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Keywords
Last Name
Institution

Mark A. Perrella, M.D.

TitleAssociate Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Women's Hospital
Pulmonary Medicine
75 Francis St
Boston MA 02115
Phone617/732-6809
Fax617/582-6148

 Overview 
 overview
Dr. Perrella is an Associate Professor of Medicine at Harvard Medical School and an Associate Physician in Pulmonary and Critical Care, and Newborn Medicine, at Brigham and Women’s Hospital in Boston, MA. Dr. Perrella has received a number of honors and awards throughout his career including the Internal Medicine Outstanding Achievement Award at the Mayo Graduate School of Medicine; Mayo Foundation Scholar in the Division of Thoracic Diseases and Internal Medicine; Mayo Alumni Association’s Donald C. Balfour Award for Meritorious Research; the Mayo Foundation Clinician Scholar Award; and election into the American Society for Clinical Investigation. Dr. Perrella is a National Institutes of Health (NIH) funded investigator, and he is devoted to the scientific peer review process including his involvement in serving on NIH study sections and his appointment as an Associate Editor of the American Journal of Respiratory Cell and Molecular Biology. The Perrella laboratory is interested in: 1) The regulation and biology of genes important for the modulation of inflammation and oxidative stress in systemic disease processes. A gene of particular interest is heme oxygenase-1, and its downstream product carbon monoxide, in mediating the pathobiology of sepsis and acute lung injury. 2) The regulation and biology of genes selectively expressed in muscle cells (smooth or striated). A recent focus has been the striated preferentially expressed gene (Speg) and its role in fetal heart development and function. 3) The commitment and differentiation of progenitor cells during the evolution of disease processes. The ultimate goal is to develop novel cell-based strategies for the treatment of cardiopulmonary and vascular diseases for patients of all ages, from premature infants to adults.


 Mentoring 
 completed student projects
In-vitro identification and characterization of CK murine lung stem cell
Summer, 06/01/11 - 08/26/11
In vitro identification and characterization of c-kit+ murine lung stem cells
Summer, 06/14/11 - 08/10/11

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Barnig C, Cernadas M, Dutile S, Liu X, Perrella MA, Kazani S, Wechsler ME, Israel E, Levy BD. Lipoxin a4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma. Sci Transl Med. 2013 Feb 27; 5(174):174ra26.
    View in: PubMed
  2. Hall SR, Tsoyi K, Ith B, Padera RF, Lederer JA, Wang Z, Liu X, Perrella MA. Mesenchymal stromal cells improve survival during sepsis in the absence of heme oxygenase-1: the importance of neutrophils. Stem Cells. 2013 Feb; 31(2):397-407.
    View in: PubMed
  3. Kajstura J, Rota M, Cappetta D, Ogórek B, Arranto C, Bai Y, Ferreira-Martins J, Signore S, Sanada F, Matsuda A, Kostyla J, Caballero MV, Fiorini C, D'Alessandro DA, Michler RE, del Monte F, Hosoda T, Perrella MA, Leri A, Buchholz BA, Loscalzo J, Anversa P. Cardiomyogenesis in the aging and failing human heart. Circulation. 2012 Oct 9; 126(15):1869-81.
    View in: PubMed
  4. Anversa P, Perrella MA, Kourembanas S, Choi AM, Loscalzo J. Regenerative pulmonary medicine: potential and promise, pitfalls and challenges. Eur J Clin Invest. 2012 Aug; 42(8):900-13.
    View in: PubMed
  5. Chung SW, Kwon MY, Kang YH, Chung HT, Lee SJ, Kim HP, Perrella MA. Transforming growth factor-ß1 suppression of endotoxin-induced heme oxygenase-1 in macrophages involves activation of Smad2 and downregulation of Ets-2. J Cell Physiol. 2012 Jan; 227(1):351-60.
    View in: PubMed
  6. Zhou X, Baron RM, Hardin M, Cho MH, Zielinski J, Hawrylkiewicz I, Sliwinski P, Hersh CP, Mancini JD, Lu K, Thibault D, Donahue AL, Klanderman BJ, Rosner B, Raby BA, Lu Q, Geldart AM, Layne MD, Perrella MA, Weiss ST, Choi AM, Silverman EK. Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP. Hum Mol Genet. 2012 Mar 15; 21(6):1325-35.
    View in: PubMed
  7. Kwon MY, Liu X, Lee SJ, Kang YH, Choi AM, Lee KU, Perrella MA, Chung SW. Nucleotide-binding oligomerization domain protein 2 deficiency enhances neointimal formation in response to vascular injury. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2441-7.
    View in: PubMed
  8. Fredenburgh LE, Velandia MM, Ma J, Olszak T, Cernadas M, Englert JA, Chung SW, Liu X, Begay C, Padera RF, Blumberg RS, Walsh SR, Baron RM, Perrella MA. Cyclooxygenase-2 deficiency leads to intestinal barrier dysfunction and increased mortality during polymicrobial sepsis. J Immunol. 2011 Nov 15; 187(10):5255-67.
