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Rose Du, M.D., Ph.D.

TitleAssistant Professor of Neurosurgery
InstitutionBrigham and Women's Hospital
DepartmentNeurosurgery
AddressBrigham and Women's Hospital
Neurosurgery, PBB3
15 Francis St.
Boston MA 02115
Phone617/732-6600
Fax617/734-8342

 Mentoring 
 current student opportunities
Available: 03/01/12, Expires: 07/01/15

The goal of this project is to understand the correlation between mechanical stresses and the morphology of an intracranial aneurysm. The student will learn how to use computational fluid dynamics to evaluate fluid shear stress on an aneurysm wall.

Available: 12/06/10, Expires: 07/01/14

Basic and clinical research on cerebrovascular problems such as intracranial aneurysms, subarachnoid hemorrhage and cerebral vasospasm.

Available: 09/02/12, Expires: 07/01/14

Students interested in clinical projects in cerebrovascular diseases are encouraged to apply. Laboratory projects are also available.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Gross BA, Du R. Diagnosis and treatment of vascular malformations of the brain. Curr Treat Options Neurol. 2014 Jan; 16(1):279.
    View in: PubMed
  2. Lin N, Ho A, Charoenvimolphan N, Frerichs KU, Day AL, Du R. Analysis of morphological parameters to differentiate rupture status in anterior communicating artery aneurysms. PLoS One. 2013; 8(11):e79635.
    View in: PubMed
  3. Lai PM, Dasenbrock H, Lin N, Du R. The impact of insurance status on the outcomes after aneurysmal subarachnoid hemorrhage. PLoS One. 2013; 8(10):e78047.
    View in: PubMed
  4. Du R, Lin N. Response. J Neurosurg. 2013 Oct; 119(4):1077.
    View in: PubMed
  5. Chavakula V, Gross BA, Frerichs KU, Du R. Contrast-induced nephropathy in patients with aneurysmal subarachnoid hemorrhage. Neurocrit Care. 2013 Oct; 19(2):157-60.
    View in: PubMed
  6. Huang W, Gross BA, Du R. Spinal extradural arteriovenous fistulas. J Neurosurg Spine. 2013 Nov; 19(5):582-90.
    View in: PubMed
  7. Gross BA, Rosalind Lai PM, Frerichs KU, du R. Treatment Modality and Vasospasm After Aneurysmal Subarachnoid Hemorrhage. World Neurosurg. 2013 Aug 14.
    View in: PubMed
  8. Gross BA, Frerichs KU, Du R. Microsurgical treatment of a ruptured dissecting labyrinthine artery aneurysm. Clin Neurol Neurosurg. 2013 Oct; 115(10):2277-9.
    View in: PubMed
  9. Rosalind Lai PM, Lin N, Du R. Effect of teaching hospital status on outcome of aneurysm treatment. World Neurosurg. 2013 Jul 24.
    View in: PubMed
  10. Gross BA, Du R. Surgical treatment of high grade dural arteriovenous fistulae. J Clin Neurosci. 2013 Nov; 20(11):1527-32.
    View in: PubMed
  11. Gross BA, Du R. Spinal Pial (Type IV) Arteriovenous Fistulae: A Systematic Pooled Analysis of Demographics, Hemorrhage Risk, and Treatment Results. Neurosurgery. 2013 Jul; 73(1):141-51.
    View in: PubMed
  12. Gross BA, Lai PM, Frerichs KU, Du R. Angiotensin-converting enzyme-inhibitors, statins and the risk of hemorrhage from cerebral dural arteriovenous fistulae. J Clin Neurosci. 2013 Sep; 20(9):1228-31.
    View in: PubMed
  13. Gross BA, Rosalind Lai PM, Du R. Hydrocephalus after arteriovenous malformation rupture. Neurosurg Focus. 2013 May; 34(5):E11.
    View in: PubMed
  14. Patel MM, Jakobiec FA, Zakka FR, Du R, Annino DJ, Borboli-Gerogiannis S, Daniels AB. Intraorbital metastasis from solitary fibrous tumor. Ophthal Plast Reconstr Surg. 2013 May-Jun; 29(3):e76-9.
