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Collin Melveton Stultz, M.D.,PH.D.

TitleMember of the Faculty of Health Sciences and Technology
InstitutionMassachusetts Institute of Technology
DepartmentHealth Sciences and Technology
AddressMass Institute Of Technology
Mit 36-796
77 Massachusetts Ave
Cambridge MA 02139
Phone617/253-4961
Fax617/324-3644

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Gee EP, Yüksel D, Stultz CM, Ingber DE. SLLISWD Sequence in the 10FNIII Domain Initiates Fibronectin Fibrillogenesis. J Biol Chem. 2013 Jul 19; 288(29):21329-40.
    View in: PubMed
  2. Fisher CK, Ullman O, Stultz CM. Comparative studies of disordered proteins with similar sequences: application to aß40 and aß42. Biophys J. 2013 Apr 2; 104(7):1546-55.
    View in: PubMed
  3. Gurry T, Ullman O, Fisher CK, Perovic I, Pochapsky T, Stultz CM. The Dynamic Structure of a-Synuclein Multimers. J Am Chem Soc. 2013 Mar 13; 135(10):3865-72.
    View in: PubMed
  4. Lu KG, Stultz CM. Insight into the Degradation of Type-I Collagen Fibrils by MMP-8. J Mol Biol. 2013 May 27; 425(10):1815-25.
    View in: PubMed
  5. Liu JS, Schubert CR, Fu X, Fourniol FJ, Jaiswal JK, Houdusse A, Stultz CM, Moores CA, Walsh CA. Molecular basis for specific regulation of neuronal kinesin-3 motors by doublecortin family proteins. Mol Cell. 2012 Sep 14; 47(5):707-21.
    View in: PubMed
  6. Walker S, Ullman O, Stultz CM. Using intramolecular disulfide bonds in tau protein to deduce structural features of aggregation-resistant conformations. J Biol Chem. 2012 Mar 16; 287(12):9591-600.
    View in: PubMed
  7. Fisher CK, Ullman O, Stultz CM. Efficient construction of disordered protein ensembles in a bayesian framework with optimal selection of conformations. Pac Symp Biocomput. 2012; 82-93.
    View in: PubMed
  8. Ullman O, Fisher CK, Stultz CM. Explaining the structural plasticity of a-synuclein. J Am Chem Soc. 2011 Dec 7; 133(48):19536-46.
    View in: PubMed
  9. Syed Z, Stultz CM, Scirica BM, Guttag JV. Computationally generated cardiac biomarkers for risk stratification after acute coronary syndrome. Sci Transl Med. 2011 Sep 28; 3(102):102ra95.
    View in: PubMed
  10. Fisher CK, Stultz CM. Protein structure along the order-disorder continuum. J Am Chem Soc. 2011 Jul 6; 133(26):10022-5.
    View in: PubMed
  11. Fisher CK, Stultz CM. Constructing ensembles for intrinsically disordered proteins. Curr Opin Struct Biol. 2011 Jun; 21(3):426-31.
    View in: PubMed
  12. Chen MM, Bartlett AI, Nerenberg PS, Friel CT, Hackenberger CP, Stultz CM, Radford SE, Imperiali B. Perturbing the folding energy landscape of the bacterial immunity protein Im7 by site-specific N-linked glycosylation. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22528-33.
    View in: PubMed
  13. Fisher CK, Huang A, Stultz CM. Modeling intrinsically disordered proteins with bayesian statistics. J Am Chem Soc. 2010 Oct 27; 132(42):14919-27.
    View in: PubMed
  14. Phillips CM, Schreiter ER, Stultz CM, Drennan CL. Structural basis of low-affinity nickel binding to the nickel-responsive transcription factor NikR from Escherichia coli. Biochemistry. 2010 Sep 14; 49(36):7830-8.
    View in: PubMed
  15. Phillips CM, Stultz CM, Drennan CL. Searching for the Nik operon: how a ligand-responsive transcription factor hunts for its DNA binding site. Biochemistry. 2010 Sep 14; 49(36):7757-63.
    View in: PubMed
  16. Gurry T, Nerenberg PS, Stultz CM. The contribution of interchain salt bridges to triple-helical stability in collagen. Biophys J. 2010 Jun 2; 98(11):2634-43.
    View in: PubMed
  17. Salsas-Escat R, Nerenberg PS, Stultz CM. Cleavage site specificity and conformational selection in type I collagen degradation. Biochemistry. 2010 May 18; 49(19):4147-58.
    View in: PubMed
  18. Salsas-Escat R, Stultz CM. Conformational selection and collagenolysis in type III collagen. Proteins. 2010 Feb 1; 78(2):325-35.
    View in: PubMed
  19. Phillips CM, Nerenberg PS, Drennan CL, Stultz CM. Physical basis of metal-binding specificity in Escherichia coli NikR. J Am Chem Soc. 2009 Jul 29; 131(29):10220-8.
    View in: PubMed
  20. Schubert CR, Stultz CM. The multi-copy simultaneous search methodology: a fundamental tool for structure-based drug design. J Comput Aided Mol Des. 2009 Aug; 23(8):475-89.
    View in: PubMed
  21. Huang A, Stultz CM. Finding order within disorder: elucidating the structure of proteins associated with neurodegenerative disease. Future Med Chem. 2009 Jun; 1(3):467-82.
    View in: PubMed
  22. Syed Z, Sung P, Scirica BM, Morrow DA, Stultz CM, Guttag JV. Spectral energy of ECG morphologic differences to predict death. Cardiovasc Eng. 2009 Mar; 9(1):18-26.
