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John A F Zupancic, Sc.D., M.D.

TitleAssociate Professor of Pediatrics
InstitutionBeth Israel Deaconess Medical Center
DepartmentPediatrics
AddressBeth Israel Deaconess Med Ctr
Neonatology, Rose 318
330 Brookline Ave
Boston MA 02215
Phone617/355-7260
Fax617/667-7040

 Biography 
 awards and honors
2004 - Merton R. Bernfield Mentoring Award
2010 - John M. Eisenberg Excellence in Mentorship Award

 Overview 
 overview
Dr. Zupancic is Associate Professor of Pediatrics at Harvard Medical School and Director of the Harvard Neonatal-Perinatal Medicine Fellowship Program. His research and consulting work seek to improve the efficiency with which scarce resources are used in improving the health of children, and in particular, newborns. He has focused his efforts on performing and improving the validity of economic evaluations alongside neonatal clinical trials. Economic evaluations currently underway by Dr. Zupancic and colleagues alongside multi-center clinical trials include i) donor milk for improvement of neurodevelopmental outcomes; ii) high versus low oxygen saturation thresholds for the prevention of retinopathy of prematurity; iii) non-invasive ventilation for the reduction of chronic lung disease in premature infants; and iv) telephone support for treatment of post-partum depression. A second approach makes use of computer modeling to determine best practice when evidence is currently lacking or where empirical studies are infeasible.

In addition to his research work, Dr. Zupancic served as leader of the Value Initiative for the Vermont Oxford Network’s Neonatal Intensive Care Quality Improvement Collaborative and is currently the District One Representative to the American Academy of Pediatrics Section on Perinatal Pediatrics Executive Committee. He is a recipient of the Merton R. Bernfield Award for Excellence in Mentoring from the Harvard Medical School Division of Newborn Medicine and the John M. Eisenberg Award for Excellence in Mentorship from the Agency for Healthcare Research and Quality.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Escobar GJ, Puopolo KM, Wi S, Turk BJ, Kuzniewicz MW, Walsh EM, Newman TB, Zupancic J, Lieberman E, Draper D. Stratification of risk of early-onset sepsis in newborns >=34 weeks' gestation. Pediatrics. 2014 Jan; 133(1):30-6.
    View in: PubMed
  2. Gupta M, Ringer S, Tess A, Hansen A, Zupancic J. Developing a quality and safety curriculum for fellows: lessons learned from a neonatology fellowship program. Acad Pediatr. 2014 Jan-Feb; 14(1):47-53.
    View in: PubMed
  3. Sherenian M, Profit J, Schmidt B, Suh S, Xiao R, Zupancic JA, Demauro SB. Nurse-to-Patient Ratios and Neonatal Outcomes: A Brief Systematic Review. Neonatology. 2013; 104(3):179-83.
    View in: PubMed
  4. Dukhovny D, Dennis CL, Hodnett E, Weston J, Stewart DE, Mao W, Zupancic JA. Prospective Economic Evaluation of a Peer Support Intervention for Prevention of Postpartum Depression among High-Risk Women in Ontario, Canada. Am J Perinatol. 2013 Sep; 30(8):631-42.
    View in: PubMed
  5. Profit J, Zupancic JA, Gould JB, Pietz K, Kowalkowski MA, Draper D, Hysong SJ, Petersen LA. Correlation of neonatal intensive care unit performance across multiple measures of quality of care. JAMA Pediatr. 2013 Jan 1; 167(1):47-54.
    View in: PubMed
  6. Kirpalani H, Zupancic JA. Do transfusions cause necrotizing enterocolitis? The complementary role of randomized trials and observational studies. Semin Perinatol. 2012 Aug; 36(4):269-76.
    View in: PubMed
  7. Profit J, Gould JB, Draper D, Zupancic JA, Kowalkowski MA, Woodard L, Pietz K, Petersen LA. Variations in definitions of mortality have little influence on neonatal intensive care unit performance ratings. J Pediatr. 2013 Jan; 162(1):50-55.e2.
    View in: PubMed
  8. Dennis CL, Ravitz P, Grigoriadis S, Jovellanos M, Hodnett E, Ross L, Zupancic J. The effect of telephone-based interpersonal psychotherapy for the treatment of postpartum depression: study protocol for a randomized controlled trial. Trials. 2012; 13:38.
    View in: PubMed
  9. Guillén U, DeMauro S, Ma L, Zupancic J, Roberts R, Schmidt B, Kirpalani H. Relationship between attrition and neurodevelopmental impairment rates in extremely preterm infants at 18 to 24 months: a systematic review. Arch Pediatr Adolesc Med. 2012 Feb; 166(2):178-84.
