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Last Name
Institution

Jing Zhou, PH.D., M.D.

TitleAssociate Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressHarvard Institutes of Medicine
Room 522
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/525-5861
Fax617/525-5861

 Mentoring 
 current student opportunities
Available: 11/01/11, Expires: 11/30/15

We use multidisciplinary approaches to understand the molecular mechanisms underlying human polycystic kidney diseases (PKD) and to develop therapeutic strategies. The dominant form of the disease alone is the most common monogenetic disorder in humans. A student can become a valuable member of the team and contribute to our research progress and co-author in research publications.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Takakura A, Nelson EA, Haque N, Humphreys BD, Zandi-Nejad K, Frank DA, Zhou J. Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways. Hum Mol Genet. 2011 Nov 1; 20(21):4143-54.
    View in: PubMed
  2. Pandey P, Qin S, Ho J, Zhou J, Kreidberg JA. Systems biology approach to identify transcriptome reprogramming and candidate microRNA targets during the progression of polycystic kidney disease. BMC Syst Biol. 2011; 5:56.
    View in: PubMed
  3. Yu W, Ritchie BJ, Su X, Zhou J, Meigs TE, Denker BM. Identification of polycystin-1 and Ga12 binding regions necessary for regulation of apoptosis. Cell Signal. 2011 Jan; 23(1):213-21.
    View in: PubMed
  4. Qin S, Taglienti M, Nauli SM, Contrino L, Takakura A, Zhou J, Kreidberg JA. Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease. J Clin Invest. 2010 Oct; 120(10):3617-28.
    View in: PubMed
  5. Subramanian B, Rudym D, Cannizzaro C, Perrone R, Zhou J, Kaplan DL. Tissue-engineered three-dimensional in vitro models for normal and diseased kidney. Tissue Eng Part A. 2010 Sep; 16(9):2821-31.
    View in: PubMed
  6. Luyten A, Su X, Gondela S, Chen Y, Rompani S, Takakura A, Zhou J. Aberrant regulation of planar cell polarity in polycystic kidney disease. J Am Soc Nephrol. 2010 Sep; 21(9):1521-32.
    View in: PubMed
  7. Zhang J, Wu M, Wang S, Shah JV, Wilson PD, Zhou J. Polycystic kidney disease protein fibrocystin localizes to the mitotic spindle and regulates spindle bipolarity. Hum Mol Genet. 2010 Sep 1; 19(17):3306-19.
    View in: PubMed
  8. Besschetnova TY, Kolpakova-Hart E, Guan Y, Zhou J, Olsen BR, Shah JV. Identification of signaling pathways regulating primary cilium length and flow-mediated adaptation. Curr Biol. 2010 Jan 26; 20(2):182-7.
    View in: PubMed
  9. Zhou X, Bao H, Takakura A, Zhou J, Albert M, Sun Y. Polycystic kidney disease evaluation by magnetic resonance imaging in ischemia-reperfusion injured PKD1 knockout mouse model: comparison of T2-weighted FSE and true-FISP. Invest Radiol. 2010 Jan; 45(1):24-8.
    View in: PubMed
  10. Takakura A, Contrino L, Zhou X, Bonventre JV, Sun Y, Humphreys BD, Zhou J. Renal injury is a third hit promoting rapid development of adult polycystic kidney disease. Hum Mol Genet. 2009 Jul 15; 18(14):2523-31.
    View in: PubMed
  11. Zhang P, Luo Y, Chasan B, González-Perrett S, Montalbetti N, Timpanaro GA, Cantero Mdel R, Ramos AJ, Goldmann WH, Zhou J, Cantiello HF. The multimeric structure of polycystin-2 (TRPP2): structural-functional correlates of homo- and hetero-multimers with TRPC1. Hum Mol Genet. 2009 Apr 1; 18(7):1238-51.
    View in: PubMed
  12. Zhou J. Polycystins and primary cilia: primers for cell cycle progression. Annu Rev Physiol. 2009; 71:83-113.
    View in: PubMed
  13. Alcalay NI, Sharma M, Vassmer D, Chapman B, Paul B, Zhou J, Brantley JG, Wallace DP, Maser RL, Vanden Heuvel GB. Acceleration of polycystic kidney disease progression in cpk mice carrying a deletion in the homeodomain protein Cux1. Am J Physiol Renal Physiol. 2008 Dec; 295(6):F1725-34.
