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Didier Alain Mandelbrot, M.D.

TitleAssociate Professor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Medical Center
The Transplant Center
110 Francis Street
Boston MA 02215
Phone617/632-9700
Fax617/632-9820

 Mentoring 
 current student opportunities
Available: 07/01/11, Expires: 06/30/13

The student would have access to our extensive database on former kidney donors. This would allow identification of former donors who developed renal insufficiency, hypertension or proteinuria, and to examine which pre-donation factors predict these adverse outcomes.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Rodrigue JR, Paek MJ, Egbuna O, Waterman AD, Pavlakis M, Mandelbrot DA. Willingness to Pursue Live-Donor Kidney Transplantation Among Waitlisted Patients Infected With Human Immunodeficiency Virus (HIV): A Preliminary Investigation. Transplantation. 2013 Mar 27; 95(6):787-90.
    View in: PubMed
  2. Kher A, Raven KE, Kushner YB, Mandelbrot DA. Fever, abdominal pain and renal failure in a kidney transplant recipient. Am J Transplant. 2013 Feb; 13(2):518-20.
    View in: PubMed
  3. Kher A, Rodrigue J, Ajaimy M, Wasilewski M, Ladin K, Mandelbrot D. Reimbursement for living kidney donor follow-up care: how often does donor insurance pay? Transplantation. 2012 Nov 27; 94(10):1049-51.
    View in: PubMed
  4. Mandelbrot DA, Pavlakis M. Living donor practices in the United States. Adv Chronic Kidney Dis. 2012 Jul; 19(4):212-9.
    View in: PubMed
  5. Johnson SR, Karp SJ, Curry MP, Barugel M, Rodrigue JR, Mandelbrot DA, Rogers CP, Hanto DW. Liver transplant center risk tolerance. Clin Transplant. 2012 May-Jun; 26(3):E269-76.
    View in: PubMed
  6. Rodrigue JR, Pavlakis M, Egbuna O, Paek M, Waterman AD, Mandelbrot DA. The "House Calls" trial: a randomized controlled trial to reduce racial disparities in live donor kidney transplantation: rationale and design. Contemp Clin Trials. 2012 Jul; 33(4):811-8.
    View in: PubMed
  7. Francis JM, Palmer MR, Donohoe K, Curry M, Johnson SR, Karp SJ, Evenson AR, Pavlakis M, Hanto DW, Mandelbrot DA. Evaluation of native kidney recovery after simultaneous liver-kidney transplantation. Transplantation. 2012 Mar 15; 93(5):530-5.
    View in: PubMed
  8. Kher A, Mandelbrot DA. The living kidney donor evaluation: focus on renal issues. Clin J Am Soc Nephrol. 2012 Feb; 7(2):366-71.
    View in: PubMed
  9. Hamburger M, Baraf HS, Adamson TC, Basile J, Bass L, Cole B, Doghramji PP, Guadagnoli GA, Hamburger F, Harford R, Lieberman JA, Mandel DR, Mandelbrot DA, McClain BP, Mizuno E, Morton AH, Mount DB, Pope RS, Rosenthal KG, Setoodeh K, Skosey JL, Edwards NL. 2011 recommendations for the diagnosis and management of gout and hyperuricemia. Phys Sportsmed. 2011 Nov; 39(4):98-123.
    View in: PubMed
  10. Hamburger M, Baraf HS, Adamson TC, Basile J, Bass L, Cole B, Doghramji PP, Guadagnoli GA, Hamburger F, Harford R, Lieberman JA, Mandel DR, Mandelbrot DA, McClain BP, Mizuno E, Morton AH, Mount DB, Pope RS, Rosenthal KG, Setoodeh K, Skosey JL, Edwards NL. 2011 Recommendations for the diagnosis and management of gout and hyperuricemia. Postgrad Med. 2011 Nov; 123(6 Suppl 1):3-36.
    View in: PubMed
  11. Rodrigue JR, Ladin K, Pavlakis M, Mandelbrot DA. Disclosing recipient information to potential living donors: preferences of donors and recipients, before and after surgery. Am J Transplant. 2011 Jun; 11(6):1270-8.
    View in: PubMed
  12. McMahon G, Weir MR, Li XC, Mandelbrot DA. The evolving role of mTOR inhibition in transplantation tolerance. J Am Soc Nephrol. 2011 Mar; 22(3):408-15.
