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Last Name
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Joseph David Brain, S.D.Hyg.

TitleCecil K and Philip Drinker Professor of Environmental Physiology
InstitutionHarvard School of Public Health
DepartmentEH - Molecular+Integrative Phys Sci Prog
AddressHarvard School of Public Health
Building 1, Room 1308A
665 Huntington Ave
Boston MA 02115
Phone617/432-1272
Other Positions
TitleCecil K. and Philip Drinker Professor of Environmental Physiology, Harvard School of Public Health
InstitutionFaculty of Arts & Sciences
DepartmentGen Ed


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Molina RM, Schaider LA, Donaghey TC, Shine JP, Brain JD. Mineralogy affects geoavailability, bioaccessibility and bioavailability of zinc. Environ Pollut. 2013 Nov; 182:217-24.
    View in: PubMed
  2. Pirela S, Molina R, Watson C, Cohen JM, Bello D, Demokritou P, Brain J. Effects of copy center particles on the lungs: a toxicological characterization using a Balb/c mouse model. Inhal Toxicol. 2013 Aug; 25(9):498-508.
    View in: PubMed
  3. Grondin Y, Cotanche DA, Manneberg O, Molina R, Treviño-Villarreal JH, Sepulveda R, Clifford R, Bortoni ME, Forsberg S, Labrecque B, Altshul L, Brain JD, Jackson RL, Rogers RA. Pulmonary delivery of d-methionine is associated with an increase in ALCAR and glutathione in cochlear fluids. Hear Res. 2013 Apr; 298:93-103.
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  4. Demokritou P, Gass S, Pyrgiotakis G, Cohen JM, Goldsmith W, McKinney W, Frazer D, Ma J, Schwegler-Berry D, Brain J, Castranova V. An in vivo and in vitro toxicological characterisation of realistic nanoscale CeO2 inhalation exposures. Nanotoxicology. 2013 Dec; 7:1338-50.
    View in: PubMed
  5. Brain JD, Kavet R, Valberg PA. Observations on power-line magnetic fields associated with asthma in children. Arch Pediatr Adolesc Med. 2012 Jan; 166(1):97-8; author reply 98-9.
    View in: PubMed
  6. Mendivil CO, Teeter JG, Finch GL, Schwartz PF, Riese RJ, Brain JD. Trough insulin levels in bronchoalveolar lavage following inhaled human insulin (Exubera) in patients with diabetes mellitus. Diabetes Technol Ther. 2012 Jan; 14(1):50-8.
    View in: PubMed
  7. Sotiriou GA, Diaz E, Long MS, Godleski J, Brain J, Pratsinis SE, Demokritou P. A novel platform for pulmonary and cardiovascular toxicological characterization of inhaled engineered nanomaterials. Nanotoxicology. 2012 Sep; 6(6):680-90.
    View in: PubMed
  8. Brain JD, Christophi CA. Heterogeneity of hemoglobin H disease in childhood. N Engl J Med. 2011 May 26; 364(21):2069-70; author reply 2071-2.
    View in: PubMed
  9. Molina RM, Phattanarudee S, Kim J, Thompson K, Wessling-Resnick M, Maher TJ, Brain JD. Ingestion of Mn and Pb by rats during and after pregnancy alters iron metabolism and behavior in offspring. Neurotoxicology. 2011 Aug; 32(4):413-22.
    View in: PubMed
  10. Fabian P, Brain J, Houseman EA, Gern J, Milton DK. Origin of exhaled breath particles from healthy and human rhinovirus-infected subjects. J Aerosol Med Pulm Drug Deliv. 2011 Jun; 24(3):137-47.
    View in: PubMed
  11. Kim J, Molina RM, Donaghey TC, Buckett PD, Brain JD, Wessling-Resnick M. Influence of DMT1 and iron status on inflammatory responses in the lung. Am J Physiol Lung Cell Mol Physiol. 2011 Apr; 300(4):L659-65.
    View in: PubMed
  12. Thompson KJ, Molina RM, Donaghey T, Savaliya S, Schwob JE, Brain JD. Manganese uptake and distribution in the brain after methyl bromide-induced lesions in the olfactory epithelia. Toxicol Sci. 2011 Mar; 120(1):163-72.
    View in: PubMed
  13. Patton JS, Brain JD, Davies LA, Fiegel J, Gumbleton M, Kim KJ, Sakagami M, Vanbever R, Ehrhardt C. The particle has landed--characterizing the fate of inhaled pharmaceuticals. J Aerosol Med Pulm Drug Deliv. 2010 Dec; 23 Suppl 2:S71-87.
    View in: PubMed
  14. Bellows CF, Molina RM, Brain JD. Diminished organelle motion in murine Kupffer cells during the erythrocytic stage of malaria. J R Soc Interface. 2011 May 6; 8(58):711-9.
    View in: PubMed
  15. Krishnan R, Klumpers DD, Park CY, Rajendran K, Trepat X, van Bezu J, van Hinsbergh VW, Carman CV, Brain JD, Fredberg JJ, Butler JP, van Nieuw Amerongen GP. Substrate stiffening promotes endothelial monolayer disruption through enhanced physical forces. Am J Physiol Cell Physiol. 2011 Jan; 300(1):C146-54.
    View in: PubMed
  16. Demokritou P, Büchel R, Molina RM, Deloid GM, Brain JD, Pratsinis SE. Development and characterization of a Versatile Engineered Nanomaterial Generation System (VENGES) suitable for toxicological studies. Inhal Toxicol. 2010 Dec; 22 Suppl 2:107-16.
