN, Hatfield DL. Genetic and functional analysis of mammalian Sep15 selenoprotein. Methods Enzymol. 2002; 347:187-97.
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  189. Kryukov GV, Gladyshev VN. Mammalian selenoprotein gene signature: identification and functional analysis of selenoprotein genes using bioinformatics methods. Methods Enzymol. 2002; 347:84-100.
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  190. Sun QA, Gladyshev VN. Redox regulation of cell signaling by thioredoxin reductases. Methods Enzymol. 2002; 347:451-61.
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  191. Gladyshev VN, Liu A, Novoselov SV, Krysan K, Sun QA, Kryukov VM, Kryukov GV, Lou MF. Identification and characterization of a new mammalian glutaredoxin (thioltransferase), Grx2. J Biol Chem. 2001 Aug 10; 276(32):30374-80.
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  192. Martin-Romero FJ, Kryukov GV, Lobanov AV, Carlson BA, Lee BJ, Gladyshev VN, Hatfield DL. Selenium metabolism in Drosophila: selenoproteins, selenoprotein mRNA expression, fertility, and mortality. J Biol Chem. 2001 Aug 10; 276(32):29798-804.
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  193. Moustafa ME, Carlson BA, El-Saadani MA, Kryukov GV, Sun QA, Harney JW, Hill KE, Combs GF, Feigenbaum L, Mansur DB, Burk RF, Berry MJ, Diamond AM, Lee BJ, Gladyshev VN, Hatfield DL. Selective inhibition of selenocysteine tRNA maturation and selenoprotein synthesis in transgenic mice expressing isopentenyladenosine-deficient selenocysteine tRNA. Mol Cell Biol. 2001 Jun; 21(11):3840-52.
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  194. Gladyshev VN, Hatfield DL. Analysis of selenocysteine-containing proteins. Curr Protoc Protein Sci. 2001 May; Chapter 3:Unit 3.8.
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  195. Sun QA, Kirnarsky L, Sherman S, Gladyshev VN. Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems. Proc Natl Acad Sci U S A. 2001 Mar 27; 98(7):3673-8.
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  196. Hu YJ, Korotkov KV, Mehta R, Hatfield DL, Rotimi CN, Luke A, Prewitt TE, Cooper RS, Stock W, Vokes EE, Dolan ME, Gladyshev VN, Diamond AM. Distribution and functional consequences of nucleotide polymorphisms in the 3'-untranslated region of the human Sep15 gene. Cancer Res. 2001 Mar 1; 61(5):2307-10.
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  197. Korotkov KV, Kumaraswamy E, Zhou Y, Hatfield DL, Gladyshev VN. Association between the 15-kDa selenoprotein and UDP-glucose:glycoprotein glucosyltransferase in the endoplasmic reticulum of mammalian cells. J Biol Chem. 2001 May 4; 276(18):15330-6.
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  198. Gladyshev VN, Kryukov GV. Evolution of selenocysteine-containing proteins: significance of identification and functional characterization of selenoproteins. Biofactors. 2001; 14(1-4):87-92.
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  199. Kryukov GV, Gladyshev VN. Selenium metabolism in zebrafish: multiplicity of selenoprotein genes and expression of a protein containing 17 selenocysteine residues. Genes Cells. 2000 Dec; 5(12):1049-60.
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  200. Kumaraswamy E, Malykh A, Korotkov KV, Kozyavkin S, Hu Y, Kwon SY, Moustafa ME, Carlson BA, Berry MJ, Lee BJ, Hatfield DL, Diamond AM, Gladyshev VN. Structure-expression relationships of the 15-kDa selenoprotein gene. Possible role of the protein in cancer etiology. J Biol Chem. 2000 Nov 10; 275(45):35540-7.
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  201. Sun QA, Zappacosta F, Factor VM, Wirth PJ, Hatfield DL, Gladyshev VN. Heterogeneity within animal thioredoxin reductases. Evidence for alternative first exon splicing. J Biol Chem. 2001 Feb 2; 276(5):3106-14.
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  202. Mansur DB, Hao H, Gladyshev VN, Korotkov KV, Hu Y, Moustafa ME, El-Saadani MA, Carlson BA, Hatfield DL, Diamond AM. Multiple levels of regulation of selenoprotein biosynthesis revealed from the analysis of human glioma cell lines. Biochem Pharmacol. 2000 Aug 15; 60(4):489-97.
