Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

George C. Tsokos, M.D.

TitleProfessor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Medical Center
Rheumatology - E/CLS 937
330 Brookline Ave
Boston MA 02215
Phone617/735-4161
Fax617/735-4170

 Mentoring 
 current student opportunities
Available: 09/29/13, Expires: 05/28/15

see http://dms.hms.harvard.edu/immunology/fac/Tsokos.php for complete description of projects. student role can be tailored to match prior experience and available time.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Thai TH, Patterson HC, Pham DH, Kis-Toth K, Kaminski DA, Tsokos GC. Deletion of microRNA-155 reduces autoantibody responses and alleviates lupus-like disease in the Faslpr mouse. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20194-9.
    View in: PubMed
  2. Hedrich CM, Rauen T, Crispin JC, Koga T, Ioannidis C, Zajdel M, Kyttaris VC, Tsokos GC. cAMP-responsive Element Modulator a (CREMa) trans-Represses the Transmembrane Glycoprotein CD8 and Contributes to the Generation of CD3+CD4-CD8- T Cells in Health and Disease. J Biol Chem. 2013 Nov 1; 288(44):31880-7.
    View in: PubMed
  3. Grammatikos AP, Ghosh D, Devlin A, Kyttaris VC, Tsokos GC. Spleen Tyrosine Kinase (Syk) Regulates Systemic Lupus Erythematosus (SLE) T Cell Signaling. PLoS One. 2013; 8(8):e74550.
    View in: PubMed
  4. Deng GM, Beltran J, Chen C, Terhorst C, Tsokos GC. T Cell CD3? Deficiency Enables Multiorgan Tissue Inflammation. J Immunol. 2013 Oct 1; 191(7):3563-7.
    View in: PubMed
  5. Kannan L, Kis-Toth K, Yoshiya K, Thai TH, Sehrawat S, Mayadas TN, Dalle Lucca JJ, Tsokos GC. R-spondin3 prevents mesenteric ischemia/reperfusion-induced tissue damage by tightening endothelium and preventing vascular leakage. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):14348-53.
    View in: PubMed
  6. Apostolidis SA, Rauen T, Hedrich CM, Tsokos GC, Crispín JC. Protein Phosphatase 2A Enables Expression of Interleukin 17 (IL-17) through Chromatin Remodeling. J Biol Chem. 2013 Sep 13; 288(37):26775-84.
    View in: PubMed
  7. Davis TE, Kis-Toth K, Szanto A, Tsokos GC. Glucocorticoids Suppress T Cell Function by Up-Regulating MicroRNA-98. Arthritis Rheum. 2013 Jul; 65(7):1882-90.
    View in: PubMed
  8. Sunahori K, Nagpal K, Hedrich CM, Mizui M, Fitzgerald LM, Tsokos GC. The Catalytic Subunit of Protein Phosphatase 2A (PP2Ac) Promotes DNA Hypomethylation by Suppressing the Phosphorylated Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase (ERK) Kinase (MEK)/Phosphorylated ERK/DNMT1 Protein Pathway in T-cells from Controls and Systemic Lupus Erythematosus Patients. J Biol Chem. 2013 Jul 26; 288(30):21936-44.
    View in: PubMed
  9. Kyttaris VC, Kampagianni O, Tsokos GC. Treatment with anti-interleukin 23 antibody ameliorates disease in lupus-prone mice. Biomed Res Int. 2013; 2013:861028.
    View in: PubMed
  10. Crispín JC, Hedrich CM, Tsokos GC. Gene-function studies in systemic lupus erythematosus. Nat Rev Rheumatol. 2013 Aug; 9(8):476-84.
    View in: PubMed
  11. Paz Z, Tsokos GC. New therapeutics in systemic lupus erythematosus. Curr Opin Rheumatol. 2013 May; 25(3):297-303.
    View in: PubMed
  12. Keszei M, Detre C, Castro W, Magelky E, O'Keeffe M, Kis-Toth K, Tsokos GC, Wang N, Terhorst C. Expansion of an osteopontin-expressing T follicular helper cell subset correlates with autoimmunity in B6.Sle1b mice and is suppressed by the H1-isoform of the Slamf6 receptor. FASEB J. 2013 Aug; 27(8):3123-31.
    View in: PubMed
  13. Hedrich CM, Tsokos GC. Bridging the gap between autoinflammation and autoimmunity. Clin Immunol. 2013 Jun; 147(3):151-4.
    View in: PubMed
  14. Rauen T, Hedrich CM, Tenbrock K, Tsokos GC. cAMP responsive element modulator: a critical regulator of cytokine production. Trends Mol Med. 2013 Apr; 19(4):262-9.
    View in: PubMed
  15. Ichinose K, Zhang Z, Koga T, Juang YT, Kis-Tóth K, Sharpe AH, Kuchroo V, Crispín JC, Tsokos GC. Brief Report: Increased expression of a short splice variant of CTLA-4 exacerbates lupus in MRL/lpr mice. Arthritis Rheum. 2013 Mar; 65(3):764-9.
    View in: PubMed
  16. Ogembo JG, Kannan L, Ghiran I, Nicholson-Weller A, Finberg RW, Tsokos GC, Fingeroth JD. Human Complement Receptor Type 1/CD35 Is an Epstein-Barr Virus Receptor. Cell Rep. 2013 Feb 21; 3(2):371-85.
    View in: PubMed
  17. Moulton VR, Grammatikos AP, Fitzgerald LM, Tsokos GC. Splicing factor SF2/ASF rescues IL-2 production in T cells from systemic lupus erythematosus patients by activating IL-2 transcription. Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5):1845-50.
    View in: PubMed
  18. Del Rio R, McAllister RD, Meeker ND, Wall EH, Bond JP, Kyttaris VC, Tsokos GC, Tung KS, Teuscher C. Identification of Orch3, a Locus Controlling Dominant Resistance to Autoimmune Orchitis, as Kinesin Family Member 1C. PLoS Genet. 2012 Dec; 8(12):e1003140.
    View in: PubMed
  19. Rauen T, Grammatikos AP, Hedrich CM, Floege J, Tenbrock K, Ohl K, Kyttaris VC, Tsokos GC. cAMP-responsive Element Modulator a (CREMa) Contributes to Decreased Notch-1 Expression in T Cells from Patients with Active Systemic Lupus Erythematosus (SLE). J Biol Chem. 2012 Dec 14; 287(51):42525-32.
    View in: PubMed
  20. Tsokos GC, Thai TH. Interleukin-2 in systemic autoimmunity hits the micro way. Arthritis Rheum. 2012 Nov; 64(11):3494-7.
    View in: PubMed
  21. Dalle Lucca JJ, Li Y, Simovic MO, Slack JL, Cap A, Falabella MJ, Dubick M, Lebeda F, Tsokos GC. Decay-accelerating factor limits hemorrhage-instigated tissue injury and improves resuscitation clinical parameters. J Surg Res. 2013 Jan; 179(1):153-67.
    View in: PubMed
  22. Ioannou A, Lieberman LA, Lucca JJ, Tsokos GC. Complement depletion protects lupus-prone mice from ischemia-reperfusion-initiated organ injury. Am J Physiol Gastrointest Liver Physiol. 2013 Feb; 304(3):G283-92.
    View in: PubMed
  23. Hedrich CM, Crispin JC, Rauen T, Ioannidis C, Apostolidis SA, Lo MS, Kyttaris VC, Tsokos GC. cAMP response element modulator a controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus. Proc Natl Acad Sci U S A. 2012 Oct 9; 109(41):16606-11.
    View in: PubMed
  24. Chatterjee M, Hedrich CM, Rauen T, Ioannidis C, Terhorst C, Tsokos GC. CD3-T Cell Receptor Co-stimulation through SLAMF3 and SLAMF6 Receptors Enhances ROR?t Recruitment to the IL17A Promoter in Human T Lymphocytes. J Biol Chem. 2012 Nov 2; 287(45):38168-77.
    View in: PubMed
  25. Ioannou A, Kannan L, Tsokos GC. Platelets, complement and tissue inflammation. Autoimmunity. 2013 Feb; 46(1):1-5.
    View in: PubMed
  26. Koga T, Ichinose K, Mizui M, Crispín JC, Tsokos GC. Calcium/calmodulin-dependent protein kinase IV suppresses IL-2 production and regulatory T cell activity in lupus. J Immunol. 2012 Oct 1; 189(7):3490-6.
    View in: PubMed
  27. Rosetti F, Tsuboi N, Chen K, Nishi H, Ernandez T, Sethi S, Croce K, Stavrakis G, Alcocer-Varela J, Gómez-Martin D, van Rooijen N, Kyttaris VC, Lichtman AH, Tsokos GC, Mayadas TN. Human lupus serum induces neutrophil-mediated organ damage in mice that is enabled by Mac-1 deficiency. J Immunol. 2012 Oct 1; 189(7):3714-23.
    View in: PubMed
  28. Stielke S, Keilhoff G, Kirches E, Mertens PR, Neumann KH, Tsokos GC, Mawrin C. Adhesion molecule expression precedes brain damages of lupus-prone mice and correlates with kidney pathology. J Neuroimmunol. 2012 Nov 15; 252(1-2):24-32.
    View in: PubMed
  29. Borschukova O, Paz Z, Ghiran IC, Liu CC, Kao AH, Manzi S, Ahearn JM, Tsokos GC. Complement fragment C3d is colocalized within the lipid rafts of T cells and promotes cytokine production. Lupus. 2012 Oct; 21(12):1294-304.
    View in: PubMed
  30. Lapchak PH, Ioannou A, Rani P, Lieberman LA, Yoshiya K, Kannan L, Dalle Lucca JJ, Kowalska MA, Tsokos GC. The role of platelet factor 4 in local and remote tissue damage in a mouse model of mesenteric ischemia/reperfusion injury. PLoS One. 2012; 7(7):e39934.
    View in: PubMed
  31. Dalle Lucca JJ, Li Y, Simovic M, Pusateri AE, Falabella M, Dubick MA, Tsokos GC. Effects of C1 inhibitor on tissue damage in a porcine model of controlled hemorrhage. Shock. 2012 Jul; 38(1):82-91.
    View in: PubMed
  32. Detre C, Keszei M, Garrido-Mesa N, Kis-Toth K, Castro W, Agyemang AF, Veerapen N, Besra GS, Carroll MC, Tsokos GC, Wang N, Leadbetter EA, Terhorst C. SAP expression in invariant NKT cells is required for cognate help to support B-cell responses. Blood. 2012 Jul 5; 120(1):122-9.
    View in: PubMed
  33. Moulton VR, Holcomb DR, Zajdel MC, Tsokos GC. Estrogen upregulates cyclic AMP response element modulator a expression and downregulates interleukin-2 production by human T lymphocytes. Mol Med. 2012; 18(1):370-8.
    View in: PubMed
  34. Moulton VR, Tsokos GC. Why do women get lupus? Clin Immunol. 2012 Jul; 144(1):53-6.
    View in: PubMed
  35. Lapchak PH, Kannan L, Rani P, Pamuk ON, Ioannou A, Dalle Lucca JJ, Pine P, Tsokos GC. Inhibition of Syk activity by R788 in platelets prevents remote lung tissue damage after mesenteric ischemia-reperfusion injury. Am J Physiol Gastrointest Liver Physiol. 2012 Jun 15; 302(12):G1416-22.
    View in: PubMed
  36. Crispín JC, Apostolidis SA, Rosetti F, Keszei M, Wang N, Terhorst C, Mayadas TN, Tsokos GC. Cutting edge: protein phosphatase 2A confers susceptibility to autoimmune disease through an IL-17-dependent mechanism. J Immunol. 2012 Apr 15; 188(8):3567-71.
    View in: PubMed
  37. Hofmann SR, Rösen-Wolff A, Tsokos GC, Hedrich CM. Biological properties and regulation of IL-10 related cytokines and their contribution to autoimmune disease and tissue injury. Clin Immunol. 2012 May; 143(2):116-27.
    View in: PubMed
  38. Ghosh D, Kis-Toth K, Juang YT, Tsokos GC. CREMa suppresses spleen tyrosine kinase expression in normal but not systemic lupus erythematosus T cells. Arthritis Rheum. 2012 Mar; 64(3):799-807.
    View in: PubMed
  39. Lapchak PH, Ioannou A, Kannan L, Rani P, Dalle Lucca JJ, Tsokos GC. Platelet-associated CD40/CD154 mediates remote tissue damage after mesenteric ischemia/reperfusion injury. PLoS One. 2012; 7(2):e32260.
    View in: PubMed
  40. Ghosh D, Tsokos GC, Kyttaris VC. c-Jun and Ets2 proteins regulate expression of spleen tyrosine kinase in T cells. J Biol Chem. 2012 Apr 6; 287(15):11833-41.
    View in: PubMed
  41. Lippe R, Ohl K, Varga G, Rauen T, Crispin JC, Juang YT, Kuerten S, Tacke F, Wolf M, Roebrock K, Vogl T, Verjans E, Honke N, Ehrchen J, Foell D, Skryabin B, Wagner N, Tsokos GC, Roth J, Tenbrock K. CREMa overexpression decreases IL-2 production, induces a T(H)17 phenotype and accelerates autoimmunity. J Mol Cell Biol. 2012 Apr; 4(2):121-3.
    View in: PubMed
  42. Lapchak PH, Kannan L, Ioannou A, Rani P, Karian P, Dalle Lucca JJ, Tsokos GC. Platelets orchestrate remote tissue damage after mesenteric ischemia-reperfusion. Am J Physiol Gastrointest Liver Physiol. 2012 Apr 15; 302(8):G888-97.
    View in: PubMed
  43. Kitas GD, Tsokos GC, Van Riel P. Excellence in Rheumatology 2012 25-28 January Madrid. Int J Rheum Dis. 2012 Feb; 15(1):e17-8.
    View in: PubMed
  44. Recher M, Burns SO, de la Fuente MA, Volpi S, Dahlberg C, Walter JE, Moffitt K, Mathew D, Honke N, Lang PA, Patrizi L, Falet H, Keszei M, Mizui M, Csizmadia E, Candotti F, Nadeau K, Bouma G, Delmonte OM, Frugoni F, Fomin AB, Buchbinder D, Lundequist EM, Massaad MJ, Tsokos GC, Hartwig J, Manis J, Terhorst C, Geha RS, Snapper S, Lang KS, Malley R, Westerberg L, Thrasher AJ, Notarangelo LD. B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Blood. 2012 Mar 22; 119(12):2819-28.
    View in: PubMed
  45. Rauen T, Juang YT, Hedrich CM, Kis-Toth K, Tsokos GC. A novel isoform of the orphan receptor ROR?t suppresses IL-17 production in human T cells. Genes Immun. 2012 Jun; 13(4):346-50.
    View in: PubMed
  46. Lo MS, Tsokos GC. Treatment of systemic lupus erythematosus: new advances in targeted therapy. Ann N Y Acad Sci. 2012 Jan; 1247:138-52.