    View in: PubMed
  14. Takakura A, Contrino L, Beck AW, Zhou J. Pkd1 inactivation induced in adulthood produces focal cystic disease. J Am Soc Nephrol. 2008 Dec; 19(12):2351-63.
    View in: PubMed
  15. Kolpakova-Hart E, McBratney-Owen B, Hou B, Fukai N, Nicolae C, Zhou J, Olsen BR. Growth of cranial synchondroses and sutures requires polycystin-1. Dev Biol. 2008 Sep 15; 321(2):407-19.
    View in: PubMed
  16. Kolpakova-Hart E, Nicolae C, Zhou J, Olsen BR. Col2-Cre recombinase is co-expressed with endogenous type II collagen in embryonic renal epithelium and drives development of polycystic kidney disease following inactivation of ciliary genes. Matrix Biol. 2008 Jul; 27(6):505-12.
    View in: PubMed
  17. Starremans PG, Li X, Finnerty PE, Guo L, Takakura A, Neilson EG, Zhou J. A mouse model for polycystic kidney disease through a somatic in-frame deletion in the 5' end of Pkd1. Kidney Int. 2008 Jun; 73(12):1394-405.
    View in: PubMed
  18. Dedoussis GV, Luo Y, Starremans P, Rossetti S, Ramos AJ, Cantiello HF, Katsareli E, Ziroyannis P, Lamnissou K, Harris PC, Zhou J. Co-inheritance of a PKD1 mutation and homozygous PKD2 variant: a potential modifier in autosomal dominant polycystic kidney disease. Eur J Clin Invest. 2008 Mar; 38(3):180-90.
    View in: PubMed
  19. Nauli SM, Kawanabe Y, Kaminski JJ, Pearce WJ, Ingber DE, Zhou J. Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1. Circulation. 2008 Mar 4; 117(9):1161-71.
    View in: PubMed
  20. Sohara E, Luo Y, Zhang J, Manning DK, Beier DR, Zhou J. Nek8 regulates the expression and localization of polycystin-1 and polycystin-2. J Am Soc Nephrol. 2008 Mar; 19(3):469-76.
    View in: PubMed
  21. Mrug M, Zhou J, Woo Y, Cui X, Szalai AJ, Novak J, Churchill GA, Guay-Woodford LM. Overexpression of innate immune response genes in a model of recessive polycystic kidney disease. Kidney Int. 2008 Jan; 73(1):63-76.
    View in: PubMed
  22. Tian Y, Kolb R, Hong JH, Carroll J, Li D, You J, Bronson R, Yaffe MB, Zhou J, Benjamin T. TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex. Mol Cell Biol. 2007 Sep; 27(18):6383-95.
    View in: PubMed
  23. Wang S, Zhang J, Nauli SM, Li X, Starremans PG, Luo Y, Roberts KA, Zhou J. Fibrocystin/polyductin, found in the same protein complex with polycystin-2, regulates calcium responses in kidney epithelia. Mol Cell Biol. 2007 Apr; 27(8):3241-52.
    View in: PubMed
  24. Stayner C, Iglesias DM, Goodyer PR, Ellis L, Germino G, Zhou J, Eccles MR. Pax2 gene dosage influences cystogenesis in autosomal dominant polycystic kidney disease. Hum Mol Genet. 2006 Dec 15; 15(24):3520-8.
    View in: PubMed
  25. Gunay-Aygun M, Avner ED, Bacallao RL, Choyke PL, Flynn JT, Germino GG, Guay-Woodford L, Harris P, Heller T, Ingelfinger J, Kaskel F, Kleta R, LaRusso NF, Mohan P, Pazour GJ, Shneider BL, Torres VE, Wilson P, Zak C, Zhou J, Gahl WA. Autosomal recessive polycystic kidney disease and congenital hepatic fibrosis: summary statement of a first National Institutes of Health/Office of Rare Diseases conference. J Pediatr. 2006 Aug; 149(2):159-64.
    View in: PubMed
  26. Wilson SJ, Amsler K, Hyink DP, Li X, Lu W, Zhou J, Burrow CR, Wilson PD. Inhibition of HER-2(neu/ErbB2) restores normal function and structure to polycystic kidney disease (PKD) epithelia. Biochim Biophys Acta. 2006 Jul; 1762(7):647-55.
