 Raju Kucherlapati, PH.D.
| Title | Paul C. Cabot Professor of Genetics |
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| Institution | Harvard Medical School |
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| Department | Genetics |
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| Address | Harvard Medical School
Department of Genetics
77 Avenue Louis Pasteur
Boston MA 02115
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| Phone | 617/525-4445 |
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| Fax | 617/525-4440 |
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| Title | Professor of Medicine |
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| Institution | Brigham and Women's Hospital |
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| Department | Medicine |
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 Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
Faculty can login to make corrections and additions.
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Smpokou P, Tworog-Dube E, Kucherlapati RS, Roberts AE. Medical complications, clinical findings, and educational outcomes in adults with Noonan syndrome. Am J Med Genet A. 2012 Dec; 158A(12):3106-11.
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Hammerman PS, Hayes DN, Wilkerson MD, Schultz N, Bose R, Chu A, Collisson EA, Cope L, Creighton CJ, Getz G, Herman JG, Johnson BE, Kucherlapati R, Ladanyi M, Maher CA, Robertson G, Sander C, Shen R, Sinha R, Sivachenko A, Thomas RK, Travis WD, Tsao MS, Weinstein JN, Wigle DA, Baylin SB, Govindan R, Meyerson M. Comprehensive genomic characterization of squamous cell lung cancers. Nature. 2012 Sep 27; 489(7417):519-25.
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Kovalenko M, Dragileva E, St Claire J, Gillis T, Guide JR, New J, Dong H, Kucherlapati R, Kucherlapati MH, Ehrlich ME, Lee JM, Wheeler VC. Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice. PLoS One. 2012; 7(9):e44273.
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Sheth RA, Kunin A, Stangenberg L, Sinnamon M, Hung KE, Kucherlapati R, Mahmood U. In vivo optical molecular imaging of matrix metalloproteinase activity following celecoxib therapy for colorectal cancer. Mol Imaging. 2012 Sep-Oct; 11(5):417-25.
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Larman TC, DePalma SR, Hadjipanayis AG, Protopopov A, Zhang J, Gabriel SB, Chin L, Seidman CE, Kucherlapati R, Seidman JG. Spectrum of somatic mitochondrial mutations in five cancers. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14087-91.
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Kikinis Z, Asami T, Bouix S, Finn CT, Ballinger T, Tworog-Dube E, Kucherlapati R, Kikinis R, Shenton ME, Kubicki M. Reduced fractional anisotropy and axial diffusivity in white matter in 22q11.2 deletion syndrome: a pilot study. Schizophr Res. 2012 Oct; 141(1):35-9.
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Lee E, Iskow R, Yang L, Gokcumen O, Haseley P, Luquette LJ, Lohr JG, Harris CC, Ding L, Wilson RK, Wheeler DA, Gibbs RA, Kucherlapati R, Lee C, Kharchenko PV, Park PJ. Landscape of somatic retrotransposition in human cancers. Science. 2012 Aug 24; 337(6097):967-71.
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Kucherlapati R. Genetically modified mouse models for biomarker discovery and preclinical drug testing. Clin Cancer Res. 2012 Feb 1; 18(3):625-30.
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Ladd JJ, Busald T, Johnson MM, Zhang Q, Pitteri SJ, Wang H, Brenner DE, Lampe PD, Kucherlapati R, Feng Z, Prentice RL, Hanash SM. Increased plasma levels of the APC-interacting protein MAPRE1, LRG1, and IGFBP2 preceding a diagnosis of colorectal cancer in women. Cancer Prev Res (Phila). 2012 Apr; 5(4):655-64.
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Perlstein TS, Goldhaber SZ, Nelson K, Joshi V, Morgan TV, Lesko LJ, Lee JY, Gobburu J, Schoenfeld D, Kucherlapati R, Freeman MW, Creager MA. The Creating an Optimal Warfarin Nomogram (CROWN) Study. Thromb Haemost. 2012 Jan; 107(1):59-68.
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Xi R, Hadjipanayis AG, Luquette LJ, Kim TM, Lee E, Zhang J, Johnson MD, Muzny DM, Wheeler DA, Gibbs RA, Kucherlapati R, Park PJ. Copy number variation detection in whole-genome sequencing data using the Bayesian information criterion. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):E1128-36.
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Liao S, Cheng G, Conner DA, Huang Y, Kucherlapati RS, Munn LL, Ruddle NH, Jain RK, Fukumura D, Padera TP. Impaired lymphatic contraction associated with immunosuppression. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18784-9.
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Kucherlapati R. Introduction for: frontiers of personalized cancer medicine. Cancer J. 2011 Nov-Dec; 17(6):403-4.
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Taguchi A, Politi K, Pitteri SJ, Lockwood WW, Faça VM, Kelly-Spratt K, Wong CH, Zhang Q, Chin A, Park KS, Goodman G, Gazdar AF, Sage J, Dinulescu DM, Kucherlapati R, Depinho RA, Kemp CJ, Varmus HE, Hanash SM. Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell. 2011 Sep 13; 20(3):289-99.
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Hiramoto T, Kang G, Suzuki G, Satoh Y, Kucherlapati R, Watanabe Y, Hiroi N. Tbx1: identification of a 22q11.2 gene as a risk factor for autism spectrum disorder in a mouse model. Hum Mol Genet. 2011 Dec 15; 20(24):4775-85.
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McIlhatton MA, Tyler J, Kerepesi LA, Bocker-Edmonston T, Kucherlapati MH, Edelmann W, Kucherlapati R, Kopelovich L, Fishel R. Aspirin and low-dose nitric oxide-donating aspirin increase life span in a Lynch syndrome mouse model. Cancer Prev Res (Phila). 2011 May; 4(5):684-93.
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Chen PC, Wakimoto H, Conner D, Araki T, Yuan T, Roberts A, Seidman C, Bronson R, Neel B, Seidman JG, Kucherlapati R. Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation. J Clin Invest. 2010 Dec; 120(12):4353-65.
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McDonald DA, Shenkar R, Shi C, Stockton RA, Akers AL, Kucherlapati MH, Kucherlapati R, Brainer J, Ginsberg MH, Awad IA, Marchuk DA. A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease. Hum Mol Genet. 2011 Jan 15; 20(2):211-22.
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Chan AT, Baba Y, Shima K, Nosho K, Chung DC, Hung KE, Mahmood U, Madden K, Poss K, Ranieri A, Shue D, Kucherlapati R, Fuchs CS, Ogino S. Cathepsin B expression and survival in colon cancer: implications for molecular detection of neoplasia. Cancer Epidemiol Biomarkers Prev. 2010 Nov; 19(11):2777-85.
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Kucherlapati R. Personalized medicine for non-small-cell lung cancer. Oncology (Williston Park). 2010 Apr 30; 24(5):399-400.
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Kim P, Chung E, Yamashita H, Hung KE, Mizoguchi A, Kucherlapati R, Fukumura D, Jain RK, Yun SH. In vivo wide-area cellular imaging by side-view endomicroscopy. Nat Methods. 2010 Apr; 7(4):303-5.
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Wang Y, Zhang W, Edelmann L, Kolodner RD, Kucherlapati R, Edelmann W. Cis lethal genetic interactions attenuate and alter p53 tumorigenesis. Proc Natl Acad Sci U S A. 2010 Mar 23; 107(12):5511-5.
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Hung KE, Maricevich MA, Richard LG, Chen WY, Richardson MP, Kunin A, Bronson RT, Mahmood U, Kucherlapati R. Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment. Proc Natl Acad Sci U S A. 2010 Jan 26; 107(4):1565-70.
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Cirstea IC, Kutsche K, Dvorsky R, Gremer L, Carta C, Horn D, Roberts AE, Lepri F, Merbitz-Zahradnik T, König R, Kratz CP, Pantaleoni F, Dentici ML, Joshi VA, Kucherlapati RS, Mazzanti L, Mundlos S, Patton MA, Silengo MC, Rossi C, Zampino G, Digilio C, Stuppia L, Seemanova E, Pennacchio LA, Gelb BD, Dallapiccola B, Wittinghofer A, Ahmadian MR, Tartaglia M, Zenker M. A restricted spectrum of NRAS mutations causes Noonan syndrome. Nat Genet. 2010 Jan; 42(1):27-9.
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Kucherlapati MH, Lee K, Nguyen AA, Clark AB, Hou H, Rosulek A, Li H, Yang K, Fan K, Lipkin M, Bronson RT, Jelicks L, Kunkel TA, Kucherlapati R, Edelmann W. An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents. Gastroenterology. 2010 Mar; 138(3):993-1002.e1.
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Narr KL, Szeszko PR, Lencz T, Woods RP, Hamilton LS, Phillips O, Robinson D, Burdick KE, DeRosse P, Kucherlapati R, Thompson PM, Toga AW, Malhotra AK, Bilder RM. DTNBP1 is associated with imaging phenotypes in schizophrenia. Hum Brain Mapp. 2009 Nov; 30(11):3783-94.
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Lee I, Pecinova A, Pecina P, Neel BG, Araki T, Kucherlapati R, Roberts AE, Hüttemann M. A suggested role for mitochondria in Noonan syndrome. Biochim Biophys Acta. 2010 Feb; 1802(2):275-83.
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Itano O, Yang K, Fan K, Kurihara N, Shinozaki H, Abe S, Jin B, Gravaghi C, Edelmann W, Augenlicht L, Kopelovich L, Kucherlapati R, Lamprecht S, Lipkin M. Sulindac effects on inflammation and tumorigenesis in the intestine of mice with Apc and Mlh1 mutations. Carcinogenesis. 2009 Nov; 30(11):1923-6.
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Suzuki G, Harper KM, Hiramoto T, Funke B, Lee M, Kang G, Buell M, Geyer MA, Kucherlapati R, Morrow B, Männistö PT, Agatsuma S, Hiroi N. Over-expression of a human chromosome 22q11.2 segment including TXNRD2, COMT and ARVCF developmentally affects incentive learning and working memory in mice. Hum Mol Genet. 2009 Oct 15; 18(20):3914-25.
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Herman DS, Hovingh GK, Iartchouk O, Rehm HL, Kucherlapati R, Seidman JG, Seidman CE. Filter-based hybridization capture of subgenomes enables resequencing and copy-number detection. Nat Methods. 2009 Jul; 6(7):507-10.
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Wang XP, O'Connell DJ, Lund JJ, Saadi I, Kuraguchi M, Turbe-Doan A, Cavallesco R, Kim H, Park PJ, Harada H, Kucherlapati R, Maas RL. Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthood. Development. 2009 Jun; 136(11):1939-49.
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Vassilopoulos S, Esk C, Hoshino S, Funke BH, Chen CY, Plocik AM, Wright WE, Kucherlapati R, Brodsky FM. A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism. Science. 2009 May 29; 324(5931):1192-6.
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Luong MX, Tam J, Lin Q, Hagendoorn J, Moore KJ, Padera TP, Seed B, Fukumura D, Kucherlapati R, Jain RK. Lack of lymphatic vessel phenotype in LYVE-1/CD44 double knockout mice. J Cell Physiol. 2009 May; 219(2):430-7.
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Hung KE, Faca V, Song K, Sarracino DA, Richard LG, Krastins B, Forrester S, Porter A, Kunin A, Mahmood U, Haab BB, Hanash SM, Kucherlapati R. Comprehensive proteome analysis of an Apc mouse model uncovers proteins associated with intestinal tumorigenesis. Cancer Prev Res (Phila). 2009 Mar; 2(3):224-33.
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Kuraguchi M, Ohene-Baah NY, Sonkin D, Bronson RT, Kucherlapati R. Genetic mechanisms in Apc-mediated mammary tumorigenesis. PLoS Genet. 2009 Feb; 5(2):e1000367.
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Kucherlapati MH, Yang K, Fan K, Kuraguchi M, Sonkin D, Rosulek A, Lipkin M, Bronson RT, Aronow BJ, Kucherlapati R. Loss of Rb1 in the gastrointestinal tract of Apc1638N mice promotes tumors of the cecum and proximal colon. Proc Natl Acad Sci U S A. 2008 Oct 7; 105(40):15493-8.
