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Frank A.J.L. Scheer, PH.D.

TitleAssistant Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Womens Hospital
Division of Sleep Medicine
221 Longwood Ave
Boston MA 02115
Phone617/732-7014
Fax617/732-7337

 Biography 
 awards and honors
2005 - 2007Pickwick Postdoctoral Fellowship
2005 - Young Investigator Neurology Section Award
2006 - Alliance Chronosleep Award
2006 - Finalist Helgi Kristbjarnarson's Award
2007 - Young Investigator Award
2008 - 1st Place Clinical Research Young Investigator Award
2009 - Neal Miller Award
2010 - Young Investigator Award, Honorable Mention

 Overview 
 overview
Dr. Frank A.J.L. Scheer is Assistant Professor of Medicine at Harvard Medical School and the Director of the Medical Chronobiology Program at Brigham and Women’s Hospital.

Dr. Scheer is primarily interested in medical chronobiology, including the underlying physiological mechanisms and therapeutic strategies. His work focuses on circadian and behavioral influences (including the sleep/wake cycle) on cardiovascular, pulmonary, and metabolic regulation and disease. Furthermore, he is interested in fundamental properties of the human circadian timing system, including effects of light and melatonin.

Dr. Scheer received his PhD in Neuroscience at the Netherlands Institute for Brain Research in Amsterdam, The Netherlands, and his postdoctoral training in the laboratories of Drs. Charles A. Czeisler and Steven A. Shea.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hu K, Meijer JH, Shea SA, Vanderleest HT, Pittman-Polletta B, Houben T, van Oosterhout F, Deboer T, Scheer FA. Fractal Patterns of Neural Activity Exist within the Suprachiasmatic Nucleus and Require Extrinsic Network Interactions. PLoS One. 2012; 7(11):e48927.
    View in: PubMed
  2. Scheer FA, Morris CJ, Garcia JI, Smales C, Kelly EE, Marks J, Malhotra A, Shea SA. Repeated melatonin supplementation improves sleep in hypertensive patients treated with beta-blockers: a randomized controlled trial. Sleep. 2012; 35(10):1395-402.
    View in: PubMed
  3. Jeyaraj D, Scheer FA, Ripperger JA, Haldar SM, Lu Y, Prosdocimo DA, Eapen SJ, Eapen BL, Cui Y, Mahabeleshwar GH, Lee HG, Smith MA, Casadesus G, Mintz EM, Sun H, Wang Y, Ramsey KM, Bass J, Shea SA, Albrecht U, Jain MK. Klf15 orchestrates circadian nitrogen homeostasis. Cell Metab. 2012 Mar 7; 15(3):311-23.
    View in: PubMed
  4. Morris CJ, Yang JN, Scheer FA. The impact of the circadian timing system on cardiovascular and metabolic function. Prog Brain Res. 2012; 199:337-58.
    View in: PubMed
  5. Morris CJ, Aeschbach D, Scheer FA. Circadian system, sleep and endocrinology. Mol Cell Endocrinol. 2012 Feb 5; 349(1):91-104.
    View in: PubMed
  6. Scheer FA, Michelson AD, Frelinger AL, Evoniuk H, Kelly EE, McCarthy M, Doamekpor LA, Barnard MR, Shea SA. The human endogenous circadian system causes greatest platelet activation during the biological morning independent of behaviors. PLoS One. 2011; 6(9):e24549.
    View in: PubMed
  7. Shea SA, Hilton MF, Hu K, Scheer FA. Existence of an endogenous circadian blood pressure rhythm in humans that peaks in the evening. Circ Res. 2011 Apr 15; 108(8):980-4.
    View in: PubMed
  8. Kalsbeek A, Scheer FA, Perreau-Lenz S, La Fleur SE, Yi CX, Fliers E, Buijs RM. Circadian disruption and SCN control of energy metabolism. FEBS Lett. 2011 May 20; 585(10):1412-26.
    View in: PubMed
  9. Hu K, Scheer FA, Laker M, Smales C, Shea SA. Endogenous circadian rhythm in vasovagal response to head-up tilt. Circulation. 2011 Mar 8; 123(9):961-70.
