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Gregory Michael Miller, Ph.D.

TitleAssociate Professor of Psychiatry
InstitutionHarvard Medical School
DepartmentPsychiatry
AddressNew England Primate Research Center
Division of Neurochemistry
1 Pine Hill Dr
Southborough MA 01772
Phone508/624-8023
Fax508/624-8166

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Goswami DB, Ogawa LM, Ward JM, Miller GM, Vallender EJ. Large-scale polymorphism discovery in macaque G-protein coupled receptors. BMC Genomics. 2013; 14:703.
    View in: PubMed
  2. Lynch LJ, Sullivan KA, Vallender EJ, Rowlett JK, Platt DM, Miller GM. Trace amine associated receptor 1 modulates behavioral effects of ethanol. Subst Abuse. 2013; 7:117-26.
    View in: PubMed
  3. Chen GL, Miller GM. Extensive alternative splicing of the repressor element silencing transcription factor linked to cancer. PLoS One. 2013; 8(4):e62217.
    View in: PubMed
  4. Chen GL, Miller GM. Tryptophan hydroxylase-2: An emerging therapeutic target for stress disorders. Biochem Pharmacol. 2013 May 1; 85(9):1227-33.
    View in: PubMed
  5. Vallender EJ, Miller GM. Nonhuman primate models in the genomic era: a paradigm shift. ILAR J. 2013 Jan; 54(2):154-65.
    View in: PubMed
  6. Chen GL, Miller GM. Advances in tryptophan hydroxylase-2 gene expression regulation: new insights into serotonin-stress interaction and clinical implications. Am J Med Genet B Neuropsychiatr Genet. 2012 Mar; 159B(2):152-71.
    View in: PubMed
  7. Miller GM. Avenues for the development of therapeutics that target trace amine associated receptor 1 (TAAR1). J Med Chem. 2012 Mar 8; 55(5):1809-14.
    View in: PubMed
  8. Achat-Mendes C, Lynch LJ, Sullivan KA, Vallender EJ, Miller GM. Augmentation of methamphetamine-induced behaviors in transgenic mice lacking the trace amine-associated receptor 1. Pharmacol Biochem Behav. 2012 Apr; 101(2):201-7.
    View in: PubMed
  9. Panas MW, Xie Z, Panas HN, Hoener MC, Vallender EJ, Miller GM. Trace amine associated receptor 1 signaling in activated lymphocytes. J Neuroimmune Pharmacol. 2012 Dec; 7(4):866-76.
    View in: PubMed
  10. Lewin AH, Miller GM, Gilmour B. Trace amine-associated receptor 1 is a stereoselective binding site for compounds in the amphetamine class. Bioorg Med Chem. 2011 Dec 1; 19(23):7044-8.
    View in: PubMed
  11. Westmoreland SV, Annamalai L, Lentz MR, Ratai EM, Assaf B, Boisvert K, Huynh T, Vallender EJ, Miller GM, Madras BK, Gonzalez RG. Growth-associated protein-43 and ephrin B3 induction in the brain of adult SIV-infected rhesus macaques. J Neurovirol. 2011 Oct; 17(5):455-68.
    View in: PubMed
  12. Karmacharya R, Lynn SK, Demarco S, Ortiz A, Wang X, Lundy MY, Xie Z, Cohen BM, Miller GM, Buttner EA. Behavioral effects of clozapine: involvement of trace amine pathways in C. elegans and M. musculus. Brain Res. 2011 Jun 1; 1393:91-9.
    View in: PubMed
  13. Miller GM. The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity. J Neurochem. 2011 Jan; 116(2):164-76.
    View in: PubMed
  14. Panas HN, Lynch LJ, Vallender EJ, Xie Z, Chen GL, Lynn SK, Scanlan TS, Miller GM. Normal thermoregulatory responses to 3-iodothyronamine, trace amines and amphetamine-like psychostimulants in trace amine associated receptor 1 knockout mice. J Neurosci Res. 2010 Jul; 88(9):1962-9.
