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Mary-Elizabeth Patti, M.D.

TitleAssistant Professor of Medicine
InstitutionJoslin Diabetes Center
DepartmentMedicine
AddressJoslin Diabetes Center
Cellular & Mol. Physiology
One Joslin Place
Boston MA 02215
Phone617/735-1966
Fax617/735-1970

 Mentoring 
 current student opportunities
Available: 09/01/13, Expires: 08/31/14

Obesity and type 2 diabetes (T2D) are major public health challenges for our generation. Particularly concerning is the rise in obesity in the pediatric population, the anticipated rise in premature morbidity and mortality with long-standing obesity and costs associated with obesity-related. In parallel, recent projections suggest that prevalence of diabetes is likely to increase to over 25% of the US population by 2050, yielding enormous tolls at individual, public health, and economic levels. Unfortunately, there are no simple answers for the dual epidemics of obesity and T2D. Novel insights and approaches on many fronts are required.

Risk patterns for both obesity and T2D can originate as a consequence of alterations in growth and metabolism during critical windows of prenatal and early postnatal development. Moreover, obesity, prediabetes, and diabetes in individuals of reproductive age can initiate a vicious cycle, propagating risk to subsequent generations via non-genetic, or epi-genetic and metabolic mechanisms. Thus, understanding mechanisms mediating these effects is an important scientific and clinical goal. More importantly, this concept provides the hope that identification of high-risk individuals for targeted intervention during early childhood and subsequent reproductive life may limit vicious cycles of metabolic risk.

One example of nutritionally-mediated transmission of metabolic phenotypes is provided from our laboratory’s mouse model in which healthy pregnant mothers (F0) are exposed to modified nutrition during the last third of pregnancy. Their offspring (F1) have a modest 15% reduction in birth weight and experience early postnatal “catch-up growth.” Despite normal chow diet after weaning, these UN-exposed mice go on to develop progressive glucose intolerance, insulin secretory dysfunction, reduced muscle mass, and obesity as adults. UN exposed mice have upregulation of lipogenic gene expression in both liver and adipose, increased adipocyte size, and reduced mitochondrial DNA content. We have recently demonstrated that UN-exposed mice also have reduced numbers of myogenic precursor cells, suggesting the possibility that alterations in key stem cell populations may alter developmental trajectories and modify tissue structure/function and repair. The goal of the current study is to examine patterns of transcriptional dysregulation in myoblasts isolated from skeletal muscle from at-risk mice, and in parallel, to identify potential epigenetic mediators resulting from exposure to nutritional stress during pregnancy.


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Genomics and PCR Core (JDC) - Core services (15), Instruments (9) and Software (2)

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Goldfine AB, Patti ME. Diabetes: Bariatric surgery for T2DM-cure, or remission and relapse? Nat Rev Endocrinol. 2014 Jan; 10(1):8-9.
    View in: PubMed
  2. Colaneri A, Wang T, Pagadala V, Kittur J, Staffa NG, Peddada SD, Isganaitis E, Patti ME, Birnbaumer L. A Minimal Set of Tissue-Specific Hypomethylated CpGs Constitute Epigenetic Signatures of Developmental Programming. PLoS One. 2013; 8(9):e72670.
    View in: PubMed
  3. Patti ME. Reducing maternal weight improves offspring metabolism and alters (or modulates) methylation. Proc Natl Acad Sci U S A. 2013 Aug 6; 110(32):12859-60.
    View in: PubMed
  4. Patti ME. Intergenerational programming of metabolic disease: evidence from human populations and experimental animal models. Cell Mol Life Sci. 2013 May; 70(9):1597-608.
    View in: PubMed
  5. Simonen M, Dali-Youcef N, Kaminska D, Venesmaa S, Käkelä P, Pääkkönen M, Hallikainen M, Kolehmainen M, Uusitupa M, Moilanen L, Laakso M, Gylling H, Patti ME, Auwerx J, Pihlajamäki J. Conjugated bile acids associate with altered rates of glucose and lipid oxidation after Roux-en-Y gastric bypass. Obes Surg. 2012 Sep; 22(9):1473-80.
