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Eric Joseph Rubin, PH.D., M.D.

TitleProfessor of Immunology and Infectious Diseases
InstitutionHarvard School of Public Health
DepartmentImmunology and Infectious Diseases
AddressHarvard Inst of Medicine
Microbiology and Immunobiology, HIM 1048
4 Blackfan Cir
Boston MA 02115
Phone617/432-3335
Other Positions
TitleProfessor of Immunology and Infectious Diseases
InstitutionHarvard School of Public Health
DepartmentImmunology and Infectious Diseases

TitleAssistant Professor of Medicine (Microbiology and Molecular Genetics)
InstitutionBrigham and Women's Hospital
DepartmentMedicine
DivisionChanning Lab


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Sassetti CM, Rubin EJ. Relics of selection in the mycobacterial genome. Nat Genet. 2010 Jun; 42(6):476-8.
    View in: PubMed
  2. Ioerger TR, Feng Y, Ganesula K, Chen X, Dobos KM, Fortune S, Jacobs WR, Mizrahi V, Parish T, Rubin E, Sassetti C, Sacchettini JC. Variation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories. J Bacteriol. 2010 Jul; 192(14):3645-53.
    View in: PubMed
  3. Dutton RJ, Wayman A, Wei JR, Rubin EJ, Beckwith J, Boyd D. Inhibition of bacterial disulfide bond formation by the anticoagulant warfarin. Proc Natl Acad Sci U S A. 2010 Jan 5; 107(1):297-301.
    View in: PubMed
  4. Bitter W, Houben EN, Bottai D, Brodin P, Brown EJ, Cox JS, Derbyshire K, Fortune SM, Gao LY, Liu J, Gey van Pittius NC, Pym AS, Rubin EJ, Sherman DR, Cole ST, Brosch R. Systematic genetic nomenclature for type VII secretion systems. PLoS Pathog. 2009 Oct; 5(10):e1000507.
    View in: PubMed
  5. Siegrist MS, Unnikrishnan M, McConnell MJ, Borowsky M, Cheng TY, Siddiqi N, Fortune SM, Moody DB, Rubin EJ. Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition. Proc Natl Acad Sci U S A. 2009 Nov 3; 106(44):18792-7.
    View in: PubMed
  6. Murry JP, Pandey AK, Sassetti CM, Rubin EJ. Phthiocerol dimycocerosate transport is required for resisting interferon-gamma-independent immunity. J Infect Dis. 2009 Sep 1; 200(5):774-82.
    View in: PubMed
  7. Ranjbar S, Boshoff HI, Mulder A, Siddiqi N, Rubin EJ, Goldfeld AE. HIV-1 replication is differentially regulated by distinct clinical strains of Mycobacterium tuberculosis. PLoS One. 2009; 4(7):e6116.
    View in: PubMed
  8. Rubin EJ. The granuloma in tuberculosis--friend or foe? N Engl J Med. 2009 Jun 4; 360(23):2471-3.
    View in: PubMed
  9. Siegrist MS, Rubin EJ. Phage transposon mutagenesis. Methods Mol Biol. 2009; 465:311-23.
    View in: PubMed
  10. Pandey AK, Raman S, Proff R, Joshi S, Kang CM, Rubin EJ, Husson RN, Sassetti CM. Nitrile-inducible gene expression in mycobacteria. Tuberculosis (Edinb). 2009 Jan; 89(1):12-6.
    View in: PubMed
  11. Wei JR, Rubin EJ. The many roads to essential genes. Tuberculosis (Edinb). 2008 Aug; 88 Suppl 1:S19-24.
    View in: PubMed
  12. Hett EC, Rubin EJ. Bacterial growth and cell division: a mycobacterial perspective. Microbiol Mol Biol Rev. 2008 Mar; 72(1):126-56, table of contents.
    View in: PubMed
  13. Philips JA, Porto MC, Wang H, Rubin EJ, Perrimon N. ESCRT factors restrict mycobacterial growth. Proc Natl Acad Sci U S A. 2008 Feb 26; 105(8):3070-5.