    View in: PubMed
  15. Vallender EJ, Xie Z, Westmoreland SV, Miller GM. Functional evolution of the trace amine associated receptors in mammals and the loss of TAAR1 in dogs. BMC Evol Biol. 2010; 10:51.
    View in: PubMed
  16. Vallender EJ, Rüedi-Bettschen D, Miller GM, Platt DM. A pharmacogenetic model of naltrexone-induced attenuation of alcohol consumption in rhesus monkeys. Drug Alcohol Depend. 2010 Jun 1; 109(1-3):252-6.
    View in: PubMed
  17. Chen GL, Novak MA, Meyer JS, Kelly BJ, Vallender EJ, Miller GM. TPH2 5'- and 3'-regulatory polymorphisms are differentially associated with HPA axis function and self-injurious behavior in rhesus monkeys. Genes Brain Behav. 2010 Apr; 9(3):335-47.
    View in: PubMed
  18. Chen GL, Novak MA, Meyer JS, Kelly BJ, Vallender EJ, Miller GM. The effect of rearing experience and TPH2 genotype on HPA axis function and aggression in rhesus monkeys: a retrospective analysis. Horm Behav. 2010 Feb; 57(2):184-91.
    View in: PubMed
  19. Kanthaswamy S, Capitanio JP, Dubay CJ, Ferguson B, Folks T, Ha JC, Hotchkiss CE, Johnson ZP, Katze MG, Kean LS, Kubisch HM, Lank S, Lyons LA, Miller GM, Nylander J, O'Connor DH, Palermo RE, Smith DG, Vallender EJ, Wiseman RW, Rogers J. Resources for genetic management and genomics research on non-human primates at the National Primate Research Centers (NPRCs). J Med Primatol. 2009 Oct; 38 Suppl 1:17-23.
    View in: PubMed
  20. Ferguson B, Capitanio J, Folks T, Hotchkiss C, Johnson Z, Kean L, Kubisch HM, Lank S, Lyons L, Miller GM, Nylander J, O'Connor D, Vallender EJ, Wiseman R. Resource brief: the National Non-Human Primate DNA Bank. Methods. 2009 Sep; 49(1):3-4.
    View in: PubMed
  21. Vallender EJ, Lynch L, Novak MA, Miller GM. Polymorphisms in the 3' UTR of the serotonin transporter are associated with cognitive flexibility in rhesus macaques. Am J Med Genet B Neuropsychiatr Genet. 2009 Jun 5; 150B(4):467-75.
    View in: PubMed
  22. Xie Z, Miller GM. Trace amine-associated receptor 1 as a monoaminergic modulator in brain. Biochem Pharmacol. 2009 Nov 1; 78(9):1095-104.
    View in: PubMed
  23. Xie Z, Miller GM. A receptor mechanism for methamphetamine action in dopamine transporter regulation in brain. J Pharmacol Exp Ther. 2009 Jul; 330(1):316-25.
    View in: PubMed
  24. Chen GL, Miller GM. 5'-Untranslated region of the tryptophan hydroxylase-2 gene harbors an asymmetric bidirectional promoter but not internal ribosome entry site in vitro. Gene. 2009 Apr 15; 435(1-2):53-62.
    View in: PubMed
  25. Xie Z, Vallender EJ, Yu N, Kirstein SL, Yang H, Bahn ME, Westmoreland SV, Miller GM. Cloning, expression, and functional analysis of rhesus monkey trace amine-associated receptor 6: evidence for lack of monoaminergic association. J Neurosci Res. 2008 Nov 15; 86(15):3435-46.
    View in: PubMed
  26. Chen GL, Miller GM. Rhesus monkey tryptophan hydroxylase-2 coding region haplotypes affect mRNA stability. Neuroscience. 2008 Aug 13; 155(2):485-91.