    View in: PubMed
  27. Bui-Xuan EF, Li Q, Chen XZ, Boucher CA, Sandford R, Zhou J, Basora N. More than colocalizing with polycystin-1, polycystin-L is in the centrosome. Am J Physiol Renal Physiol. 2006 Aug; 291(2):F395-406.
    View in: PubMed
  28. Nauli SM, Rossetti S, Kolb RJ, Alenghat FJ, Consugar MB, Harris PC, Ingber DE, Loghman-Adham M, Zhou J. Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction. J Am Soc Nephrol. 2006 Apr; 17(4):1015-25.
    View in: PubMed
  29. Li X, Luo Y, Starremans PG, McNamara CA, Pei Y, Zhou J. Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2. Nat Cell Biol. 2005 Dec; 7(12):1202-12.
    View in: PubMed
  30. Hughes P, Robati M, Lu W, Zhou J, Strasser A, Bouillet P. Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms. Cell Death Differ. 2006 Jul; 13(7):1123-7.
    View in: PubMed
  31. Sharma M, Brantley JG, Alcalay NI, Zhou J, Heystek E, Maser RL, Vanden Heuvel GB. Differential expression of Cux-1 and p21 in polycystic kidneys from Pkd1 null and cpk mice. Kidney Int. 2005 Feb; 67(2):432-42.
    View in: PubMed
  32. Alenghat FJ, Nauli SM, Kolb R, Zhou J, Ingber DE. Global cytoskeletal control of mechanotransduction in kidney epithelial cells. Exp Cell Res. 2004 Nov 15; 301(1):23-30.
    View in: PubMed
  33. Nauli SM, Zhou J. Polycystins and mechanosensation in renal and nodal cilia. Bioessays. 2004 Aug; 26(8):844-56.
    View in: PubMed
  34. Yuasa T, Takakura A, Denker BM, Venugopal B, Zhou J. Polycystin-1L2 is a novel G-protein-binding protein. Genomics. 2004 Jul; 84(1):126-38.
    View in: PubMed
  35. Wang S, Luo Y, Wilson PD, Witman GB, Zhou J. The autosomal recessive polycystic kidney disease protein is localized to primary cilia, with concentration in the basal body area. J Am Soc Nephrol. 2004 Mar; 15(3):592-602.
    View in: PubMed
  36. Delmas P, Nauli SM, Li X, Coste B, Osorio N, Crest M, Brown DA, Zhou J. Gating of the polycystin ion channel signaling complex in neurons and kidney cells. FASEB J. 2004 Apr; 18(6):740-2.
    View in: PubMed
  37. Thielen BK, Barker DF, Nelson RD, Zhou J, Kren SM, Segal Y. Deletion mapping in Alport syndrome and Alport syndrome-diffuse leiomyomatosis reveals potential mechanisms of visceral smooth muscle overgrowth. Hum Mutat. 2003 Nov; 22(5):419.
    View in: PubMed
  38. Loghman-Adham M, Nauli SM, Soto CE, Kariuki B, Zhou J. Immortalized epithelial cells from human autosomal dominant polycystic kidney cysts. Am J Physiol Renal Physiol. 2003 Sep; 285(3):F397-412.
    View in: PubMed
  39. Luo Y, Vassilev PM, Li X, Kawanabe Y, Zhou J. Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia. Mol Cell Biol. 2003 Apr; 23(7):2600-7.
    View in: PubMed
  40. Nauli SM, Alenghat FJ, Luo Y, Williams E, Vassilev P, Li X, Elia AE, Lu W, Brown EM, Quinn SJ, Ingber DE, Zhou J. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet. 2003 Feb; 33(2):129-37.
    View in: PubMed
  41. Lakkis M, Zhou J. Molecular complexes formed with polycystins. Nephron Exp Nephrol. 2003 Jan; 93(1):e3-8.
    View in: PubMed
  42. Sun Y, Zhou J, Stayner C, Munasinghe J, Shen X, Beier DR, Albert MS. Magnetic resonance imaging assessment of a murine model of recessive polycystic kidney disease. Comp Med. 2002 Oct; 52(5):433-8.
    View in: PubMed
  43. Liu Y, Li Q, Tan M, Zhang YY, Karpinski E, Zhou J, Chen XZ. Modulation of the human polycystin-L channel by voltage and divalent cations. FEBS Lett. 2002 Aug 14; 525(1-3):71-6.