    View in: PubMed
  15. Gross BA, Thomas AJ, Frerichs KU, Du R. Cerebrovascular neurosurgery in 2012. J Clin Neurosci. 2013 Jun; 20(6):776-82.
    View in: PubMed
  16. Wong JM, Ho AL, Lin N, Zenonos GA, Martel CB, Frerichs K, Du R, Gormley WB. Radiation exposure in patients with subarachnoid hemorrhage: a quality improvement target. J Neurosurg. 2013 Jul; 119(1):215-20.
    View in: PubMed
  17. Gross BA, Rosalind Lai PM, Frerichs KU, Du R. Aspirin and Aneurysmal Subarachnoid Hemorrhage. World Neurosurg. 2013 Mar 30.
    View in: PubMed
  18. Gross BA, Du R. Microsurgical treatment of ophthalmic segment aneurysms. J Clin Neurosci. 2013 Aug; 20(8):1145-8.
    View in: PubMed
  19. Gross BA, Du R. Spinal Glomus (Type II) Arteriovenous Malformations: A Pooled Analysis of Hemorrhage Risk and Results of Intervention. Neurosurgery. 2013 Jan; 72(1):25-32.
    View in: PubMed
  20. Gross BA, Du R. Natural history of cerebral arteriovenous malformations: a meta-analysis. J Neurosurg. 2013 Feb; 118(2):437-43.
    View in: PubMed
  21. Gross BA, Puri AS, Popp AJ, Du R. Cerebral capillary telangiectasias: a meta-analysis and review of the literature. Neurosurg Rev. 2013 Apr; 36(2):187-94.
    View in: PubMed
  22. Gross BA, Du R. The natural history of Moyamoya in a North American adult cohort. J Clin Neurosci. 2013 Jan; 20(1):44-8.
    View in: PubMed
  23. Wong JM, Ziewacz JE, Ho AL, Panchmatia JR, Kim AH, Bader AM, Thompson BG, Du R, Gawande AA. Patterns in neurosurgical adverse events: open cerebrovascular neurosurgery. Neurosurg Focus. 2012 Nov; 33(5):E15.
    View in: PubMed
  24. Gross BA, Du R. Adult moyamoya after revascularization. Acta Neurochir (Wien). 2013 Feb; 155(2):247-54.
    View in: PubMed
  25. Chou SH, Feske SK, Atherton J, Konigsberg RG, De Jager PL, Du R, Ogilvy CS, Lo EH, Ning M. Early elevation of serum tumor necrosis factor-a is associated with poor outcome in subarachnoid hemorrhage. J Investig Med. 2012 Oct; 60(7):1054-8.
    View in: PubMed
  26. Lin N, Ho A, Gross BA, Pieper S, Frerichs KU, Day AL, Du R. Differences in simple morphological variables in ruptured and unruptured middle cerebral artery aneurysms. J Neurosurg. 2012 Nov; 117(5):913-9.
    View in: PubMed
  27. Gross BA, Puri AS, Du R. Basilar trunk perforator artery aneurysms. Case report and literature review. Neurosurg Rev. 2013 Jan; 36(1):163-8.
    View in: PubMed
  28. Gross BA, Du R. The natural history of cerebral dural arteriovenous fistulae. Neurosurgery. 2012 Sep; 71(3):594-602; discussion 602-3.
    View in: PubMed
  29. Gross BA, Ropper AE, Du R. Vascular complications of stereotactic radiosurgery for arteriovenous malformations. Clin Neurol Neurosurg. 2013 Jun; 115(6):713-7.
    View in: PubMed
  30. Gross BA, Du R. Cerebrovascular neurosurgery 2011. J Clin Neurosci. 2012 Oct; 19(10):1344-7.
    View in: PubMed
  31. Gross BA, Du R. Hemorrhage from arteriovenous malformations during pregnancy. Neurosurgery. 2012 Aug; 71(2):349-55; discussion 355-6.
    View in: PubMed
  32. Gross BA, Tavanaiepour D, Du R, Al-Mefty O, Dunn IF. Evolution of the posterior petrosal approach. Neurosurg Focus. 2012 Aug; 33(2):E7.
    View in: PubMed
  33. Gross BA, Dunn IF, Du R, Al-Mefty O. Petrosal approaches to brainstem cavernous malformations. Neurosurg Focus. 2012 Aug; 33(2):E10.