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Montgomery KT, Iartchouck O, Li L, Loomis S, Obourn V, Kucherlapati R. PolyPhred analysis software for mutation detection from fluorescence-based sequence data. Curr Protoc Hum Genet. 2008 Oct; Chapter 7:Unit 7.16.
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Dragileva E, Hendricks A, Teed A, Gillis T, Lopez ET, Friedberg EC, Kucherlapati R, Edelmann W, Lunetta KL, MacDonald ME, Wheeler VC. Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes. Neurobiol Dis. 2009 Jan; 33(1):37-47.
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Yang K, Lamprecht SA, Shinozaki H, Fan K, Yang W, Newmark HL, Kopelovich L, Edelmann W, Jin B, Gravaghi C, Augenlicht L, Kucherlapati R, Lipkin M. Dietary calcium and cholecalciferol modulate cyclin D1 expression, apoptosis, and tumorigenesis in intestine of adenomatous polyposis coli1638N/+ mice. J Nutr. 2008 Sep; 138(9):1658-63.
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Gravaghi C, Bo J, Laperle KM, Quimby F, Kucherlapati R, Edelmann W, Lamprecht SA. Obesity enhances gastrointestinal tumorigenesis in Apc-mutant mice. Int J Obes (Lond). 2008 Nov; 32(11):1716-9.
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Chen PC, Kuraguchi M, Velasquez J, Wang Y, Yang K, Edwards R, Gillen D, Edelmann W, Kucherlapati R, Lipkin SM. Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression. PLoS Genet. 2008 Jun; 4(6):e1000092.
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Zhang Q, Menon R, Deutsch EW, Pitteri SJ, Faca VM, Wang H, Newcomb LF, Depinho RA, Bardeesy N, Dinulescu D, Hung KE, Kucherlapati R, Jacks T, Politi K, Aebersold R, Omenn GS, States DJ, Hanash SM. A mouse plasma peptide atlas as a resource for disease proteomics. Genome Biol. 2008; 9(6):R93.
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Joshi VA, Kucherlapati R. Genetics and genomics in the practice of medicine. Gastroenterology. 2008 May; 134(5):1284-8.
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Barrera-Oro J, Liu TY, Gorden E, Kucherlapati R, Shao C, Tischfield JA. Role of the mismatch repair gene, Msh6, in suppressing genome instability and radiation-induced mutations. Mutat Res. 2008 Jul 3; 642(1-2):74-9.
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Morita H, Rehm HL, Menesses A, McDonough B, Roberts AE, Kucherlapati R, Towbin JA, Seidman JG, Seidman CE. Shared genetic causes of cardiac hypertrophy in children and adults. N Engl J Med. 2008 May 1; 358(18):1899-908.
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Busuttil RA, Lin Q, Stambrook PJ, Kucherlapati R, Vijg J. Mutation frequencies and spectra in DNA polymerase eta-deficient mice. Cancer Res. 2008 Apr 1; 68(7):2081-4.
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Montgomery KT, Iartchouck O, Li L, Perera A, Yassin Y, Tamburino A, Loomis S, Kucherlapati R. Mutation detection using automated fluorescence-based sequencing. Curr Protoc Hum Genet. 2008 Apr; Chapter 7:Unit7.9.
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Avdievich E, Reiss C, Scherer SJ, Zhang Y, Maier SM, Jin B, Hou H, Rosenwald A, Riedmiller H, Kucherlapati R, Cohen PE, Edelmann W, Kneitz B. Distinct effects of the recurrent Mlh1G67R mutation on MMR functions, cancer, and meiosis. Proc Natl Acad Sci U S A. 2008 Mar 18; 105(11):4247-52.
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Swanson KD, Winter JM, Reis M, Bentires-Alj M, Greulich H, Grewal R, Hruban RH, Yeo CJ, Yassin Y, Iartchouk O, Montgomery K, Whitman SP, Caligiuri MA, Loh ML, Gilliland DG, Look AT, Kucherlapati R, Kern SE, Meyerson M, Neel BG. SOS1 mutations are rare in human malignancies: implications for Noonan Syndrome patients. Genes Chromosomes Cancer. 2008 Mar; 47(3):253-9.
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Lencz T, Lambert C, DeRosse P, Burdick KE, Morgan TV, Kane JM, Kucherlapati R, Malhotra AK. Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia. Proc Natl Acad Sci U S A. 2007 Dec 11; 104(50):19942-7.
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Martin ES, Tonon G, Sinha R, Xiao Y, Feng B, Kimmelman AC, Protopopov A, Ivanova E, Brennan C, Montgomery K, Kucherlapati R, Bailey G, Redston M, Chin L, DePinho RA. Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types. Cancer Res. 2007 Nov 15; 67(22):10736-43.
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Forrester S, Hung KE, Kuick R, Kucherlapati R, Haab BB. Low-volume, high-throughput sandwich immunoassays for profiling plasma proteins in mice: identification of early-stage systemic inflammation in a mouse model of intestinal cancer. Mol Oncol. 2007 Sep; 1(2):216-25.
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Joshi VA, Kucherlapati R. Pharmacogenomics of lung cancer: with a view to address EGFR-targeted therapies. Pharmacogenomics. 2007 Sep; 8(9):1211-20.
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Funke BH, Lencz T, Finn CT, DeRosse P, Poznik GD, Plocik AM, Kane J, Rogus J, Malhotra AK, Kucherlapati R. Analysis of TBX1 variation in patients with psychotic and affective disorders. Mol Med. 2007 Jul-Aug; 13(7-8):407-14.
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Burdick KE, Funke B, Goldberg JF, Bates JA, Jaeger J, Kucherlapati R, Malhotra AK. COMT genotype increases risk for bipolar I disorder and influences neurocognitive performance. Bipolar Disord. 2007 Jun; 9(4):370-6.
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Kucherlapati M, Nguyen A, Kuraguchi M, Yang K, Fan K, Bronson R, Wei K, Lipkin M, Edelmann W, Kucherlapati R. Tumor progression in Apc(1638N) mice with Exo1 and Fen1 deficiencies. Oncogene. 2007 Sep 20; 26(43):6297-306.
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Kucherlapati R. Raju Kucherlapati talks about personalised medicine: breathing new life into old drugs. Interview by Steve Carney. Drug Discov Today. 2007 Apr; 12(7-8):272-5.
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Lencz T, Morgan TV, Athanasiou M, Dain B, Reed CR, Kane JM, Kucherlapati R, Malhotra AK. Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia. Mol Psychiatry. 2007 Jun; 12(6):572-80.
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Kratz CP, Niemeyer CM, Thomas C, Bauhuber S, Matejas V, Bergsträsser E, Flotho C, Flores NJ, Haas O, Hasle H, van den Heuvel-Eibrink MM, Kucherlapati RS, Lang P, Roberts AE, Starý J, Strahm B, Swanson KD, Trebo M, Zecca M, Neel B, Locatelli F, Loh ML, Zenker M. Mutation analysis of Son of Sevenless in juvenile myelomonocytic leukemia. Leukemia. 2007 May; 21(5):1108-9.
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Funke BH, Brown AC, Ramoni MF, Regan ME, Baglieri C, Finn CT, Babcock M, Shprintzen RJ, Morrow BE, Kucherlapati R. A novel, single nucleotide polymorphism-based assay to detect 22q11 deletions. Genet Test. 2007; 11(1):91-100.
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Sequist LV, Joshi VA, Jänne PA, Muzikansky A, Fidias P, Meyerson M, Haber DA, Kucherlapati R, Johnson BE, Lynch TJ. Response to treatment and survival of patients with non-small cell lung cancer undergoing somatic EGFR mutation testing. Oncologist. 2007 Jan; 12(1):90-8.
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Roberts AE, Araki T, Swanson KD, Montgomery KT, Schiripo TA, Joshi VA, Li L, Yassin Y, Tamburino AM, Neel BG, Kucherlapati RS. Germline gain-of-function mutations in SOS1 cause Noonan syndrome. Nat Genet. 2007 Jan; 39(1):70-4.
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Dumstorf CA, Clark AB, Lin Q, Kissling GE, Yuan T, Kucherlapati R, McGregor WG, Kunkel TA. Participation of mouse DNA polymerase iota in strand-biased mutagenic bypass of UV photoproducts and suppression of skin cancer. Proc Natl Acad Sci U S A. 2006 Nov 28; 103(48):18083-8.
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Burdick KE, Goldberg TE, Funke B, Bates JA, Lencz T, Kucherlapati R, Malhotra AK. DTNBP1 genotype influences cognitive decline in schizophrenia. Schizophr Res. 2007 Jan; 89(1-3):169-72.
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Lee DG, Urbach JM, Wu G, Liberati NT, Feinbaum RL, Miyata S, Diggins LT, He J, Saucier M, Déziel E, Friedman L, Li L, Grills G, Montgomery K, Kucherlapati R, Rahme LG, Ausubel FM. Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial. Genome Biol. 2006; 7(10):R90.
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Long JM, LaPorte P, Merscher S, Funke B, Saint-Jore B, Puech A, Kucherlapati R, Morrow BE, Skoultchi AI, Wynshaw-Boris A. Behavior of mice with mutations in the conserved region deleted in velocardiofacial/DiGeorge syndrome. Neurogenetics. 2006 Nov; 7(4):247-57.
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Hung KE, Kho AT, Sarracino D, Richard LG, Krastins B, Forrester S, Haab BB, Kohane IS, Kucherlapati R. Mass spectrometry-based study of the plasma proteome in a mouse intestinal tumor model. J Proteome Res. 2006 Aug; 5(8):1866-78.
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Kuraguchi M, Wang XP, Bronson RT, Rothenberg R, Ohene-Baah NY, Lund JJ, Kucherlapati M, Maas RL, Kucherlapati R. Adenomatous polyposis coli (APC) is required for normal development of skin and thymus. PLoS Genet. 2006 Sep 15; 2(9):e146.
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Sequist LV, Joshi VA, Jänne PA, Bell DW, Fidias P, Lindeman NI, Louis DN, Lee JC, Mark EJ, Longtine J, Verlander P, Kucherlapati R, Meyerson M, Haber DA, Johnson BE, Lynch TJ. Epidermal growth factor receptor mutation testing in the care of lung cancer patients. Clin Cancer Res. 2006 Jul 15; 12(14 Pt 2):4403s-4408s.
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DeRosse P, Funke B, Burdick KE, Lencz T, Goldberg TE, Kane JM, Kucherlapati R, Malhotra AK. COMT genotype and manic symptoms in schizophrenia. Schizophr Res. 2006 Oct; 87(1-3):28-31.
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Kates WR, Antshel KM, Abdulsabur N, Colgan D, Funke B, Fremont W, Higgins AM, Kucherlapati R, Shprintzen RJ. A gender-moderated effect of a functional COMT polymorphism on prefrontal brain morphology and function in velo-cardio-facial syndrome (22q11.2 deletion syndrome). Am J Med Genet B Neuropsychiatr Genet. 2006 Apr 5; 141B(3):274-80.
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Kucherlapati MH, Nguyen AA, Bronson RT, Kucherlapati RS. Inactivation of conditional Rb by Villin-Cre leads to aggressive tumors outside the gastrointestinal tract. Cancer Res. 2006 Apr 1; 66(7):3576-83.
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Hagendoorn J, Tong R, Fukumura D, Lin Q, Lobo J, Padera TP, Xu L, Kucherlapati R, Jain RK. Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis. Cancer Res. 2006 Apr 1; 66(7):3360-4.
