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Raj K. Goyal, M.D., M.B.,B.S.

TitleMallinckrodt Professor of Medicine
InstitutionVeterans Affairs Boston Healthcare System
DepartmentMedicine
AddressBrockton W Roxbury, VA Med Ctr
Orea 2B119 (151)
1400 VFW Pkwy
West Roxbury MA 02132
Phone857/203-5612
Fax857/203-5592

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. He XD, Goyal RK. CaMKII inhibition hyperpolarizes membrane and blocks nitrergic IJP by closing a Cl(-) conductance in intestinal smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2012 Jul 15; 303(2):G240-6.
    View in: PubMed
  2. Chaudhury A, He XD, Goyal RK. Role of myosin Va in purinergic vesicular neurotransmission in the gut. Am J Physiol Gastrointest Liver Physiol. 2012 Mar 15; 302(6):G598-607.
    View in: PubMed
  3. Goyal RK. Evidence for ß-nicotinamide adenine dinucleotide as a purinergic, inhibitory neurotransmitter in doubt. Gastroenterology. 2011 Oct; 141(4):e27; author reply e27-8.
    View in: PubMed
  4. Chaudhury A, He XD, Goyal RK. Myosin Va plays a key role in nitrergic neurotransmission by transporting nNOSa to enteric varicosity membrane. Am J Physiol Gastrointest Liver Physiol. 2011 Sep; 301(3):G498-507.
    View in: PubMed
  5. Pal J, Bertheau R, Buon L, Qazi A, Batchu RB, Bandyopadhyay S, Ali-Fehmi R, Beer DG, Weaver DW, Shmookler Reis RJ, Goyal RK, Huang Q, Munshi NC, Shammas MA. Genomic evolution in Barrett's adenocarcinoma cells: critical roles of elevated hsRAD51, homologous recombination and Alu sequences in the genome. Oncogene. 2011 Aug 18; 30(33):3585-98.
    View in: PubMed
  6. Qazi A, Pal J, Maitah M, Fulciniti M, Pelluru D, Nanjappa P, Lee S, Batchu RB, Prasad M, Bryant CS, Rajput S, Gryaznov S, Beer DG, Weaver DW, Munshi NC, Goyal RK, Shammas MA. Anticancer activity of a broccoli derivative, sulforaphane, in barrett adenocarcinoma: potential use in chemoprevention and as adjuvant in chemotherapy. Transl Oncol. 2010; 3(6):389-99.
    View in: PubMed
  7. Goyal RK, Chaudhury A. Pathogenesis of achalasia: lessons from mutant mice. Gastroenterology. 2010 Oct; 139(4):1086-90.
    View in: PubMed
  8. Goyal RK, Chaudhury A. Mounting evidence against the role of ICC in neurotransmission to smooth muscle in the gut. Am J Physiol Gastrointest Liver Physiol. 2010 Jan; 298(1):G10-3.
    View in: PubMed
  9. Chaudhury A, He XD, Goyal RK. Role of PSD95 in membrane association and catalytic activity of nNOSalpha in nitrergic varicosities in mice gut. Am J Physiol Gastrointest Liver Physiol. 2009 Oct; 297(4):G806-13.
    View in: PubMed
  10. Thatte HS, He XD, Goyal RK. Imaging of nitric oxide in nitrergic neuromuscular neurotransmission in the gut. PLoS One. 2009; 4(4):e4990.
    View in: PubMed
  11. Liu W, Hahn H, Odze RD, Goyal RK. Metaplastic esophageal columnar epithelium without goblet cells shows DNA content abnormalities similar to goblet cell-containing epithelium. Am J Gastroenterol. 2009 Apr; 104(4):816-24.
    View in: PubMed
  12. Zhang X, Huang Q, Goyal RK, Odze RD. DNA ploidy abnormalities in basal and superficial regions of the crypts in Barrett's esophagus and associated neoplastic lesions. Am J Surg Pathol. 2008 Sep; 32(9):1327-35.
    View in: PubMed
  13. Shammas MA, Qazi A, Batchu RB, Bertheau RC, Wong JY, Rao MY, Prasad M, Chanda D, Ponnazhagan S, Anderson KC, Steffes CP, Munshi NC, De Vivo I, Beer DG, Gryaznov S, Weaver DW, Goyal RK. Telomere maintenance in laser capture microdissection-purified Barrett's adenocarcinoma cells and effect of telomerase inhibition in vivo. Clin Cancer Res. 2008 Aug 1; 14(15):4971-80.