    View in: PubMed
  47. Moulton VR, Lo MS, Tsokos GC. Methods and protocols to study T cell signaling abnormalities in human systemic lupus erythematosus. Methods Mol Biol. 2012; 900:25-60.
    View in: PubMed
  48. Tsokos GC. [In Process Citation]. Nihon Rinsho Meneki Gakkai Kaishi. 2012; 35(4):335b.
    View in: PubMed
  49. Poole BD, Niewold TB, Tsokos GC. Cytokines in systemic lupus erythematosus 2011. J Biomed Biotechnol. 2012; 2012:427824.
    View in: PubMed
  50. Chatterjee M, Rauen T, Kis-Toth K, Kyttaris VC, Hedrich CM, Terhorst C, Tsokos GC. Increased expression of SLAM receptors SLAMF3 and SLAMF6 in systemic lupus erythematosus T lymphocytes promotes Th17 differentiation. J Immunol. 2012 Feb 1; 188(3):1206-12.
    View in: PubMed
  51. Hedrich CM, Rauen T, Kis-Toth K, Kyttaris VC, Tsokos GC. cAMP-responsive element modulator a (CREMa) suppresses IL-17F protein expression in T lymphocytes from patients with systemic lupus erythematosus (SLE). J Biol Chem. 2012 Feb 10; 287(7):4715-25.
    View in: PubMed
  52. Grammatikos AP, Tsokos GC. Immunodeficiency and autoimmunity: lessons from systemic lupus erythematosus. Trends Mol Med. 2012 Feb; 18(2):101-8.
    View in: PubMed
  53. Tsokos GC. Systemic lupus erythematosus. N Engl J Med. 2011 Dec 1; 365(22):2110-21.
    View in: PubMed
  54. Ichinose K, Rauen T, Juang YT, Kis-Toth K, Mizui M, Koga T, Tsokos GC. Cutting edge: Calcium/Calmodulin-dependent protein kinase type IV is essential for mesangial cell proliferation and lupus nephritis. J Immunol. 2011 Dec 1; 187(11):5500-4.
    View in: PubMed
  55. Rauen T, Hedrich CM, Juang YT, Tenbrock K, Tsokos GC. cAMP-responsive element modulator (CREM)a protein induces interleukin 17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic lupus erythematosus. J Biol Chem. 2011 Dec 16; 286(50):43437-46.
    View in: PubMed
  56. Hedrich CM, Rauen T, Tsokos GC. cAMP-responsive element modulator (CREM)a protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus. J Biol Chem. 2011 Dec 16; 286(50):43429-36.
    View in: PubMed
  57. Sfikakis PP, Tsokos GC. Towards the next generation of anti-TNF drugs. Clin Immunol. 2011 Dec; 141(3):231-5.
    View in: PubMed
  58. Yoshiya K, Lapchak PH, Thai TH, Kannan L, Rani P, Dalle Lucca JJ, Tsokos GC. Depletion of gut commensal bacteria attenuates intestinal ischemia/reperfusion injury. Am J Physiol Gastrointest Liver Physiol. 2011 Dec; 301(6):G1020-30.
    View in: PubMed
  59. Tan W, Sunahori K, Zhao J, Deng Y, Kaufman KM, Kelly JA, Langefeld CD, Williams AH, Comeau ME, Ziegler JT, Marion MC, Bae SC, Lee JH, Lee JS, Chang DM, Song YW, Yu CY, Kimberly RP, Edberg JC, Brown EE, Petri MA, Ramsey-Goldman R, Vilá LM, Reveille JD, Alarcón-Riquelme ME, Harley JB, Boackle SA, Stevens AM, Scofield RH, Merrill JT, Freedman BI, Anaya JM, Criswell LA, Jacob CO, Vyse TJ, Niewold TB, Gaffney PM, Moser KL, Gilkeson GS, Kamen DL, James JA, Grossman JM, Hahn BH, Tsokos GC, Tsao BP, Alarcón GS. Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups. Arthritis Rheum. 2011 Sep; 63(9):2755-63.
    View in: PubMed
  60. Kyttaris VC, Tsokos GC. Targeting lymphocyte signaling pathways as a therapeutic approach to systemic lupus erythematosus. Curr Opin Rheumatol. 2011 Sep; 23(5):449-53.
    View in: PubMed
  61. Apostolidis SA, Lieberman LA, Kis-Toth K, Crispín JC, Tsokos GC. The dysregulation of cytokine networks in systemic lupus erythematosus. J Interferon Cytokine Res. 2011 Oct; 31(10):769-79.
    View in: PubMed
  62. Hedrich CM, Tsokos GC. Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases. Trends Mol Med. 2011 Dec; 17(12):714-24.
    View in: PubMed
  63. Ioannou A, Dalle Lucca J, Tsokos GC. Immunopathogenesis of ischemia/reperfusion-associated tissue damage. Clin Immunol. 2011 Oct; 141(1):3-14.
    View in: PubMed
  64. Rauen T, Benedyk K, Juang YT, Kerkhoff C, Kyttaris VC, Roth J, Tsokos GC, Tenbrock K. A novel intronic cAMP response element modulator (CREM) promoter is regulated by activator protein-1 (AP-1) and accounts for altered activation-induced CREM expression in T cells from patients with systemic lupus erythematosus. J Biol Chem. 2011 Sep 16; 286(37):32366-72.
    View in: PubMed
  65. Crispín JC, Apostolidis SA, Finnell MI, Tsokos GC. Induction of PP2A Bß, a regulator of IL-2 deprivation-induced T-cell apoptosis, is deficient in systemic lupus erythematosus. Proc Natl Acad Sci U S A. 2011 Jul 26; 108(30):12443-8.
    View in: PubMed
  66. Tun-Kyi A, Finn G, Greenwood A, Nowak M, Lee TH, Asara JM, Tsokos GC, Fitzgerald K, Israel E, Li X, Exley M, Nicholson LK, Lu KP. Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunity. Nat Immunol. 2011 Aug; 12(8):733-41.
    View in: PubMed
  67. Dalle Lucca JJ, Simovic M, Li Y, Moratz C, Falabella M, Tsokos GC. Decay-accelerating factor mitigates controlled hemorrhage-instigated intestinal and lung tissue damage and hyperkalemia in swine. J Trauma. 2011 Jul; 71(1 Suppl):S151-60.
    View in: PubMed
  68. Kyttaris VC, Zhang Z, Kampagianni O, Tsokos GC. Calcium signaling in systemic lupus erythematosus T cells: a treatment target. Arthritis Rheum. 2011 Jul; 63(7):2058-66.
    View in: PubMed
  69. Kis-Toth K, Szanto A, Thai TH, Tsokos GC. Cytosolic DNA-activated human dendritic cells are potent activators of the adaptive immune response. J Immunol. 2011 Aug 1; 187(3):1222-34.
    View in: PubMed
  70. Poole BD, Niewold TB, Tsokos GC, Via CS. Cytokines in systemic lupus erythematosus. J Biomed Biotechnol. 2010; 2010:735169.
    View in: PubMed
  71. Moulton VR, Tsokos GC. Abnormalities of T cell signaling in systemic lupus erythematosus. Arthritis Res Ther. 2011; 13(2):207.
    View in: PubMed
  72. Sunahori K, Juang YT, Kyttaris VC, Tsokos GC. Promoter hypomethylation results in increased expression of protein phosphatase 2A in T cells from patients with systemic lupus erythematosus. J Immunol. 2011 Apr 1; 186(7):4508-17.
    View in: PubMed
  73. Ghiran IC, Zeidel ML, Shevkoplyas SS, Burns JM, Tsokos GC, Kyttaris VC. Systemic lupus erythematosus serum deposits C4d on red blood cells, decreases red blood cell membrane deformability, and promotes nitric oxide production. Arthritis Rheum. 2011 Feb; 63(2):503-12.
    View in: PubMed
  74. Apostolidis SA, Crispín JC, Tsokos GC. IL-17-producing T cells in lupus nephritis. Lupus. 2011 Feb; 20(2):120-4.
    View in: PubMed
  75. Ichinose K, Juang YT, Crispín JC, Kis-Toth K, Tsokos GC. Suppression of autoimmunity and organ pathology in lupus-prone mice upon inhibition of calcium/calmodulin-dependent protein kinase type IV. Arthritis Rheum. 2011 Feb; 63(2):523-9.
    View in: PubMed
  76. Chatterjee M, Kis-Toth K, Thai TH, Terhorst C, Tsokos GC. SLAMF6-driven co-stimulation of human peripheral T cells is defective in SLE T cells. Autoimmunity. 2011 May; 44(3):211-8.
    View in: PubMed
  77. Pamuk ON, Tsokos GC. Spleen tyrosine kinase inhibition in the treatment of autoimmune, allergic and autoinflammatory diseases. Arthritis Res Ther. 2010; 12(6):222.
    View in: PubMed
  78. Juang YT, Peoples C, Kafri R, Kyttaris VC, Sunahori K, Kis-Toth K, Fitzgerald L, Ergin S, Finnell M, Tsokos GC. A systemic lupus erythematosus gene expression array in disease diagnosis and classification: a preliminary report. Lupus. 2011 Mar; 20(3):243-9.
    View in: PubMed
  79. Juang YT, Rauen T, Wang Y, Ichinose K, Benedyk K, Tenbrock K, Tsokos GC. Transcriptional activation of the cAMP-responsive modulator promoter in human T cells is regulated by protein phosphatase 2A-mediated dephosphorylation of SP-1 and reflects disease activity in patients with systemic lupus erythematosus. J Biol Chem. 2011 Jan 21; 286(3):1795-801.
    View in: PubMed
  80. Crispín JC, Tsokos GC. Interleukin-17-producing T cells in lupus. Curr Opin Rheumatol. 2010 Sep; 22(5):499-503.
    View in: PubMed
  81. Thai TH, Christiansen PA, Tsokos GC. Is there a link between dysregulated miRNA expression and disease? Discov Med. 2010 Sep; 10(52):184-94.
    View in: PubMed
  82. Deng GM, Liu L, Tsokos GC. Targeted tumor necrosis factor receptor I preligand assembly domain improves skin lesions in MRL/lpr mice. Arthritis Rheum. 2010 Aug; 62(8):2424-31.
    View in: PubMed
  83. Deng GM, Liu L, Bahjat FR, Pine PR, Tsokos GC. Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus-prone mice. Arthritis Rheum. 2010 Jul; 62(7):2086-92.
    View in: PubMed
  84. Spadafora C, Awandare GA, Kopydlowski KM, Czege J, Moch JK, Finberg RW, Tsokos GC, Stoute JA. Complement receptor 1 is a sialic acid-independent erythrocyte receptor of Plasmodium falciparum. PLoS Pathog. 2010; 6(6):e1000968.
    View in: PubMed
  85. Lieberman LA, Tsokos GC. The IL-2 defect in systemic lupus erythematosus disease has an expansive effect on host immunity. J Biomed Biotechnol. 2010; 2010:740619.
    View in: PubMed
  86. Pamuk ON, Lapchak PH, Rani P, Pine P, Dalle Lucca JJ, Tsokos GC. Spleen tyrosine kinase inhibition prevents tissue damage after ischemia-reperfusion. Am J Physiol Gastrointest Liver Physiol. 2010 Aug; 299(2):G391-9.
    View in: PubMed
  87. Deng GM, Liu L, Kyttaris VC, Tsokos GC. Lupus serum IgG induces skin inflammation through the TNFR1 signaling pathway. J Immunol. 2010 Jun 15; 184(12):7154-61.
    View in: PubMed
  88. Crispín JC, Kyttaris VC, Terhorst C, Tsokos GC. T cells as therapeutic targets in SLE. Nat Rev Rheumatol. 2010 Jun; 6(6):317-25.
    View in: PubMed
  89. Crispín JC, Keenan BT, Finnell MD, Bermas BL, Schur P, Massarotti E, Karlson EW, Fitzgerald LM, Ergin S, Kyttaris VC, Tsokos GC, Costenbader KH. Expression of CD44 variant isoforms CD44v3 and CD44v6 is increased on T cells from patients with systemic lupus erythematosus and is correlated with disease activity. Arthritis Rheum. 2010 May; 62(5):1431-7.
    View in: PubMed
  90. Wang Y, Li Y, Dalle Lucca SL, Simovic M, Tsokos GC, Dalle Lucca JJ. Decay accelerating factor (CD55) protects neuronal cells from chemical hypoxia-induced injury. J Neuroinflammation. 2010; 7:24.
    View in: PubMed
  91. Crispín JC, Tsokos GC. IL-17 in systemic lupus erythematosus. J Biomed Biotechnol. 2010; 2010:943254.
    View in: PubMed
  92. Kyttaris VC, Zhang Z, Kuchroo VK, Oukka M, Tsokos GC. Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice. J Immunol. 2010 May 1; 184(9):4605-9.
    View in: PubMed
  93. Kis-Toth K, Tsokos GC. Dendritic cell function in lupus: Independent contributors or victims of aberrant immune regulation. Autoimmunity. 2010 Mar; 43(2):121-30.
    View in: PubMed
  94. Detre C, Keszei M, Romero X, Tsokos GC, Terhorst C. SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions. Semin Immunopathol. 2010 Jun; 32(2):157-71.
    View in: PubMed
  95. Tsokos GC. Sixth school in systemic autoimmune diseases. Autoimmun Rev. 2010 May; 9(7):471-2.
    View in: PubMed
  96. Crispín JC, Liossis SN, Kis-Toth K, Lieberman LA, Kyttaris VC, Juang YT, Tsokos GC. Pathogenesis of human systemic lupus erythematosus: recent advances. Trends Mol Med. 2010 Feb; 16(2):47-57.
    View in: PubMed
  97. Ghosh D, Tsokos GC. Spleen tyrosine kinase: an Src family of non-receptor kinase has multiple functions and represents a valuable therapeutic target in the treatment of autoimmune and inflammatory diseases. Autoimmunity. 2010 Feb; 43(1):48-55.
    View in: PubMed
  98. Moulton VR, Tsokos GC. Alternative splicing factor/splicing factor 2 regulates the expression of the zeta subunit of the human T cell receptor-associated CD3 complex. J Biol Chem. 2010 Apr 23; 285(17):12490-6.
    View in: PubMed
  99. Mayadas TN, Tsokos GC, Tsuboi N. Mechanisms of immune complex-mediated neutrophil recruitment and tissue injury. Circulation. 2009 Nov 17; 120(20):2012-24.
    View in: PubMed
  100. Lu X, Li Y, Simovic MO, Peckham R, Wang Y, Tsokos GC, Dalle Lucca JJ. Decay-accelerating factor attenuates C-reactive protein-potentiated tissue injury after mesenteric ischemia/reperfusion. J Surg Res. 2011 May 15; 167(2):e103-15.
    View in: PubMed
  101. Crispín JC, Tsokos GC. Human TCR-alpha beta+ CD4- CD8- T cells can derive from CD8+ T cells and display an inflammatory effector phenotype. J Immunol. 2009 Oct 1; 183(7):4675-81.
