Douglas B. Cowan, Ph.D.
|Title||Associate Professor of Anaesthesia|
|Institution||Children's Hospital Boston|
Anesthesiology (Enders 320)
300 Longwood Ave
Boston MA 02115
Our laboratory studies the cardiovascular system with an emphasis on combining tissue engineering and stem cell biology to improve heart function.
Current projects in our laboratory include the following:
Cardiac Conduction through Engineered Tissue – We are engineering tissues to act as electrical conduits for use in pediatric patients with complete heart block. Ultimately, we hope to provide a realistic alternative or accessory treatment to conventional cardiac pacemaker implantation in children.
Adult Stem Cell Culture – We are developing methods to expand and control the fate of tissue-specific stem cells to determine their regenerative potential for the treatment of cardiac and skeletal muscle disorders. Our studies are designed to advance cell-based therapies for a variety of human diseases.
Mitochondrial Transplantation – This collaborative project is focused on providing a clinically-relevant treatment for myocardial infarction in adults. Accordingly, we and our colleagues are injecting autologous mitochondria into the heart to decrease the extent of damage and enhance functional recovery.
Molecular Biology, Cell Biology, Cardiac Physiology, Biochemistry, Electrophysiology, Stem Cell Biology, Confocal Microscopy, Fluorescence Microscopy, Electron Microscopy, Protein Chemistry, Cell Culture, Bioengineering, Optical Surface Mapping, Cardiovascular Surgery, Tissue Engineering.
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