    View in: PubMed
  13. Rodrigue JR, Dimitri N, Reed A, Antonellis T, Pavlakis M, Johnson SR, Mandelbrot DA. Spouse caregivers of kidney transplant patients: quality of life and psychosocial outcomes. Prog Transplant. 2010 Dec; 20(4):335-42; quiz 343.
    View in: PubMed
  14. Rodrigue JR, Mandelbrot DA, Hanto DW, Johnson SR, Karp SJ, Pavlakis M. A cross-sectional study of fatigue and sleep quality before and after kidney transplantation. Clin Transplant. 2011 Jan-Feb; 25(1):E13-21.
    View in: PubMed
  15. Mawardi H, Pavlakis M, Mandelbrot D, Woo SB. Sirolimus oral ulcer with Cedecea davisae superinfection. Transpl Infect Dis. 2010 Oct; 12(5):446-50.
    View in: PubMed
  16. Rodrigue JR, Mandelbrot DA, Pavlakis M. A psychological intervention to improve quality of life and reduce psychological distress in adults awaiting kidney transplantation. Nephrol Dial Transplant. 2011 Feb; 26(2):709-15.
    View in: PubMed
  17. Pavlakis M, Khwaja K, Mandelbrot D, Tang H, Whiting JW, Lorber MI, Gautam A, Johnson SR, Uknis ME. Renal allograft failure predictors after PAK transplantation: results from the New England Collaborative Association of Pancreas Programs. Transplantation. 2010 Jun 15; 89(11):1347-53.
    View in: PubMed
  18. Weir MR, Diekmann F, Flechner SM, Lebranchu Y, Mandelbrot DA, Oberbauer R, Kahan BD. mTOR inhibition: the learning curve in kidney transplantation. Transpl Int. 2010 May 1; 23(5):447-60.
    View in: PubMed
  19. Chudzinski RE, Khwaja K, Teune P, Miller J, Tang H, Pavlakis M, Rogers C, Johnson S, Karp S, Hanto D, Mandelbrot D. Successful DCD kidney transplantation using early corticosteroid withdrawal. Am J Transplant. 2010 Jan; 10(1):115-23.
    View in: PubMed
  20. Mandelbrot DA, Pavlakis M, Karp SJ, Johnson SR, Hanto DW, Rodrigue JR. Practices and barriers in long-term living kidney donor follow-up: a survey of U.S. transplant centers. Transplantation. 2009 Oct 15; 88(7):855-60.
    View in: PubMed
  21. Egbuna OI, Davis RB, Chudinski R, Pavlakis M, Rogers C, Molakatalla P, Johnson SR, Karp S, Monaco AP, Tang H, Hanto DW, Mandelbrot DA. Outcomes with conversion from calcineurin inhibitors to sirolimus after renal transplantation in the context of steroid withdrawal or steroid continuation. Transplantation. 2009 Sep 15; 88(5):684-92.
    View in: PubMed
  22. Rogers CC, Johnson SR, Mandelbrot DA, Pavlakis M, Horwedel T, Karp SJ, Egbuna O, Rodrigue JR, Chudzinski RE, Goldfarb-Rumyantzev AS, Hanto DW, Curry MP. Timing of sirolimus conversion influences recovery of renal function in liver transplant recipients. Clin Transplant. 2009 Nov-Dec; 23(6):887-96.
    View in: PubMed
  23. Mandelbrot D. Anti-IL-2 receptor antibodies versus anti-thymocyte globulin for induction therapy in kidney transplantation. J Am Soc Nephrol. 2009 Jun; 20(6):1170-1.
    View in: PubMed
  24. Rodrigue JR, Antonellis T, Mandelbrot DA, Hanto DW. Web-based requests for living organ donors: who are the solicitors? Clin Transplant. 2008 Nov-Dec; 22(6):749-53.
    View in: PubMed
  25. Ho KJ, Owens CD, Johnson SR, Khwaja K, Curry MP, Pavlakis M, Mandelbrot D, Pomposelli JJ, Shah SA, Saidi RF, Ko DS, Malek S, Belcher J, Hull D, Tullius SG, Freeman RB, Pomfret EA, Whiting JF, Hanto DW, Karp SJ. Donor postextubation hypotension and age correlate with outcome after donation after cardiac death transplantation. Transplantation. 2008 Jun 15; 85(11):1588-94.