    View in: PubMed
  17. Lichtenstein JH, Molina RM, Donaghey TC, Amuzie CJ, Pestka JJ, Coull BA, Brain JD. Pulmonary responses to Stachybotrys chartarum and its toxins: mouse strain affects clearance and macrophage cytotoxicity. Toxicol Sci. 2010 Jul; 116(1):113-21.
    View in: PubMed
  18. Berntsen P, Park CY, Rothen-Rutishauser B, Tsuda A, Sager TM, Molina RM, Donaghey TC, Alencar AM, Kasahara DI, Ericsson T, Millet EJ, Swenson J, Tschumperlin DJ, Butler JP, Brain JD, Fredberg JJ, Gehr P, Zhou EH. Biomechanical effects of environmental and engineered particles on human airway smooth muscle cells. J R Soc Interface. 2010 Jun 6; 7 Suppl 3:S331-40.
    View in: PubMed
  19. Brain JD, Kreyling W, Gehr P. To the editors: express concern about the recent paper by Song et al. Eur Respir J. 2010 Jan; 35(1):226-7.
    View in: PubMed
  20. Thompson K, Molina RM, Donaghey T, Brain JD, Wessling-Resnick M. Iron absorption by Belgrade rat pups during lactation. Am J Physiol Gastrointest Liver Physiol. 2007 Sep; 293(3):G640-4.
    View in: PubMed
  21. Brain JD. Inhalation, deposition, and fate of insulin and other therapeutic proteins. Diabetes Technol Ther. 2007 Jun; 9 Suppl 1:S4-S15.
    View in: PubMed
  22. Trujillo JR, Rogers R, Molina RM, Dangond F, McLane MF, Essex M, Brain JD. Noninfectious entry of HIV-1 into peripheral and brain macrophages mediated by the mannose receptor. Proc Natl Acad Sci U S A. 2007 Mar 20; 104(12):5097-102.
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  23. Molina RM, Brain JD. In vivo comparison of cat alveolar and pulmonary intravascular macrophages: phagocytosis, particle clearance, and cytoplasmic motility. Exp Lung Res. 2007 Mar; 33(2):53-70.
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  24. Hsu YH, Xu X, Terwedow HA, Niu T, Hong X, Wu D, Wang L, Brain JD, Bouxsein ML, Cummings SR, Rosen CJ, Xu X. Large-scale genome-wide linkage analysis for loci linked to BMD at different skeletal sites in extreme selected sibships. J Bone Miner Res. 2007 Feb; 22(2):184-94.
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  25. Thompson K, Molina RM, Brain JD, Wessling-Resnick M. Belgrade rats display liver iron loading. J Nutr. 2006 Dec; 136(12):3010-4.
    View in: PubMed
  26. Thompson K, Molina RM, Donaghey T, Schwob JE, Brain JD, Wessling-Resnick M. Olfactory uptake of manganese requires DMT1 and is enhanced by anemia. FASEB J. 2007 Jan; 21(1):223-30.
    View in: PubMed
  27. Barrero LH, Hsu YH, Terwedow H, Perry MJ, Dennerlein JT, Brain JD, Xu X. Prevalence and physical determinants of low back pain in a rural Chinese population. Spine (Phila Pa 1976). 2006 Nov 1; 31(23):2728-34.
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  28. Zalloua PA, Hsu YH, Terwedow H, Zang T, Wu D, Tang G, Li Z, Hong X, Azar ST, Wang B, Bouxsein ML, Brain J, Cummings SR, Rosen CJ, Xu X. Impact of seafood and fruit consumption on bone mineral density. Maturitas. 2007 Jan 20; 56(1):1-11.
    View in: PubMed
  29. Rosenblum Lichtenstein JH, Molina RM, Donaghey TC, Brain JD. Strain differences influence murine pulmonary responses to Stachybotrys chartarum. Am J Respir Cell Mol Biol. 2006 Oct; 35(4):415-23.
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  30. Heilig EA, Thompson KJ, Molina RM, Ivanov AR, Brain JD, Wessling-Resnick M. Manganese and iron transport across pulmonary epithelium. Am J Physiol Lung Cell Mol Physiol. 2006 Jun; 290(6):L1247-59.
    View in: PubMed
  31. Hsu YH, Venners SA, Terwedow HA, Feng Y, Niu T, Li Z, Laird N, Brain JD, Cummings SR, Bouxsein ML, Rosen CJ, Xu X. Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women. Am J Clin Nutr. 2006 Jan; 83(1):146-54.
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  32. Brain JD, Heilig E, Donaghey TC, Knutson MD, Wessling-Resnick M, Molina RM. Effects of iron status on transpulmonary transport and tissue distribution of Mn and Fe. Am J Respir Cell Mol Biol. 2006 Mar; 34(3):330-7.
    View in: PubMed
  33. Brain JD. Unlocking the opportunity of tight glycaemic control. Inhaled insulin: safety. Diabetes Obes Metab. 2005 Nov; 7 Suppl 1:S14-8.
    View in: PubMed
  34. Hsu YH, Niu T, Terwedow HA, Xu X, Feng Y, Li Z, Brain JD, Rosen CJ, Laird N, Xu X. Variation in genes involved in the RANKL/RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men. Hum Genet. 2006 Jan; 118(5):568-77.
