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Dora M. Kovacs, PH.D.

TitleAssociate Professor of Neurology
InstitutionMassachusetts General Hospital
DepartmentNeurology
AddressMassachusetts General Hospital
Genetics & Aging Research Unit, Rm 3010
114 16th Street
Charlestown MA 02129
Phone617/726-3668
Fax617/724-1823

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Gautam V, D'Avanzo C, Hebisch M, Kovacs DM, Kim DY. BACE1 activity regulates cell surface contactin-2 levels. Mol Neurodegener. 2014; 9(1):4.
    View in: PubMed
  2. Bhattacharyya R, Barren C, Kovacs DM. Palmitoylation of amyloid precursor protein regulates amyloidogenic processing in lipid rafts. J Neurosci. 2013 Jul 3; 33(27):11169-83.
    View in: PubMed
  3. Dong Y, Wu X, Zhang G, Xu Z, Zhang Y, Gautam V, Kovacs DM, Wu A, Yue Y, Xie Z. Isoflurane Facilitates Synaptic NMDA Receptor Endocytosis in Mice Primary Neurons. Curr Mol Med. 2013 May 1; 13(4):488-98.
    View in: PubMed
  4. Sachse CC, Kim YH, Agsten M, Huth T, Alzheimer C, Kovacs DM, Kim DY. BACE1 and presenilin/?-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels. FASEB J. 2013 Jun; 27(6):2458-67.
    View in: PubMed
  5. Kim DY, Kovacs DM. Surface trafficking of sodium channels in cells and in hippocampal slices. Methods Mol Biol. 2011; 793:351-61.
    View in: PubMed
  6. Haapasalo A, Kovacs DM. The many substrates of presenilin/?-secretase. J Alzheimers Dis. 2011; 25(1):3-28.
    View in: PubMed
  7. Kim DY, Gersbacher MT, Inquimbert P, Kovacs DM. Reduced sodium channel Na(v)1.1 levels in BACE1-null mice. J Biol Chem. 2011 Mar 11; 286(10):8106-16.
    View in: PubMed
  8. Gersbacher MT, Kim DY, Bhattacharyya R, Kovacs DM. Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit. Mol Neurodegener. 2010; 5:61.
    View in: PubMed
  9. Kovacs DM, Gersbacher MT, Kim DY. Alzheimer's secretases regulate voltage-gated sodium channels. Neurosci Lett. 2010 Dec 10; 486(2):68-72.
    View in: PubMed
  10. Huttunen HJ, Havas D, Peach C, Barren C, Duller S, Xia W, Frosch MP, Hutter-Paier B, Windisch M, Kovacs DM. The acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice. J Neuropathol Exp Neurol. 2010 Aug; 69(8):777-88.
    View in: PubMed
  11. Bhattacharyya R, Kovacs DM. ACAT inhibition and amyloid beta reduction. Biochim Biophys Acta. 2010 Aug; 1801(8):960-5.
    View in: PubMed
  12. Vassar R, Kovacs DM, Yan R, Wong PC. The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential. J Neurosci. 2009 Oct 14; 29(41):12787-94.
    View in: PubMed
  13. Huttunen HJ, Peach C, Bhattacharyya R, Barren C, Pettingell W, Hutter-Paier B, Windisch M, Berezovska O, Kovacs DM. Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway. FASEB J. 2009 Nov; 23(11):3819-28.
    View in: PubMed
  14. Huttunen HJ, Puglielli L, Ellis BC, MacKenzie Ingano LA, Kovacs DM. Novel N-terminal cleavage of APP precludes Abeta generation in ACAT-defective AC29 cells. J Mol Neurosci. 2009 Jan; 37(1):6-15.
    View in: PubMed
  15. Huttunen HJ, Kovacs DM. ACAT as a drug target for Alzheimer's disease. Neurodegener Dis. 2008; 5(3-4):212-4.
    View in: PubMed
  16. Huttunen HJ, Guénette SY, Peach C, Greco C, Xia W, Kim DY, Barren C, Tanzi RE, Kovacs DM. HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation. J Biol Chem. 2007 Sep 21; 282(38):28285-95.
    View in: PubMed
  17. Kim DY, Carey BW, Wang H, Ingano LA, Binshtok AM, Wertz MH, Pettingell WH, He P, Lee VM, Woolf CJ, Kovacs DM. BACE1 regulates voltage-gated sodium channels and neuronal activity. Nat Cell Biol. 2007 Jul; 9(7):755-64.
    View in: PubMed
  18. Huttunen HJ, Greco C, Kovacs DM. Knockdown of ACAT-1 reduces amyloidogenic processing of APP. FEBS Lett. 2007 Apr 17; 581(8):1688-92.
    View in: PubMed
  19. Haapasalo A, Kim DY, Carey BW, Turunen MK, Pettingell WH, Kovacs DM. Presenilin/gamma-secretase-mediated cleavage regulates association of leukocyte-common antigen-related (LAR) receptor tyrosine phosphatase with beta-catenin. J Biol Chem. 2007 Mar 23; 282(12):9063-72.