    View in: PubMed
  10. Smith VC, Dukhovny D, Zupancic JA, Gates HB, Pursley DM. Neonatal intensive care unit discharge preparedness: primary care implications. Clin Pediatr (Phila). 2012 May; 51(5):454-61.
    View in: PubMed
  11. Dukhovny D, Dukhovny S, Pursley DM, Escobar GJ, McCormick MC, Mao WY, Zupancic JA. The impact of maternal characteristics on the moderately premature infant: an antenatal maternal transport clinical prediction rule. J Perinatol. 2012 Jul; 32(7):532-8.
    View in: PubMed
  12. Guillén Ú, Suh S, Munson D, Posencheg M, Truitt E, Zupancic JA, Gafni A, Kirpalani H. Development and pretesting of a decision-aid to use when counseling parents facing imminent extreme premature delivery. J Pediatr. 2012 Mar; 160(3):382-7.
    View in: PubMed
  13. Puopolo KM, Draper D, Wi S, Newman TB, Zupancic J, Lieberman E, Smith M, Escobar GJ. Estimating the probability of neonatal early-onset infection on the basis of maternal risk factors. Pediatrics. 2011 Nov; 128(5):e1155-63.
    View in: PubMed
  14. Kamholz KL, Dukhovny D, Kirpalani H, Whyte RK, Roberts RS, Wang N, Mao W, Zupancic JA. Economic evaluation alongside the Premature Infants in Need of Transfusion randomised controlled trial. Arch Dis Child Fetal Neonatal Ed. 2012 Mar; 97(2):F93-8.
    View in: PubMed
  15. Guillen U, DeMauro S, Ma L, Zupancic J, Wang E, Gafni A, Kirpalani H. Survival rates in extremely low birthweight infants depend on the denominator: avoiding potential for bias by specifying denominators. Am J Obstet Gynecol. 2011 Oct; 205(4):329.e1-7.
    View in: PubMed
  16. Profit J, Gould JB, Zupancic JA, Stark AR, Wall KM, Kowalkowski MA, Mei M, Pietz K, Thomas EJ, Petersen LA. Formal selection of measures for a composite index of NICU quality of care: Baby-MONITOR. J Perinatol. 2011 Nov; 31(11):702-10.
    View in: PubMed
  17. Belfort MB, Zupancic JA, Riera KM, Turner JH, Prosser LA. Health state preferences associated with weight status in children and adolescents. BMC Pediatr. 2011; 11:12.
    View in: PubMed
  18. McCormick MC, Litt JS, Smith VC, Zupancic JA. Prematurity: an overview and public health implications. Annu Rev Public Health. 2011; 32:367-79.
    View in: PubMed
  19. Eichenwald EC, Zupancic JA, Mao WY, Richardson DK, McCormick MC, Escobar GJ. Variation in diagnosis of apnea in moderately preterm infants predicts length of stay. Pediatrics. 2011 Jan; 127(1):e53-8.
    View in: PubMed
  20. Dukhovny D, Lorch SA, Schmidt B, Doyle LW, Kok JH, Roberts RS, Kamholz KL, Wang N, Mao W, Zupancic JA. Economic evaluation of caffeine for apnea of prematurity. Pediatrics. 2011 Jan; 127(1):e146-55.
    View in: PubMed
  21. Profit J, Lee D, Zupancic JA, Papile L, Gutierrez C, Goldie SJ, Gonzalez-Pier E, Salomon JA. Clinical benefits, costs, and cost-effectiveness of neonatal intensive care in Mexico. PLoS Med. 2010; 7(12):e1000379.
    View in: PubMed
  22. Profit J, Petersen LA, McCormick MC, Escobar GJ, Coleman-Phox K, Zheng Z, Pietz K, Zupancic JA. Patient-to-nurse ratios and outcomes of moderately preterm infants. Pediatrics. 2010 Feb; 125(2):320-6.
    View in: PubMed
  23. Dammann O, Shah B, Naples M, Bednarek F, Zupancic J, Allred EN, Leviton A. Interinstitutional variation in prediction of death by SNAP-II and SNAPPE-II among extremely preterm infants. Pediatrics. 2009 Nov; 124(5):e1001-6.
    View in: PubMed
  24. Zupancic JA, Hibbs AM, Palermo L, Truog WE, Cnaan A, Black DM, Ballard PL, Wadlinger SR, Ballard RA. Economic evaluation of inhaled nitric oxide in preterm infants undergoing mechanical ventilation. Pediatrics. 2009 Nov; 124(5):1325-32.
    View in: PubMed
  25. Smith VC, Young S, Pursley DM, McCormick MC, Zupancic JA. Are families prepared for discharge from the NICU? J Perinatol. 2009 Sep; 29(9):623-9.
    View in: PubMed
  26. McBride JA, Parad RB, Davis JM, Zheng Z, Zupancic JA. Economic evaluation of recombinant human copper zinc superoxide dismutase administered at birth to premature infants. J Perinatol. 2009 May; 29(5):364-71.
