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Last Name
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John G Flanagan, Ph.D.

TitleProfessor of Cell Biology
InstitutionHarvard Medical School
DepartmentCell Biology
AddressHarvard Medical School
Cell Biology
240 Longwood Ave
Boston MA 02115
Phone617/432-4096
Fax617/432-1144

 Mentoring 
 current student opportunities
Available: 10/05/12, Expires: 12/31/13

Current projects: (1) How do axonal growth cones respond to guidance cues? Our particular interest is in novel RNA-based mechanisms. (2) Methods to promote CNS axon regeneration. Approaches include biochemistry, cell culture, in vivo studies in chick and mouse, and genome wide analysis of RNA interaction networks.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Preitner N, Flanagan JG. Axonal mRNA translation: an unexpected link to axon survival and the mitochondrion. Neuron. 2012 Feb 23; 73(4):629-31.
    View in: PubMed
  2. Hancock ML, Nowakowski DW, Role LW, Talmage DA, Flanagan JG. Type III neuregulin 1 regulates pathfinding of sensory axons in the developing spinal cord and periphery. Development. 2011 Nov; 138(22):4887-98.
    View in: PubMed
  3. Coles CH, Shen Y, Tenney AP, Siebold C, Sutton GC, Lu W, Gallagher JT, Jones EY, Flanagan JG, Aricescu AR. Proteoglycan-specific molecular switch for RPTPs clustering and neuronal extension. Science. 2011 Apr 22; 332(6028):484-8.
    View in: PubMed
  4. Eilaghi A, Flanagan JG, Tertinegg I, Simmons CA, Wayne Brodland G, Ross Ethier C. Biaxial mechanical testing of human sclera. J Biomech. 2010 Jun 18; 43(9):1696-701.
    View in: PubMed
  5. Tcherkezian J, Brittis PA, Thomas F, Roux PP, Flanagan JG. Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Cell. 2010 May 14; 141(4):632-44.
    View in: PubMed
  6. Buys YM, Alasbali T, Jin YP, Smith M, Gouws P, Geffen N, Flanagan JG, Shapiro CM, Trope GE. Effect of sleeping in a head-up position on intraocular pressure in patients with glaucoma. Ophthalmology. 2010 Jul; 117(7):1348-51.
    View in: PubMed
  7. Eilaghi A, Flanagan JG, Simmons CA, Ethier CR. Effects of scleral stiffness properties on optic nerve head biomechanics. Ann Biomed Eng. 2010 Apr; 38(4):1586-92.
    View in: PubMed
  8. Norman RE, Flanagan JG, Rausch SM, Sigal IA, Tertinegg I, Eilaghi A, Portnoy S, Sled JG, Ethier CR. Dimensions of the human sclera: Thickness measurement and regional changes with axial length. Exp Eye Res. 2010 Feb; 90(2):277-84.
    View in: PubMed
  9. Venkataraman ST, Hudson C, Rachmiel R, Buys YM, Markowitz SN, Fisher JA, Trope GE, Flanagan JG. Retinal arteriolar vascular reactivity in untreated and progressive primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2010 Apr; 51(4):2043-50.
    View in: PubMed
  10. Shen Y, Tenney AP, Busch SA, Horn KP, Cuascut FX, Liu K, He Z, Silver J, Flanagan JG. PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration. Science. 2009 Oct 23; 326(5952):592-6.
    View in: PubMed
  11. Sigal IA, Flanagan JG, Tertinegg I, Ethier CR. 3D morphometry of the human optic nerve head. Exp Eye Res. 2010 Jan; 90(1):70-80.
    View in: PubMed
  12. Eilaghi A, Flanagan JG, Brodland GW, Ethier CR. Strain uniformity in biaxial specimens is highly sensitive to attachment details. J Biomech Eng. 2009 Sep; 131(9):091003.
    View in: PubMed
  13. Chen Y, Mohammadi M, Flanagan JG. Graded levels of FGF protein span the midbrain and can instruct graded induction and repression of neural mapping labels. Neuron. 2009 Jun 25; 62(6):773-80.
    View in: PubMed
  14. Lundmark PO, Trope GE, Shapiro CM, Flanagan JG. Depressive symptomatology in tertiary-care glaucoma patients. Can J Ophthalmol. 2009 Apr; 44(2):198-204.
    View in: PubMed
  15. Baba A, Akagi K, Takayanagi M, Flanagan JG, Kobayashi T, Hattori M. Fyn tyrosine kinase regulates the surface expression of glycosylphosphatidylinositol-linked ephrin via the modulation of sphingomyelin metabolism. J Biol Chem. 2009 Apr 3; 284(14):9206-14.