    View in: PubMed
  102. Zhang Z, Kyttaris VC, Tsokos GC. The role of IL-23/IL-17 axis in lupus nephritis. J Immunol. 2009 Sep 1; 183(5):3160-9.
    View in: PubMed
  103. Nalbandian A, Crispín JC, Tsokos GC. Interleukin-17 and systemic lupus erythematosus: current concepts. Clin Exp Immunol. 2009 Aug; 157(2):209-15.
    View in: PubMed
  104. Chen J, Crispín JC, Dalle Lucca J, Tsokos GC. A novel inhibitor of the alternative pathway of complement attenuates intestinal ischemia/reperfusion-induced injury. J Surg Res. 2011 May 15; 167(2):e131-6.
    View in: PubMed
  105. Wu HY, Center EM, Tsokos GC, Weiner HL. Suppression of murine SLE by oral anti-CD3: inducible CD4+CD25-LAP+ regulatory T cells control the expansion of IL-17+ follicular helper T cells. Lupus. 2009 Jun; 18(7):586-96.
    View in: PubMed
  106. Avalos I, Tsokos GC. The role of complement in the antiphospholipid syndrome-associated pathology. Clin Rev Allergy Immunol. 2009 Jun; 36(2-3):141-4.
    View in: PubMed
  107. Kulik L, Fleming SD, Moratz C, Reuter JW, Novikov A, Chen K, Andrews KA, Markaryan A, Quigg RJ, Silverman GJ, Tsokos GC, Holers VM. Pathogenic natural antibodies recognizing annexin IV are required to develop intestinal ischemia-reperfusion injury. J Immunol. 2009 May 1; 182(9):5363-73.
    View in: PubMed
  108. Ahlmann M, Varga G, Sturm K, Lippe R, Benedyk K, Viemann D, Scholzen T, Ehrchen J, Müller FU, Seidl M, Matus M, Tsokos GC, Roth J, Tenbrock K. The cyclic AMP response element modulator {alpha} suppresses CD86 expression and APC function. J Immunol. 2009 Apr 1; 182(7):4167-74.
    View in: PubMed
  109. Chen J, Crispín JC, Tedder TF, Dalle Lucca J, Tsokos GC. B cells contribute to ischemia/reperfusion-mediated tissue injury. J Autoimmun. 2009 May-Jun; 32(3-4):195-200.
    View in: PubMed
  110. Sunahori K, Juang YT, Tsokos GC. Methylation status of CpG islands flanking a cAMP response element motif on the protein phosphatase 2Ac alpha promoter determines CREB binding and activity. J Immunol. 2009 Feb 1; 182(3):1500-8.
    View in: PubMed
  111. Shi T, Moulton VR, Lapchak PH, Deng GM, Dalle Lucca JJ, Tsokos GC. Ischemia-mediated aggregation of the actin cytoskeleton is one of the major initial events resulting in ischemia-reperfusion injury. Am J Physiol Gastrointest Liver Physiol. 2009 Feb; 296(2):G339-47.
    View in: PubMed
  112. Crispín JC, Oukka M, Bayliss G, Cohen RA, Van Beek CA, Stillman IE, Kyttaris VC, Juang YT, Tsokos GC. Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys. J Immunol. 2008 Dec 15; 181(12):8761-6.
    View in: PubMed
  113. Edgerton C, Crispín JC, Moratz CM, Bettelli E, Oukka M, Simovic M, Zacharia A, Egan R, Chen J, Dalle Lucca JJ, Juang YT, Tsokos GC. IL-17 producing CD4+ T cells mediate accelerated ischemia/reperfusion-induced injury in autoimmunity-prone mice. Clin Immunol. 2009 Mar; 130(3):313-21.
    View in: PubMed
  114. Krishnan S, Juang YT, Chowdhury B, Magilavy A, Fisher CU, Nguyen H, Nambiar MP, Kyttaris V, Weinstein A, Bahjat R, Pine P, Rus V, Tsokos GC. Differential expression and molecular associations of Syk in systemic lupus erythematosus T cells. J Immunol. 2008 Dec 1; 181(11):8145-52.
    View in: PubMed
  115. Deng GM, Tsokos GC. Cholera toxin B accelerates disease progression in lupus-prone mice by promoting lipid raft aggregation. J Immunol. 2008 Sep 15; 181(6):4019-26.
    View in: PubMed
  116. Juang YT, Wang Y, Jiang G, Peng HB, Ergin S, Finnell M, Magilavy A, Kyttaris VC, Tsokos GC. PP2A dephosphorylates Elf-1 and determines the expression of CD3zeta and FcRgamma in human systemic lupus erythematosus T cells. J Immunol. 2008 Sep 1; 181(5):3658-64.
    View in: PubMed
  117. Crispín JC, Tsokos GC. Transcriptional regulation of IL-2 in health and autoimmunity. Autoimmun Rev. 2009 Jan; 8(3):190-5.
    View in: PubMed
  118. Cohen RA, Bayliss G, Crispin JC, Kane-Wanger GF, Van Beek CA, Kyttaris VC, Avalos I, Yu CY, Tsokos GC, Stillman IE. T cells and in situ cryoglobulin deposition in the pathogenesis of lupus nephritis. Clin Immunol. 2008 Jul; 128(1):1-7.
    View in: PubMed
  119. Moulton VR, Kyttaris VC, Juang YT, Chowdhury B, Tsokos GC. The RNA-stabilizing protein HuR regulates the expression of zeta chain of the human T cell receptor-associated CD3 complex. J Biol Chem. 2008 Jul 18; 283(29):20037-44.
    View in: PubMed
  120. Tsokos GC. Calcium signaling in systemic lupus erythematosus lymphocytes and its therapeutic exploitation. Arthritis Rheum. 2008 May; 58(5):1216-9.
    View in: PubMed
  121. Fleming SD, Phillips LM, Lambris JD, Tsokos GC. Complement component C5a mediates hemorrhage-induced intestinal damage. J Surg Res. 2008 Dec; 150(2):196-203.
    View in: PubMed
  122. Crispín JC, Kyttaris VC, Juang YT, Tsokos GC. How signaling and gene transcription aberrations dictate the systemic lupus erythematosus T cell phenotype. Trends Immunol. 2008 Mar; 29(3):110-5.
    View in: PubMed
  123. Haymore BR, Mikita CP, Tsokos GC. Common variable immune deficiency (CVID) presenting as an autoimmune disease: role of memory B cells. Autoimmun Rev. 2008 Feb; 7(4):309-12.
    View in: PubMed
  124. Crispín JC, Tsokos GC. Novel molecular targets in the treatment of systemic lupus erythematosus. Autoimmun Rev. 2008 Jan; 7(3):256-61.
    View in: PubMed
  125. Crispín JC, Kyttaris V, Juang YT, Tsokos GC. Systemic lupus erythematosus: new molecular targets. Ann Rheum Dis. 2007 Nov; 66 Suppl 3:iii65-9.
    View in: PubMed
  126. Juang YT, Sumibcay L, Tolnay M, Wang Y, Kyttaris VC, Tsokos GC. Elf-1 binds to GGAA elements on the FcRgamma promoter and represses its expression. J Immunol. 2007 Oct 1; 179(7):4884-9.
    View in: PubMed
  127. Gibson HM, Hedgcock CJ, Aufiero BM, Wilson AJ, Hafner MS, Tsokos GC, Wong HK. Induction of the CTLA-4 gene in human lymphocytes is dependent on NFAT binding the proximal promoter. J Immunol. 2007 Sep 15; 179(6):3831-40.
    View in: PubMed
  128. Bergmann-Leitner ES, Duncan EH, Leitner WW, Neutzner A, Savranskaya T, Angov E, Tsokos GC. C3d-defined complement receptor-binding peptide p28 conjugated to circumsporozoite protein provides protection against Plasmodium berghei. Vaccine. 2007 Nov 7; 25(45):7732-6.
    View in: PubMed
  129. Okoye FI, Krishnan S, Chandok MR, Tsokos GC, Farber DL. Proximal signaling control of human effector CD4 T cell function. Clin Immunol. 2007 Oct; 125(1):5-15.
    View in: PubMed
  130. Kyttaris VC, Tsokos GC. Syk kinase as a treatment target for therapy in autoimmune diseases. Clin Immunol. 2007 Sep; 124(3):235-7.
    View in: PubMed
  131. Weeks C, Moratz C, Zacharia A, Stracener C, Egan R, Peckham R, Moore FD, Tsokos GC. Decay-accelerating factor attenuates remote ischemia-reperfusion-initiated organ damage. Clin Immunol. 2007 Sep; 124(3):311-27.
    View in: PubMed
  132. Tenbrock K, Juang YT, Kyttaris VC, Tsokos GC. Altered signal transduction in SLE T cells. Rheumatology (Oxford). 2007 Oct; 46(10):1525-30.
    View in: PubMed
  133. Kiang JG, Bowman PD, Lu X, Li Y, Wu BW, Loh HH, Tsen KT, Tsokos GC. Geldanamycin inhibits hemorrhage-induced increases in caspase-3 activity: role of inducible nitric oxide synthase. J Appl Physiol. 2007 Sep; 103(3):1045-55.
    View in: PubMed
  134. Keith MP, Moratz C, Egan R, Zacharia A, Greidinger EL, Hoffman RW, Tsokos GC. Anti-ribonucleoprotein antibodies mediate enhanced lung injury following mesenteric ischemia/reperfusion in Rag-1(-/-) mice. Autoimmunity. 2007 May; 40(3):208-16.
    View in: PubMed
  135. Li Y, Harada T, Juang YT, Kyttaris VC, Wang Y, Zidanic M, Tung K, Tsokos GC. Phosphorylated ERM is responsible for increased T cell polarization, adhesion, and migration in patients with systemic lupus erythematosus. J Immunol. 2007 Feb 1; 178(3):1938-47.
    View in: PubMed
  136. Harada T, Kyttaris V, Li Y, Juang YT, Wang Y, Tsokos GC. Increased expression of STAT3 in SLE T cells contributes to enhanced chemokine-mediated cell migration. Autoimmunity. 2007 Feb; 40(1):1-8.
    View in: PubMed
  137. Kyttaris VC, Wang Y, Juang YT, Weinstein A, Tsokos GC. Increased levels of NF-ATc2 differentially regulate CD154 and IL-2 genes in T cells from patients with systemic lupus erythematosus. J Immunol. 2007 Feb 1; 178(3):1960-6.
    View in: PubMed
  138. Liapis H, Tsokos GC. Pathology and immunology of lupus glomerulonephritis: can we bridge the two? Int Urol Nephrol. 2007; 39(1):223-31.
    View in: PubMed
  139. Chowdhury B, Krishnan S, Tsokos CG, Robertson JW, Fisher CU, Nambiar MP, Tsokos GC. Stability and translation of TCR zeta mRNA are regulated by the adenosine-uridine-rich elements in splice-deleted 3' untranslated region of zeta-chain. J Immunol. 2006 Dec 1; 177(11):8248-57.
    View in: PubMed
  140. Kyttaris VC, Krishnan S, Tsokos GC. Systems biology in systemic lupus erythematosus: integrating genes, biology and immune function. Autoimmunity. 2006 Dec; 39(8):705-9.
    View in: PubMed
  141. Lopez-Santalla M, Krishnan S, Valeri AP, Aguilera-Montilla N, Fisher CU, Perez-Blas M, Gutierrez-Calvo A, Lasa I, Granell-Vicent J, Tsokos GC, Martin-Villa JM. FcRgamma chain does not replace CD3zeta chain in CD3zeta-deficient T lymphocytes of patients with gastric adenocarcinoma. Mol Immunol. 2007 Mar; 44(9):2400-5.
    View in: PubMed
  142. Kiang JG, Peckham RM, Duke LE, Shimizu T, Chaudry IH, Tsokos GC. Androstenediol inhibits the trauma-hemorrhage-induced increase in caspase-3 by downregulating the inducible nitric oxide synthase pathway. J Appl Physiol. 2007 Mar; 102(3):933-41.
    View in: PubMed
  143. Tenbrock K, Juang YT, Leukert N, Roth J, Tsokos GC. The transcriptional repressor cAMP response element modulator alpha interacts with histone deacetylase 1 to repress promoter activity. J Immunol. 2006 Nov 1; 177(9):6159-64.
    View in: PubMed
  144. Peckham RM, Handrigan MT, Bentley TB, Falabella MJ, Chrovian AD, Stahl GL, Tsokos GC. C5-blocking antibody reduces fluid requirements and improves responsiveness to fluid infusion in hemorrhagic shock managed with hypotensive resuscitation. J Appl Physiol. 2007 Feb; 102(2):673-80.
    View in: PubMed
  145. Katz U, Tsokos GC. 2006 clinical immunology school on systemic autoimmune diseases. Autoimmun Rev. 2007 Mar; 6(4):203.
    View in: PubMed
  146. Keith MP, Moratz C, Tsokos GC. Anti-RNP immunity: implications for tissue injury and the pathogenesis of connective tissue disease. Autoimmun Rev. 2007 Mar; 6(4):232-6.
    View in: PubMed
  147. Bergmann-Leitner ES, Leitner WW, Tsokos GC. Complement 3d: from molecular adjuvant to target of immune escape mechanisms. Clin Immunol. 2006 Nov; 121(2):177-85.
    View in: PubMed
  148. Wong HK, Tsokos GC. Fas (CD95) ligation inhibits activation of NF-kappa B by targeting p65-Rel A in a caspase-dependent manner. Clin Immunol. 2006 Oct; 121(1):47-53.
    View in: PubMed
  149. Krishnan S, Chowdhury B, Tsokos GC. Autoimmunity in systemic lupus erythematosus: integrating genes and biology. Semin Immunol. 2006 Aug; 18(4):230-43.
    View in: PubMed
  150. Lopez-Santalla M, Krishnan S, Valeri AP, Aguilera-Montilla N, Fisher CU, Perez-Blas M, Gutierrez-Calvo A, Lasa I, Granell-Vicent J, Tsokos GC, Martin-Villa JM. Defective CD3zeta chain expression in Herpesvirus saimiri (HVS)-derived T-cell lines in gastric adenocarcinoma. Cell Immunol. 2005 Dec; 238(2):113-22.
    View in: PubMed
  151. Kiang JG, Bowman PD, Lu X, Li Y, Ding XZ, Zhao B, Juang YT, Atkins JL, Tsokos GC. Geldanamycin prevents hemorrhage-induced ATP loss by overexpressing inducible HSP70 and activating pyruvate dehydrogenase. Am J Physiol Gastrointest Liver Physiol. 2006 Jul; 291(1):G117-27.
    View in: PubMed
  152. Mamula MJ, Farber DL, Tsokos GC. Autoimmune odyssey on the Aegean Sea. Nat Immunol. 2006 Mar; 7(3):219-21.
    View in: PubMed
  153. Fleming SD, Tsokos GC. Complement, natural antibodies, autoantibodies and tissue injury. Autoimmun Rev. 2006 Feb; 5(2):89-92.