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Scherer SE, Muzny DM, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Montgomery KT, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Lovering RC, Wheeler DA, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clerc-Blankenburg KP, Davis C, Delgado O, Dinh HH, Draper H, Gonzalez-Garay ML, Havlak P, Jackson LR, Jacob LS, Kelly SH, Li L, Li Z, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Pasternak S, Perez LM, Plopper FJ, Santibanez J, Shen H, Tabor PE, Verduzco D, Waldron L, Wang Q, Williams GA, Zhang J, Zhou J, Allen CC, Amin AG, Anyalebechi V, Bailey M, Barbaria JA, Bimage KE, Bryant NP, Burch PE, Burkett CE, Burrell KL, Calderon E, Cardenas V, Carter K, Casias K, Cavazos I, Cavazos SR, Ceasar H, Chacko J, Chan SN, Chavez D, Christopoulos C, Chu J, Cockrell R, Cox CD, Dang M, Dathorne SR, David R, Davis CM, Davy-Carroll L, Deshazo DR, Donlin JE, D'Souza L, Eaves KA, Egan A, Emery-Cohen AJ, Escotto M, Flagg N, Forbes LD, Gabisi AM, Garza M, Hamilton C, Henderson N, Hernandez O, Hines S, Hogues ME, Huang M, Idlebird DG, Johnson R, Jolivet A, Jones S, Kagan R, King LM, Leal B, Lebow H, Lee S, LeVan JM, Lewis LC, London P, Lorensuhewa LM, Loulseged H, Lovett DA, Lucier A, Lucier RL, Ma J, Madu RC, Mapua P, Martindale AD, Martinez E, Massey E, Mawhiney S, Meador MG, Mendez S, Mercado C, Mercado IC, Merritt CE, Miner ZL, Minja E, Mitchell T, Mohabbat F, Mohabbat K, Montgomery B, Moore N, Morris S, Munidasa M, Ngo RN, Nguyen NB, Nickerson E, Nwaokelemeh OO, Nwokenkwo S, Obregon M, Oguh M, Oragunye N, Oviedo RJ, Parish BJ, Parker DN, Parrish J, Parks KL, Paul HA, Payton BA, Perez A, Perrin W, Pickens A, Primus EL, Pu LL, Puazo M, Quiles MM, Quiroz JB, Rabata D, Reeves K, Ruiz SJ, Shao H, Sisson I, Sonaike T, Sorelle RP, Sutton AE, Svatek AF, Svetz LA, Tamerisa KS, Taylor TR, Teague B, Thomas N, Thorn RD, Trejos ZY, Trevino BK, Ukegbu ON, Urban JB, Vasquez LI, Vera VA, Villasana DM, Wang L, Ward-Moore S, Warren JT, Wei X, White F, Williamson AL, Wleczyk R, Wooden HS, Wooden SH, Yen J, Yoon L, Yoon V, Zorrilla SE, Nelson D, Kucherlapati R, Weinstock G, Gibbs RA. The finished DNA sequence of human chromosome 12. Nature. 2006 Mar 16; 440(7082):346-51.
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DeRosse P, Funke B, Burdick KE, Lencz T, Ekholm JM, Kane JM, Kucherlapati R, Malhotra AK. Dysbindin genotype and negative symptoms in schizophrenia. Am J Psychiatry. 2006 Mar; 163(3):532-4.
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Klein J, Ju W, Heyer J, Wittek B, Haneke T, Knaus P, Kucherlapati R, Böttinger EP, Nitschke L, Kneitz B. B cell-specific deficiency for Smad2 in vivo leads to defects in TGF-beta-directed IgA switching and changes in B cell fate. J Immunol. 2006 Feb 15; 176(4):2389-96.
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Moran JL, Bolton AD, Tran PV, Brown A, Dwyer ND, Manning DK, Bjork BC, Li C, Montgomery K, Siepka SM, Vitaterna MH, Takahashi JS, Wiltshire T, Kwiatkowski DJ, Kucherlapati R, Beier DR. Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse. Genome Res. 2006 Mar; 16(3):436-40.
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Burdick KE, Lencz T, Funke B, Finn CT, Szeszko PR, Kane JM, Kucherlapati R, Malhotra AK. Genetic variation in DTNBP1 influences general cognitive ability. Hum Mol Genet. 2006 May 15; 15(10):1563-8.
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Joshi VA, Kucherlapati R. Lung cancer genetics and pharmacogenomics. Cytogenet Genome Res. 2006; 115(3-4):298-302.
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Lin Q, Clark AB, McCulloch SD, Yuan T, Bronson RT, Kunkel TA, Kucherlapati R. Increased susceptibility to UV-induced skin carcinogenesis in polymerase eta-deficient mice. Cancer Res. 2006 Jan 1; 66(1):87-94.
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Ju W, Ogawa A, Heyer J, Nierhof D, Yu L, Kucherlapati R, Shafritz DA, Böttinger EP. Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation. Mol Cell Biol. 2006 Jan; 26(2):654-67.
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Hiroi N, Zhu H, Lee M, Funke B, Arai M, Itokawa M, Kucherlapati R, Morrow B, Sawamura T, Agatsuma S. A 200-kb region of human chromosome 22q11.2 confers antipsychotic-responsive behavioral abnormalities in mice. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):19132-7.
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Funke B, Malhotra AK, Finn CT, Plocik AM, Lake SL, Lencz T, DeRosse P, Kane JM, Kucherlapati R. COMT genetic variation confers risk for psychotic and affective disorders: a case control study. Behav Brain Funct. 2005 Oct 18; 1:19.
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Zervas M, Opitz T, Edelmann W, Wainer B, Kucherlapati R, Stanton PK. Impaired hippocampal long-term potentiation in microtubule-associated protein 1B-deficient mice. J Neurosci Res. 2005 Oct 1; 82(1):83-92.
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Yang K, Fan KH, Lamprecht SA, Edelmann W, Kopelovich L, Kucherlapati R, Lipkin M. Peroxisome proliferator-activated receptor gamma agonist troglitazone induces colon tumors in normal C57BL/6J mice and enhances colonic carcinogenesis in Apc1638 N/+ Mlh1+/- double mutant mice. Int J Cancer. 2005 Sep 10; 116(4):495-9.
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Ziv S, Brenner O, Amariglio N, Smorodinsky NI, Galron R, Carrion DV, Zhang W, Sharma GG, Pandita RK, Agarwal M, Elkon R, Katzin N, Bar-Am I, Pandita TK, Kucherlapati R, Rechavi G, Shiloh Y, Barzilai A. Impaired genomic stability and increased oxidative stress exacerbate different features of Ataxia-telangiectasia. Hum Mol Genet. 2005 Oct 1; 14(19):2929-43.
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Lai WR, Johnson MD, Kucherlapati R, Park PJ. Comparative analysis of algorithms for identifying amplifications and deletions in array CGH data. Bioinformatics. 2005 Oct 1; 21(19):3763-70.
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Owen BA, Yang Z, Lai M, Gajec M, Gajek M, Badger JD, Hayes JJ, Edelmann W, Kucherlapati R, Wilson TM, McMurray CT. (CAG)(n)-hairpin DNA binds to Msh2-Msh3 and changes properties of mismatch recognition. Nat Struct Mol Biol. 2005 Aug; 12(8):663-70.
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Wang Y, Putnam CD, Kane MF, Zhang W, Edelmann L, Russell R, Carrión DV, Chin L, Kucherlapati R, Kolodner RD, Edelmann W. Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice. Nat Genet. 2005 Jul; 37(7):750-5.
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Dziejman M, Serruto D, Tam VC, Sturtevant D, Diraphat P, Faruque SM, Rahman MH, Heidelberg JF, Decker J, Li L, Montgomery KT, Grills G, Kucherlapati R, Mekalanos JJ. Genomic characterization of non-O1, non-O139 Vibrio cholerae reveals genes for a type III secretion system. Proc Natl Acad Sci U S A. 2005 Mar 1; 102(9):3465-70.
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Roberts AE, Hult B, Rehm HL, Rehm HL, McDonough B, Barr S, Seidman CE, Seidman JG, Kucherlapati RS. The PTPN11 gene is not implicated in nonsyndromic hypertrophic cardiomyopathy. Am J Med Genet A. 2005 Jan 30; 132A(3):333-4.
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Shao C, Deng L, Chen Y, Kucherlapati R, Stambrook PJ, Tischfield JA. Mlh1 mediates tissue-specific regulation of mitotic recombination. Oncogene. 2004 Dec 2; 23(56):9017-24.
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Funke B, Finn CT, Plocik AM, Lake S, DeRosse P, Kane JM, Kucherlapati R, Malhotra AK. Association of the DTNBP1 locus with schizophrenia in a U.S. population. Am J Hum Genet. 2004 Nov; 75(5):891-8.
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Yang G, Scherer SJ, Shell SS, Yang K, Kim M, Lipkin M, Kucherlapati R, Kolodner RD, Edelmann W. Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility. Cancer Cell. 2004 Aug; 6(2):139-50.
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Lin DP, Wang Y, Scherer SJ, Clark AB, Yang K, Avdievich E, Jin B, Werling U, Parris T, Kurihara N, Umar A, Kucherlapati R, Lipkin M, Kunkel TA, Edelmann W. An Msh2 point mutation uncouples DNA mismatch repair and apoptosis. Cancer Res. 2004 Jan 15; 64(2):517-22.
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Kabbarah O, Mallon MA, Pfeifer JD, Edelmann W, Kucherlapati R, Goodfellow PJ. A panel of repeat markers for detection of microsatellite instability in murine tumors. Mol Carcinog. 2003 Dec; 38(4):155-9.
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Pretlow TP, Edelmann W, Kucherlapati R, Pretlow TG, Augenlicht LH. Spontaneous aberrant crypt foci in Apc1638N mice with a mutant Apc allele. Am J Pathol. 2003 Nov; 163(5):1757-63.
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Young LC, Peters AC, Maeda T, Edelmann W, Kucherlapati R, Andrew SE, Tron VA. DNA mismatch repair protein Msh6 is required for optimal levels of ultraviolet-B-induced apoptosis in primary mouse fibroblasts. J Invest Dermatol. 2003 Oct; 121(4):876-80.
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Yang YC, Piek E, Zavadil J, Liang D, Xie D, Heyer J, Pavlidis P, Kucherlapati R, Roberts AB, Böttinger EP. Hierarchical model of gene regulation by transforming growth factor beta. Proc Natl Acad Sci U S A. 2003 Sep 2; 100(18):10269-74.
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Takahashi C, Bronson RT, Socolovsky M, Contreras B, Lee KY, Jacks T, Noda M, Kucherlapati R, Ewen ME. Rb and N-ras function together to control differentiation in the mouse. Mol Cell Biol. 2003 Aug; 23(15):5256-68.
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Shinozaki H, Yang K, Fan K, Edelmann W, Kucherlapati R, Weinstein IB, Lipkin M. Cyclin D1 expression in the intestinal mucosa and tumors of Apc1638N mice. Anticancer Res. 2003 May-Jun; 23(3B):2217-26.
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Supavekin S, Zhang W, Kucherlapati R, Kaskel FJ, Moore LC, Devarajan P. Differential gene expression following early renal ischemia/reperfusion. Kidney Int. 2003 May; 63(5):1714-24.
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Yang K, Fan K, Kurihara N, Shinozaki H, Rigas B, Augenlicht L, Kopelovich L, Edelmann W, Kucherlapati R, Lipkin M. Regional response leading to tumorigenesis after sulindac in small and large intestine of mice with Apc mutations. Carcinogenesis. 2003 Mar; 24(3):605-11.