    View in: PubMed
  9. Kajstura J, Rota M, Hall SR, Hosoda T, D'Amario D, Sanada F, Zheng H, Ogórek B, Rondon-Clavo C, Ferreira-Martins J, Matsuda A, Arranto C, Goichberg P, Giordano G, Haley KJ, Bardelli S, Rayatzadeh H, Liu X, Quaini F, Liao R, Leri A, Perrella MA, Loscalzo J, Anversa P. Evidence for human lung stem cells. N Engl J Med. 2011 May 12; 364(19):1795-806.
    View in: PubMed
  10. Baron RM, Lopez-Guzman S, Riascos DF, Macias AA, Layne MD, Cheng G, Harris C, Chung SW, Reeves R, von Andrian UH, Perrella MA. Distamycin A inhibits HMGA1-binding to the P-selectin promoter and attenuates lung and liver inflammation during murine endotoxemia. PLoS One. 2010; 5(5):e10656.
    View in: PubMed
  11. Hung CC, Liu X, Kwon MY, Kang YH, Chung SW, Perrella MA. Regulation of heme oxygenase-1 gene by peptidoglycan involves the interaction of Elk-1 and C/EBPalpha to increase expression. Am J Physiol Lung Cell Mol Physiol. 2010 Jun; 298(6):L870-9.
    View in: PubMed
  12. Grant MA, Baron RM, Macias AA, Layne MD, Perrella MA, Rigby AC. Netropsin improves survival from endotoxaemia by disrupting HMGA1 binding to the NOS2 promoter. Biochem J. 2009 Feb 15; 418(1):103-12.
    View in: PubMed
  13. Fredenburgh LE, Ma J, Perrella MA. Cyclooxygenase-2 inhibition and hypoxia-induced pulmonary hypertension: effects on pulmonary vascular remodeling and contractility. Trends Cardiovasc Med. 2009 Feb; 19(2):31-7.
    View in: PubMed
  14. Schissel SL, Dunsmore SE, Liu X, Shine RW, Perrella MA, Layne MD. Aortic carboxypeptidase-like protein is expressed in fibrotic human lung and its absence protects against bleomycin-induced lung fibrosis. Am J Pathol. 2009 Mar; 174(3):818-28.
    View in: PubMed
  15. Liu X, Ramjiganesh T, Chen YH, Chung SW, Hall SR, Schissel SL, Padera RF, Liao R, Ackerman KG, Kajstura J, Leri A, Anversa P, Yet SF, Layne MD, Perrella MA. Disruption of striated preferentially expressed gene locus leads to dilated cardiomyopathy in mice. Circulation. 2009 Jan 20; 119(2):261-8.
    View in: PubMed
  16. Takamiya R, Hung CC, Hall SR, Fukunaga K, Nagaishi T, Maeno T, Owen C, Macias AA, Fredenburgh LE, Ishizaka A, Blumberg RS, Baron RM, Perrella MA. High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice. Am J Respir Cell Mol Biol. 2009 Aug; 41(2):129-35.
    View in: PubMed
  17. Chung SW, Hall SR, Perrella MA. Role of haem oxygenase-1 in microbial host defence. Cell Microbiol. 2009 Feb; 11(2):199-207.
    View in: PubMed
  18. Geraldes P, Yagi K, Ohshiro Y, He Z, Maeno Y, Yamamoto-Hiraoka J, Rask-Madsen C, Chung SW, Perrella MA, King GL. Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway. J Biol Chem. 2008 Dec 5; 283(49):34327-36.
    View in: PubMed
  19. Fredenburgh LE, Liang OD, Macias AA, Polte TR, Liu X, Riascos DF, Chung SW, Schissel SL, Ingber DE, Mitsialis SA, Kourembanas S, Perrella MA. Absence of cyclooxygenase-2 exacerbates hypoxia-induced pulmonary hypertension and enhances contractility of vascular smooth muscle cells. Circulation. 2008 Apr 22; 117(16):2114-22.
    View in: PubMed
  20. Takamiya R, Baron RM, Yet SF, Layne MD, Perrella MA. High mobility group A1 protein mediates human nitric oxide synthase 2 gene expression. FEBS Lett. 2008 Mar 5; 582(5):810-4.
    View in: PubMed
  21. Chung SW, Liu X, Macias AA, Baron RM, Perrella MA. Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice. J Clin Invest. 2008 Jan; 118(1):239-47.
    View in: PubMed
  22. Lee PS, Waxman AB, Cotich KL, Chung SW, Perrella MA, Stossel TP. Plasma gelsolin is a marker and therapeutic agent in animal sepsis. Crit Care Med. 2007 Mar; 35(3):849-55.
    View in: PubMed
  23. Perrella MA. Heme oxygenase-1: a multifaceted triple-threat molecule. Am J Respir Cell Mol Biol. 2007 Feb; 36(2):137.
    View in: PubMed
  24. Stocker R, Perrella MA. Heme oxygenase-1: a novel drug target for atherosclerotic diseases? Circulation. 2006 Nov 14; 114(20):2178-89.
    View in: PubMed
  25. Fredenburgh LE, Perrella MA, Mitsialis SA. The role of heme oxygenase-1 in pulmonary disease. Am J Respir Cell Mol Biol. 2007 Feb; 36(2):158-65.