    View in: PubMed
  10. Chang AM, Scheer FA, Czeisler CA. The human circadian system adapts to prior photic history. J Physiol. 2011 Mar 1; 589(Pt 5):1095-102.
    View in: PubMed
  11. Scheer FA, Hu K, Evoniuk H, Kelly EE, Malhotra A, Hilton MF, Shea SA. Impact of the human circadian system, exercise, and their interaction on cardiovascular function. Proc Natl Acad Sci U S A. 2010 Nov 23; 107(47):20541-6.
    View in: PubMed
  12. Scheer FA, Chan JL, Fargnoli J, Chamberland J, Arampatzi K, Shea SA, Blackburn GL, Mantzoros CS. Day/night variations of high-molecular-weight adiponectin and lipocalin-2 in healthy men studied under fed and fasted conditions. Diabetologia. 2010 Nov; 53(11):2401-5.
    View in: PubMed
  13. Jung CM, Khalsa SB, Scheer FA, Cajochen C, Lockley SW, Czeisler CA, Wright KP. Acute effects of bright light exposure on cortisol levels. J Biol Rhythms. 2010 Jun; 25(3):208-16.
    View in: PubMed
  14. Rüger M, Scheer FA. Effects of circadian disruption on the cardiometabolic system. Rev Endocr Metab Disord. 2009 Dec; 10(4):245-60.
    View in: PubMed
  15. Pavlova MK, Shea SA, Scheer FA, Bromfield EB. Is there a circadian variation of epileptiform abnormalities in idiopathic generalized epilepsy? Epilepsy Behav. 2009 Nov; 16(3):461-7.
    View in: PubMed
  16. Litinski M, Scheer FA, Shea SA. Influence of the Circadian System on Disease Severity. Sleep Med Clin. 2009 Jun 1; 4(2):143-163.
    View in: PubMed
  17. Scheer FA, Hilton MF, Mantzoros CS, Shea SA. Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4453-8.
    View in: PubMed
  18. Hu K, Van Someren EJ, Shea SA, Scheer FA. Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: Involvement of the circadian pacemaker. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2490-4.
    View in: PubMed
  19. Scheer FA, Shea TJ, Hilton MF, Shea SA. An endogenous circadian rhythm in sleep inertia results in greatest cognitive impairment upon awakening during the biological night. J Biol Rhythms. 2008 Aug; 23(4):353-61.
    View in: PubMed
  20. Hu K, Scheer FA, Buijs RM, Shea SA. The circadian pacemaker generates similar circadian rhythms in the fractal structure of heart rate in humans and rats. Cardiovasc Res. 2008 Oct 1; 80(1):62-8.
    View in: PubMed
  21. Hu K, Scheer FA, Buijs RM, Shea SA. The endogenous circadian pacemaker imparts a scale-invariant pattern of heart rate fluctuations across time scales spanning minutes to 24 hours. J Biol Rhythms. 2008 Jun; 23(3):265-73.
    View in: PubMed
  22. Hu K, Scheer FA, Ivanov PCh, Buijs RM, Shea SA. The suprachiasmatic nucleus functions beyond circadian rhythm generation. Neuroscience. 2007 Nov 9; 149(3):508-17.
    View in: PubMed
  23. Scheer FA, Wright KP, Kronauer RE, Czeisler CA. Plasticity of the intrinsic period of the human circadian timing system. PLoS One. 2007; 2(8):e721.
    View in: PubMed
  24. Scheer FA, Stone PH, Shea SA. Decreased sleep in heart failure: are medications to blame? Arch Intern Med. 2007 May 28; 167(10):1098-9; author reply 1099-100.
    View in: PubMed
  25. Shea SA, Hu K, Buijs RM, Scheer FAJL. Lesioning the suprachiasmatic nucleus abolishes ultradian rhythms of locomotor activity in rats. Sleep. 2007; 30:A58.
  26. Scheer FAJL, Hilton MF, Benjamin T, Barb D, Evoniuk H, Mantzoros CS, Shea SA. . Desynchrony between sleep-wake cycle and circadian cycle leads to suppressed plasma leptin; potential relevance for shift workers. Sleep. 2007; 30:A61.
