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John M Higgins, M.D.

TitleAssistant Professor of Systems Biology
InstitutionMassachusetts General Hospital
DepartmentSystems Biology
AddressMassachusetts General Hospital
Center for Systems Biology
185 Cambridge St
Boston MA 02114
Phone617/643-6129
Fax617/643-6133

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Feijó Delgado F, Cermak N, Hecht VC, Son S, Li Y, Knudsen SM, Olcum S, Higgins JM, Chen J, Grover WH, Manalis SR. Intracellular water exchange for measuring the dry mass, water mass and changes in chemical composition of living cells. PLoS One. 2013; 8(7):e67590.
    View in: PubMed
  2. Byun H, Hillman TR, Higgins JM, Diez-Silva M, Peng Z, Dao M, Dasari RR, Suresh S, Park Y. Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient. Acta Biomater. 2012 Nov; 8(11):4130-8.
    View in: PubMed
  3. Kim Y, Higgins JM, Dasari RR, Suresh S, Park Y. Anisotropic light scattering of individual sickle red blood cells. J Biomed Opt. 2012 Apr; 17(4):040501.
    View in: PubMed
  4. Wood DK, Soriano A, Mahadevan L, Higgins JM, Bhatia SN. A biophysical indicator of vaso-occlusive risk in sickle cell disease. Sci Transl Med. 2012 Feb 29; 4(123):123ra26.
    View in: PubMed
  5. Leuschner F, Rauch PJ, Ueno T, Gorbatov R, Marinelli B, Lee WW, Dutta P, Wei Y, Robbins C, Iwamoto Y, Sena B, Chudnovskiy A, Panizzi P, Keliher E, Higgins JM, Libby P, Moskowitz MA, Pittet MJ, Swirski FK, Weissleder R, Nahrendorf M. Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis. J Exp Med. 2012 Jan 16; 209(1):123-37.
    View in: PubMed
  6. Baron JM, Higgins JM, Dzik WH. A revised timeline for the origin of Plasmodium falciparum as a human pathogen. J Mol Evol. 2011 Dec; 73(5-6):297-304.
    View in: PubMed
  7. Grover WH, Bryan AK, Diez-Silva M, Suresh S, Higgins JM, Manalis SR. Measuring single-cell density. Proc Natl Acad Sci U S A. 2011 Jul 5; 108(27):10992-6.
    View in: PubMed
  8. Higgins JM, Mahadevan L. Physiological and pathological population dynamics of circulating human red blood cells. Proc Natl Acad Sci U S A. 2010 Nov 23; 107(47):20587-92.
    View in: PubMed
  9. Setoguchi S, Higgins JM, Mogun H, Mootha VK, Avorn J. Propranolol and the risk of hospitalized myopathy: translating chemical genomics findings into population-level hypotheses. Am Heart J. 2010 Mar; 159(3):428-33.
    View in: PubMed
  10. Higgins JM, Eddington DT, Bhatia SN, Mahadevan L. Statistical dynamics of flowing red blood cells by morphological image processing. PLoS Comput Biol. 2009 Feb; 5(2):e1000288.
    View in: PubMed
  11. Higgins JM, Sloan SR. Stochastic modeling of human RBC alloimmunization: evidence for a distinct population of immunologic responders. Blood. 2008 Sep 15; 112(6):2546-53.
    View in: PubMed
  12. Sabeti PC, Reich DE, Higgins JM, Levine HZ, Richter DJ, Schaffner SF, Gabriel SB, Platko JV, Patterson NJ, McDonald GJ, Ackerman HC, Campbell SJ, Altshuler D, Cooper R, Kwiatkowski D, Ward R, Lander ES. Detecting recent positive selection in the human genome from haplotype structure. Nature. 2002 Oct 24; 419(6909):832-7.
    View in: PubMed
  13. Reich DE, Schaffner SF, Daly MJ, McVean G, Mullikin JC, Higgins JM, Richter DJ, Lander ES, Altshuler D. Human genome sequence variation and the influence of gene history, mutation and recombination. Nat Genet. 2002 Sep; 32(1):135-42.
    View in: PubMed
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