    View in: PubMed
  14. Hett EC, Chao MC, Deng LL, Rubin EJ. A mycobacterial enzyme essential for cell division synergizes with resuscitation-promoting factor. PLoS Pathog. 2008 Feb 15; 4(2):e1000001.
    View in: PubMed
  15. Rengarajan J, Murphy E, Park A, Krone CL, Hett EC, Bloom BR, Glimcher LH, Rubin EJ. Mycobacterium tuberculosis Rv2224c modulates innate immune responses. Proc Natl Acad Sci U S A. 2008 Jan 8; 105(1):264-9.
    View in: PubMed
  16. Murry JP, Sassetti CM, Lane JM, Xie Z, Rubin EJ. Transposon site hybridization in Mycobacterium tuberculosis. Methods Mol Biol. 2008; 416:45-59.
    View in: PubMed
  17. Sacchettini JC, Rubin EJ, Freundlich JS. Drugs versus bugs: in pursuit of the persistent predator Mycobacterium tuberculosis. Nat Rev Microbiol. 2008 Jan; 6(1):41-52.
    View in: PubMed
  18. Zolotarev AS, Unnikrishnan M, Shmukler BE, Clark JS, Vandorpe DH, Grigorieff N, Rubin EJ, Alper SL. Increased sulfate uptake by E. coli overexpressing the SLC26-related SulP protein Rv1739c from Mycobacterium tuberculosis. Comp Biochem Physiol A Mol Integr Physiol. 2008 Mar; 149(3):255-66.
    View in: PubMed
  19. Farrow MF, Rubin EJ. Function of a mycobacterial major facilitator superfamily pump requires a membrane-associated lipoprotein. J Bacteriol. 2008 Mar; 190(5):1783-91.
    View in: PubMed
  20. Hett EC, Chao MC, Steyn AJ, Fortune SM, Deng LL, Rubin EJ. A partner for the resuscitation-promoting factors of Mycobacterium tuberculosis. Mol Microbiol. 2007 Nov; 66(3):658-68.
    View in: PubMed
  21. Fortune SM, Rubin EJ. The complex relationship between mycobacteria and macrophages: it's not all bliss. Cell Host Microbe. 2007 Jul 12; 2(1):5-6.
    View in: PubMed
  22. Charity JC, Costante-Hamm MM, Balon EL, Boyd DH, Rubin EJ, Dove SL. Twin RNA polymerase-associated proteins control virulence gene expression in Francisella tularensis. PLoS Pathog. 2007 Jun; 3(6):e84.
    View in: PubMed
  23. Sassetti CM, Rubin EJ. The open book of infectious diseases. Nat Med. 2007 Mar; 13(3):279-80.
    View in: PubMed
  24. Sebastian S, Dillon ST, Lynch JG, Blalock LT, Balon E, Lee KT, Comstock LE, Conlan JW, Rubin EJ, Tzianabos AO, Kasper DL. A defined O-antigen polysaccharide mutant of Francisella tularensis live vaccine strain has attenuated virulence while retaining its protective capacity. Infect Immun. 2007 May; 75(5):2591-602.
    View in: PubMed
  25. Joshi SM, Pandey AK, Capite N, Fortune SM, Rubin EJ, Sassetti CM. Characterization of mycobacterial virulence genes through genetic interaction mapping. Proc Natl Acad Sci U S A. 2006 Aug 1; 103(31):11760-5.
    View in: PubMed
  26. Hung DT, Rubin EJ. Chemical biology and bacteria: not simply a matter of life or death. Curr Opin Chem Biol. 2006 Aug; 10(4):321-6.
    View in: PubMed
  27. Diaz R, Siddiqi N, Rubin EJ. Detecting genetic variability among different Mycobacterium tuberculosis strains using DNA microarrays technology. Tuberculosis (Edinb). 2006 May-Jul; 86(3-4):314-8.
    View in: PubMed
  28. Lane JM, Rubin EJ. Scaling down: a PCR-based method to efficiently screen for desired knockouts in a high density Mycobacterium tuberculosis picked mutant library. Tuberculosis (Edinb). 2006 May-Jul; 86(3-4):310-3.