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  35. Feng Y, Hsu YH, Terwedow H, Chen Cz, Xu X, Niu T, Zang T, Wu D, Tang G, Li Z, Hong X, Wang B, Brain JD, Cummings SR, Rosen C, Bouxsein ML, Xu X. Familial aggregation of bone mineral density and bone mineral content in a Chinese population. Osteoporos Int. 2005 Dec; 16(12):1917-23.
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  36. Thompson K, Molina R, Donaghey T, Brain JD, Wessling-Resnick M. The influence of high iron diet on rat lung manganese absorption. Toxicol Appl Pharmacol. 2006 Jan 1; 210(1-2):17-23.
    View in: PubMed
  37. Heilig E, Molina R, Donaghey T, Brain JD, Wessling-Resnick M. Pharmacokinetics of pulmonary manganese absorption: evidence for increased susceptibility to manganese loading in iron-deficient rats. Am J Physiol Lung Cell Mol Physiol. 2005 May; 288(5):L887-93.
    View in: PubMed
  38. Bellows CF, Brain JD. Role of fibronectin in pancreatitis-associated lung injury. Dig Dis Sci. 2003 Aug; 48(8):1445-52.
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  39. Brain JD, Kavet R, McCormick DL, Poole C, Silverman LB, Smith TJ, Valberg PA, Van Etten RA, Weaver JC. Childhood leukemia: electric and magnetic fields as possible risk factors. Environ Health Perspect. 2003 Jun; 111(7):962-70.
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  40. Vandivier RW, Fadok VA, Ogden CA, Hoffmann PR, Brain JD, Accurso FJ, Fisher JH, Greene KE, Henson PM. Impaired clearance of apoptotic cells from cystic fibrosis airways. Chest. 2002 Mar; 121(3 Suppl):89S.
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  41. Vandivier RW, Fadok VA, Hoffmann PR, Bratton DL, Penvari C, Brown KK, Brain JD, Accurso FJ, Henson PM. Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. J Clin Invest. 2002 Mar; 109(5):661-70.
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  42. Long NC, Suh J, Morrow JD, Schiestl RH, Murthy GG, Brain JD, Frei B. Ozone causes lipid peroxidation but little antioxidant depletion in exercising and nonexercising hamsters. J Appl Physiol. 2001 Oct; 91(4):1694-700.
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  43. Trujillo JR, Goletiani NV, Bosch I, Kendrick C, Rogers RA, Trujillo EB, Essex M, Brain JD. T-tropic sequence of the V3 loop is critical for HIV-1 infection of CXCR4-positive colonic HT-29 epithelial cells. J Acquir Immune Defic Syndr. 2000 Sep 1; 25(1):1-10.
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  44. Rao CY, Brain JD, Burge HA. Reduction of pulmonary toxicity of Stachybotrys chartarum spores by methanol extraction of mycotoxins. Appl Environ Microbiol. 2000 Jul; 66(7):2817-21.
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  45. Rao CY, Burge HA, Brain JD. The time course of responses to intratracheally instilled toxic Stachybotrys chartarum spores in rats. Mycopathologia. 2000 Jan; 149(1):27-34.
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  46. Antonini JM, Lawryk NJ, Murthy GG, Brain JD. Effect of welding fume solubility on lung macrophage viability and function in vitro. J Toxicol Environ Health A. 1999 Nov 26; 58(6):343-63.
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  47. Weller E, Long N, Smith A, Williams P, Ravi S, Gill J, Henessey R, Skornik W, Brain J, Kimmel C, Kimmel G, Holmes L, Ryan L. Dose-rate effects of ethylene oxide exposure on developmental toxicity. Toxicol Sci. 1999 Aug; 50(2):259-70.
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  48. Brain JD, Molina RM, DeCamp MM, Warner AE. Effects of a perfluorochemical emulsion on the fate of circulating Pseudomonas aeruginosa. Am J Physiol. 1999 Jun; 276(6 Pt 1):L1037-45.
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  49. Rogers RA, Antonini JM, Brismar H, Lai J, Hesterberg TW, Oldmixon EH, Thevenaz P, Brain JD. In situ microscopic analysis of asbestos and synthetic vitreous fibers retained in hamster lungs following inhalation. Environ Health Perspect. 1999 May; 107(5):367-75.
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  50. Brain JD, Molina RM, DeCamp MM, Warner AE. Pulmonary intravascular macrophages: their contribution to the mononuclear phagocyte system in 13 species. Am J Physiol. 1999 Jan; 276(1 Pt 1):L146-54.
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  51. Frevert CW, Warner AE, Weller E, Brain JD. The effect of endotoxin on in vivo rat alveolar macrophage phagocytosis. Exp Lung Res. 1998 Nov-Dec; 24(6):745-58.
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  52. Antonini JM, Clarke RW, Krishna Murthy GG, Sreekanthan P, Jenkins N, Eagar TW, Brain JD. Freshly generated stainless steel welding fume induces greater lung inflammation in rats as compared to aged fume. Toxicol Lett. 1998 Sep 1; 98(1-2):77-86.
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  53. Trujillo JR, Rogers RA, Brain JD. Shared antigenic epitopes on the V3 loop of HIV-1 gp120 and proteins on activated human T cells. Virology. 1998 Jun 20; 246(1):53-62.
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  54. Brain JD, Long NC, Wolfthal SF, Dumyahn T, Dockery DW. Pulmonary toxicity in hamsters of smoke particles from Kuwaiti oil fires. Environ Health Perspect. 1998 Mar; 106(3):141-6.