    View in: PubMed
  26. Chung SW, Chen YH, Yet SF, Layne MD, Perrella MA. Endotoxin-induced down-regulation of Elk-3 facilitates heme oxygenase-1 induction in macrophages. J Immunol. 2006 Feb 15; 176(4):2414-20.
    View in: PubMed
  27. Baron RM, Baron MJ, Perrella MA. Pathobiology of sepsis: are we still asking the same questions? Am J Respir Cell Mol Biol. 2006 Feb; 34(2):129-34.
    View in: PubMed
  28. Liu X, Pachori AS, Ward CA, Davis JP, Gnecchi M, Kong D, Zhang L, Murduck J, Yet SF, Perrella MA, Pratt RE, Dzau VJ, Melo LG. Heme oxygenase-1 (HO-1) inhibits postmyocardial infarct remodeling and restores ventricular function. FASEB J. 2006 Feb; 20(2):207-16.
    View in: PubMed
  29. Wang Y, Baron RM, Zhu G, Joo M, Christman JW, Silverman ES, Perrella MA, Riese RJ, Cernadas M. PU.1 regulates cathepsin S expression in professional APCs. J Immunol. 2006 Jan 1; 176(1):275-83.
    View in: PubMed
  30. Fredenburgh LE, Baron RM, Carvajal IM, Mouded M, Macias AA, Ith B, Perrella MA. Absence of heme oxygenase-1 expression in the lung parenchyma exacerbates endotoxin-induced acute lung injury and decreases surfactant protein-B levels. Cell Mol Biol (Noisy-le-grand). 2005 Oct 3; 51(5):513-20.
    View in: PubMed
  31. Ith B, Wei J, Yet SF, Perrella MA, Layne MD. Aortic carboxypeptidase-like protein is expressed in collagen-rich tissues during mouse embryonic development. Gene Expr Patterns. 2005 Apr; 5(4):533-7.
    View in: PubMed
  32. Chung SW, Chen YH, Perrella MA. Role of Ets-2 in the regulation of heme oxygenase-1 by endotoxin. J Biol Chem. 2005 Feb 11; 280(6):4578-84.
    View in: PubMed
  33. Bishop A, Yet SF, Lee ME, Perrella MA, Demple B. A key role for heme oxygenase-1 in nitric oxide resistance in murine motor neurons and glia. Biochem Biophys Res Commun. 2004 Dec 3; 325(1):3-9.
    View in: PubMed
  34. Ejima K, Perrella MA. Alteration in heme oxygenase-1 and nitric oxide synthase-2 gene expression during endotoxemia in cyclooxygenase-2-deficient mice. Antioxid Redox Signal. 2004 Oct; 6(5):850-7.
    View in: PubMed
  35. Baron RM, Carvajal IM, Liu X, Okabe RO, Fredenburgh LE, Macias AA, Chen YH, Ejima K, Layne MD, Perrella MA. Reduction of nitric oxide synthase 2 expression by distamycin A improves survival from endotoxemia. J Immunol. 2004 Sep 15; 173(6):4147-53.
    View in: PubMed
  36. Baron RM, Carvajal IM, Fredenburgh LE, Liu X, Porrata Y, Cullivan ML, Haley KJ, Sonna LA, De Sanctis GT, Ingenito EP, Perrella MA. Nitric oxide synthase-2 down-regulates surfactant protein-B expression and enhances endotoxin-induced lung injury in mice. FASEB J. 2004 Aug; 18(11):1276-8.
    View in: PubMed
  37. Agrawal RS, Muangman S, Layne MD, Melo L, Perrella MA, Lee RT, Zhang L, Lopez-Ilasaca M, Dzau VJ. Pre-emptive gene therapy using recombinant adeno-associated virus delivery of extracellular superoxide dismutase protects heart against ischemic reperfusion injury, improves ventricular function and prolongs survival. Gene Ther. 2004 Jun; 11(12):962-9.
    View in: PubMed
  38. Chung SW, Perrella MA. Role of HO-1 in renoprotection: location, location, location. Kidney Int. 2004 May; 65(5):1968-9.
    View in: PubMed
  39. Kong D, Melo LG, Mangi AA, Zhang L, Lopez-Ilasaca M, Perrella MA, Liew CC, Pratt RE, Dzau VJ. Enhanced inhibition of neointimal hyperplasia by genetically engineered endothelial progenitor cells. Circulation. 2004 Apr 13; 109(14):1769-75.
    View in: PubMed
  40. Chen YH, Layne MD, Chung SW, Ejima K, Baron RM, Yet SF, Perrella MA. Elk-3 is a transcriptional repressor of nitric-oxide synthase 2. J Biol Chem. 2003 Oct 10; 278(41):39572-7.
    View in: PubMed
  41. Yet SF, Layne MD, Liu X, Chen YH, Ith B, Sibinga NE, Perrella MA. Absence of heme oxygenase-1 exacerbates atherosclerotic lesion formation and vascular remodeling. FASEB J. 2003 Sep; 17(12):1759-61.