    View in: PubMed
  34. Gross BA, Tavanaiepour D, Du R, Al-Mefty O, Dunn IF. Petrosal approaches to posterior circulation aneurysms. Neurosurg Focus. 2012 Aug; 33(2):E9.
    View in: PubMed
  35. Gross BA, Du R. Rate of re-bleeding of arteriovenous malformations in the first year after rupture. J Clin Neurosci. 2012 Aug; 19(8):1087-8.
    View in: PubMed
  36. Gross BA, Frerichs KU, Du R. Sensitivity of CT angiography, T2-weighted MRI, and magnetic resonance angiography in detecting cerebral arteriovenous malformations and associated aneurysms. J Clin Neurosci. 2012 Aug; 19(8):1093-5.
    View in: PubMed
  37. Gross BA, Du R. STA-MCA bypass. Acta Neurochir (Wien). 2012 Aug; 154(8):1463-7.
    View in: PubMed
  38. Wang H, Du R, Stary J, Gkogkas C, Kim D, Day A, Frerichs K. Dissecting aneurysms of the posterior cerebral artery: current endovascular/surgical evaluation and treatment strategies. Neurosurgery. 2012 Jun; 70(6):1581-8; discussion 1588.
    View in: PubMed
  39. Lin N, Zenonos G, Kim AH, Nalbach SV, Du R, Frerichs KU, Friedlander RM, Gormley WB. Angiogram-negative subarachnoid hemorrhage: relationship between bleeding pattern and clinical outcome. Neurocrit Care. 2012 Jun; 16(3):389-98.
    View in: PubMed
  40. Gross BA, Du R. Surgical and radiosurgical results of the treatment of cerebral arteriovenous malformations. J Clin Neurosci. 2012 Jul; 19(7):1001-4.
    View in: PubMed
  41. Gross BA, Lin N, Frerichs KU, Du R. Vasospasm after spontaneous angiographically negative subarachnoid hemorrhage. Acta Neurochir (Wien). 2012 Jul; 154(7):1127-33.
    View in: PubMed
  42. Gross BA, Ropper AE, Du R. Cerebral dural arteriovenous fistulas and aneurysms. Neurosurg Focus. 2012 May; 32(5):E2.
    View in: PubMed
  43. Ropper AE, Lin N, Gross BA, Zarzour HK, Thiex R, Chi JH, Du R, Frerichs KU. Rotational angiography for diagnosis and surgical planning in the management of spinal vascular lesions. Neurosurg Focus. 2012 May; 32(5):E6.
    View in: PubMed
  44. Ropper AE, Gross BA, Du R. Surgical treatment of Type I spinal dural arteriovenous fistulas. Neurosurg Focus. 2012 May; 32(5):E3.
    View in: PubMed
  45. Gross BA, Ropper AE, Popp AJ, Du R. Stereotactic radiosurgery for cerebral dural arteriovenous fistulas. Neurosurg Focus. 2012 May; 32(5):E18.
    View in: PubMed
  46. Li M, Akhavan-Sharif RM, Friedlander RM, Du R, Thiex R. What sequences on high-field MR best depict temporal resolution of experimental ICH and edema formation in mice? J Biomed Biotechnol. 2012; 2012:961461.
    View in: PubMed
  47. Gross BA, Ropper AE, Du R. Association of mesial temporal sclerosis and moyamoya syndrome. Clin Neurol Neurosurg. 2013 Jan; 115(1):106-7.
    View in: PubMed
  48. Gross BA, Batjer HH, Awad IA, Bendok BR, Du R. Brainstem cavernous malformations: 1390 surgical cases from the literature. World Neurosurg. 2013 Jul-Aug; 80(1-2):89-93.
    View in: PubMed
  49. Duan QL, Du R, Lasky-Su J, Klanderman BJ, Partch AB, Peters SP, Irvin CG, Hanrahan JP, Lima JJ, Blake KV, Liggett SB, Litonjua AA, Tantisira KG. A polymorphism in the thyroid hormone receptor gene is associated with bronchodilator response in asthmatics. Pharmacogenomics J. 2013 Apr; 13(2):130-6.