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Waterston RH, Lindblad-Toh K, Birney E, Rogers J, Abril JF, Agarwal P, Agarwala R, Ainscough R, Alexandersson M, An P, Antonarakis SE, Attwood J, Baertsch R, Bailey J, Barlow K, Beck S, Berry E, Birren B, Bloom T, Bork P, Botcherby M, Bray N, Brent MR, Brown DG, Brown SD, Bult C, Burton J, Butler J, Campbell RD, Carninci P, Cawley S, Chiaromonte F, Chinwalla AT, Church DM, Clamp M, Clee C, Collins FS, Cook LL, Copley RR, Coulson A, Couronne O, Cuff J, Curwen V, Cutts T, Daly M, David R, Davies J, Delehaunty KD, Deri J, Dermitzakis ET, Dewey C, Dickens NJ, Diekhans M, Dodge S, Dubchak I, Dunn DM, Eddy SR, Elnitski L, Emes RD, Eswara P, Eyras E, Felsenfeld A, Fewell GA, Flicek P, Foley K, Frankel WN, Fulton LA, Fulton RS, Furey TS, Gage D, Gibbs RA, Glusman G, Gnerre S, Goldman N, Goodstadt L, Grafham D, Graves TA, Green ED, Gregory S, Guigó R, Guyer M, Hardison RC, Haussler D, Hayashizaki Y, Hillier LW, Hinrichs A, Hlavina W, Holzer T, Hsu F, Hua A, Hubbard T, Hunt A, Jackson I, Jaffe DB, Johnson LS, Jones M, Jones TA, Joy A, Kamal M, Karlsson EK, Karolchik D, Kasprzyk A, Kawai J, Keibler E, Kells C, Kent WJ, Kirby A, Kolbe DL, Korf I, Kucherlapati RS, Kulbokas EJ, Kulp D, Landers T, Leger JP, Leonard S, Letunic I, Levine R, Li J, Li M, Lloyd C, Lucas S, Ma B, Maglott DR, Mardis ER, Matthews L, Mauceli E, Mayer JH, McCarthy M, McCombie WR, McLaren S, McLay K, McPherson JD, Meldrim J, Meredith B, Mesirov JP, Miller W, Miner TL, Mongin E, Montgomery KT, Morgan M, Mott R, Mullikin JC, Muzny DM, Nash WE, Nelson JO, Nhan MN, Nicol R, Ning Z, Nusbaum C, O'Connor MJ, Okazaki Y, Oliver K, Overton-Larty E, Pachter L, Parra G, Pepin KH, Peterson J, Pevzner P, Plumb R, Pohl CS, Poliakov A, Ponce TC, Ponting CP, Potter S, Quail M, Reymond A, Roe BA, Roskin KM, Rubin EM, Rust AG, Santos R, Sapojnikov V, Schultz B, Schultz J, Schwartz MS, Schwartz S, Scott C, Seaman S, Searle S, Sharpe T, Sheridan A, Shownkeen R, Sims S, Singer JB, Slater G, Smit A, Smith DR, Spencer B, Stabenau A, Stange-Thomann N, Sugnet C, Suyama M, Tesler G, Thompson J, Torrents D, Trevaskis E, Tromp J, Ucla C, Ureta-Vidal A, Vinson JP, Von Niederhausern AC, Wade CM, Wall M, Weber RJ, Weiss RB, Wendl MC, West AP, Wetterstrand K, Wheeler R, Whelan S, Wierzbowski J, Willey D, Williams S, Wilson RK, Winter E, Worley KC, Wyman D, Yang S, Yang SP, Zdobnov EM, Zody MC, Lander ES. Initial sequencing and comparative analysis of the mouse genome. Nature. 2002 Dec 5; 420(6915):520-62.
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Bourdon V, Naef F, Rao PH, Reuter V, Mok SC, Bosl GJ, Koul S, Murty VV, Kucherlapati RS, Chaganti RS. Genomic and expression analysis of the 12p11-p12 amplicon using EST arrays identifies two novel amplified and overexpressed genes. Cancer Res. 2002 Nov 1; 62(21):6218-23.
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Kochilas L, Merscher-Gomez S, Lu MM, Potluri V, Liao J, Kucherlapati R, Morrow B, Epstein JA. The role of neural crest during cardiac development in a mouse model of DiGeorge syndrome. Dev Biol. 2002 Nov 1; 251(1):157-66.
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Girnun GD, Smith WM, Drori S, Sarraf P, Mueller E, Eng C, Nambiar P, Rosenberg DW, Bronson RT, Edelmann W, Kucherlapati R, Gonzalez FJ, Spiegelman BM. APC-dependent suppression of colon carcinogenesis by PPARgamma. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13771-6.
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Kucherlapati M, Yang K, Kuraguchi M, Zhao J, Lia M, Heyer J, Kane MF, Fan K, Russell R, Brown AM, Kneitz B, Edelmann W, Kolodner RD, Lipkin M, Kucherlapati R. Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):9924-9.
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Wei K, Kucherlapati R, Edelmann W. Mouse models for human DNA mismatch-repair gene defects. Trends Mol Med. 2002 Jul; 8(7):346-53.
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Fritz B, Schubert F, Wrobel G, Schwaenen C, Wessendorf S, Nessling M, Korz C, Rieker RJ, Montgomery K, Kucherlapati R, Mechtersheimer G, Eils R, Joos S, Lichter P. Microarray-based copy number and expression profiling in dedifferentiated and pleomorphic liposarcoma. Cancer Res. 2002 Jun 1; 62(11):2993-8.
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Desai KV, Xiao N, Wang W, Gangi L, Greene J, Powell JI, Dickson R, Furth P, Hunter K, Kucherlapati R, Simon R, Liu ET, Green JE. Initiating oncogenic event determines gene-expression patterns of human breast cancer models. Proc Natl Acad Sci U S A. 2002 May 14; 99(10):6967-72.
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Tartaglia M, Kalidas K, Shaw A, Song X, Musat DL, van der Burgt I, Brunner HG, Bertola DR, Crosby A, Ion A, Kucherlapati RS, Jeffery S, Patton MA, Gelb BD. PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity. Am J Hum Genet. 2002 Jun; 70(6):1555-63.
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Wang H, Douglas W, Lia M, Edelmann W, Kucherlapati R, Podsypanina K, Parsons R, Ellenson LH. DNA mismatch repair deficiency accelerates endometrial tumorigenesis in Pten heterozygous mice. Am J Pathol. 2002 Apr; 160(4):1481-6.
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Velcich A, Yang W, Heyer J, Fragale A, Nicholas C, Viani S, Kucherlapati R, Lipkin M, Yang K, Augenlicht L. Colorectal cancer in mice genetically deficient in the mucin Muc2. Science. 2002 Mar 1; 295(5560):1726-9.
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Costa RM, Federov NB, Kogan JH, Murphy GG, Stern J, Ohno M, Kucherlapati R, Jacks T, Silva AJ. Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature. 2002 Jan 31; 415(6871):526-30.
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Tartaglia M, Mehler EL, Goldberg R, Zampino G, Brunner HG, Kremer H, van der Burgt I, Crosby AH, Ion A, Jeffery S, Kalidas K, Patton MA, Kucherlapati RS, Gelb BD. Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome. Nat Genet. 2001 Dec; 29(4):465-8.
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Hörig H, Wainstein A, Long L, Kahn D, Soni S, Marcus A, Edelmann W, Kucherlapati R, Kaufman HL. A new mouse model for evaluating the immunotherapy of human colorectal cancer. Cancer Res. 2001 Dec 1; 61(23):8520-6.
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Kuraguchi M, Yang K, Wong E, Avdievich E, Fan K, Kolodner RD, Lipkin M, Brown AM, Kucherlapati R, Edelmann W. The distinct spectra of tumor-associated Apc mutations in mismatch repair-deficient Apc1638N mice define the roles of MSH3 and MSH6 in DNA repair and intestinal tumorigenesis. Cancer Res. 2001 Nov 1; 61(21):7934-42.
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Yang W, Velcich A, Mariadason J, Nicholas C, Corner G, Houston M, Edelmann W, Kucherlapati R, Holt PR, Augenlicht LH. p21(WAF1/cip1) is an important determinant of intestinal cell response to sulindac in vitro and in vivo. Cancer Res. 2001 Aug 15; 61(16):6297-302.
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Kucherlapati R, DePinho RA. Cancer. Telomerase meets its mismatch. Nature. 2001 Jun 7; 411(6838):647-8.
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Kucherlapati R, Lin DP, Edelmann W. Mouse models for human familial adenomatous polyposis. Semin Cancer Biol. 2001 Jun; 11(3):219-25.
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Piek E, Ju WJ, Heyer J, Escalante-Alcalde D, Stewart CL, Weinstein M, Deng C, Kucherlapati R, Bottinger EP, Roberts AB. Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts. J Biol Chem. 2001 Jun 8; 276(23):19945-53.
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Merscher S, Funke B, Epstein JA, Heyer J, Puech A, Lu MM, Xavier RJ, Demay MB, Russell RG, Factor S, Tokooya K, Jore BS, Lopez M, Pandita RK, Lia M, Carrion D, Xu H, Schorle H, Kobler JB, Scambler P, Wynshaw-Boris A, Skoultchi AI, Morrow BE, Kucherlapati R. TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome. Cell. 2001 Feb 23; 104(4):619-29.
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Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, Funke R, Gage D, Harris K, Heaford A, Howland J, Kann L, Lehoczky J, LeVine R, McEwan P, McKernan K, Meldrim J, Mesirov JP, Miranda C, Morris W, Naylor J, Raymond C, Rosetti M, Santos R, Sheridan A, Sougnez C, Stange-Thomann N, Stojanovic N, Subramanian A, Wyman D, Rogers J, Sulston J, Ainscough R, Beck S, Bentley D, Burton J, Clee C, Carter N, Coulson A, Deadman R, Deloukas P, Dunham A, Dunham I, Durbin R, French L, Grafham D, Gregory S, Hubbard T, Humphray S, Hunt A, Jones M, Lloyd C, McMurray A, Matthews L, Mercer S, Milne S, Mullikin JC, Mungall A, Plumb R, Ross M, Shownkeen R, Sims S, Waterston RH, Wilson RK, Hillier LW, McPherson JD, Marra MA, Mardis ER, Fulton LA, Chinwalla AT, Pepin KH, Gish WR, Chissoe SL, Wendl MC, Delehaunty KD, Miner TL, Delehaunty A, Kramer JB, Cook LL, Fulton RS, Johnson DL, Minx PJ, Clifton SW, Hawkins T, Branscomb E, Predki P, Richardson P, Wenning S, Slezak T, Doggett N, Cheng JF, Olsen A, Lucas S, Elkin C, Uberbacher E, Frazier M, Gibbs RA, Muzny DM, Scherer SE, Bouck JB, Sodergren EJ, Worley KC, Rives CM, Gorrell JH, Metzker ML, Naylor SL, Kucherlapati RS, Nelson DL, Weinstock GM, Sakaki Y, Fujiyama A, Hattori M, Yada T, Toyoda A, Itoh T, Kawagoe C, Watanabe H, Totoki Y, Taylor T, Weissenbach J, Heilig R, Saurin W, Artiguenave F, Brottier P, Bruls T, Pelletier E, Robert C, Wincker P, Smith DR, Doucette-Stamm L, Rubenfield M, Weinstock K, Lee HM, Dubois J, Rosenthal A, Platzer M, Nyakatura G, Taudien S, Rump A, Yang H, Yu J, Wang J, Huang G, Gu J, Hood L, Rowen L, Madan A, Qin S, Davis RW, Federspiel NA, Abola AP, Proctor MJ, Myers RM, Schmutz J, Dickson M, Grimwood J, Cox DR, Olson MV, Kaul R, Raymond C, Shimizu N, Kawasaki K, Minoshima S, Evans GA, Athanasiou M, Schultz R, Roe BA, Chen F, Pan H, Ramser J, Lehrach H, Reinhardt R, McCombie WR, de la Bastide M, Dedhia N, Blöcker H, Hornischer K, Nordsiek G, Agarwala R, Aravind L, Bailey JA, Bateman A, Batzoglou S, Birney E, Bork P, Brown DG, Burge CB, Cerutti L, Chen HC, Church D, Clamp M, Copley RR, Doerks T, Eddy SR, Eichler EE, Furey TS, Galagan J, Gilbert JG, Harmon C, Hayashizaki Y, Haussler D, Hermjakob H, Hokamp K, Jang W, Johnson LS, Jones TA, Kasif S, Kaspryzk A, Kennedy S, Kent WJ, Kitts P, Koonin EV, Korf I, Kulp D, Lancet D, Lowe TM, McLysaght A, Mikkelsen T, Moran JV, Mulder N, Pollara VJ, Ponting CP, Schuler G, Schultz J, Slater G, Smit AF, Stupka E, Szustakowski J, Thierry-Mieg D, Thierry-Mieg J, Wagner L, Wallis J, Wheeler R, Williams A, Wolf YI, Wolfe KH, Yang SP, Yeh RF, Collins F, Guyer MS, Peterson J, Felsenfeld A, Wetterstrand KA, Patrinos A, Morgan MJ, de Jong P, Catanese JJ, Osoegawa K, Shizuya H, Choi S, Chen YJ, Szustakowki J. Initial sequencing and analysis of the human genome. Nature. 2001 Feb 15; 409(6822):860-921.
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Montgomery KT, Lee E, Miller A, Lau S, Shim C, Decker J, Chiu D, Emerling S, Sekhon M, Kim R, Lenz J, Han J, Ioshikhes I, Renault B, Marondel I, Yoon SJ, Song K, Murty VV, Scherer S, Yonescu R, Kirsch IR, Ried T, McPherson J, Gibbs R, Kucherlapati R. A high-resolution map of human chromosome 12. Nature. 2001 Feb 15; 409(6822):945-6.