    View in: PubMed
  42. Ejima K, Layne MD, Carvajal IM, Kritek PA, Baron RM, Chen YH, Vom Saal J, Levy BD, Yet SF, Perrella MA. Cyclooxygenase-2-deficient mice are resistant to endotoxin-induced inflammation and death. FASEB J. 2003 Jul; 17(10):1325-7.
    View in: PubMed
  43. Chen YH, Yet SF, Perrella MA. Role of heme oxygenase-1 in the regulation of blood pressure and cardiac function. Exp Biol Med (Maywood). 2003 May; 228(5):447-53.
    View in: PubMed
  44. Perrella MA, Yet SF. Role of heme oxygenase-1 in cardiovascular function. Curr Pharm Des. 2003; 9(30):2479-87.
    View in: PubMed
  45. Ejima K, Layne MD, Carvajal IM, Nanri H, Ith B, Yet SF, Perrella MA. Modulation of the thioredoxin system during inflammatory responses and its effect on heme oxygenase-1 expression. Antioxid Redox Signal. 2002 Aug; 4(4):569-75.
    View in: PubMed
  46. Storm van's Gravesande K, Layne MD, Ye Q, Le L, Baron RM, Perrella MA, Santambrogio L, Silverman ES, Riese RJ. IFN regulatory factor-1 regulates IFN-gamma-dependent cathepsin S expression. J Immunol. 2002 May 1; 168(9):4488-94.
    View in: PubMed
  47. Layne MD, Yet SF, Maemura K, Hsieh CM, Liu X, Ith B, Lee ME, Perrella MA. Characterization of the mouse aortic carboxypeptidase-like protein promoter reveals activity in differentiated and dedifferentiated vascular smooth muscle cells. Circ Res. 2002 Apr 5; 90(6):728-36.
    View in: PubMed
  48. Melo LG, Agrawal R, Zhang L, Rezvani M, Mangi AA, Ehsan A, Griese DP, Dell'Acqua G, Mann MJ, Oyama J, Yet SF, Layne MD, Perrella MA, Dzau VJ. Gene therapy strategy for long-term myocardial protection using adeno-associated virus-mediated delivery of heme oxygenase gene. Circulation. 2002 Feb 5; 105(5):602-7.
    View in: PubMed
  49. Yet SF, Melo LG, Layne MD, Perrella MA. Heme oxygenase 1 in regulation of inflammation and oxidative damage. Methods Enzymol. 2002; 353:163-76.
    View in: PubMed
  50. Carvajal IM, Baron RM, Perrella MA. High-mobility group-I/Y proteins: potential role in the pathophysiology of critical illnesses. Crit Care Med. 2002 Jan; 30(1 Suppl):S36-42.
    View in: PubMed
  51. Maemura K, Layne MD, Watanabe M, Perrell MA, Nagai R, Lee ME. Molecular mechanisms of morning onset of myocardial infarction. Ann N Y Acad Sci. 2001 Dec; 947:398-402.
    View in: PubMed
  52. Chen YH, Layne MD, Watanabe M, Yet SF, Perrella MA. Upstream stimulatory factors regulate aortic preferentially expressed gene-1 expression in vascular smooth muscle cells. J Biol Chem. 2001 Dec 14; 276(50):47658-63.
    View in: PubMed
  53. Layne MD, Patel A, Chen YH, Rebel VI, Carvajal IM, Pellacani A, Ith B, Zhao D, Schreiber BM, Yet SF, Lee ME, Storch J, Perrella MA. Role of macrophage-expressed adipocyte fatty acid binding protein in the development of accelerated atherosclerosis in hypercholesterolemic mice. FASEB J. 2001 Dec; 15(14):2733-5.
    View in: PubMed
  54. Perrella MA, Pellacani A, Layne MD, Patel A, Zhao D, Schreiber BM, Storch J, Feinberg MW, Hsieh CM, Haber E, Lee ME. Absence of adipocyte fatty acid binding protein prevents the development of accelerated atherosclerosis in hypercholesterolemic mice. FASEB J. 2001 Aug; 15(10):1774-6.
    View in: PubMed
  55. Layne MD, Yet SF, Maemura K, Hsieh CM, Bernfield M, Perrella MA, Lee ME. Impaired abdominal wall development and deficient wound healing in mice lacking aortic carboxypeptidase-like protein. Mol Cell Biol. 2001 Aug; 21(15):5256-61.
    View in: PubMed
  56. Yet SF, Tian R, Layne MD, Wang ZY, Maemura K, Solovyeva M, Ith B, Melo LG, Zhang L, Ingwall JS, Dzau VJ, Lee ME, Perrella MA. Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice. Circ Res. 2001 Jul 20; 89(2):168-73.
    View in: PubMed
  57. Minamino T, Christou H, Hsieh CM, Liu Y, Dhawan V, Abraham NG, Perrella MA, Mitsialis SA, Kourembanas S. Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8798-803.
    View in: PubMed
  58. Wiesel P, Patel AP, Carvajal IM, Wang ZY, Pellacani A, Maemura K, DiFonzo N, Rennke HG, Layne MD, Yet SF, Lee ME, Perrella MA. Exacerbation of chronic renovascular hypertension and acute renal failure in heme oxygenase-1-deficient mice. Circ Res. 2001 May 25; 88(10):1088-94.