    View in: PubMed
  16. Rachmiel R, Trope GE, Buys YM, Flanagan JG, Chipman ML. Intermediate-term outcome and success of superior versus inferior Ahmed Glaucoma Valve implantation. J Glaucoma. 2008 Oct-Nov; 17(7):584-90.
    View in: PubMed
  17. Venkataraman ST, Hudson C, Fisher JA, Rodrigues L, Mardimae A, Flanagan JG. Retinal arteriolar and capillary vascular reactivity in response to isoxic hypercapnia. Exp Eye Res. 2008 Dec; 87(6):535-42.
    View in: PubMed
  18. Alasbali T, Smith M, Geffen N, Trope GE, Flanagan JG, Jin Y, Buys YM. Discrepancy between results and abstract conclusions in industry- vs nonindustry-funded studies comparing topical prostaglandins. Am J Ophthalmol. 2009 Jan; 147(1):33-38.e2.
    View in: PubMed
  19. Rachmiel R, Trope GE, Buys YM, Flanagan JG, Chipman ML. Ahmed glaucoma valve implantation in uveitic glaucoma versus open-angle glaucoma patients. Can J Ophthalmol. 2008 Aug; 43(4):462-7.
    View in: PubMed
  20. Qiu R, Wang X, Davy A, Wu C, Murai K, Zhang H, Flanagan JG, Soriano P, Lu Q. Regulation of neural progenitor cell state by ephrin-B. J Cell Biol. 2008 Jun 16; 181(6):973-83.
    View in: PubMed
  21. Goren D, Flanagan JG. Is flicker-defined form (FDF) dependent on the contour? J Vis. 2008; 8(4):15.1-11.
    View in: PubMed
  22. Sigal IA, Flanagan JG, Tertinegg I, Ethier CR. Modeling individual-specific human optic nerve head biomechanics. Part I: IOP-induced deformations and influence of geometry. Biomech Model Mechanobiol. 2009 Apr; 8(2):85-98.
    View in: PubMed
  23. Sigal IA, Flanagan JG, Tertinegg I, Ethier CR. Modeling individual-specific human optic nerve head biomechanics. Part II: influence of material properties. Biomech Model Mechanobiol. 2009 Apr; 8(2):99-109.
    View in: PubMed
  24. Osterfield M, Egelund R, Young LM, Flanagan JG. Interaction of amyloid precursor protein with contactins and NgCAM in the retinotectal system. Development. 2008 Mar; 135(6):1189-99.
    View in: PubMed
  25. Luo L, Flanagan JG. Development of continuous and discrete neural maps. Neuron. 2007 Oct 25; 56(2):284-300.
    View in: PubMed
  26. Chew HF, Markowitz SN, Flanagan J, Buys YM. The effect of pupil dilation on driving vision in Canada. Can J Ophthalmol. 2007 Aug; 42(4):585-91.
    View in: PubMed
  27. Sigal IA, Flanagan JG, Tertinegg I, Ethier CR. Predicted extension, compression and shearing of optic nerve head tissues. Exp Eye Res. 2007 Sep; 85(3):312-22.
    View in: PubMed
  28. Duench S, Simpson T, Jones LW, Flanagan JG, Fonn D. Assessment of variation in bulbar conjunctival redness, temperature, and blood flow. Optom Vis Sci. 2007 Jun; 84(6):511-6.
    View in: PubMed
  29. Dhillon S, Shapiro CM, Flanagan J. Sleep-disordered breathing and effects on ocular health. Can J Ophthalmol. 2007 Apr; 42(2):238-43.
    View in: PubMed
  30. Kourkoutas D, Buys YM, Flanagan JG, Hatch WV, Balian C, Trope GE. Comparison of glaucoma progression evaluated with Heidelberg retina tomograph II versus optic nerve head stereophotographs. Can J Ophthalmol. 2007 Feb; 42(1):82-8.
    View in: PubMed
  31. Chen Y, Flanagan JG. Follow your nose: axon pathfinding in olfactory map formation. Cell. 2006 Dec 1; 127(5):881-4.
    View in: PubMed
  32. Venkataraman ST, Hudson C, Fisher JA, Flanagan JG. Novel methodology to comprehensively assess retinal arteriolar vascular reactivity to hypercapnia. Microvasc Res. 2006 Nov; 72(3):101-7.