    View in: PubMed
  14. Chaudhury A, Rao YM, Goyal RK. PIN/LC8 is associated with cytosolic but not membrane-bound nNOS in the nitrergic varicosities of mice gut: implications for nitrergic neurotransmission. Am J Physiol Gastrointest Liver Physiol. 2008 Sep; 295(3):G442-51.
    View in: PubMed
  15. Sivarao DV, Mashimo H, Goyal RK. Pyloric sphincter dysfunction in nNOS-/- and W/Wv mutant mice: animal models of gastroparesis and duodenogastric reflux. Gastroenterology. 2008 Oct; 135(4):1258-66.
    View in: PubMed
  16. Huang Q, Yu C, Zhang X, Goyal RK. Comparison of DNA histograms by standard flow cytometry and image cytometry on sections in Barrett's adenocarcinoma. BMC Clin Pathol. 2008; 8:5.
    View in: PubMed
  17. Goyal RK, Chaudhury A. Physiology of normal esophageal motility. J Clin Gastroenterol. 2008 May-Jun; 42(5):610-9.
    View in: PubMed
  18. Rao YM, Chaudhury A, Goyal RK. Active and inactive pools of nNOS in the nerve terminals in mouse gut: implications for nitrergic neurotransmission. Am J Physiol Gastrointest Liver Physiol. 2008 Mar; 294(3):G627-34.
    View in: PubMed
  19. Hornick JL, Mino-Kenudson M, Lauwers GY, Liu W, Goyal R, Odze RD. Buried Barrett's epithelium following photodynamic therapy shows reduced crypt proliferation and absence of DNA content abnormalities. Am J Gastroenterol. 2008 Jan; 103(1):38-47.
    View in: PubMed
  20. Yu C, Zhang X, Huang Q, Klein M, Goyal RK. High-fidelity DNA histograms in neoplastic progression in Barrett's esophagus. Lab Invest. 2007 May; 87(5):466-72.
    View in: PubMed
  21. Shammas MA, Neri P, Koley H, Batchu RB, Bertheau RC, Munshi V, Prabhala R, Fulciniti M, Tai YT, Treon SP, Goyal RK, Anderson KC, Munshi NC. Specific killing of multiple myeloma cells by (-)-epigallocatechin-3-gallate extracted from green tea: biologic activity and therapeutic implications. Blood. 2006 Oct 15; 108(8):2804-10.
    View in: PubMed
  22. Huang Q, Yu C, Klein M, Fang J, Goyal RK. DNA index determination with Automated Cellular Imaging System (ACIS) in Barrett's esophagus: comparison with CAS 200. BMC Clin Pathol. 2005 Aug 12; 5:7.
    View in: PubMed
  23. Shammas MA, Koley H, Batchu RB, Bertheau RC, Protopopov A, Munshi NC, Goyal RK. Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential. Mol Cancer. 2005; 4:24.
    View in: PubMed
  24. Mashimo H, Wagh MS, Goyal RK. Surveillance and screening for Barrett esophagus and adenocarcinoma. J Clin Gastroenterol. 2005 Apr; 39(4 Suppl 2):S33-41.
    View in: PubMed
  25. Fang M, Lew E, Klein M, Sebo T, Su Y, Goyal R. DNA abnormalities as marker of risk for progression of Barrett's esophagus to adenocarcinoma: image cytometric DNA analysis in formalin-fixed tissues. Am J Gastroenterol. 2004 Oct; 99(10):1887-94.
    View in: PubMed
  26. Su Y, Chen X, Klein M, Fang M, Wang S, Yang CS, Goyal RK. Phenotype of columnar-lined esophagus in rats with esophagogastroduodenal anastomosis: similarity to human Barrett's esophagus. Lab Invest. 2004 Jun; 84(6):753-65.
    View in: PubMed
  27. Shammas MA, Koley H, Beer DG, Li C, Goyal RK, Munshi NC. Growth arrest, apoptosis, and telomere shortening of Barrett's-associated adenocarcinoma cells by a telomerase inhibitor. Gastroenterology. 2004 May; 126(5):1337-46.
    View in: PubMed
  28. Prasad M, Goyal RK. Differential modulation of voltage-dependent K+ currents in colonic smooth muscle by oxidants. Am J Physiol Cell Physiol. 2004 Mar; 286(3):C671-82.
    View in: PubMed
  29. Shammas MA, Shmookler Reis RJ, Akiyama M, Koley H, Chauhan D, Hideshima T, Goyal RK, Hurley LH, Anderson KC, Munshi NC. Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma. Mol Cancer Ther. 2003 Sep; 2(9):825-33.