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  203. Kryukov GV, Kryukov VM, Gladyshev VN. New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements. J Biol Chem. 1999 Nov 26; 274(48):33888-97.
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  204. Sun QA, Wu Y, Zappacosta F, Jeang KT, Lee BJ, Hatfield DL, Gladyshev VN. Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases. J Biol Chem. 1999 Aug 27; 274(35):24522-30.
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  205. Gladyshev VN, Krause M, Xu XM, Korotkov KV, Kryukov GV, Sun QA, Lee BJ, Wootton JC, Hatfield DL. Selenocysteine-containing thioredoxin reductase in C. elegans. Biochem Biophys Res Commun. 1999 Jun 7; 259(2):244-9.
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  206. Gladyshev VN, Hatfield DL. Selenocysteine-containing proteins in mammals. J Biomed Sci. 1999 May-Jun; 6(3):151-60.
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  207. Gladyshev VN, Stadtman TC, Hatfield DL, Jeang KT. Levels of major selenoproteins in T cells decrease during HIV infection and low molecular mass selenium compounds increase. Proc Natl Acad Sci U S A. 1999 Feb 2; 96(3):835-9.
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  208. Gladyshev VN, Factor VM, Housseau F, Hatfield DL. Contrasting patterns of regulation of the antioxidant selenoproteins, thioredoxin reductase, and glutathione peroxidase, in cancer cells. Biochem Biophys Res Commun. 1998 Oct 20; 251(2):488-93.
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  209. Gladyshev VN, Jeang KT, Wootton JC, Hatfield DL. A new human selenium-containing protein. Purification, characterization, and cDNA sequence. J Biol Chem. 1998 Apr 10; 273(15):8910-5.
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  210. Klyachko NL, Vakula SV, Gladyshev VN, Tishkov VI, Levashov AV. Formate dehydrogenase in a reversed micelle system: regulation of catalytic activity and oligomeric composition of the enzyme. Biochemistry (Mosc). 1997 Dec; 62(12):1439-43.
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  211. Boyington JC, Gladyshev VN, Khangulov SV, Stadtman TC, Sun PD. Crystal structure of formate dehydrogenase H: catalysis involving Mo, molybdopterin, selenocysteine, and an Fe4S4 cluster. Science. 1997 Feb 28; 275(5304):1305-8.
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  212. Gladyshev VN, Jeang KT, Stadtman TC. Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene. Proc Natl Acad Sci U S A. 1996 Jun 11; 93(12):6146-51.
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  213. Gladyshev VN, Boyington JC, Khangulov SV, Grahame DA, Stadtman TC, Sun PD. Characterization of crystalline formate dehydrogenase H from Escherichia coli. Stabilization, EPR spectroscopy, and preliminary crystallographic analysis. J Biol Chem. 1996 Apr 5; 271(14):8095-100.
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  214. Gladyshev VN, Khangulov SV, Stadtman TC. Properties of the selenium- and molybdenum-containing nicotinic acid hydroxylase from Clostridium barkeri. Biochemistry. 1996 Jan 9; 35(1):212-23.
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  215. Gladyshev VN, Lecchi P. Identification of molybdopterins in molybdenum- and selenium-containing enzymes. Biofactors. 1995-1996; 5(2):93-7.
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  216. Tamura T, Gladyshev V, Liu SY, Stadtman TC. The mutual sparing effects of selenium and vitamin E in animal nutrition may be further explained by the discovery that mammalian thioredoxin reductase is a selenoenzyme. Biofactors. 1995-1996; 5(2):99-102.
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  217. Gladyshev VN, Khangulov SV, Axley MJ, Stadtman TC. Coordination of selenium to molybdenum in formate dehydrogenase H from Escherichia coli. Proc Natl Acad Sci U S A. 1994 Aug 2; 91(16):7708-11.
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  218. Gladyshev VN, Khangulov SV, Stadtman TC. Nicotinic acid hydroxylase from Clostridium barkeri: electron paramagnetic resonance studies show that selenium is coordinated with molybdenum in the catalytically active selenium-dependent enzyme. Proc Natl Acad Sci U S A. 1994 Jan 4; 91(1):232-6.
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