    View in: PubMed
  50. Li M, Akhavan-Sharif RM, Friedlander RM, Du R, and Thiex R. J Biomed Biotechnol. What sequences on high-field MR best depict temporal resolution of experimental ICH and edema formation in mice. 2012; 2012:961461.
  51. Gross BA, Du R. Vasospasm after arteriovenous malformation rupture. World Neurosurg. 2012 Sep-Oct; 78(3-4):300-5.
    View in: PubMed
  52. Chou SH, Feske SK, Simmons SL, Konigsberg RG, Orzell SC, Marckmann A, Bourget G, Bauer DJ, De Jager PL, Du R, Arai K, Lo EH, Ning MM. Elevated peripheral neutrophils and matrix metalloproteinase 9 as biomarkers of functional outcome following subarachnoid hemorrhage. Transl Stroke Res. 2011 Dec; 2(4):600-7.
    View in: PubMed
  53. Hanak BW, Zada G, Nayar VV, Thiex R, Du R, Day AL, Laws ER. Cerebral aneurysms with intrasellar extension: a systematic review of clinical, anatomical, and treatment characteristics. J Neurosurg. 2012 Jan; 116(1):164-78.
    View in: PubMed
  54. Du R, Litonjua AA, Tantisira KG, Lasky-Su J, Sunyaev SR, Klanderman BJ, Celedón JC, Avila L, Soto-Quiros ME, Weiss ST. Genome-wide association study reveals class I MHC-restricted T cell-associated molecule gene (CRTAM) variants interact with vitamin D levels to affect asthma exacerbations. J Allergy Clin Immunol. 2012 Feb; 129(2):368-73, 373.e1-5.
    View in: PubMed
  55. Gross BA, Lin N, Du R, Day AL. The natural history of intracranial cavernous malformations. Neurosurg Focus. 2011 Jun; 30(6):E24.
    View in: PubMed
  56. Zada G, Du R, Laws ER. Defining the "edge of the envelope": patient selection in treating complex sellar-based neoplasms via transsphenoidal versus open craniotomy. J Neurosurg. 2011 Feb; 114(2):286-300.
    View in: PubMed
  57. Gross BA, Du R, Popp AJ, Day AL. Intramedullary spinal cord cavernous malformations. Neurosurg Focus. 2010 Sep; 29(3):E14.
    View in: PubMed
  58. Du R, Auguste KI, Chin CT, Engstrom JW, Weinstein PR. Magnetic resonance neurography for the evaluation of peripheral nerve, brachial plexus, and nerve root disorders. J Neurosurg. 2010 Feb; 112(2):362-71.
    View in: PubMed
  59. Gross B and Du R. Schmidek & Sweet Operative Neurosurgical Techniques: Indications, Methods, and Results. Quinones-Hinojosa A (Ed.). Intracranial Aneurysms Caused by Infection. 2010.
  60. Du R, Tantisira K, Carey V, Bhattacharya S, Metje S, Kho AT, Klanderman BJ, Gaedigk R, Lazarus R, Mariani TJ, Leeder JS, Weiss ST. Platform dependence of inference on gene-wise and gene-set involvement in human lung development. BMC Bioinformatics. 2009; 10:189.
    View in: PubMed
  61. Du R and Day AL. Youman’s Neurological Surgery. Winn HR (Ed.). Microsurgery of Paraclinoid Aneurysms. 2009.
  62. Du R, Petritsch C, Lu K, Liu P, Haller A, Ganss R, Song H, Vandenberg S, Bergers G. Matrix metalloproteinase-2 regulates vascular patterning and growth affecting tumor cell survival and invasion in GBM. Neuro Oncol. 2008 Jun; 10(3):254-64.
    View in: PubMed
  63. Du R, Lu KV, Petritsch C, Liu P, Ganss R, Passegué E, Song H, Vandenberg S, Johnson RS, Werb Z, Bergers G. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell. 2008 Mar; 13(3):206-20.
    View in: PubMed
  64. Du R and Lee C. Essentials of Neuroanesthesia and Neurointensive Care. Gelb A and Gupta AK (Eds.). Surgical Positioning. 2008.
  65. Du R and McDermott M. Essentials of Neuroanesthesia and Neurointensive Care. Gelb A and Gupta AK (Eds.). Surgical Approaches. 2008.
