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John Hedley-Whyte, M.D., M.B.,B.CH.

TitleDavid S. Sheridan Professor of Anaesthesia and Respiratory Therapy
InstitutionVeterans Affairs Boston Healthcare System
DepartmentAnaesthesia
AddressBoston VA Med Ctr-W Roxbury
1400 VFW Pkwy
West Roxbury MA 02132
Phone617/327-5563
Fax617/327-5563

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hedley-Whyte J, Milamed DR. Our blood your money. Ulster Med J. 2013 May; 82(2):114-20.
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  2. Milamed DR, Lasthaus H, Hedley-Whyte J. Improving patient safety and essential device performance: international standards for home respiratory care equipment. Biomed Instrum Technol. 2013; Suppl:53-7.
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  3. Hedley-Whyte J, Milamed DR. Tuberculous scrofula: Belfast experience. Ulster Med J. 2011 May; 80(2):97-103.
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  4. Hedley-Whyte J. Toward better medical alarm systems. Biomed Instrum Technol. 2011; Suppl:83-4.
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  5. Hedley-Whyte J, Milamed DR. Blood and war. Ulster Med J. 2010 Sep; 79(3):125-34.
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  6. Hedley-Whyte J, Milamed DR, Hoaglin DC. Chairpersons of pathology in the United States: limited benchmarks for publications. Am J Clin Pathol. 2010 Aug; 134(2):185-92.
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  7. Milamed DR, Lasthaus H, Hedley-Whyte J. Highlights of the new international standard on home healthcare devices. Biomed Instrum Technol. 2010; Suppl Home Healthcare:27-31.
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  8. Hedley-Whyte J, Milamed DR. Aspects of vitamin A. Ulster Med J. 2009 Sep; 78(3):171-8.
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  9. Hedley-Whyte J, Milamed DR. Lobar pneumonia treated by Musgrave Park physicians. Ulster Med J. 2009 May; 78(2):119-28.
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  10. Hedley-Whyte J, Milamed DR. Asbestos and ship-building: fatal consequences. Ulster Med J. 2008 Sep; 77(3):191-200.
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  11. Hedley-Whyte J, Milamed DR. Paratyphoid blamed on Ulster: a nursing odyssey. Ulster Med J. 2008 May; 77(2):119-26.
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  12. Hedley-Whyte J. Pulmonary oxygen toxicity: investigation and mentoring. Ulster Med J. 2008 Jan; 77(1):39-42.
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  13. Hedley-Whyte J. Frederick Mosteller (1916-2006): mentoring, a memoir. Int J Technol Assess Health Care. 2007; 23(1):152-4.
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  14. Hedley-Whyte J, Milamed DR. The evolution of sites of surgery. Ulster Med J. 2006 Jan; 75(1):46-53.
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  15. Hedley-Whyte J. Epidemic jaundice: Harvard's 5th General Hospital at Musgrave Park in World War II. Ulster Med J. 2005 Sep; 74(2):122-5.
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  16. Hedley-Whyte J, Milamed DR. Equipment standards: history, litigation, and advice. Ann Surg. 1999 Jul; 230(1):120-7.
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  17. Hedley-Whyte J, Godinez RI, Weitzner SW. Alarm signals used in anesthesia and intensive care. Anesthesiology. 1994 Nov; 81(5):1307-8.
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  18. Milamed DR, Hedley-Whyte J. Contributions of the surgical sciences to a reduction of the mortality rate in the United States for the period 1968 to 1988. Ann Surg. 1994 Jan; 219(1):94-102.
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  19. Milamed DR, Warfield CA, Hedley-Whyte J, Mosteller F. Laminectomy and the treatment of lower-back pain in Massachusetts. Int J Technol Assess Health Care. 1993; 9(3):426-39.
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  20. Bentkover JD, Sheshinski RH, Hedley-Whyte J, Warfield CA, Mosteller F. Lower back pain. Laminectomies, spinal fusions, demographics, and socioeconomics. Int J Technol Assess Health Care. 1992; 8(2):309-17.
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  21. Hedley-Whyte J. US and international standards for resuscitators. JAMA. 1989 Apr 7; 261(13):1880.
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  22. du Moulin GC, Stottmeier KD, Pelletier PA, Tsang AY, Hedley-Whyte J. Concentration of Mycobacterium avium by hospital hot water systems. JAMA. 1988 Sep 16; 260(11):1599-601.