    View in: PubMed
  44. Yuasa T, Venugopal B, Weremowicz S, Morton CC, Guo L, Zhou J. The sequence, expression, and chromosomal localization of a novel polycystic kidney disease 1-like gene, PKD1L1, in human. Genomics. 2002 Mar; 79(3):376-86.
    View in: PubMed
  45. Basora N, Nomura H, Berger UV, Stayner C, Guo L, Shen X, Zhou J. Tissue and cellular localization of a novel polycystic kidney disease-like gene product, polycystin-L. J Am Soc Nephrol. 2002 Feb; 13(2):293-301.
    View in: PubMed
  46. Delmas P, Nomura H, Li X, Lakkis M, Luo Y, Segal Y, Fernández-Fernández JM, Harris P, Frischauf AM, Brown DA, Zhou J. Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2. J Biol Chem. 2002 Mar 29; 277(13):11276-83.
    View in: PubMed
  47. Stayner C, Zhou J. Polycystin channels and kidney disease. Trends Pharmacol Sci. 2001 Nov; 22(11):543-6.
    View in: PubMed
  48. Lu W, Shen X, Pavlova A, Lakkis M, Ward CJ, Pritchard L, Harris PC, Genest DR, Perez-Atayde AR, Zhou J. Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects. Hum Mol Genet. 2001 Oct 1; 10(21):2385-96.
    View in: PubMed
  49. Chen XZ, Segal Y, Basora N, Guo L, Peng JB, Babakhanlou H, Vassilev PM, Brown EM, Hediger MA, Zhou J. Transport function of the naturally occurring pathogenic polycystin-2 mutant, R742X. Biochem Biophys Res Commun. 2001 Apr 20; 282(5):1251-6.
    View in: PubMed
  50. Vassilev PM, Guo L, Chen XZ, Segal Y, Peng JB, Basora N, Babakhanlou H, Cruger G, Kanazirska M. Polycystin-2 is a novel cation channel implicated in defective intracellular Ca(2+) homeostasis in polycystic kidney disease. Biochem Biophys Res Commun. 2001 Mar 23; 282(1):341-50.
    View in: PubMed
  51. Segal Y, Zhuang L, Rondeau E, Sraer JD, Zhou J. Regulation of the paired type IV collagen genes COL4A5 and COL4A6. Role of the proximal promoter region. J Biol Chem. 2001 Apr 13; 276(15):11791-7.
    View in: PubMed
  52. Pritchard L, Sloane-Stanley JA, Sharpe JA, Aspinwall R, Lu W, Buckle V, Strmecki L, Walker D, Ward CJ, Alpers CE, Zhou J, Wood WG, Harris PC. A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype. Hum Mol Genet. 2000 Nov 1; 9(18):2617-27.
    View in: PubMed
  53. Guo L, Schreiber TH, Weremowicz S, Morton CC, Lee C, Zhou J. Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization. Genomics. 2000 Mar 15; 64(3):241-51.
    View in: PubMed
  54. Guo L, Chen M, Basora N, Zhou J. The human polycystic kidney disease 2-like (PKDL) gene: exon/intron structure and evidence for a novel splicing mechanism. Mamm Genome. 2000 Jan; 11(1):46-50.
    View in: PubMed
  55. Chen XZ, Vassilev PM, Basora N, Peng JB, Nomura H, Segal Y, Brown EM, Reeders ST, Hediger MA, Zhou J. Polycystin-L is a calcium-regulated cation channel permeable to calcium ions. Nature. 1999 Sep 23; 401(6751):383-6.
    View in: PubMed
  56. Lu W, Fan X, Basora N, Babakhanlou H, Law T, Rifai N, Harris PC, Perez-Atayde AR, Rennke HG, Zhou J. Late onset of renal and hepatic cysts in Pkd1-targeted heterozygotes. Nat Genet. 1999 Feb; 21(2):160-1.
    View in: PubMed
  57. Segal Y, Peissel B, Renieri A, de Marchi M, Ballabio A, Pei Y, Zhou J. LINE-1 elements at the sites of molecular rearrangements in Alport syndrome-diffuse leiomyomatosis. Am J Hum Genet. 1999 Jan; 64(1):62-9.