    View in: PubMed
  33. Kisilevsky M, Hudson C, Flanagan JG, Nrusimhadevara RK, Guan K, Wong T, Mandelcorn M, Lam WC, Devenyi RG. Agreement of the Heidelberg Retina Tomograph II macula edema module with fundus biomicroscopy in diabetic maculopathy. Arch Ophthalmol. 2006 Mar; 124(3):337-42.
    View in: PubMed
  34. Guan K, Hudson C, Wong T, Kisilevsky M, Nrusimhadevara RK, Lam WC, Mandelcorn M, Devenyi RG, Flanagan JG. Retinal hemodynamics in early diabetic macular edema. Diabetes. 2006 Mar; 55(3):813-8.
    View in: PubMed
  35. Johnson KG, Tenney AP, Ghose A, Duckworth AM, Higashi ME, Parfitt K, Marcu O, Heslip TR, Marsh JL, Schwarz TL, Flanagan JG, Van Vactor D. The HSPGs Syndecan and Dallylike bind the receptor phosphatase LAR and exert distinct effects on synaptic development. Neuron. 2006 Feb 16; 49(4):517-31.
    View in: PubMed
  36. Flanagan JG. Neural map specification by gradients. Curr Opin Neurobiol. 2006 Feb; 16(1):59-66.
    View in: PubMed
  37. Sehi M, Flanagan JG, Zeng L, Cook RJ, Trope GE. Anterior optic nerve capillary blood flow response to diurnal variation of mean ocular perfusion pressure in early untreated primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2005 Dec; 46(12):4581-7.
    View in: PubMed
  38. Sigal IA, Flanagan JG, Ethier CR. Factors influencing optic nerve head biomechanics. Invest Ophthalmol Vis Sci. 2005 Nov; 46(11):4189-99.
    View in: PubMed
  39. Venkataraman ST, Hudson C, Harvey E, Flanagan JG. Impact of simulated light scatter on scanning laser Doppler flowmetry. Br J Ophthalmol. 2005 Sep; 89(9):1192-5.
    View in: PubMed
  40. Ellsworth CA, Lyckman AW, Feldheim DA, Flanagan JG, Sur M. Ephrin-A2 and -A5 influence patterning of normal and novel retinal projections to the thalamus: conserved mapping mechanisms in visual and auditory thalamic targets. J Comp Neurol. 2005 Jul 25; 488(2):140-51.
    View in: PubMed
  41. Pfeiffenberger C, Cutforth T, Woods G, Yamada J, Rentería RC, Copenhagen DR, Flanagan JG, Feldheim DA. Ephrin-As and neural activity are required for eye-specific patterning during retinogeniculate mapping. Nat Neurosci. 2005 Aug; 8(8):1022-7.
    View in: PubMed
  42. Venkataraman ST, Hudson C, Fisher JA, Flanagan JG. The impact of hypercapnia on retinal capillary blood flow assessed by scanning laser Doppler flowmetry. Microvasc Res. 2005 May; 69(3):149-55.
    View in: PubMed
  43. Fingeret M, Flanagan J, Johnson C, Cavallerano A, Quinn C, Mann D, Semes L. Glaucoma without cupping. Optometry. 2005 Apr; 76(4):223-4; author reply 224-5.
    View in: PubMed
  44. Holmberg J, Armulik A, Senti KA, Edoff K, Spalding K, Momma S, Cassidy R, Flanagan JG, Frisén J. Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis. Genes Dev. 2005 Feb 15; 19(4):462-71.
    View in: PubMed
  45. Hudson C, Flanagan JG, Turner GS, Chen HC, Rawji MH, McLeod D. Exaggerated relative nasal-temporal asymmetry of macular capillary blood flow in patients with clinically significant diabetic macular oedema. Br J Ophthalmol. 2005 Feb; 89(2):142-6.
    View in: PubMed
  46. Sehi M, Flanagan JG, Zeng L, Cook RJ, Trope GE. Relative change in diurnal mean ocular perfusion pressure: a risk factor for the diagnosis of primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2005 Feb; 46(2):561-7.
    View in: PubMed
  47. Quaid PT, Simpson TL, Flanagan JG. Frequency doubling illusion: detection vs. form resolution. Optom Vis Sci. 2005 Jan; 82(1):36-42.
    View in: PubMed
  48. Sigal IA, Flanagan JG, Tertinegg I, Ethier CR. Reconstruction of human optic nerve heads for finite element modeling. Technol Health Care. 2005; 13(4):313-29.
    View in: PubMed
  49. Kantor DB, Chivatakarn O, Peer KL, Oster SF, Inatani M, Hansen MJ, Flanagan JG, Yamaguchi Y, Sretavan DW, Giger RJ, Kolodkin AL. Semaphorin 5A is a bifunctional axon guidance cue regulated by heparan and chondroitin sulfate proteoglycans. Neuron. 2004 Dec 16; 44(6):961-75.