    View in: PubMed
  59. Fukumoto S, Hsieh CM, Maemura K, Layne MD, Yet SF, Lee KH, Matsui T, Rosenzweig A, Taylor WG, Rubin JS, Perrella MA, Lee ME. Akt participation in the Wnt signaling pathway through Dishevelled. J Biol Chem. 2001 May 18; 276(20):17479-83.
    View in: PubMed
  60. Pellacani A, Wiesel P, Razavi S, Vasilj V, Feinberg MW, Chin MT, Reeves R, Perrella MA. Down-regulation of high mobility group-I(Y) protein contributes to the inhibition of nitric-oxide synthase 2 by transforming growth factor-beta1. J Biol Chem. 2001 Jan 12; 276(2):1653-9.
    View in: PubMed
  61. Wiesel P, Patel AP, DiFonzo N, Marria PB, Sim CU, Pellacani A, Maemura K, LeBlanc BW, Marino K, Doerschuk CM, Yet SF, Lee ME, Perrella MA. Endotoxin-induced mortality is related to increased oxidative stress and end-organ dysfunction, not refractory hypotension, in heme oxygenase-1-deficient mice. Circulation. 2000 Dec 12; 102(24):3015-22.
    View in: PubMed
  62. Hsieh CM, Fukumoto S, Layne MD, Maemura K, Charles H, Patel A, Perrella MA, Lee ME. Striated muscle preferentially expressed genes alpha and beta are two serine/threonine protein kinases derived from the same gene as the aortic preferentially expressed gene-1. J Biol Chem. 2000 Nov 24; 275(47):36966-73.
    View in: PubMed
  63. Maemura K, de la Monte SM, Chin MT, Layne MD, Hsieh CM, Yet SF, Perrella MA, Lee ME. CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression. J Biol Chem. 2000 Nov 24; 275(47):36847-51.
    View in: PubMed
  64. Werner F, Jain MK, Feinberg MW, Sibinga NE, Pellacani A, Wiesel P, Chin MT, Topper JN, Perrella MA, Lee ME. Transforming growth factor-beta 1 inhibition of macrophage activation is mediated via Smad3. J Biol Chem. 2000 Nov 24; 275(47):36653-8.
    View in: PubMed
  65. Rudders S, Gaspar J, Madore R, Voland C, Grall F, Patel A, Pellacani A, Perrella MA, Libermann TA, Oettgen P. ESE-1 is a novel transcriptional mediator of inflammation that interacts with NF-kappa B to regulate the inducible nitric-oxide synthase gene. J Biol Chem. 2001 Feb 2; 276(5):3302-9.
    View in: PubMed
  66. DiChiara MR, Kiely JM, Gimbrone MA, Lee ME, Perrella MA, Topper JN. Inhibition of E-selectin gene expression by transforming growth factor beta in endothelial cells involves coactivator integration of Smad and nuclear factor kappaB-mediated signals. J Exp Med. 2000 Sep 4; 192(5):695-704.
    View in: PubMed
  67. Feinberg MW, Jain MK, Werner F, Sibinga NE, Wiesel P, Wang H, Topper JN, Perrella MA, Lee ME. Transforming growth factor-beta 1 inhibits cytokine-mediated induction of human metalloelastase in macrophages. J Biol Chem. 2000 Aug 18; 275(33):25766-73.
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  68. Wiesel P, Foster LC, Pellacani A, Layne MD, Hsieh CM, Huggins GS, Strauss P, Yet SF, Perrella MA. Thioredoxin facilitates the induction of heme oxygenase-1 in response to inflammatory mediators. J Biol Chem. 2000 Aug 11; 275(32):24840-6.
    View in: PubMed
  69. Christou H, Morita T, Hsieh CM, Koike H, Arkonac B, Perrella MA, Kourembanas S. Prevention of hypoxia-induced pulmonary hypertension by enhancement of endogenous heme oxygenase-1 in the rat. Circ Res. 2000 Jun 23; 86(12):1224-9.
    View in: PubMed
  70. Foster LC, Wiesel P, Huggins GS, Pañares R, Chin MT, Pellacani A, Perrella MA. Role of activating protein-1 and high mobility group-I(Y) protein in the induction of CD44 gene expression by interleukin-1beta in vascular smooth muscle cells. FASEB J. 2000 Feb; 14(2):368-78.
    View in: PubMed
  71. Chin MT, Pellacani A, Hsieh CM, Lin SS, Jain MK, Patel A, Huggins GS, Reeves R, Perrella MA, Lee ME. Induction of high mobility group I architectural transcription factors in proliferating vascular smooth muscle in vivo and in vitro. J Mol Cell Cardiol. 1999 Dec; 31(12):2199-205.
    View in: PubMed
  72. Maemura K, Hsieh CM, Jain MK, Fukumoto S, Layne MD, Liu Y, Kourembanas S, Yet SF, Perrella MA, Lee ME. Generation of a dominant-negative mutant of endothelial PAS domain protein 1 by deletion of a potent C-terminal transactivation domain. J Biol Chem. 1999 Oct 29; 274(44):31565-70.