  66. Day AL, Du R and Maher, CO. Neurosurgical Operative Atlas 2E: Vascular Neurosurgery. Macdonald RL (Ed.). Ophthalmic Segment Aneurysms. 2008.
  67. Du R, Keyoung HM, Dowd CF, Young WL, Lawton MT. The effects of diffuseness and deep perforating artery supply on outcomes after microsurgical resection of brain arteriovenous malformations. Neurosurgery. 2007 Apr; 60(4):638-46; discussion 646-8.
    View in: PubMed
  68. Du R, Hashimoto T, Tihan T, Young WL, Perry V, Lawton MT. Growth and regression of arteriovenous malformations in a patient with hereditary hemorrhagic telangiectasia. Case report. J Neurosurg. 2007 Mar; 106(3):470-7.
    View in: PubMed
  69. Du R and Friedlander RM. Neurosurgery. Wall shear stress gradient analysis within an idealized stenosis using non-newtonian flow – Comments. 2007; 61:863-864.
  70. Du R and Friedlander RM. Neurosurgery. An arteriovenous malformation model for stereotactic radiosurgery research – Comments. 2007; 61:159.
  71. Zhu Y, Lawton MT, Du R, Shwe Y, Chen Y, Shen F, Young WL, Yang GY. Expression of hypoxia-inducible factor-1 and vascular endothelial growth factor in response to venous hypertension. Neurosurgery. 2006 Sep; 59(3):687-96; discussion 687-96.
    View in: PubMed
  72. Zhu Y, Shwe Y, Du R, Chen Y, Shen FX, Young WL, Yang GY. Effects of angiopoietin-1 on vascular endothelial growth factor-induced angiogenesis in the mouse brain. Acta Neurochir Suppl. 2006; 96:438-43.
    View in: PubMed
  73. Day AL and Du R. Journal Watch. Risk models help predict complications of carotid endarterectomy. 2006.
  74. Du R, Dowd CF, Johnston SC, Young WL, Lawton MT. Interobserver variability in grading of brain arteriovenous malformations using the Spetzler-Martin system. Neurosurgery. 2005 Oct; 57(4):668-75; discussion 668-75.
    View in: PubMed
  75. Du R, Meeker M, Bacchetti P, Larson MD, Holland MC, Manley GT. Evaluation of the portable infrared pupillometer. Neurosurgery. 2005 Jul; 57(1):198-203; discussion 198-203.
    View in: PubMed
  76. Lawton MT, Du R. Effect of the neurosurgeon's surgical experience on outcomes from intraoperative aneurysmal rupture. Neurosurgery. 2005 Jul; 57(1):9-15; discussion 9-15.
    View in: PubMed
  77. Zhu Y, Lee C, Shen F, Du R, Young WL, Yang GY. Angiopoietin-2 facilitates vascular endothelial growth factor-induced angiogenesis in the mature mouse brain. Stroke. 2005 Jul; 36(7):1533-7.
    View in: PubMed
  78. Quiñones-Hinojosa A, Du R, Lawton MT. Revascularization with saphenous vein bypasses for complex intracranial aneurysms. Skull Base. 2005 May; 15(2):119-32.
    View in: PubMed
  79. Quiñones-Hinojosa A, Lyon R, Du R, Lawton MT. Intraoperative motor mapping of the cerebral peduncle during resection of a midbrain cavernous malformation: technical case report. Neurosurgery. 2005 Apr; 56(2 Suppl):E439; discussion E439.
    View in: PubMed
  80. Lawton MT, Du R, Tran MN, Achrol AS, McCulloch CE, Johnston SC, Quinnine NJ, Young WL. Effect of presenting hemorrhage on outcome after microsurgical resection of brain arteriovenous malformations. Neurosurgery. 2005 Mar; 56(3):485-93; discussion 485-93.
    View in: PubMed
  81. Meeker M, Du R, Bacchetti P, Privitera CM, Larson MD, Holland MC, Manley G. Pupil examination: validity and clinical utility of an automated pupillometer. J Neurosci Nurs. 2005 Feb; 37(1):34-40.
    View in: PubMed
  82. Du R, McDermott MW, Dowd CF, Young WL, Lawton MT. Neurosurgery at the crossroads: integrated multidisciplinary management of 449 patients with brain arteriovenous malformations. Clin Neurosurg. 2005; 52:177-91.