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  23. Priebe HJ, Henke W, Hedley-Whyte J. Effects of tracheal intubation on laryngeal acoustic waveforms. Anesth Analg. 1988 Mar; 67(3):219-27.
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  24. du Moulin GC, Coleman EC, Hedley-Whyte J. Bacterial colonization and endotoxin content of a new renal dialysis water system composed of acrylonitrile butadiene styrene. Appl Environ Microbiol. 1987 Jun; 53(6):1322-6.
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  25. du Moulin GC, Lynch SE, Hedley-Whyte J, Broitman SA. The detection of gram-negative bacteria in the blood of septic rats by a Limulus amebocyte lysate assay. Prog Clin Biol Res. 1987; 231:349-56.
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  26. du Moulin GC, Paterson D, Hedley-Whyte J, Broitman SA. E. coli peritonitis and bacteremia cause increased blood-brain barrier permeability. Brain Res. 1985 Aug 12; 340(2):261-8.
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  27. du Moulin GC, Lynch SE, Hedley-Whyte J, Broitman SA. Detection of gram-negative bacteremia by limulus amebocyte lysate assay: evaluation in a rat model of peritonitis. J Infect Dis. 1985 Jan; 151(1):148-52.
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  28. Priebe HJ, Hedley-Whyte J. Respiratory support and renal function. Int Anesthesiol Clin. 1984; 22(1):203-26.
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  29. du Moulin GC, Hedley-Whyte J. Hospital-associated viral infection and the anesthesiologist. Anesthesiology. 1983 Jul; 59(1):51-65.
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  30. Priebe HJ, Hedley-Whyte J. Positive end-expiratory pressure (PEEP) and renal function. Anesthesiology. 1982 Aug; 57(2):144-5.
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  31. du Moulin GC, Hedley-Whyte J. Bacterial interactions between anesthesiologists, their patients, and equipment. Anesthesiology. 1982 Jul; 57(1):37-41.
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  32. du Moulin GC, Paterson DG, Hedley-Whyte J, Lisbon A. Aspiration of gastric bacteria in antacid-treated patients: a frequent cause of postoperative colonisation of the airway. Lancet. 1982 Jan 30; 1(8266):242-5.
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  33. Geiger K, Hedley-Whyte J. Problems with equipment in oxygen therapy. Int Anesthesiol Clin. 1982; 20(3):205-33.
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  34. du Moulin GC, Doyle GO, MacKay J, Hedley-Whyte J. Bacterial fouling of a hospital closed-loop cooling system by Pseudomonas sp. J Clin Microbiol. 1981 Jun; 13(6):1060-5.
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  35. Priebe HJ, Heimann JC, Hedley-Whyte J. Mechanisms of renal dysfunction during positive end-expiratory pressure ventilation. J Appl Physiol. 1981 Mar; 50(3):643-9.
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  36. Priebe HJ, Heimann JC, Hedley-Whyte J. Effects of renal and hepatic venous congestion on renal function in the presence of low and normal cardiac output in dogs. Circ Res. 1980 Dec; 47(6):883-90.
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  37. Hastings PR, Bushnell LS, Skillman JJ, Weintraub RM, Hedley-Whyte J. Cardiorespiratory dynamics during weaning with IMV versus spontaneous ventilation in good-risk cardiac-surgery patients. Anesthesiology. 1980 Nov; 53(5):429-31.
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  38. Bancroft ML, du Moulin GC, Hedley-Whyte J. Hazards of hospital bulk oxygen delivery systems. Anesthesiology. 1980 Jun; 52(6):504-10.
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  39. Laasberg LH, Johnson EE, Hedley-Whyte J. Effect of morphine and naloxone on leu-enkephalin-like immunoreactivity in dogs. J Pharmacol Exp Ther. 1980 Mar; 212(3):496-502.
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  40. Djokovic JL, Hedley-Whyte J. Prediction of outcome of surgery and anesthesia in patients over 80. JAMA. 1979 Nov 23; 242(21):2301-6.
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  41. Feeley TW, Bancroft ML, Brooks RA, Hedley-Whyte J. Potential hazards of compressed gas cylinders: a review. Anesthesiology. 1978 Jan; 48(1):72-4.
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  42. du Moulin GC, Hedley-Whyte J. A plea for moderation in anesthesia standards. AORN J. 1977 Dec; 26(6):1025-6.