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  73. Hsieh CM, Yet SF, Layne MD, Watanabe M, Hong AM, Perrella MA, Lee ME. Genomic cloning and promoter analysis of aortic preferentially expressed gene-1. Identification of a vascular smooth muscle-specific promoter mediated by an E box motif. J Biol Chem. 1999 May 14; 274(20):14344-51.
    View in: PubMed
  74. Sibinga NE, Wang H, Perrella MA, Endege WO, Patterson C, Yoshizumi M, Haber E, Lee ME. Interferon-gamma-mediated inhibition of cyclin A gene transcription is independent of individual cis-acting elements in the cyclin A promoter. J Biol Chem. 1999 Apr 23; 274(17):12139-46.
    View in: PubMed
  75. Yet SF, Perrella MA, Layne MD, Hsieh CM, Maemura K, Kobzik L, Wiesel P, Christou H, Kourembanas S, Lee ME. Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice. J Clin Invest. 1999 Apr; 103(8):R23-9.
    View in: PubMed
  76. Perrella MA, Pellacani A, Wiesel P, Chin MT, Foster LC, Ibanez M, Hsieh CM, Reeves R, Yet SF, Lee ME. High mobility group-I(Y) protein facilitates nuclear factor-kappaB binding and transactivation of the inducible nitric-oxide synthase promoter/enhancer. J Biol Chem. 1999 Mar 26; 274(13):9045-52.
    View in: PubMed
  77. Pellacani A, Chin MT, Wiesel P, Ibanez M, Patel A, Yet SF, Hsieh CM, Paulauskis JD, Reeves R, Lee ME, Perrella MA. Induction of high mobility group-I(Y) protein by endotoxin and interleukin-1beta in vascular smooth muscle cells. Role in activation of inducible nitric oxide synthase. J Biol Chem. 1999 Jan 15; 274(3):1525-32.
    View in: PubMed
  78. Pellacani A, Wiesel P, Sharma A, Foster LC, Huggins GS, Yet SF, Perrella MA. Induction of heme oxygenase-1 during endotoxemia is downregulated by transforming growth factor-beta1. Circ Res. 1998 Aug 24; 83(4):396-403.
    View in: PubMed
  79. Foster LC, Arkonac BM, Sibinga NE, Shi C, Perrella MA, Haber E. Regulation of CD44 gene expression by the proinflammatory cytokine interleukin-1beta in vascular smooth muscle cells. J Biol Chem. 1998 Aug 7; 273(32):20341-6.
    View in: PubMed
  80. Layne MD, Endege WO, Jain MK, Yet SF, Hsieh CM, Chin MT, Perrella MA, Blanar MA, Haber E, Lee ME. Aortic carboxypeptidase-like protein, a novel protein with discoidin and carboxypeptidase-like domains, is up-regulated during vascular smooth muscle cell differentiation. J Biol Chem. 1998 Jun 19; 273(25):15654-60.
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  81. Yet SF, Folta SC, Jain MK, Hsieh CM, Maemura K, Layne MD, Zhang D, Marria PB, Yoshizumi M, Chin MT, Perrella MA, Lee ME. Molecular cloning, characterization, and promoter analysis of the mouse Crp2/SmLim gene. Preferential expression of its promoter in the vascular smooth muscle cells of transgenic mice. J Biol Chem. 1998 Apr 24; 273(17):10530-7.
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  82. Chin MT, Pellacani A, Wang H, Lin SS, Jain MK, Perrella MA, Lee ME. Enhancement of serum-response factor-dependent transcription and DNA binding by the architectural transcription factor HMG-I(Y). J Biol Chem. 1998 Apr 17; 273(16):9755-60.
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  83. Arkonac BM, Foster LC, Sibinga NE, Patterson C, Lai K, Tsai JC, Lee ME, Perrella MA, Haber E. Vascular endothelial growth factor induces heparin-binding epidermal growth factor-like growth factor in vascular endothelial cells. J Biol Chem. 1998 Feb 20; 273(8):4400-5.
    View in: PubMed
  84. Yet SF, McA'Nulty MM, Folta SC, Yen HW, Yoshizumi M, Hsieh CM, Layne MD, Chin MT, Wang H, Perrella MA, Jain MK, Lee ME. Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains. J Biol Chem. 1998 Jan 9; 273(2):1026-31.
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  85. Perrella MA, Jain MK, Lee ME. Role of TGF-beta in vascular development and vascular reactivity. Miner Electrolyte Metab. 1998; 24(2-3):136-43.
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  86. Wang H, Yoshizumi M, Lai K, Tsai JC, Perrella MA, Haber E, Lee ME. Inhibition of growth and p21ras methylation in vascular endothelial cells by homocysteine but not cysteine. J Biol Chem. 1997 Oct 3; 272(40):25380-5.
    View in: PubMed
  87. Yoshizumi M, Wang H, Hsieh CM, Sibinga NE, Perrella MA, Lee ME. Down-regulation of the cyclin A promoter by transforming growth factor-beta1 is associated with a reduction in phosphorylated activating transcription factor-1 and cyclic AMP-responsive element-binding protein. J Biol Chem. 1997 Aug 29; 272(35):22259-64.