    View in: PubMed
  27. Aslam M, Burris HH, Zupancic JA. Are we satisfied with the way we review an article? Adv Neonatal Care. 2009 Feb; 9(1):40-2.
    View in: PubMed
  28. Dennis CL, Hodnett E, Kenton L, Weston J, Zupancic J, Stewart DE, Kiss A. Effect of peer support on prevention of postnatal depression among high risk women: multisite randomised controlled trial. BMJ. 2009; 338:a3064.
    View in: PubMed
  29. Kamholz KL, Cole CH, Gray JE, Zupancic JA. Cost-effectiveness of early treatment for retinopathy of prematurity. Pediatrics. 2009 Jan; 123(1):262-9.
    View in: PubMed
  30. Zupancic JA. The economics of elective cesarean section. Clin Perinatol. 2008 Sep; 35(3):591-9, xii.
    View in: PubMed
  31. Williams C, Munson D, Zupancic J, Kirpalani H. Supporting bereaved parents: practical steps in providing compassionate perinatal and neonatal end-of-life care. A North American perspective. Semin Fetal Neonatal Med. 2008 Oct; 13(5):335-40.
    View in: PubMed
  32. Gray J, Geva A, Zheng Z, Zupancic JA. CoolSim: using industrial modeling techniques to examine the impact of selective head cooling in a model of perinatal regionalization. Pediatrics. 2008 Jan; 121(1):28-36.
    View in: PubMed
  33. Profit J, Zupancic JA, Gould JB, Petersen LA. Implementing pay-for-performance in the neonatal intensive care unit. Pediatrics. 2007 May; 119(5):975-82.
    View in: PubMed
  34. Profit J, McCormick MC, Escobar GJ, Richardson DK, Zheng Z, Coleman-Phox K, Roberts R, Zupancic JA. Neonatal intensive care unit census influences discharge of moderately preterm infants. Pediatrics. 2007 Feb; 119(2):314-9.
    View in: PubMed
  35. Vanpée M, Walfridsson-Schultz U, Katz-Salamon M, Zupancic JA, Pursley D, Jónsson B. Resuscitation and ventilation strategies for extremely preterm infants: a comparison study between two neonatal centers in Boston and Stockholm. Acta Paediatr. 2007 Jan; 96(1):10-6; discussion 8-9.
    View in: PubMed
  36. Zupancic JA, Richardson DK, Horbar JD, Carpenter JH, Lee SK, Escobar GJ. Revalidation of the Score for Neonatal Acute Physiology in the Vermont Oxford Network. Pediatrics. 2007 Jan; 119(1):e156-63.
    View in: PubMed
  37. Janssen PA, Still DK, Klein MC, Singer J, Carty EA, Liston RM, Zupancic JA. Early labor assessment and support at home versus telephone triage: a randomized controlled trial. Obstet Gynecol. 2006 Dec; 108(6):1463-9.
    View in: PubMed
  38. Escobar GJ, McCormick MC, Zupancic JA, Coleman-Phox K, Armstrong MA, Greene JD, Eichenwald EC, Richardson DK. Unstudied infants: outcomes of moderately premature infants in the neonatal intensive care unit. Arch Dis Child Fetal Neonatal Ed. 2006 Jul; 91(4):F238-44.
    View in: PubMed
  39. Zupancic JA, Richardson DK, O'Brien BJ, Cronin CG, Schmidt B, Roberts R, Weinstein MC. Retrospective economic evaluation of a controlled trial of indomethacin prophylaxis for patent ductus arteriosus in premature infants. Early Hum Dev. 2006 Feb; 82(2):97-103.
    View in: PubMed
  40. Profit J, Zupancic JA, McCormick MC, Richardson DK, Escobar GJ, Tucker J, Tarnow-Mordi W, Parry G. Moderately premature infants at Kaiser Permanente Medical Care Program in California are discharged home earlier than their peers in Massachusetts and the United Kingdom. Arch Dis Child Fetal Neonatal Ed. 2006 Jul; 91(4):F245-50.
    View in: PubMed
  41. Bastek TK, Richardson DK, Zupancic JA, Burns JP. Prenatal consultation practices at the border of viability: a regional survey. Pediatrics. 2005 Aug; 116(2):407-13.
    View in: PubMed
  42. Smith VC, Zupancic JA, McCormick MC, Croen LA, Greene J, Escobar GJ, Richardson DK. Trends in severe bronchopulmonary dysplasia rates between 1994 and 2002. J Pediatr. 2005 Apr; 146(4):469-73.