    View in: PubMed
  83. Du R, Young WL, Lawton MT. "Tangential" resection of medial temporal lobe arteriovenous malformations with the orbitozygomatic approach. Neurosurgery. 2004 Mar; 54(3):645-51; discussion 651-2.
    View in: PubMed
  84. Du R, McDermott MW, Gupta N. Textbook of Neuro-Oncology. Berger MS and Prados MD (Eds.). Craniopharyngiomas. 2004.
  85. Du R, Lustig RH, Fisch B, McDermott MW. Pediatric CNS Tumors. Gupta N, Banerjee A, Haas-Kogan D (Eds.). Craniopharyngioma. 2004.
  86. Du R and Parsa AT. Neurosurgery’s Science Times. Astrocytes and cerebral blood flow. 2004; 55:N7.
  87. Du R, Binder DK, Halbach V, Fischbein N, Barbaro NM. Trigeminal neuralgia in a patient with a dural arteriovenous fistula in Meckel's cave: case report. Neurosurgery. 2003 Jul; 53(1):216-21; discussion 221.
    View in: PubMed
  88. Du R, Dhoot J, McDermott MW, Gupta N. Cystic schwannoma of the anterior tentorial hiatus. Case report and review of the literature. Pediatr Neurosurg. 2003 Apr; 38(4):167-73.
    View in: PubMed
  89. Binder D, Schmidt M, Du R, Berger M. Biomedical Photonics Handbook. 2001.
  90. Enoki T, Tanaka K, Watanabe T, Oya T, Sakiyama T, Takeoka Y, Ito K, Wang G, Annaka M, Hara K, Du R, Chuang J, Wasserman K, Grosberg A, Masamune S, and Tanaka T. Phys Rev Lett. Frustrations in polymer conformation in gels and their minimization through molecular imprinting. 2000; 85:5000-5003.
  91. Du R, Grosberg AY, Tanaka T, and Rubenstein M. Phys Rev Lett. Unexpected scenario of glass transition in polymer globules: an exactly enumerable model. 2000; 84:2417-2420.
  92. Du R, Grosberg AY, and Tanaka T. Phys Rev Lett. Random walks in the space of conformations of toy proteins. 2000; 84:1828-1831.
  93. Du R, Pande VS, Grosberg AY, Tanaka T, and Shakhnovich E. J Chem Phys. On the role of conformational geometry in protein folding. 1999; 111:10375-10380.
  94. Du R, Grosberg AY, and Tanaka T. Phys Rev Lett. Coexistence of native and denatured phases in a single protein-like molecule. 1999; 83:4670-4673.
  95. Du R. On the Kinetics and Thermodynamics of Disordered Heteropolymers. 1999.
  96. Takeoka Y, Berker A, Du R, Enoki T, Grosberg A, Kardar M, Oya T, Tanaka K, Wang G, Yu X, and Tanaka T. Phys Rev Lett. First order phase transition and evidence for frustrations in polyampholytic gels. 1999; 82:4863-4865.
  97. Du R, Pande VS, Grosberg AY, Tanaka T, and Shakhnovich EI. J Chem Phys. On the transition coordinate of protein folding. 1998; 108:334-350.
  98. Du R, Grosberg AY, and Tanaka T. Folding & Design. Models of protein interactions: how to choose one. 1998; 3:203-211.
  99. Du R and Stone HA. Phys Rev E. Evaporatively-controlled growth of salt trees. 1996; 53:1994-1997.
  100. Pinfold JL, Du R, Kinoshita K, Lorazo B, Price B, and Regimbald M. Phys Lett B. A search for highly ionizing particles produced at the OPAL intersection point at LEP. 1993; 316:407-411.
  101. Kinoshita K, Du R, Giacomelli G, Patrizii L, Predieri F, Serra P, Spurio M, and Pinfold JL. Phys Rev D. Search for highly ionizing particles in e+e- annihilations at s^1/2=91.1 GeV. 1992; 46:R881-R884.
  102. Du R and Mattar F. Fourth International Laser Science Conference. Cross-phase Modulation and Cross-focusing Effects in Optical Fibers. 1989; 198-206.
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