    View in: PubMed
  154. Tsokos GC. In the beginning was Sm. J Immunol. 2006 Feb 1; 176(3):1295-6.
    View in: PubMed
  155. Kyttaris VC, Wang Y, Juang YT, Weinstein A, Tsokos GC. CAMP response element modulator a expression in patients with systemic lupus erythematosus. Lupus. 2006; 15(12):840-4.
    View in: PubMed
  156. Kyttaris VC, Katsiari CG, Juang YT, Tsokos GC. New insights into the pathogenesis of systemic lupus erythematosus. Curr Rheumatol Rep. 2005 Dec; 7(6):469-75.
    View in: PubMed
  157. Kyttaris VC, Sfikakis PP, Juang YT, Tsokos GC. Gene therapy in systemic lupus erythematosus. Curr Gene Ther. 2005 Dec; 5(6):677-84.
    View in: PubMed
  158. Tenbrock K, Kyttaris VC, Ahlmann M, Ehrchen JM, Tolnay M, Melkonyan H, Mawrin C, Roth J, Sorg C, Juang YT, Tsokos GC. The cyclic AMP response element modulator regulates transcription of the TCR zeta-chain. J Immunol. 2005 Nov 1; 175(9):5975-80.
    View in: PubMed
  159. Katsiari CG, Kyttaris VC, Juang YT, Tsokos GC. Protein phosphatase 2A is a negative regulator of IL-2 production in patients with systemic lupus erythematosus. J Clin Invest. 2005 Nov; 115(11):3193-204.
    View in: PubMed
  160. Liossis SN, Tsokos GC. Monoclonal antibodies and fusion proteins in medicine. J Allergy Clin Immunol. 2005 Oct; 116(4):721-9; quiz 730.
    View in: PubMed
  161. Katsiari CG, Tsokos GC. Transcriptional repression of interleukin-2 in human systemic lupus erythematosus. Autoimmun Rev. 2006 Feb; 5(2):118-21.
    View in: PubMed
  162. Krishnan S, Kiang JG, Fisher CU, Nambiar MP, Nguyen HT, Kyttaris VC, Chowdhury B, Rus V, Tsokos GC. Increased caspase-3 expression and activity contribute to reduced CD3zeta expression in systemic lupus erythematosus T cells. J Immunol. 2005 Sep 1; 175(5):3417-23.
    View in: PubMed
  163. Sfikakis PP, Boletis JN, Tsokos GC. Rituximab anti-B-cell therapy in systemic lupus erythematosus: pointing to the future. Curr Opin Rheumatol. 2005 Sep; 17(5):550-7.
    View in: PubMed
  164. Kyttaris VC, Juang YT, Tsokos GC. Immune cells and cytokines in systemic lupus erythematosus: an update. Curr Opin Rheumatol. 2005 Sep; 17(5):518-22.
    View in: PubMed
  165. Tsokos GC. Systemic lupus erythematosus and Sjögren's syndrome. Curr Opin Rheumatol. 2005 Sep; 17(5):511-2.
    View in: PubMed
  166. Atkinson C, Song H, Lu B, Qiao F, Burns TA, Holers VM, Tsokos GC, Tomlinson S. Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection. J Clin Invest. 2005 Sep; 115(9):2444-53.
    View in: PubMed
  167. Herndon TM, Pirone DM, Tsokos GC, Chen CS. T cell-to-T cell clustering enhances NF-kappaB activity by a PI3K signal mediated by Cbl-b and Rho. Biochem Biophys Res Commun. 2005 Jul 15; 332(4):1133-9.
    View in: PubMed
  168. Juang YT, Wang Y, Solomou EE, Li Y, Mawrin C, Tenbrock K, Kyttaris VC, Tsokos GC. Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV. J Clin Invest. 2005 Apr; 115(4):996-1005.
    View in: PubMed
  169. Chowdhury B, Tsokos CG, Krishnan S, Robertson J, Fisher CU, Warke RG, Warke VG, Nambiar MP, Tsokos GC. Decreased stability and translation of T cell receptor zeta mRNA with an alternatively spliced 3'-untranslated region contribute to zeta chain down-regulation in patients with systemic lupus erythematosus. J Biol Chem. 2005 May 13; 280(19):18959-66.
    View in: PubMed
  170. Bergmann-Leitner ES, Scheiblhofer S, Weiss R, Duncan EH, Leitner WW, Chen D, Angov E, Khan F, Williams JL, Winter DB, Thalhamer J, Lyon JA, Tsokos GC. C3d binding to the circumsporozoite protein carboxy-terminus deviates immunity against malaria. Int Immunol. 2005 Mar; 17(3):245-55.
    View in: PubMed
  171. Anderson J, Fleming SD, Rehrig S, Tsokos GC, Basta M, Shea-Donohue T. Intravenous immunoglobulin attenuates mesenteric ischemia-reperfusion injury. Clin Immunol. 2005 Feb; 114(2):137-46.
    View in: PubMed
  172. Fleming SD, Egan RP, Chai C, Girardi G, Holers VM, Salmon J, Monestier M, Tsokos GC. Anti-phospholipid antibodies restore mesenteric ischemia/reperfusion-induced injury in complement receptor 2/complement receptor 1-deficient mice. J Immunol. 2004 Dec 1; 173(11):7055-61.
    View in: PubMed
  173. Tsokos GC. Exploring complement activation to develop biomarkers for systemic lupus erythematosus. Arthritis Rheum. 2004 Nov; 50(11):3404-7.
    View in: PubMed
  174. Kiang JG, Lu X, Tabaku LS, Bentley TB, Atkins JL, Tsokos GC. Resuscitation with lactated Ringer solution limits the expression of molecular events associated with lung injury after hemorrhage. J Appl Physiol. 2005 Feb; 98(2):550-6.
    View in: PubMed
  175. Fleming SD, Monestier M, Tsokos GC. Accelerated ischemia/reperfusion-induced injury in autoimmunity-prone mice. J Immunol. 2004 Sep 15; 173(6):4230-5.
    View in: PubMed
  176. Kyttaris VC, Tsokos GC. T lymphocytes in systemic lupus erythematosus: an update. Curr Opin Rheumatol. 2004 Sep; 16(5):548-52.
    View in: PubMed
  177. Kyttaris VC, Juang YT, Tenbrock K, Weinstein A, Tsokos GC. Cyclic adenosine 5'-monophosphate response element modulator is responsible for the decreased expression of c-fos and activator protein-1 binding in T cells from patients with systemic lupus erythematosus. J Immunol. 2004 Sep 1; 173(5):3557-63.
    View in: PubMed
  178. Tsokos GC. B cells, be gone--B-cell depletion in the treatment of rheumatoid arthritis. N Engl J Med. 2004 Jun 17; 350(25):2546-8.
    View in: PubMed
  179. Elliott MR, Shanks RA, Khan IU, Brooks JW, Burkett PJ, Nelson BJ, Kyttaris V, Juang YT, Tsokos GC, Kammer GM. Down-regulation of IL-2 production in T lymphocytes by phosphorylated protein kinase A-RIIbeta. J Immunol. 2004 Jun 15; 172(12):7804-12.
    View in: PubMed
  180. Krishnan S, Nambiar MP, Warke VG, Fisher CU, Mitchell J, Delaney N, Tsokos GC. Alterations in lipid raft composition and dynamics contribute to abnormal T cell responses in systemic lupus erythematosus. J Immunol. 2004 Jun 15; 172(12):7821-31.
    View in: PubMed
  181. Tsokos GC. Drugs, sun and T cells in lupus. Clin Exp Immunol. 2004 May; 136(2):191-3.
    View in: PubMed
  182. Tenbrock K, Tsokos GC. Transcriptional regulation of interleukin 2 in SLE T cells. Int Rev Immunol. 2004 May-Aug; 23(3-4):333-45.
    View in: PubMed
  183. Nambiar MP, Juang YT, Krishnan S, Tsokos GC. Dissecting the molecular mechanisms of TCR zeta chain downregulation and T cell signaling abnormalities in human systemic lupus erythematosus. Int Rev Immunol. 2004 May-Aug; 23(3-4):245-63.
    View in: PubMed
  184. Tsokos GC. Immune cell signaling and gene transcription in human lupus: the time has come. Int Rev Immunol. 2004 May-Aug; 23(3-4):221-4.
    View in: PubMed
  185. Kiang JG, Bowman PD, Wu BW, Hampton N, Kiang AG, Zhao B, Juang YT, Atkins JL, Tsokos GC. Geldanamycin treatment inhibits hemorrhage-induced increases in KLF6 and iNOS expression in unresuscitated mouse organs: role of inducible HSP70. J Appl Physiol. 2004 Aug; 97(2):564-9.
    View in: PubMed
  186. Katsiari CG, Tsokos GC. Re-establishment of tolerance: the prospect of developing specific treatment for human lupus. Lupus. 2004; 13(7):485-8.
    View in: PubMed
  187. Nambiar MP, Krishnan S, Warke VG, Tsokos GC. TCR zeta-chain abnormalities in human systemic lupus erythematosus. Methods Mol Med. 2004; 102:49-72.
    View in: PubMed
  188. Papanicolaou DA, Amsterdam JD, Levine S, McCann SM, Moore RC, Newbrand CH, Allen G, Nisenbaum R, Pfaff DW, Tsokos GC, Vgontzas AN, Kales A. Neuroendocrine aspects of chronic fatigue syndrome. Neuroimmunomodulation. 2004; 11(2):65-74.
    View in: PubMed
  189. Nambiar MP, Krishnan S, Tsokos GC. T-cell signaling abnormalities in human systemic lupus erythematosus. Methods Mol Med. 2004; 102:31-47.
    View in: PubMed
  190. Tsokos GC, Fleming SD. Autoimmunity, complement activation, tissue injury and reciprocal effects. Curr Dir Autoimmun. 2004; 7:149-64.
    View in: PubMed
  191. Kyttaris VC, Juang YT, Tsokos GC. Gene therapy in systemic lupus erythematosus. Lupus. 2004; 13(5):353-8.
    View in: PubMed
  192. Karpel-Massler G, Fleming SD, Kirschfink M, Tsokos GC. Human C1 esterase inhibitor attenuates murine mesenteric ischemia/reperfusion induced local organ injury. J Surg Res. 2003 Dec; 115(2):247-56.
    View in: PubMed
  193. Kiang JG, Warke VG, Tsokos GC. NaCN-induced chemical hypoxia is associated with altered gene expression. Mol Cell Biochem. 2003 Dec; 254(1-2):211-6.
    View in: PubMed
  194. Tsokos GC, Tsokos M. The TRAIL to arthritis. J Clin Invest. 2003 Nov; 112(9):1315-7.
    View in: PubMed
  195. Elliott MR, Tolnay M, Tsokos GC, Kammer GM. Protein kinase A regulatory subunit type II beta directly interacts with and suppresses CREB transcriptional activity in activated T cells. J Immunol. 2003 Oct 1; 171(7):3636-44.
    View in: PubMed
  196. Krishnan S, Farber DL, Tsokos GC. T cell rewiring in differentiation and disease. J Immunol. 2003 Oct 1; 171(7):3325-31.
    View in: PubMed
  197. Tsokos GC, Mitchell JP, Juang YT. T cell abnormalities in human and mouse lupus: intrinsic and extrinsic. Curr Opin Rheumatol. 2003 Sep; 15(5):542-7.
    View in: PubMed
  198. Fleming SD, Mastellos D, Karpel-Massler G, Shea-Donohue T, Lambris JD, Tsokos GC. C5a causes limited, polymorphonuclear cell-independent, mesenteric ischemia/reperfusion-induced injury. Clin Immunol. 2003 Sep; 108(3):263-73.
    View in: PubMed
  199. Kiang JG, McClain DE, Warke VG, Krishnan S, Tsokos GC. Constitutive NO synthase regulates the Na+/Ca2+ exchanger in human T cells: role of [Ca2+]i and tyrosine phosphorylation. J Cell Biochem. 2003 Aug 1; 89(5):1030-43.
    View in: PubMed
  200. Nambiar MP, Fisher CU, Warke VG, Krishnan S, Mitchell JP, Delaney N, Tsokos GC. Reconstitution of deficient T cell receptor zeta chain restores T cell signaling and augments T cell receptor/CD3-induced interleukin-2 production in patients with systemic lupus erythematosus. Arthritis Rheum. 2003 Jul; 48(7):1948-55.
    View in: PubMed
  201. Tsokos GC, Nambiar MP, Tenbrock K, Juang YT. Rewiring the T-cell: signaling defects and novel prospects for the treatment of SLE. Trends Immunol. 2003 May; 24(5):259-63.
    View in: PubMed
  202. Krishnan S, Warke VG, Nambiar MP, Tsokos GC, Farber DL. The FcR gamma subunit and Syk kinase replace the CD3 zeta-chain and ZAP-70 kinase in the TCR signaling complex of human effector CD4 T cells. J Immunol. 2003 Apr 15; 170(8):4189-95.
    View in: PubMed
  203. Tsokos GC, Nambiar MP, Juang YT. Activation of the Ets transcription factor Elf-1 requires phosphorylation and glycosylation: defective expression of activated Elf-1 is involved in the decreased TCR zeta chain gene expression in patients with systemic lupus erythematosus. Ann N Y Acad Sci. 2003 Apr; 987:240-5.
    View in: PubMed
  204. Tenbrock K, Juang YT, Tolnay M, Tsokos GC. The cyclic adenosine 5'-monophosphate response element modulator suppresses IL-2 production in stimulated T cells by a chromatin-dependent mechanism. J Immunol. 2003 Mar 15; 170(6):2971-6.
    View in: PubMed
  205. Nambiar MP, Fisher CU, Kumar A, Tsokos CG, Warke VG, Tsokos GC. Forced expression of the Fc receptor gamma-chain renders human T cells hyperresponsive to TCR/CD3 stimulation. J Immunol. 2003 Mar 15; 170(6):2871-6.
    View in: PubMed
  206. Warke VG, Nambiar MP, Krishnan S, Tenbrock K, Geller DA, Koritschoner NP, Atkins JL, Farber DL, Tsokos GC. Transcriptional activation of the human inducible nitric-oxide synthase promoter by Kruppel-like factor 6. J Biol Chem. 2003 Apr 25; 278(17):14812-9.
    View in: PubMed
  207. Fleming SD, Anderson J, Wilson F, Shea-Donohue T, Tsokos GC. C5 is required for CD49d expression on neutrophils and VCAM expression on vascular endothelial cells following mesenteric ischemia/reperfusion. Clin Immunol. 2003 Jan; 106(1):55-64.
    View in: PubMed
  208. Kyttaris V, Tsokos G. Uncovering the genetics of systemic lupus erythematosus: implications for therapy. Am J Pharmacogenomics. 2003; 3(3):193-202.
    View in: PubMed
  209. Nambiar MP, Mitchell JP, Ceruti RP, Malloy MA, Tsokos GC. Prevalence of T cell receptor zeta chain deficiency in systemic lupus erythematosus. Lupus. 2003; 12(1):46-51.