    View in: PubMed
  58. Piccini M, Casari G, Zhou J, Bruttini M, Volti SL, Ballabio A, Renieri A. Evidence for genetic heterogeneity in benign familial hematuria. Am J Nephrol. 1999; 19(4):464-7.
    View in: PubMed
  59. Martin P, Heiskari N, Zhou J, Leinonen A, Tumelius T, Hertz JM, Barker D, Gregory M, Atkin C, Styrkarsdottir U, Neumann H, Springate J, Shows T, Pettersson E, Tryggvason K. High mutation detection rate in the COL4A5 collagen gene in suspected Alport syndrome using PCR and direct DNA sequencing. J Am Soc Nephrol. 1998 Dec; 9(12):2291-301.
    View in: PubMed
  60. Nomura H, Turco AE, Pei Y, Kalaydjieva L, Schiavello T, Weremowicz S, Ji W, Morton CC, Meisler M, Reeders ST, Zhou J. Identification of PKDL, a novel polycystic kidney disease 2-like gene whose murine homologue is deleted in mice with kidney and retinal defects. J Biol Chem. 1998 Oct 2; 273(40):25967-73.
    View in: PubMed
  61. Sasaki S, Zhou B, Fan WW, Kim Y, Barker DF, Denison JC, Atkin CL, Gregory MC, Zhou J, Segal Y, Sado Y, Ninomiya Y, Michael AF, Kashtan CE. Expression of mRNA for type IV collagen alpha1, alpha5 and alpha6 chains by cultured dermal fibroblasts from patients with X-linked Alport syndrome. Matrix Biol. 1998 Aug; 17(4):279-91.
    View in: PubMed
  62. Lu W, Peissel B, Babakhanlou H, Pavlova A, Geng L, Fan X, Larson C, Brent G, Zhou J. Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation. Nat Genet. 1997 Oct; 17(2):179-81.
    View in: PubMed
  63. Kahsai TZ, Enders GC, Gunwar S, Brunmark C, Wieslander J, Kalluri R, Zhou J, Noelken ME, Hudson BG. Seminiferous tubule basement membrane. Composition and organization of type IV collagen chains, and the linkage of alpha3(IV) and alpha5(IV) chains. J Biol Chem. 1997 Jul 4; 272(27):17023-32.
    View in: PubMed
  64. Geng L, Segal Y, Pavlova A, Barros EJ, Löhning C, Lu W, Nigam SK, Frischauf AM, Reeders ST, Zhou J. Distribution and developmentally regulated expression of murine polycystin. Am J Physiol. 1997 Apr; 272(4 Pt 2):F451-9.
    View in: PubMed
  65. Heidet L, Cohen-Solal L, Boye E, Thorner P, Kemper MJ, David A, Larget Piet L, Zhou J, Flinter F, Zhang X, Gubler MC, Antignac C. Novel COL4A5/COL4A6 deletions and further characterization of the diffuse leiomyomatosis-Alport syndrome (DL-AS) locus define the DL critical region. Cytogenet Cell Genet. 1997; 78(3-4):240-6.
    View in: PubMed
  66. Geng L, Segal Y, Peissel B, Deng N, Pei Y, Carone F, Rennke HG, Glücksmann-Kuis AM, Schneider MC, Ericsson M, Reeders ST, Zhou J. Identification and localization of polycystin, the PKD1 gene product. J Clin Invest. 1996 Dec 15; 98(12):2674-82.
    View in: PubMed
  67. Schneider MC, Rodriguez AM, Nomura H, Zhou J, Morton CC, Reeders ST, Weremowicz S. A gene similar to PKD1 maps to chromosome 4q22: a candidate gene for PKD2. Genomics. 1996 Nov 15; 38(1):1-4.
    View in: PubMed
  68. Renieri A, Bruttini M, Galli L, Zanelli P, Neri T, Rossetti S, Turco A, Heiskari N, Zhou J, Gusmano R, Massella L, Banfi G, Scolari F, Sessa A, Rizzoni G, Tryggvason K, Pignatti PF, Savi M, Ballabio A, De Marchi M. X-linked Alport syndrome: an SSCP-based mutation survey over all 51 exons of the COL4A5 gene. Am J Hum Genet. 1996 Jun; 58(6):1192-204.