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  43. Johnson EE, Hedley-Whyte J, Hall SV. End-respiratory pressure ventilation and sulfobromophthalein sodium excretion in dogs. J Appl Physiol. 1977 Oct; 43(4):714-20.
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  44. Eichhorn JH, Hedley-Whyte J, Steinman TI, Kaufmann JM, Laasbert LH. Renal failure following enflurane anesthesia. Anesthesiology. 1976 Nov; 45(5):557-60.
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  45. Laasberg LH, Hedley-Whyte J, Laver MB. Effect of sodium para-aminosalicylate on oxygen affinity in normal, sickle and fetal human blood. J Pharmacol Exp Ther. 1976 Nov; 199(2):441-53.
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  46. Christoforides C, Hedley-Whyte J. Solubility of 92 in blood with different hemoglobin concentrations at low temperatures. J Appl Physiol. 1976 May; 40(5):815-8.
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  47. Feeley TW, Hedley-Whyte J. Bulk oxygen and nitrous oxide delivery systems: design and dangers. Anesthesiology. 1976 Apr; 44(4):301-5.
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  48. Johnson EE, Hedley-Whyte J. Continuous positive-pressure ventilation and choledochoduodenal flow resistance. J Appl Physiol. 1975 Dec; 39(6):937-42.
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  49. Geiger K, Gallagher ML, Hedley-Whyte J. Cellular distribution and clearance of aerosolized dipalmitoyl lecithin. J Appl Physiol. 1975 Nov; 39(5):759-66.
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  50. Feeley TW, Du Moulin GC, Hedley-Whyte J, Bushnell LS, Gilbert JP, Feingold DS. Aerosol polymyxin and pneumonia in seriously ill patients. N Engl J Med. 1975 Sep 4; 293(10):471-5.
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  51. Feeley TW, Hedley-Whyte J. Weaning from controlled ventilation and supplemental oxygen. N Engl J Med. 1975 Apr 24; 292(17):903-6.
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  52. Klick JM, du Moulin GC, Hedley-Whyte J, Teres D, Bushnell LS, Feingold DS. Prevention of gram-negative bacillary pneumonia using polymyxin aerosol as prophylaxis. II. Effect on the incidence of pneumonia in seriously ill patients. J Clin Invest. 1975 Mar; 55(3):514-9.
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  53. Saubermann AJ, Gallagher ML, Hedley-Whyte ET, Hedley-Whyte J. Cellular and regional localization of pentobarbital-2-14C by radioautography of selected areas of mouse brain at loss and return of withdrawal response. Anesthesiology. 1975 Mar; 42(3):254-66.
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  54. Lang DW, Darrah HK, Hedley-Whyte J, Laasberg LH. Uptake into brain proteins of 35S-methionine during morphine tolerance. J Pharmacol Exp Ther. 1975 Mar; 192(3):521-30.
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  55. Miller MG, Hedley-White J, Weintraub RM, Restall DS, Alexander M. Surgery for cardiogenic shock. Lancet. 1974 Dec 7; 2(7893):1342-5.
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  56. Hall SV, Johnson EE, Hedley-Whyte J. Renal hemodynamics and function with continuous positive-pressure ventilation in dogs. Anesthesiology. 1974 Nov; 41(5):452-61.
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  57. Saubermann AJ, Gallagher ML, Hedley-Whyte J. Uptake, distribution, and anesthetic effect of pentobarbital-2-14C after intravenous injection into mice. Anesthesiology. 1974 Jan; 40(1):41-51.
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  58. Laasberg LH, Hedley-Whyte J. Viscosity of sickle disease and trait blood: changes with anesthesia. J Appl Physiol. 1973 Dec; 35(6):837-43.
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  59. Greenfield S, Teres D, Bushnell LS, Hedley-Whyte J, Feingold DS. Prevention of gram-negative bacillary pneumonia using aerosol polymyxin as prophylaxis. I. Effect on the colonization pattern of the upper respiratory tract of seriously ill patients. J Clin Invest. 1973 Nov; 52(11):2935-40.
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  60. Teres D, Schweers P, Bushnell LS, Hedley-Whyte J, Feingold DS. Sources of Pseudomonas aeruginosa infection in a respiratory-surgical intensive-therapy unit. Lancet. 1973 Feb 24; 1(7800):415-7.