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  55. Rees DD, Brain JD, Wohl ME, Humes JL, Mumford RA. Inhibition of neutrophil elastase in CF sputum by L-658,758. J Pharmacol Exp Ther. 1997 Dec; 283(3):1201-6.
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  56. Antonini JM, Krishna Murthy GG, Brain JD. Responses to welding fumes: lung injury, inflammation, and the release of tumor necrosis factor-alpha and interleukin-1 beta. Exp Lung Res. 1997 May-Jun; 23(3):205-27.
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  57. Brown RE, Brain JD, Wang N. The avian respiratory system: a unique model for studies of respiratory toxicosis and for monitoring air quality. Environ Health Perspect. 1997 Feb; 105(2):188-200.
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  58. Antonini JM, Krishna Murthy GG, Rogers RA, Albert R, Ulrich GD, Brain JD. Pneumotoxicity and pulmonary clearance of different welding fumes after intratracheal instillation in the rat. Toxicol Appl Pharmacol. 1996 Sep; 140(1):188-99.
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  59. Brain JD. Environmental lung disease: exposures and mechanisms. Chest. 1996 Mar; 109(3 Suppl):74S-78S.
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  60. Mizgerd JP, Molina RM, Stearns RC, Brain JD, Warner AE. Gadolinium induces macrophage apoptosis. J Leukoc Biol. 1996 Feb; 59(2):189-95.
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  61. Sexton K, Beck BD, Bingham E, Brain JD, DeMarini DM, Hertzberg RC, O'Flaherty EJ, Pounds JG. Chemical mixtures from a public health perspective: the importance of research for informed decision making. Toxicology. 1995 Dec 28; 105(2-3):429-41.
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  62. Mizgerd JP, Kobzik L, Warner AE, Brain JD. Effects of sodium concentration on human neutrophil bactericidal functions. Am J Physiol. 1995 Sep; 269(3 Pt 1):L388-93.
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  63. Rees DD, Brain JD. Effects of cystic fibrosis airway secretions on rat lung: role of neutrophil elastase. Am J Physiol. 1995 Aug; 269(2 Pt 1):L195-202.
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  64. Mizgerd JP, Brain JD. Reactive oxygen species in the killing of Pseudomonas aeruginosa by human leukocytes. Curr Microbiol. 1995 Aug; 31(2):124-8.
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  65. Jimba M, Skornik WA, Killingsworth CR, Long NC, Brain JD, Shore SA. Role of C fibers in physiological responses to ozone in rats. J Appl Physiol. 1995 May; 78(5):1757-63.
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  66. Sweeney TD, Skornik WA, Brain JD, Hatch V, Godleski JJ. Chronic bronchitis alters the pattern of aerosol deposition in the lung. Am J Respir Crit Care Med. 1995 Feb; 151(2 Pt 1):482-8.
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  67. Palitzsch KD, Brain JD, Bynum TE, Szabo S. Lung damage aggravates gastric mucosal lesions induced by ethanol in the rat. Digestion. 1995; 56(3):204-10.
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  68. Rogers RA, Tasat DR, Warner AE, Brain JD. Quantitative recovery of pulmonary intravascular macrophages from sheep lungs. J Leukoc Biol. 1994 Dec; 56(6):692-701.
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  69. Brain JD, Godleski J, Kreyling W. In vivo evaluation of chemical biopersistence of nonfibrous inorganic particles. Environ Health Perspect. 1994 Oct; 102 Suppl 5:119-25.
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  70. Tschaikowsky K, Brain JD. Effects of liposome-encapsulated dichloromethylene diphosphonate on macrophage function and endotoxin-induced mortality. Biochim Biophys Acta. 1994 Jul 21; 1222(3):323-30.
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  71. Lalonde C, Demling R, Brain J, Blanchard J. Smoke inhalation injury in sheep is caused by the particle phase, not the gas phase. J Appl Physiol. 1994 Jul; 77(1):15-22.
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  72. Tschaikowsky K, Brain JD. Staurosporine encapsulated into pH-sensitive liposomes reduces tnf production and increases survival in rat endotoxin shock. Shock. 1994 Jun; 1(6):401-7.
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  73. Warner AE, Mulina RM, Bellows CF, Brain JD. Endotoxemia enhances pulmonary mononuclear cell uptake of circulating particles and pathogens in a species without pulmonary intravascular macrophages. Chest. 1994 Mar; 105(3 Suppl):50S-51S.
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  74. Demling R, Lalonde C, Heron P, Picard L, Blanchard J, Brain J. Effect of increasing the tidal volume of smoke breaths on smoke-induced lung dysfunction. J Appl Physiol. 1994 Jan; 76(1):283-90.
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  75. Niven RW, Kacmarek RM, Brain JD, Peterfreund RA. Small bore nozzle extensions to improve the delivery efficiency of drugs from metered dose inhalers: laboratory evaluation. Am Rev Respir Dis. 1993 Jun; 147(6 Pt 1):1590-4.
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  76. Rose RM, Kobzik L, Dushay K, Wolfthal S, Hondalus M, Metzger M, Stoudemire J, Brain JD, Garnick M, O'Donnell C, et al. The effect of aerosolized recombinant human granulocyte macrophage colony-stimulating factor on lung leukocytes in nonhuman primates. Am Rev Respir Dis. 1992 Nov; 146(5 Pt 1):1279-86.
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  77. Brain JD. Mechanisms, measurement, and significance of lung macrophage function. Environ Health Perspect. 1992 Jul; 97:5-10.