    View in: PubMed
  69. Heiskari N, Zhang X, Zhou J, Leinonen A, Barker D, Gregory M, Atkin CL, Netzer KO, Weber M, Reeders S, Grönhagen-Riska C, Neumann HP, Trembath R, Tryggvason K. Identification of 17 mutations in ten exons in the COL4A5 collagen gene, but no mutations found in four exons in COL4A6: a study of 250 patients with hematuria and suspected of having Alport syndrome. J Am Soc Nephrol. 1996 May; 7(5):702-9.
    View in: PubMed
  70. Zhang X, Zhou J, Reeders ST, Tryggvason K. Structure of the human type IV collagen COL4A6 gene, which is mutated in Alport syndrome-associated leiomyomatosis. Genomics. 1996 May 1; 33(3):473-9.
    View in: PubMed
  71. Dahan K, Heidet L, Zhou J, Mettler G, Leppig KA, Proesmans W, David A, Roussel B, Mongeau JG, Gould JM, et al. Smooth muscle tumors associated with X-linked Alport syndrome: carrier detection in females. Kidney Int. 1995 Dec; 48(6):1900-6.
    View in: PubMed
  72. Polycystic kidney disease: the complete structure of the PKD1 gene and its protein. The International Polycystic Kidney Disease Consortium. Cell. 1995 Apr 21; 81(2):289-98.
    View in: PubMed
  73. Heidet L, Dahan K, Zhou J, Xu Z, Cochat P, Gould JD, Leppig KA, Proesmans W, Guyot C, Guillot M, et al. Deletions of both alpha 5(IV) and alpha 6(IV) collagen genes in Alport syndrome and in Alport syndrome associated with smooth muscle tumours. Hum Mol Genet. 1995 Jan; 4(1):99-108.
    View in: PubMed
  74. Boye E, Flinter F, Zhou J, Tryggvason K, Bobrow M, Harris A. Detection of 12 novel mutations in the collagenous domain of the COL4A5 gene in Alport syndrome patients. Hum Mutat. 1995; 5(3):197-204.
    View in: PubMed
  75. Hertz JM, Heiskari N, Zhou J, Jensen UB, Tryggvason K. A nonsense mutation in the COL4A5 collagen gene in a family with X-linked juvenile Alport syndrome. Kidney Int. 1995 Jan; 47(1):327-32.
    View in: PubMed
  76. Ding J, Zhou J, Tryggvason K, Kashtan CE. COL4A5 deletions in three patients with Alport syndrome and posttransplant antiglomerular basement membrane nephritis. J Am Soc Nephrol. 1994 Aug; 5(2):161-8.
    View in: PubMed
  77. Zhou J, Ding M, Zhao Z, Reeders ST. Complete primary structure of the sixth chain of human basement membrane collagen, alpha 6(IV). Isolation of the cDNAs for alpha 6(IV) and comparison with five other type IV collagen chains. J Biol Chem. 1994 May 6; 269(18):13193-9.
    View in: PubMed
  78. Zhou J, Leinonen A, Tryggvason K. Structure of the human type IV collagen COL4A5 gene. J Biol Chem. 1994 Mar 4; 269(9):6608-14.
    View in: PubMed
  79. Antignac C, Knebelmann B, Drouot L, Gros F, Deschênes G, Hors-Cayla MC, Zhou J, Tryggvason K, Grünfeld JP, Broyer M, et al. Deletions in the COL4A5 collagen gene in X-linked Alport syndrome. Characterization of the pathological transcripts in nonrenal cells and correlation with disease expression. J Clin Invest. 1994 Mar; 93(3):1195-207.
    View in: PubMed
  80. Zhou J, Mochizuki T, Smeets H, Antignac C, Laurila P, de Paepe A, Tryggvason K, Reeders ST. Deletion of the paired alpha 5(IV) and alpha 6(IV) collagen genes in inherited smooth muscle tumors. Science. 1993 Aug 27; 261(5125):1167-9.
    View in: PubMed
  81. Lemmink HH, Schröder CH, Brunner HG, Nelen MR, Zhou J, Tryggvason K, Haagsma-Schouten WA, Roodvoets AP, Rascher W, van Oost BA, et al. Identification of four novel mutations in the COL4A5 gene of patients with Alport syndrome. Genomics. 1993 Aug; 17(2):485-9.
    View in: PubMed
  82. Zhou J, Gregory MC, Hertz JM, Barker DF, Atkin C, Spencer ES, Tryggvason K. Mutations in the codon for a conserved arginine-1563 in the COL4A5 collagen gene in Alport syndrome. Kidney Int. 1993 Mar; 43(3):722-9.