    View in: PubMed
  50. Sigal IA, Flanagan JG, Tertinegg I, Ethier CR. Finite element modeling of optic nerve head biomechanics. Invest Ophthalmol Vis Sci. 2004 Dec; 45(12):4378-87.
    View in: PubMed
  51. Quaid PT, Flanagan JG. Defining the limits of flicker defined form: effect of stimulus size, eccentricity and number of random dots. Vision Res. 2005 Apr; 45(8):1075-84.
    View in: PubMed
  52. Schmucker D, Flanagan JG. Generation of recognition diversity in the nervous system. Neuron. 2004 Oct 14; 44(2):219-22.
    View in: PubMed
  53. Taylor CA, Senchyna M, Flanagan J, Joyce EM, Cliche DO, Boone AN, Culp-Stewart S, Thompson JE. Role of eIF5A in TNF-alpha-mediated apoptosis of lamina cribrosa cells. Invest Ophthalmol Vis Sci. 2004 Oct; 45(10):3568-76.
    View in: PubMed
  54. Bach H, Arango V, Feldheim D, Flanagan JG, Scalia F. Fiber order of the normal and regenerated optic tract of the frog (Rana pipiens). J Comp Neurol. 2004 Sep 6; 477(1):43-54.
    View in: PubMed
  55. Faingold D, Hudson C, Flanagan J, Guan K, Rawji M, Buys YM, Trope GE. Assessment of retinal hemodynamics with the Canon laser blood flowmeter after a single dose of 2% dorzolamide hydrochloride eyedrops. Can J Ophthalmol. 2004 Aug; 39(5):506-10.
    View in: PubMed
  56. Hansen MJ, Dallal GE, Flanagan JG. Retinal axon response to ephrin-as shows a graded, concentration-dependent transition from growth promotion to inhibition. Neuron. 2004 Jun 10; 42(5):717-30.
    View in: PubMed
  57. Feldheim DA, Nakamoto M, Osterfield M, Gale NW, DeChiara TM, Rohatgi R, Yancopoulos GD, Flanagan JG. Loss-of-function analysis of EphA receptors in retinotectal mapping. J Neurosci. 2004 Mar 10; 24(10):2542-50.
    View in: PubMed
  58. Quaid PT, Simpson T, Flanagan JG. Monocular and dichoptic masking effects on the frequency doubling illusion. Vision Res. 2004 Mar; 44(7):661-7.
    View in: PubMed
  59. Guan K, Hudson C, Flanagan JG. Comparison of Heidelberg Retina Tomograph II and Retinal Thickness Analyzer in the assessment of diabetic macular edema. Invest Ophthalmol Vis Sci. 2004 Feb; 45(2):610-6.
    View in: PubMed
  60. Sehi M, Flanagan JG. The effect of image alignment on capillary blood flow measurement of the neuroretinal rim using the Heidelberg retina flowmeter. Br J Ophthalmol. 2004 Feb; 88(2):204-6.
    View in: PubMed
  61. Lu Q, Sun EE, Flanagan JG. Analysis of PDZ-RGS3 function in ephrin-B reverse signaling. Methods Enzymol. 2004; 390:120-8.
    View in: PubMed
  62. Bach H, Feldheim DA, Flanagan JG, Scalia F. Persistence of graded EphA/Ephrin-A expression in the adult frog visual system. J Comp Neurol. 2003 Dec 22; 467(4):549-65.
    View in: PubMed
  63. Lundmark PO, Trope GE, Flanagan JG. The effect of simulated obstructive apnoea on intraocular pressure and pulsatile ocular blood flow in healthy young adults. Br J Ophthalmol. 2003 Nov; 87(11):1363-9.
    View in: PubMed
  64. Hudson C, Nrusimhadevara RK, Guan K, Gilmore E, Flanagan JG. Interpretation of objectively acquired retinal thickness values. Arch Ophthalmol. 2003 Sep; 121(9):1343-4; author reply 1344-5.
    View in: PubMed
  65. Dufour A, Seibt J, Passante L, Depaepe V, Ciossek T, Frisén J, Kullander K, Flanagan JG, Polleux F, Vanderhaeghen P. Area specificity and topography of thalamocortical projections are controlled by ephrin/Eph genes. Neuron. 2003 Jul 31; 39(3):453-65.
    View in: PubMed
  66. Osterfield M, Kirschner MW, Flanagan JG. Graded positional information: interpretation for both fate and guidance. Cell. 2003 May 16; 113(4):425-8.
