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Cammie Lesser, M.D., Ph.D.

TitleAssociate Professor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
Infectious Disease Unit - GRJ 5
65 Landsdowne St
Cambridge MA 02139
Phone617/768-8349
Fax617/768-8738

 Mentoring 
 completed student projects
Drag'nDrop into Viral Inclusions: A Novel Visualization Platform for Detecting Protein Interactions
Summer, 06/11/07 - 08/10/07
Drag'nDrop into Viral Inclusions: A novel visualization platform for detecting protein interactions
Summer, 06/15/07 - 08/15/07
Investigations into the roles of Shigella IpaJ using yeast functional genomic assays
Summer, 06/11/07 - 08/10/07

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Costa SC, Schmitz AM, Jahufar FF, Boyd JD, Cho MY, Glicksman MA, Lesser CF. A new means to identify type 3 secreted effectors: functionally interchangeable class IB chaperones recognize a conserved sequence. MBio. 2012; 3(1).
    View in: PubMed
  2. de Groot JC, Schlüter K, Carius Y, Quedenau C, Vingadassalom D, Faix J, Weiss SM, Reichelt J, Standfuss-Gabisch C, Lesser CF, Leong JM, Heinz DW, Büssow K, Stradal TE. Structural basis for complex formation between human IRSp53 and the translocated intimin receptor Tir of enterohemorrhagic E. coli. Structure. 2011 Sep 7; 19(9):1294-306.
    View in: PubMed
  3. Archuleta TL, Du Y, English CA, Lory S, Lesser C, Ohi MD, Ohi R, Spiller BW. The Chlamydia effector chlamydial outer protein N (CopN) sequesters tubulin and prevents microtubule assembly. J Biol Chem. 2011 Sep 30; 286(39):33992-8.
    View in: PubMed
  4. Lesser CF, Leong JM. Bacterial scaffolds assemble novel higher-order complexes to reengineer eukaryotic cell processes. Sci Signal. 2011; 4(180):pe32.
    View in: PubMed
  5. Durand-Heredia JM, Yu HH, De Carlo S, Lesser CF, Janakiraman A. Identification and characterization of ZapC, a stabilizer of the FtsZ ring in Escherichia coli. J Bacteriol. 2011 Mar; 193(6):1405-13.
    View in: PubMed
  6. Sukumaran B, Mastronunzio JE, Narasimhan S, Fankhauser S, Uchil PD, Levy R, Graham M, Colpitts TM, Lesser CF, Fikrig E. Anaplasma phagocytophilum AptA modulates Erk1/2 signalling. Cell Microbiol. 2011 Jan; 13(1):47-61.
    View in: PubMed
  7. McCoy MW, Marré ML, Lesser CF, Mecsas J. The C-terminal tail of Yersinia pseudotuberculosis YopM is critical for interacting with RSK1 and for virulence. Infect Immun. 2010 Jun; 78(6):2584-98.
    View in: PubMed
  8. Heindl JE, Saran I, Yi CR, Lesser CF, Goldberg MB. Requirement for formin-induced actin polymerization during spread of Shigella flexneri. Infect Immun. 2010 Jan; 78(1):193-203.
    View in: PubMed
  9. Schmitz AM, Morrison MF, Agunwamba AO, Nibert ML, Lesser CF. Protein interaction platforms: visualization of interacting proteins in yeast. Nat Methods. 2009 Jul; 6(7):500-2.
    View in: PubMed
  10. Siggers, K.A. and Lesser, C.F. Shigella IpgB1, a RhoGTPase mimic, localizes to lipid rafts in both yeast and mammalian cells. Cellular Microbiology. 2008; in review.
  11. Fukazawa, A., Alsono, C., Kurachi, K. Gupta, S., Lesser, C., McCormick, B.A. and Reinecker, H-C. . GEF-H1 Mediated Control of NOD1 Dependent NF-κB Activation by Shigella Effectors. PLoS Pathogens, in press. 2008.
  12. Fukazawa A, Alonso C, Kurachi K, Gupta S, Lesser CF, McCormick BA, Reinecker HC. GEF-H1 mediated control of NOD1 dependent NF-kappaB activation by Shigella effectors. PLoS Pathog. 2008 Nov; 4(11):e1000228.
    View in: PubMed
  13. Huang, J., Lesser, C.F., and Lory, S. . The essential role of the CopN protein for Chlamydia pneumoniae intracellular growth. 10.1038/nature07355. 2008.
  14. Huang J, Lesser CF, Lory S. The essential role of the CopN protein in Chlamydia pneumoniae intracellular growth. Nature. 2008 Nov 6; 456(7218):112-5.
    View in: PubMed
  15. Siggers KA, Lesser CF. The Yeast Saccharomyces cerevisiae: a versatile model system for the identification and characterization of bacterial virulence proteins. Cell Host Microbe. 2008 Jul 17; 4(1):8-15.
    View in: PubMed
  16. Siggers, K.A and Lesser, C.F. . The Yeast Saccharoyces cerevisiae: A versatile Model System for the Identification and Characterization of Bacterial Virulence Proteins. Cell, Host and Microbe. 2008; 4(1):8-15.