    View in: PubMed
  26. Rodrigue JR, Guenther R, Kaplan B, Mandelbrot DA, Pavlakis M, Howard RJ. Measuring the expectations of kidney donors: initial psychometric properties of the Living Donation Expectancies Questionnaire. Transplantation. 2008 May 15; 85(9):1230-4.
    View in: PubMed
  27. Mandelbrot DA, Santos PW, Burt RK, Oyama Y, Block GA, Ahya SN, Rosa RM, Traynor AE. Resolution of SLE-related soft-tissue calcification following haematopoietic stem cell transplantation. Nephrol Dial Transplant. 2008 Aug; 23(8):2679-84.
    View in: PubMed
  28. Tarkan JL, Woo SB, Pavlakis M, Johnson SR, Chirieac LR, Chimienti SN, Mandelbrot DA. Spotting the owl: surreptitious cytomegalovirus disease in a renal transplant recipient. Clin Transplant. 2008 May-Jun; 22(3):391-5.
    View in: PubMed
  29. Pavlakis M, Hanto D, Mandelbrot D. Do we know enough to mandate donor evaluation testing? Am J Transplant. 2008 Feb; 8(2):466.
    View in: PubMed
  30. Mandelbrot DA, Dhaliwal SK, Evan NR, Licho R, Reinhardt CP, Jaffry S. Validation of neutron activation as a novel method to determine glomerular filtration rate. Nephron Clin Pract. 2007; 107(3):c117-22.
    View in: PubMed
  31. Rodrigue JR, Pavlakis M, Danovitch GM, Johnson SR, Karp SJ, Khwaja K, Hanto DW, Mandelbrot DA. Evaluating living kidney donors: relationship types, psychosocial criteria, and consent processes at US transplant programs. Am J Transplant. 2007 Oct; 7(10):2326-32.
    View in: PubMed
  32. Mandelbrot DA, Pavlakis M, Danovitch GM, Johnson SR, Karp SJ, Khwaja K, Hanto DW, Rodrigue JR. The medical evaluation of living kidney donors: a survey of US transplant centers. Am J Transplant. 2007 Oct; 7(10):2333-43.
    View in: PubMed
  33. Patlolla V, Zhong X, Reed GW, Mandelbrot DA. Efficacy of anti-IL-2 receptor antibodies compared to no induction and to antilymphocyte antibodies in renal transplantation. Am J Transplant. 2007 Jul; 7(7):1832-42.
    View in: PubMed
  34. Read S, Greenwald R, Izcue A, Robinson N, Mandelbrot D, Francisco L, Sharpe AH, Powrie F. Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo. J Immunol. 2006 Oct 1; 177(7):4376-83.
    View in: PubMed
  35. Yamada A, Salama AD, Sho M, Najafian N, Ito T, Forman JP, Kewalramani R, Sandner S, Harada H, Clarkson MR, Mandelbrot DA, Sharpe AH, Oshima H, Yagita H, Chalasani G, Lakkis FG, Auchincloss H, Sayegh MH. CD70 signaling is critical for CD28-independent CD8+ T cell-mediated alloimmune responses in vivo. J Immunol. 2005 Feb 1; 174(3):1357-64.
    View in: PubMed
  36. Kishimoto K, Yuan X, Auchincloss H, Sharpe AH, Mandelbrot DA, Sayegh MH. Mechanism of action of donor-specific transfusion in inducing tolerance: role of donor MHC molecules, donor co-stimulatory molecules, and indirect antigen presentation. J Am Soc Nephrol. 2004 Sep; 15(9):2423-8.
    View in: PubMed
  37. Ariyan C, Salvalaggio P, Fecteau S, Deng S, Rogozinski L, Mandelbrot D, Sharpe A, Sayegh MH, Basadonna GP, Rothstein DM. Cutting edge: transplantation tolerance through enhanced CTLA-4 expression. J Immunol. 2003 Dec 1; 171(11):5673-7.
    View in: PubMed
  38. DeFina R, Christopher K, He H, Mandelbrot D, Gu Y, Finn P, Perkins DL. Analysis of costimulation by 4-1BBL, CD40L, and B7 in graft rejection by gene expression profiles. J Mol Med (Berl). 2003 Oct; 81(10):655-63.
    View in: PubMed
  39. Albert DA, Cohen AJ, Mandelbrot DA, Reinhardt CP, Dickson EW. Neutron-activation analysis: a novel method for the assay of iohexol. J Lab Clin Med. 2003 Feb; 141(2):106-9.