    View in: PubMed
  23. Yoon MK, Venkatachalam V, Huang A, Choi BS, Stultz CM, Chou JJ. Residual structure within the disordered C-terminal segment of p21(Waf1/Cip1/Sdi1) and its implications for molecular recognition. Protein Sci. 2009 Feb; 18(2):337-47.
    View in: PubMed
  24. Syed Z, Scirica BM, Mohanavelu S, Sung P, Michelson EL, Cannon CP, Stone PH, Stultz CM, Guttag JV. Relation of death within 90 days of non-ST-elevation acute coronary syndromes to variability in electrocardiographic morphology. Am J Cardiol. 2009 Feb 1; 103(3):307-11.
    View in: PubMed
  25. Huang A, Stultz CM. The effect of a DeltaK280 mutation on the unfolded state of a microtubule-binding repeat in Tau. PLoS Comput Biol. 2008; 4(8):e1000155.
    View in: PubMed
  26. Nerenberg PS, Stultz CM. Differential unfolding of alpha1 and alpha2 chains in type I collagen and collagenolysis. J Mol Biol. 2008 Sep 26; 382(1):246-56.
    View in: PubMed
  27. Gee EP, Ingber DE, Stultz CM. Fibronectin unfolding revisited: modeling cell traction-mediated unfolding of the tenth type-III repeat. PLoS One. 2008; 3(6):e2373.
    View in: PubMed
  28. Nerenberg PS, Salsas-Escat R, Stultz CM. Do collagenases unwind triple-helical collagen before peptide bond hydrolysis? Reinterpreting experimental observations with mathematical models. Proteins. 2008 Mar; 70(4):1154-61.
    View in: PubMed
  29. Nerenberg PS, Salsas-Escat R, Stultz CM. Collagen--a necessary accomplice in the metastatic process. Cancer Genomics Proteomics. 2007 Sep-Oct; 4(5):319-28.
    View in: PubMed
  30. Thomas AH, Edelman ER, Stultz CM. Collagen fragments modulate innate immunity. Exp Biol Med (Maywood). 2007 Mar; 232(3):406-11.
    View in: PubMed
  31. Huang A, Stultz CM. Conformational sampling with implicit solvent models: application to the PHF6 peptide in tau protein. Biophys J. 2007 Jan 1; 92(1):34-45.
    View in: PubMed
  32. Stultz CM. The folding mechanism of collagen-like model peptides explored through detailed molecular simulations. Protein Sci. 2006 Sep; 15(9):2166-77.
    View in: PubMed
  33. Stultz CM. An Assessment of Potential of Mean Force Calculations with Implicit Solvent Models. J. Chem. Phys B. 2004; 108:16525-16532.
  34. Stultz CM, Edelman ER. A structural model that explains the effects of hyperglycemia on collagenolysis. Biophys J. 2003 Oct; 85(4):2198-204.
    View in: PubMed
  35. Stultz CM, Levin AD, Edelman ER. Phosphorylation-induced conformational changes in a mitogen-activated protein kinase substrate. Implications for tyrosine hydroxylase activation. J Biol Chem. 2002 Dec 6; 277(49):47653-61.
    View in: PubMed
  36. Stultz CM. Localized unfolding of collagen explains collagenase cleavage near imino-poor sites. J Mol Biol. 2002 Jun 21; 319(5):997-1003.
    View in: PubMed
  37. Stultz CM, Levin AD, Edelman ER. A Structural Model that Explains the Effects of Hyperglycemia on Collagenolysis. J. Biol. Chem. 2002; 277:47653-47661.
  38. Stultz CM, Karplus M. Dynamic ligand design and combinatorial optimization: designing inhibitors to endothiapepsin. Proteins. 2000 Aug 1; 40(2):258-89.
    View in: PubMed
  39. Stultz CM, Karplus M. Dynamic Ligand Design and Combinatorial Optimization. Proteins, Structure Function and Genetics. 2000; 40:259-289.
  40. Stultz CM, Karplus M. MCSS functionality maps for a flexible protein. Proteins. 1999 Dec 1; 37(4):512-29.
    View in: PubMed
  41. Stultz CM, Karplus M. MCSS Functionality Maps for a Flexible Protein. Proteins, Structure Function and Gentetics. 1999; 37:512-529.
  42. Stultz CM, Karplus M. On the Potential Surface of the Locally Enhanced Sampling Approximation. Journal of Chemical Physics. 1998; 109:8809-8815.
  43. Stultz CM. Studies in Structure Based Drug Design: Ligand Design with a Flexible Protein . 1997.
  44. Stultz CM, Nambudripad R, Lathrop R, White JV . Predicting Protein Structure with Probabilistic Models. Protein Structural Biology in Bio-Medical Research , Vol. 22B of Advances in Molecular and Cell Biology series editor: E. E. Bittar, Guest Editors: N.M. Allewell and C. Woodward. 1997; 447-506.
  45. Stultz CM. Predicting Protein Structure with Probabilistic Models. 1997.
  46. White JV, Stultz CM, Smith TF. Protein classification by stochastic modeling and optimal filtering of amino-acid sequences. Math Biosci. 1994 Jan; 119(1):35-75.
    View in: PubMed
  47. Stultz CM, White JV, Smith TF. Structural analysis based on state-space modeling. Protein Sci. 1993 Mar; 2(3):305-14.
    View in: PubMed
  48. Stultz CM, White JV, Smith TF. Structural Analysis Based on State Space Modeling. Protein Science. 1993; 2:305-314.
  49. Jacques HPJ, Morris C., Cho E., Stultz C., Yue J. , Laurencin C. Bioerodible Polymers: Novel Approaches for use in Bone. Polymer Preprints. 1990; 31:247.
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