    View in: PubMed
  43. Escobar GJ, Shaheen SM, Breed EM, Botas C, Greene JD, Yoshida CK, Zupancic J, Newman TB. Richardson score predicts short-term adverse respiratory outcomes in newborns >/=34 weeks gestation. J Pediatr. 2004 Dec; 145(6):754-60.
    View in: PubMed
  44. Smith VC, Zupancic JA, McCormick MC, Croen LA, Greene J, Escobar GJ, Richardson DK. Rehospitalization in the first year of life among infants with bronchopulmonary dysplasia. J Pediatr. 2004 Jun; 144(6):799-803.
    View in: PubMed
  45. Dhillon AS, Albersheim SG, Alsaad S, Pargass NS, Zupancic JA. Internet use and perceptions of information reliability by parents in a neonatal intensive care unit. J Perinatol. 2003 Jul-Aug; 23(5):420-4.
    View in: PubMed
  46. Zupancic JA, Richardson DK, O'Brien BJ, Eichenwald EC, Weinstein MC. Cost-effectiveness analysis of predischarge monitoring for apnea of prematurity. Pediatrics. 2003 Jan; 111(1):146-52.
    View in: PubMed
  47. Zupancic JA, Richardson DK, O'Brien BJ, Schmidt B, Weinstein MC. Daily cost prediction model in neonatal intensive care. Int J Technol Assess Health Care. 2003; 19(2):330-8.
    View in: PubMed
  48. Zupancic JA, Richardson DK. Characterization of neonatal personnel time inputs and prediction from clinical variables--a time and motion study. J Perinatol. 2002 Dec; 22(8):658-63.
    View in: PubMed
  49. Zupancic JA, Kirpalani H, Barrett J, Stewart S, Gafni A, Streiner D, Beecroft ML, Smith P. Characterising doctor-parent communication in counselling for impending preterm delivery. Arch Dis Child Fetal Neonatal Ed. 2002 Sep; 87(2):F113-7.
    View in: PubMed
  50. Lee SK, Zupancic JA, Sale J, Pendray M, Whyte R, Brabyn D, Walker R, Whyte H. Cost-effectiveness and choice of infant transport systems. Med Care. 2002 Aug; 40(8):705-16.
    View in: PubMed
  51. Lee SK, Zupancic JA, Pendray M, Thiessen P, Schmidt B, Whyte R, Shorten D, Stewart S. Transport risk index of physiologic stability: a practical system for assessing infant transport care. J Pediatr. 2001 Aug; 139(2):220-6.
    View in: PubMed
  52. Richardson DK, Zupancic JA, Escobar GJ, Ogino M, Pursley DM, Mugford M. A critical review of cost reduction in neonatal intensive care. II. Strategies for reduction. J Perinatol. 2001 Mar; 21(2):121-7.
    View in: PubMed
  53. Richardson DK, Zupancic JA, Escobar GJ, Ogino M, Pursley DM, Mugford M. A critical review of cost reduction in neonatal intensive care. I. The structure of costs. J Perinatol. 2001 Mar; 21(2):107-15.
    View in: PubMed
  54. Zupancic JA, Richardson DK, Lee K, McCormick MC. Economics of prematurity in the era of managed care. Clin Perinatol. 2000 Jun; 27(2):483-97.
    View in: PubMed
  55. Zupancic JA, Triedman JK, Alexander M, Walsh EP, Richardson DK, Berul CI. Cost-effectiveness and implications of newborn screening for prolongation of QT interval for the prevention of sudden infant death syndrome. J Pediatr. 2000 Apr; 136(4):481-9.
    View in: PubMed
  56. Zupancic JA, Richardson DK. Characterization of the triage process in neonatal intensive care. Pediatrics. 1998 Dec; 102(6):1432-6.
    View in: PubMed
  57. Zupancic JA, Gillie P, Streiner DL, Watts JL, Schmidt B. Informed consent for randomised controlled trials in neonates. Arch Dis Child Fetal Neonatal Ed. 1998 Mar; 78(2):F156-7.
    View in: PubMed
  58. Zupancic JA, Gillie P, Streiner DL, Watts JL, Schmidt B. Determinants of parental authorization for involvement of newborn infants in clinical trials. Pediatrics. 1997 Jan; 99(1):E6.
    View in: PubMed
  59. Zupancic JA, Pennie RA, Issenman R. Intussusception in a child with cytomegalovirus infection. Pediatr Infect Dis J. 1994 Jun; 13(6):548-9.
    View in: PubMed
  60. Sherkin-Langer F, Langer JC, Zupancic J, Winthrop AL, Issenman RM. Home esophageal self-dilatation in children. Gastroenterol Nurs. 1993 Aug; 16(1):5-8.
    View in: PubMed
  61. Zupancic JA. Dangerous economics: resource allocation in the NICU. CMAJ. 1992 Mar 15; 146(6):1073-6.
    View in: PubMed
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