  27. Hu K, Scheer FAJL, Buijs RM, Shea SA. The circadian pacemaker contributes to intrinsic scale-invariant patterns of cardiac dynamics across a wide range of time scales – Spanning 4-24 Hours. Sleep. 2007; 30:A58.
  28. Hu K, Scheer FAJL, Buijs RM, Shea SA. Effect of lesioning the suprachiasmatic nucleus on fractal pattern of heart rate fluctuations. Sleep. 2007; 30:A64.
  29. Shea SA, Scheer FAJL, Hilton MF. Predicting the daily pattern of asthma severity based on the relative contribution of the circadian timing system, the sleep-wake cycle and the environment. Sleep. 2007; 30:A65.
  30. Scheer FAJL, Hahn M, Doamekpor LA, Evoniuk H, Kelly K, Laker MD, Shea SA. Lack of endogenous circadian rhythm of platelet aggregability. Sleep. 2007; 30:A64.
  31. Kalsbeek A, Palm IF, La Fleur SE, Scheer FA, Perreau-Lenz S, Ruiter M, Kreier F, Cailotto C, Buijs RM. SCN outputs and the hypothalamic balance of life. J Biol Rhythms. 2006 Dec; 21(6):458-69.
    View in: PubMed
  32. Lockley SW, Evans EE, Scheer FA, Brainard GC, Czeisler CA, Aeschbach D. Short-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans. Sleep. 2006 Feb; 29(2):161-8.
    View in: PubMed
  33. Scheer FA, Zeitzer JM, Ayas NT, Brown R, Czeisler CA, Shea SA. Reduced sleep efficiency in cervical spinal cord injury; association with abolished night time melatonin secretion. Spinal Cord. 2006 Feb; 44(2):78-81.
    View in: PubMed
  34. Frank A.J.L. Scheer, Thomas J. Shea, Heather L. Evoniuk, Michael F. Hilton. Circadian Rhythm in Degree of Sleep Inertia Following Awakening. J Sleep Res. 2006; 15(1):55.
  35. Buijs RM, Scheer FA, Kreier F, Yi C, Bos N, Goncharuk VD, Kalsbeek A. Organization of circadian functions: interaction with the body. Prog Brain Res. 2006; 153:341-60.
    View in: PubMed
  36. Shea TJ, Hilton MF, Evoniuk H, Scheer FAJL. Circadian effect on degree of sleep inertia present after awakening. Sleep. 2006; A67.
  37. Evoniuk HL, Scheer FAJL, Hilton MF, Schory KE, Shea SA. Challenges to sleep in asthma studied under baseline conditions, reduced homeostatic sleep drive, and adverse circadian phase for sleep. Sleep. 2006.
  38. Frank A.J.L. Scheer. Suprachiasmatic nucleus, environmental light, and metabolic state interact in the regulation of body temperature. J Sleep Res. 2006; 15(1):20.
  39. Scheer FAJL. Suprachiasmatic nucleus, environmental light, and metabolic state interact in the regulation of body temperature. J Sleep Res. 2006; 20.
  40. Thomas J Shea, Michael F Hilton, Heather L Evoniuk, Frank AJL Scheer. Circadian Effect on Degree of Sleep Inertia Present After Awakening. Sleep. 2006; 29:A67.
  41. Kun Hu, Frank A.J.L. Scheer, Plamen Ch. Ivanov, Ruud M. Buijs, Steven A. Shea. Intrinsic scale-invariant patterns of locomotor activity: role of the circadian pacemaker across a wide range of time scales – spanning 4-24 hours. Sleep. 2006; 29:A64.
  42. Scheer FA. Potential use of melatonin as adjunct antihypertensive therapy. Am J Hypertens. 2005 Dec; 18(12 Pt 1):1619-20.
    View in: PubMed
  43. Scheer FA, Czeisler CA. Melatonin, sleep, and circadian rhythms. Sleep Med Rev. 2005 Feb; 9(1):5-9.
    View in: PubMed
  44. Shea SA, Scheer FAJL, Evoniuk HL, Shiels SA, Malhotra A, Sugarbaker R, Ayers RT, Okruch A, Weiner M, Rinzler S, Massaro AF, Hilton MF. Role of the endogenous circadian system in bronchoconstriction, airway inflammation and rescue medication use in asthma. Chronobiology Int. 2005.