    View in: PubMed
  6. Radford EJ, Isganaitis E, Jimenez-Chillaron J, Schroeder J, Molla M, Andrews S, Didier N, Charalambous M, McEwen K, Marazzi G, Sassoon D, Patti ME, Ferguson-Smith AC. An unbiased assessment of the role of imprinted genes in an intergenerational model of developmental programming. PLoS Genet. 2012; 8(4):e1002605.
    View in: PubMed
  7. Pihlajamäki J, Lerin C, Itkonen P, Boes T, Floss T, Schroeder J, Dearie F, Crunkhorn S, Burak F, Jimenez-Chillaron JC, Kuulasmaa T, Miettinen P, Park PJ, Nasser I, Zhao Z, Zhang Z, Xu Y, Wurst W, Ren H, Morris AJ, Stamm S, Goldfine AB, Laakso M, Patti ME. Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis. Cell Metab. 2011 Aug 3; 14(2):208-18.
    View in: PubMed
  8. Bezy O, Tran TT, Pihlajamäki J, Suzuki R, Emanuelli B, Winnay J, Mori MA, Haas J, Biddinger SB, Leitges M, Goldfine AB, Patti ME, King GL, Kahn CR. PKCd regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans. J Clin Invest. 2011 Jun; 121(6):2504-17.
    View in: PubMed
  9. Woo M, Isganaitis E, Cerletti M, Fitzpatrick C, Wagers AJ, Jimenez-Chillaron J, Patti ME. Early life nutrition modulates muscle stem cell number: implications for muscle mass and repair. Stem Cells Dev. 2011 Oct; 20(10):1763-9.
    View in: PubMed
  10. Jin W, Goldfine AB, Boes T, Henry RR, Ciaraldi TP, Kim EY, Emecan M, Fitzpatrick C, Sen A, Shah A, Mun E, Vokes V, Schroeder J, Tatro E, Jimenez-Chillaron J, Patti ME. Increased SRF transcriptional activity in human and mouse skeletal muscle is a signature of insulin resistance. J Clin Invest. 2011 Mar; 121(3):918-29.
    View in: PubMed
  11. Halperin F, Patti ME, Skow M, Bajwa M, Goldfine AB. Continuous glucose monitoring for evaluation of glycemic excursions after gastric bypass. J Obes. 2011; 2011:869536.
    View in: PubMed
  12. Ferguson-Smith AC, Patti ME. You are what your dad ate. Cell Metab. 2011 Feb 2; 13(2):115-7.
    View in: PubMed
  13. da-Silva WS, Ribich S, Arrojo e Drigo R, Castillo M, Patti ME, Bianco AC. The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure. FEBS Lett. 2011 Feb 4; 585(3):539-44.
    View in: PubMed
  14. Goldfine AB, Gerwien RW, Kolberg JA, O'Shea S, Hamren S, Hein GP, Xu XM, Patti ME. Biomarkers in fasting serum to estimate glucose tolerance, insulin sensitivity, and insulin secretion. Clin Chem. 2011 Feb; 57(2):326-37.
    View in: PubMed
  15. Reubi JC, Perren A, Rehmann R, Waser B, Christ E, Callery M, Goldfine AB, Patti ME. Glucagon-like peptide-1 (GLP-1) receptors are not overexpressed in pancreatic islets from patients with severe hyperinsulinaemic hypoglycaemia following gastric bypass. Diabetologia. 2010 Dec; 53(12):2641-5.
    View in: PubMed
  16. Patti ME, Goldfine AB. Hypoglycaemia following gastric bypass surgery--diabetes remission in the extreme? Diabetologia. 2010 Nov; 53(11):2276-9.
    View in: PubMed
  17. Patti ME. Rehashing endocannabinoid antagonists: can we selectively target the periphery to safely treat obesity and type 2 diabetes? J Clin Invest. 2010 Aug; 120(8):2646-8.
    View in: PubMed
  18. Hall JA, Ribich S, Christoffolete MA, Simovic G, Correa-Medina M, Patti ME, Bianco AC. Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis. Endocrinology. 2010 Sep; 151(9):4573-82.
