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Ghazaleh Sadri-Vakili, Ph.D.

TitleAssistant Professor of Neurology
InstitutionMassachusetts General Hospital
DepartmentNeurology
AddressMass General Hospital
Bldg 114, Room 2200
114 16th Street
Charlestown MA 02129
Phone617/724-1487

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Schmidt HD, McGinty JF, West AE, Sadri-Vakili G. Epigenetics and psychostimulant addiction. Cold Spring Harb Perspect Med. 2013; 3(3).
    View in: PubMed
  2. Vassoler FM, White SL, Schmidt HD, Sadri-Vakili G, Pierce RC. Epigenetic inheritance of a cocaine-resistance phenotype. Nat Neurosci. 2013 Jan; 16(1):42-7.
    View in: PubMed
  3. McFarland KN, Das S, Sun TT, Leyfer D, Xia E, Sangrey GR, Kuhn A, Luthi-Carter R, Clark TW, Sadri-Vakili G, Cha JH. Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease. PLoS One. 2012; 7(7):e41423.
    View in: PubMed
  4. Jia H, Pallos J, Jacques V, Lau A, Tang B, Cooper A, Syed A, Purcell J, Chen Y, Sharma S, Sangrey GR, Darnell SB, Plasterer H, Sadri-Vakili G, Gottesfeld JM, Thompson LM, Rusche JR, Marsh JL, Thomas EA. Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease. Neurobiol Dis. 2012 May; 46(2):351-61.
    View in: PubMed
  5. Ritch JJ, Valencia A, Alexander J, Sapp E, Gatune L, Sangrey GR, Sinha S, Scherber CM, Zeitlin S, Sadri-Vakili G, Irimia D, Difiglia M, Kegel KB. Multiple phenotypes in Huntington disease mouse neural stem cells. Mol Cell Neurosci. 2012 May; 50(1):70-81.
    View in: PubMed
  6. Schmidt HD, Sangrey GR, Darnell SB, Schassburger RL, Cha JH, Pierce RC, Sadri-Vakili G. Increased brain-derived neurotrophic factor (BDNF) expression in the ventral tegmental area during cocaine abstinence is associated with increased histone acetylation at BDNF exon I-containing promoters. J Neurochem. 2012 Jan; 120(2):202-9.
    View in: PubMed
  7. McCarthy DM, Zhang X, Darnell SB, Sangrey GR, Yanagawa Y, Sadri-Vakili G, Bhide PG. Cocaine alters BDNF expression and neuronal migration in the embryonic mouse forebrain. J Neurosci. 2011 Sep 21; 31(38):13400-11.
    View in: PubMed
  8. Sadri-Vakili G, Kumaresan V, Schmidt HD, Famous KR, Chawla P, Vassoler FM, Overland RP, Xia E, Bass CE, Terwilliger EF, Pierce RC, Cha JH. Cocaine-induced chromatin remodeling increases brain-derived neurotrophic factor transcription in the rat medial prefrontal cortex, which alters the reinforcing efficacy of cocaine. J Neurosci. 2010 Sep 1; 30(35):11735-44.
    View in: PubMed
  9. Benn CL, Luthi-Carter R, Kuhn A, Sadri-Vakili G, Blankson KL, Dalai SC, Goldstein DR, Spires TL, Pritchard J, Olson JM, van Dellen A, Hannan AJ, Cha JH. Environmental enrichment reduces neuronal intranuclear inclusion load but has no effect on messenger RNA expression in a mouse model of Huntington disease. J Neuropathol Exp Neurol. 2010 Aug; 69(8):817-27.
    View in: PubMed
  10. Famous KR, Kumaresan V, Sadri-Vakili G, Schmidt HD, Mierke DF, Cha JH, Pierce RC. Phosphorylation-dependent trafficking of GluR2-containing AMPA receptors in the nucleus accumbens plays a critical role in the reinstatement of cocaine seeking. J Neurosci. 2008 Oct 22; 28(43):11061-70.
    View in: PubMed
  11. Benn CL, Sun T, Sadri-Vakili G, McFarland KN, DiRocco DP, Yohrling GJ, Clark TW, Bouzou B, Cha JH. Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner. J Neurosci. 2008 Oct 15; 28(42):10720-33.