  17. Slagowski, N.L., Kramer, R.W., Morrison, M.F., LaBaer and Lesser, CF . A functional genomic yeast screen to identify pathogenic bacterial proteins. 2008; 4(1):e9.
  18. Slagowski NL, Kramer RW, Morrison MF, LaBaer J, Lesser CF. A functional genomic yeast screen to identify pathogenic bacterial proteins. PLoS Pathog. 2008 Jan; 4(1):e9.
    View in: PubMed
  19. Kramer RW, Slagowski NL, Eze NA, Giddings KS, Morrison MF, Siggers KA, Starnbach MN, Lesser CF. Yeast functional genomic screens lead to identification of a role for a bacterial effector in innate immunity regulation. PLoS Pathog. 2007 Feb; 3(2):e21.
    View in: PubMed
  20. Lesser CF, Miller SI. . Salmonellosis. Harrison's Principles of Internal Medicine. 2004.
  21. Gottlieb GS, Lesser CF, Holmes KK, Wald A. Disseminated sporotrichosis associated with treatment with immunosuppressants and tumor necrosis factor-alpha antagonists. Clin Infect Dis. 2003 Sep 15; 37(6):838-40.
    View in: PubMed
  22. Gottlieb, G.S., Lesser, C.F., Holmes K.K. and Wald, A. . Disseminated Sporotrichosis associated with treatment with immunosuppressants and TNF alpha antagonists. CID. 2003; 37(6):838-40.
  23. Shone SM, Ferrao PN, Lesser CR, Norris DE, Glass GE. Analysis of mosquito vector species abundances in Maryland using geographic information systems. Ann N Y Acad Sci. 2001 Dec; 951:364-8.
    View in: PubMed
  24. Lesser CF, Miller SI. Expression of microbial virulence proteins in Saccharomyces cerevisiae models mammalian infection. EMBO J. 2001 Apr 17; 20(8):1840-9.
    View in: PubMed
  25. Lesser, C.F. and Miller, S.I. . Expression of microbial virulence factors in Saccharomyces cerevisiae models mammalian infection. . EMBO Journal. 2001; 20(8):1840-9.
  26. Lesser, C.F. and Miller, S.I. . Tractable Saccharomyces cerevisiae is model system for studying pathogenic bacterial proteins: introducing bacterial virulence proteins into yeast provides valuable insights about their interactions with host components. ASM News. 2001; 67(9):448-455.
  27. Lesser CF, Miller SI. . Salmonellosis. Harrison's Principles of Internal Medicine. 2001; 975-8.
  28. Lesser CF, Scherer CA, Miller SI. Rac, ruffle and rho: orchestration of Salmonella invasion. Trends Microbiol. 2000 Apr; 8(4):151-2.
    View in: PubMed
  29. Lesser, C.F., Scherer, C.A and Miller, S.I. . Rac, Ruffle and Rho: Orchestration of Salmonella ruffling. Trends in Microbiology. 2000; 8(4):151-2.
  30. Lesser CF, Guthrie C. Mutations in U6 snRNA that alter splice site specificity: implications for the active site. Science. 1993 Dec 24; 262(5142):1982-8.
    View in: PubMed
  31. Lesser CF, Guthrie C. Mutational analysis of pre-mRNA splicing in Saccharomyces cerevisiae using a sensitive new reporter gene, CUP1. Genetics. 1993 Apr; 133(4):851-63.
    View in: PubMed
  32. Andrews DW, Perara E, Lesser C, Lingappa VR. Sequences beyond the cleavage site influence signal peptide function. J Biol Chem. 1988 Oct 25; 263(30):15791-8.
    View in: PubMed
  33. Leong JM, Nunes-Düby SE, Oser AB, Lesser CF, Youderian P, Susskind MM, Landy A. Structural and regulatory divergence among site-specific recombination genes of lambdoid phage. J Mol Biol. 1986 Jun 20; 189(4):603-16.
    View in: PubMed
  34. Leong JM, Nunes-Düby S, Lesser CF, Youderian P, Susskind MM, Landy A. The phi 80 and P22 attachment sites. Primary structure and interaction with Escherichia coli integration host factor. J Biol Chem. 1985 Apr 10; 260(7):4468-77.
    View in: PubMed
  35. Leong, J.M., Nunes-Duby, S., Lesser, C.F., Youderin, P., Susskind, M.M. and Landy, A. . The Ø80 and P22 attachment sites. Primary structure and interaction with Escherichia coli integration host factor. Journal of Biological Chemistry. 1985; 260(7):4468-77.
  36. Leong JM, Nunes-Duby S, Oser A, Lesser CF, Youderian P, Susskind MM, Landy A. Site-specific recombination systems of phages phi 80 and P22: binding sites of integration host factor and recombination-induced mutations. Cold Spring Harb Symp Quant Biol. 1984; 49:707-14.
    View in: PubMed
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