    View in: PubMed
  67. Guan K, Hudson C, Flanagan JG. Variability and repeatability of retinal blood flow measurements using the Canon Laser Blood Flowmeter. Microvasc Res. 2003 May; 65(3):145-51.
    View in: PubMed
  68. Hudson C, Flanagan JG, Turner GS, Chen HC, Young LB, McLeod D. Correlation of a scanning laser derived oedema index and visual function following grid laser treatment for diabetic macular oedema. Br J Ophthalmol. 2003 Apr; 87(4):455-61.
    View in: PubMed
  69. Nishida K, Flanagan JG, Nakamoto M. Domain-specific olivocerebellar projection regulated by the EphA-ephrin-A interaction. Development. 2002 Dec; 129(24):5647-58.
    View in: PubMed
  70. Brittis PA, Lu Q, Flanagan JG. Axonal protein synthesis provides a mechanism for localized regulation at an intermediate target. Cell. 2002 Jul 26; 110(2):223-35.
    View in: PubMed
  71. Ionescu D, Driver HS, Heon E, Flanagan J, Shapiro CM. Sleep and daytime sleepiness in retinitis pigmentosa patients. J Sleep Res. 2001 Dec; 10(4):329-35.
    View in: PubMed
  72. Lyckman AW, Jhaveri S, Feldheim DA, Vanderhaeghen P, Flanagan JG, Sur M. Enhanced plasticity of retinothalamic projections in an ephrin-A2/A5 double mutant. J Neurosci. 2001 Oct 1; 21(19):7684-90.
    View in: PubMed
  73. Hutchings N, Hosking SL, Wild JM, Flanagan JG. Long-term fluctuation in short-wavelength automated perimetry in glaucoma suspects and glaucoma patients. Invest Ophthalmol Vis Sci. 2001 Sep; 42(10):2332-7.
    View in: PubMed
  74. Lu Q, Sun EE, Klein RS, Flanagan JG. Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction. Cell. 2001 Apr 6; 105(1):69-79.
    View in: PubMed
  75. Brittis PA, Flanagan JG. Nogo domains and a Nogo receptor: implications for axon regeneration. Neuron. 2001 Apr; 30(1):11-4.
    View in: PubMed
  76. Rawji MH, Flanagan JG. Intraocular and interocular symmetry in normal retinal capillary perfusion. J Glaucoma. 2001 Feb; 10(1):4-12.
    View in: PubMed
  77. Cheng HJ, Flanagan JG. Cloning and characterization of RTK ligands using receptor-alkaline phosphatase fusion proteins. Methods Mol Biol. 2001; 124:313-34.
    View in: PubMed
  78. Hutchings N, Wild JM, Hussey MK, Flanagan JG, Trope GE. The long-term fluctuation of the visual field in stable glaucoma. Invest Ophthalmol Vis Sci. 2000 Oct; 41(11):3429-36.
    View in: PubMed
  79. Hattori M, Osterfield M, Flanagan JG. Regulated cleavage of a contact-mediated axon repellent. Science. 2000 Aug 25; 289(5483):1360-5.
    View in: PubMed
  80. Prakash N, Vanderhaeghen P, Cohen-Cory S, Frisén J, Flanagan JG, Frostig RD. Malformation of the functional organization of somatosensory cortex in adult ephrin-A5 knock-out mice revealed by in vivo functional imaging. J Neurosci. 2000 Aug 1; 20(15):5841-7.
    View in: PubMed
  81. Vanderhaeghen P, Lu Q, Prakash N, Frisén J, Walsh CA, Frostig RD, Flanagan JG. A mapping label required for normal scale of body representation in the cortex. Nat Neurosci. 2000 Apr; 3(4):358-65.
    View in: PubMed
  82. Feldheim DA, Kim YI, Bergemann AD, Frisén J, Barbacid M, Flanagan JG. Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping. Neuron. 2000 Mar; 25(3):563-74.
    View in: PubMed
  83. Feng G, Laskowski MB, Feldheim DA, Wang H, Lewis R, Frisen J, Flanagan JG, Sanes JR. Roles for ephrins in positionally selective synaptogenesis between motor neurons and muscle fibers. Neuron. 2000 Feb; 25(2):295-306.
    View in: PubMed
  84. Williams-Lyn D, Flanagan J, Buys Y, Trope GE, Fingert J, Stone EM, Héon E. The genetic aspects of adult-onset glaucoma: a perspective from the Greater Toronto area. Can J Ophthalmol. 2000 Feb; 35(1):12-7.
