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Last Name
Institution

Lester Kobzik, M.D.

TitleProfessor in the Department of Environmental Health
InstitutionHarvard School of Public Health
DepartmentEH - Molecular+Integrative Phys Sci Prog
AddressBrigham and Women's Hospital
Pathology
75 Francis St
Boston MA 02115
Phone617/432-2247
Fax617/432-3468
Other Positions
TitleProfessor of Pathology
InstitutionBrigham and Women's Hospital
DepartmentPathology


 Research 
 research resources
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 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kobzik L, Swirski FK. MARCOing Monocytes for Elimination. Sci Transl Med. 2014 Jan 15; 6(219):219fs4.
    View in: PubMed
  2. Gaughan DM, Christiani DC, Hughes MD, Baur DM, Kobzik L, Wagner GR, Kales SN. High hsCRP is associated with reduced lung function in structural firefighters. Am J Ind Med. 2014 Jan; 57(1):31-7.
    View in: PubMed
  3. Gregory DJ, Zhang Y, Kobzik L, Fedulov AV. Specific transcriptional enhancement of inducible nitric oxide synthase by targeted promoter demethylation. Epigenetics. 2013 Nov 1; 8(11):1205-12.
    View in: PubMed
  4. Mikhaylova L, Zhang Y, Kobzik L, Fedulov AV. Link between Epigenomic Alterations and Genome-Wide Aberrant Transcriptional Response to Allergen in Dendritic Cells Conveying Maternal Asthma Risk. PLoS One. 2013; 8(8):e70387.
    View in: PubMed
  5. Kasahara DI, Williams AS, Benedito LA, Ranscht B, Kobzik L, Hug C, Shore SA. Role of the Adiponectin Binding Protein, T-Cadherin (cdh13), in Pulmonary Responses to Subacute Ozone. PLoS One. 2013; 8(6):e65829.
    View in: PubMed
  6. Knolle MD, Nakajima T, Hergrueter A, Gupta K, Polverino F, Craig VJ, Fyfe SE, Zahid M, Permaul P, Cernadas M, Montano G, Tesfaigzi Y, Sholl L, Kobzik L, Israel E, Owen CA. Adam8 limits the development of allergic airway inflammation in mice. J Immunol. 2013 Jun 15; 190(12):6434-49.
    View in: PubMed
  7. Jing J, Yang IV, Hui L, Patel JA, Evans CM, Prikeris R, Kobzik L, O'Connor BP, Schwartz DA. Role of macrophage receptor with collagenous structure in innate immune tolerance. J Immunol. 2013 Jun 15; 190(12):6360-7.
    View in: PubMed
  8. Park JA, Sharif AS, Shiomi T, Kobzik L, Kasahara DI, Tschumperlin DJ, Voynow J, Drazen JM. Human neutrophil elastase-mediated goblet cell metaplasia is attenuated in TACE-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2013 May; 304(10):L701-7.
    View in: PubMed
  9. Craig VJ, Quintero PA, Fyfe SE, Patel AS, Knolle MD, Kobzik L, Owen CA. Profibrotic Activities for Matrix Metalloproteinase-8 during Bleomycin-Mediated Lung Injury. J Immunol. 2013 Apr 15; 190(8):4283-96.
    View in: PubMed
  10. Macleod DT, Nakatsuji T, Yamasaki K, Kobzik L, Gallo RL. HSV-1 exploits the innate immune scavenger receptor MARCO to enhance epithelial adsorption and infection. Nat Commun. 2013; 4:1963.
    View in: PubMed
  11. Petnicki-Ocwieja T, Chung E, Acosta DI, Ramos LT, Shin OS, Ghosh S, Kobzik L, Li X, Hu LT. TRIF Mediates Toll-Like Receptor 2-Dependent Inflammatory Responses to Borrelia burgdorferi. Infect Immun. 2013 Feb; 81(2):402-10.
    View in: PubMed
  12. Thomsen M, Nordestgaard BG, Kobzik L, Dahl M. Genetic Variation in the Scavenger Receptor MARCO and Its Association with Chronic Obstructive Pulmonary Disease and Lung Infection in 10,604 Individuals. Respiration. 2013; 85(2):144-53.
    View in: PubMed
  13. Sun X, Icli B, Wara AK, Belkin N, He S, Kobzik L, Hunninghake GM, Vera MP, Blackwell TS, Baron RM, Feinberg MW. MicroRNA-181b regulates NF-?B-mediated vascular inflammation. J Clin Invest. 2012 Jun 1; 122(6):1973-90.
    View in: PubMed
  14. Cho HY, van Houten B, Wang X, Miller-DeGraff L, Fostel J, Gladwell W, Perrow L, Panduri V, Kobzik L, Yamamoto M, Bell DA, Kleeberger SR. Targeted deletion of nrf2 impairs lung development and oxidant injury in neonatal mice. Antioxid Redox Signal. 2012 Oct 15; 17(8):1066-82.
    View in: PubMed
  15. Zhou H, DeLoid G, Browning E, Gregory DJ, Tan F, Bedugnis AS, Imrich A, Koziel H, Kramnik I, Lu Q, Kobzik L. Genome-wide RNAi screen in IFN-?-treated human macrophages identifies genes mediating resistance to the intracellular pathogen Francisella tularensis. PLoS One. 2012; 7(2):e31752.
    View in: PubMed
  16. Józefowski S, Yang Z, Marcinkiewicz J, Kobzik L. Scavenger receptors and ß-glucan receptors participate in the recognition of yeasts by murine macrophages. Inflamm Res. 2012 Feb; 61(2):113-26.
    View in: PubMed
  17. Myatt TA, Vincent MS, Kobzik L, Naeher LP, MacIntosh DL, Suh H. Markers of inflammation in alveolar cells exposed to fine particulate matter from prescribed fires and urban air. J Occup Environ Med. 2011 Oct; 53(10):1110-4.
    View in: PubMed
  18. Sever-Chroneos Z, Murthy A, Davis J, Florence JM, Kurdowska A, Krupa A, Tichelaar JW, White MR, Hartshorn KL, Kobzik L, Whitsett JA, Chroneos ZC. GM-CSF modulates pulmonary resistance to influenza A infection. Antiviral Res. 2011 Nov; 92(2):319-28.
    View in: PubMed
  19. Ghosh S, Gregory D, Smith A, Kobzik L. MARCO regulates early inflammatory responses against influenza: a useful macrophage function with adverse outcome. Am J Respir Cell Mol Biol. 2011 Nov; 45(5):1036-44.
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  20. Sever-Chroneos Z, Krupa A, Davis J, Hasan M, Yang CH, Szeliga J, Herrmann M, Hussain M, Geisbrecht BV, Kobzik L, Chroneos ZC. Surfactant protein A (SP-A)-mediated clearance of Staphylococcus aureus involves binding of SP-A to the staphylococcal adhesin eap and the macrophage receptors SP-A receptor 210 and scavenger receptor class A. J Biol Chem. 2011 Feb 11; 286(6):4854-70.
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  21. Thelen T, Hao Y, Medeiros AI, Curtis JL, Serezani CH, Kobzik L, Harris LH, Aronoff DM. The class A scavenger receptor, macrophage receptor with collagenous structure, is the major phagocytic receptor for Clostridium sordellii expressed by human decidual macrophages. J Immunol. 2010 Oct 1; 185(7):4328-35.
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  22. Lim RH, Kobzik L, Dahl M. Risk for asthma in offspring of asthmatic mothers versus fathers: a meta-analysis. PLoS One. 2010; 5(4):e10134.
    View in: PubMed
  23. Fedulov AV, Kobzik L. Allergy risk is mediated by dendritic cells with congenital epigenetic changes. Am J Respir Cell Mol Biol. 2011 Mar; 44(3):285-92.
    View in: PubMed
  24. Lamoureux DP, Kobzik L, Fedulov AV. Customized PCR-array analysis informed by gene-chip microarray and biological hypothesis reveals pathways involved in lung inflammatory response to titanium dioxide in pregnancy. J Toxicol Environ Health A. 2010; 73(9):596-606.
    View in: PubMed
  25. DeLoid GM, Sulahian TH, Imrich A, Kobzik L. Heterogeneity in macrophage phagocytosis of Staphylococcus aureus strains: high-throughput scanning cytometry-based analysis. PLoS One. 2009; 4(7):e6209.
    View in: PubMed
  26. Kobzik L. Translating NO biology into clinical advances: still searching for the right dictionary? Am J Respir Cell Mol Biol. 2009 Jul; 41(1):9-13.