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  78. DeCamp MM, Warner AE, Molina RM, Brain JD. Hepatic versus pulmonary uptake of particles injected into the portal circulation in sheep. Endotoxin escapes hepatic clearance causing pulmonary inflammation. Am Rev Respir Dis. 1992 Jul; 146(1):224-31.
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  79. Brain JD. Short-term in vitro and in vivo bioassays: their role in estimating the toxic potential of inhaled complex mixtures for humans. Cell Biol Toxicol. 1992 Jul-Sep; 8(3):123-32.
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  80. Kharasch VS, Sweeney TD, Fredberg J, Lehr J, Damokosh AI, Avery ME, Brain JD. Pulmonary surfactant as a vehicle for intratracheal delivery of technetium sulfur colloid and pentamidine in hamster lungs. Am Rev Respir Dis. 1991 Oct; 144(4):909-13.
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  81. Blanchard JD, Heyder J, O'Donnell CR, Brain JD. Aerosol-derived lung morphometry: comparisons with a lung model and lung function indexes. J Appl Physiol. 1991 Oct; 71(4):1216-24.
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  82. Anderson PJ, Garshick E, Blanchard JD, Feldman HA, Brain JD. Intersubject variability in particle deposition does not explain variability in responsiveness to methacholine. Am Rev Respir Dis. 1991 Sep; 144(3 Pt 1):649-54.
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  83. Zeltner TB, Sweeney TD, Skornik WA, Feldman HA, Brain JD. Retention and clearance of 0.9-micron particles inhaled by hamsters during rest or exercise. J Appl Physiol. 1991 Mar; 70(3):1137-45.
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  84. Sweeney TD, Leith DE, Brain JD. Restraining hamsters alters their breathing pattern. J Appl Physiol. 1991 Mar; 70(3):1271-6.
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  85. Sweeney TD, Brain JD. Pulmonary deposition: determinants and measurement techniques. Toxicol Pathol. 1991; 19(4 Pt 1):384-97.
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  86. Skornik WA, Brain JD. Effect of sulfur dioxide on pulmonary macrophage endocytosis at rest and during exercise. Am Rev Respir Dis. 1990 Sep; 142(3):655-9.
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  87. Skornik WA, Brain JD. Breathing and lung mechanics in hamsters: effect of pentobarbital anesthesia. J Appl Physiol. 1990 Jun; 68(6):2536-41.
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  88. Kobzik L, Godleski JJ, Brain JD. Selective down-regulation of alveolar macrophage oxidative response to opsonin-independent phagocytosis. J Immunol. 1990 Jun 1; 144(11):4312-9.
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  89. Kreyling WG, Godleski JJ, Kariya ST, Rose RM, Brain JD. In vitro dissolution of uniform cobalt oxide particles by human and canine alveolar macrophages. Am J Respir Cell Mol Biol. 1990 May; 2(5):413-22.
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  90. Kobzik L, Godleski JJ, Brain JD. Oxidative metabolism in the alveolar macrophage: analysis by flow cytometry. J Leukoc Biol. 1990 Apr; 47(4):295-303.
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  91. Sweeney TD, Tryka AF, Brain JD. Effect of exercise on redistribution and clearance of inhaled particles from hamster lungs. J Appl Physiol. 1990 Mar; 68(3):967-72.
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  92. Warner AE, Brain JD. The cell biology and pathogenic role of pulmonary intravascular macrophages. Am J Physiol. 1990 Feb; 258(2 Pt 1):L1-12.
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  93. Anderson PJ, Blanchard JD, Brain JD, Feldman HA, McNamara JJ, Heyder J. Effect of cystic fibrosis on inhaled aerosol boluses. Am Rev Respir Dis. 1989 Nov; 140(5):1317-24.
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  94. Nemoto I, Toyotama H, Brain JD, Gehr P. Magnetometric estimation of organelle motion in hamster lung macrophages in vitro: the effects of temperature. Front Med Biol Eng. 1989; 1(3):193-203.
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  95. Kobzik L, Godleski JJ, Barry BE, Brain JD. Isolation and antigenic identification of hamster lung interstitial macrophages. Am Rev Respir Dis. 1988 Oct; 138(4):908-14.
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  96. Weinstock SB, Brain JD. Comparison of particle clearance and macrophage phagosomal motion in liver and lungs of rats. J Appl Physiol. 1988 Oct; 65(4):1811-20.
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  97. Barry BE, Geyer RP, Brain JD. Pulmonary effects of blood replacement with a perfluorochemical emulsion followed by exposure to 85% oxygen or air. Am Rev Respir Dis. 1988 Aug; 138(2):435-44.
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  98. Warner AE, DeCamp MM, Molina RM, Brain JD. Pulmonary removal of circulating endotoxin results in acute lung injury in sheep. Lab Invest. 1988 Aug; 59(2):219-30.
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  99. Rose RM, Fuglestad JM, Skornik WA, Hammer SM, Wolfthal SF, Beck BD, Brain JD. The pathophysiology of enhanced susceptibility to murine cytomegalovirus respiratory infection during short-term exposure to 5 ppm nitrogen dioxide. Am Rev Respir Dis. 1988 Apr; 137(4):912-7.
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  100. Musk AW, Beck BD, Greville HW, Brain JD, Bohannon DE. Pulmonary disease from exposure to an artificial aluminium silicate: further observations. Br J Ind Med. 1988 Apr; 45(4):246-50.
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  101. Heyder J, Blanchard JD, Feldman HA, Brain JD. Convective mixing in human respiratory tract: estimates with aerosol boli. J Appl Physiol. 1988 Mar; 64(3):1273-8.