    View in: PubMed
  30. Prasad M, Goyal RK. Monochloramine selectively inhibits the transient outward potassium current in colonic smooth muscle. Surgery. 2003 Aug; 134(2):319-28.
    View in: PubMed
  31. Chang HY, Mashimo H, Goyal RK. Musings on the wanderer: what's new in our understanding of vago-vagal reflex? IV. Current concepts of vagal efferent projections to the gut. Am J Physiol Gastrointest Liver Physiol. 2003 Mar; 284(3):G357-66.
    View in: PubMed
  32. Szymanski PT, Szymanska G, Goyal RK. Differences in calmodulin and calmodulin-binding proteins in phasic and tonic smooth muscles. Am J Physiol Cell Physiol. 2002 Jan; 282(1):C94-C104.
    View in: PubMed
  33. Goyal RK, Padmanabhan R, Sang Q. Neural circuits in swallowing and abdominal vagal afferent-mediated lower esophageal sphincter relaxation. Am J Med. 2001 Dec 3; 111 Suppl 8A:95S-105S.
    View in: PubMed
  34. Sivarao DV, Mashimo HL, Thatte HS, Goyal RK. Lower esophageal sphincter is achalasic in nNOS(-/-) and hypotensive in W/W(v) mutant mice. Gastroenterology. 2001 Jul; 121(1):34-42.
    View in: PubMed
  35. Sang Q, Goyal RK. Swallowing reflex and brain stem neurons activated by superior laryngeal nerve stimulation in the mouse. Am J Physiol Gastrointest Liver Physiol. 2001 Feb; 280(2):G191-200.
    View in: PubMed
  36. Glickman JN, Wang H, Das KM, Goyal RK, Spechler SJ, Antonioli D, Odze RD. Phenotype of Barrett's esophagus and intestinal metaplasia of the distal esophagus and gastroesophageal junction: an immunohistochemical study of cytokeratins 7 and 20, Das-1 and 45 MI. Am J Surg Pathol. 2001 Jan; 25(1):87-94.
    View in: PubMed
  37. Goyal RK. Targets of enteric motor neurones: smooth muscle cells. Gut. 2000 Dec; 47 Suppl 4:iv38-9; discussion iv52.
    View in: PubMed
  38. Sang Q, Goyal RK. Lower esophageal sphincter relaxation and activation of medullary neurons by subdiaphragmatic vagal stimulation in the mouse. Gastroenterology. 2000 Dec; 119(6):1600-9.
    View in: PubMed
  39. Yamato S, Hirano I, Goyal RK. Effect of galanin and galanin antagonists on peristalsis in esophageal smooth muscle in the opossum. Am J Physiol Gastrointest Liver Physiol. 2000 Oct; 279(4):G719-25.
    View in: PubMed
  40. Mashimo H, Kjellin A, Goyal RK. Gastric stasis in neuronal nitric oxide synthase-deficient knockout mice. Gastroenterology. 2000 Sep; 119(3):766-73.
    View in: PubMed
  41. Sivarao DV, Goyal RK. Functional anatomy and physiology of the upper esophageal sphincter. Am J Med. 2000 Mar 6; 108 Suppl 4a:27S-37S.
    View in: PubMed
  42. Akbarali HI, Thatte H, He XD, Giles WR, Goyal RK. Role of HERG-like K(+) currents in opossum esophageal circular smooth muscle. Am J Physiol. 1999 Dec; 277(6 Pt 1):C1284-90.
    View in: PubMed
  43. Chen YY, Wang HH, Antonioli DA, Spechler SJ, Zeroogian JM, Goyal R, Shahsafaei A, Odze RD. Significance of acid-mucin-positive nongoblet columnar cells in the distal esophagus and gastroesophageal junction. Hum Pathol. 1999 Dec; 30(12):1488-95.
    View in: PubMed
  44. Gulizia JM, Wang H, Antonioli D, Spechler SJ, Zeroogian J, Goyal R, Shahsafaei A, Chen YY, Odze RD. Proliferative characteristics of intestinalized mucosa in the distal esophagus and gastroesophageal junction (short-segment Barrett's esophagus): a case control study. Hum Pathol. 1999 Apr; 30(4):412-8.
    View in: PubMed
  45. Szymanski PT, Goyal RK. Calponin binds to the 20-kilodalton regulatory light chain of myosin. Biochemistry. 1999 Mar 23; 38(12):3778-84.
    View in: PubMed
  46. Goyal RK, He XD. Evidence for NO. redox form of nitric oxide as nitrergic inhibitory neurotransmitter in gut. Am J Physiol. 1998 Nov; 275(5 Pt 1):G1185-92.