    View in: PubMed
  19. Castillo M, Freitas BC, Rosene ML, Drigo RA, Grozovsky R, Maciel RM, Patti ME, Ribeiro MO, Bianco AC. Impaired metabolic effects of a thyroid hormone receptor beta-selective agonist in a mouse model of diet-induced obesity. Thyroid. 2010 May; 20(5):545-53.
    View in: PubMed
  20. Zelezniak A, Pers TH, Soares S, Patti ME, Patil KR. Metabolic network topology reveals transcriptional regulatory signatures of type 2 diabetes. PLoS Comput Biol. 2010 Apr; 6(4):e1000729.
    View in: PubMed
  21. Halperin F, Patti ME, Goldfine AB. Glucagon treatment for post-gastric bypass hypoglycemia. Obesity (Silver Spring). 2010 Sep; 18(9):1858-60.
    View in: PubMed
  22. Patti ME, Corvera S. The role of mitochondria in the pathogenesis of type 2 diabetes. Endocr Rev. 2010 Jun; 31(3):364-95.
    View in: PubMed
  23. Espinoza DO, Boros LG, Crunkhorn S, Gami H, Patti ME. Dual modulation of both lipid oxidation and synthesis by peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in cultured myotubes. FASEB J. 2010 Apr; 24(4):1003-14.
    View in: PubMed
  24. Pihlajamäki J, Boes T, Kim EY, Dearie F, Kim BW, Schroeder J, Mun E, Nasser I, Park PJ, Bianco AC, Goldfine AB, Patti ME. Thyroid hormone-related regulation of gene expression in human fatty liver. J Clin Endocrinol Metab. 2009 Sep; 94(9):3521-9.
    View in: PubMed
  25. Wang XL, Suzuki R, Lee K, Tran T, Gunton JE, Saha AK, Patti ME, Goldfine A, Ruderman NB, Gonzalez FJ, Kahn CR. Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones. Cell Metab. 2009 May; 9(5):428-39.
    View in: PubMed
  26. Patti ME, Houten SM, Bianco AC, Bernier R, Larsen PR, Holst JJ, Badman MK, Maratos-Flier E, Mun EC, Pihlajamaki J, Auwerx J, Goldfine AB. Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism. Obesity (Silver Spring). 2009 Sep; 17(9):1671-7.
    View in: PubMed
  27. Sutherland AP, Zhang H, Zhang Y, Michaud M, Xie Z, Patti ME, Grusby MJ, Zhang WJ. Zinc finger protein Zbtb20 is essential for postnatal survival and glucose homeostasis. Mol Cell Biol. 2009 May; 29(10):2804-15.
    View in: PubMed
  28. Apovian CM, Cummings S, Anderson W, Borud L, Boyer K, Day K, Hatchigian E, Hodges B, Patti ME, Pettus M, Perna F, Rooks D, Saltzman E, Skoropowski J, Tantillo MB, Thomason P. Best practice updates for multidisciplinary care in weight loss surgery. Obesity (Silver Spring). 2009 May; 17(5):871-9.
    View in: PubMed
  29. Isganaitis E, Jimenez-Chillaron J, Woo M, Chow A, DeCoste J, Vokes M, Liu M, Kasif S, Zavacki AM, Leshan RL, Myers MG, Patti ME. Accelerated postnatal growth increases lipogenic gene expression and adipocyte size in low-birth weight mice. Diabetes. 2009 May; 58(5):1192-200.
    View in: PubMed
  30. Jin W, Patti ME. Genetic determinants and molecular pathways in the pathogenesis of Type 2 diabetes. Clin Sci (Lond). 2009 Jan; 116(2):99-111.
    View in: PubMed
  31. Grozovsky R, Ribich S, Rosene ML, Mulcahey MA, Huang SA, Patti ME, Bianco AC, Kim BW. Type 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes. Endocrinology. 2009 Apr; 150(4):1976-83.
    View in: PubMed
  32. Jimenez-Chillaron JC, Isganaitis E, Charalambous M, Gesta S, Pentinat-Pelegrin T, Faucette RR, Otis JP, Chow A, Diaz R, Ferguson-Smith A, Patti ME. Intergenerational transmission of glucose intolerance and obesity by in utero undernutrition in mice. Diabetes. 2009 Feb; 58(2):460-8.