    View in: PubMed
  85. Flanagan JG, Cheng HJ, Feldheim DA, Hattori M, Lu Q, Vanderhaeghen P. Alkaline phosphatase fusions of ligands or receptors as in situ probes for staining of cells, tissues, and embryos. Methods Enzymol. 2000; 327:19-35.
    View in: PubMed
  86. Flanagan JG, Cheng HJ. Alkaline phosphatase fusion proteins for molecular characterization and cloning of receptors and their ligands. Methods Enzymol. 2000; 327:198-210.
    View in: PubMed
  87. Flanagan JG. Life on the road. Nature. 1999 Oct 21; 401(6755):747-8.
    View in: PubMed
  88. Trope GE, Buys YM, Flanagan J, Wang L. Is a tight patch necessary after trabeculectomy? Br J Ophthalmol. 1999 Sep; 83(9):1006-7.
    View in: PubMed
  89. Hatch WV, Flanagan JG, Williams-Lyn DE, Buys YM, Farra T, Trope GE. Interobserver agreement of Heidelberg retina tomograph parameters. J Glaucoma. 1999 Aug; 8(4):232-7.
    View in: PubMed
  90. Van Vactor D, Flanagan JG. The middle and the end: slit brings guidance and branching together in axon pathway selection. Neuron. 1999 Apr; 22(4):649-52.
    View in: PubMed
  91. Hatch WV, Trope GE, Buys YM, Macken P, Etchells EE, Flanagan JG. Agreement in assessing glaucomatous discs in a clinical teaching setting with stereoscopic disc photographs, planimetry, and laser scanning tomography. J Glaucoma. 1999 Apr; 8(2):99-104.
    View in: PubMed
  92. Feldheim DA, Vanderhaeghen P, Hansen MJ, Frisén J, Lu Q, Barbacid M, Flanagan JG. Topographic guidance labels in a sensory projection to the forebrain. Neuron. 1998 Dec; 21(6):1303-13.
    View in: PubMed
  93. Hudson C, Flanagan JG, Turner GS, Chen HC, Young LB, McLeod D. Influence of laser photocoagulation for clinically significant diabetic macular oedema (DMO) on short-wavelength and conventional automated perimetry. Diabetologia. 1998 Nov; 41(11):1283-92.
    View in: PubMed
  94. Miedziak AI, Stefanyszyn M, Flanagan J, Eagle RC. Parry-Romberg syndrome associated with intracranial vascular malformations. Arch Ophthalmol. 1998 Sep; 116(9):1235-7.
    View in: PubMed
  95. Yan DB, Flanagan JG, Farra T, Trope GE, Ethier CR. Study of regional deformation of the optic nerve head using scanning laser tomography. Curr Eye Res. 1998 Sep; 17(9):903-16.
    View in: PubMed
  96. Hudson C, Flanagan JG, Turner GS, Chen HC, Young LB, McLeod D. Short-wavelength sensitive visual field loss in patients with clinically significant diabetic macular oedema. Diabetologia. 1998 Aug; 41(8):918-28.
    View in: PubMed
  97. Flanagan JG. Glaucoma update: epidemiology and new approaches to medical management. Ophthalmic Physiol Opt. 1998 Mar; 18(2):126-32.
    View in: PubMed
  98. Flanagan JG, Van Vactor D. Through the looking glass: axon guidance at the midline choice point. Cell. 1998 Feb 20; 92(4):429-32.
    View in: PubMed
  99. Hudson C, Flanagan JG, Turner GS, McLeod D. Scanning laser tomography Z profile signal width as an objective index of macular retinal thickening. Br J Ophthalmol. 1998 Feb; 82(2):121-30.
    View in: PubMed
  100. Bergemann AD, Zhang L, Chiang MK, Brambilla R, Klein R, Flanagan JG. Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube. Oncogene. 1998 Jan 29; 16(4):471-80.
    View in: PubMed
  101. Flanagan JG, Vanderhaeghen P. The ephrins and Eph receptors in neural development. Annu Rev Neurosci. 1998; 21:309-45.
    View in: PubMed
  102. Hatch WV, Flanagan JG, Etchells EE, Williams-Lyn DE, Trope GE. Laser scanning tomography of the optic nerve head in ocular hypertension and glaucoma. Br J Ophthalmol. 1997 Oct; 81(10):871-6.
    View in: PubMed
  103. Wild JM, Hutchings N, Hussey MK, Flanagan JG, Trope GE. Pointwise univariate linear regression of perimetric sensitivity against follow-up time in glaucoma. Ophthalmology. 1997 May; 104(5):808-15.