    View in: PubMed
  47. Chen YY, Antonioli DA, Spechler SJ, Zeroogian JM, Goyal RK, Wang HH. Gastroesophageal reflux disease versus Helicobacter pylori infection as the cause of gastric carditis. Mod Pathol. 1998 Oct; 11(10):950-6.
    View in: PubMed
  48. Szymanski PT, Chacko TK, Rovner AS, Goyal RK. Differences in contractile protein content and isoforms in phasic and tonic smooth muscles. Am J Physiol. 1998 Sep; 275(3 Pt 1):C684-92.
    View in: PubMed
  49. Vogalis F, Zhang Y, Goyal RK. An intermediate conductance K+ channel in the cell membrane of mouse intestinal smooth muscle. Biochim Biophys Acta. 1998 May 28; 1371(2):309-16.
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  50. Wang HH, Sovie S, Zeroogian JM, Spechler SJ, Goyal RK, Antonioli DA. Value of cytology in detecting intestinal metaplasia and associated dysplasia at the gastroesophageal junction. Hum Pathol. 1997 Apr; 28(4):465-71.
    View in: PubMed
  51. Wang HH, Zeroogian JM, Spechler SJ, Goyal RK, Antonioli DA. Prevalence and significance of pancreatic acinar metaplasia at the gastroesophageal junction. Am J Surg Pathol. 1996 Dec; 20(12):1507-10.
    View in: PubMed
  52. Wang Q, Akbarali HI, Hatakeyama N, Goyal RK. Caffeine- and carbachol-induced Cl- and cation currents in single opossum esophageal circular muscle cells. Am J Physiol. 1996 Nov; 271(5 Pt 1):C1725-34.
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  53. Mashimo H, He XD, Huang PL, Fishman MC, Goyal RK. Neuronal constitutive nitric oxide synthase is involved in murine enteric inhibitory neurotransmission. J Clin Invest. 1996 Jul 1; 98(1):8-13.
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  54. Hatakeyama N, Mukhopadhyay D, Goyal RK, Akbarali HI. Tyrosine kinase-dependent modulation of calcium entry in rabbit colonic muscularis mucosae. Am J Physiol. 1996 Jun; 270(6 Pt 1):C1780-9.
    View in: PubMed
  55. Shapiro J, Martin S, DeGirolami U, Goyal R. Inflammatory myopathy causing pharyngeal dysphagia: a new entity. Ann Otol Rhinol Laryngol. 1996 May; 105(5):331-5.
    View in: PubMed
  56. Goyal RK, Hirano I. The enteric nervous system. N Engl J Med. 1996 Apr 25; 334(17):1106-15.
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  57. Spechler SJ, Goyal RK. The columnar-lined esophagus, intestinal metaplasia, and Norman Barrett. Gastroenterology. 1996 Feb; 110(2):614-21.
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  58. Spechler SJ, Souza RF, Rosenberg SJ, Ruben RA, Goyal RK. Heartburn in patients with achalasia. Gut. 1995 Sep; 37(3):305-8.
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  59. Akbarali HI, Hatakeyama N, Wang Q, Goyal RK. Transient outward current in opossum esophageal circular muscle. Am J Physiol. 1995 Jun; 268(6 Pt 1):G979-87.
    View in: PubMed
  60. Hatakeyama N, Wang Q, Goyal RK, Akbarali HI. Muscarinic suppression of ATP-sensitive K+ channel in rabbit esophageal smooth muscle. Am J Physiol. 1995 Apr; 268(4 Pt 1):C877-85.
    View in: PubMed
  61. Spechler SJ, Zeroogian JM, Antonioli DA, Wang HH, Goyal RK. Prevalence of metaplasia at the gastro-oesophageal junction. Lancet. 1994 Dec 3; 344(8936):1533-6.
    View in: PubMed
  62. Kobler JB, Datta S, Goyal RK, Benecchi EJ. Innervation of the larynx, pharynx, and upper esophageal sphincter of the rat. J Comp Neurol. 1994 Nov 1; 349(1):129-47.
    View in: PubMed
  63. Akbarali HI, Goyal RK. Effect of sodium nitroprusside on Ca2+ currents in opossum esophageal circular muscle cells. Am J Physiol. 1994 Jun; 266(6 Pt 1):G1036-42.
    View in: PubMed
  64. He XD, Goyal RK. Nitric oxide involvement in the peptide VIP-associated inhibitory junction potential in the guinea-pig ileum. J Physiol. 1993 Feb; 461:485-99.