    View in: PubMed
  210. Khan IU, Tsokos GC, Kammer GM. Abnormal B cell signal transduction in systemic lupus erythematosus. Curr Dir Autoimmun. 2003; 6:89-104.
    View in: PubMed
  211. Tolnay M, Vereshchagina LA, Tsokos GC. NF-kappaB regulates the expression of the human complement receptor 2 gene. J Immunol. 2002 Dec 1; 169(11):6236-43.
    View in: PubMed
  212. Juang YT, Tenbrock K, Nambiar MP, Gourley MF, Tsokos GC. Defective production of functional 98-kDa form of Elf-1 is responsible for the decreased expression of TCR zeta-chain in patients with systemic lupus erythematosus. J Immunol. 2002 Nov 15; 169(10):6048-55.
    View in: PubMed
  213. Tenbrock K, Juang YT, Gourley MF, Nambiar MP, Tsokos GC. Antisense cyclic adenosine 5'-monophosphate response element modulator up-regulates IL-2 in T cells from patients with systemic lupus erythematosus. J Immunol. 2002 Oct 15; 169(8):4147-52.
    View in: PubMed
  214. Fleming SD, Shea-Donohue T, Guthridge JM, Kulik L, Waldschmidt TJ, Gipson MG, Tsokos GC, Holers VM. Mice deficient in complement receptors 1 and 2 lack a tissue injury-inducing subset of the natural antibody repertoire. J Immunol. 2002 Aug 15; 169(4):2126-33.
    View in: PubMed
  215. Tsokos GC. Lupus: immunity gone awry. Health News. 2002 Aug; 8(8):1-2.
    View in: PubMed
  216. Lawson S, Ward DT, Conner C, Gallagher C, Tsokos G, Shea-Donohue T. Diabetic hyperglycemia: a facilitating factor in systemic capillary leak. J Surg Res. 2002 Jun 15; 105(2):95-101.
    View in: PubMed
  217. Fleming SD, Starnes BW, Kiang JG, Stojadinovic A, Tsokos GC, Shea-Donohue T. Heat stress protection against mesenteric I/R-induced alterations in intestinal mucosa in rats. J Appl Physiol. 2002 Jun; 92(6):2600-7.
    View in: PubMed
  218. Kammer GM, Perl A, Richardson BC, Tsokos GC. Abnormal T cell signal transduction in systemic lupus erythematosus. Arthritis Rheum. 2002 May; 46(5):1139-54.
    View in: PubMed
  219. Herndon TM, Juang YT, Solomou EE, Rothwell SW, Gourley MF, Tsokos GC. Direct transfer of p65 into T lymphocytes from systemic lupus erythematosus patients leads to increased levels of interleukin-2 promoter activity. Clin Immunol. 2002 May; 103(2):145-53.
    View in: PubMed
  220. Tolnay M, Juang YT, Tsokos GC. Protein kinase A enhances, whereas glycogen synthase kinase-3 beta inhibits, the activity of the exon 2-encoded transactivator domain of heterogeneous nuclear ribonucleoprotein D in a hierarchical fashion. Biochem J. 2002 Apr 1; 363(Pt 1):127-36.
    View in: PubMed
  221. Juang YT, Solomou EE, Rellahan B, Tsokos GC. Phosphorylation and O-linked glycosylation of Elf-1 leads to its translocation to the nucleus and binding to the promoter of the TCR zeta-chain. J Immunol. 2002 Mar 15; 168(6):2865-71.
    View in: PubMed
  222. Gilliland WR, Tsokos GC. Prophylactic use of antibiotics and immunisations in patients with SLE. Ann Rheum Dis. 2002 Mar; 61(3):191-2.
    View in: PubMed
  223. Kiang JG, Kiang SC, Juang YT, Tsokos GC. N(omega)-nitro-L-arginine inhibits inducible HSP-70 via Ca(2+), PKC, and PKA in human intestinal epithelial T84 cells. Am J Physiol Gastrointest Liver Physiol. 2002 Mar; 282(3):G415-23.
    View in: PubMed
  224. Morikis D, Roy M, Sahu A, Troganis A, Jennings PA, Tsokos GC, Lambris JD. The structural basis of compstatin activity examined by structure-function-based design of peptide analogs and NMR. J Biol Chem. 2002 Apr 26; 277(17):14942-53.
    View in: PubMed
  225. Nambiar MP, Fisher CU, Enyedy EJ, Warke VG, Kumar A, Tsokos GC. Oxidative stress is involved in the heat stress-induced downregulation of TCR zeta chain expression and TCR/CD3-mediated [Ca(2+)](i) response in human T-lymphocytes. Cell Immunol. 2002 Feb; 215(2):151-61.
    View in: PubMed
  226. Nambiar MP, Enyedy EJ, Fisher CU, Krishnan S, Warke VG, Gilliland WR, Oglesby RJ, Tsokos GC. Abnormal expression of various molecular forms and distribution of T cell receptor zeta chain in patients with systemic lupus erythematosus. Arthritis Rheum. 2002 Jan; 46(1):163-74.
    View in: PubMed
  227. Kammer GM, Tsokos GC. Abnormal T lymphocyte signal transduction in systemic lupus erythematosus. Curr Dir Autoimmun. 2002; 5:131-50.
    View in: PubMed
  228. Nambiar MP, Juang YT, Tsokos GC. Emerging concepts in the molecular pathogenesis of systemic lupus erythematosus. Arch Immunol Ther Exp (Warsz). 2002; 50(1):35-45.
    View in: PubMed
  229. Mitchell JP, Enyedy EJ, Nambiar MP, Lees A, Tsokos GC. Engagement of complement receptor 2 on the surface of B cells from patients with systemic lupus erythematosus contributes to the increased responsiveness to antigen stimulation. Lupus. 2002; 11(5):299-303.
    View in: PubMed
  230. Nambiar MP, Warke VG, Fisher CU, Tsokos GC. Effect of trichostatin A on human T cells resembles signaling abnormalities in T cells of patients with systemic lupus erythematosus: a new mechanism for TCR zeta chain deficiency and abnormal signaling. J Cell Biochem. 2002; 85(3):459-69.
    View in: PubMed
  231. Tsokos GC. Systemic lupus erythematosus. A disease with a complex pathogenesis. Lancet. 2001 Dec; 358 Suppl:S65.
    View in: PubMed
  232. Gilliland WR, Tsokos GC. The clinical spectrum of anti-insulin receptor antibodies and autoimmune disease. J Clin Rheumatol. 2001 Dec; 7(6):361-2.
    View in: PubMed
  233. Rehrig S, Fleming SD, Anderson J, Guthridge JM, Rakstang J, McQueen CE, Holers VM, Tsokos GC, Shea-Donohue T. Complement inhibitor, complement receptor 1-related gene/protein y-Ig attenuates intestinal damage after the onset of mesenteric ischemia/reperfusion injury in mice. J Immunol. 2001 Nov 15; 167(10):5921-7.
    View in: PubMed
  234. Enyedy EJ, Mitchell JP, Nambiar MP, Tsokos GC. Defective FcgammaRIIb1 signaling contributes to enhanced calcium response in B cells from patients with systemic lupus erythematosus. Clin Immunol. 2001 Nov; 101(2):130-5.
    View in: PubMed
  235. Nambiar MP, Enyedy EJ, Fisher CU, Warke VG, Tsokos GC. High dose of dexamethasone upregulates TCR/CD3-induced calcium response independent of TCR zeta chain expression in human T lymphocytes. J Cell Biochem. 2001 Aug 21-Sep 5; 83(3):401-13.
    View in: PubMed
  236. Krishnan S, Warke VG, Nambiar MP, Wong HK, Tsokos GC, Farber DL. Generation and biochemical analysis of human effector CD4 T cells: alterations in tyrosine phosphorylation and loss of CD3zeta expression. Blood. 2001 Jun 15; 97(12):3851-9.
    View in: PubMed
  237. Nambiar MP, Enyedy EJ, Warke VG, Krishnan S, Dennis G, Wong HK, Kammer GM, Tsokos GC. T cell signaling abnormalities in systemic lupus erythematosus are associated with increased mutations/polymorphisms and splice variants of T cell receptor zeta chain messenger RNA. Arthritis Rheum. 2001 Jun; 44(6):1336-50.
    View in: PubMed
  238. Vereshchagina LA, Tolnay M, Tsokos GC. Multiple transcription factors regulate the inducible expression of the human complement receptor 2 promoter. J Immunol. 2001 May 15; 166(10):6156-63.
    View in: PubMed
  239. Herndon TM, Shan XC, Tsokos GC, Wange RL. ZAP-70 and SLP-76 regulate protein kinase C-theta and NF-kappa B activation in response to engagement of CD3 and CD28. J Immunol. 2001 May 1; 166(9):5654-64.
    View in: PubMed
  240. Enyedy EJ, Nambiar MP, Liossis SN, Dennis G, Kammer GM, Tsokos GC. Fc epsilon receptor type I gamma chain replaces the deficient T cell receptor zeta chain in T cells of patients with systemic lupus erythematosus. Arthritis Rheum. 2001 May; 44(5):1114-21.
    View in: PubMed
  241. Warke VG, Krishnan S, Nambiar MP, Farber DL, Tsokos GC, Wong HK. Identification of differentially expressed genes in human memory (CD45RO+) CD4+ T lymphocytes. Immunol Invest. 2001 May; 30(2):87-101.
    View in: PubMed
  242. Solomou EE, Juang YT, Tsokos GC. Protein kinase C-theta participates in the activation of cyclic AMP-responsive element-binding protein and its subsequent binding to the -180 site of the IL-2 promoter in normal human T lymphocytes. J Immunol. 2001 May 1; 166(9):5665-74.
    View in: PubMed
  243. Solomou EE, Juang YT, Gourley MF, Kammer GM, Tsokos GC. Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus. J Immunol. 2001 Mar 15; 166(6):4216-22.
    View in: PubMed
  244. Nambiar MP, Enyedy EJ, Warke VG, Krishnan S, Dennis G, Kammer GM, Tsokos GC. Polymorphisms/mutations of TCR-zeta-chain promoter and 3' untranslated region and selective expression of TCR zeta-chain with an alternatively spliced 3' untranslated region in patients with systemic lupus erythematosus. J Autoimmun. 2001 Mar; 16(2):133-42.
    View in: PubMed
  245. Nambiar MP, Enyedy EJ, Fisher CU, Warke VG, Juang YT, Tsokos GC. Dexamethasone modulates TCR zeta chain expression and antigen receptor-mediated early signaling events in human T lymphocytes. Cell Immunol. 2001 Feb 25; 208(1):62-71.
    View in: PubMed
  246. Tsokos GC, Kammer GM. Molecular aberrations in human systemic lupus erythematosus. Mol Med Today. 2000 Nov; 6(11):418-24.
    View in: PubMed
  247. Nambiar MP, Fisher CU, Enyedy EJ, Warke VG, Krishnan S, Tsokos GC. Heat stress downregulates TCR zeta chain expression in human T lymphocytes. J Cell Biochem. 2000 Sep 7; 79(3):416-26.
    View in: PubMed
  248. Mishra N, Khan IU, Tsokos GC, Kammer GM. Association of deficient type II protein kinase A activity with aberrant nuclear translocation of the RII beta subunit in systemic lupus erythematosus T lymphocytes. J Immunol. 2000 Sep 1; 165(5):2830-40.
    View in: PubMed
  249. Tsokos GC, Wong HK, Enyedy EJ, Nambiar MP. Immune cell signaling in lupus. Curr Opin Rheumatol. 2000 Sep; 12(5):355-63.
    View in: PubMed
  250. Tsokos GC, Nepom GT. Gene therapy in the treatment of autoimmune diseases. J Clin Invest. 2000 Jul; 106(2):181-3.
    View in: PubMed
  251. Tolnay M, Baranyi L, Tsokos GC. Heterogeneous nuclear ribonucleoprotein D0 contains transactivator and DNA-binding domains. Biochem J. 2000 May 15; 348 Pt 1:151-8.
    View in: PubMed
  252. Tolnay M, Tsokos GC. Serum regulates the expression of complement receptor 2 on human B cell lines. Immunopharmacol Immunotoxicol. 2000 May; 22(2):205-19.
    View in: PubMed
  253. Goeckeritz BE, Lees A, Vos Q, Tsokos GC, Kuhlbusch K, Mond JJ. Enhanced and sustained activation of human B cells by anti-immunoglobulin conjugated to the EBV glycoprotein gp350. Eur J Immunol. 2000 Mar; 30(3):969-73.
    View in: PubMed
  254. Burt RK, Brenner M, Burns W, Courier E, Firestein G, Hahn B, Heslop H, Link C, McFarland H, Roland M, Territo M, Tsokos G, Traynor A. Gene-marked autologous hematopoietic stem cell transplantation of autoimmune disease. J Clin Immunol. 2000 Jan; 20(1):1-9.
    View in: PubMed
  255. Kiang JG, Gist ID, Tsokos GC. Regulation of heat shock protein 72 kDa and 90 kDa in human breast cancer MDA-MB-231 cells. Mol Cell Biochem. 2000 Jan; 204(1-2):169-78.
    View in: PubMed
  256. Liossis SN, Tsokos GC. Molecular aspects in the pathogenesis of human systemic lupus erythematosus. Arch Immunol Ther Exp (Warsz). 2000; 48(1):11-9.
    View in: PubMed
  257. Smallridge RC, Gist ID, Tsokos GC, Kiang JG. Characterization of distinct heat shock- and thapsigargin-induced cytoprotective proteins in FRTL-5 thyroid cells. Thyroid. 1999 Oct; 9(10):1041-7.
    View in: PubMed
  258. Kovacs B, Liossis SN, Gist ID, Tsokos GC. Crosslinking of Fas/CD95 suppresses the CD3-mediated signaling events in Jurkat T cells by inhibiting the association of the T-cell receptor zeta chain with src-protein tyrosine kinases and ZAP70. Apoptosis. 1999 Oct; 4(5):327-34.
    View in: PubMed
  259. Kiang JG, Gist ID, Tsokos GC. Biochemical requirements for the expression of heat shock protein 72 kda in human breast cancer MCF-7 cells. Mol Cell Biochem. 1999 Sep; 199(1-2):179-88.
    View in: PubMed
  260. Wong HK, Kammer GM, Dennis G, Tsokos GC. Abnormal NF-kappa B activity in T lymphocytes from patients with systemic lupus erythematosus is associated with decreased p65-RelA protein expression. J Immunol. 1999 Aug 1; 163(3):1682-9.
    View in: PubMed
  261. Tolnay M, Vereshchagina LA, Tsokos GC. Heterogeneous nuclear ribonucleoprotein D0B is a sequence-specific DNA-binding protein. Biochem J. 1999 Mar 1; 338 ( Pt 2):417-25.
    View in: PubMed
  262. Tsokos GC, Liossis SN. Immune cell signaling defects in lupus: activation, anergy and death. Immunol Today. 1999 Mar; 20(3):119-24.
