Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Last Name

Li Chai, M.D.

TitleAssistant Professor of Pathology
InstitutionBrigham and Women's Hospital
AddressBrigham and Women's Hospital
Amory 2-268, Blood Bank
75 Francis St
Boston MA 02115

 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Liang OD, Lu J, Nombela-Arrieta C, Zhong J, Zhao L, Pivarnik G, Mondal S, Chai L, Silberstein LE, Luo HR. Deficiency of Lipid Phosphatase SHIP Enables Long-Term Reconstitution of Hematopoietic Inductive Bone Marrow Microenvironment. Dev Cell. 2013 May 28; 25(4):333-49.
    View in: PubMed
  2. Chai L, Romero D, Kayatekin C, Akabayov B, Vlamakis H, Losick R, Kolter R. Isolation, characterization, and aggregation of a structured bacterial matrix precursor. J Biol Chem. 2013 Jun 14; 288(24):17559-68.
    View in: PubMed
  3. Gao C, Dimitrov T, Yong KJ, Tatetsu H, Jeong HW, Luo HR, Bradner JE, Tenen DG, Chai L. Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex. Blood. 2013 Feb 21; 121(8):1413-21.
    View in: PubMed
  4. Rubinstein SM, Kolodkin-Gal I, McLoon A, Chai L, Kolter R, Losick R, Weitz DA. Osmotic pressure can regulate matrix gene expression in Bacillus subtilis. Mol Microbiol. 2012 Oct; 86(2):426-36.
    View in: PubMed
  5. Gao C, Kong NR, Li A, Tatetu H, Ueno S, Yang Y, He J, Yang J, Ma Y, Kao GS, Tenen DG, Chai L. SALL4 is a key transcription regulator in normal human hematopoiesis. Transfusion. 2013 May; 53(5):1037-49.
    View in: PubMed
  6. Kolodkin-Gal I, Cao S, Chai L, Böttcher T, Kolter R, Clardy J, Losick R. A self-produced trigger for biofilm disassembly that targets exopolysaccharide. Cell. 2012 Apr 27; 149(3):684-92.
    View in: PubMed
  7. Hobbs RM, Fagoonee S, Papa A, Webster K, Altruda F, Nishinakamura R, Chai L, Pandolfi PP. Functional antagonism between Sall4 and Plzf defines germline progenitors. Cell Stem Cell. 2012 Mar 2; 10(3):284-98.
    View in: PubMed
  8. Lu J, Sun Y, Nombela-Arrieta C, Du KP, Park SY, Chai L, Walkley C, Luo HR, Silberstein LE. Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion. Exp Hematol. 2012 Apr; 40(4):307-17.e3.
    View in: PubMed
  9. Chai L. The role of HSAL (SALL) genes in proliferation and differentiation in normal hematopoiesis and leukemogenesis. Transfusion. 2011 Nov; 51 Suppl 4:87S-93S.
    View in: PubMed
  10. Jeong HW, Cui W, Yang Y, Lu J, He J, Li A, Song D, Guo Y, Liu BH, Chai L. SALL4, a stem cell factor, affects the side population by regulation of the ATP-binding cassette drug transport genes. PLoS One. 2011; 6(4):e18372.
    View in: PubMed
  11. Gao C, Kong NR, Chai L. The role of stem cell factor SALL4 in leukemogenesis. Crit Rev Oncog. 2011; 16(1-2):117-27.
    View in: PubMed
  12. Lu J, Jeong HW, Jeong H, Kong N, Yang Y, Carroll J, Luo HR, Silberstein LE, Chai L. Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex. PLoS One. 2009; 4(5):e5577.
    View in: PubMed
  13. Le Y, Xu L, Lu J, Fang J, Nardi V, Chai L, Silberstein LE. FAK silencing inhibits leukemogenesis in BCR/ABL-transformed hematopoietic cells. Am J Hematol. 2009 May; 84(5):273-8.
    View in: PubMed
  14. Jia Y, Loison F, Hattori H, Li Y, Erneux C, Park SY, Gao C, Chai L, Silberstein LE, Schurmans S, Luo HR. Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4739-44.
    View in: PubMed
  15. Cui W, Kong NR, Ma Y, Amin HM, Lai R, Chai L. Differential expression of the novel oncogene, SALL4, in lymphoma, plasma cell myeloma, and acute lymphoblastic leukemia. Mod Pathol. 2006 Dec; 19(12):1585-92.
    View in: PubMed
  16. Zhang, J., Tam, W.L., Tong, G., Wu, Q.,Chan, H. Y., Soh, B.S., Lou, Y., Yang, J., Ma, Y., Chai, L., Ng, H.H., Lufkin, T., Robson, P., Lim, B. . Sall4 modulates embryonic stem cell pluripotency and early embryonic development by transcription regulation of Pou5f1. Nat Cell Bio. 2006; 8(10):1114-23.
  17. Ma Y, Cui W, Yang J, Qu J, Di C, Amin HM, Lai R, Ritz J, Krause DS, Chai L. SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice. Blood. 2006 Oct 15; 108(8):2726-35.
    View in: PubMed
  18. Chai L, Yang J, Di C, Cui W, Kawakami K, Lai R, Ma Y. Transcriptional activation of the SALL1 by the human SIX1 homeodomain during kidney development. J Biol Chem. 2006 Jul 14; 281(28):18918-26.
    View in: PubMed
  19. Chai, L., Cui, W., Yang, JC., Di, C., Amin, H., Ma, Y. . a novel oncogene induces myelodysplastic syndrome and acute myeloid leukemia via Wnt/beta-catenin pathway. Blood/Presentation at ASH. 2005; 106:397a.