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Yang WC, Mathew J, Velcich A, Edelmann W, Kucherlapati R, Lipkin M, Yang K, Augenlicht LH. Targeted inactivation of the p21(WAF1/cip1) gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosal. Cancer Res. 2001 Jan 15; 61(2):565-9.
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Kuraguchi M, Edelmann W, Yang K, Lipkin M, Kucherlapati R, Brown AM. Tumor-associated Apc mutations in Mlh1-/- Apc1638N mice reveal a mutational signature of Mlh1 deficiency. Oncogene. 2000 Nov 23; 19(50):5755-63.
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Ion A, Crosby AH, Kremer H, Kenmochi N, Van Reen M, Fenske C, Van Der Burgt I, Brunner HG, Montgomery K, Kucherlapati RS, Patton MA, Page C, Mariman E, Jeffery S. Detailed mapping, mutation analysis, and intragenic polymorphism identification in candidate Noonan syndrome genes MYL2, DCN, EPS8, and RPL6. J Med Genet. 2000 Nov; 37(11):884-6.
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Smits R, Hofland N, Edelmann W, Geugien M, Jagmohan-Changur S, Albuquerque C, Breukel C, Kucherlapati R, Kielman MF, Fodde R. Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity. Genes Chromosomes Cancer. 2000 Nov; 29(3):229-39.
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Lee H, Choi E, Seomun Y, Montgomery K, Huebner A, Lee E, Lau S, Joo CK, Kucherlapati R, Yoon SJ. High-resolution transcript map of the region spanning D12S1629 and D12S312 at chromosome 12q13: triple A syndrome-linked region. Genome Res. 2000 Oct; 10(10):1561-7.
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Marcus DM, Rustgi AK, Defoe D, Kucherlapati R, Edelmann W, Hamasaki D, Liou GI, Smith SB. Ultrastructural and ERG findings in mice with adenomatous polyposis coli gene disruption. Mol Vis. 2000 Sep 8; 6:169-77.
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Casey M, Vaughan CJ, He J, Hatcher CJ, Winter JM, Weremowicz S, Montgomery K, Kucherlapati R, Morton CC, Basson CT. Mutations in the protein kinase A R1alpha regulatory subunit cause familial cardiac myxomas and Carney complex. J Clin Invest. 2000 Sep; 106(5):R31-8.
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Peyron C, Faraco J, Rogers W, Ripley B, Overeem S, Charnay Y, Nevsimalova S, Aldrich M, Reynolds D, Albin R, Li R, Hungs M, Pedrazzoli M, Padigaru M, Kucherlapati M, Fan J, Maki R, Lammers GJ, Bouras C, Kucherlapati R, Nishino S, Mignot E. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med. 2000 Sep; 6(9):991-7.
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Puech A, Saint-Jore B, Merscher S, Russell RG, Cherif D, Sirotkin H, Xu H, Factor S, Kucherlapati R, Skoultchi AI. Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/DiGeorge syndrome region. Proc Natl Acad Sci U S A. 2000 Aug 29; 97(18):10090-5.
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Bala S, Oliver H, Renault B, Montgomery K, Dutta S, Rao P, Houldsworth J, Kucherlapati R, Wang X, Chaganti RS, Murty VV. Genetic analysis of the APAF1 gene in male germ cell tumors. Genes Chromosomes Cancer. 2000 Jul; 28(3):258-68.
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Kneitz B, Cohen PE, Avdievich E, Zhu L, Kane MF, Hou H, Kolodner RD, Kucherlapati R, Pollard JW, Edelmann W. MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. Genes Dev. 2000 May 1; 14(9):1085-97.
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Pellegata NS, Dieguez-Lucena JL, Joensuu T, Lau S, Montgomery KT, Krahe R, Kivelä T, Kucherlapati R, Forsius H, de la Chapelle A. Mutations in KERA, encoding keratocan, cause cornea plana. Nat Genet. 2000 May; 25(1):91-5.
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Renedo M, Arce I, Montgomery K, Roda-Navarro P, Lee E, Kucherlapati R, Fernández-Ruiz E. A sequence-ready physical map of the region containing the human natural killer gene complex on chromosome 12p12.3-p13.2. Genomics. 2000 Apr 15; 65(2):129-36.
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Edelmann W, Umar A, Yang K, Heyer J, Kucherlapati M, Lia M, Kneitz B, Avdievich E, Fan K, Wong E, Crouse G, Kunkel T, Lipkin M, Kolodner RD, Kucherlapati R. The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression. Cancer Res. 2000 Feb 15; 60(4):803-7.
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Roda-Navarro P, Arce I, Renedo M, Montgomery K, Kucherlapati R, Fernández-Ruiz E. Human KLRF1, a novel member of the killer cell lectin-like receptor gene family: molecular characterization, genomic structure, physical mapping to the NK gene complex and expression analysis. Eur J Immunol. 2000 Feb; 30(2):568-76.
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Wu G, Markowitz GS, Li L, D'Agati VD, Factor SM, Geng L, Tibara S, Tuchman J, Cai Y, Park JH, van Adelsberg J, Hou H, Kucherlapati R, Edelmann W, Somlo S. Cardiac defects and renal failure in mice with targeted mutations in Pkd2. Nat Genet. 2000 Jan; 24(1):75-8.
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Lee SG, Cho KA, Choi YH, Montgomery K, Lee E, Miller A, Kucherlapati R, Song K. A sequence-ready map for human chromosome 12q15-21. DNA Seq. 2000; 11(3-4):353-61.
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Augenlicht LH, Anthony GM, Church TL, Edelmann W, Kucherlapati R, Yang K, Lipkin M, Heerdt BG. Short-chain fatty acid metabolism, apoptosis, and Apc-initiated tumorigenesis in the mouse gastrointestinal mucosa. Cancer Res. 1999 Dec 1; 59(23):6005-9.
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Heyer J, Escalante-Alcalde D, Lia M, Boettinger E, Edelmann W, Stewart CL, Kucherlapati R. Postgastrulation Smad2-deficient embryos show defects in embryo turning and anterior morphogenesis. Proc Natl Acad Sci U S A. 1999 Oct 26; 96(22):12595-600.
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Heyer J, Yang K, Lipkin M, Edelmann W, Kucherlapati R. Mouse models for colorectal cancer. Oncogene. 1999 Sep 20; 18(38):5325-33.
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Schrader CE, Edelmann W, Kucherlapati R, Stavnezer J. Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes. J Exp Med. 1999 Aug 2; 190(3):323-30.
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Murty VV, Montgomery K, Dutta S, Bala S, Renault B, Bosl GJ, Kucherlapati R, Chaganti RS. A 3-Mb high-resolution BAC/PAC contig of 12q22 encompassing the 830-kb consensus minimal deletion in male germ cell tumors. Genome Res. 1999 Jul; 9(7):662-71.
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Smits R, Kielman MF, Breukel C, Zurcher C, Neufeld K, Jagmohan-Changur S, Hofland N, van Dijk J, White R, Edelmann W, Kucherlapati R, Khan PM, Fodde R. Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development. Genes Dev. 1999 May 15; 13(10):1309-21.
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Weiss A, McDonough D, Wertman B, Acakpo-Satchivi L, Montgomery K, Kucherlapati R, Leinwand L, Krauter K. Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):2958-63.
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Edelmann W, Yang K, Kuraguchi M, Heyer J, Lia M, Kneitz B, Fan K, Brown AM, Lipkin M, Kucherlapati R. Tumorigenesis in Mlh1 and Mlh1/Apc1638N mutant mice. Cancer Res. 1999 Mar 15; 59(6):1301-7.
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Sakuntabhai A, Ruiz-Perez V, Carter S, Jacobsen N, Burge S, Monk S, Smith M, Munro CS, O'Donovan M, Craddock N, Kucherlapati R, Rees JL, Owen M, Lathrop GM, Monaco AP, Strachan T, Hovnanian A. Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nat Genet. 1999 Mar; 21(3):271-7.
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Mahmoud NN, Bilinski RT, Churchill MR, Edelmann W, Kucherlapati R, Bertagnolli MM. Genotype-phenotype correlation in murine Apc mutation: differences in enterocyte migration and response to sulindac. Cancer Res. 1999 Jan 15; 59(2):353-9.
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Cheung VG, Morley M, Aguilar F, Massimi A, Kucherlapati R, Childs G. Making and reading microarrays. Nat Genet. 1999 Jan; 21(1 Suppl):15-9.
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Edelmann W, Cohen PE, Kneitz B, Winand N, Lia M, Heyer J, Kolodner R, Pollard JW, Kucherlapati R. Mammalian MutS homologue 5 is required for chromosome pairing in meiosis. Nat Genet. 1999 Jan; 21(1):123-7.
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Lipkin M, Yang K, Edelmann W, Xue L, Fan K, Risio M, Newmark H, Kucherlapati R. Preclinical mouse models for cancer chemoprevention studies. Ann N Y Acad Sci. 1999; 889:14-9.
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Yang K, Edelmann W, Fan K, Lau K, Leung D, Newmark H, Kucherlapati R, Lipkin M. Dietary modulation of carcinoma development in a mouse model for human familial adenomatous polyposis. Cancer Res. 1998 Dec 15; 58(24):5713-7.
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Saint-Jore B, Puech A, Heyer J, Lin Q, Raine C, Kucherlapati R, Skoultchi AI. Goosecoid-like (Gscl), a candidate gene for velocardiofacial syndrome, is not essential for normal mouse development. Hum Mol Genet. 1998 Nov; 7(12):1841-9.
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Ness SL, Edelmann W, Jenkins TD, Liedtke W, Rustgi AK, Kucherlapati R. Mouse keratin 4 is necessary for internal epithelial integrity. J Biol Chem. 1998 Sep 11; 273(37):23904-11.
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Kucherlapati R. Gene knockouts galore. Nat Biotechnol. 1998 Jun; 16(6):519-20.
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Wu G, D'Agati V, Cai Y, Markowitz G, Park JH, Reynolds DM, Maeda Y, Le TC, Hou H, Kucherlapati R, Edelmann W, Somlo S. Somatic inactivation of Pkd2 results in polycystic kidney disease. Cell. 1998 Apr 17; 93(2):177-88.
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Liedtke W, Edelmann W, Chiu FC, Kucherlapati R, Raine CS. Experimental autoimmune encephalomyelitis in mice lacking glial fibrillary acidic protein is characterized by a more severe clinical course and an infiltrative central nervous system lesion. Am J Pathol. 1998 Jan; 152(1):251-9.
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Puech A, Saint-Jore B, Funke B, Gilbert DJ, Sirotkin H, Copeland NG, Jenkins NA, Kucherlapati R, Morrow B, Skoultchi AI. Comparative mapping of the human 22q11 chromosomal region and the orthologous region in mice reveals complex changes in gene organization. Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14608-13.
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Funke B, Saint-Jore B, Puech A, Sirotkin H, Edelmann L, Carlson C, Raft S, Pandita RK, Kucherlapati R, Skoultchi A, Morrow BE. Characterization and mutation analysis of goosecoid-like (GSCL), a homeodomain-containing gene that maps to the critical region for VCFS/DGS on 22q11. Genomics. 1997 Dec 15; 46(3):364-72.
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Sato Y, Bohlander SK, Kobayashi H, Reshmi S, Suto Y, Davis EM, Espinosa R, Hoopes R, Montgomery KT, Kucherlapati RS, Le Beau MM, Rowley JD. Heterogeneity in the breakpoints in balanced rearrangements involving band 12p13 in hematologic malignancies identified by fluorescence in situ hybridization: TEL (ETV6 ) is involved in only one half. Blood. 1997 Dec 15; 90(12):4886-93.
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Acakpo-Satchivi LJ, Edelmann W, Sartorius C, Lu BD, Wahr PA, Watkins SC, Metzger JM, Leinwand L, Kucherlapati R. Growth and muscle defects in mice lacking adult myosin heavy chain genes. J Cell Biol. 1997 Dec 1; 139(5):1219-29.
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Merscher S, Marondel I, Pedeutour F, Gaudray P, Kucherlapati R, Turc-Carel C. Identification of new translocation breakpoints at 12q13 in lipomas. Genomics. 1997 Nov 15; 46(1):70-7.