    View in: PubMed
  88. Sibinga NE, Foster LC, Hsieh CM, Perrella MA, Lee WS, Endege WO, Sage EH, Lee ME, Haber E. Collagen VIII is expressed by vascular smooth muscle cells in response to vascular injury. Circ Res. 1997 Apr; 80(4):532-41.
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  89. Yet SF, Pellacani A, Patterson C, Tan L, Folta SC, Foster L, Lee WS, Hsieh CM, Perrella MA. Induction of heme oxygenase-1 expression in vascular smooth muscle cells. A link to endotoxic shock. J Biol Chem. 1997 Feb 14; 272(7):4295-301.
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  90. Hsieh CM, Yoshizumi M, Endege WO, Kho CJ, Jain MK, Kashiki S, de los Santos R, Lee WS, Perrella MA, Lee ME. APEG-1, a novel gene preferentially expressed in aortic smooth muscle cells, is down-regulated by vascular injury. J Biol Chem. 1996 Jul 19; 271(29):17354-9.
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  91. Patterson C, Perrella MA, Endege WO, Yoshizumi M, Lee ME, Haber E. Downregulation of vascular endothelial growth factor receptors by tumor necrosis factor-alpha in cultured human vascular endothelial cells. J Clin Invest. 1996 Jul 15; 98(2):490-6.
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  92. Perrella MA, Patterson C, Tan L, Yet SF, Hsieh CM, Yoshizumi M, Lee ME. Suppression of interleukin-1beta-induced nitric-oxide synthase promoter/enhancer activity by transforming growth factor-beta1 in vascular smooth muscle cells. Evidence for mechanisms other than NF-kappaB. J Biol Chem. 1996 Jun 7; 271(23):13776-80.
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  93. Jain MK, Fujita KP, Hsieh CM, Endege WO, Sibinga NE, Yet SF, Kashiki S, Lee WS, Perrella MA, Haber E, Lee ME. Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells. J Biol Chem. 1996 Apr 26; 271(17):10194-9.
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  94. Perrella MA, Hsieh CM, Lee WS, Shieh S, Tsai JC, Patterson C, Lowenstein CJ, Long NC, Haber E, Shore S, Lee ME. Arrest of endotoxin-induced hypotension by transforming growth factor beta1. Proc Natl Acad Sci U S A. 1996 Mar 5; 93(5):2054-9.
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  95. Tsai JC, Jain M, Hsieh CM, Lee WS, Yoshizumi M, Patterson C, Perrella MA, Cooke C, Wang H, Haber E, Schlegel R, Lee ME. Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells. J Biol Chem. 1996 Feb 16; 271(7):3667-70.
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  96. Tsai JC, Wang H, Perrella MA, Yoshizumi M, Sibinga NE, Tan LC, Haber E, Chang TH, Schlegel R, Lee ME. Induction of cyclin A gene expression by homocysteine in vascular smooth muscle cells. J Clin Invest. 1996 Jan 1; 97(1):146-53.
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  97. Patterson C, Perrella MA, Hsieh CM, Yoshizumi M, Lee ME, Haber E. Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor. J Biol Chem. 1995 Sep 29; 270(39):23111-8.
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  98. Yoshizumi M, Hsieh CM, Zhou F, Tsai JC, Patterson C, Perrella MA, Lee ME. The ATF site mediates downregulation of the cyclin A gene during contact inhibition in vascular endothelial cells. Mol Cell Biol. 1995 Jun; 15(6):3266-72.
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  99. Yoshizumi M, Lee WS, Hsieh CM, Tsai JC, Li J, Perrella MA, Patterson C, Endege WO, Schlegel R, Lee ME. Disappearance of cyclin A correlates with permanent withdrawal of cardiomyocytes from the cell cycle in human and rat hearts. J Clin Invest. 1995 May; 95(5):2275-80.
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  100. Morita T, Perrella MA, Lee ME, Kourembanas S. Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP. Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1475-9.
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  101. Li J, Perrella MA, Tsai JC, Yet SF, Hsieh CM, Yoshizumi M, Patterson C, Endege WO, Zhou F, Lee ME. Induction of vascular endothelial growth factor gene expression by interleukin-1 beta in rat aortic smooth muscle cells. J Biol Chem. 1995 Jan 6; 270(1):308-12.
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  102. Perrella MA, Mäki T, Prasad S, Pimental D, Singh K, Takahashi N, Yoshizumi M, Alali A, Higashiyama S, Kelly RA, et al. Regulation of heparin-binding epidermal growth factor-like growth factor mRNA levels by hypertrophic stimuli in neonatal and adult rat cardiac myocytes. J Biol Chem. 1994 Oct 28; 269(43):27045-50.
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  103. Tan MS, Tsai JC, Lee YJ, Chen HC, Shin SJ, Lai YH, Perrella MA, Bianchi C, Higashiyama S, Endege W, et al. Induction of heparin-binding epidermal growth factor-like growth factor mRNA by protein kinase C activators. Kidney Int. 1994 Sep; 46(3):690-5.