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  27. Pichugin AV, Yan BS, Sloutsky A, Kobzik L, Kramnik I. Dominant role of the sst1 locus in pathogenesis of necrotizing lung granulomas during chronic tuberculosis infection and reactivation in genetically resistant hosts. Am J Pathol. 2009 Jun; 174(6):2190-201.
    View in: PubMed
  28. Wright AK, Rao S, Range S, Eder C, Hofer TP, Frankenberger M, Kobzik L, Brightling C, Grigg J, Ziegler-Heitbrock L. Pivotal Advance: Expansion of small sputum macrophages in CF: failure to express MARCO and mannose receptors. J Leukoc Biol. 2009 Sep; 86(3):479-89.
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  29. Lim RH, Kobzik L. Transplacental passage of interleukins 4 and 13? PLoS One. 2009; 4(3):e4660.
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  30. Lim RH, Kobzik L. Maternal transmission of asthma risk. Am J Reprod Immunol. 2009 Jan; 61(1):1-10.
    View in: PubMed
  31. Winkler AR, Nocka KH, Sulahian TH, Kobzik L, Williams CM. In vitro modeling of human alveolar macrophage smoke exposure: enhanced inflammation and impaired function. Exp Lung Res. 2008 Nov; 34(9):599-629.
    View in: PubMed
  32. Fedulov AV, Kobzik L. Immunotoxicologic analysis of maternal transmission of asthma risk. J Immunotoxicol. 2008 Oct; 5(4):445-52.
    View in: PubMed
  33. Sulahian TH, Imrich A, Deloid G, Winkler AR, Kobzik L. Signaling pathways required for macrophage scavenger receptor-mediated phagocytosis: analysis by scanning cytometry. Respir Res. 2008; 9:59.
    View in: PubMed
  34. Zhou H, Imrich A, Kobzik L. Characterization of immortalized MARCO and SR-AI/II-deficient murine alveolar macrophage cell lines. Part Fibre Toxicol. 2008; 5:7.
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  35. Lim RH, Kobzik L. Sexual tension in the airways: the puzzling duality of estrogen in asthma. Am J Respir Cell Mol Biol. 2008 May; 38(5):499-500.
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  36. Yan BS, Pichugin AV, Jobe O, Helming L, Eruslanov EB, Gutiérrez-Pabello JA, Rojas M, Shebzukhov YV, Kobzik L, Kramnik I. Progression of pulmonary tuberculosis and efficiency of bacillus Calmette-Guérin vaccination are genetically controlled via a common sst1-mediated mechanism of innate immunity. J Immunol. 2007 Nov 15; 179(10):6919-32.
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  37. Limmon GV, Arredouani M, McCann KL, Corn Minor RA, Kobzik L, Imani F. Scavenger receptor class-A is a novel cell surface receptor for double-stranded RNA. FASEB J. 2008 Jan; 22(1):159-67.
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  38. Fedulov AV, Leme AS, Kobzik L. Duration of allergic susceptibility in maternal transmission of asthma risk. Am J Reprod Immunol. 2007 Aug; 58(2):120-8.
    View in: PubMed
  39. Lim RH, Arredouani MS, Fedulov A, Kobzik L, Hubeau C. Maternal allergic contact dermatitis causes increased asthma risk in offspring. Respir Res. 2007; 8:56.
    View in: PubMed
  40. Fedulov AV, Leme A, Yang Z, Dahl M, Lim R, Mariani TJ, Kobzik L. Pulmonary exposure to particles during pregnancy causes increased neonatal asthma susceptibility. Am J Respir Cell Mol Biol. 2008 Jan; 38(1):57-67.
    View in: PubMed
  41. Sigaud S, Goldsmith CA, Zhou H, Yang Z, Fedulov A, Imrich A, Kobzik L. Air pollution particles diminish bacterial clearance in the primed lungs of mice. Toxicol Appl Pharmacol. 2007 Aug 15; 223(1):1-9.
    View in: PubMed
  42. Arredouani MS, Franco F, Imrich A, Fedulov A, Lu X, Perkins D, Soininen R, Tryggvason K, Shapiro SD, Kobzik L. Scavenger Receptors SR-AI/II and MARCO limit pulmonary dendritic cell migration and allergic airway inflammation. J Immunol. 2007 May 1; 178(9):5912-20.
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  43. Hamada K, Suzaki Y, Leme A, Ito T, Miyamoto K, Kobzik L, Kimura H. Exposure of pregnant mice to an air pollutant aerosol increases asthma susceptibility in offspring. J Toxicol Environ Health A. 2007 Apr 15; 70(8):688-95.
    View in: PubMed
  44. Dahl M, Bauer AK, Arredouani M, Soininen R, Tryggvason K, Kleeberger SR, Kobzik L. Protection against inhaled oxidants through scavenging of oxidized lipids by macrophage receptors MARCO and SR-AI/II. J Clin Invest. 2007 Mar; 117(3):757-64.
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  45. Hubeau C, Apostolou I, Kobzik L. Targeting of CD25 and glucocorticoid-induced TNF receptor family-related gene-expressing T cells differentially modulates asthma risk in offspring of asthmatic and normal mother mice. J Immunol. 2007 Feb 1; 178(3):1477-87.
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  46. Imrich A, Ning Y, Lawrence J, Coull B, Gitin E, Knutson M, Kobzik L. Alveolar macrophage cytokine response to air pollution particles: oxidant mechanisms. Toxicol Appl Pharmacol. 2007 Feb 1; 218(3):256-64.
    View in: PubMed
  47. Zhou H, Kobzik L. Effect of concentrated ambient particles on macrophage phagocytosis and killing of Streptococcus pneumoniae. Am J Respir Cell Mol Biol. 2007 Apr; 36(4):460-5.
    View in: PubMed
  48. Józefowski S, Sulahian TH, Arredouani M, Kobzik L. Role of scavenger receptor MARCO in macrophage responses to CpG oligodeoxynucleotides. J Leukoc Biol. 2006 Oct; 80(4):870-9.
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  49. Hubeau C, Apostolou I, Kobzik L. Adoptively transferred allergen-specific T cells cause maternal transmission of asthma risk. Am J Pathol. 2006 Jun; 168(6):1931-9.
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  50. Arredouani MS, Yang Z, Imrich A, Ning Y, Qin G, Kobzik L. The macrophage scavenger receptor SR-AI/II and lung defense against pneumococci and particles. Am J Respir Cell Mol Biol. 2006 Oct; 35(4):474-8.
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  51. Martens JH, Kzhyshkowska J, Falkowski-Hansen M, Schledzewski K, Gratchev A, Mansmann U, Schmuttermaier C, Dippel E, Koenen W, Riedel F, Sankala M, Tryggvason K, Kobzik L, Moldenhauer G, Arnold B, Goerdt S. Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in human lymph node sinuses, the primary sites of regional metastasis. J Pathol. 2006 Mar; 208(4):574-89.
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  52. Leme AS, Hubeau C, Xiang Y, Goldman A, Hamada K, Suzaki Y, Kobzik L. Role of breast milk in a mouse model of maternal transmission of asthma susceptibility. J Immunol. 2006 Jan 15; 176(2):762-9.
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  53. Józefowski S, Arredouani M, Sulahian T, Kobzik L. Disparate regulation and function of the class A scavenger receptors SR-AI/II and MARCO. J Immunol. 2005 Dec 15; 175(12):8032-41.
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  54. Suzaki Y, Hamada K, Sho M, Ito T, Miyamoto K, Akashi S, Kashizuka H, Ikeda N, Nakajima Y, Iwase M, Homma I, Kobzik L, Kimura H. A potent antiangiogenic factor, endostatin prevents the development of asthma in a murine model. J Allergy Clin Immunol. 2005 Dec; 116(6):1220-7.
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  55. Arredouani MS, Palecanda A, Koziel H, Huang YC, Imrich A, Sulahian TH, Ning YY, Yang Z, Pikkarainen T, Sankala M, Vargas SO, Takeya M, Tryggvason K, Kobzik L. MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages. J Immunol. 2005 Nov 1; 175(9):6058-64.
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  56. Fedulov A, Silverman E, Xiang Y, Leme A, Kobzik L. Immunostimulatory CpG oligonucleotides abrogate allergic susceptibility in a murine model of maternal asthma transmission. J Immunol. 2005 Oct 1; 175(7):4292-300.
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  57. Pan H, Yan BS, Rojas M, Shebzukhov YV, Zhou H, Kobzik L, Higgins DE, Daly MJ, Bloom BR, Kramnik I. Ipr1 gene mediates innate immunity to tuberculosis. Nature. 2005 Apr 7; 434(7034):767-72.
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  58. Gerbitz A, Nickoloff BJ, Olkiewicz K, Willmarth NE, Hildebrandt G, Liu C, Kobzik L, Eissner G, Holler E, Ferrara JL, Cooke KR. A role for tumor necrosis factor-alpha-mediated endothelial apoptosis in the development of experimental idiopathic pneumonia syndrome. Transplantation. 2004 Aug 27; 78(4):494-502.
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  59. Józefowski S, Kobzik L. Scavenger receptor A mediates H2O2 production and suppression of IL-12 release in murine macrophages. J Leukoc Biol. 2004 Nov; 76(5):1066-74.
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  60. Arredouani M, Yang Z, Ning Y, Qin G, Soininen R, Tryggvason K, Kobzik L. The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles. J Exp Med. 2004 Jul 19; 200(2):267-72.
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  61. Bunn HJ, Kobzik L, Grigg J. MARCO expression on pediatric alveolar macrophages. Cytometry B Clin Cytom. 2004 Jul; 60(1):54-6.
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  62. Hjoberg J, Shore S, Kobzik L, Okinaga S, Hallock A, Vallone J, Subramaniam V, De Sanctis GT, Elias JA, Drazen JM, Silverman ES. Expression of nitric oxide synthase-2 in the lungs decreases airway resistance and responsiveness. J Appl Physiol. 2004 Jul; 97(1):249-59.
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  63. Oyama J, Blais C, Liu X, Pu M, Kobzik L, Kelly RA, Bourcier T. Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice. Circulation. 2004 Feb 17; 109(6):784-9.
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  64. Arredouani MS, Kobzik L. The structure and function of marco, a macrophage class a scavenger receptor. Cell Mol Biol (Noisy-le-grand). 2004; 50 Online Pub:OL657-65.
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  65. Ning Y, Tao F, Qin G, Imrich A, Goldsmith CA, Yang Z, Kobzik L. Particle-epithelial interaction: effect of priming and bystander neutrophils on interleukin-8 release. Am J Respir Cell Mol Biol. 2004 May; 30(5):744-50.
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  66. Tao F, Gonzalez-Flecha B, Kobzik L. Reactive oxygen species in pulmonary inflammation by ambient particulates. Free Radic Biol Med. 2003 Aug 15; 35(4):327-40.
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  67. Mizgerd JP, Lupa MM, Kogan MS, Warren HB, Kobzik L, Topulos GP. Nuclear factor-kappaB p50 limits inflammation and prevents lung injury during Escherichia coli pneumonia. Am J Respir Crit Care Med. 2003 Oct 1; 168(7):810-7.
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  68. Frantz S, Ducharme A, Sawyer D, Rohde LE, Kobzik L, Fukazawa R, Tracey D, Allen H, Lee RT, Kelly RA. Targeted deletion of caspase-1 reduces early mortality and left ventricular dilatation following myocardial infarction. J Mol Cell Cardiol. 2003 Jun; 35(6):685-94.
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  69. Hamada K, Suzaki Y, Goldman A, Ning YY, Goldsmith C, Palecanda A, Coull B, Hubeau C, Kobzik L. Allergen-independent maternal transmission of asthma susceptibility. J Immunol. 2003 Feb 15; 170(4):1683-9.
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  70. Tao F, Palecanda A, Kumar S, Kobzik L. Generation of a monoclonal antibody that blocks epithelial binding of unopsonized particles. Hybrid Hybridomics. 2003 Feb; 22(1):17-21.
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  71. Austen WG, Kobzik L, Carroll MC, Hechtman HB, Moore FD. The role of complement and natural antibody in intestinal ischemia-reperfusion injury. Int J Immunopathol Pharmacol. 2003 Jan-Apr; 16(1):1-8.
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  72. Reid RR, Woodcock S, Shimabukuro-Vornhagen A, Austen WG, Kobzik L, Zhang M, Hechtman HB, Moore FD, Carroll MC. Functional activity of natural antibody is altered in Cr2-deficient mice. J Immunol. 2002 Nov 15; 169(10):5433-40.
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  73. Hamada K, Goldsmith CA, Suzaki Y, Goldman A, Kobzik L. Airway hyperresponsiveness caused by aerosol exposure to residual oil fly ash leachate in mice. J Toxicol Environ Health A. 2002 Sep 27; 65(18):1351-65.
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  74. Goldsmith CA, Ning Y, Qin G, Imrich A, Lawrence J, Murthy GG, Catalano PJ, Kobzik L. Combined air pollution particle and ozone exposure increases airway responsiveness in mice. Inhal Toxicol. 2002 Apr; 14(4):325-47.
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  75. Tao F, Kobzik L. Lung macrophage-epithelial cell interactions amplify particle-mediated cytokine release. Am J Respir Cell Mol Biol. 2002 Apr; 26(4):499-505.
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  76. Kobzik L, Goldsmith CA, Ning YY, Qin G, Morgan B, Imrich A, Lawrence J, Murthy GG, Catalano PJ. Effects of combined ozone and air pollution particle exposure in mice. Res Rep Health Eff Inst. 2001 Dec; (106):5-29; discussion 31-8.
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  77. Kyriakides C, Wang Y, Austen WG, Favuzza J, Kobzik L, Moore FD, Hechtman HB. Sialyl Lewis(x) hybridized complement receptor type 1 moderates acid aspiration injury. Am J Physiol Lung Cell Mol Physiol. 2001 Dec; 281(6):L1494-9.
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  78. Palecanda A, Kobzik L. Receptors for unopsonized particles: the role of alveolar macrophage scavenger receptors. Curr Mol Med. 2001 Nov; 1(5):589-95.
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  79. Long CM, Suh HH, Kobzik L, Catalano PJ, Ning YY, Koutrakis P. A pilot investigation of the relative toxicity of indoor and outdoor fine particles: in vitro effects of endotoxin and other particulate properties. Environ Health Perspect. 2001 Oct; 109(10):1019-26.
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  80. Kyriakides C, Austen WG, Wang Y, Favuzza J, Kobzik L, Moore FD, Hechtman HB. Mast cells mediate complement activation after acid aspiration. Shock. 2001 Jul; 16(1):21-4.
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  81. Kyriakides C, Wang Y, Austen WG, Favuzza J, Kobzik L, Moore FD, Hechtman HB. Moderation of skeletal muscle reperfusion injury by a sLe(x)-glycosylated complement inhibitory protein. Am J Physiol Cell Physiol. 2001 Jul; 281(1):C224-30.
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  82. Moniotte S, Kobzik L, Feron O, Trochu JN, Gauthier C, Balligand JL. Upregulation of beta(3)-adrenoceptors and altered contractile response to inotropic amines in human failing myocardium. Circulation. 2001 Mar 27; 103(12):1649-55.
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  83. Cooke KR, Hill GR, Gerbitz A, Kobzik L, Martin TR, Crawford JM, Brewer JP, Ferrara JL. Hyporesponsiveness of donor cells to lipopolysaccharide stimulation reduces the severity of experimental idiopathic pneumonia syndrome: potential role for a gut-lung axis of inflammation. J Immunol. 2000 Dec 1; 165(11):6612-9.
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  84. Imrich A, Ning Y, Kobzik L. Insoluble components of concentrated air particles mediate alveolar macrophage responses in vitro. Toxicol Appl Pharmacol. 2000 Sep 1; 167(2):140-50.
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  85. Kyriakides C, Woodcock SA, Wang Y, Favuzza J, Austen WG, Kobzik L, Moore FD, Valeri RC, Shepro D, Hechtman HB. Soluble P-selectin moderates complement-dependent reperfusion injury of ischemic skeletal muscle. Am J Physiol Cell Physiol. 2000 Aug; 279(2):C520-8.
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  86. Cooke KR, Hill GR, Gerbitz A, Kobzik L, Martin TR, Crawford JM, Brewer JP, Ferrara JL. Tumor necrosis factor-alpha neutralization reduces lung injury after experimental allogeneic bone marrow transplantation. Transplantation. 2000 Jul 27; 70(2):272-9.
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  87. Palecanda A, Kobzik L. Alveolar macrophage-environmental particle interaction: analysis by flow cytometry. Methods. 2000 Jul; 21(3):241-7.
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  88. Hamada K, Goldsmith CA, Goldman A, Kobzik L. Resistance of very young mice to inhaled allergen sensitization is overcome by coexposure to an air-pollutant aerosol. Am J Respir Crit Care Med. 2000 Apr; 161(4 Pt 1):1285-93.
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  89. Mark DA, Donovan CE, De Sanctis GT, He HZ, Cernadas M, Kobzik L, Perkins DL, Sharpe A, Finn PW. B7-1 (CD80) and B7-2 (CD86) have complementary roles in mediating allergic pulmonary inflammation and airway hyperresponsiveness. Am J Respir Cell Mol Biol. 2000 Mar; 22(3):265-71.
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  90. Ning Y, Imrich A, Goldsmith CA, Qin G, Kobzik L. Alveolar macrophage cytokine production in response to air particles in vitro: role of endotoxin. J Toxicol Environ Health A. 2000 Feb 11; 59(3):165-80.
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  91. Hamada K, Teramoto S, Narita N, Yamada E, Teramoto K, Kobzik L. Pulmonary veno-occlusive disease in pulmonary Langerhans' cell granulomatosis. Eur Respir J. 2000 Feb; 15(2):421-3.
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  92. Qin G, Taylor M, Ning YY, Iversen P, Kobzik L. In vivo evaluation of a morpholino antisense oligomer directed against tumor necrosis factor-alpha. Antisense Nucleic Acid Drug Dev. 2000 Feb; 10(1):11-6.
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  93. Swanson SJ, Mentzer SJ, Reilly JJ, Bueno R, Lukanich JM, Jaklitsch MT, Kobzik L, Ingenito EP, Fuhlbrigge A, Donovan C, McKee C, Boyle K, Fagan GP, Sugarbaker DJ. Surveillance transbronchial lung biopsies: implication for survival after lung transplantation. J Thorac Cardiovasc Surg. 2000 Jan; 119(1):27-37.
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  94. Reid RR, Woodcock S, Prodeus AP, Austen J, Kobzik L, Hechtman H, Moore FD, Carroll MC. The role of complement receptors CD21/CD35 in positive selection of B-1 cells. Curr Top Microbiol Immunol. 2000; 252:57-65.
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  95. Donovan CE, Mark DA, He HZ, Liou HC, Kobzik L, Wang Y, De Sanctis GT, Perkins DL, Finn PW. NF-kappa B/Rel transcription factors: c-Rel promotes airway hyperresponsiveness and allergic pulmonary inflammation. J Immunol. 1999 Dec 15; 163(12):6827-33.
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  96. Kyriakides C, Austen W, Wang Y, Favuzza J, Kobzik L, Moore FD, Hechtman HB. Skeletal muscle reperfusion injury is mediated by neutrophils and the complement membrane attack complex. Am J Physiol. 1999 Dec; 277(6 Pt 1):C1263-8.
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  97. Kyriakides C, Austen W, Wang Y, Favuzza J, Kobzik L, Moore FD, Hechtman HB. Membrane attack complex of complement and neutrophils mediate the injury of acid aspiration. J Appl Physiol. 1999 Dec; 87(6):2357-61.
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  98. Goldsmith CA, Hamada K, Ning Y, Qin G, Catalano P, Krishna Murthy GG, Lawrence J, Kobzik L. Effects of environmental aerosols on airway hyperresponsiveness in a murine model of asthma. Inhal Toxicol. 1999 Nov; 11(11):981-98.
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  99. Hamada K, Goldsmith CA, Kobzik L. Increased airway hyperresponsiveness and inflammation in a juvenile mouse model of asthma exposed to air-pollutant aerosol. J Toxicol Environ Health A. 1999 Oct 15; 58(3):129-43.
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  100. Imrich A, Ning YY, Koziel H, Coull B, Kobzik L. Lipopolysaccharide priming amplifies lung macrophage tumor necrosis factor production in response to air particles. Toxicol Appl Pharmacol. 1999 Sep 1; 159(2):117-24.
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  101. Austen WG, Kyriakides C, Favuzza J, Wang Y, Kobzik L, Moore FD, Hechtman HB. Intestinal ischemia-reperfusion injury is mediated by the membrane attack complex. Surgery. 1999 Aug; 126(2):343-8.
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  102. Frantz S, Kobzik L, Kim YD, Fukazawa R, Medzhitov R, Lee RT, Kelly RA. Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium. J Clin Invest. 1999 Aug; 104(3):271-80.
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  103. Goldsmith CA, Kobzik L. Particulate air pollution and asthma: a review of epidemiological and biological studies. Rev Environ Health. 1999 Jul-Sep; 14(3):121-34.
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  104. Wong MS, Lara TM, Kobzik L, Rounds JD, Robinson MK, Jacobs DO. Hindlimb ischemia-reperfusion increases complement deposition and glycolysis. J Surg Res. 1999 Jul; 85(1):130-5.
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  105. Long NC, Abraham J, Kobzik L, Weller EA, Krishna Murthy GG, Shore SA. Respiratory tract inflammation during the induction of chronic bronchitis in rats: role of C-fibres. Eur Respir J. 1999 Jul; 14(1):46-56.
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  106. De Sanctis GT, MacLean JA, Hamada K, Mehta S, Scott JA, Jiao A, Yandava CN, Kobzik L, Wolyniec WW, Fabian AJ, Venugopal CS, Grasemann H, Huang PL, Drazen JM. Contribution of nitric oxide synthases 1, 2, and 3 to airway hyperresponsiveness and inflammation in a murine model of asthma. J Exp Med. 1999 May 17; 189(10):1621-30.
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  107. Palecanda A, Paulauskis J, Al-Mutairi E, Imrich A, Qin G, Suzuki H, Kodama T, Tryggvason K, Koziel H, Kobzik L. Role of the scavenger receptor MARCO in alveolar macrophage binding of unopsonized environmental particles. J Exp Med. 1999 May 3; 189(9):1497-506.
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  108. Imrich A, Ning YY, Kobzik L. Intracellular oxidant production and cytokine responses in lung macrophages: evaluation of fluorescent probes. J Leukoc Biol. 1999 Apr; 65(4):499-507.
    View in: PubMed
  109. Yet SF, Perrella MA, Layne MD, Hsieh CM, Maemura K, Kobzik L, Wiesel P, Christou H, Kourembanas S, Lee ME. Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice. J Clin Invest. 1999 Apr; 103(8):R23-9.
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  110. Williams JP, Pechet TT, Weiser MR, Reid R, Kobzik L, Moore FD, Carroll MC, Hechtman HB. Intestinal reperfusion injury is mediated by IgM and complement. J Appl Physiol. 1999 Mar; 86(3):938-42.
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  111. Cernadas M, De Sanctis GT, Krinzman SJ, Mark DA, Donovan CE, Listman JA, Kobzik L, Kikutani H, Christiani DC, Perkins DL, Finn PW. CD23 and allergic pulmonary inflammation: potential role as an inhibitor. Am J Respir Cell Mol Biol. 1999 Jan; 20(1):1-8.
    View in: PubMed
  112. Adler H, Beland JL, Del-Pan NC, Kobzik L, Sobel RA, Rimm IJ. In the absence of T cells, natural killer cells protect from mortality due to HSV-1 encephalitis. J Neuroimmunol. 1999 Jan 1; 93(1-2):208-13.
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  113. Farver CF, Kobzik L. Lung macrophage differentiation antigens in developing fetal and newborn rat lungs: A quantitative flow cytometric analysis with immunohistochemistry. Lung. 1999; 177(4):205-17.
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  114. Mark DA, Donovan CE, De Sanctis GT, Krinzman SJ, Kobzik L, Linsley PS, Sayegh MH, Lederer J, Perkins DL, Finn PW. Both CD80 and CD86 co-stimulatory molecules regulate allergic pulmonary inflammation. Int Immunol. 1998 Nov; 10(11):1647-55.
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  115. Adler H, Beland JL, Kozlow W, Del-Pan NC, Kobzik L, Rimm IJ. A role for transforming growth factor-beta1 in the increased pneumonitis in murine allogeneic bone marrow transplant recipients with graft-versus-host disease after pulmonary herpes simplex virus type 1 infection. Blood. 1998 Oct 1; 92(7):2581-9.
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  116. Gauthier C, Leblais V, Kobzik L, Trochu JN, Khandoudi N, Bril A, Balligand JL, Le Marec H. The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle. J Clin Invest. 1998 Oct 1; 102(7):1377-84.
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  117. Cooke KR, Krenger W, Hill G, Martin TR, Kobzik L, Brewer J, Simmons R, Crawford JM, van den Brink MR, Ferrara JL. Host reactive donor T cells are associated with lung injury after experimental allogeneic bone marrow transplantation. Blood. 1998 Oct 1; 92(7):2571-80.
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  118. Stringer B, Kobzik L. Environmental particulate-mediated cytokine production in lung epithelial cells (A549): role of preexisting inflammation and oxidant stress. J Toxicol Environ Health A. 1998 Sep 11; 55(1):31-44.
    View in: PubMed
  119. Goldsmith CA, Imrich A, Danaee H, Ning YY, Kobzik L. Analysis of air pollution particulate-mediated oxidant stress in alveolar macrophages. J Toxicol Environ Health A. 1998 Aug 7; 54(7):529-45.
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  120. Han X, Kobzik L, Severson D, Shimoni Y. Characteristics of nitric oxide-mediated cholinergic modulation of calcium current in rabbit sino-atrial node. J Physiol. 1998 Jun 15; 509 ( Pt 3):741-54.
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  121. Taylor MF, Weller DD, Kobzik L. Effect of TNF-alpha antisense oligomers on cytokine production by primary murine alveolar macrophages. Antisense Nucleic Acid Drug Dev. 1998 Jun; 8(3):199-205.
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  122. Stack AM, Malley R, Thompson CM, Kobzik L, Siber GR, Saladino RA. Minimum protective serum concentrations of pneumococcal anti-capsular antibodies in infant rats. J Infect Dis. 1998 Apr; 177(4):986-90.
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  123. Krause KM, Moody MR, Andrade FH, Taylor AA, Miller CC, Kobzik L, Reid MB. Peritonitis causes diaphragm weakness in rats. Am J Respir Crit Care Med. 1998 Apr; 157(4 Pt 1):1277-82.
    View in: PubMed
  124. Imrich A, Taylor M, Kobzik L. Fluorescence-based microplate bioassay for tumor necrosis factor. J Immunol Methods. 1998 Mar 1; 212(1):109-12.
    View in: PubMed
  125. Mari BP, Anderson IC, Mari SE, Ning Y, Lutz Y, Kobzik L, Shipp MA. Stromelysin-3 is induced in tumor/stroma cocultures and inactivated via a tumor-specific and basic fibroblast growth factor-dependent mechanism. J Biol Chem. 1998 Jan 2; 273(1):618-26.
    View in: PubMed
  126. Imrich A, Kobzik L. Flow cytometric analysis of macrophage oxidative metabolism using DCFH. Methods Mol Biol. 1998; 91:97-108.
    View in: PubMed
  127. Stringer B, Kobzik L. Measurement of environmental particulate uptake by lung cells using flow cytometry. Methods Mol Biol. 1998; 91:109-16.
    View in: PubMed
  128. Abraham RZ, Kobzik L, Moody MR, Reid MB, Stamler JS. Cyclic GMP is a second messenger by which nitric oxide inhibits diaphragm contraction. Comp Biochem Physiol A Mol Integr Physiol. 1998 Jan; 119(1):177-83.
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  129. Reid MB, Kobzik L, Bredt DS, Stamler JS. Nitric oxide modulates excitation-contraction coupling in the diaphragm. Comp Biochem Physiol A Mol Integr Physiol. 1998 Jan; 119(1):211-8.
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  130. Han X, Kobzik L, Zhao YY, Opel DJ, Liu WD, Kelly RA, Smith TW. Nitric oxide regulation of atrioventricular node excitability. Can J Cardiol. 1997 Dec; 13(12):1191-201.
    View in: PubMed
  131. Saladino RA, Stack AM, Fleisher GR, Thompson CM, Briles DE, Kobzik L, Siber GR. Development of a model of low-inoculum Streptococcus pneumoniae intrapulmonary infection in infant rats. Infect Immun. 1997 Nov; 65(11):4701-4.
    View in: PubMed
  132. Williams JP, Weiser MR, Pechet TT, Kobzik L, Moore FD, Hechtman HB. alpha 1-Acid glycoprotein reduces local and remote injuries after intestinal ischemia in the rat. Am J Physiol. 1997 Nov; 273(5 Pt 1):G1031-5.
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  133. Weiser MR, Pechet TT, Williams JP, Ma M, Frenette PS, Moore FD, Kobzik L, Hines RO, Wagner DD, Carroll MC, Hechtman HB. Experimental murine acid aspiration injury is mediated by neutrophils and the alternative complement pathway. J Appl Physiol. 1997 Oct; 83(4):1090-5.
    View in: PubMed
  134. Cooke KR, Nishinakamura R, Martin TR, Kobzik L, Brewer J, Whitsett JA, Bungard D, Murray R, Ferrara JL. Persistence of pulmonary pathology and abnormal lung function in IL-3/GM-CSF/IL-5 beta c receptor-deficient mice despite correction of alveolar proteinosis after BMT. Bone Marrow Transplant. 1997 Oct; 20(8):657-62.
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  135. De Sanctis GT, Mehta S, Kobzik L, Yandava C, Jiao A, Huang PL, Drazen JM. Contribution of type I NOS to expired gas NO and bronchial responsiveness in mice. Am J Physiol. 1997 Oct; 273(4 Pt 1):L883-8.
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  136. Goldsmith CA, Frevert C, Imrich A, Sioutas C, Kobzik L. Alveolar macrophage interaction with air pollution particulates. Environ Health Perspect. 1997 Sep; 105 Suppl 5:1191-5.
    View in: PubMed
  137. Taylor MF, Paulauskis JD, Weller DD, Kobzik L. Comparison of efficacy of antisense oligomers directed toward TNF-alpha in helper T and macrophage cell lines. Cytokine. 1997 Sep; 9(9):672-81.
    View in: PubMed
  138. Imrich A, Kobzik L. Fluorescence-based measurement of nitric oxide synthase activity in activated rat macrophages using dichlorofluorescin. Nitric Oxide. 1997 Aug; 1(4):359-69.
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  139. Haver K, Gerard C, Kobzik L, Shore SA. Neutral endopeptidase activity in newborn and adult rabbit tracheas. Eur Respir J. 1997 Aug; 10(8):1844-9.
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  140. Adler H, Beland JL, Del-Pan NC, Kobzik L, Brewer JP, Martin TR, Rimm IJ. Suppression of herpes simplex virus type 1 (HSV-1)-induced pneumonia in mice by inhibition of inducible nitric oxide synthase (iNOS, NOS2). J Exp Med. 1997 May 5; 185(9):1533-40.
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  141. Kaye DM, Wiviott SD, Kobzik L, Kelly RA, Smith TW. S-nitrosothiols inhibit neuronal norepinephrine transport. Am J Physiol. 1997 Feb; 272(2 Pt 2):H875-83.
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  142. Krinzman SJ, De Sanctis GT, Cernadas M, Mark D, Wang Y, Listman J, Kobzik L, Donovan C, Nassr K, Katona I, Christiani DC, Perkins DL, Finn PW. Inhibition of T cell costimulation abrogates airway hyperresponsiveness in a murine model. J Clin Invest. 1996 Dec 15; 98(12):2693-9.
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  143. Cooke KR, Kobzik L, Martin TR, Brewer J, Delmonte J, Crawford JM, Ferrara JL. An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin. Blood. 1996 Oct 15; 88(8):3230-9.
    View in: PubMed
  144. Simon DI, Rao NK, Xu H, Wei Y, Majdic O, Ronne E, Kobzik L, Chapman HA. Mac-1 (CD11b/CD18) and the urokinase receptor (CD87) form a functional unit on monocytic cells. Blood. 1996 Oct 15; 88(8):3185-94.
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  145. Franke-Ullmann G, Pförtner C, Walter P, Steinmüller C, Lohmann-Matthes ML, Kobzik L. Characterization of murine lung interstitial macrophages in comparison with alveolar macrophages in vitro. J Immunol. 1996 Oct 1; 157(7):3097-104.
    View in: PubMed
  146. Farone AL, Frevert CW, Farone MB, Morin MJ, Fields BN, Paulauskis JD, Kobzik L. Serotype-dependent induction of pulmonary neutrophilia and inflammatory cytokine gene expression by reovirus. J Virol. 1996 Oct; 70(10):7079-84.
    View in: PubMed
  147. Feron O, Belhassen L, Kobzik L, Smith TW, Kelly RA, Michel T. Endothelial nitric oxide synthase targeting to caveolae. Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells. J Biol Chem. 1996 Sep 13; 271(37):22810-4.
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  148. Krinzman SJ, De Sanctis GT, Cernadas M, Kobzik L, Listman JA, Christiani DC, Perkins DL, Finn PW. T cell activation in a murine model of asthma. Am J Physiol. 1996 Sep; 271(3 Pt 1):L476-83.
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  149. Stringer B, Imrich A, Kobzik L. Lung epithelial cell (A549) interaction with unopsonized environmental particulates: quantitation of particle-specific binding and IL-8 production. Exp Lung Res. 1996 Sep-Oct; 22(5):495-508.
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  150. Taylor MF, Paulauskis JD, Weller DD, Kobzik L. In vitro efficacy of morpholino-modified antisense oligomers directed against tumor necrosis factor-alpha mRNA. J Biol Chem. 1996 Jul 19; 271(29):17445-52.
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  151. Gibbs SA, Weiser MR, Kobzik L, Valeri CR, Shepro D, Hechtman HB. P-selectin mediates intestinal ischemic injury by enhancing complement deposition. Surgery. 1996 Jun; 119(6):652-6.
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  152. Han X, Kobzik L, Balligand JL, Kelly RA, Smith TW. Nitric oxide synthase (NOS3)-mediated cholinergic modulation of Ca2+ current in adult rabbit atrioventricular nodal cells. Circ Res. 1996 Jun; 78(6):998-1008.
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  153. Weiser MR, Williams JP, Moore FD, Kobzik L, Ma M, Hechtman HB, Carroll MC. Reperfusion injury of ischemic skeletal muscle is mediated by natural antibody and complement. J Exp Med. 1996 May 1; 183(5):2343-8.
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  154. Massaro AF, Mehta S, Lilly CM, Kobzik L, Reilly JJ, Drazen JM. Elevated nitric oxide concentrations in isolated lower airway gas of asthmatic subjects. Am J Respir Crit Care Med. 1996 May; 153(5):1510-4.
    View in: PubMed
  155. Hashimoto S, Pittet JF, Hong K, Folkesson H, Bagby G, Kobzik L, Frevert C, Watanabe K, Tsurufuji S, Wiener-Kronish J. Depletion of alveolar macrophages decreases neutrophil chemotaxis to Pseudomonas airspace infections. Am J Physiol. 1996 May; 270(5 Pt 1):L819-28.
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  156. Stringer B, Kobzik L. Alveolar macrophage uptake of the environmental particulate titanium dioxide: role of surfactant components. Am J Respir Cell Mol Biol. 1996 Feb; 14(2):155-60.
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  157. Anderson IC, Sugarbaker DJ, Ganju RK, Tsarwhas DG, Richards WG, Sunday M, Kobzik L, Shipp MA. Stromelysin-3 is overexpressed by stromal elements in primary non-small cell lung cancers and regulated by retinoic acid in pulmonary fibroblasts. Cancer Res. 1995 Sep 15; 55(18):4120-6.
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  158. Ungureanu-Longrois D, Balligand JL, Simmons WW, Okada I, Kobzik L, Lowenstein CJ, Kunkel SL, Michel T, Kelly RA, Smith TW. Induction of nitric oxide synthase activity by cytokines in ventricular myocytes is necessary but not sufficient to decrease contractile responsiveness to beta-adrenergic agonists. Circ Res. 1995 Sep; 77(3):494-502.
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  159. Ungureanu-Longrois D, Balligand JL, Okada I, Simmons WW, Kobzik L, Lowenstein CJ, Kunkel SL, Michel T, Kelly RA, Smith TW. Contractile responsiveness of ventricular myocytes to isoproterenol is regulated by induction of nitric oxide synthase activity in cardiac microvascular endothelial cells in heterotypic primary culture. Circ Res. 1995 Sep; 77(3):486-93.
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  160. Mizgerd JP, Kobzik L, Warner AE, Brain JD. Effects of sodium concentration on human neutrophil bactericidal functions. Am J Physiol. 1995 Sep; 269(3 Pt 1):L388-93.
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  161. Kobzik L. Lung macrophage uptake of unopsonized environmental particulates. Role of scavenger-type receptors. J Immunol. 1995 Jul 1; 155(1):367-76.
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  162. Richards WG, Stamler JS, Kobzik L, Sugarbaker DJ. Role of nitric oxide in human esophageal circular smooth muscle in vitro. J Thorac Cardiovasc Surg. 1995 Jul; 110(1):157-64.
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  163. Balligand JL, Kobzik L, Han X, Kaye DM, Belhassen L, O'Hara DS, Kelly RA, Smith TW, Michel T. Nitric oxide-dependent parasympathetic signaling is due to activation of constitutive endothelial (type III) nitric oxide synthase in cardiac myocytes. J Biol Chem. 1995 Jun 16; 270(24):14582-6.
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  164. Kobzik L, Stringer B, Balligand JL, Reid MB, Stamler JS. Endothelial type nitric oxide synthase in skeletal muscle fibers: mitochondrial relationships. Biochem Biophys Res Commun. 1995 Jun 15; 211(2):375-81.
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  165. Shore S, Kobzik L, Long NC, Skornik W, Van Staden CJ, Boulet L, Rodger IW, Pon DJ. Increased airway responsiveness to inhaled methacholine in a rat model of chronic bronchitis. Am J Respir Crit Care Med. 1995 Jun; 151(6):1931-8.
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  166. Stringer B, Imrich A, Kobzik L. Flow cytometric assay of lung macrophage uptake of environmental particulates. Cytometry. 1995 May 1; 20(1):23-32.
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  167. Abdi K, Kobzik L, Li X, Mentzer SJ. Expression of membrane glycoconjugates on sheep lung endothelium. Lab Invest. 1995 Apr; 72(4):445-52.
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  168. Lilly CM, Hall AE, Rodger IW, Kobzik L, Haley KJ, Drazen JM. Substance P-induced histamine release in tracheally perfused guinea pig lungs. J Appl Physiol. 1995 Apr; 78(4):1234-41.
    View in: PubMed
  169. Balligand JL, Ungureanu-Longrois D, Simmons WW, Kobzik L, Lowenstein CJ, Lamas S, Kelly RA, Smith TW, Michel T. Induction of NO synthase in rat cardiac microvascular endothelial cells by IL-1 beta and IFN-gamma. Am J Physiol. 1995 Mar; 268(3 Pt 2):H1293-303.
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  170. Farone A, Huang S, Paulauskis J, Kobzik L. Airway neutrophilia and chemokine mRNA expression in sulfur dioxide-induced bronchitis. Am J Respir Cell Mol Biol. 1995 Mar; 12(3):345-50.
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  171. Shapiro GI, Edwards CD, Kobzik L, Godleski J, Richards W, Sugarbaker DJ, Rollins BJ. Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines. Cancer Res. 1995 Feb 1; 55(3):505-9.
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  172. Frevert CW, Farone A, Danaee H, Paulauskis JD, Kobzik L. Functional characterization of rat chemokine macrophage inflammatory protein-2. Inflammation. 1995 Feb; 19(1):133-42.
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  173. Frevert CW, Huang S, Danaee H, Paulauskis JD, Kobzik L. Functional characterization of the rat chemokine KC and its importance in neutrophil recruitment in a rat model of pulmonary inflammation. J Immunol. 1995 Jan 1; 154(1):335-44.
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  174. Franke-Ullmann G, Pförtner C, Walter P, Steinmüller C, Lohmann-Matthes ML, Kobzik L, Freihorst J. Alteration of pulmonary macrophage function by respiratory syncytial virus infection in vitro. J Immunol. 1995 Jan 1; 154(1):268-80.
    View in: PubMed
  175. Goldman G, Welbourn R, Kobzik L, Valeri CR, Shepro D, Hechtman HB. Neutrophil adhesion receptor CD18 mediates remote but not localized acid aspiration injury. Surgery. 1995 Jan; 117(1):83-9.
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  176. Kobzik L, Reid MB, Bredt DS, Stamler JS. Nitric oxide in skeletal muscle. Nature. 1994 Dec 8; 372(6506):546-8.
    View in: PubMed
  177. Frevert CW, Warner AE, Kobzik L. Defective pulmonary recruitment of neutrophils in a rat model of endotoxemia. Am J Respir Cell Mol Biol. 1994 Dec; 11(6):716-23.
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  178. Slivka A, Chuttani R, Carr-Locke DL, Kobzik L, Bredt DS, Loscalzo J, Stamler JS. Inhibition of sphincter of Oddi function by the nitric oxide carrier S-nitroso-N-acetylcysteine in rabbits and humans. J Clin Invest. 1994 Nov; 94(5):1792-8.
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  179. Abdi K, Kobzik L, Li X, Mentzer SJ. Membrane glycoconjugates expressed on sheep airway epithelium. J Histochem Cytochem. 1994 Oct; 42(10):1341-7.
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  180. Lilly CM, Kobzik L, Hall AE, Drazen JM. Effects of chronic airway inflammation on the activity and enzymatic inactivation of neuropeptides in guinea pig lungs. J Clin Invest. 1994 Jun; 93(6):2667-74.
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  181. Kobzik L, Bredt DS, Lowenstein CJ, Drazen J, Gaston B, Sugarbaker D, Stamler JS. Nitric oxide synthase in human and rat lung: immunocytochemical and histochemical localization. Am J Respir Cell Mol Biol. 1993 Oct; 9(4):371-7.
    View in: PubMed
  182. Simpson R, Alon R, Kobzik L, Valeri CR, Shepro D, Hechtman HB. Neutrophil and nonneutrophil-mediated injury in intestinal ischemia-reperfusion. Ann Surg. 1993 Oct; 218(4):444-53; discussion 453-4.
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  183. Kobzik L, Huang S, Paulauskis JD, Godleski JJ. Particle opsonization and lung macrophage cytokine response. In vitro and in vivo analysis. J Immunol. 1993 Sep 1; 151(5):2753-9.
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  184. Wieder KJ, Hancock WW, Schmidbauer G, Corpier CL, Wieder I, Kobzik L, Strom TB, Kupiec-Weglinski JW. Rapamycin treatment depresses intragraft expression of KC/MIP-2, granzyme B, and IFN-gamma in rat recipients of cardiac allografts. J Immunol. 1993 Jul 15; 151(2):1158-66.
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  185. Goldman G, Welbourn R, Klausner JM, Kobzik L, Valeri CR, Shepro D, Hechtman HB. Leukocytes mediate acid aspiration-induced multiorgan edema. Surgery. 1993 Jul; 114(1):13-20.
    View in: PubMed
  186. Balligand JL, Ungureanu D, Kelly RA, Kobzik L, Pimental D, Michel T, Smith TW. Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium. J Clin Invest. 1993 May; 91(5):2314-9.
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  187. Goldman G, Welbourn R, Kobzik L, Valeri CR, Shepro D, Hechtman HB. Lavage with leukotriene B4 induces lung generation of tumor necrosis factor-alpha that in turn mediates neutrophil diapedesis. Surgery. 1993 Mar; 113(3):297-303.
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  188. Reid MB, Haack KE, Franchek KM, Valberg PA, Kobzik L, West MS. Reactive oxygen in skeletal muscle. I. Intracellular oxidant kinetics and fatigue in vitro. J Appl Physiol. 1992 Nov; 73(5):1797-804.
    View in: PubMed
  189. Rose RM, Kobzik L, Dushay K, Wolfthal S, Hondalus M, Metzger M, Stoudemire J, Brain JD, Garnick M, O'Donnell C, et al. The effect of aerosolized recombinant human granulocyte macrophage colony-stimulating factor on lung leukocytes in nonhuman primates. Am Rev Respir Dis. 1992 Nov; 146(5 Pt 1):1279-86.
    View in: PubMed
  190. Huang S, Paulauskis JD, Godleski JJ, Kobzik L. Expression of macrophage inflammatory protein-2 and KC mRNA in pulmonary inflammation. Am J Pathol. 1992 Oct; 141(4):981-8.
    View in: PubMed
  191. Goldman G, Welbourn R, Klausner JM, Kobzik L, Valeri CR, Shepro D, Hechtman HB. Mast cells and leukotrienes mediate neutrophil sequestration and lung edema after remote ischemia in rodents. Surgery. 1992 Sep; 112(3):578-86.
    View in: PubMed
  192. Goldman G, Welbourn R, Rothlein R, Wiles M, Kobzik L, Valeri CR, Shepro D, Hechtman HB. Adherent neutrophils mediate permeability after atelectasis. Ann Surg. 1992 Sep; 216(3):372-8; discussion 378-80.
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  193. Goldman G, Welbourn R, Kobzik L, Valeri CR, Shepro D, Hechtman HB. Reactive oxygen species and elastase mediate lung permeability after acid aspiration. J Appl Physiol. 1992 Aug; 73(2):571-5.
    View in: PubMed
  194. Welbourn R, Goldman G, Kobzik L, Paterson IS, Valeri CR, Shepro D, Hechtman HB. Role of neutrophil adherence receptors (CD 18) in lung permeability following lower torso ischemia. Circ Res. 1992 Jul; 71(1):82-6.
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  195. Huang S, Paulauskis JD, Kobzik L. Rat KC cDNA cloning and mRNA expression in lung macrophages and fibroblasts. Biochem Biophys Res Commun. 1992 Apr 30; 184(2):922-9.
    View in: PubMed
  196. Rose RM, Kobzik L, Filderman AE, Vermeulen MW, Dushay K, Donahue RE. Characterization of colony stimulating factor activity in the human respiratory tract. Comparison of healthy smokers and nonsmokers. Am Rev Respir Dis. 1992 Feb; 145(2 Pt 1):394-9.
    View in: PubMed
  197. Goldman G, Welbourn R, Kobzik L, Valeri CR, Shepro D, Hechtman HB. Synergism between leukotriene B4 and thromboxane A2 in mediating acid-aspiration injury. Surgery. 1992 Jan; 111(1):55-61.
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  198. Welbourn R, Goldman G, Kobzik L, Paterson I, Shepro D, Hechtman HB. Interleukin-2 induces early multisystem organ edema mediated by neutrophils. Ann Surg. 1991 Aug; 214(2):181-6.
    View in: PubMed
  199. Welbourn R, Goldman G, O'Riordain M, Lindsay TF, Paterson IS, Kobzik L, Valeri CR, Shepro D, Hechtman HB. Role for tumor necrosis factor as mediator of lung injury following lower torso ischemia. J Appl Physiol. 1991 Jun; 70(6):2645-9.
    View in: PubMed
  200. Goldman G, Welbourn R, Klausner JM, Kobzik L, Valeri CR, Shepro D, Hechtman HB. Neutrophil accumulations due to pulmonary thromboxane synthesis mediate acid aspiration injury. J Appl Physiol. 1991 Apr; 70(4):1511-7.
    View in: PubMed
  201. Welbourn R, Goldman G, Kobzik L, Valeri CR, Hechtman HB, Shepro D. Attenuation of IL-2-induced multisystem organ edema by phalloidin and antamanide. J Appl Physiol. 1991 Mar; 70(3):1364-8.
    View in: PubMed
  202. Klausner JM, Paterson IS, Goldman G, Kobzik L, Lelcuk S, Skornick Y, Eberlein T, Valeri CR, Shepro D, Hechtman HB. Interleukin-2-induced lung injury is mediated by oxygen free radicals. Surgery. 1991 Feb; 109(2):169-75.
    View in: PubMed
  203. Goldman G, Welbourn R, Klausner JM, Kobzik L, Valeri CR, Shepro D, Hechtman HB. Intravascular chemoattractants inhibit diapedesis by selective receptor occupancy. Am J Physiol. 1991 Feb; 260(2 Pt 2):H465-72.
    View in: PubMed
  204. Welbourn R, Goldman G, Kobzik L, Valeri CR, Shepro D, Hechtman HB. Involvement of thromboxane and neutrophils in multiple-system organ edema with interleukin-2. Ann Surg. 1990 Dec; 212(6):728-33.
    View in: PubMed
  205. Goldman G, Welbourn R, Klausner JM, Alexander S, Kobzik L, Valeri CR, Shepro D, Hechtman HB. Attenuation of acid aspiration edema with phalloidin. Am J Physiol. 1990 Dec; 259(6 Pt 1):L378-83.
    View in: PubMed
  206. Goldman G, Welbourn R, Kobzik L, Valeri CR, Shepro D, Hechtman HB. Tumor necrosis factor-alpha mediates acid aspiration-induced systemic organ injury. Ann Surg. 1990 Oct; 212(4):513-9; discussion 519-20.
    View in: PubMed
  207. Welbourn R, Goldman G, Kobzik L, Paterson I, Valeri CR, Shepro D, Hechtman HB. Neutrophil adherence receptors (CD 18) in ischemia. Dissociation between quantitative cell surface expression and diapedesis mediated by leukotriene B4. J Immunol. 1990 Sep 15; 145(6):1906-11.
    View in: PubMed
  208. Kobzik L, Godleski JJ, Brain JD. Selective down-regulation of alveolar macrophage oxidative response to opsonin-independent phagocytosis. J Immunol. 1990 Jun 1; 144(11):4312-9.
    View in: PubMed
  209. Kobzik L. Benign pulmonary lesions that may be misdiagnosed as malignant. Semin Diagn Pathol. 1990 May; 7(2):129-38.
    View in: PubMed
  210. Kobzik L, Godleski JJ, Brain JD. Oxidative metabolism in the alveolar macrophage: analysis by flow cytometry. J Leukoc Biol. 1990 Apr; 47(4):295-303.
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  211. Goldman G, Welbourn R, Paterson IS, Klausner JM, Kobzik L, Valeri CR, Shepro D, Hechtman HB. Ischemia-induced neutrophil activation and diapedesis is lipoxygenase dependent. Surgery. 1990 Apr; 107(4):428-33.
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  212. Goldman G, Welbourn R, Klausner JM, Paterson IS, Kobzik L, Valeri CR, Shepro D, Hechtman HB. Ischemia activates neutrophils but inhibits their local and remote diapedesis. Ann Surg. 1990 Feb; 211(2):196-201.
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  213. Paterson IS, Klausner JM, Goldman G, Kobzik L, Welbourn R, Valeri CR, Shepro D, Hechtman HB. Thromboxane mediates the ischemia-induced neutrophil oxidative burst. Surgery. 1989 Aug; 106(2):224-9.
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  214. Klausner JM, Paterson IS, Goldman G, Kobzik L, Valeri CR, Shepro D, Hechtman HB. Thromboxane A2 mediates increased pulmonary microvascular permeability following limb ischemia. Circ Res. 1989 Jun; 64(6):1178-89.
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  215. Klausner JM, Paterson IS, Goldman G, Kobzik L, Rodzen C, Lawrence R, Valeri CR, Shepro D, Hechtman HB. Postischemic renal injury is mediated by neutrophils and leukotrienes. Am J Physiol. 1989 May; 256(5 Pt 2):F794-802.
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  216. Klausner JM, Paterson IS, Kobzik L, Valeri CR, Shepro D, Hechtman HB. Leukotrienes but not complement mediate limb ischemia-induced lung injury. Ann Surg. 1989 Apr; 209(4):462-70.
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  217. Sorokin SP, Kobzik L, Hoyt RF, Godleski JJ. Development of surface membrane characteristics of "premedullary" macrophages in organ cultures of embryonic rat and hamster lungs. J Histochem Cytochem. 1989 Mar; 37(3):365-76.
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  218. Klausner JM, Paterson IS, Kobzik L, Valeri CR, Shepro D, Hechtman HB. Oxygen free radicals mediate ischemia-induced lung injury. Surgery. 1989 Feb; 105(2 Pt 1):192-9.
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  219. Klausner JM, Paterson IS, Kobzik L, Rodzen C, Valeri CR, Shepro D, Hechtman HB. Vasodilating prostaglandins attenuate ischemic renal injury only if thromboxane is inhibited. Ann Surg. 1989 Feb; 209(2):219-24.
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  220. Klausner JM, Morel N, Paterson IS, Kobzik L, Valeri CR, Eberlein TJ, Shepro D, Hechtman HB. The rapid induction by interleukin-2 of pulmonary microvascular permeability. Ann Surg. 1989 Jan; 209(1):119-28.
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  221. Klausner JM, Anner H, Paterson IS, Kobzik L, Valeri CR, Shepro D, Hechtman HB. Lower torso ischemia-induced lung injury is leukocyte dependent. Ann Surg. 1988 Dec; 208(6):761-7.
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  222. Kobzik L, Godleski JJ, Barry BE, Brain JD. Isolation and antigenic identification of hamster lung interstitial macrophages. Am Rev Respir Dis. 1988 Oct; 138(4):908-14.
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  223. Klausner JM, Kobzik L, Valeri CR, Shepro D, Hechtman HB. Selective lung leukosequestration after complement activation. J Appl Physiol. 1988 Jul; 65(1):80-8.
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  224. Hancock WW, Pleau ME, Kobzik L. Recombinant granulocyte-macrophage colony-stimulating factor down-regulates expression of IL-2 receptor on human mononuclear phagocytes by induction of prostaglandin E. J Immunol. 1988 May 1; 140(9):3021-5.
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  225. Kaufman RP, Klausner JM, Anner H, Feingold H, Kobzik L, Valeri CR, Shepro D, Hechtman HB. Inhibition of thromboxane (Tx) synthesis by free radical scavengers. J Trauma. 1988 Apr; 28(4):458-64.
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  226. Chapman HA, Reilly JJ, Kobzik L. Role of plasminogen activator in degradation of extracellular matrix protein by live human alveolar macrophages. Am Rev Respir Dis. 1988 Feb; 137(2):412-9.
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  227. Kaufman RP, Anner H, Kobzik L, Valeri CR, Shepro D, Hechtman HB. A high plasma prostaglandin to thromboxane ratio protects against renal ischemia. Surg Gynecol Obstet. 1987 Nov; 165(5):404-9.
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  228. Anner H, Kaufman RP, Kobzik L, Valeri CR, Shepro D, Hechtman HB. Pulmonary hypertension and leukosequestration after lower torso ischemia. Ann Surg. 1987 Nov; 206(5):642-8.
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  229. Anner H, Kaufman RP, Kobzik L, Valeri CR, Shepro D, Hechtman HB. Pulmonary leukosequestration induced by hind limb ischemia. Ann Surg. 1987 Aug; 206(2):162-7.
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  230. Huber DJ, Kobzik L, Solorzano C, Melanson G, Adams DF. Nuclear magnetic resonance spectroscopy of acute and evolving pulmonary hemorrhage. An in vitro study. Invest Radiol. 1987 Aug; 22(8):632-7.
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  231. Kaufman RP, Anner H, Kobzik L, Valeri CR, Shepro D, Hechtman HB. Vasodilator prostaglandins (PG) prevent renal damage after ischemia. Ann Surg. 1987 Feb; 205(2):195-8.
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  232. Hancock WW, Kobzik L, Colby AJ, O'Hara CJ, Cooper AG, Godleski JJ. Detection of lymphokines and lymphokine receptors in pulmonary sarcoidosis. Immunohistologic evidence that inflammatory macrophages express IL-2 receptors. Am J Pathol. 1986 Apr; 123(1):1-8.
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  233. Manny J, Manny N, Lelcuk S, Alexander F, Feingold H, Kobzik L, Valeri CR, Shepro D, Hechtman HB. Pulmonary and systemic consequences of localized acid aspiration. Surg Gynecol Obstet. 1986 Mar; 162(3):259-67.
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  234. Kobzik L, Godleski JJ, Biondi A, O'Hara CJ, Todd RF. Immunohistologic analysis of a human pulmonary alveolar macrophage antigen. Clin Immunol Immunopathol. 1985 Nov; 37(2):213-9.
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  235. Kobzik L, Godleski JJ, Brain JD. Ultrastructural analysis of a specific hamster alveolar macrophage antigen. Lab Invest. 1985 Nov; 53(5):526-33.
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  236. Lelcuk S, Alexander F, Kobzik L, Valeri CR, Shepro D, Hechtman HB. Prostacyclin and thromboxane A2 moderate postischemic renal failure. Surgery. 1985 Aug; 98(2):207-12.
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  237. Huber DJ, Kobzik L, Melanson G, Adams DF. The detection of inflammation in collapsed lung by alterations in proton nuclear magnetic relaxation times. Invest Radiol. 1985 Aug; 20(5):460-4.
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  238. Kobzik L, Antman KH, Warhol MJ. The distinction of mesothelioma from adenocarcinoma in malignant effusions by electron microscopy. Acta Cytol. 1985 May-Jun; 29(3):219-25.
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  239. Godleski JJ, Mortara M, Joher MA, Kobzik L, Brain JD. Monoclonal antibody to an alveolar macrophage surface antigen in hamsters. Am Rev Respir Dis. 1984 Aug; 130(2):249-55.
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  240. Kobzik L, Brown MC, Cooper AG. Demonstration of an idiotypic antigen on a monoclonal cold agglutinin and on its isolated heavy and light chains. Proc Natl Acad Sci U S A. 1976 May; 73(5):1702-6.
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