  20. Chai, L., Cui, Ritz, J, Krause, DS., Ma, Y. The role of SALL4, a novel oncogene in leukemia stem cell. The HSCT stem cell symposium poster presentation. 2005.
  21. Chai, L, Ma YP. Targeting of SALL4 for the treatment and diagnosis of proliferative disorders associated with myelodysplastic syndrome (MDS). 2005.
  22. Cui, W., Ma, YP., Chai, L. Using Novel Oncogene SALL4 as a Diagnostic Marker for B-cell Acute Lymphoblastic Leukemia (B-ALL). 2nd IABMR (International association for biological and medical research) presentation. 2005.
  23. Chai, L. Krause, DS. Myelopoiesis is impaired in Sall2-null mice. Blood/Presentation at ASH, 2003. 2003; 102:334A.
  24. Herzog EL, Chai L, Krause DS. Plasticity of marrow-derived stem cells. Blood. 2003 Nov 15; 102(10):3483-93.
    View in: PubMed
  25. Chai, L., Sweeney, J. . Interdiction of pre-procedure plasma in patients undergoing invasive procedures. Transfusion/Presentation at AABB, 2002. 2002.
  26. Pomper G, Chai L, Snyder E. Platelet Transfusion and Alternatives. Simon TL, Dzik WH, Snyder EL, Stowell CP, Strauss RG, editors. 2002; p232-47.
  27. Ma Y, Chai L, Cortez SC, Stopa EG, Steinhoff MM, Ford D, Morgan J, Maizel AL. SALL1 expression in the human pituitary-adrenal/gonadal axis. J Endocrinol. 2002 Jun; 173(3):437-48.
    View in: PubMed
  28. Chai, L., Krause, D., Kouttab, N., and Maizel, A.L. Hsal 2, A Novel Homeobox Gene, With Two Alternative Promoters, Is Repressed by WT-1, and Is Differentially Expressed in Myelopoiesis and Leukemogenesis. Blood/Presentation at ASH 2001. 2001.
  29. Pomper, G., Chai, L., Champion, M., Neal, Z., and Snyder, E. . Incidence of Febrile and Allergic Reactions Following Introduction of Prestorage Universal Leukoreduction of Random Donor Platelets and Red Cells. Transfusion/Presentation for AABB 2001. 2001.
  30. Chai, L., Pomper, G., Ross, R., Neal, Z., Champion, M., and Snyder, E. Hemolytic Anemia and Liver Damage Induced by Prophylactic Use of Cefotetan. Transfusion/Presentation at AABB 2001. 2001.
  31. Safran H, Steinhoff M, Mangray S, Rathore R, King TC, Chai L, Berzein K, Moore T, Iannitti D, Reiss P, Pasquariello T, Akerman P, Quirk D, Mass R, Goldstein L, Tantravahi U. Overexpression of the HER-2/neu oncogene in pancreatic adenocarcinoma. Am J Clin Oncol. 2001 Oct; 24(5):496-9.
    View in: PubMed
  32. Ma Y, Li D, Chai L, Luciani AM, Ford D, Morgan J, Maizel AL. Cloning and characterization of two promoters for the human HSAL2 gene and their transcriptional repression by the Wilms tumor suppressor gene product. J Biol Chem. 2001 Dec 21; 276(51):48223-30.
    View in: PubMed
  33. Ma Y, Singer DB, Gozman A, Ford D, Chai L, Steinhoff MM, Hansen K, Maizel AL. Hsal 1 is related to kidney and gonad development and is expressed in Wilms tumor. Pediatr Nephrol. 2001 Sep; 16(9):701-9.
    View in: PubMed
  34. Chai, L. Sweeney, J. . Platelet Transfusion. 2001.
  35. Sweeney J, Chai L. . The Author’s Reply to University Leukoreduction of Cellular Blood Components. Am Clin Patholo. 2001; 116:778-779..
  36. Ma, Y., Chai, L., Steinhoff, M.M., Taylor, W., and Maizel, A.L. . Hsal 2 Is Expressed at Multiple Levels of the Reproductive Axis and Sex Hormone-producing Tumors. Mod. Patho. 2000; (13):73A..
  37. Chai, L., Ma, Y., Kouttab, N., and Maizel, A.L. . Level of Expression of A Novel Homeobox Gene, Hsal 2, Is Related to Cellular Lineage, Maturational Stage and Transformation. Blood. 2000; 96:4256.
  38. Mangray, S., Steinhoff, M.M., Chai, L., Safran, T., and King, T. . Her-2/neu Expression in Pancreatic Adenocarcinoma. Mod. Patho. 2000; (13):187A..
  39. Chai L, Pomper G, Snyder E. . Transfusion Medicine Topic Update: Transfusion Associated Graft-Versus-Host Disease and Irradiation of Blood Components. 2000.
  40. Ma, Y., Gozman, A., Chai, L., Steinhoff, M.M., Hansen, K., and Maizel, A.L. Identification of the Townes-Brocks Syndrome Gene Product and its Involvement of Kidney and Gonad Development. Mod. Patho. 2000; (13):106A.
  41. Chai, L., Hanna, I., Ginepp, D. . The Clear Cell Variant of Acinic cell Carcinoma Does exist: A review of Four Cases. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, & Endodonitics. 2000; 90(4):490.
  42. Cortez, S., Ma, Y., Chai, L., Stopa, E., Maizel, A.L. . Presence of Hsal 1, A Downstream Component of Hedgehog/TGF-beta Signals in Human Pituitary. Journal of Neuropathology and Experimental Neurology,. 2000; 59:452.
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at
Chai's Networks
Click the "See All" links for more information and interactive visualizations!
Similar People
Same Department
Physical Neighbors