    View in: PubMed
  12. Sadri-Vakili G, Janis GC, Pierce RC, Gibbs TT, Farb DH. Nanomolar concentrations of pregnenolone sulfate enhance striatal dopamine overflow in vivo. J Pharmacol Exp Ther. 2008 Dec; 327(3):840-5.
    View in: PubMed
  13. Broom WJ, Greenway M, Sadri-Vakili G, Russ C, Auwarter KE, Glajch KE, Dupre N, Swingler RJ, Purcell S, Hayward C, Sapp PC, McKenna-Yasek D, Valdmanis PN, Bouchard JP, Meininger V, Hosler BA, Glass JD, Polack M, Rouleau GA, Cha JH, Hardiman O, Brown RH. 50bp deletion in the promoter for superoxide dismutase 1 (SOD1) reduces SOD1 expression in vitro and may correlate with increased age of onset of sporadic amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2008 Aug; 9(4):229-37.
    View in: PubMed
  14. Kim MO, Chawla P, Overland RP, Xia E, Sadri-Vakili G, Cha JH. Altered histone monoubiquitylation mediated by mutant huntingtin induces transcriptional dysregulation. J Neurosci. 2008 Apr 9; 28(15):3947-57.
    View in: PubMed
  15. Anderson SM, Famous KR, Sadri-Vakili G, Kumaresan V, Schmidt HD, Bass CE, Terwilliger EF, Cha JH, Pierce RC. CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking. Nat Neurosci. 2008 Mar; 11(3):344-53.
    View in: PubMed
  16. Kim, M., Chawla, P., Overland, R.P., E. Xia, Sadri-Vakili, G., Cha, J.-H.J. Mutant Huntingtin-mediated histone monoubiquitylation induces transcriptional dysregulation in Huntington’s disease. Journal of Neuroscience. 2008; in press.
  17. Broom, W.J., Greenway, M., Sadri-Vakili, G., Russ, C., Auwrter, K.E., Glajch, K.E., Swingler, R.J., Purcell, S., Sapp, P.C., McKenna-Yasek, D., Hosler, B.A., Horvitz, H.R., Glass, J.D., Cha, J.H.J., Hardiman, O., Brown Jr., R.H. 50bp deletion in the promoter for SOD1 promoter reduces SOD1 expression in vitro and correlates with population-specific increased age of onset in sporadic ALS. Amyotrophic Lateral Sclerosis. 2008; in press.
  18. Sadri-Vakili, G. Histones Associated with Downregulated Genes are Hypo-acetylated in Huntington’s Disease Models. 2008.
  19. Benn, C.L. and Sadri-Vakili, G. Misfolded huntingtin protein and implications for transcriptional dysregulation. Protein Misfolding in Biology and Disease. 2008; in press.
  20. Sadri-Vakili G, Bouzou B, Benn CL, Kim MO, Chawla P, Overland RP, Glajch KE, Xia E, Qiu Z, Hersch SM, Clark TW, Yohrling GJ, Cha JH. Histones associated with downregulated genes are hypo-acetylated in Huntington's disease models. Hum Mol Genet. 2007 Jun 1; 16(11):1293-306.
    View in: PubMed
  21. Sadri-Vakili, G., Bouzou, B., Benn, C.L., Kim, M., Chawla, P., Overland, R.P., Glajch, K.E., Xia, E., Qui, Z., Hersch, S.M., Clark, T.W., Yohrling, G.J., Cha, J.-H.J. Histones Associated with Downregulated Genes are Hypo-acetylated in Huntington’s Disease Models. Gordon Conference on CAG triplet repeat disorders. 2007.
  22. Sadri-Vakili, G. Epigenetics of cocaine addiction. 40th Winter Conference on Brain Research. 2007.
  23. Cha, J.-H.J., Bouzou, B., Benn, C.L., Kim, M., Chawla, P., Overland, R.P., Glajch, K.E., Xia, E., Qui, Z., Hersch, S.M., Clark, T.W., Yohrling, G.J., Sadri-Vakili, G. . Histones Associated with Downregulated Genes are Hypo-acetylated in Huntington’s Disease Models. Society for Neuroscience 37th Annual Meeting. 2007.