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  104. Tsai JC, Perrella MA, Yoshizumi M, Hsieh CM, Haber E, Schlegel R, Lee ME. Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis. Proc Natl Acad Sci U S A. 1994 Jul 5; 91(14):6369-73.
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  105. Perrella MA, Yoshizumi M, Fen Z, Tsai JC, Hsieh CM, Kourembanas S, Lee ME. Transforming growth factor-beta 1, but not dexamethasone, down-regulates nitric-oxide synthase mRNA after its induction by interleukin-1 beta in rat smooth muscle cells. J Biol Chem. 1994 May 20; 269(20):14595-600.
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  106. O'Murchu B, Miller VM, Perrella MA, Burnett JC. Increased production of nitric oxide in coronary arteries during congestive heart failure. J Clin Invest. 1994 Jan; 93(1):165-71.
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  107. Wei CM, Heublein DM, Perrella MA, Lerman A, Rodeheffer RJ, McGregor CG, Edwards WD, Schaff HV, Burnett JC. Natriuretic peptide system in human heart failure. Circulation. 1993 Sep; 88(3):1004-9.
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  108. Yoshizumi M, Perrella MA, Burnett JC, Lee ME. Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life. Circ Res. 1993 Jul; 73(1):205-9.
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  109. Perrella MA, Aarhus LL, Heublein DM, Lewicki JA, Burnett JC. Biologic role of atrial natriuretic factor clearance receptor in congestive heart failure. Am J Physiol. 1993 Jul; 265(1 Pt 2):H401-8.
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  110. Haas JA, Khraibi AA, Perrella MA, Knox FG. Role of renal interstitial hydrostatic pressure in natriuresis of systemic nitric oxide inhibition. Am J Physiol. 1993 Mar; 264(3 Pt 2):F411-4.
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  111. Temizer DH, Yoshizumi M, Perrella MA, Susanni EE, Quertermous T, Lee ME. Induction of heparin-binding epidermal growth factor-like growth factor mRNA by phorbol ester and angiotensin II in rat aortic smooth muscle cells. J Biol Chem. 1992 Dec 5; 267(34):24892-6.
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  112. Sandok EK, Lerman A, Stingo AJ, Perrella MA, Gloviczki P, Burnett JC. Endothelin in a model of acute ischemic renal dysfunction: modulating action of atrial natriuretic factor. J Am Soc Nephrol. 1992 Aug; 3(2):196-202.
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  113. Perrella MA, Edell ES, Krowka MJ, Cortese DA, Burnett JC. Endothelium-derived relaxing factor in pulmonary and renal circulations during hypoxia. Am J Physiol. 1992 Jul; 263(1 Pt 2):R45-50.
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  114. Perrella MA, Schwab TR, O'Murchu B, Redfield MM, Wei CM, Edwards BS, Burnett JC. Cardiac atrial natriuretic factor during evolution of congestive heart failure. Am J Physiol. 1992 Apr; 262(4 Pt 2):H1248-55.
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  115. Utz JP, Perrella MA, Rosenow EC. Lung biopsy. Adv Intern Med. 1992; 37:337-61.
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  116. Margulies KB, Perrella MA, McKinley LJ, Burnett JC. Angiotensin inhibition potentiates the renal responses to neutral endopeptidase inhibition in dogs with congestive heart failure. J Clin Invest. 1991 Nov; 88(5):1636-42.
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  117. Perrella MA, Margulies KB, Burnett JC. Pathophysiology of congestive heart failure: role of atrial natriuretic factor and therapeutic implications. Can J Physiol Pharmacol. 1991 Oct; 69(10):1576-81.
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  118. Perrella MA, Smith HC, Khandheria BK. Pseudoaneurysm of the aortic root diagnosed by noninvasive imaging: report of a case. J Am Soc Echocardiogr. 1991 Sep-Oct; 4(5):499-502.
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  119. Perrella MA, Hildebrand FL, Margulies KB, Burnett JC. Endothelium-derived relaxing factor in regulation of basal cardiopulmonary and renal function. Am J Physiol. 1991 Aug; 261(2 Pt 2):R323-8.
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  120. Perrella MA, Margulies KB, Wei CM, Aarhus LL, Heublein DM, Burnett JC. Pulmonary and urinary clearance of atrial natriuretic factor in acute congestive heart failure in dogs. J Clin Invest. 1991 May; 87(5):1649-55.
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  121. Margulies KB, Heublein DM, Perrella MA, Burnett JC. ANF-mediated renal cGMP generation in congestive heart failure. Am J Physiol. 1991 Apr; 260(4 Pt 2):F562-8.
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  122. Margulies KB, Hildebrand FL, Lerman A, Perrella MA, Burnett JC. Increased endothelin in experimental heart failure. Circulation. 1990 Dec; 82(6):2226-30.
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  123. Lerman A, Hildebrand FL, Margulies KB, O'Murchu B, Perrella MA, Heublein DM, Schwab TR, Burnett JC. Endothelin: a new cardiovascular regulatory peptide. Mayo Clin Proc. 1990 Nov; 65(11):1441-55.
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