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  104. Prokopich CL, Flanagan JG. Gonioscopy: evaluation of the anterior chamber angle. Part II. Ophthalmic Physiol Opt. 1997 Mar; 17 Suppl 1:S9-13.
    View in: PubMed
  105. Hudson C, Charles SJ, Flanagan JG, Brahma AK, Turner GS, McLeod D. Objective morphological assessment of macular hole surgery by scanning laser tomography. Br J Ophthalmol. 1997 Feb; 81(2):107-16.
    View in: PubMed
  106. Zhang JH, Cerretti DP, Yu T, Flanagan JG, Zhou R. Detection of ligands in regions anatomically connected to neurons expressing the Eph receptor Bsk: potential roles in neuron-target interaction. J Neurosci. 1996 Nov 15; 16(22):7182-92.
    View in: PubMed
  107. Nakamoto M, Cheng HJ, Friedman GC, McLaughlin T, Hansen MJ, Yoon CH, O'Leary DD, Flanagan JG. Topographically specific effects of ELF-1 on retinal axon guidance in vitro and retinal axon mapping in vivo. Cell. 1996 Sep 6; 86(5):755-66.
    View in: PubMed
  108. Prokopich CL, Flanagan JG. Gonioscopy: evaluation of the anterior chamber angle. Part I. Ophthalmic Physiol Opt. 1996 Sep; 16 Suppl 2:S39-42.
    View in: PubMed
  109. Chiang MK, Flanagan JG. PTP-NP, a new member of the receptor protein tyrosine phosphatase family, implicated in development of nervous system and pancreatic endocrine cells. Development. 1996 Jul; 122(7):2239-50.
    View in: PubMed
  110. Hosking SL, Flanagan JG. Prospective study design for the Heidelberg Retina Tomograph: the effect of change in focus setting. Graefes Arch Clin Exp Ophthalmol. 1996 May; 234(5):306-10.
    View in: PubMed
  111. Cao Y, Chen H, Zhou L, Chiang MK, Anand-Apte B, Weatherbee JA, Wang Y, Fang F, Flanagan JG, Tsang ML. Heterodimers of placenta growth factor/vascular endothelial growth factor. Endothelial activity, tumor cell expression, and high affinity binding to Flk-1/KDR. J Biol Chem. 1996 Feb 9; 271(6):3154-62.
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  112. Hudson C, Shah S, Flanagan JG, Brahma A, Ansons A. Scanning laser tomography in benign intracranial hypertension. Lancet. 1995 Nov 25; 346(8987):1435.
    View in: PubMed
  113. Elliott DB, Patla AE, Flanagan JG, Spaulding S, Rietdyk S, Strong G, Brown S. The Waterloo Vision and Mobility Study: postural control strategies in subjects with ARM. Ophthalmic Physiol Opt. 1995 Nov; 15(6):553-9.
    View in: PubMed
  114. Bergemann AD, Cheng HJ, Brambilla R, Klein R, Flanagan JG. ELF-2, a new member of the Eph ligand family, is segmentally expressed in mouse embryos in the region of the hindbrain and newly forming somites. Mol Cell Biol. 1995 Sep; 15(9):4921-9.
    View in: PubMed
  115. Flanagan JG, Prokopich CL. Indirect fundus biomicroscopy. Ophthalmic Physiol Opt. 1995 Sep; 15 Suppl 2:S38-41.
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  116. Cheng HJ, Nakamoto M, Bergemann AD, Flanagan JG. Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map. Cell. 1995 Aug 11; 82(3):371-81.
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  117. Brambilla R, Schnapp A, Casagranda F, Labrador JP, Bergemann AD, Flanagan JG, Pasquale EB, Klein R. Membrane-bound LERK2 ligand can signal through three different Eph-related receptor tyrosine kinases. EMBO J. 1995 Jul 3; 14(13):3116-26.
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  118. Chiang MK, Flanagan JG. Interactions between the Flk-1 receptor, vascular endothelial growth factor, and cell surface proteoglycan identified with a soluble receptor reagent. Growth Factors. 1995; 12(1):1-10.
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  119. Spaulding SJ, Patla AE, Elliott DB, Flanagan J, Rietdyk S, Brown S. Waterloo Vision and Mobility Study: gait adaptations to altered surfaces in individuals with age-related maculopathy. Optom Vis Sci. 1994 Dec; 71(12):770-7.
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  120. Cheng HJ, Flanagan JG. Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases. Cell. 1994 Oct 7; 79(1):157-68.