  24. Famous, K.R., Sadri-Vakili, G., Kumaresan, V., Schmidt, H.D., Cha, J.-H.J., Pierce, R.C. Increased transcription of CaM-KII in the rat medial prefrontal cortex promotes the reinstatement of cocaine-seeking behavior. Society for Neuroscience 37th Annual Meeting. 2007.
  25. Kim, M., Chawla, P., Ovelnand, R.P., Sadri-Vakili, G., Cha, J.-H.J. . Mutant huntingtin mediated histone monoubiquitylation induces transcriptional dysregulation in Huntington’s disease. Society for Neuroscience 37th Annual Meeting. 2007.
  26. Sadri-Vakili, G., Kumaresan, V., Famous, K.R., Overland, R.P., Xia, E., Schmidt, H.D., Pierce, R.C., Cha, J.-H.J. . Epigenetic regulation of cocaine-induced increases in Brain-derived Neurotrophic Factor transcript in the medial Prefrontal Cortex of the rat. Society for Neurosceince 37th Annual Meeting. 2007.
  27. Benn, C.L., Sun, T., Sadri-Vakili, G., Overland, R.P., Vasan, A., DiRocco, D.P., Yohrling, G.J., Clark, T.W., Bouzou, B., Cha, J.-H.J. . Huntingtin modulates transcription, occupies gene promoters in vivo and binds directly to DNA in a polyglutamine dependent manner. Society for Neuroscience 37th Annual Meeting. 2007.
  28. Sadri-Vakili G, Cha JH. Histone deacetylase inhibitors: a novel therapeutic approach to Huntington's disease (complex mechanism of neuronal death). Curr Alzheimer Res. 2006 Sep; 3(4):403-8.
    View in: PubMed
  29. Sadri-Vakili, G., Chawla, P., Glajch, K.E., Overland, R.P., Cha, J.-H.J. . Histones associated with downregulated genes are hypo-acetylated in in vitro models of Huntington’s disease. HD 2006: Changes, Advances, and good news (CAG)n. 2006.
  30. Sadri-Vakili G, Menon AS, Farrell LA, Keller-McGandy CE, Cantuti-Castelvetri I, Standaert DG, Augood SJ, Yohrling GJ, Cha JH. Huntingtin inclusions do not down-regulate specific genes in the R6/2 Huntington's disease mouse. Eur J Neurosci. 2006 Jun; 23(12):3171-5.
    View in: PubMed
  31. Sadri-Vakili G, Cha JH. Mechanisms of disease: Histone modifications in Huntington's disease. Nat Clin Pract Neurol. 2006 Jun; 2(6):330-8.
    View in: PubMed
  32. Chen-Plotkin AS, Sadri-Vakili G, Yohrling GJ, Braveman MW, Benn CL, Glajch KE, DiRocco DP, Farrell LA, Krainc D, Gines S, MacDonald ME, Cha JH. Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease. Neurobiol Dis. 2006 May; 22(2):233-41.
    View in: PubMed
  33. Cha, J.-H.J., Benn, C.L., Chawla, P., Glajch, K.E., Kim, M., Overland, R.P., Sadri-Vakili, G., Sun, T. . Mechanisms of transcriptional dysregulation in Huntington’s disease. Society for Neurosceince 35th Annual Meeting. 2005.
  34. Sadri-Vakili, G., Chawla, P., Glajch, K.E., Overland, R.P., Cha, J.-H.J. . Histone modifications in Huntington’s disease. Society for Neurosceince 35th Annual Meeting,. 2005.
  35. Sadri-Vakili, G., Chawla, P., Glajch, K.E., Overland, R.P., Cha, J.-H.J. . Histone modifications in Huntington’s disease. American Neurological Association 130th Annual Meeting, plenary talk. 2005.
  36. Sadri-Vakili, G., Chawla, P., Glajch, K.E., Overland, R.P., Cha, J.-H.J. Histone modifications in Huntington’s disease. Gordon Research Conference, CAG triplet repeat disorders. 2005.
  37. Sadri-Vakili, G., Farrell, L.A., Penney E.B., Cha, J.-H.J. . Analysis of histone modifications in Huntington’s disease. Society for Neurosceince 34th Annual Meeting,. 2004.