    View in: PubMed
  27. Vallender EJ, Priddy CM, Hakim S, Yang H, Chen GL, Miller GM. Functional variation in the 3' untranslated region of the serotonin transporter in human and rhesus macaque. Genes Brain Behav. 2008 Aug; 7(6):690-7.
    View in: PubMed
  28. Vallender EJ, Priddy CM, Chen GL, Miller GM. Human expression variation in the mu-opioid receptor is paralleled in rhesus macaque. Behav Genet. 2008 Jul; 38(4):390-5.
    View in: PubMed
  29. Xie Z, Westmoreland SV, Miller GM. Modulation of monoamine transporters by common biogenic amines via trace amine-associated receptor 1 and monoamine autoreceptors in human embryonic kidney 293 cells and brain synaptosomes. J Pharmacol Exp Ther. 2008 May; 325(2):629-40.
    View in: PubMed
  30. Verrico CD, Lynch L, Fahey MA, Fryer AK, Miller GM, Madras BK. MDMA-induced impairment in primates: antagonism by a selective norepinephrine or serotonin, but not by a dopamine/norepinephrine transport inhibitor. J Psychopharmacol. 2008 Mar; 22(2):187-202.
    View in: PubMed
  31. Xie Z, Miller GM. Beta-phenylethylamine alters monoamine transporter function via trace amine-associated receptor 1: implication for modulatory roles of trace amines in brain. J Pharmacol Exp Ther. 2008 May; 325(2):617-28.
    View in: PubMed
  32. Lee AS, Gutiérrez-Arcelus M, Perry GH, Vallender EJ, Johnson WE, Miller GM, Korbel JO, Lee C. Analysis of copy number variation in the rhesus macaque genome identifies candidate loci for evolutionary and human disease studies. Hum Mol Genet. 2008 Apr 15; 17(8):1127-36.
    View in: PubMed
  33. Chen GL, Vallender EJ, Miller GM. Functional characterization of the human TPH2 5' regulatory region: untranslated region and polymorphisms modulate gene expression in vitro. Hum Genet. 2008 Jan; 122(6):645-57.
    View in: PubMed
  34. Zhang J, Vinuela A, Neely MH, Hallett PJ, Grant SG, Miller GM, Isacson O, Caron MG, Yao WD. Inhibition of the dopamine D1 receptor signaling by PSD-95. J Biol Chem. 2007 May 25; 282(21):15778-89.
    View in: PubMed
  35. Xie Z, Miller GM. Trace amine-associated receptor 1 is a modulator of the dopamine transporter. J Pharmacol Exp Ther. 2007 Apr; 321(1):128-36.
    View in: PubMed
  36. Xie Z, Westmoreland SV, Bahn ME, Chen GL, Yang H, Vallender EJ, Yao WD, Madras BK, Miller GM. Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro. J Pharmacol Exp Ther. 2007 Apr; 321(1):116-27.
    View in: PubMed
  37. Newman RM, Hall L, Connole M, Chen GL, Sato S, Yuste E, Diehl W, Hunter E, Kaur A, Miller GM, Johnson WE. Balancing selection and the evolution of functional polymorphism in Old World monkey TRIM5alpha. Proc Natl Acad Sci U S A. 2006 Dec 12; 103(50):19134-9.
    View in: PubMed
  38. Madras BK, Xie Z, Lin Z, Jassen A, Panas H, Lynch L, Johnson R, Livni E, Spencer TJ, Bonab AA, Miller GM, Fischman AJ. Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. J Pharmacol Exp Ther. 2006 Nov; 319(2):561-9.
    View in: PubMed
  39. Kumar R, Orsoni S, Norman L, Verma AS, Tirado G, Giavedoni LD, Staprans S, Miller GM, Buch SJ, Kumar A. Chronic morphine exposure causes pronounced virus replication in cerebral compartment and accelerated onset of AIDS in SIV/SHIV-infected Indian rhesus macaques. Virology. 2006 Oct 10; 354(1):192-206.