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  121. Cheng HJ, Flanagan JG. Transmembrane kit ligand cleavage does not require a signal in the cytoplasmic domain and occurs at a site dependent on spacing from the membrane. Mol Biol Cell. 1994 Sep; 5(9):943-53.
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  122. Elliott DB, Fonn D, Flanagan J, Doughty M. Relative sensitivity of clinical tests to hydrophilic lens-induced corneal thickness changes. Optom Vis Sci. 1993 Dec; 70(12):1044-8.
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  123. Flanagan JG, Moss ID, Wild JM, Hudson C, Prokopich L, Whitaker D, O'Neill EC. Evaluation of FASTPAC: a new strategy for threshold estimation with the Humphrey Field Analyser. Graefes Arch Clin Exp Ophthalmol. 1993 Aug; 231(8):465-9.
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  124. Flanagan JG, Wild JM, Trope GE. The visual field indices in primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 1993 Jun; 34(7):2266-74.
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  125. Flanagan JG, Wild JM, Trope GE. Evaluation of FASTPAC, a new strategy for threshold estimation with the Humphrey Field Analyzer, in a glaucomatous population. Ophthalmology. 1993 Jun; 100(6):949-54.
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  126. Wild JM, Hussey MK, Flanagan JG, Trope GE. Pointwise topographical and longitudinal modeling of the visual field in glaucoma. Invest Ophthalmol Vis Sci. 1993 May; 34(6):1907-16.
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  127. Ornitz DM, Yayon A, Flanagan JG, Svahn CM, Levi E, Leder P. Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells. Mol Cell Biol. 1992 Jan; 12(1):240-7.
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  128. Flanagan JG, Chan DC, Leder P. Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant. Cell. 1991 Mar 8; 64(5):1025-35.
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  129. Kothe AC, Flanagan J, Trevino RC. True posterior ischemic optic neuropathy associated with herpes zoster ophthalmicus. Optom Vis Sci. 1990 Nov; 67(11):845-9.
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  130. Flanagan JG, Leder P. The kit ligand: a cell surface molecule altered in steel mutant fibroblasts. Cell. 1990 Oct 5; 63(1):185-94.
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  131. Flanagan JG, Kothe AC. Intracranial meningioma: an exercise in differential diagnosis. Ophthalmic Physiol Opt. 1990 Apr; 10(2):205-10.
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  132. Kothe AC, Lovasik JV, Pace R, Hrynchak PK, Flanagan JG. Visual and neural function in Leber's optic neuropathy. Optom Vis Sci. 1990 Feb; 67(2):138-47.
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  133. Styles T, Flanagan JG. Meridional differences in temporal response characteristics. Ophthalmic Physiol Opt. 1989 Oct; 9(4):405-10.
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  134. Jakobiec FA, Rini F, Char D, Orcutt J, Rootman J, Baylis H, Flanagan J. Primary liposarcoma of the orbit. Problems in the diagnosis and management of five cases. Ophthalmology. 1989 Feb; 96(2):180-91.
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  135. Flanagan JG, Leder P. neu protooncogene fused to an immunoglobulin heavy chain gene requires immunoglobulin light chain for cell surface expression and oncogenic transformation. Proc Natl Acad Sci U S A. 1988 Nov; 85(21):8057-61.
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  136. Flanagan JG, Wild JM, Wood JM. Stimulus configuration and the format of the normal sensitivity gradient. Doc Ophthalmol. 1988 Aug; 69(4):371-83.
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  137. Flanagan JG, Harding GF. Multi-channel visual evoked potentials in early compressive lesions of the chiasm. Doc Ophthalmol. 1988 Jul; 69(3):271-81.
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  138. Flanagan JG, Wild JM, Barnes DA, Gilmartin BA, Good PA, Crews SJ. The qualitative comparative analysis of the visual field using computer assisted, semi-automated and manual instrumentation: III. Clinical analysis. Doc Ophthalmol. 1984 Dec 15; 58(4):341-50.
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  139. Flanagan JG, Lefranc MP, Rabbitts TH. Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences. Cell. 1984 Mar; 36(3):681-8.
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  140. Ruchman MC, Flanagan J. Cavernous hemangiomas of the orbit. Ophthalmology. 1983 Nov; 90(11):1328-36.
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  141. Nowinski T, Flanagan J, Ruchman M. Lacrimal gland enlargement in familial sarcoidosis. Ophthalmology. 1983 Aug; 90(8):909-13.
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  142. Hornblass A, Jakobiec FA, Bosniak S, Flanagan J. The diagnosis and management of epithelial tumors of the lacrimal sac. Ophthalmology. 1980 Jun; 87(6):476-90.
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