    View in: PubMed
  33. Doria A, Patti ME, Kahn CR. The emerging genetic architecture of type 2 diabetes. Cell Metab. 2008 Sep; 8(3):186-200.
    View in: PubMed
  34. Ruddock MW, Stein A, Landaker E, Park J, Cooksey RC, McClain D, Patti ME. Saturated fatty acids inhibit hepatic insulin action by modulating insulin receptor expression and post-receptor signalling. J Biochem. 2008 Nov; 144(5):599-607.
    View in: PubMed
  35. Isshiki K, He Z, Maeno Y, Ma RC, Yasuda Y, Kuroki T, White GS, Patti ME, Weir GC, King GL. Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells. Kidney Int. 2008 Dec; 74(11):1434-43.
    View in: PubMed
  36. Woo M, Patti ME. Diabetes risk begins in utero. Cell Metab. 2008 Jul; 8(1):5-7.
    View in: PubMed
  37. Crunkhorn S, Patti ME. Links between thyroid hormone action, oxidative metabolism, and diabetes risk? Thyroid. 2008 Feb; 18(2):227-37.
    View in: PubMed
  38. Goldfine AB, Mun EC, Devine E, Bernier R, Baz-Hecht M, Jones DB, Schneider BE, Holst JJ, Patti ME. Patients with neuroglycopenia after gastric bypass surgery have exaggerated incretin and insulin secretory responses to a mixed meal. J Clin Endocrinol Metab. 2007 Dec; 92(12):4678-85.
    View in: PubMed
  39. Crunkhorn S, Dearie F, Mantzoros C, Gami H, da Silva WS, Espinoza D, Faucette R, Barry K, Bianco AC, Patti ME. Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation. J Biol Chem. 2007 May 25; 282(21):15439-50.
    View in: PubMed
  40. Oge A, Isganaitis E, Jimenez-Chillaron J, Reamer C, Faucette R, Barry K, Przybyla R, Patti ME. In utero undernutrition reduces diabetes incidence in non-obese diabetic mice. Diabetologia. 2007 May; 50(5):1099-108.
    View in: PubMed
  41. Arikawa E, Ma RC, Isshiki K, Luptak I, He Z, Yasuda Y, Maeno Y, Patti ME, Weir GC, Harris RA, Zammit VA, Tian R, King GL. Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats. Diabetes. 2007 May; 56(5):1410-20.
    View in: PubMed
  42. Jimenez-Chillaron JC, Patti ME. To catch up or not to catch up: is this the question? Lessons from animal models. Curr Opin Endocrinol Diabetes Obes. 2007 Feb; 14(1):23-9.
    View in: PubMed
  43. Hernandez-Valencia M, Patti ME. A thin phenotype is protective for impaired glucose tolerance and related to low birth weight in mice. Arch Med Res. 2006 Oct; 37(7):813-7.
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  44. Jimenez-Chillaron JC, Hernandez-Valencia M, Lightner A, Faucette RR, Reamer C, Przybyla R, Ruest S, Barry K, Otis JP, Patti ME. Reductions in caloric intake and early postnatal growth prevent glucose intolerance and obesity associated with low birthweight. Diabetologia. 2006 Aug; 49(8):1974-84.
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  45. Tiffin N, Adie E, Turner F, Brunner HG, van Driel MA, Oti M, Lopez-Bigas N, Ouzounis C, Perez-Iratxeta C, Andrade-Navarro MA, Adeyemo A, Patti ME, Semple CA, Hide W. Computational disease gene identification: a concert of methods prioritizes type 2 diabetes and obesity candidate genes. Nucleic Acids Res. 2006; 34(10):3067-81.
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  46. Goldfine AB, Beckman JA, Betensky RA, Devlin H, Hurley S, Varo N, Schonbeck U, Patti ME, Creager MA. Family history of diabetes is a major determinant of endothelial function. J Am Coll Cardiol. 2006 Jun 20; 47(12):2456-61.
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  47. Ilany J, Bilan PJ, Kapur S, Caldwell JS, Patti ME, Marette A, Kahn CR. Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level. Proc Natl Acad Sci U S A. 2006 Mar 21; 103(12):4481-6.