    View in: PubMed
  20. Carey BW, Kim DY, Kovacs DM. Presenilin/gamma-secretase and alpha-secretase-like peptidases cleave human MHC Class I proteins. Biochem J. 2007 Jan 1; 401(1):121-7.
    View in: PubMed
  21. Zhang M, Haapasalo A, Kim DY, Ingano LA, Pettingell WH, Kovacs DM. Presenilin/gamma-secretase activity regulates protein clearance from the endocytic recycling compartment. FASEB J. 2006 Jun; 20(8):1176-8.
    View in: PubMed
  22. Kovacs I, Lentini KM, Ingano LM, Kovacs DM. Presenilin 1 forms aggresomal deposits in response to heat shock. J Mol Neurosci. 2006; 29(1):9-19.
    View in: PubMed
  23. Puglielli L, Friedlich AL, Setchell KD, Nagano S, Opazo C, Cherny RA, Barnham KJ, Wade JD, Melov S, Kovacs DM, Bush AI. Alzheimer disease beta-amyloid activity mimics cholesterol oxidase. J Clin Invest. 2005 Sep; 115(9):2556-63.
    View in: PubMed
  24. Kim DY, Ingano LA, Carey BW, Pettingell WH, Kovacs DM. Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration. J Biol Chem. 2005 Jun 17; 280(24):23251-61.
    View in: PubMed
  25. Hutter-Paier B, Huttunen HJ, Puglielli L, Eckman CB, Kim DY, Hofmeister A, Moir RD, Domnitz SB, Frosch MP, Windisch M, Kovacs DM. The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease. Neuron. 2004 Oct 14; 44(2):227-38.
    View in: PubMed
  26. Xie Z, Romano DM, Kovacs DM, Tanzi RE. Effects of RNA interference-mediated silencing of gamma-secretase complex components on cell sensitivity to caspase-3 activation. J Biol Chem. 2004 Aug 13; 279(33):34130-7.
    View in: PubMed
  27. Puglielli L, Ellis BC, Ingano LA, Kovacs DM. Role of acyl-coenzyme a: cholesterol acyltransferase activity in the processing of the amyloid precursor protein. J Mol Neurosci. 2004; 24(1):93-6.
    View in: PubMed
  28. Xie Z, Moir RD, Romano DM, Tesco G, Kovacs DM, Tanzi RE. Hypocapnia induces caspase-3 activation and increases Abeta production. Neurodegener Dis. 2004; 1(1):29-37.
    View in: PubMed
  29. Puglielli L, Tanzi RE, Kovacs DM. Alzheimer's disease: the cholesterol connection. Nat Neurosci. 2003 Apr; 6(4):345-51.
    View in: PubMed
  30. Puglielli L, Ellis BC, Saunders AJ, Kovacs DM. Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis. J Biol Chem. 2003 May 30; 278(22):19777-83.
    View in: PubMed
  31. Kimberly WT, Kovacs DM, Walsh D, Lashuel H, Lemere CA. The 8th International Conference on Alzheimer's Disease and Related Disorders, July 20-25, 2002, Stockholm, Sweden. Amyloid. 2003 Mar; 10(1):51-61.
    View in: PubMed
  32. Kim DY, Ingano LA, Kovacs DM. Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage. J Biol Chem. 2002 Dec 20; 277(51):49976-81.
    View in: PubMed
  33. Kovacs D, Mahon J, Palmer RL. Chewing and spitting out food among eating-disordered patients. Int J Eat Disord. 2002 Jul; 32(1):112-5.
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  34. Puglielli L, Konopka G, Pack-Chung E, Ingano LA, Berezovska O, Hyman BT, Chang TY, Tanzi RE, Kovacs DM. Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. Nat Cell Biol. 2001 Oct; 3(10):905-12.
    View in: PubMed
  35. Puglielli L, Kovacs DM. Alzheimer disease: 100 years later. Rev Med Chil. 2001 May; 129(5):569-75.
    View in: PubMed
  36. Kovacs DM. alpha2-macroglobulin in late-onset Alzheimer's disease. Exp Gerontol. 2000 Jul; 35(4):473-9.
    View in: PubMed
  37. Abbenante G, Kovacs DM, Leung DL, Craik DJ, Tanzi RE, Fairlie DP. Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site. Biochem Biophys Res Commun. 2000 Feb 5; 268(1):133-5.
    View in: PubMed
  38. Ingano LA, Lentini KM, Kovacs I, Tanzi RE, Kovacs DM. Cytoplasmic presenilin aggregates in proteasome inhibitor-treated cells. Ann N Y Acad Sci. 2000; 920:259-60.