    View in: PubMed
  40. Chen GL, Novak MA, Hakim S, Xie Z, Miller GM. Tryptophan hydroxylase-2 gene polymorphisms in rhesus monkeys: association with hypothalamic-pituitary-adrenal axis function and in vitro gene expression. Mol Psychiatry. 2006 Oct; 11(10):914-28.
    View in: PubMed
  41. Jassen AK, Yang H, Miller GM, Calder E, Madras BK. Receptor regulation of gene expression of axon guidance molecules: implications for adaptation. Mol Pharmacol. 2006 Jul; 70(1):71-7.
    View in: PubMed
  42. Xiao D, Miller GM, Jassen A, Westmoreland SV, Pauley D, Madras BK. Ephrin/Eph receptor expression in brain of adult nonhuman primates: implications for neuroadaptation. Brain Res. 2006 Jan 5; 1067(1):67-77.
    View in: PubMed
  43. Verrico CD, Miller GM, Madras BK. MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment. Psychopharmacology (Berl). 2007 Jan; 189(4):489-503.
    View in: PubMed
  44. Jassen AK, Brown JM, Panas HN, Miller GM, Xiao D, Madras BK. Variants of the primate vesicular monoamine transporter-2. Brain Res Mol Brain Res. 2005 Oct 3; 139(2):251-7.
    View in: PubMed
  45. Yatin SM, Miller GM, Madras BK. Dopamine and norepinephrine transporter-dependent c-Fos production in vitro: relevance to neuroadaptation. J Neurosci Methods. 2005 Apr 15; 143(1):69-78.
    View in: PubMed
  46. Miller GM, Verrico CD, Jassen A, Konar M, Yang H, Panas H, Bahn M, Johnson R, Madras BK. Primate trace amine receptor 1 modulation by the dopamine transporter. J Pharmacol Exp Ther. 2005 Jun; 313(3):983-94.
    View in: PubMed
  47. Madras BK, Miller GM, Fischman AJ. The dopamine transporter and attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005 Jun 1; 57(11):1397-409.
    View in: PubMed
  48. Miller GM and Madras BK. . The Laboratory Primate. SA Wolfe-Coote, editor. Genetic Variations and Phenotypic Associations Common to Rhesus Monkeys and Humans. 2005.
  49. Miller GM, Bendor J, Tiefenbacher S, Yang H, Novak MA, Madras BK. A mu-opioid receptor single nucleotide polymorphism in rhesus monkey: association with stress response and aggression. Mol Psychiatry. 2004 Jan; 9(1):99-108.
    View in: PubMed
  50. Madras BK, Fahey MA, Miller GM, De La Garza R, Goulet M, Spealman RD, Meltzer PC, George SR, O'Dowd BF, Bonab AA, Livni E, Fischman AJ. Non-amine-based dopamine transporter (reuptake) inhibitors retain properties of amine-based progenitors. Eur J Pharmacol. 2003 Oct 31; 479(1-3):41-51.
    View in: PubMed
  51. Yatin SM, Miller GM, Norton C, Madras BK. Dopamine transporter-dependent induction of C-Fos in HEK cells. Synapse. 2002 Jul; 45(1):52-65.
    View in: PubMed
  52. Madras BK, Miller GM, Fischman AJ. The dopamine transporter: relevance to attention deficit hyperactivity disorder (ADHD). Behav Brain Res. 2002 Mar 10; 130(1-2):57-63.
    View in: PubMed
  53. Miller GM, Madras BK. Polymorphisms in the 3'-untranslated region of human and monkey dopamine transporter genes affect reporter gene expression. Mol Psychiatry. 2002; 7(1):44-55.
    View in: PubMed
  54. Goulet M, Miller GM, Bendor J, Liu S, Meltzer PC, Madras BK. Non-amines, drugs without an amine nitrogen, potently block serotonin transport: novel antidepressant candidates? Synapse. 2001 Dec 1; 42(3):129-40.