    View in: PubMed
  48. Goldfine AB, Crunkhorn S, Costello M, Gami H, Landaker EJ, Niinobe M, Yoshikawa K, Lo D, Warren A, Jimenez-Chillaron J, Patti ME. Necdin and E2F4 are modulated by rosiglitazone therapy in diabetic human adipose and muscle tissue. Diabetes. 2006 Mar; 55(3):640-50.
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  49. Kuhl JE, Ruderman NB, Musi N, Goodyear LJ, Patti ME, Crunkhorn S, Dronamraju D, Thorell A, Nygren J, Ljungkvist O, Degerblad M, Stahle A, Brismar TB, Andersen KL, Saha AK, Efendic S, Bavenholm PN. Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle. Am J Physiol Endocrinol Metab. 2006 Jun; 290(6):E1296-303.
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  50. Myers MG, Patti ME, Leshan RL. Hitting the target: leptin and perinatal nutrition in the predisposition to obesity. Endocrinology. 2005 Oct; 146(10):4209-10.
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  51. Patti ME, McMahon G, Mun EC, Bitton A, Holst JJ, Goldsmith J, Hanto DW, Callery M, Arky R, Nose V, Bonner-Weir S, Goldfine AB. Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia. Diabetologia. 2005 Nov; 48(11):2236-40.
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  52. Halperin F, Beckman JA, Patti ME, Trujillo ME, Garvin M, Creager MA, Scherer PE, Goldfine AB. The role of total and high-molecular-weight complex of adiponectin in vascular function in offspring whose parents both had type 2 diabetes. Diabetologia. 2005 Oct; 48(10):2147-54.
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  53. Tseng YH, Butte AJ, Kokkotou E, Yechoor VK, Taniguchi CM, Kriauciunas KM, Cypess AM, Niinobe M, Yoshikawa K, Patti ME, Kahn CR. Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nat Cell Biol. 2005 Jun; 7(6):601-11.
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  54. Jimenez-Chillaron JC, Hernandez-Valencia M, Reamer C, Fisher S, Joszi A, Hirshman M, Oge A, Walrond S, Przybyla R, Boozer C, Goodyear LJ, Patti ME. Beta-cell secretory dysfunction in the pathogenesis of low birth weight-associated diabetes: a murine model. Diabetes. 2005 Mar; 54(3):702-11.
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  55. Gordon LB, Harten IA, Patti ME, Lichtenstein AH. Reduced adiponectin and HDL cholesterol without elevated C-reactive protein: clues to the biology of premature atherosclerosis in Hutchinson-Gilford Progeria Syndrome. J Pediatr. 2005 Mar; 146(3):336-41.
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  56. Yechoor VK, Patti ME, Ueki K, Laustsen PG, Saccone R, Rauniyar R, Kahn CR. Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice. Proc Natl Acad Sci U S A. 2004 Nov 23; 101(47):16525-30.
    View in: PubMed
  57. Patti ME, Kahn BB. Nutrient sensor links obesity with diabetes risk. Nat Med. 2004 Oct; 10(10):1049-50.
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  58. Patti ME. Gene expression in humans with diabetes and prediabetes: what have we learned about diabetes pathophysiology? Curr Opin Clin Nutr Metab Care. 2004 Jul; 7(4):383-90.
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  59. Patti ME. Gene expression in the pathophysiology of type 2 diabetes mellitus. Curr Diab Rep. 2004 Jun; 4(3):176-81.
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  60. Blüher M, Patti ME, Gesta S, Kahn BB, Kahn CR. Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression. J Biol Chem. 2004 Jul 23; 279(30):31891-901.
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  61. Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, Miyazaki Y, Kohane I, Costello M, Saccone R, Landaker EJ, Goldfine AB, Mun E, DeFronzo R, Finlayson J, Kahn CR, Mandarino LJ. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A. 2003 Jul 8; 100(14):8466-71.
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  62. Combs TP, Berg AH, Rajala MW, Klebanov S, Iyengar P, Jimenez-Chillaron JC, Patti ME, Klein SL, Weinstein RS, Scherer PE. Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin. Diabetes. 2003 Feb; 52(2):268-76.