    View in: PubMed
  40. Hodur DM, Mandelbrot D. Immunosuppression and BKV Nephropathy. N Engl J Med. 2002 Dec 19; 347(25):2079-80; author reply 2079-80.
    View in: PubMed
  41. Schneider H, Mandelbrot DA, Greenwald RJ, Ng F, Lechler R, Sharpe AH, Rudd CE. Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient mice. J Immunol. 2002 Oct 1; 169(7):3475-9.
    View in: PubMed
  42. Greenwald RJ, Oosterwegel MA, van der Woude D, Kubal A, Mandelbrot DA, Boussiotis VA, Sharpe AH. CTLA-4 regulates cell cycle progression during a primary immune response. Eur J Immunol. 2002 Feb; 32(2):366-73.
    View in: PubMed
  43. Mandelbrot DA, Kishimoto K, Auchincloss H, Sharpe AH, Sayegh MH. Rejection of mouse cardiac allografts by costimulation in trans. J Immunol. 2001 Aug 1; 167(3):1174-8.
    View in: PubMed
  44. Yamada A, Kishimoto K, Dong VM, Sho M, Salama AD, Anosova NG, Benichou G, Mandelbrot DA, Sharpe AH, Turka LA, Auchincloss H, Sayegh MH. CD28-independent costimulation of T cells in alloimmune responses. J Immunol. 2001 Jul 1; 167(1):140-6.
    View in: PubMed
  45. Mandelbrot DA, Oosterwegel MA, Shimizu K, Yamada A, Freeman GJ, Mitchell RN, Sayegh MH, Sharpe AH. B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4. J Clin Invest. 2001 Apr; 107(7):881-7.
    View in: PubMed
  46. Furukawa Y, Mandelbrot DA, Libby P, Sharpe AH, Mitchell RN. Association of B7-1 co-stimulation with the development of graft arterial disease. Studies using mice lacking B7-1, B7-2, or B7-1/B7-2. Am J Pathol. 2000 Aug; 157(2):473-84.
    View in: PubMed
  47. Taraszka KS, Higgins JM, Tan K, Mandelbrot DA, Wang JH, Brenner MB. Molecular basis for leukocyte integrin alpha(E)beta(7) adhesion to epithelial (E)-cadherin. J Exp Med. 2000 May 1; 191(9):1555-67.
    View in: PubMed
  48. Mandelbrot DA, Furukawa Y, McAdam AJ, Alexander SI, Libby P, Mitchell RN, Sharpe AH. Expression of B7 molecules in recipient, not donor, mice determines the survival of cardiac allografts. J Immunol. 1999 Oct 1; 163(7):3753-7.
    View in: PubMed
  49. Oosterwegel MA, Mandelbrot DA, Boyd SD, Lorsbach RB, Jarrett DY, Abbas AK, Sharpe AH. The role of CTLA-4 in regulating Th2 differentiation. J Immunol. 1999 Sep 1; 163(5):2634-9.
    View in: PubMed
  50. Oosterwegel MA, Greenwald RJ, Mandelbrot DA, Lorsbach RB, Sharpe AH. CTLA-4 and T cell activation. Curr Opin Immunol. 1999 Jun; 11(3):294-300.
    View in: PubMed
  51. Mandelbrot DA, McAdam AJ, Sharpe AH. B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). J Exp Med. 1999 Jan 18; 189(2):435-40.
    View in: PubMed
  52. Russell GJ, Parker CM, Cepek KL, Mandelbrot DA, Sood A, Mizoguchi E, Ebert EC, Brenner MB, Bhan AK. Distinct structural and functional epitopes of the alpha E beta 7 integrin. Eur J Immunol. 1994 Nov; 24(11):2832-41.
    View in: PubMed
  53. Mandelbrot DA, Smythe WR, Norman SA, Martin SC, Arnold RM, Talbot GH, Stolley PD. A survey of exposures, practices and recommendations of surgeons in the care of patients with human immunodeficiency virus. Surg Gynecol Obstet. 1990 Aug; 171(2):99-106.
    View in: PubMed
  54. Goy MF, Mandelbrot DA, York CM. Identification and characterization of a polypeptide from a lobster neurosecretory gland that induces cyclic GMP accumulation in lobster neuromuscular preparations. J Neurochem. 1987 Mar; 48(3):954-66.
    View in: PubMed
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