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  61. Becker CM, Malhotra IV, Hedley-Whyte J. The distribution of radiofrequency current and burns. Anesthesiology. 1973 Feb; 38(2):106-22.
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  62. Darrah HK, Hedley-Whyte J. Rapid incorporation of palmitate into lung: site and metabolic fate. J Appl Physiol. 1973 Feb; 34(2):205-13.
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  63. Leuwenkroon-Strosberg E, Laasberg LH, Hedley-Whyte J. Myosin conformation and enzymatic activity: effect of chloroform, diethyl ether and halothane on optical rotatory dispersion and APTase. Biochim Biophys Acta. 1973 Jan 25; 295(1):178-87.
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  64. Woo SW, Hedley-Whyte J. Oxygen therapy: the titration of a potentially dangerous drug. Brit J Hosp Med. 1973; 9:487-490.
  65. Johnson EE, Hedley-Whyte J. Continuous positive-pressure ventilation and portal flow in dogs with pulmonary edema. J Appl Physiol. 1972 Sep; 33(3):385-9.
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  66. Woo SW, Hedley-Whyte J. Macrophage accumulation and pulmonary edema due to thoracotomy and lung over inflation. J Appl Physiol. 1972 Jul; 33(1):14-21.
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  67. Zervas NT, Hedley-Whyte J. Successful treatment of cerebral herniation in five patients. N Engl J Med. 1972 May 18; 286(20):1075-7.
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  68. Skillman JJ, Hedley-Whyte J, Pallotta JA. Cardiorespiratory, metabolic and endocrine changes after hemorrhage in man. Ann Surg. 1971 Dec; 174(6):911-22.
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  69. Laasberg LH, Hedley-Whyte J. Optical rotatory dispersion of hemoglobin and polypeptides. Effect of halothane. J Biol Chem. 1971 Aug 10; 246(15):4886-93.
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  70. Darrah HK, Hedley-Whyte J, Hedley-Whyte ET. RADIOAUTOGRAPHY OF CHOLESTEROL IN LUNG : An Assessment of Different Tissue Processing Techniques. J Cell Biol. 1971 May 1; 49(2):345-61.
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  71. Darrah HK, Hedley-Whyte J. Distribution of cholesterol in lung. J Appl Physiol. 1971 Jan; 30(1):78-90.
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  72. Hedley-Whyte J. Causes of pulmonary oxygen toxicity. N Engl J Med. 1970 Dec 31; 283(27):1518-9.
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  73. Woo SW, Berlin D, Büch U, Hedley-Whyte J. Altered perfusion, ventilation, anesthesia and lung-surface forces in dogs. Anesthesiology. 1970 Oct; 33(4):411-8.
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  74. Laasberg LH, Hedley-Whyte J. Halothane solubility in blood and solutions of plasma proteins: effects of temperature, protein composition and hemoglobin concentration. Anesthesiology. 1970 Apr; 32(4):351-6.
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  75. Crossman PF, Bushnell LS, Hedley-Whyte J. Dead space during artificial ventilation: gas compression and mechanical dead space. J Appl Physiol. 1970 Jan; 28(1):94-7.
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  76. Skillman JJ, Hedley-Whyte J, Pallotta JA. Hormonal, fuel, and respiratory relationships after acute blood loss in man. Surg Forum. 1970; 21:23-5.
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  77. Christoforides C, Hedley-Whyte J. Effect of temperature and hemoglobin concentration on solubility of O2 in blood. J Appl Physiol. 1969 Nov; 27(5):592-6.
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  78. Skillman JJ, Bushnell LS, Hedley-Whyte J. Peritonitis and respiratory failure after abdominal operations. Ann Surg. 1969 Jul; 170(1):122-7.
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  79. Woo SW, Berlin D, Hedley-Whyte J. Surfactant function and anesthetic agents. J Appl Physiol. 1969 May; 26(5):571-7.
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  80. Christoforides C, Hedley-Whyte J. Supersaturation of blood with O2. J Appl Physiol. 1969 Feb; 26(2):239-40.
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  81. Darrah HK, Hedley-Whyte J. Abnormalities in lung chemistry. Anesth Analg. 1969 Jan-Feb; 48(1):148-65.
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  82. Hedley-Whyte J, Laasberg LH. Ethchlorvynol poisoning: gas liquid chromatography in management. Anesthesiology. 1969 Jan; 30(1):107-11.