    View in: PubMed
  39. Kovacs DM, Mancini R, Henderson J, Na SJ, Schmidt SD, Kim TW, Tanzi RE. Staurosporine-induced activation of caspase-3 is potentiated by presenilin 1 familial Alzheimer's disease mutations in human neuroglioma cells. J Neurochem. 1999 Dec; 73(6):2278-85.
    View in: PubMed
  40. Kovacs DM, Tanzi RE. Monogenic determinants of familial Alzheimer's disease: presenilin-1 mutations. Cell Mol Life Sci. 1998 Sep; 54(9):902-9.
    View in: PubMed
  41. Kim TW, Pettingell WH, Jung YK, Kovacs DM, Tanzi RE. Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science. 1997 Jul 18; 277(5324):373-6.
    View in: PubMed
  42. Seeger M, Nordstedt C, Petanceska S, Kovacs DM, Gouras GK, Hahne S, Fraser P, Levesque L, Czernik AJ, George-Hyslop PS, Sisodia SS, Thinakaran G, Tanzi RE, Greengard P, Gandy S. Evidence for phosphorylation and oligomeric assembly of presenilin 1. Proc Natl Acad Sci U S A. 1997 May 13; 94(10):5090-4.
    View in: PubMed
  43. Kovacs DM, Fausett HJ, Page KJ, Kim TW, Moir RD, Merriam DE, Hollister RD, Hallmark OG, Mancini R, Felsenstein KM, Hyman BT, Tanzi RE, Wasco W. Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nat Med. 1996 Feb; 2(2):224-9.
    View in: PubMed
  44. Tanzi RE, Kovacs DM, Kim TW, Moir RD, Guenette SY, Wasco W. The gene defects responsible for familial Alzheimer's disease. Neurobiol Dis. 1996; 3(3):159-68.
    View in: PubMed
  45. Kovacs DM, Wasco W, Witherby J, Felsenstein KM, Brunel F, Roeder RG, Tanzi RE. The upstream stimulatory factor functionally interacts with the Alzheimer amyloid beta-protein precursor gene. Hum Mol Genet. 1995 Sep; 4(9):1527-33.
    View in: PubMed
  46. Wasco W, Pettingell WP, Jondro PD, Schmidt SD, Gurubhagavatula S, Rodes L, DiBlasi T, Romano DM, Guenette SY, Kovacs DM, et al. Familial Alzheimer's chromosome 14 mutations. Nat Med. 1995 Sep; 1(9):848.
    View in: PubMed
  47. Kovacs DM, Kaplan BB. Discordant estimates of heterologous promoter activity as determined by reporter gene mRNA levels and enzyme activity. Biochem Biophys Res Commun. 1992 Dec 15; 189(2):912-8.
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  48. Miner LL, Pandalai SP, Weisberg EP, Sell SL, Kovacs DM, Kaplan BB. Cold-induced alterations in the binding of adrenomedullary nuclear proteins to the promoter region of the tyrosine hydroxylase gene. J Neurosci Res. 1992 Sep; 33(1):10-8.
    View in: PubMed
  49. LeBlanc AC, Kovacs DM, Chen HY, Villaré F, Tykocinski M, Autilio-Gambetti L, Gambetti P. Role of amyloid precursor protein (APP): study with antisense transfection of human neuroblastoma cells. J Neurosci Res. 1992 Apr; 31(4):635-45.
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  50. Palmert MR, Podlisny MB, Golde TE, Cohen ML, Kovacs DM, Tanzi RE, Gusella JF, Whitehouse PJ, Witker DS, Oltersdorf T, et al. Analysis of the beta-amyloid protein precursor of Alzheimer's disease: mRNAs and protein products. Adv Neurol. 1990; 51:181-4.
    View in: PubMed
  51. Palmert MR, Podlisny MB, Golde TE, Cohen ML, Kovacs DM, Tanzi RE, Gusella JF, Whitehouse PJ, Witker DS, Oltersdorf T, et al. The beta amyloid protein precursor: mRNAs, membrane-associated forms, and soluble derivatives. Prog Clin Biol Res. 1989; 317:971-84.
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  52. Autilio-Gambetti L, Morandi A, Kovacs DM, Tabaton M, Schaetzle B, Hauer C, Groger RK, Tykocinski ML, Perry G, Greenberg BD, et al. Amyloid precursor protein in cell cultures: a 130 kDa polypeptide. Prog Clin Biol Res. 1989; 317:985-90.
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  53. Autilio-Gambetti L, Morandi A, Tabaton M, Schaetzle B, Kovacs D, Perry G, Sharma S, Cornette J, Greenberg B, Gambetti P. The amyloid percursor protein of Alzheimer disease is expressed as a 130 kDa polypeptide in various cultured cell types. FEBS Lett. 1988 Dec 5; 241(1-2):94-8.
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  54. Palmert MR, Golde TE, Cohen ML, Kovacs DM, Tanzi RE, Gusella JF, Usiak MF, Younkin LH, Younkin SG. Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease. Science. 1988 Aug 26; 241(4869):1080-4.
    View in: PubMed
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