  38. Norflus, F., Chopra, V., Singh, B., Chopra, R., Swindell, K., Fox, J., Sadri-Vakili, G., Farrell, L.A., Cha, J.-H.J., Ryu, H., Ferrante, R.J., Hersch, S.M. . 5-AZA-2’-Deoxycytidine is neuroprotective in N171-82Q and R6/2 Huntington’s disease transgenic mice. HDSA coalition for the cure 8th Annual Meeting,. 2004.
  39. Sadri-Vakili, G., Farrell, L.A., Penney E.B., Cha, J.-H.J. Analysis of histone modifications in Huntington’s disease. HDSA coalition for the cure 8th Annual Meeting,. 2004.
  40. Sadri-Vakili, G., Farrell, L.A., Penney E.B., Cha, J.-H.J. . Analysis of histone modifications in Huntington’s disease. HDF 2004: Changes, Advances, and good news (CAG)n. 2004.
  41. Farb, David H., Sadri-Vakili, Ghazaleh; Pierce, Robert Christopher; Johnson, David W; Gibbs, Terrell T. Neuroactive steroid derivatives and method of use. 2004.
  42. Sadri-Vakili, G., Penney, E.B., Farrell, L.A., Braveman, M.W., Cha, J.-H.J. . Chromatin Immunoprecipitation analysis of histone modificaitons in Huntington’s disease. Society for Neuroscience 33rd Annual Meeting,. 2003.
  43. Sadri-Vakili G, Johnson DW, Janis GC, Gibbs TT, Pierce RC, Farb DH. Inhibition of NMDA-induced striatal dopamine release and behavioral activation by the neuroactive steroid 3alpha-hydroxy-5beta-pregnan-20-one hemisuccinate. J Neurochem. 2003 Jul; 86(1):92-101.
    View in: PubMed
  44. Ghazaleh Sadri-Vakili. Neurosteroids modulate ionotropic glutamate receptor-induced dopamine release and locomotor acticity in the rat. 2003.
  45. Sadri-Vakili, G., Janis, G.C., Gibbs, T.T., Pierce, R.C., and Farb, D.H. . Pregnenolone sulfate increases dopamine release in the rat striatum. Society for Neuroscience 32th Annual Meeting,. 2002.
  46. Sadri-Vakili, G., Janis, G.C., Johnson, D.W., Pierce, R.C., and Farb, D.H. . Inhibition of NMDA-induced striatal dopamine release and behavioral activation by the neuroactive steroid 3?-Hydroxy-5?-Pregnan-20-One Hemisuccinate. 30th New England Pharmacologist Meeting,. 2001.
  47. Sadri, G., Johnson, D.W., Janis, G.C., Gibbs, T.T., Pierce, R.C., and Farb, D.H. . Inhibition of dopamine release through modulation of excitatory amino acid receptors by a neuroactive steroid. Society for Neuroscience 30th Annual Meeting,. 2000.
  48. Sadri, G., Johnson, D.W., Janis, G.C., Pierce, R.C., and Farb, D.H. Neurosteroids modulate excitatory amino acid receptor-mediated dopamine release in the striatum of awake rats. American Society for Pharmacology and Experimental Therapeutics Meeting,. 2000.
  49. Sadri, G., Johnson, D.W., Janis, G.C., Pierce, R.C., and Farb, D.H. Neurosteroids modulate excitatory amino acid receptor-mediated dopamine release in the striatum of awake rats. 6th Annual Russek Student Achievement Day. 2000.
  50. Sadri, G., Johnson, D.W., Janis, G.C., Pierce, R.C., and Farb, D.H. . Neurosteroids modulate excitatory amino acid receptor-mediated dopamine release in the striatum of awake rats. New England Pharmacologists 29th Annual Meeting,. 2000.
  51. Sadri, G., Janis, G.C., Pierce, R.C., Johnson, D.W., and Farb, D.H. Pregnanolone hemisuccinate negatively modulates ionotropic glutamate receptors in the rat striatum as measured by in vivo microdialysis. 5th Annual Russek Student Achievement Day. 1999.
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