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Gregory Paul Priebe, M.D.

TitleAssociate Professor of Anaesthesia
InstitutionChildren's Hospital Boston
DepartmentAnaesthesia
AddressChildrens Hospital
Div. of Critical Care Medicine/Anesthesia, Bader 6
300 Longwood Ave
Boston MA 02115
Phone617/525-2663
Fax617/525-2663

 Mentoring 
 current student opportunities
Available: 09/01/13, Expires: 09/01/14

My lab studies immunity to bacterial infections, particularly Pseudomonas aeruginosa and bacteria in the Burkholderia cepacia complex, with the ultimate goal of developing new treatments and vaccines. We use murine models of infection and also do translational research using bacterial samples and immune cells/serum from humans. A number of potential projects embedded within larger projects are available.

Available: 11/01/12, Expires: 09/30/14

My lab studies immunity to bacterial infections, particularly Pseudomonas aeruginosa and bacteria in the Burkholderia cepacia complex, with the ultimate goal of developing new treatments and vaccines. We use murine models of infection and also do translational research using bacterial samples and immune cells/serum from humans. A number of potential projects embedded within larger projects are available.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lieberman TD, Flett KB, Yelin I, Martin TR, McAdam AJ, Priebe GP, Kishony R. Genetic variation of a bacterial pathogen within individuals with cystic fibrosis provides a record of selective pressures. Nat Genet. 2014 Jan; 46(1):82-7.
    View in: PubMed
  2. Djonovic S, Urbach JM, Drenkard E, Bush J, Feinbaum R, Ausubel JL, Traficante D, Risech M, Kocks C, Fischbach MA, Priebe GP, Ausubel FM. Trehalose Biosynthesis Promotes Pseudomonas aeruginosa Pathogenicity in Plants. PLoS Pathog. 2013 Mar; 9(3):e1003217.
    View in: PubMed
  3. Hong H, Morrow DF, Sandora TJ, Priebe GP. Disinfection of needleless connectors with chlorhexidine-alcohol provides long-lasting residual disinfectant activity. Am J Infect Control. 2013 Aug; 41(8):e77-9.
    View in: PubMed
  4. Kamei A, Wu W, Traficante DC, Koh AY, Van Rooijen N, Pier GB, Priebe GP. Collaboration Between Macrophages and Vaccine-Induced CD4+ T Cells Confers Protection Against Lethal Pseudomonas aeruginosa Pneumonia During Neutropenia. J Infect Dis. 2013 Jan; 207(1):39-49.
    View in: PubMed
  5. Tamang DL, Pirzai W, Priebe GP, Traficante DC, Pier GB, Falck JR, Morisseau C, Hammock BD, McCormick BA, Gronert K, Hurley BP. Hepoxilin a3 facilitates neutrophilic breach of lipoxygenase-expressing airway epithelial barriers. J Immunol. 2012 Nov 15; 189(10):4960-9.
    View in: PubMed
  6. Zaidi TS, Zaidi T, Pier GB, Priebe GP. Topical neutralization of interleukin-17 during experimental Pseudomonas aeruginosa corneal infection promotes bacterial clearance and reduces pathology. Infect Immun. 2012 Oct; 80(10):3706-12.
    View in: PubMed
  7. Wu W, Huang J, Duan B, Traficante DC, Hong H, Risech M, Lory S, Priebe GP. Th17-stimulating protein vaccines confer protection against Pseudomonas aeruginosa pneumonia. Am J Respir Crit Care Med. 2012 Sep 1; 186(5):420-7.
    View in: PubMed
  8. Skurnik D, Davis MR, Benedetti D, Moravec KL, Cywes-Bentley C, Roux D, Traficante DC, Walsh RL, Maira-Litràn T, Cassidy SK, Hermos CR, Martin TR, Thakkallapalli EL, Vargas SO, McAdam AJ, Lieberman TD, Kishony R, Lipuma JJ, Pier GB, Goldberg JB, Priebe GP. Targeting pan-resistant bacteria with antibodies to a broadly conserved surface polysaccharide expressed during infection. J Infect Dis. 2012 Jun; 205(11):1709-18.
    View in: PubMed
  9. Lieberman TD, Michel JB, Aingaran M, Potter-Bynoe G, Roux D, Davis MR, Skurnik D, Leiby N, LiPuma JJ, Goldberg JB, McAdam AJ, Priebe GP, Kishony R. Parallel bacterial evolution within multiple patients identifies candidate pathogenicity genes. Nat Genet. 2011 Dec; 43(12):1275-80.
    View in: PubMed
  10. Kamei A, Coutinho-Sledge YS, Goldberg JB, Priebe GP, Pier GB. Mucosal vaccination with a multivalent, live-attenuated vaccine induces multifactorial immunity against Pseudomonas aeruginosa acute lung infection. Infect Immun. 2011 Mar; 79(3):1289-99.
    View in: PubMed
  11. Kamei A, Koh AY, Gadjeva M, Priebe GP, Lory S, Pier GB. Analysis of acquisition of Pseudomonas aeruginosa gastrointestinal mucosal colonization and horizontal transmission in a murine model. J Infect Dis. 2010 Jan 1; 201(1):71-80.