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  63. Yechoor VK, Patti ME, Saccone R, Kahn CR. Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice. Proc Natl Acad Sci U S A. 2002 Aug 6; 99(16):10587-92.
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  64. Fraenkel PG, Rutkove SB, Matheson JK, Fowkes M, Cannon ME, Patti ME, Atkins MB, Gollob JA. Induction of myasthenia gravis, myositis, and insulin-dependent diabetes mellitus by high-dose interleukin-2 in a patient with renal cell cancer. J Immunother. 2002 Jul-Aug; 25(4):373-8.
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  65. Orban T, Landaker E, Ruan Z, Cordeman TP, Weitgasser R, Bonner-Weir S, Jackson RA, Patti ME. High-fructose diet preserves beta-cell mass and prevents diabetes in nonobese diabetic mice: A potential role for increased insulin receptor substrate-2 expression. Metabolism. 2001 Nov; 50(11):1369-76.
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  66. Rosas HD, Goodman J, Chen YI, Jenkins BG, Kennedy DN, Makris N, Patti M, Seidman LJ, Beal MF, Koroshetz WJ. Striatal volume loss in HD as measured by MRI and the influence of CAG repeat. Neurology. 2001 Sep 25; 57(6):1025-8.
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  67. Goldfine AB, Patti ME, Zuberi L, Goldstein BJ, LeBlanc R, Landaker EJ, Jiang ZY, Willsky GR, Kahn CR. Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies. Metabolism. 2000 Mar; 49(3):400-10.
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  68. Cusi K, Maezono K, Osman A, Pendergrass M, Patti ME, Pratipanawatr T, DeFronzo RA, Kahn CR, Mandarino LJ. Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle. J Clin Invest. 2000 Feb; 105(3):311-20.
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  69. Patti ME. Nutrient modulation of cellular insulin action. Ann N Y Acad Sci. 1999 Nov 18; 892:187-203.
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  70. Patti ME, Virkamäki A, Landaker EJ, Kahn CR, Yki-Järvinen H. Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle. Diabetes. 1999 Aug; 48(8):1562-71.
    View in: PubMed
  71. Koval JA, Maezono K, Patti ME, Pendergrass M, DeFronzo RA, Mandarino LJ. Effects of exercise and insulin on insulin signaling proteins in human skeletal muscle. Med Sci Sports Exerc. 1999 Jul; 31(7):998-1004.
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  72. Patti ME, Brambilla E, Luzi L, Landaker EJ, Kahn CR. Bidirectional modulation of insulin action by amino acids. J Clin Invest. 1998 Apr 1; 101(7):1519-29.
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  73. Patti ME, Kahn CR. The insulin receptor--a critical link in glucose homeostasis and insulin action. J Basic Clin Physiol Pharmacol. 1998; 9(2-4):89-109.
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  74. Smith-Hall J, Pons S, Patti ME, Burks DJ, Yenush L, Sun XJ, Kahn CR, White MF. The 60 kDa insulin receptor substrate functions like an IRS protein (pp60IRS3) in adipose cells. Biochemistry. 1997 Jul 8; 36(27):8304-10.
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  75. Patti ME, Kahn CR. Lessons from transgenic and knockout animals about noninsulin-dependent diabetes mellitus. Trends Endocrinol Metab. 1996 Nov; 7(9):311-9.
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  76. Goldfine AB, Simonson DC, Folli F, Patti ME, Kahn CR. In vivo and in vitro studies of vanadate in human and rodent diabetes mellitus. Mol Cell Biochem. 1995 Dec 6-20; 153(1-2):217-31.
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  77. Goldfine AB, Simonson DC, Folli F, Patti ME, Kahn CR. Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies. J Clin Endocrinol Metab. 1995 Nov; 80(11):3311-20.
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  78. Patti ME, Sun XJ, Bruening JC, Araki E, Lipes MA, White MF, Kahn CR. 4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice. J Biol Chem. 1995 Oct 20; 270(42):24670-3.
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  79. Araki E, Lipes MA, Patti ME, Brüning JC, Haag B, Johnson RS, Kahn CR. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature. 1994 Nov 10; 372(6502):186-90.
    View in: PubMed
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