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  83. Christoforides C, Laasberg LH, Hedley-Whyte J. Effect of temperature on solubility of O2 in human plasma. J Appl Physiol. 1969 Jan; 26(1):56-60.
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  84. Hedley-Whyte J. Control of the uptake of oxygen. N Engl J Med. 1968 Nov 21; 279(21):1152-8.
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  85. Hedley-Whyte J, Winter PM. Oxygen therapy. Clin Pharmacol Ther. 1967 Sep-Oct; 8(5):696-737.
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  86. Suwa K, Hedley-Whyte J, Bendixen HH. Circulation and physiologic dead space changes on controlling the ventilation of dogs. J Appl Physiol. 1966 Nov; 21(6):1855-9.
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  87. Hedley-Whyte J, Pontoppidan H, Morris MJ. The response of patients with respiratory failure and cardiopulmonary disease to different levels of constant volume ventilation. J Clin Invest. 1966 Oct; 45(10):1543-54.
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  88. Bushnell LS, Pontoppidan H, Hedley-Whyte J, Bendixen HH. Efficiency of different types of ventilation in long-term respiratory care: mechanical versus spontaneous. Anesth Analg. 1966 Sep-Oct; 45(5):696-703.
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  89. Corning H, Hedley-Whyte J, Austen WG. Correlation of blood gas abnormalities and hemodynamic events following cardiac surgery. Ann Thorac Surg. 1966; 2(6):783-790.
  90. HEDLEY-WHYTE J, PONTOPPIDAN H, LAVER MB, HALLOWELL P, BENDIXEN HH. ARTERIAL OXYGENATION DURING HYPOTHERMIA. Anesthesiology. 1965 Sep-Oct; 26:595-602.
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  91. SLATER EM, NILSSON SE, LEAKE DL, PARRY WL, LAVER MB, HEDLEY-WHYTE J, BENDIXEN HH. ARTERIAL OXYGEN TENSION MEASUREMENTS DURING NITROUS OXIDE-OXYGEN ANESTHESIA. Anesthesiology. 1965 Sep-Oct; 26:642-7.
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  92. PONTOPPIDAN H, HEDLEY-WHYTE J, BENDIZEN HH, LAVER MB, RADFORD EP. VENTILATION AND OXYGEN REQUIREMENTS DURING PROLONGED ARTIFICIAL VENTILATION IN PATIENTS WITH RESPIRATORY FAILURE. N Engl J Med. 1965 Aug 19; 273:401-9.
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  93. Hedley-Whyte J, Radford EP. Nomogram for temperature correction or electrode calibration during PO2 measurements. J Appl Physiol. 1965 Jul; 20(4):785-6.
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  94. HALLOWELL P, HEDLEY-WHYTE J, AUSTEN WG, LAVER MB. OXYGENATION DURING CLOSED MITRAL VALVULOTOMY. J Thorac Cardiovasc Surg. 1965 Jul; 50:42-9.
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  95. HEDLEY-WHYTE J, CORNING H, LAVER MB, AUSTEN WG, BENDIXEN HH. PULMONARY VENTILATION-PERFUSION RELATIONS AFTER HEART VALVE REPLACEMENT OF REPAIR IN MAN. J Clin Invest. 1965 Mar; 44:406-16.
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  96. HEDLEY-WHYTE J, LAVER MB. O2 SOLUBILITY IN BLOOD AND TEMPERATURE CORRECTION FACTORS FOR PO2. J Appl Physiol. 1964 Sep; 19:901-6.
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  97. BENDIXEN HH, BULLWINKEL B, HEDLEY-WHYTE J, LAVER MB. ATELECTASIS AND SHUNTING DURING SPONTANEOUS VENTILATION IN ANESTHETIZED PATIENTS. Anesthesiology. 1964 May-Jun; 25:297-301.
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  98. HEDLEY-WHYTE J, LAVER MB, BENDIXEN HH. EFFECT OF CHANGES IN TIDAL VENTILATION ON PHYSIOLOGIC SHUNTING. Am J Physiol. 1964 Apr; 206:891-7.
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  99. BENDIXEN HH, HEDLEY-WHYTE J, LAVER MB. IMPAIRED OXYGENATION IN SURGICAL PATIENTS DURING GENERAL ANESTHESIA WITH CONTROLLED VENTILATION. A CONCEPT OF ATELECTASIS. N Engl J Med. 1963 Nov 7; 269:991-6.
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