    View in: PubMed
  83. Netzer KO, Pullig O, Frei U, Zhou J, Tryggvason K, Weber M. COL4A5 splice site mutation and alpha 5(IV) collagen mRNA in Alport syndrome. Kidney Int. 1993 Feb; 43(2):486-92.
    View in: PubMed
  84. Nadkarni PM, Reeders ST, Zhou J. CECIL: a database for storing and retrieving clinical and molecular information on patients with Alport syndrome. Proc Annu Symp Comput Appl Med Care. 1993; 649-53.
    View in: PubMed
  85. Tryggvason K, Zhou J, Hostikka SL, Shows TB. Molecular genetics of Alport syndrome. Kidney Int. 1993 Jan; 43(1):38-44.
    View in: PubMed
  86. M'Rad R, Sanak M, Deschenes G, Zhou J, Bonaiti-Pellie C, Holvoet-Vermaut L, Heuertz S, Gubler MC, Broyer M, Grunfeld JP, et al. Alport syndrome: a genetic study of 31 families. Hum Genet. 1992 Dec; 90(4):420-6.
    View in: PubMed
  87. Netzer KO, Renders L, Zhou J, Pullig O, Tryggvason K, Weber M. Deletions of the COL4A5 gene in patients with Alport syndrome. Kidney Int. 1992 Dec; 42(6):1336-44.
    View in: PubMed
  88. Antignac C, Zhou J, Sanak M, Cochat P, Roussel B, Deschênes G, Gros F, Knebelmann B, Hors-Cayla MC, Tryggvason K, et al. Alport syndrome and diffuse leiomyomatosis: deletions in the 5' end of the COL4A5 collagen gene. Kidney Int. 1992 Nov; 42(5):1178-83.
    View in: PubMed
  89. Smeets HJ, Melenhorst JJ, Lemmink HH, Schröder CH, Nelen MR, Zhou J, Hostikka SL, Tryggvason K, Ropers HH, Jansweijer MC, et al. Different mutations in the COL4A5 collagen gene in two patients with different features of Alport syndrome. Kidney Int. 1992 Jul; 42(1):83-8.
    View in: PubMed
  90. Knebelmann B, Deschenes G, Gros F, Hors MC, Grünfeld JP, Zhou J, Tryggvason K, Gubler MC, Antignac C. Substitution of arginine for glycine 325 in the collagen alpha 5 (IV) chain associated with X-linked Alport syndrome: characterization of the mutation by direct sequencing of PCR-amplified lymphoblast cDNA fragments. Am J Hum Genet. 1992 Jul; 51(1):135-42.
    View in: PubMed
  91. Zhou J, Hertz JM, Leinonen A, Tryggvason K. Complete amino acid sequence of the human alpha 5 (IV) collagen chain and identification of a single-base mutation in exon 23 converting glycine 521 in the collagenous domain to cysteine in an Alport syndrome patient. J Biol Chem. 1992 Jun 25; 267(18):12475-81.
    View in: PubMed
  92. Zhou J, Hertz JM, Tryggvason K. Mutation in the alpha 5(IV) collagen chain in juvenile-onset Alport syndrome without hearing loss or ocular lesions: detection by denaturing gradient gel electrophoresis of a PCR product. Am J Hum Genet. 1992 Jun; 50(6):1291-300.
    View in: PubMed
  93. Zhou J, Hostikka SL, Chow LT, Tryggvason K. Characterization of the 3' half of the human type IV collagen alpha 5 gene that is affected in the Alport syndrome. Genomics. 1991 Jan; 9(1):1-9.
    View in: PubMed
  94. Zhou J, Barker DF, Hostikka SL, Gregory MC, Atkin CL, Tryggvason K. Single base mutation in alpha 5(IV) collagen chain gene converting a conserved cysteine to serine in Alport syndrome. Genomics. 1991 Jan; 9(1):10-8.
    View in: PubMed
  95. Barker DF, Hostikka SL, Zhou J, Chow LT, Oliphant AR, Gerken SC, Gregory MC, Skolnick MH, Atkin CL, Tryggvason K. Identification of mutations in the COL4A5 collagen gene in Alport syndrome. Science. 1990 Jun 8; 248(4960):1224-7.
    View in: PubMed
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