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Robert Hugh Demling, M.D.

TitleProfessor of Surgery
InstitutionBrigham and Women's Hospital
DepartmentSurgery
AddressBrigham and Women's Hospital
Surgery
75 Francis St
Boston MA 02115
Phone617/732-7715
Fax617/566-9549

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Demling RH. Nutrition, anabolism, and the wound healing process: an overview. Eplasty. 2009; 9:e9.
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  2. Demling RH. Burns: what are the pharmacological treatment options? Expert Opin Pharmacother. 2008 Aug; 9(11):1895-908.
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  3. Demling RH. Smoke inhalation lung injury: an update. Eplasty. 2008; 8:e27.
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  4. Demling RH, