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Last Name
Institution

Richard Bouley, PH.D.

TitleInstructor in Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
Simches Research Center, Division of Nephrology
185 Cambridge St
Boston MA 02114
Phone617/726-1375
Fax617/643-3182

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Nunes P, Ernandez T, Roth I, Qiao X, Strebel D, Bouley R, Charollais A, Ramadori P, Foti M, Meda P, Féraille E, Brown D, Hasler U. Hypertonic stress promotes autophagy and microtubule-dependent autophagosomal clusters. Autophagy. 2013 Apr 1; 9(4):550-67.
    View in: PubMed
  2. Bouley R, Nunes P, Andriopoulos B, McLaughlin M, Webber MJ, Lin HY, Babitt JL, Gardella TJ, Ausiello DA, Brown D. Heterologous downregulation of vasopressin type 2 receptor is induced by transferrin. Am J Physiol Renal Physiol. 2013 Mar; 304(5):F553-64.
    View in: PubMed
  3. Yui N, Lu HA, Chen Y, Nomura N, Bouley R, Brown D. Basolateral targeting and microtubule-dependent transcytosis of the aquaporin-2 water channel. Am J Physiol Cell Physiol. 2013 Jan; 304(1):C38-48.
    View in: PubMed
  4. Bouley R. Corin: a key protein of an adaptive renal mechanism to respond to salt variation? Kidney Int. 2012 Jul; 82(1):7-8.
    View in: PubMed
  5. Brown D, Bouley R, Paunescu TG, Breton S, Lu HA. New insights into the dynamic regulation of water and acid-base balance by renal epithelial cells. Am J Physiol Cell Physiol. 2012 May 15; 302(10):C1421-33.
    View in: PubMed
  6. Yui N, Lu HJ, Bouley R, Brown D. AQP2 is necessary for vasopressin- and forskolin-mediated filamentous actin depolymerization in renal epithelial cells. Biol Open. 2012 Feb 15; 1(2):101-8.
    View in: PubMed
  7. Chen S, Webber MJ, Vilardaga JP, Khatri A, Brown D, Ausiello DA, Lin HY, Bouley R. Visualizing microtubule-dependent vasopressin type 2 receptor trafficking using a new high-affinity fluorescent vasopressin ligand. Endocrinology. 2011 Oct; 152(10):3893-904.
    View in: PubMed
  8. Li W, Zhang Y, Bouley R, Chen Y, Matsuzaki T, Nunes P, Hasler U, Brown D, Lu HA. Simvastatin enhances aquaporin-2 surface expression and urinary concentration in vasopressin-deficient Brattleboro rats through modulation of Rho GTPase. Am J Physiol Renal Physiol. 2011 Aug; 301(2):F309-18.
    View in: PubMed
  9. Bouley R, Lu HA, Nunes P, Da Silva N, McLaughlin M, Chen Y, Brown D. Calcitonin has a vasopressin-like effect on aquaporin-2 trafficking and urinary concentration. J Am Soc Nephrol. 2011 Jan; 22(1):59-72.
    View in: PubMed
  10. Xia Y, Babitt JL, Bouley R, Zhang Y, Da Silva N, Chen S, Zhuang Z, Samad TA, Brenner GJ, Anderson JL, Hong CC, Schneyer AL, Brown D, Lin HY. Dragon enhances BMP signaling and increases transepithelial resistance in kidney epithelial cells. J Am Soc Nephrol. 2010 Apr; 21(4):666-77.
    View in: PubMed
  11. Bouley R, Palomino Z, Tang SS, Nunes P, Kobori H, Lu HA, Shum WW, Sabolic I, Brown D, Ingelfinger JR, Jung FF. Angiotensin II and hypertonicity modulate proximal tubular aquaporin 1 expression. Am J Physiol Renal Physiol. 2009 Dec; 297(6):F1575-86.
    View in: PubMed
  12. Ferrandon S, Feinstein TN, Castro M, Wang B, Bouley R, Potts JT, Gardella TJ, Vilardaga JP. Sustained cyclic AMP production by parathyroid hormone receptor endocytosis. Nat Chem Biol. 2009 Oct; 5(10):734-42.
    View in: PubMed
  13. Van Hoek AN, Bouley R, Lu Y, Silberstein C, Brown D, Wax MB, Patil RV. Vasopressin-induced differential stimulation of AQP4 splice variants regulates the in-membrane assembly of orthogonal arrays. Am J Physiol Renal Physiol. 2009 Jun; 296(6):F1396-404.
    View in: PubMed
  14. Nunes P, Hasler U, McKee M, Lu HA, Bouley R, Brown D. A fluorimetry-based ssYFP secretion assay to monitor vasopressin-induced exocytosis in LLC-PK1 cells expressing aquaporin-2. Am J Physiol Cell Physiol. 2008 Dec; 295(6):C1476-87.
    View in: PubMed
  15. Brown D, Hasler U, Nunes P, Bouley R, Lu HA. Phosphorylation events and the modulation of aquaporin 2 cell surface expression. Curr Opin Nephrol Hypertens. 2008 Sep; 17(5):491-8.
    View in: PubMed
  16. Zalyapin EA, Bouley R, Hasler U, Vilardaga JP, Lin HY, Brown D, Ausiello DA. Effects of the renal medullary pH and ionic environment on vasopressin binding and signaling. Kidney Int. 2008 Dec; 74(12):1557-67.
    View in: PubMed
  17. Hasler U, Leroy V, Jeon US, Bouley R, Dimitrov M, Kim JA, Brown D, Kwon HM, Martin PY, Féraille E. NF-kappaB modulates aquaporin-2 transcription in renal collecting duct principal cells. J Biol Chem. 2008 Oct 17; 283(42):28095-105.
    View in: PubMed
  18. Hasler U, Nunes P, Bouley R, Lu HA, Matsuzaki T, Brown D. Acute hypertonicity alters aquaporin-2 trafficking and induces a MAPK-dependent accumulation at the plasma membrane of renal epithelial cells. J Biol Chem. 2008 Sep 26; 283(39):26643-61.
    View in: PubMed
  19. Bouley R, Hasler U, Lu HA, Nunes P, Brown D. Bypassing vasopressin receptor signaling pathways in nephrogenic diabetes insipidus. Semin Nephrol. 2008 May; 28(3):266-78.
    View in: PubMed
  20. Lu HJ, Matsuzaki T, Bouley R, Hasler U, Qin QH, Brown D. The phosphorylation state of serine 256 is dominant over that of serine 261 in the regulation of AQP2 trafficking in renal epithelial cells. Am J Physiol Renal Physiol. 2008 Jul; 295(1):F290-4.
    View in: PubMed
  21. Lu HA, Sun TX, Matsuzaki T, Yi XH, Eswara J, Bouley R, McKee M, Brown D. Heat shock protein 70 interacts with aquaporin-2 and regulates its trafficking. J Biol Chem. 2007 Sep 28; 282(39):28721-32.
    View in: PubMed
  22. Yi X, Bouley R, Lin HY, Bechoua S, Sun TX, Del Re E, Shioda T, Raychowdhury MK, Lu HA, Abou-Samra AB, Brown D, Ausiello DA. Alix (AIP1) is a vasopressin receptor (V2R)-interacting protein that increases lysosomal degradation of the V2R. Am J Physiol Renal Physiol. 2007 May; 292(5):F1303-13.
    View in: PubMed
  23. Sever S, Skoch J, Newmyer S, Ramachandran R, Ko D, McKee M, Bouley R, Ausiello D, Hyman BT, Bacskai BJ. Physical and functional connection between auxilin and dynamin during endocytosis. EMBO J. 2006 Sep 20; 25(18):4163-74.
    View in: PubMed
  24. Bouley R, Hawthorn G, Russo LM, Lin HY, Ausiello DA, Brown D. Aquaporin 2 (AQP2) and vasopressin type 2 receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in 'endocytosis-resistant' membrane domains after vasopressin treatment. Biol Cell. 2006 Apr; 98(4):215-32.
    View in: PubMed
  25. Raychowdhury MK, McLaughlin M, Ramos AJ, Montalbetti N, Bouley R, Ausiello DA, Cantiello HF. Characterization of single channel currents from primary cilia of renal epithelial cells. J Biol Chem. 2005 Oct 14; 280(41):34718-22.
    View in: PubMed
  26. Bouley R, Lin HY, Raychowdhury MK, Marshansky V, Brown D, Ausiello DA. Downregulation of the vasopressin type 2 receptor after vasopressin-induced internalization: involvement of a lysosomal degradation pathway. Am J Physiol Cell Physiol. 2005 Jun; 288(6):C1390-401.
    View in: PubMed
  27. Bouley R, Pastor-Soler N, Cohen O, McLaughlin M, Breton S, Brown D. Stimulation of AQP2 membrane insertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra). Am J Physiol Renal Physiol. 2005 Jun; 288(6):F1103-12.
    View in: PubMed
  28. Silberstein C, Bouley R, Huang Y, Fang P, Pastor-Soler N, Brown D, Van Hoek AN. Membrane organization and function of M1 and M23 isoforms of aquaporin-4 in epithelial cells. Am J Physiol Renal Physiol. 2004 Sep; 287(3):F501-11.
    View in: PubMed
  29. Lu H, Sun TX, Bouley R, Blackburn K, McLaughlin M, Brown D. Inhibition of endocytosis causes phosphorylation (S256)-independent plasma membrane accumulation of AQP2. Am J Physiol Renal Physiol. 2004 Feb; 286(2):F233-43.
    View in: PubMed
  30. Bouley R, Sun TX, Chenard M, McLaughlin M, McKee M, Lin HY, Brown D, Ausiello DA. Functional role of the NPxxY motif in internalization of the type 2 vasopressin receptor in LLC-PK1 cells. Am J Physiol Cell Physiol. 2003 Oct; 285(4):C750-62.
    View in: PubMed
  31. van Balkom BW, van Raak M, Breton S, Pastor-Soler N, Bouley R, van der Sluijs P, Brown D, Deen PM. Hypertonicity is involved in redirecting the aquaporin-2 water channel into the basolateral, instead of the apical, plasma membrane of renal epithelial cells. J Biol Chem. 2003 Jan 10; 278(2):1101-7.
    View in: PubMed
  32. Sun TX, Van Hoek A, Huang Y, Bouley R, McLaughlin M, Brown D. Aquaporin-2 localization in clathrin-coated pits: inhibition of endocytosis by dominant-negative dynamin. Am J Physiol Renal Physiol. 2002 Jun; 282(6):F998-1011.
    View in: PubMed
  33. Bouley R, Breton S, Sun T, McLaughlin M, Nsumu NN, Lin HY, Ausiello DA, Brown D. Nitric oxide and atrial natriuretic factor stimulate cGMP-dependent membrane insertion of aquaporin 2 in renal epithelial cells. J Clin Invest. 2000 Nov; 106(9):1115-26.
    View in: PubMed
  34. Pérodin J, Bouley R, Escher E, Assimomytis N, Magafa V, Manessi-Zoupa E, Theodoropoulos D, Cordopatis P. Angiotensin II analogues with sulphur-containing side-chains in position 5. A structure-activity relationship study. Arzneimittelforschung. 2000 Jun; 50(6):526-9.
    View in: PubMed
  35. Stevens AL, Breton S, Gustafson CE, Bouley R, Nelson RD, Kohan DE, Brown D. Aquaporin 2 is a vasopressin-independent, constitutive apical membrane protein in rat vas deferens. Am J Physiol Cell Physiol. 2000 Apr; 278(4):C791-802.
    View in: PubMed
  36. Gustafson CE, Katsura T, McKee M, Bouley R, Casanova JE, Brown D. Recycling of AQP2 occurs through a temperature- and bafilomycin-sensitive trans-Golgi-associated compartment. Am J Physiol Renal Physiol. 2000 Feb; 278(2):F317-26.
    View in: PubMed
  37. Bouley R, Pérodin J, Plante H, Rihakova L, Bernier SG, Maletínská L, Guillemette G, Escher E. N- and C-terminal structure-activity study of angiotensin II on the angiotensin AT2 receptor. Eur J Pharmacol. 1998 Feb 19; 343(2-3):323-31.
    View in: PubMed
  38. Bouley R, Gosselin M, Plante H, Servant G, Pérodin J, Arcand M, Guillemette G, Escher E. Characterization of a specific binding site for angiotensin II in chicken liver. Can J Physiol Pharmacol. 1997 Jun; 75(6):568-75.
    View in: PubMed
  39. Barbeau D, Bouley R, Escher E. Molecular weight determination of the hepatic vasopressin receptor with a high-affinity photoprobe. Int J Pept Protein Res. 1996 Oct; 48(4):364-73.
    View in: PubMed
  40. Pérodin J, Bossé R, Gagnon S, Zhou LM, Bouley R, Leduc R, Escher E. Structure-activity relationship of the agonist-antagonist transition on the type 1 angiotensin II receptor; the search for inverse agonists. Adv Exp Med Biol. 1996; 396:131-43.
    View in: PubMed
  41. Cordopatis P, Manessi-Zoupa E, Theodoropoulos D, Bossé R, Bouley R, Gagnon S, Escher E. Methylation in positions 1 and 7 of angiotensin II. A structure-activity relationship study. Int J Pept Protein Res. 1994 Oct; 44(4):320-4.
    View in: PubMed
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