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Edelmann W, Yang K, Umar A, Heyer J, Lau K, Fan K, Liedtke W, Cohen PE, Kane MF, Lipford JR, Yu N, Crouse GF, Pollard JW, Kunkel T, Lipkin M, Kolodner R, Kucherlapati R. Mutation in the mismatch repair gene Msh6 causes cancer susceptibility. Cell. 1997 Nov 14; 91(4):467-77.
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Renault B, Hovnanian A, Bryce S, Chang JJ, Lau S, Sakuntabhai A, Monk S, Carter S, Ross CJ, Pang J, Twells R, Chamberlain S, Monaco AP, Strachan T, Kucherlapati R. A sequence-ready physical map of a region of 12q24.1. Genomics. 1997 Oct 15; 45(2):271-8.
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Johnson L, Greenbaum D, Cichowski K, Mercer K, Murphy E, Schmitt E, Bronson RT, Umanoff H, Edelmann W, Kucherlapati R, Jacks T. K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev. 1997 Oct 1; 11(19):2468-81.
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Fox JG, Dangler CA, Whary MT, Edelman W, Kucherlapati R, Wang TC. Mice carrying a truncated Apc gene have diminished gastric epithelial proliferation, gastric inflammation, and humoral immunity in response to Helicobacter felis infection. Cancer Res. 1997 Sep 15; 57(18):3972-8.
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Carlson C, Sirotkin H, Pandita R, Goldberg R, McKie J, Wadey R, Patanjali SR, Weissman SM, Anyane-Yeboa K, Warburton D, Scambler P, Shprintzen R, Kucherlapati R, Morrow BE. Molecular definition of 22q11 deletions in 151 velo-cardio-facial syndrome patients. Am J Hum Genet. 1997 Sep; 61(3):620-9.
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Sirotkin H, Morrow B, Saint-Jore B, Puech A, Das Gupta R, Patanjali SR, Skoultchi A, Weissman SM, Kucherlapati R. Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome. Genomics. 1997 Jun 1; 42(2):245-51.
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Marcus DM, Rustgi AK, Defoe D, Brooks SE, McCormick RS, Thompson TP, Edelmann W, Kucherlapati R, Smith S. Retinal pigment epithelium abnormalities in mice with adenomatous polyposis coli gene disruption. Arch Ophthalmol. 1997 May; 115(5):645-50.
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Sirotkin H, O'Donnell H, DasGupta R, Halford S, St Jore B, Puech A, Parimoo S, Morrow B, Skoultchi A, Weissman SM, Scambler P, Kucherlapati R. Identification of a new human catenin gene family member (ARVCF) from the region deleted in velo-cardio-facial syndrome. Genomics. 1997 Apr 1; 41(1):75-83.
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Carlson C, Papolos D, Pandita RK, Faedda GL, Veit S, Goldberg R, Shprintzen R, Kucherlapati R, Morrow B. Molecular analysis of velo-cardio-facial syndrome patients with psychiatric disorders. Am J Hum Genet. 1997 Apr; 60(4):851-9.
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Yang K, Edelmann W, Fan K, Lau K, Kolli VR, Fodde R, Khan PM, Kucherlapati R, Lipkin M. A mouse model of human familial adenomatous polyposis. J Exp Zool. 1997 Feb 15; 277(3):245-54.
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Smits R, Kartheuser A, Jagmohan-Changur S, Leblanc V, Breukel C, de Vries A, van Kranen H, van Krieken JH, Williamson S, Edelmann W, Kucherlapati R. Loss of Apc and the entire chromosome 18 but absence of mutations at the Ras and Tp53 genes in intestinal tumors from Apc1638N, a mouse model for Apc-driven carcinogenesis. Carcinogenesis. 1997 Feb; 18(2):321-7.
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Hamann J, Montgomery KT, Lau S, Kucherlapati R, van Lier RA. AICL: a new activation-induced antigen encoded by the human NK gene complex. Immunogenetics. 1997; 45(5):295-300.
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Kucherlapati R, Marynen P, Turc-Carel C. Report of the fourth International Workshop in Human Chromosome 12 Mapping, 1997. Cytogenet Cell Genet. 1997; 78(2):82-95.
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Basson CT, Bachinsky DR, Lin RC, Levi T, Elkins JA, Soults J, Grayzel D, Kroumpouzou E, Traill TA, Leblanc-Straceski J, Renault B, Kucherlapati R, Seidman JG, Seidman CE. Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome. Nat Genet. 1997 Jan; 15(1):30-5.
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Deere M, Johnson J, Garza S, Harrison WR, Yoon SJ, Elder FF, Kucherlapati R, Hook M, Hecht JT. Characterization of human DSPG3, a small dermatan sulfate proteoglycan. Genomics. 1996 Dec 15; 38(3):399-404.
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Papolos DF, Faedda GL, Veit S, Goldberg R, Morrow B, Kucherlapati R, Shprintzen RJ. Bipolar spectrum disorders in patients diagnosed with velo-cardio-facial syndrome: does a hemizygous deletion of chromosome 22q11 result in bipolar affective disorder? Am J Psychiatry. 1996 Dec; 153(12):1541-7.
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Marondel I, Renault B, Lieman J, Ward D, Kucherlapati R. Physical mapping of the human neurotensin gene (NTS) between markers D12S1444 and D12S81 on chromosome 12q21. Genomics. 1996 Dec 1; 38(2):243-5.
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Barnes KC, Neely JD, Duffy DL, Freidhoff LR, Breazeale DR, Schou C, Naidu RP, Levett PN, Renault B, Kucherlapati R, Iozzino S, Ehrlich E, Beaty TH, Marsh DG. Linkage of asthma and total serum IgE concentration to markers on chromosome 12q: evidence from Afro-Caribbean and Caucasian populations. Genomics. 1996 Oct 1; 37(1):41-50.
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Liedtke W, Edelmann W, Bieri PL, Chiu FC, Cowan NJ, Kucherlapati R, Raine CS. GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination. Neuron. 1996 Oct; 17(4):607-15.
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Lachman HM, Morrow B, Shprintzen R, Veit S, Parsia SS, Faedda G, Goldberg R, Kucherlapati R, Papolos DF. Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome. Am J Med Genet. 1996 Sep 20; 67(5):468-72.
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Schoenberg Fejzo M, Ashar HR, Krauter KS, Powell WL, Rein MS, Weremowicz S, Yoon SJ, Kucherlapati RS, Chada K, Morton CC. Translocation breakpoints upstream of the HMGIC gene in uterine leiomyomata suggest dysregulation of this gene by a mechanism different from that in lipomas. Genes Chromosomes Cancer. 1996 Sep; 17(1):1-6.
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Murty VV, Renault B, Falk CT, Bosl GJ, Kucherlapati R, Chaganti RS. Physical mapping of a commonly deleted region, the site of a candidate tumor suppressor gene, at 12q22 in human male germ cell tumors. Genomics. 1996 Aug 1; 35(3):562-70.
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Kuefer MU, Look AT, Williams DC, Valentine V, Naeve CW, Behm FG, Mullersman JE, Yoneda-Kato N, Montgomery K, Kucherlapati R, Morris SW. cDNA cloning, tissue distribution, and chromosomal localization of myelodysplasia/myeloid leukemia factor 2 (MLF2). Genomics. 1996 Jul 15; 35(2):392-6.
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Edelmann W, Cohen PE, Kane M, Lau K, Morrow B, Bennett S, Umar A, Kunkel T, Cattoretti G, Chaganti R, Pollard JW, Kolodner RD, Kucherlapati R. Meiotic pachytene arrest in MLH1-deficient mice. Cell. 1996 Jun 28; 85(7):1125-34.
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Edelmann W, Kucherlapati R. Role of recombination enzymes in mammalian cell survival. Proc Natl Acad Sci U S A. 1996 Jun 25; 93(13):6225-7.
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Johnson DW, Berg JN, Baldwin MA, Gallione CJ, Marondel I, Yoon SJ, Stenzel TT, Speer M, Pericak-Vance MA, Diamond A, Guttmacher AE, Jackson CE, Attisano L, Kucherlapati R, Porteous ME, Marchuk DA. Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2. Nat Genet. 1996 Jun; 13(2):189-95.
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Sirotkin H, Morrow B, DasGupta R, Goldberg R, Patanjali SR, Shi G, Cannizzaro L, Shprintzen R, Weissman SM, Kucherlapati R. Isolation of a new clathrin heavy chain gene with muscle-specific expression from the region commonly deleted in velo-cardio-facial syndrome. Hum Mol Genet. 1996 May; 5(5):617-24.
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Edelmann W, Zervas M, Costello P, Roback L, Fischer I, Hammarback JA, Cowan N, Davies P, Wainer B, Kucherlapati R. Neuronal abnormalities in microtubule-associated protein 1B mutant mice. Proc Natl Acad Sci U S A. 1996 Feb 6; 93(3):1270-5.
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Cupelli L, Renault B, Leblanc-Straceski J, Banks A, Ward D, Kucherlapati RS, Krauter K. Assignment of the human myogenic factors 5 and 6 (MYF5, MYF6) gene cluster to 12q21 by in situ hybridization and physical mapping of the locus between D12S350 and D12S106. Cytogenet Cell Genet. 1996; 72(2-3):250-1.
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Marynen P, Kucherlapati R. Report of the Third International Workshop on Human Chromosome 12 Mapping 1995. Cytogenet Cell Genet. 1996; 73(1-2):1-24.
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Lipkin M, Yang K, Edelmann W, Newmark H, Fan KH, Risio M, Kucherlapati R. Inherited and acquired risk factors in colonic neoplasia and modulation by chemopreventive interventions. J Cell Biochem Suppl. 1996; 25:136-41.
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Van de Ven W, Hagemeijer A, Kucherlapati R, Marynen P. Report of the International Meeting on Chromosome 12 Genes in Cancer. Cytogenet Cell Genet. 1996; 73(1-2):25-32.
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Miller PL, Nadkarni PM, Kidd KK, Cheung K, Ward DC, Banks A, Bray-Ward P, Cupelli L, Herdman V, Marondel I, Montgomery K, Renault B, Yoon SJ, Krauter KS, Kucherlapati R. Internet-based support for bioscience research: a collaborative genome center for human chromosome 12. J Am Med Inform Assoc. 1995 Nov-Dec; 2(6):351-64.
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Renault B, Lieman J, Ward D, Krauter K, Kucherlapati R. Localization of the human achaete-scute homolog gene (ASCL1) distal to phenylalanine hydroxylase (PAH) and proximal to tumor rejection antigen (TRA1) on chromosome 12q22-q23. Genomics. 1995 Nov 1; 30(1):81-3.
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Engle EC, Marondel I, Houtman WA, de Vries B, Loewenstein A, Lazar M, Ward DC, Kucherlapati R, Beggs AH. Congenital fibrosis of the extraocular muscles (autosomal dominant congenital external ophthalmoplegia): genetic homogeneity, linkage refinement, and physical mapping on chromosome 12. Am J Hum Genet. 1995 Nov; 57(5):1086-94.
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Davies RL, Yoon SJ, Weissenbach J, Ward D, Krauter K, Kucherlapati R. Physical mapping of the human ELA1 gene between D12S361 and D12S347 on chromosome 12q13. Genomics. 1995 Oct 10; 29(3):766-8.
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Campbell C, Marondel I, Montgomery K, Krauter K, Kucherlapati R. Unequal homologous recombination of human DNA on a yeast artificial chromosome. Nucleic Acids Res. 1995 Sep 25; 23(18):3691-5.
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Lindsay EA, Goldberg R, Jurecic V, Morrow B, Carlson C, Kucherlapati RS, Shprintzen RJ, Baldini A. Velo-cardio-facial syndrome: frequency and extent of 22q11 deletions. Am J Med Genet. 1995 Jul 3; 57(3):514-22.
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Sirotkin AM, Edelmann W, Cheng G, Klein-Szanto A, Kucherlapati R, Skoultchi AI. Mice develop normally without the H1(0) linker histone. Proc Natl Acad Sci U S A. 1995 Jul 3; 92(14):6434-8.
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Umanoff H, Edelmann W, Pellicer A, Kucherlapati R. The murine N-ras gene is not essential for growth and development. Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1709-13.