    View in: PubMed
  65. Goyal RK, Martin SB, Shapiro J, Spechler SJ. The role of cricopharyngeus muscle in pharyngoesophageal disorders. Dysphagia. 1993; 8(3):252-8.
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  66. Sengupta JN, Saha JK, Goyal RK. Differential sensitivity to bradykinin of esophageal distension-sensitive mechanoreceptors in vagal and sympathetic afferents of the opossum. J Neurophysiol. 1992 Oct; 68(4):1053-67.
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  67. Crist JR, He XD, Goyal RK. Both ATP and the peptide VIP are inhibitory neurotransmitters in guinea-pig ileum circular muscle. J Physiol. 1992 Feb; 447:119-31.
    View in: PubMed
  68. Crist JR, He XD, Goyal RK. Chloride-mediated junction potentials in circular muscle of the guinea pig ileum. Am J Physiol. 1991 Nov; 261(5 Pt 1):G742-51.
    View in: PubMed
  69. Singaram C, Sengupta A, Sugarbaker DJ, Goyal RK. Peptidergic innervation of the human esophageal smooth muscle. Gastroenterology. 1991 Nov; 101(5):1256-63.
    View in: PubMed
  70. Crist JR, He XD, Goyal RK. Chloride-mediated inhibitory junction potentials in opossum esophageal circular smooth muscle. Am J Physiol. 1991 Nov; 261(5 Pt 1):G752-62.
    View in: PubMed
  71. Crist JR, He XD, Goyal RK. The nature of noncholinergic membrane potential responses to transmural stimulation in guinea pig ileum. Gastroenterology. 1991 Apr; 100(4):1006-15.
    View in: PubMed
  72. Singaram C, Sengupta A, Stevens C, Spechler SJ, Goyal RK. Localization of calcitonin gene-related peptide in human esophageal Langerhans cells. Gastroenterology. 1991 Feb; 100(2):560-3.
    View in: PubMed
  73. Sengupta JN, Saha JK, Goyal RK. Stimulus-response function studies of esophageal mechanosensitive nociceptors in sympathetic afferents of opossum. J Neurophysiol. 1990 Sep; 64(3):796-812.
    View in: PubMed
  74. Saha JK, Sengupta JN, Goyal RK. Effect of bradykinin on opossum esophageal longitudinal smooth muscle: evidence for novel bradykinin receptors. J Pharmacol Exp Ther. 1990 Mar; 252(3):1012-20.
    View in: PubMed
  75. Singaram C, Sengupta A, Spechler SJ, Goyal RK. Mucosal peptidergic innervation of the opossum esophagus and anal canal: a comparison with snout skin. J Auton Nerv Syst. 1990 Mar; 29(3):231-40.
    View in: PubMed
  76. Goyal RK. Muscarinic receptor subtypes. Physiology and clinical implications. N Engl J Med. 1989 Oct 12; 321(15):1022-9.
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  77. Sengupta JN, Kauvar D, Goyal RK. Characteristics of vagal esophageal tension-sensitive afferent fibers in the opossum. J Neurophysiol. 1989 May; 61(5):1001-10.
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  78. Paterson WG, Rattan S, Goyal RK. Esophageal responses to transient and sustained esophageal distension. Am J Physiol. 1988 Nov; 255(5 Pt 1):G587-95.
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  79. Goyal RK, Crist JR. Chest pain of esophageal etiology. Hosp Pract (Off Ed). 1988 Sep 30; 23(9A):15-20.
    View in: PubMed
  80. Rattan S, Gonnella P, Goyal RK. Inhibitory effect of calcitonin gene-related peptide and calcitonin on opossum esophageal smooth muscle. Gastroenterology. 1988 Feb; 94(2):284-93.
    View in: PubMed
  81. Sengupta A, Goyal RK. Localization of galanin immunoreactivity in the opossum esophagus. J Auton Nerv Syst. 1988 Feb; 22(1):49-56.
    View in: PubMed
  82. Goyal RK. Identification, localization and classification of muscarinic receptor subtypes in the gut. Life Sci. 1988; 43(26):2209-20.
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  83. Rattan S, Goyal RK. Effect of galanin on the opossum lower esophageal sphincter. Life Sci. 1987 Dec 28; 41(26):2783-90.
    View in: PubMed
  84. Paull A, Trier JS, Dalton MD, Camp RC, Loeb P, Goyal RK. The histologic spectrum of Barrett's esophagus. N Engl J Med. 1976 Aug 26; 295(9):476-80.
    View in: PubMed
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