    View in: PubMed
  263. Eror AT, Stojadinovic A, Starnes BW, Makrides SC, Tsokos GC, Shea-Donohue T. Antiinflammatory effects of soluble complement receptor type 1 promote rapid recovery of ischemia/reperfusion injury in rat small intestine. Clin Immunol. 1999 Feb; 90(2):266-75.
    View in: PubMed
  264. Kiang JG, Ding XZ, Gist ID, Jones RR, Tsokos GC. Corticotropin-releasing factor induces phosphorylation of phospholipase C-gamma at tyrosine residues via its receptor 2beta in human epidermoid A-431 cells. Eur J Pharmacol. 1998 Dec 18; 363(2-3):203-10.
    View in: PubMed
  265. Kammer GM, Tsokos GC. Emerging concepts of the molecular basis for estrogen effects on T lymphocytes in systemic lupus erythematosus. Clin Immunol Immunopathol. 1998 Dec; 89(3):192-5.
    View in: PubMed
  266. Kiang JG, Tsokos GC. Heat shock protein 70 kDa: molecular biology, biochemistry, and physiology. Pharmacol Ther. 1998 Nov; 80(2):183-201.
    View in: PubMed
  267. Kiang JG, Gist ID, Tsokos GC. Cytoprotection and regulation of heat shock proteins induced by heat shock in human breast cancer T47-D cells: role of [Ca2+]i and protein kinases. FASEB J. 1998 Nov; 12(14):1571-9.
    View in: PubMed
  268. Tsokos GC, Liossis SN. Lymphocytes, cytokines, inflammation, and immune trafficking. Curr Opin Rheumatol. 1998 Sep; 10(5):417-25.
    View in: PubMed
  269. Liossis SN, Hoffman RW, Tsokos GC. Abnormal early TCR/CD3-mediated signaling events of a snRNP-autoreactive lupus T cell clone. Clin Immunol Immunopathol. 1998 Sep; 88(3):305-10.
    View in: PubMed
  270. Tolnay M, Tsokos GC. Complement receptor 2 in the regulation of the immune response. Clin Immunol Immunopathol. 1998 Aug; 88(2):123-32.
    View in: PubMed
  271. Liossis SN, Sfikakis PP, Tsokos GC. Immune cell signaling aberrations in human lupus. Immunol Res. 1998 Aug; 18(1):27-39.
    View in: PubMed
  272. Liossis SN, Tsokos GC. Cellular immunity in osteoarthritis: novel concepts for an old disease. Clin Diagn Lab Immunol. 1998 Jul; 5(4):427-9.
    View in: PubMed
  273. Ding XZ, Tsokos GC, Kiang JG. Overexpression of HSP-70 inhibits the phosphorylation of HSF1 by activating protein phosphatase and inhibiting protein kinase C activity. FASEB J. 1998 Apr; 12(6):451-9.
    View in: PubMed
  274. Liossis SN, Ding XZ, Dennis GJ, Tsokos GC. Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain. J Clin Invest. 1998 Apr 1; 101(7):1448-57.
    View in: PubMed
  275. Liossis SN, Via CS, Tsokos GC. The alter ego of heat shock proteins. Clin Immunol Immunopathol. 1998 Mar; 86(3):235-6.
    View in: PubMed
  276. Kiang JG, Gist ID, Tsokos GC. 17 beta-estradiol-induced increases in glucose-regulated protein 78kD and 94kD protect human breast cancer T47-D cells from thermal injury. Chin J Physiol. 1997 Dec 31; 40(4):213-9.
    View in: PubMed
  277. Tolnay M, Lambris JD, Tsokos GC. Transcriptional regulation of the complement receptor 2 gene: role of a heterogeneous nuclear ribonucleoprotein. J Immunol. 1997 Dec 1; 159(11):5492-501.
    View in: PubMed
  278. Liossis SN, Tsokos GC. Heat-shock of normal t-cells and T-cell lines downregulates the TCR/CD3-mediated cytoplasmic Ca2+ responses and the production of inositol trisphosphate. Immunopharmacol Immunotoxicol. 1997 Nov; 19(4):511-21.
    View in: PubMed
  279. Liossis SN, Vassilopoulos D, Kovacs B, Tsokos GC. Immune cell biochemical abnormalities in systemic lupus erythematosus. Clin Exp Rheumatol. 1997 Nov-Dec; 15(6):677-84.
    View in: PubMed
  280. Tsokos GC, Kovacs B, Liossis SN. Lymphocytes, cytokines, inflammation, and immune trafficking. Curr Opin Rheumatol. 1997 Sep; 9(5):380-6.
    View in: PubMed
  281. Smallridge RC, Tsokos GC, Burman KD, Porter L, Cranston T, Sfikakis PP, Solomon BL. Soluble interleukin-2 receptor is a thyroid hormone-dependent early-response marker in the treatment of thyrotoxicosis. Clin Diagn Lab Immunol. 1997 Sep; 4(5):583-6.
    View in: PubMed
  282. Liossis SN, Ding XZ, Kiang JG, Tsokos GC. Overexpression of the heat shock protein 70 enhances the TCR/CD3- and Fas/Apo-1/CD95-mediated apoptotic cell death in Jurkat T cells. J Immunol. 1997 Jun 15; 158(12):5668-75.
    View in: PubMed
  283. Vassilopoulos D, Zurier RB, Rossetti RG, Tsokos GC. Gammalinolenic acid and dihomogammalinolenic acid suppress the CD3-mediated signal transduction pathway in human T cells. Clin Immunol Immunopathol. 1997 Jun; 83(3):237-44.
    View in: PubMed
  284. Sfikakis PP, Tsokos GC. Clinical use of the measurement of soluble cell adhesion molecules in patients with autoimmune rheumatic diseases. Clin Diagn Lab Immunol. 1997 May; 4(3):241-6.
    View in: PubMed
  285. Kovacs B, Patel A, Hershey JN, Dennis GJ, Kirschfink M, Tsokos GC. Antibodies against p53 in sera from patients with systemic lupus erythematosus and other rheumatic diseases. Arthritis Rheum. 1997 May; 40(5):980-2.
    View in: PubMed
  286. Ding XZ, Tsokos GC, Smallridge RC, Kiang JG. Heat shock gene-expression in HSP-70 and HSF1 gene-transfected human epidermoid A-431 cells. Mol Cell Biochem. 1997 Feb; 167(1-2):145-52.
    View in: PubMed
  287. Kovacs B, Szentendrei T, Bednarek JM, Pierson MC, Mountz JD, Vogelgesang SA, Tsokos GC. Persistent expression of a soluble form of Fas/APO1 in continuously activated T cells from a patient with SLE. Clin Exp Rheumatol. 1997 Jan-Feb; 15(1):19-23.
    View in: PubMed
  288. Kovacs B, Liossis SN, Dennis GJ, Tsokos GC. Increased expression of functional Fas-ligand in activated T cells from patients with systemic lupus erythematosus. Autoimmunity. 1997; 25(4):213-21.
    View in: PubMed
  289. Ding XZ, Tsokos GC, Kiang JG. Heat shock factor-1 protein in heat shock factor-1 gene-transfected human epidermoid A431 cells requires phosphorylation before inducing heat shock protein-70 production. J Clin Invest. 1997 Jan 1; 99(1):136-43.
    View in: PubMed
  290. Kovacs B, Vassilopoulos D, Vogelgesang SA, Tsokos GC. Defective CD3-mediated cell death in activated T cells from patients with systemic lupus erythematosus: role of decreased intracellular TNF-alpha. Clin Immunol Immunopathol. 1996 Dec; 81(3):293-302.
    View in: PubMed
  291. Liossis SN, Kovacs B, Dennis G, Kammer GM, Tsokos GC. B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events. J Clin Invest. 1996 Dec 1; 98(11):2549-57.
    View in: PubMed
  292. Kovacs B, Thomas DE, Tsokos GC. Elevated in vivo expression of the costimulatory molecule B7-BB1 (CD80) on antigen presenting cells from a patient with SLE. Clin Exp Rheumatol. 1996 Nov-Dec; 14(6):695-7.
    View in: PubMed
  293. Tsokos GC. Lymphocytes, cytokines, inflammation, and immune trafficking. Curr Opin Rheumatol. 1996 Sep; 8(5):395-402.
    View in: PubMed
  294. Vogelgesang SA, Heyes MP, West SG, Salazar AM, Sfikakis PP, Lipnick RN, Klipple GL, Tsokos GC. Quinolinic acid in patients with systemic lupus erythematosus and neuropsychiatric manifestations. J Rheumatol. 1996 May; 23(5):850-5.
    View in: PubMed
  295. Hornstein EH, Vassilopoulos D, Thomas DE, Friedman FK, Tsokos GC. Modulation of human T-lymphocyte plasma membrane Ca2+ permeability by imidazole antimycotics. Immunopharmacol Immunotoxicol. 1996 May; 18(2):237-45.
    View in: PubMed
  296. Sfikakis PP, Souliotis VL, Katsilambros N, Markakis K, Vaiopoulos G, Tsokos GC, Panayiotidis P. Downregulation of interleukin-2 and apha-chain interleukin-2 receptor biosynthesis by cisplatin in human peripheral lymphocytes. Clin Immunol Immunopathol. 1996 Apr; 79(1):43-9.
    View in: PubMed
  297. Tsokos GC, Kovacs B, Sfikakis PP, Theocharis S, Vogelgesang S, Via CS. Defective antigen-presenting cell function in patients with systemic lupus erythematosus. Arthritis Rheum. 1996 Apr; 39(4):600-9.
    View in: PubMed
  298. Iliopoulos AG, Tsokos GC. Immunopathogenesis and spectrum of infections in systemic lupus erythematosus. Semin Arthritis Rheum. 1996 Apr; 25(5):318-36.
    View in: PubMed
  299. Lipnick RN, Iliopoulos A, Salata K, Hershey J, Melnick D, Tsokos GC. Leukocyte adhesion deficiency: report of a case and review of the literature. Clin Exp Rheumatol. 1996 Jan-Feb; 14(1):95-8.
    View in: PubMed
  300. Kovacs B, Tsokos GC. Cross-linking of the Fas/APO-1 antigen suppresses the CD3-mediated signal transduction events in human T lymphocytes. J Immunol. 1995 Dec 15; 155(12):5543-9.
    View in: PubMed
  301. Sfikakis PP, Tsokos GC. Lymphocyte adhesion molecules in autoimmune rheumatic diseases: basic issues and clinical expectations. Clin Exp Rheumatol. 1995 Nov-Dec; 13(6):763-77.
    View in: PubMed
  302. Vassilopoulos D, Smallridge RC, Tsokos GC. Effects of an aminosteroid inhibitor of phospholipase C-dependent processes on the TCR-mediated signal transduction pathway in human T cells. Clin Immunol Immunopathol. 1995 Oct; 77(1):59-68.
    View in: PubMed
  303. Tsokos GC. Lymphocytes, cytokines, inflammation, and immune trafficking. Curr Opin Rheumatol. 1995 Sep; 7(5):376-83.
    View in: PubMed
  304. Vassilopoulos D, Kovacs B, Tsokos GC. TCR/CD3 complex-mediated signal transduction pathway in T cells and T cell lines from patients with systemic lupus erythematosus. J Immunol. 1995 Aug 15; 155(4):2269-81.
    View in: PubMed
  305. Sfikakis PP, Zografou A, Viglis V, Iniotaki-Theodoraki A, Piskontaki I, Tsokos GC, Sfikakis P, Choremi-Papadopoulou H. CD28 expression on T cell subsets in vivo and CD28-mediated T cell response in vitro in patients with rheumatoid arthritis. Arthritis Rheum. 1995 May; 38(5):649-54.
    View in: PubMed
  306. Theocharis S, Sfikakis PP, Lipnick RN, Klipple GL, Steinberg AD, Tsokos GC. Characterization of in vivo mutated T cell clones from patients with systemic lupus erythematosus. Clin Immunol Immunopathol. 1995 Feb; 74(2):135-42.
    View in: PubMed
  307. Vaiopoulos G, Sfikakis PP, Kapsimali V, Boki K, Panayiotidis P, Aessopos A, Tsokos GC, Kaklamanis P. The association of systemic lupus erythematosus and myasthenia gravis. Postgrad Med J. 1994 Oct; 70(828):741-5.
    View in: PubMed
  308. Tsokos GC. Lymphocytes, cytokines, inflammation, and immune trafficking. Curr Opin Rheumatol. 1994 Sep; 6(5):461-7.
    View in: PubMed
  309. Sfikakis PP, Oglesby R, Sfikakis P, Tsokos GC. B7/BB1 provides an important costimulatory signal for CD3-mediated T lymphocyte proliferation in patients with systemic lupus erythematosus (SLE). Clin Exp Immunol. 1994 Apr; 96(1):8-14.
    View in: PubMed
  310. Sfikakis PP, Tesar J, Theocharis S, Klipple GL, Tsokos GC. Increased frequency of in vivo hprt gene-mutated T cells in the peripheral blood of patients with systemic sclerosis. Ann Rheum Dis. 1994 Feb; 53(2):122-7.
    View in: PubMed
  311. Sfikakis PP, Tsokos GC. Increased levels of intercellular adhesion molecule 1 in patients with systemic lupus erythematosus: comment on the article by Mason et al. Arthritis Rheum. 1994 Feb; 37(2):300-1.
    View in: PubMed
  312. Sfikakis PP, Charalambopoulos D, Vayiopoulos G, Oglesby R, Sfikakis P, Tsokos GC. Increased levels of intercellular adhesion molecule-1 in the serum of patients with systemic lupus erythematosus. Clin Exp Rheumatol. 1994 Jan-Feb; 12(1):5-9.
    View in: PubMed
  313. Sfikakis PP, McCune BK, Tsokos M, Aroni K, Vayiopoulos G, Tsokos GC. Immunohistological demonstration of transforming growth factor-beta isoforms in the skin of patients with systemic sclerosis. Clin Immunol Immunopathol. 1993 Nov; 69(2):199-204.
    View in: PubMed
  314. Via CS, Tsokos GC, Bermas B, Clerici M, Shearer GM. T cell-antigen-presenting cell interactions in human systemic lupus erythematosus. Evidence for heterogeneous expression of multiple defects. J Immunol. 1993 Oct 1; 151(7):3914-22.
    View in: PubMed
  315. Lipnick RN, Sfikakis PP, Klipple GL, Tsokos GC. Elevated soluble CD8 antigen and soluble interleukin-2 receptors in the sera of patients with juvenile rheumatoid arthritis. Clin Immunol Immunopathol. 1993 Jul; 68(1):64-7.
    View in: PubMed
  316. Sfikakis PP, Tesar J, Baraf H, Lipnick R, Klipple G, Tsokos GC. Circulating intercellular adhesion molecule-1 in patients with systemic sclerosis. Clin Immunol Immunopathol. 1993 Jul; 68(1):88-92.
    View in: PubMed
  317. Victor KD, Pascual V, Stitzel AE, Tsokos GC, Capra JD, Spitzer RE. Nucleotide sequence of a human autoantibody to the alternative pathway C3/C5 convertase (C3NeF). Hybridoma. 1993 Jun; 12(3):231-7.