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  102. Brain JD. Lung macrophages: how many kinds are there? What do they do? Am Rev Respir Dis. 1988 Mar; 137(3):507-9.
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  103. Kriebel D, Brain JD, Sprince NL, Kazemi H. The pulmonary toxicity of beryllium. Am Rev Respir Dis. 1988 Feb; 137(2):464-73.
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  104. Valberg PA, Meyrick B, Brain JD, Brigham KL. Phagocytic and motile properties of endothelial cells measured magnetometrically: effects of endotoxin. Tissue Cell. 1988; 20(3):345-54.
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  105. Warner AE, Molina RM, Brain JD. Uptake of bloodborne bacteria by pulmonary intravascular macrophages and consequent inflammatory responses in sheep. Am Rev Respir Dis. 1987 Sep; 136(3):683-90.
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  106. Sweeney TD, Brain JD, Leavitt SA, Godleski JJ. Emphysema alters the deposition pattern of inhaled particles in hamsters. Am J Pathol. 1987 Jul; 128(1):19-28.
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  107. Feldman HA, Brain JD, Harbison ML. Adjusting for confounded variables: pulmonary function and smoking in a special population. Environ Res. 1987 Jun; 43(1):251-66.
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  108. Hallock MF, Smith TJ, Hammond SK, Beck BD, Brain JD. A new technique for collecting ambient diesel particles for bioassays. Am Ind Hyg Assoc J. 1987 May; 48(5):487-93.
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  109. Beck BD, Feldman HA, Brain JD, Smith TJ, Hallock M, Gerson B. The pulmonary toxicity of talc and granite dust as estimated from an in vivo hamster bioassay. Toxicol Appl Pharmacol. 1987 Feb; 87(2):222-34.
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  110. Stearns RC, Barnas GM, Walski M, Brain JD. Deposition and phagocytosis of inhaled particles in the gas exchange region of the duck, Anas platyrhynchos. Respir Physiol. 1987 Jan; 67(1):23-36.
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  111. Warner AE, Barry BE, Brain JD. Pulmonary intravascular macrophages in sheep. Morphology and function of a novel constituent of the mononuclear phagocyte system. Lab Invest. 1986 Sep; 55(3):276-88.
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  112. Warner AE, Brain JD. Intravascular pulmonary macrophages: a novel cell removes particles from blood. Am J Physiol. 1986 Apr; 250(4 Pt 2):R728-32.
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  113. Parod RJ, Brain JD. Immune opsonin-independent phagocytosis by pulmonary macrophages. J Immunol. 1986 Mar 15; 136(6):2041-7.
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  114. Parod RJ, Godleski JJ, Brain JD. Inhibition of immune opsonin-independent phagocytosis by antibody to a pulmonary macrophage cell surface antigen. J Immunol. 1986 Mar 15; 136(6):2048-54.
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  115. Brain JD. Toxicological aspects of alterations of pulmonary macrophage function. Annu Rev Pharmacol Toxicol. 1986; 26:547-65.
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  116. Kobzik L, Godleski JJ, Brain JD. Ultrastructural analysis of a specific hamster alveolar macrophage antigen. Lab Invest. 1985 Nov; 53(5):526-33.
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  117. Tryka AF, Sweeney TD, Brain JD, Godleski JJ. Short-term regional clearance of an inhaled submicrometric aerosol in pulmonary fibrosis. Am Rev Respir Dis. 1985 Sep; 132(3):606-11.
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  118. Godleski JJ, Mortara M, Joher MA, Kobzik L, Brain JD. Monoclonal antibody to an alveolar macrophage surface antigen in hamsters. Am Rev Respir Dis. 1984 Aug; 130(2):249-55.
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  119. Harbison ML, Godleski JJ, Mortara M, Brain JD. Correlation of lung macrophage age and surface antigen in the hamster. Lab Invest. 1984 Jun; 50(6):653-8.
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  120. Tryka AF, Godleski JJ, Brain JD. Differences in effects of immediate and delayed hyperoxia exposure on bleomycin-induced pulmonary injury. Cancer Treat Rep. 1984 May; 68(5):759-64.
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  121. Brain JD, Gehr P, Kavet RI. Airway macrophages. The importance of the fixation method. Am Rev Respir Dis. 1984 May; 129(5):823-6.
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  122. Godleski JJ, Joher MA, Goldstein JD, Brain JD. Chemical characterization of specific pulmonary macrophage cell surface antigen. Lung. 1984; 162(3):183-92.
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  123. Brain JD, Bloom SB, Valberg PA, Gehr P. Correlation between the behavior of magnetic iron oxide particles in the lungs of rabbits and phagocytosis. Exp Lung Res. 1984; 6(2):115-31.
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  124. Gehr P, Brain JD, Bloom SB. Noninvasive studies of Kupffer cells in situ by magnetometry. J Leukoc Biol. 1984 Jan; 35(1):19-30.
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  125. Godleski JJ, Brain JD. Natural and induced antisera specific for pulmonary macrophages. Lung. 1984; 162(3):171-82.
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  126. Tryka AF, Godleski JJ, Brain JD. Alterations in alveolar macrophages in hamsters developing pulmonary fibrosis. Exp Lung Res. 1984; 7(1):41-52.
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  127. Harbison ML, Brain JD. Effects of exercise on particle deposition in Syrian golden hamsters. Am Rev Respir Dis. 1983 Nov; 128(5):904-8.