  45. Scheer FAJL, Cajochen C, Turek FW, Czeisler CA. . Melatonin in the regulation of sleep and circadian rhythms. Kryger MH, Roth T, Dement WC (ed). Principles and Practice of Sleep Medicine. 2005; 395-404.
  46. Scheer FAJL, Wright Jr. KP, Gronfier C, Kronauer RE, Czeisler CA. Human circadian period is influenced by entrainment to non-24 hour schedules. Sleep. 2005; 28:A72.
  47. Scheer FA, Pirovano C, Van Someren EJ, Buijs RM. Environmental light and suprachiasmatic nucleus interact in the regulation of body temperature. Neuroscience. 2005; 132(2):465-77.
    View in: PubMed
  48. Shea SA, Hilton MF, Malhotra A, Evoniuk H, Shiels S, Sugarbaker R, Ayers RT, Weiner M, Massaro AF, Scheer FAJL. . Interaction between effects of the circadian pacemaker and behavioral sleep-wake cycle on pulmonary function in asthma. Sleep. 2005; 28:A73.
  49. Jung CM, Khalsa S, Scheer FA, Czeisler CA, Wright KP. Acute effects of bright light exposure on nighttime cortisol levels in humans. Sleep. 2005; 28:A59.
  50. Evoniuk H, Hilton MF, Scheer FAJL, Malhotra A, Shiels S, Sugarbaker R, Weiner M, Ayers RT, Massaro AF, Shea SA. Effects of endogenous circadian rhythms, sleep and sleep deprivation on airway function in asthma explored with a constant routine protocol. Sleep. 2005; 28:A71.
  51. Scheer FA, Van Doornen LJ, Buijs RM. Light and diurnal cycle affect autonomic cardiac balance in human; possible role for the biological clock. Auton Neurosci. 2004 Jan 30; 110(1):44-8.
    View in: PubMed
  52. Scheer FA, Van Montfrans GA, van Someren EJ, Mairuhu G, Buijs RM. Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension. Hypertension. 2004 Feb; 43(2):192-7.
    View in: PubMed
  53. Scheer FAJL, Van Montfrans GA, Buijs RM. . Chronic, but not acute, nighttime melatonin administration improves sleep quality in hypertensive patients. Sleep. 2004; 27:A329.
  54. Shea SA, Hilton MF, Scheer FA, Ayers R, Evoniuk HL, Shiels SA, Sugarbaker RJ, Malhotra A, Massaro AF. An endogenous circadian rhythm in bronchodilator rescue medication use in asthma. Sleep. 2004; 27:A81.
  55. Scheer FA, Kalsbeek A, Buijs RM. Cardiovascular control by the suprachiasmatic nucleus: neural and neuroendocrine mechanisms in human and rat. Biol Chem. 2003 May; 384(5):697-709.
    View in: PubMed
  56. Scheer FA, Van Paassen B, Van Montfrans GA, Fliers E, Van Someren EJ, Van Heerikhuize JJ, Buijs RM. Human basal cortisol levels are increased in hospital compared to home setting. Neurosci Lett. 2002 Nov 22; 333(2):79-82.
    View in: PubMed
  57. Scheer FA, Ter Horst GJ, van Der Vliet J, Buijs RM. Physiological and anatomic evidence for regulation of the heart by suprachiasmatic nucleus in rats. Am J Physiol Heart Circ Physiol. 2001 Mar; 280(3):H1391-9.
    View in: PubMed
  58. Buijs RM, Hermes MLHJ, Dai J, Scheer FAJL, Kalsbeek A. Circadian organization of the autonomic Nervous system. Ter Horst GJ (ed). The Nervous System and the Heart. 2000; 117-157.
  59. Scheer FA, Buijs RM. Light affects morning salivary cortisol in humans. J Clin Endocrinol Metab. 1999 Sep; 84(9):3395-8.
    View in: PubMed
  60. Scheer FA, van Doornen LJ, Buijs RM. Light and diurnal cycle affect human heart rate: possible role for the circadian pacemaker. J Biol Rhythms. 1999 Jun; 14(3):202-12.
    View in: PubMed
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