    View in: PubMed
  318. Goust JM, Tsokos G. Systemic lupus erythematosus. Immunol Ser. 1993; 58:437-49.
    View in: PubMed
  319. Goust JM, Tsokos G, Virella G. Tolerance and autoimmunity. Immunol Ser. 1993; 58:397-421.
    View in: PubMed
  320. Spitzer RE, Stitzel AE, Tsokos G. On the origin of C3 nephritic factor (antibody to the alternative pathway C3 convertase): evidence for the Adam and Eve concept of autoantibody production. Clin Immunol Immunopathol. 1992 Sep; 64(3):177-83.
    View in: PubMed
  321. Baxevanis CN, Thanos D, Reclos GJ, Anastasopoulos E, Tsokos GC, Papamatheakis J, Papamichail M. Prothymosin alpha enhances human and murine MHC class II surface antigen expression and messenger RNA accumulation. J Immunol. 1992 Apr 1; 148(7):1979-84.
    View in: PubMed
  322. Tsokos GC. Pathogenesis of human systemic lupus erythematosus. Introduction. Clin Immunol Immunopathol. 1992 Apr; 63(1):3.
    View in: PubMed
  323. Tsokos GC. Lymphocyte abnormalities in human lupus. Clin Immunol Immunopathol. 1992 Apr; 63(1):7-9.
    View in: PubMed
  324. Spitzer RE, Stitzel AE, Tsokos GC. Study of the idiotypic response to autoantibody to the alternative pathway C3/C5 convertase in normal individuals, patients with membranoproliferative glomerulonephritis, and experimental animals. Clin Immunol Immunopathol. 1992 Mar; 62(3):291-4.
    View in: PubMed
  325. Anastassiou ED, Yamada H, Boumpas DT, Tsokos GC, Thyphronitis G, Balow J, Mond JJ. Cholera toxin promotes the proliferation of anti-mu antibody-prestimulated human B cells. Cell Immunol. 1992 Mar; 140(1):237-47.
    View in: PubMed
  326. Spitzer RE, Stitzel AE, Tsokos GC. Autoantibody to the alternative pathway C3/C5 convertase and its anti-idiotypic response. A study in affinity. J Immunol. 1992 Jan 1; 148(1):137-41.
    View in: PubMed
  327. Lipnick RN, Tsokos GC, Magilavy DB. Immune abnormalities in the pathogenesis of juvenile rheumatoid arthritis. Rheum Dis Clin North Am. 1991 Nov; 17(4):843-57.
    View in: PubMed
  328. Steinberg AD, Gourley MF, Klinman DM, Tsokos GC, Scott DE, Krieg AM. NIH conference. Systemic lupus erythematosus. Ann Intern Med. 1991 Oct 1; 115(7):548-59.
    View in: PubMed
  329. Tsokos GC. Biochemical and molecular abnormalities in the pathogenesis of systemic lupus erythematosus. Clin Exp Rheumatol. 1991 Sep-Oct; 9(5):533-9.
    View in: PubMed
  330. Thyphronitis G, Kinoshita T, Inoue K, Schweinle JE, Tsokos GC, Metcalf ES, Finkelman FD, Balow JE. Modulation of mouse complement receptors 1 and 2 suppresses antibody responses in vivo. J Immunol. 1991 Jul 1; 147(1):224-30.
    View in: PubMed
  331. Boumpas DT, Anastassiou ED, Older SA, Tsokos GC, Nelson DL, Balow JE. Dexamethasone inhibits human interleukin 2 but not interleukin 2 receptor gene expression in vitro at the level of nuclear transcription. J Clin Invest. 1991 May; 87(5):1739-47.
    View in: PubMed
  332. Thyphronitis G, Banchereau J, Heusser C, Tsokos GC, Levine AD, Finkelman FD. Kinetics of interleukin-4 induction and interferon-gamma inhibition of IgE secretion by Epstein-Barr virus-infected human peripheral blood B cells. Cell Immunol. 1991 Apr 1; 133(2):408-19.
    View in: PubMed
  333. Kaklamanis P, Vayopoulos G, Stamatelos G, Dadinas G, Tsokos GC. Chronic lupus peritonitis with ascites. Ann Rheum Dis. 1991 Mar; 50(3):176-7.
    View in: PubMed
  334. Linos A, Kaklamanis E, Kontomerkos A, Koumantaki Y, Gazi S, Vaiopoulos G, Tsokos GC, Kaklamanis P. The effect of olive oil and fish consumption on rheumatoid arthritis--a case control study. Scand J Rheumatol. 1991; 20(6):419-26.
    View in: PubMed
  335. Boumpas DT, Anastassiou ED, Tsokos GC, Thyphronitis G, Balow JE. Gene transcription during in vitro activation of human B lymphocytes with Staphylococcus aureus Cowan I strain. J Immunol. 1990 Oct 15; 145(8):2701-5.
    View in: PubMed
  336. Anastassiou ED, Yamada H, Francis ML, Mond JJ, Tsokos GC. Effects of cholera toxin on human B cells. Cholera toxin induces B cell surface DR expression while it inhibits anti-mu antibody-induced cell proliferation. J Immunol. 1990 Oct 15; 145(8):2375-80.
    View in: PubMed
  337. Spitzer RE, Stitzel AE, Tsokos GC. Human anti-idiotypic antibody responses to autoantibody against the alternative pathway C3 convertase. Clin Immunol Immunopathol. 1990 Oct; 57(1):19-31.
    View in: PubMed
  338. Spitzer RE, Stitzel AE, Tsokos GC. Production of IgG and IgM autoantibody to the alternative pathway C3 convertase in normal individuals and patients with membranoproliferative glomerulonephritis. Clin Immunol Immunopathol. 1990 Oct; 57(1):10-8.
    View in: PubMed
  339. Rajagopalan S, Zordan T, Tsokos GC, Datta SK. Pathogenic anti-DNA autoantibody-inducing T helper cell lines from patients with active lupus nephritis: isolation of CD4-8- T helper cell lines that express the gamma delta T-cell antigen receptor. Proc Natl Acad Sci U S A. 1990 Sep; 87(18):7020-4.
    View in: PubMed
  340. Spitzer RE, Stitzel AE, Tsokos GC. Evidence that production of autoantibody to the alternative pathway C3 convertase is a normal physiologic event. J Pediatr. 1990 May; 116(5):S103-8.
    View in: PubMed
  341. Lipnick RN, Tsokos GC, Bray GL, White PH. Autoimmune thrombocytopenia in pediatric systemic lupus erythematosus: alternative therapeutic modalities. Clin Exp Rheumatol. 1990 May-Jun; 8(3):315-9.
    View in: PubMed
  342. Via CS, Tsokos GC, Stocks NI, Clerici M, Shearer GM. Human in vitro allogeneic responses. Demonstration of three pathways of T helper cell activation. J Immunol. 1990 Apr 1; 144(7):2524-8.
    View in: PubMed
  343. Lipnick RN, Tsokos GC. Immune abnormalities in the pathogenesis of juvenile rheumatoid arthritis. Clin Exp Rheumatol. 1990 Mar-Apr; 8(2):177-86.
    View in: PubMed
  344. Tsokos GC, Lambris JD, Finkelman FD, Anastassiou ED, June CH. Monovalent ligands of complement receptor 2 inhibit whereas polyvalent ligands enhance anti-Ig-induced human B cell intracytoplasmic free calcium concentration. J Immunol. 1990 Mar 1; 144(5):1640-5.
    View in: PubMed
  345. Pillemer SR, Tsokos GC, Barbieri SA, Balow JE, Golding B. The CR2 receptor (CD21) shows increased expression in the more differentiated cells of an antigen-specific B cell line. Cell Immunol. 1990 Feb; 125(2):386-95.
    View in: PubMed
  346. Boumpas DT, Eleftheriades EG, Molina R, Barez S, Atkinson J, Older SA, Balow JE, Tsokos GC. c-myc proto-oncogene expression in peripheral blood mononuclear cells from patients with primary Sjögren's syndrome. Arthritis Rheum. 1990 Jan; 33(1):49-56.
    View in: PubMed
  347. Tsokos GC, Kinoshita T, Thyphronitis G, Patel AD, Dickler HB, Finkelman FD. Interactions between murine B lymphocyte surface membrane molecules. Loaded but not free receptors for complement and the Fc portion of IgG co-cap independently with cross-linked surface Ig. J Immunol. 1990 Jan 1; 144(1):239-43.
    View in: PubMed
  348. Kinoshita T, Thyphronitis G, Tsokos GC, Finkelman FD, Hong K, Sakai H, Inoue K. Characterization of murine complement receptor type 2 and its immunological cross-reactivity with type 1 receptor. Int Immunol. 1990; 2(7):651-9.
    View in: PubMed
  349. Tsokos GC, Stitzel AE, Patel AD, Hiramatsu M, Balow JE, Spitzer RE. Human polyclonal and monoclonal IgG and IgM complement 3 nephritic factors: evidence for idiotypic commonality. Clin Immunol Immunopathol. 1989 Oct; 53(1):113-22.
    View in: PubMed
  350. Eleftheriades EG, Boumpas DT, Balow JE, Tsokos GC. Transcriptional and post-transcriptional mechanisms are responsible for the increased expression of c-myc protooncogene in lymphocytes from patients with systemic lupus erythematosus. Clin Immunol Immunopathol. 1989 Sep; 52(3):507-15.
    View in: PubMed
  351. Cronin ME, Balow JE, Tsokos GC. Immunoglobulin deficiency in patients with systemic lupus erythematosus. Clin Exp Rheumatol. 1989 Jul-Aug; 7(4):359-64.
    View in: PubMed
  352. Shivakumar S, Tsokos GC, Datta SK. T cell receptor alpha/beta expressing double-negative (CD4-/CD8-) and CD4+ T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritis. J Immunol. 1989 Jul 1; 143(1):103-12.
    View in: PubMed
  353. Thyphronitis G, Tsokos GC, June CH, Levine AD, Finkelman FD. IgE secretion by Epstein-Barr virus-infected purified human B lymphocytes is stimulated by interleukin 4 and suppressed by interferon gamma. Proc Natl Acad Sci U S A. 1989 Jul; 86(14):5580-4.
    View in: PubMed
  354. Golding B, Pillemer SR, Roussou P, Peters EA, Tsokos GC, Ballow JE, Hoffman T. Inverse relationship between proliferation and differentiation in a human TNP-specific B cell line. Cell cycle dependence of antibody secretion. J Immunol. 1988 Oct 15; 141(8):2564-8.
    View in: PubMed
  355. Boumpas DT, Eleftheriades EG, Barez S, Tsokos GC. Oncogene expression and regulation in normal lymphocytes and lymphocytes from patients with autoimmune diseases. Anticancer Res. 1988 Sep-Oct; 8(5A):977-84.
    View in: PubMed
  356. Tsokos GC, Thyphronitis G, Jack RM, Finkelman FD. Ligand-loaded but not free complement receptors for C3b/C4b and C3d co-cap with cross-linked B cell surface IgM and IgD. J Immunol. 1988 Aug 15; 141(4):1261-6.
    View in: PubMed
  357. Inghirami G, Simon J, Balow JE, Tsokos GC. Activated T lymphocytes in the peripheral blood of patients with systemic lupus erythematosus induce B cells to produce immunoglobulin. Clin Exp Rheumatol. 1988 Jul-Sep; 6(3):269-76.
    View in: PubMed
  358. Tsokos GC, Inghirami G, Pillemer SR, Mavridis A, Magilavy DB. Immunoregulatory aberrations in patients with polyarticular juvenile rheumatoid arthritis. Clin Immunol Immunopathol. 1988 Apr; 47(1):62-74.
    View in: PubMed
  359. Pillemer SR, Austin HA, Tsokos GC, Balow JE. Lupus nephritis: association between serology and renal biopsy measures. J Rheumatol. 1988 Feb; 15(2):284-8.
    View in: PubMed
  360. Boumpas DT, Eleftheriades EG, Tsokos GC. Cellular immunity in systemic lupus erythematosus. In Vivo. 1988 Jan-Feb; 2(1):41-5.
    View in: PubMed
  361. Joffe RT, Wolkowitz OM, Rubinow DR, Denicoff K, Tsokos G, Pillemer S. Alternate-day corticosteroid treatment, mood and plasma HVA in patients with systemic lupus erythematosus. Neuropsychobiology. 1988; 19(1):17-9.
    View in: PubMed
  362. Joffe RT, Denicoff KD, Rubinow DR, Tsokos G, Balow JE, Pillemer SE. Mood effects of alternate-day corticosteroid therapy in patients with systemic lupus erythematosus. Gen Hosp Psychiatry. 1988 Jan; 10(1):56-60.
    View in: PubMed
  363. Hiramatsu M, Tsokos GC. A factor activating complement via the alternative pathway in the supernatants of B cell lines transformed by Epstein-Barr virus and in sera obtained from patients with systemic lupus erythematosus. Int Arch Allergy Appl Immunol. 1988; 86(2):209-14.
    View in: PubMed
  364. Hiramatsu M, Tsokos GC. Epstein-Barr virus transformed B cell lines derived from patients with systemic lupus erythematosus produce a nephritic factor of the classical complement pathway. Clin Immunol Immunopathol. 1988 Jan; 46(1):91-9.
    View in: PubMed
  365. Golding B, Inghirami G, Peters E, Hoffman T, Balow JE, Tsokos GC. In vitro generated human monoclonal trinitrophenyl-specific B cell lines. Evidence that human and murine anti-trinitrophenyl monoclonal antibodies cross-react with Escherichia coli beta-galactosidase. J Immunol. 1987 Dec 15; 139(12):4061-6.
    View in: PubMed
  366. Reclos GJ, Baxevanis CN, Sfagos C, Papageorgiou C, Tsokos GC, Papamichail M. Multiple sclerosis: II. Effects of prothymosin alpha on the autologous and allogeneic MLR in patients with multiple sclerosis. Clin Exp Immunol. 1987 Nov; 70(2):336-44.
    View in: PubMed
  367. Tsokos GC. Immunomodulatory treatment in patients with rheumatic diseases: mechanisms of action. Semin Arthritis Rheum. 1987 Aug; 17(1):24-38.
    View in: PubMed
  368. Avgerinos PC, Cutler GB, Tsokos GC, Gold PW, Feuillan P, Gallucci WT, Pillemer SR, Loriaux DL, Chrousos GP. Dissociation between cortisol and adrenal androgen secretion in patients receiving alternate day prednisone therapy. J Clin Endocrinol Metab. 1987 Jul; 65(1):24-9.
    View in: PubMed
  369. Tsokos GC, Pillemer SR, Klippel JH. Rheumatic disease syndromes associated with antibodies to the Ro (SS-A) ribonuclear protein. Semin Arthritis Rheum. 1987 May; 16(4):237-44.
    View in: PubMed
  370. Tsokos GC, Mavridis A, Inghirami G, Pillemer SR, Emery HM, Magilavy DB. Cellular immunity in patients with systemic juvenile rheumatoid arthritis. Clin Immunol Immunopathol. 1987 Jan; 42(1):86-92.