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Miller PL, Nadkarni PM, Kucherlapati R, Krauter KS, Kidd KK, Ward DC, Shepherd GM, Berkowicz D. Network-based informatics support of research collaborations in the Human Genome Project and the Human Brain Project. Medinfo. 1995; 8 Pt 2:1541-4.
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Yoon SJ, LeBlanc-Straceski J, Ward D, Krauter K, Kucherlapati R. Organization of the human keratin type II gene cluster at 12q13. Genomics. 1994 Dec; 24(3):502-8.
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Kobayashi H, Montgomery KT, Bohlander SK, Adra CN, Lim BL, Kucherlapati RS, Donis-Keller H, Holt MS, Le Beau MM, Rowley JD. Fluorescence in situ hybridization mapping of translocations and deletions involving the short arm of human chromosome 12 in malignant hematologic diseases. Blood. 1994 Nov 15; 84(10):3473-82.
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Carter SA, Bryce SD, Munro CS, Healy E, Bashir R, Weissenbach J, LeBlanc-Straceski J, Kucherlapati R, Stephenson A, Rees JL, et al. Linkage analyses in British pedigrees suggest a single locus for Darier disease and narrow the location to the interval between D12S105 and D12S129. Genomics. 1994 Nov 15; 24(2):378-82.
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Pedeutour F, Merscher S, Durieux E, Montgomery K, Krauter K, Clevy JP, Barcelo G, Kucherlapati R, Gaudray P, Turc-Carel C. Mapping of the 12q12-q22 region with respect to tumor translocation breakpoints. Genomics. 1994 Aug; 22(3):512-8.
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Chan YM, Yu QC, LeBlanc-Straceski J, Christiano A, Pulkkinen L, Kucherlapati RS, Uitto J, Fuchs E. Mutations in the non-helical linker segment L1-2 of keratin 5 in patients with Weber-Cockayne epidermolysis bullosa simplex. J Cell Sci. 1994 Apr; 107 ( Pt 4):765-74.
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LeBlanc-Straceski JM, Montgomery KT, Kissel H, Murtaugh L, Tsai P, Ward DC, Krauter KS, Kucherlapati R. Twenty-one polymorphic markers from human chromosome 12 for integration of genetic and physical maps. Genomics. 1994 Jan 15; 19(2):341-9.
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Kucherlapati R, Craig I, Marynen P. Report and abstracts of the Second International Workshop on Human Chromosome 12 mapping 1994. New Haven, Connecticut, June 20-22, 1994. Cytogenet Cell Genet. 1994; 67(4):245-76.
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Morrow B, Kucherlapati R. Gene targeting in mammalian cells by homologous recombination. Curr Opin Biotechnol. 1993 Oct; 4(5):577-82.
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Montgomery KT, LeBlanc JM, Tsai P, McNinch JS, Ward DC, de Jong PJ, Kucherlapati R, Krauter KS. Characterization of two chromosome 12 cosmid libraries and development of STSs from cosmids mapped by FISH. Genomics. 1993 Sep; 17(3):682-93.
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Das Gupta R, Morrow B, Marondel I, Parimoo S, Goei VL, Gruen J, Weissman S, Skoultchi A, Kucherlapati R. An integrated approach for identifying and mapping human genes. Proc Natl Acad Sci U S A. 1993 May 15; 90(10):4364-8.
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McKusik VA, Kucherlapati RS, Ruddle FH. Genomics: stock-taking after 5 years. Genomics. 1993 Jan; 15(1):1-2.
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Yoon SJ, Seiler SH, Kucherlapati R, Leinwand L. Organization of the human skeletal myosin heavy chain gene cluster. Proc Natl Acad Sci U S A. 1992 Dec 15; 89(24):12078-82.
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Craig I, Gemmill R, Kucherlapati R. Report of the first international workshop on human chromosome 12 mapping. Cytogenet Cell Genet. 1992; 61(4):243-51.
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Schwartz F, Maeda N, Smithies O, Hickey R, Edelmann W, Skoultchi A, Kucherlapati R. A dominant positive and negative selectable gene for use in mammalian cells. Proc Natl Acad Sci U S A. 1991 Dec 1; 88(23):10416-20.
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Campbell C, Gulati R, Nandi AK, Floy K, Hieter P, Kucherlapati RS. Generation of a nested series of interstitial deletions in yeast artificial chromosomes carrying human DNA. Proc Natl Acad Sci U S A. 1991 Jul 1; 88(13):5744-8.
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Camerini-Otero RD, Kucherlapati R. Right on target. Applications of Homologous Recombination to Human Disease sponsored by the National Institutes of Health (NIGMS, NIDDK, and NICHD) Bethesda, MD, USA, November 6-8, 1989. New Biol. 1990 Apr; 2(4):337-41.
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Keown WA, Campbell CR, Kucherlapati RS. Methods for introducing DNA into mammalian cells. Methods Enzymol. 1990; 185:527-37.
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Campbell CR, Keown W, Lowe L, Kirschling D, Kucherlapati R. Homologous recombination involving small single-stranded oligonucleotides in human cells. New Biol. 1989 Nov; 1(2):223-7.
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Campbell CR, Ayares D, Watkins K, Wolski R, Kucherlapati R. Single-stranded DNA gaps, tails and loops are repaired in Escherichia coli. Mutat Res. 1989 Mar; 211(1):181-8.
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Kucherlapati RS. Homologous recombination in mammalian somatic cells. Prog Nucleic Acid Res Mol Biol. 1989; 36:301-10.
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Song KY, Schwartz F, Maeda N, Smithies O, Kucherlapati R. Accurate modification of a chromosomal plasmid by homologous recombination in human cells. Proc Natl Acad Sci U S A. 1987 Oct; 84(19):6820-4.
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Ganea D, Moore P, Chekuri L, Kucherlapati R. Characterization of an ATP-dependent DNA strand transferase from human cells. Mol Cell Biol. 1987 Sep; 7(9):3124-30.
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Kucherlapati R. Gene replacement by homologous recombination in mammalian cells. Somat Cell Mol Genet. 1987 Jul; 13(4):447-9.
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Ayares D, Ganea D, Chekuri L, Campbell CR, Kucherlapati R. Repair of single-stranded DNA nicks, gaps, and loops in mammalian cells. Mol Cell Biol. 1987 May; 7(5):1656-62.
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Rauth S, Song KY, Ayares D, Wallace L, Moore PD, Kucherlapati R. Transfection and homologous recombination involving single-stranded DNA substrates in mammalian cells and nuclear extracts. Proc Natl Acad Sci U S A. 1986 Aug; 83(15):5587-91.
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Ayares D, Chekuri L, Song KY, Kucherlapati R. Sequence homology requirements for intermolecular recombination in mammalian cells. Proc Natl Acad Sci U S A. 1986 Jul; 83(14):5199-203.
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Moore PD, Song KY, Chekuri L, Wallace L, Kucherlapati RS. Homologous recombination in a Chinese hamster X-ray-sensitive mutant. Mutat Res. 1986 Apr; 160(2):149-55.
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Song KY, Chekuri L, Rauth S, Ehrlich S, Kucherlapati R. Effect of double-strand breaks on homologous recombination in mammalian cells and extracts. Mol Cell Biol. 1985 Dec; 5(12):3331-6.
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Ayares D, Spencer J, Schwartz F, Morse B, Kucherlapati R. Homologous recombination between autonomously replicating plasmids in mammalian cells. Genetics. 1985 Oct; 111(2):375-88.
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Smithies O, Gregg RG, Boggs SS, Koralewski MA, Kucherlapati RS. Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination. Nature. 1985 Sep 19-25; 317(6034):230-4.
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Strazdis J, Lanahan A, Johnson DE, Bothwell M, Kucherlapati R. The epidermal growth factor (EGF) receptor gene studied using gene transfer. Int J Neurosci. 1985 Apr; 26(1-2):129-40.
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Kucherlapati RS, Spencer J, Moore PD. Homologous recombination catalyzed by human cell extracts. Mol Cell Biol. 1985 Apr; 5(4):714-20.
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Kucherlapati RS, Eves EM, Song KY, Morse BS, Smithies O. Homologous recombination between plasmids in mammalian cells can be enhanced by treatment of input DNA. Proc Natl Acad Sci U S A. 1984 May; 81(10):3153-7.
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Clough DW, Morse BS, Kucherlapati RS, Davidson RL. Insulin-induced reactivation of an inactive herpes simplex thymidine kinase gene. Proc Natl Acad Sci U S A. 1984 Feb; 81(3):838-42.
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Kucherlapati R, Skoultchi AI. Introduction of purified genes into mammalian cells. CRC Crit Rev Biochem. 1984; 16(4):349-79.
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Kucherlapati RS, Ayares D, Hanneken A, Noonan K, Rauth S, Spencer JM, Wallace L, Moore PD. Homologous recombination in monkey cells and human cell-free extracts. Cold Spring Harb Symp Quant Biol. 1984; 49:191-7.
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Smithies O, Koralewski MA, Song KY, Kucherlapati RS. Homologous recombination with DNA introduced into mammalian cells. Cold Spring Harb Symp Quant Biol. 1984; 49:161-70.
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Roginski RS, Skoultchi AI, Henthorn P, Smithies O, Hsiung N, Kucherlapati R. Coordinate modulation of transfected HSV thymidine kinase and human globin genes. Cell. 1983 Nov; 35(1):149-55.
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Davies RL, Rifkin DB, Tepper R, Miller A, Kucherlapati R. A polypeptide secreted by transformed cells that modulates human plasminogen activator production. Science. 1983 Jul 8; 221(4606):171-3.
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Hwang SP, Kucherlapati RS. Events preceding stable integration of SV40 genomes in a human cell line. Somatic Cell Genet. 1983 Jul; 9(4):457-68.
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Gilboa E, Kolbe M, Noonan K, Kucherlapati R. Construction of a mammalian transducing vector from the genome of Moloney murine leukemia virus. J Virol. 1982 Dec; 44(3):845-51.
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Davies RL, Fuhrer-Krusi S, Kucherlapati RS. Modulation of transfected gene expression mediated by changes in chromatin structure. Cell. 1982 Dec; 31(3 Pt 2):521-9.
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Hsiung N, Roginski RS, Henthorn P, Smithies O, Kucherlapati R, Skoultchi AI. Introduction and expression of a fetal human globin gene in mouse fibroblasts. Mol Cell Biol. 1982 Apr; 2(4):401-11.
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Hsiung N, Kucherlapati R. Histone gene expression and chromatin structure in mammalian cell hybrids. J Cell Biol. 1980 Oct; 87(1):227-36.
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Hsiung N, Warrick H, deRiel JK, Tuan D, Forget BG, Skoultchi A, Kucherlapati R. Cotransfer of circular and linear prokaryotic and eukaryotic DNA sequences into mouse cells. Proc Natl Acad Sci U S A. 1980 Aug; 77(8):4852-6.
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Hwang SP, Kucherlapati R. Localization and organization of integrated simian virus 40 sequences in a human cell line. Virology. 1980 Aug; 105(1):196-204.
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Warrick H, Hsiung N, Shows TB, Kucherlapati R. DNA-mediated cotransfer of unlinked mammalian cell markers into mouse L cells. J Cell Biol. 1980 Jul; 86(1):341-6.
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Davies RL, Grosse VA, Kucherlapati R, Bothwell M. Genetic analysis of epidermal growth factor action: assignment of human epidermal growth factor receptor gene to chromosome 7. Proc Natl Acad Sci U S A. 1980 Jul; 77(7):4188-92.
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Pyati J, Kucherlapati RS, Skoultchi AI. Activation of human beta-globin genes from nonerythroid cells by fusion with murine erythroleukemia cells. Proc Natl Acad Sci U S A. 1980 Jun; 77(6):3435-9.
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Wolin SL, Kucherlapati RS. Expression of microtubule networks in normal cells, transformed cells, and their hybrids. J Cell Biol. 1979 Jul; 82(1):76-85.
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Kucherlapati R, Shin SI. Genetic control of tumorigenicity in interspecific mammalian cell hybrids. Cell. 1979 Mar; 16(3):639-48.
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Kucherlapati R, Tepper R, Granelli-Piperno A, Reich E. Modulation and mapping of a human plasminogen activator by cell fusion. Cell. 1978 Dec; 15(4):1331-40.