    View in: PubMed
  55. Miller GM, Yatin SM, De La Garza R, Goulet M, Madras BK. Cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivity. Brain Res Mol Brain Res. 2001 Feb 19; 87(1):124-43.
    View in: PubMed
  56. Miller GM, Zhang X, Klibanski A. . Diagnosis and management of pituitary tumors. In: Kovacs, K. editors. Pituitary tumors: future perspectives. 2001; 462-466.
  57. Miller GM, De La Garza R, Novak MA, Madras BK. Single nucleotide polymorphisms distinguish multiple dopamine transporter alleles in primates: implications for association with attention deficit hyperactivity disorder and other neuropsychiatric disorders. Mol Psychiatry. 2001 Jan; 6(1):50-8.
    View in: PubMed
  58. Madras BK, Miller GM, Meltzer PC, Brownell AL, Fischman AJ. Molecular and regional targets of cocaine in primate brain: liberation from prosaic views. Addict Biol. 2000 Jul 1; 5(3):351-9.
    View in: PubMed
  59. Madras B, Miller GM, De La Garza R, Dougherty DD, Bonab AA, Spencer TJ, Rauch SL, Fischman AJ. . 6th International World Congress for Biomed.Sci. Brain Imaging of the dopamine transporter in ADHD. 2000; 113.
  60. Gibson MJ, Wu TJ, Miller GM, Silverman AJ. What nature's knockout teaches us about GnRH activity: hypogonadal mice and neuronal grafts. Horm Behav. 1997 Jun; 31(3):212-20.
    View in: PubMed
  61. Miller GM, Alexander JM, Klibanski A. Gonadotropin-releasing hormone messenger RNA expression in gonadotroph tumors and normal human pituitary. J Clin Endocrinol Metab. 1996 Jan; 81(1):80-3.
    View in: PubMed
  62. Miller GM, Silverman AJ, Rogers MC, Gibson MJ. Neuromodulation of transplanted gonadotropin-releasing hormone neurons in male and female hypogonadal mice with preoptic area brain grafts. Biol Reprod. 1995 Mar; 52(3):572-83.
    View in: PubMed
  63. Miller GM, Gibson MJ. Opioidergic modulation of N-methyl-D,L-aspartic-acid-stimulated LH release in young adult but not older male mice. Neuroendocrinology. 1994 Mar; 59(3):277-84.
    View in: PubMed
  64. Silverman AJ, Roberts JL, Dong KW, Miller GM, Gibson MJ. Intrahypothalamic injection of a cell line secreting gonadotropin-releasing hormone results in cellular differentiation and reversal of hypogonadism in mutant mice. Proc Natl Acad Sci U S A. 1992 Nov 15; 89(22):10668-72.
    View in: PubMed
  65. Wu TJ, Segal AZ, Miller GM, Gibson MJ, Silverman AJ. FOS expression in gonadotropin-releasing hormone neurons: enhancement by steroid treatment and mating. Endocrinology. 1992 Nov; 131(5):2045-50.
    View in: PubMed
  66. Gibson MJ, Saitoh Y, Miller GM, Silverman A-J. . Modes of Action of GnRH and GnRH analogs. Functional GnRH neuronal transplants in the hypogonadal mouse. 1992; 144-157.
  67. Gibson MJ, Miller GM, Silverman AJ. Pulsatile luteinizing hormone secretion in normal female mice and in hypogonadal female mice with preoptic area implants. Endocrinology. 1991 Feb; 128(2):965-71.
    View in: PubMed
  68. Miller GM, Silverman A-J, Roberts JL, Dong KW, Gibson MJ. . Cell Transplantation. Functional assessment of intrahypothalamic implants of immortalized gonadotropin-releasing hormone secreting cells in female hypogonadal mice. 3(2):251-257.
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