    View in: PubMed
  371. Baxevanis CN, Reclos GJ, Papamichail M, Tsokos GC. Prothymosin alpha restores the depressed autologous and allogeneic mixed lymphocyte responses in patients with systemic lupus erythematosus. Immunopharmacol Immunotoxicol. 1987; 9(4):429-40.
    View in: PubMed
  372. Balow JE, Austin HA, Tsokos GC, Antonovych TT, Steinberg AD, Klippel JH. NIH conference. Lupus nephritis. Ann Intern Med. 1987 Jan; 106(1):79-94.
    View in: PubMed
  373. Tsokos GC, Smith PL, Balow JE. Development of hypogammaglobulinemia in a patient with systemic lupus erythematosus. Am J Med. 1986 Dec; 81(6):1081-4.
    View in: PubMed
  374. Tsokos GC, Boumpas DT, Smith PL, Djeu JY, Balow JE, Rook AH. Deficient gamma-interferon production in patients with systemic lupus erythematosus. Arthritis Rheum. 1986 Oct; 29(10):1210-5.
    View in: PubMed
  375. Tsokos GC. Defective regulation of Epstein-Barr virus infection in patients with AIDS or AIDS-related disorders. N Engl J Med. 1986 Sep 18; 315(12):761-2.
    View in: PubMed
  376. Djeu JY, Kasahara T, Balow JE, Tsokos GC. Decreased interleukin 2 inhibitor in sera of patients with autoimmune disorders. Clin Exp Immunol. 1986 Aug; 65(2):279-85.
    View in: PubMed
  377. Tsokos GC, Tsokos M, le Riche NG, Klippel JH. A clinical and pathologic study of cerebrovascular disease in patients with systemic lupus erythematosus. Semin Arthritis Rheum. 1986 Aug; 16(1):70-8.
    View in: PubMed
  378. Golding B, Tsokos GC, Fleisher T, Muchmore AV, Blaese RM. The role of nonactivated and interferon-gamma activated monocytes in regulating normal and SLE patient B cell responses to TNP-Brucella abortus. J Immunol. 1986 Jul 1; 137(1):103-7.
    View in: PubMed
  379. Hiramatsu M, Balow JE, Tsokos GC. Production of nephritic factor of the alternative complement pathway by Epstein Barr virus-transformed B cell lines derived from a patient with membranoproliferative glomerulonephritis. J Immunol. 1986 Jun 15; 136(12):4451-5.
    View in: PubMed
  380. Boumpas DT, Tsokos GC, Mann DL, Eleftheriades EG, Harris CC, Mark GE. Increased proto-oncogene expression in peripheral blood lymphocytes from patients with systemic lupus erythematosus and other autoimmune diseases. Arthritis Rheum. 1986 Jun; 29(6):755-60.
    View in: PubMed
  381. Brickman CM, Tsokos GC, Balow JE, Lawley TJ, Santaella M, Hammer CH, Frank MM. Immunoregulatory disorders associated with hereditary angioedema. I. Clinical manifestations of autoimmune disease. J Allergy Clin Immunol. 1986 May; 77(5):749-57.
    View in: PubMed
  382. Brickman CM, Tsokos GC, Chused TM, Balow JE, Lawley TJ, Santaella M, Hammer CH, Linton GF, Frank MM. Immunoregulatory disorders associated with hereditary angioedema. II. Serologic and cellular abnormalities. J Allergy Clin Immunol. 1986 May; 77(5):758-67.
    View in: PubMed
  383. Lambris JD, Tsokos GC. The biology and pathophysiology of complement receptors. Anticancer Res. 1986 May-Jun; 6(3 Pt B):515-23.
    View in: PubMed
  384. Boumpas DT, Mark GE, Tsokos GC. Oncogenes and autoimmunity. Anticancer Res. 1986 May-Jun; 6(3 Pt B):491-7.
    View in: PubMed
  385. Boumpas DT, Popovic M, Mann DL, Balow JE, Tsokos GC. Type C retroviruses of the human T cell leukemia family are not evident in patients with systemic lupus erythematosus. Arthritis Rheum. 1986 Feb; 29(2):185-8.
    View in: PubMed
  386. Inghirami G, Lambris JD, Tsokos GC. Complement receptors (CR) and cytotoxic responses: monoclonal antibodies directed against CR1 and CR3 inhibit the generation of human allospecific and virus specific cytotoxic cells in vitro. J Immunopharmacol. 1986; 8(1):75-88.
    View in: PubMed
  387. Tsokos GC, Inghirami G, Lambris JD. Regulation of human cytotoxic responses by complement: C3, C3b and C3d preparations enhance human allogeneic cytotoxic responses. J Immunopharmacol. 1986; 8(4):529-41.
    View in: PubMed
  388. Aguado MT, Lambris JD, Tsokos GC, Burger R, Bitter-Suermann D, Tamerius JD, Dixon FJ, Theofilopoulos AN. Monoclonal antibodies against complement 3 neoantigens for detection of immune complexes and complement activation. Relationship between immune complex levels, state of C3, and numbers of receptors for C3b. J Clin Invest. 1985 Oct; 76(4):1418-26.
    View in: PubMed
  389. Tsokos GC, Caughman SW, Klippel JH. Successful treatment of generalized discoid skin lesions with azathioprine. Its use in a patient with systemic lupus erythematosus. Arch Dermatol. 1985 Oct; 121(10):1323-5.
    View in: PubMed
  390. Boumpas DT, Hooks JJ, Popovic M, Tsokos GC, Mann DL. Human T-cell leukemia/lymphoma virus I and/or Epstein-Barr virus-infected B-cell lines spontaneously produce acid-labile alpha-interferon. J Clin Immunol. 1985 Sep; 5(5):340-4.
    View in: PubMed
  391. Tsokos GC, Inghirami G, Tsoukas CD, Balow JE, Lambris JD. Regulation of immunoglobulin secretion by factor H of human complement. Immunology. 1985 Jul; 55(3):419-26.
    View in: PubMed
  392. Schürmeyer TH, Tsokos GC, Avgerinos PC, Balow JE, D'Agata R, Loriaux DL, Chrousos GP. Pituitary-adrenal responsiveness to corticotropin-releasing hormone in patients receiving chronic, alternate day glucocorticoid therapy. J Clin Endocrinol Metab. 1985 Jul; 61(1):22-7.
    View in: PubMed
  393. Song BJ, Gelboin HV, Park SS, Tsokos GC, Friedman FK. Monoclonal antibody-directed radioimmunoassay detects cytochrome P-450 in human placenta and lymphocytes. Science. 1985 Apr 26; 228(4698):490-2.
    View in: PubMed
  394. Tsokos GC, Smith PL, Christian CB, Lipnick RN, Balow JE, Djeu JY. Interleukin-2 restores the depressed allogeneic cell-mediated lympholysis and natural killer cell activity in patients with systemic lupus erythematosus. Clin Immunol Immunopathol. 1985 Mar; 34(3):379-86.
    View in: PubMed
  395. Tsokos GC, Gorden P, Antonovych T, Wilson CB, Balow JE. Lupus nephritis and other autoimmune features in patients with diabetes mellitus due to autoantibody to insulin receptors. Ann Intern Med. 1985 Feb; 102(2):176-81.
    View in: PubMed
  396. Boumpas DT, Tsokos GC. Pathophysiologic aspects of lymphokines. Clin Immunol Rev. 1985; 4(2):201-40.
    View in: PubMed
  397. Tsokos GC, Balow JE. Immunosuppressive agents and plasmapheresis in immunological disorders. J Immunopharmacol. 1985; 7(1):1-15.
    View in: PubMed
  398. Inghirami G, Djeu JY, Balow JE, Tsokos GC. Enhancement of human allogeneic cytotoxic responses by interferons. J Immunopharmacol. 1985; 7(4):403-15.
    View in: PubMed
  399. Lipnick RN, Balow JE, Tsokos GC. Lymphocyte subpopulations in patients with systemic lupus erythematosus. Clin Immunol Immunopathol. 1984 May; 31(2):181-90.
    View in: PubMed
  400. Tsokos GC, Berger M, Balow JE. Modulation of human B cell immunoglobulin secretion by the C3b component of complement. J Immunol. 1984 Feb; 132(2):622-6.
    View in: PubMed
  401. Balow JE, Tsokos GC. T and B lymphocyte function in patients with lupus nephritis: correlation with renal pathology. Clin Nephrol. 1984 Feb; 21(2):93-7.
    View in: PubMed
  402. Balow JE, Austin HA, Tsokos GC. Plasmapheresis therapy in immunologically mediated rheumatic and renal diseases. Clin Immunol Rev. 1984; 3(2):235-72.
    View in: PubMed
  403. Tsokos GC, Balow JE. Cellular immune responses in systemic lupus erythematosus. Prog Allergy. 1984; 35:93-161.
    View in: PubMed
  404. Tsokos GC, Magrath IT, Balow JE. Epstein-Barr virus induces normal B cell responses but defective suppressor T cell responses in patients with systemic lupus erythematosus. J Immunol. 1983 Oct; 131(4):1797-801.
    View in: PubMed
  405. Tsokos GC, Christian CB, Balow JE. Induction of monocytic suppression after stimulation of peripheral human mononuclear cells with staphylococcal protein A and Staphylococcus aureus. Cell Immunol. 1983 May; 78(1):144-51.
    View in: PubMed
  406. Tsokos GC, Balow JE. Phenotypes of T lymphocytes in systemic lupus erythematosus: decreased cytotoxic/suppressor subpopulation is associated with deficient allogeneic cytotoxic responses rather than with concanavalin A-induced suppressor cells. Clin Immunol Immunopathol. 1983 Feb; 26(2):267-76.
    View in: PubMed
  407. Tsokos GC, Rook AH, Djeu JY, Balow JE. Natural killer cells and interferon responses in patients with systemic lupus erythematosus. Clin Exp Immunol. 1982 Nov; 50(2):239-45.
    View in: PubMed
  408. Balow JE, Tsokos GC. Plasmapheresis in systemic lupus erythematosus: facts and perspectives. Int J Artif Organs. 1982 Sep; 5(5):286-9.
    View in: PubMed
  409. Tsokos GC, Christian CB, Balow JE. Concanavalin-induced suppressor cells: characterization on the basis of corticosteroid and radiation sensitivity. Immunology. 1982 Sep; 47(1):85-90.
    View in: PubMed
  410. Rook AH, Tsokos GC, Quinnan GV, Balow JE, Ramsey KM, Stocks N, Phelan MA, Djeu JY. Cytotoxic antibodies to natural killer cells in systemic lupus erythematosus. Clin Immunol Immunopathol. 1982 Aug; 24(2):179-85.
    View in: PubMed
  411. Tsokos GC, Balow JE. Suppressor T cells in systemic lupus erythematosus: lack of defective in vitro suppressor cell generation in patients with active disease. J Clin Lab Immunol. 1982 Jun; 8(2):83-90.
    View in: PubMed
  412. Tsokos GC, Balow JE, Huston DP, Wei N, Decker JL. Effect of plasmapheresis on T anc B lymphocyte functions in patients with systemic lupus erythematosus: a double blind study. Clin Exp Immunol. 1982 May; 48(2):449-57.
    View in: PubMed
  413. Demetrakopoulos GE, Tsokos GC, Levine AS. Recovery of splenic function after GVHD-associated functional asplenia. Am J Hematol. 1982 Feb; 12(1):77-80.
    View in: PubMed
  414. Tsokos GC, Balow JE. Spontaneous and pokeweed mitogen-induced plaque-forming cells in systemic lupus erythematosus. Clin Immunol Immunopathol. 1981 Nov; 21(2):172-83.
    View in: PubMed
  415. Tsokos GC, Balow JE. Cytotoxic responses to alloantigens in systemic lupus erythematosus. J Clin Immunol. 1981 Oct; 1(4):208-16.
    View in: PubMed
  416. Wei N, Pavlidis N, Tsokos G, Elin RJ, Plotz PH. Clinical significance of low creatine phosphokinase values in patients with connective tissue diseases. JAMA. 1981 Oct 23-30; 246(17):1921-3.
    View in: PubMed
  417. Tsokos GC, Moutsopoulos HM, Steinberg AD. Muscle involvement in systemic lupus erythematosus. JAMA. 1981 Aug 14; 246(7):766-8.
    View in: PubMed
  418. Tsokos GC, Balow JE, Spiegel RJ, Magrath IT. Renal and metabolic complications of undifferentiated and lymphoblastic lymphomas. Medicine (Baltimore). 1981 May; 60(3):218-29.
    View in: PubMed
  419. Tsokos GC, Choie DD. Inhibition of capping of immunoglobulin and concanavalin A receptors by cis-dichlorodiammine-platinum-(II) in mouse spleen cells. Cancer Lett. 1980 Sep; 10(3):261-7.
    View in: PubMed
  420. Papamichail M, Dimitracopoulos G, Tsokos G, Papavassiliou J. A human lymphocyte mitogen extracted from the extracellular slime layer of Pseudomonas aeruginosa. J Infect Dis. 1980 May; 141(5):686-8.
    View in: PubMed
  421. Papamichail M, Tsokos G, Paraskevas F. Release and reconstitution of Fc receptors from normal human mononuclear cells. Immunology. 1980 May; 40(1):47-52.
    View in: PubMed
  422. Papamichail M, Tsokos G, Tsawdaroglou N, Sekeris CE. Immunocytochemical demonstration of glucocorticoid receptors in different cell types and their translocation from the cytoplasm to the cell nucleus in the presence of dexamethasone. Exp Cell Res. 1980 Feb; 125(2):490-3.
    View in: PubMed
  423. Tsokos G, Mandyla H, Xanthou M, Papamichail M. Chlorpromazine and lidocaine inhibit antibody-dependent cell-mediated cytotoxicity but not erythrocyte antibody rosette formation. Int Arch Allergy Appl Immunol. 1980; 61(3):344-6.
    View in: PubMed
  424. Tsokos G, Papamichail M, Fessas P. A subpopulation of lymphocytes with T and B cell characteristics. Observations on two different cases of immunodeficiency. Acta Haematol. 1980; 63(2):88-93.
    View in: PubMed
  425. Papamichail M, Tsokos G, Pepys MB, Weyman C, Belin J, Smith AD. Inhibition of complement-dependent rosette formation after lymphocyte incubation with fatty acids. Immunology. 1979 Sep; 38(1):117-22.
    View in: PubMed
  426. Tsokos GC, Papamichail MG. The effect of sulfhydryl and amino group reagents on human lymphocyte--sheep erythrocyte rosettes. Exp Cell Biol. 1979; 47(3):183-9.
    View in: PubMed
  427. Zervas J, Tsokos G, Papadakis G, Kabouklis E, Papadopoulos D. HLA-B27 frequency in Greek patients with acute anterior uveitis. Br J Ophthalmol. 1977 Nov; 61(11):699-701.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Tsokos's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
Co-Authors
_
Similar People
_
Same Department
Physical Neighbors
_