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  128. Tryka AF, Godleski JJ, Skornik WA, Brain JD. Progressive pulmonary fibrosis in hamsters. Exp Lung Res. 1983 Nov; 5(3):155-71.
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  129. Gehr P, Brain JD, Nemoto I, Bloom SB. Behavior of magnetic particles in hamster lungs: estimates of clearance and cytoplasmic motility. J Appl Physiol. 1983 Oct; 55(4):1196-202.
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  130. Beck BD, Gerson B, Feldman HA, Brain JD. Lactate dehydrogenase isoenzymes in hamster lung lavage fluid after lung injury. Toxicol Appl Pharmacol. 1983 Oct; 71(1):59-71.
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  131. Parod RJ, Brain JD. Uptake of latex particles by macrophages: characterization using flow cytometry. Am J Physiol. 1983 Sep; 245(3):C220-6.
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  132. Parod RJ, Brain JD. Uptake of latex particles by pulmonary macrophages: role of calcium. Am J Physiol. 1983 Sep; 245(3):C227-34.
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  133. Skornik WA, Brain JD. Relative toxicity of inhaled metal sulfate salts for pulmonary macrophages. Am Rev Respir Dis. 1983 Aug; 128(2):297-303.
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  134. Brain JD, Mensah GA. Comparative toxicology of the respiratory tract. Am Rev Respir Dis. 1983 Aug; 128(2 Pt 2):S87-90.
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  135. Sweeney TD, Brain JD, Tryka AF, Godleski JJ. Retention of inhaled particles in hamsters with pulmonary fibrosis. Am Rev Respir Dis. 1983 Jul; 128(1):138-43.
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  136. Gehr P, Brain JD, Bloom SB, Valberg PA. Magnetic particles in the liver: a probe for intracellular movement. Nature. 1983 Mar 24-30; 302(5906):336-8.
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  137. Rose RM, Crumpacker C, Waner JL, Brain JD. Treatment of murine cytomegalovirus pneumonia with acyclovir and interferon. Am Rev Respir Dis. 1983 Feb; 127(2):198-203.
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  138. Sweeney TD, Brain JD, LeMott S. Anesthesia alters the pattern of aerosol retention in hamsters. J Appl Physiol. 1983 Jan; 54(1):37-44.
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  139. Tryka AF, Skornik WA, Godleski JJ, Brain JD. Potentiation of bleomycin-induced lung injury by exposure to 70% oxygen. Morphologic assessment. Am Rev Respir Dis. 1982 Dec; 126(6):1074-9.
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  140. Mensah GA, Brain JD. Deposition and clearance of inhaled aerosol in the respiratory tract of chickens. J Appl Physiol. 1982 Dec; 53(6):1423-8.
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  141. Valberg PA, Brain JD, Sneddon SL, LeMott SR. Breathing patterns influence aerosol deposition sites in excised dog lungs. J Appl Physiol. 1982 Oct; 53(4):824-37.
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  142. Beck BD, Brain JD, Bohannon DE. An in vivo hamster bioassay to assess the toxicity of particulates for the lungs. Toxicol Appl Pharmacol. 1982 Oct; 66(1):9-29.
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  143. Valberg PA, Chen BH, Brain JD. Endocytosis of colloidal gold by pulmonary macrophages. Exp Cell Res. 1982 Sep; 141(1):1-14.
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  144. Rose RM, Crumpacker C, Waner JL, Brain JD. Murine cytomegalovirus pneumonia. Description of a model and investigation of pathogenesis. Am Rev Respir Dis. 1982 May; 125(5):568-73.
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  145. Craig DK, Brain JD, Cuddihy RG, Kanapilly G, Phalen RF, Swift DL, Stuart BO. Implications of the dosimetric model for the respiratory system on limits for intakes of radionuclides by workers (ICRP Publication 30). Ann Occup Hyg. 1982; 26(1-4):163-76.
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  146. Smith TJ, Beck BD, Brain JD, Hinds WC, Baron SG, Weil L. Prediction of pneumoconiosis risk by bioassays of particulate from occupational exposures. Ann Occup Hyg. 1982; 26(1-4):435-48.
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  147. Sneddon SL, Brain JD. Steady expiratory flow in dog lungs: an isovolume preparation. J Appl Physiol. 1981 Nov; 51(5):1331-7.
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  148. Sneddon SL, Brain JD. Persistent apex to base gradients of aerosol deposition in rats. Respir Physiol. 1981 Nov; 46(2):113-24.
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  149. Beck BD, Brain JD, Bohannon DE. The pulmonary toxicity of an ash sample from the MT. St. Helens Volcano. Exp Lung Res. 1981 Nov; 2(4):289-301.
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  150. Grant MM, Brain JD, Vinegar A. Pulmonary defense mechanisms in Boa constrictor. J Appl Physiol. 1981 May; 50(5):979-83.
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  151. Valberg PA, Brain JD, Kane D. Effects of colchicine or cytochalasin B on pulmonary macrophage endocytosis in vivo. J Appl Physiol. 1981 Mar; 50(3):621-9.
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  152. Brain J. Aerosol and humidity therapy. Am Rev Respir Dis. 1980 Nov; 122(5 Pt 2):17-21.
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  153. Brain JD. Macrophage damage in relation to the pathogenesis of lung diseases. Environ Health Perspect. 1980 Apr; 35:21-8.
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  154. Watson AY, Brain JD. The effect of SO2 on the uptake of particles by mouse bronchial epithelium. Exp Lung Res. 1980 Mar; 1(1):67-87.