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Kucherlapati R, Hwang SP, Shimizu N, McDougall JK, Botchan MR. Another chromosomal assignment for a simian virus 40 integration site in human cells. Proc Natl Acad Sci U S A. 1978 Sep; 75(9):4460-4.
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Turner BM, Smith M, Turner VS, Kucherlapati RS, Ruddle FH, Hirschhorn K. Assignment of the gene locus for human alpha-L-fucosidase to chromosome 1 by analysis of somatic cell hybrids. Somatic Cell Genet. 1978 Jan; 4(1):45-54.
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Levy R, Dilley J, Sikora K, Kucherlapati R. Mouse-human hybridomas. The conversion of non-secreting human B cells into Ig secretors. Curr Top Microbiol Immunol. 1978; 81:170-2.
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Deisseroth A, Nienhuis A, Turner P, Velez R, Anderson WF, Ruddle F, Lawrence J, Creagan R, Kucherlapati R. Localization of the human alpha-globin structural gene to chromosome 16 in somatic cell hybrids by molecular hybridization assay. Cell. 1977 Sep; 12(1):205-18.
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Willecke K, Teber T, Kucherlapati RS, Ruddle FH. Human mitochondrial thymidine kinase is coded for by a gene on chromosome 16 of the nucleus. Somatic Cell Genet. 1977 May; 3(3):237-45.
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Shimizu N, Giles RE, Kucherlapati RS, Shimizu Y, Ruddle FH. Somatic cell genetic assignment of the human gene for mitochondrial NADP-linked isocitrate dehydrogenase to the long arm of chromosome 15. Somatic Cell Genet. 1977 Jan; 3(1):47-60.
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Shimizu N, Kucherlapati RS, Ruddle FH. Assignment of a human gene for tryptophanyl-tRNA synthetase to chromosome 14 using human-mouse somatic cell hybrids. Somatic Cell Genet. 1976 Jul; 2(4):345-57.
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Friend KK, Dorman BP, Kucherlapati RS, Ruddle FH. Detection of interspecific translocations in mouse-human hybrids by alkaline Giemsa staining. Exp Cell Res. 1976 Apr; 99(1):31-6.
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Faber HE, Kucherlapati RS, Poulik MD, Ruddle FH, Smithies O. beta2-microglobulin locus on human chromosome 15. Somatic Cell Genet. 1976 Mar; 2(2):141-53.
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Kucherlapati RS, Ruddle FH. Assignment of the human genes for mannose phosphate isomerase, pyruvate kinase (M2), and hexosaminidase-A to chromosome 15. Cytogenet Cell Genet. 1976; 16(1-5):181-3.
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Willecke K, Reber T, Kucherlapati RS, Ruddle FH. Segregation of human mitochondrial thymidine kinase activity in human-mouse somatic cell hybrids. Cytogenet Cell Genet. 1976; 16(1-5):252-5.
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Schacter B, Kucherlapati RS, Ruddle FH. Synteny of the loci for beta2-microglobulin and PKM2 in man-mouse somatic cell hybrid subclones. Birth Defects Orig Artic Ser. 1976; 12(7):215-8.
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Shimizu N, Kucherlapati RS, Ruddle FH. Assignment of the human gene for tryptophanyl-tRNA synthetase using human-mouse somatic cell hybrids. Cytogenet Cell Genet. 1976; 16(1-5):223-6.
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Klobutcher LA, Nichols EA, Kucherlapati RS, Ruddle FH. Assignment of the gene for human adenosine kinase to chromosome 10 using a somatic cell hybrid clone panel. Cytogenet Cell Genet. 1976; 16(1-5):171-4.
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Kucherlapati RS, Ruddle FH. Advances in human gene mapping by parasexual procedures. Prog Med Genet. 1976; 1:121-44.
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McDogall JK, Gallimore PH, Dunn AR, Webb TP, Kucherlapati RS, Nichols EA, Ruddle FH. Mapping viral integation sites in somatic cell hybrids. Birth Defects Orig Artic Ser. 1976; 12(7):206-10.
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Anderson WF, Deisseroth AB, Velez R, Nienhuis AW, Ruddle FH, Kucherlapati RS. A new technique for mapping the human hemoglobin genes. Birth Defects Orig Artic Ser. 1976; 12(7):367-71.
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Anderson WF, Deisseroth AB, Velez R, Nienhuis AW, Ruddle FH, Kucherlapati RS. A new technique for mapping the human hemoglobin genes. Cytogenet Cell Genet. 1976; 16(1-5):367-71.
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Kucherlapati RS, Faber HE, Poulik MD, Ruddle FH, Smithies O. Assignment of the gene for beta-2-microglobulin to human chromosome 15. Cytogenet Cell Genet. 1976; 16(1-5):178-80.
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Turner VS, Turner BM, Kucherlapati R, Ruddle FH, Hirschhorn K. Assignment of the human alpha-l-fucosidase gene locus to chromosome 1 by use of a "clone panel". Birth Defects Orig Artic Ser. 1976; 12(7):238-40.
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Klobutcher LA, Nichols EA, Kucherlapati RS, Ruddle FH. Assignment of the gene for human adenosine kinase to chromosome 10 using a somatic cell hybrid clone panel. Birth Defects Orig Artic Ser. 1976; 12(7):171-4.
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Schacter B, Kucherlapati RS, Ruddle FH. Synteny of the loci for beta2-microglobulin and PKM2 in man-mouse somatic cell hybrid subclones. Cytogenet Cell Genet. 1976; 16(1-5):215-8.
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Kucherlapati RS, Faber HE, Poulik MD, Ruddle FH, Simithes O. Assignment of the gene for beta-2-microglogulin to human chromosome 15. Birth Defects Orig Artic Ser. 1976; 12(7):178-80.
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Shimizu N, Shimizu Y, Kucherlapati RS, Ruddle FH. Immunochemical detection of human enzymes in hybrid cells. Cell. 1976 Jan; 7(1):123-30.
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Willecke K, Reber T, Kucherlapati RS, Ruddle FH. Segregation of human mitochondrial thymidine thymidine kinase activity in human-mouse somatic cell hybrids. Birth Defects Orig Artic Ser. 1976; 12(7):252-5.
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McDougall JK, Gallimore PH, Dunn AR, Webb TP, Kucherlapati RS, Nichols EA, Ruddle FH. Mapping viral integration sites in somatic cell hybrids. Cytogenet Cell Genet. 1976; 16(1-5):206-10.
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Turner VS, Turner BM, Kucherlapati R, Ruddle FH, Hirschhorn K. Assignment of the human alpha-L-fucosidase gene locus to chromosome 1 by use of a "clone panel". Cytogenet Cell Genet. 1976; 16(1-5):238-40.
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Kucherlapati RS, Ruddle FH. Mammalian somatic hybrids and human gene mapping. Ann Intern Med. 1975 Oct; 83(4):553-60.
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Kucherlapati RS, Creagan RP, Nichols EA, Borgaonkar DS, Ruddle FH. Synteny relationships of four human genes: mannose phosphate isomerase to pyruvate kinase-3 and triose phophate isomerase to lactate dehydrogenase-B. Cytogenet Cell Genet. 1975; 14(3-6):364-7.
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Kucherlapati RS, Creagan RP, Nichols EA, Borgaonkar DS, Ruddle FH. Synteny relationships of four human genes: mannose phosphate isomerase to pyruvate kinase-3 and triose phosphate isomerase to lactate dehydrogenase-b. Birth Defects Orig Artic Ser. 1975; 11(3):194-7.
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Elsevier SM, Kucherlapati RS, Nichols EA, Willecke K, Creagan RP, Giles RE, McDougall JK, Ruddle FH. Assignment and regional localization of a gene coding for galactokinase to human chromosome 17q21-22. Birth Defects Orig Artic Ser. 1975; 11(3):117-9.
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Gilbert F, Kucherlapati R, Creagan RP, Murnane MJ, Darlington GJ, Ruddle FH. Tay-Sachs' and Sandhoff's diseases: the assignment of genes for hexosaminidase A and B to individual human chromosomes. Proc Natl Acad Sci U S A. 1975 Jan; 72(1):263-7.
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Elsevier SM, Kucherlapati RS, Nichols EA, Willecke K, Creagan RP, Giles RE, McDougall JK, Ruddle FH. Assigment and regional localization of a gene coding for galactokinase to human chromosome 17q21-22. Cytogenet Cell Genet. 1975; 14(3-6):287-9.
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Bias WB, Borgaonkar DS, Kucherlapati RS, Ruddle FH. Lymphocytotoxicity inhibition: a reliable method for HL-A typing of cultured cell lines. Birth Defects Orig Artic Ser. 1975; 11(3):71-6.
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McDougall JK, Elsevier SM, Kucherlapati RS, Ruddle FH. Regional localization of human genes in virus-induced uncoiler regions. Birth Defects Orig Artic Ser. 1975; 11(3):202-4.
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Satlin A, Kucherlapati R, Ruddle FH. Assignment of the gene for human uridine monophosphate kinase to chromosome 1 using somatic cell hybrid clone panels. Cytogenet Cell Genet. 1975; 15(3):146-52.
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Kucherlapati RS, Baker RM, Ruddle FH. Ouabain as a selective agent in the isolation of somatic cell hybrids. Birth Defects Orig Artic Ser. 1975; 11(3):192-3.
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Kucherlapati RS, Baker RM, Ruddle FH. Ouabain as a selective agent in the isolation of somatic cell hybrids. Cytogenet Cell Genet. 1975; 14(3-6):362-3.
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McDougall JK, Elsevier SM, Kucherlapati RS, Ruddle FH. Regional localization of human genes in virus-induced uncoiler regions. Cytogenet Cell Genet. 1975; 14(3-6):372-4.
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Kucherlapati RS, Hilwig I, Gropp A, Ruddle FH. Mammalian chromosome identification in interspecific hybride cells using "Hoechst 33258". Humangenetik. 1975; 27(1):9-14.
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Elsevier SM, Kucherlapati RS, Nichols EA, Creagan RP, Giles RE, Ruddle FH, Willecke K, McDougall JK. Assignment of the gene for galactokinase to human chromosome 17 and its regional localisation to band q21-22. Nature. 1974 Oct 18; 251(5476):633-6.
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Creagan RP, Carritt B, Chen S, Kucherlapati R, McMorris FA, Ricciuti F, Tan YH, Tischfield JA, Ruddle FH. Chromosome assignments of genes in man using mouse-human somatic cell hybrids: Cytoplasmic isocitrate dehydrogenase (IDH 1) and malate dehydrogenase (MDH 1) to chromosomes 2. Am J Hum Genet. 1974 Sep; 26(5):604-13.
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Ruddle FH, Kucherlapati RS. Hybrid cells and human genes. Sci Am. 1974 Jul; 231(1):36-44.
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Creagan RP, Carritt B, Chen S, Kucherlapati R, McMorris FA, Ricciuti F, Tan YH, Tischfield JA, Ruddle FH. Proceedings: Confirmation of the synteny of the human genes for cytoplasmic isocitrate dehydrogenase and cytoplasmic malate dehydrogenase and assignment to chromosome 2. Cytogenet Cell Genet. 1974; 13(1):79-82.
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Gilbert F, Kucherlapati R, Creagan R, Murnane MJ, Darlington GJ, Ruddle FH. Proceedings: Hexosaminidase B: assignment of a locus involved in its expression to chromosome 5 in man. Cytogenet Cell Genet. 1974; 13(1):93-5.
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Gilbert F, Kucherlapati R, Murnane MJ, Darlington GJ, Creagan R, Ruddle FH. Proceedings: Assignment of a locus involved in the expression of hexosaminidase A to chromosome 7 in man. Cytogenet Cell Genet. 1974; 13(1):96-6.
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Kucherlapati R, McDougall JK, Ruddle FH. Proceedings: Regional localization of the human genes for thymidine kinase, lactate dehydrogenase-A, and esterase-A. Cytogenet Cell Genet. 1974; 13(1):108-10.
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McDougall JK, Kucherlapati R, Ruddle FH. Localization and induction of the human thymidine kinase gene by adenovirus 12. Nat New Biol. 1973 Oct 10; 245(145):172-5.
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