    View in: PubMed
  12. Gadjeva M, Paradis-Bleau C, Priebe GP, Fichorova R, Pier GB. Caveolin-1 modifies the immunity to Pseudomonas aeruginosa. J Immunol. 2010 Jan 1; 184(1):296-302.
    View in: PubMed
  13. Koh AY, Priebe GP, Ray C, Van Rooijen N, Pier GB. Inescapable need for neutrophils as mediators of cellular innate immunity to acute Pseudomonas aeruginosa pneumonia. Infect Immun. 2009 Dec; 77(12):5300-10.
    View in: PubMed
  14. Priebe GP, Walsh RL, Cederroth TA, Kamei A, Coutinho-Sledge YS, Goldberg JB, Pier GB. IL-17 is a critical component of vaccine-induced protection against lung infection by lipopolysaccharide-heterologous strains of Pseudomonas aeruginosa. J Immunol. 2008 Oct 1; 181(7):4965-75.
    View in: PubMed
  15. Benarafa C, Priebe GP, Remold-O'Donnell E. The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection. J Exp Med. 2007 Aug 6; 204(8):1901-9.
    View in: PubMed
  16. Zaidi TS, Priebe GP, Pier GB. A live-attenuated Pseudomonas aeruginosa vaccine elicits outer membrane protein-specific active and passive protection against corneal infection. Infect Immun. 2006 Feb; 74(2):975-83.
    View in: PubMed
  17. Priebe GP. Sepsis in the immunocompromised child: the least studied with the most to gain. Pediatr Crit Care Med. 2005 May; 6(3 Suppl):S78-9.
    View in: PubMed
  18. Koh AY, Priebe GP, Pier GB. Virulence of Pseudomonas aeruginosa in a murine model of gastrointestinal colonization and dissemination in neutropenia. Infect Immun. 2005 Apr; 73(4):2262-72.
    View in: PubMed
  19. Pier GB, Boyer D, Preston M, Coleman FT, Llosa N, Mueschenborn-Koglin S, Theilacker C, Goldenberg H, Uchin J, Priebe GP, Grout M, Posner M, Cavacini L. Human monoclonal antibodies to Pseudomonas aeruginosa alginate that protect against infection by both mucoid and nonmucoid strains. J Immunol. 2004 Nov 1; 173(9):5671-8.
    View in: PubMed
  20. Priebe GP, Dean CR, Zaidi T, Meluleni GJ, Coleman FT, Coutinho YS, Noto MJ, Urban TA, Pier GB, Goldberg JB. The galU Gene of Pseudomonas aeruginosa is required for corneal infection and efficient systemic spread following pneumonia but not for infection confined to the lung. Infect Immun. 2004 Jul; 72(7):4224-32.
    View in: PubMed
  21. Priebe GP, Meluleni GJ, Coleman FT, Goldberg JB, Pier GB. Protection against fatal Pseudomonas aeruginosa pneumonia in mice after nasal immunization with a live, attenuated aroA deletion mutant. Infect Immun. 2003 Mar; 71(3):1453-61.
    View in: PubMed
  22. Priebe GP, Pier GB. Vaccines for Pseudomonas aeruginosa. In: Ellis RW, Brodeur BR, editors. New bacterial vaccines. 2003; 261-283.
  23. Priebe GP, Brinig MM, Hatano K, Grout M, Coleman FT, Pier GB, Goldberg JB. Construction and characterization of a live, attenuated aroA deletion mutant of Pseudomonas aeruginosa as a candidate intranasal vaccine. Infect Immun. 2002 Mar; 70(3):1507-17.
    View in: PubMed
  24. Priebe GP, Arnold JH. High-frequency oscillatory ventilation in pediatric patients. Respir Care Clin N Am. 2001 Dec; 7(4):633-45.
    View in: PubMed
  25. Heininger A, Ulrich M, Priebe G, Unertl K, Müller-Schauenburg A, Botzenhart K, Döring G. The effect of human serum DNAases on the ability to detect antibiotic-killed Escherichia coli in blood by PCR. J Med Microbiol. 2001 Mar; 50(3):243-8.
    View in: PubMed
  26. Priebe GP, Arnold JH. High frequency oscillatory ventilation in pediatric patients. In: Stewart T, editor. Respiratory Care Clinics of North America. 2001; 7(4):633-645.
  27. Allewelt M, Coleman FT, Grout M, Priebe GP, Pier GB. Acquisition of expression of the Pseudomonas aeruginosa ExoU cytotoxin leads to increased bacterial virulence in a murine model of acute pneumonia and systemic spread. Infect Immun. 2000 Jul; 68(7):3998-4004.
    View in: PubMed
  28. Harris EW, D'Amico DJ, Bhisitkul R, Priebe GP, Petersen R. Bacterial subretinal abscess: a case report and review of the literature. Am J Ophthalmol. 2000 Jun; 129(6):778-85.
    View in: PubMed
  29. Headrick LA, Richardson A, Priebe GP. Continuous improvement learning for residents. Pediatrics. 1998 Apr; 101(4 Pt 2):768-73; discussion 773-4.
    View in: PubMed
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