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  155. Kavet RI, Brain JD. Methods to quantify endocytosis: a review. J Reticuloendothel Soc. 1980 Feb; 27(2):201-21.
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  156. Brain JD. Pulmonary macrophages: when do they prevent and when do they cause COPD? Chest. 1980 Feb; 77(2 Suppl):264-5.
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  157. Brain JD, Valberg PA. Deposition of aerosol in the respiratory tract. Am Rev Respir Dis. 1979 Dec; 120(6):1325-73.
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  158. Grant MM, Sorokin SP, Brain JD. Lysosomal enzyme activities in pulmonary macrophages from rabbits breathing iron oxide. Am Rev Respir Dis. 1979 Nov; 120(5):1003-12.
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  159. Valberg PA, Brain JD. Generation and use of three types of iron-oxide aerosol. Am Rev Respir Dis. 1979 Nov; 120(5):1013-24.
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  160. Frank R, Brain JD, Knudson DE, Kronmal RA. Ozone exposure, adaptation, and changes in lung elasticity. Environ Res. 1979 Aug; 19(2):449-59.
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  161. Watson AY, Brain JD. Uptake of iron aerosols by mouse airway epithelium. Lab Invest. 1979 Apr; 40(4):450-9.
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  162. Brain JD, Golde DW, Green GM, Massaro DJ, Valberg PA, Ward PA, Werb Z. Biologic potential of pulmonary macrophages. Am Rev Respir Dis. 1978 Aug; 118(2):435-43.
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  163. Kavet RI, Brain JD, Levens DJ. Characteristics of pulmonary macrophages lavaged from hamsters exposed to iron oxide aerosols. Lab Invest. 1978 Mar; 38(3):312-9.
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  164. Brain JD. The respiratory tract and the environment. Environ Health Perspect. 1977 Oct; 20:113-26.
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  165. Valberg PA, Brain JD. Lung surface tension and air space dimensions from multiple pressure-volume curves. J Appl Physiol. 1977 Oct; 43(4):730-8.
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  166. Kavet RI, Brain JD. Phagocytosis: quantification of rates and intercellular heterogeneity. J Appl Physiol. 1977 Mar; 42(3):432-7.
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  167. Brain JD. Anesthesia and respiratory defense mechanisms. Int Anesthesiol Clin. 1977; 15(2):169-98.
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  168. Brain JD, Knudson DE, Sorokin SP, Davis MA. Pulmonary distribution of particles given by intratracheal instillation or by aerosol inhalation. Environ Res. 1976 Feb; 11(1):13-33.
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  169. McMahon TA, Brain JD, Lemott S. Species differences in aerosol deposition. Inhaled Part. 1975 Sep; 4 Pt 1:23-33.
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  170. Brain JD, Corkery GC. The effect of increased particles on the endocytosis of radiocolloids by pulmonary macrophages in vivo: competitive and toxic effects. Inhaled Part. 1975 Sep; 4 Pt 2:551-64.
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  171. Sorokin SP, Brain JD. Pathways of clearance in mouse lungs exposed to iron oxide aerosols. Anat Rec. 1975 Mar; 181(3):581-625.
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  172. Kavet RI, Brain JD. Reaction of the lung to air pollutant exposure. Life Sci. 1974 Sep 1; 15(5):849-61.
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  173. Brain JD, Valberg PA. Models of lung retention based on ICRP task group report. Arch Environ Health. 1974 Jan; 28(1):1-11.
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  174. Frank R, Brain JD, Yokoyams E. Compression atelectasis: a method for unilateral ventilation of the lung. J Appl Physiol. 1973 May; 34(5):704-7.
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  175. Brain JD, Frank R. Alveolar macrophage adhesion: wash electrolyte composition and free cell yield. J Appl Physiol. 1973 Jan; 34(1):75-80.
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  176. Godleski JJ, Brain JD. The origin of alveolar macrophages in mouse radiation chimeras. J Exp Med. 1972 Sep 1; 136(3):630-43.
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  177. Frank R, Flesch JP, Brain JD. Effect of ozone on elastic behavior of excised lungs of dogs. Environ Res. 1971 Oct; 4(4):343-54.
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  178. Brain JD. Free cells in the lungs. Some aspects of their role, quantitation, and regulation. Arch Intern Med. 1970 Sep; 126(3):477-87.
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  179. Brain JD. The effects of increased particles on the number of alveolar macrophages. Inhaled Part. 1970; 1:209-25.
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  180. Bouhuys A, Wolfson RL, Horner DW, Brain JD, Zuskin E. Byssinosis in cotton textile workers. Respiratory survey of a mill with rapid labor turnover. Ann Intern Med. 1969 Aug; 71(2):257-69.
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  181. Woolcock AJ, Macklem PT, Hogg JC, Wilson NJ, Nadel JA, Frank NR, Brain J. Effect of vagal stimulation on central and peripheral airways in dogs. J Appl Physiol. 1969 Jun; 26(6):806-13.
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  182. Frank NR, Yoder RE, Brain JD, Yokoyama E. SO2 (35S labeled) absorption by the nose and mouth under conditions of varying concentration and flow. Arch Environ Health. 1969 Mar; 18(3):315-22.
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  183. Brain JD, Frank NR. Recovery of free cells from rat lungs by repeated washings. J Appl Physiol. 1968 Jul; 25(1):63-9.
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  184. Brain JD, Frank NR. The relation of age to the numbers of lung free cells, lung weight, and body weight in rats. J Gerontol. 1968 Jan; 23(1):58-62.
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