    View in: PubMed
  29. Fortune SM, Chase MR, Rubin EJ. Dividing oceans into pools: strategies for the global analysis of bacterial genes. Microbes Infect. 2006 May; 8(6):1631-6.
    View in: PubMed
  30. Nardell EA, Rubin EJ. Once upon a time. . . improved intermittent therapy for tuberculosis--fact or fable? Am J Respir Crit Care Med. 2005 Dec 1; 172(11):1361-2.
    View in: PubMed
  31. Xie Z, Siddiqi N, Rubin EJ. Differential antibiotic susceptibilities of starved Mycobacterium tuberculosis isolates. Antimicrob Agents Chemother. 2005 Nov; 49(11):4778-80.
    View in: PubMed
  32. Murry J, Sassetti CM, Moreira J, Lane J, Rubin EJ. A new site-specific integration system for mycobacteria. Tuberculosis (Edinb). 2005 Sep-Nov; 85(5-6):317-23.
    View in: PubMed
  33. Murry JP, Rubin EJ. New genetic approaches shed light on TB virulence. Trends Microbiol. 2005 Aug; 13(8):366-72.
    View in: PubMed
  34. Philips JA, Rubin EJ, Perrimon N. Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection. Science. 2005 Aug 19; 309(5738):1251-3.
    View in: PubMed
  35. Agaisse H, Burrack LS, Philips JA, Rubin EJ, Perrimon N, Higgins DE. Genome-wide RNAi screen for host factors required for intracellular bacterial infection. Science. 2005 Aug 19; 309(5738):1248-51.
    View in: PubMed
  36. Kaufmann SH, Cole ST, Mizrahi V, Rubin E, Nathan C. Mycobacterium tuberculosis and the host response. J Exp Med. 2005 Jun 6; 201(11):1693-7.
    View in: PubMed
  37. Rengarajan J, Bloom BR, Rubin EJ. Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages. Proc Natl Acad Sci U S A. 2005 Jun 7; 102(23):8327-32.
    View in: PubMed
  38. Rubin EJ. Toward a new therapy for tuberculosis. N Engl J Med. 2005 Mar 3; 352(9):933-4.
    View in: PubMed
  39. Rengarajan J, Sassetti CM, Naroditskaya V, Sloutsky A, Bloom BR, Rubin EJ. The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria. Mol Microbiol. 2004 Jul; 53(1):275-82.
    View in: PubMed
  40. Fortune SM, Solache A, Jaeger A, Hill PJ, Belisle JT, Bloom BR, Rubin EJ, Ernst JD. Mycobacterium tuberculosis inhibits macrophage responses to IFN-gamma through myeloid differentiation factor 88-dependent and -independent mechanisms. J Immunol. 2004 May 15; 172(10):6272-80.
    View in: PubMed
  41. Sassetti CM, Rubin EJ. Genetic requirements for mycobacterial survival during infection. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12989-94.
    View in: PubMed
  42. Sampson SL, Rengarajan J, Rubin EJ. Bacterial genomics and vaccine design. Expert Rev Vaccines. 2003 Jun; 2(3):437-45.
    View in: PubMed
  43. Sassetti CM, Boyd DH, Rubin EJ. Genes required for mycobacterial growth defined by high density mutagenesis. Mol Microbiol. 2003 Apr; 48(1):77-84.
    View in: PubMed
  44. Eichbaum Q, Rubin EJ. Tuberculosis. Advances in laboratory diagnosis and drug susceptibility testing. Am J Clin Pathol. 2002 Dec; 118 Suppl:S3-17.
    View in: PubMed
  45. Chiang SL, Rubin EJ. Construction of a mariner-based transposon for epitope-tagging and genomic targeting. Gene. 2002 Aug 21; 296(1-2):179-85.
    View in: PubMed
  46. Sassetti C, Rubin EJ. Genomic analyses of microbial virulence. Curr Opin Microbiol. 2002 Feb; 5(1):27-32.
    View in: PubMed
  47. Akerley BJ, Rubin EJ, Novick VL, Amaya K, Judson N, Mekalanos JJ. A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae. Proc Natl Acad Sci U S A. 2002 Jan 22; 99(2):966-71.
    View in: PubMed
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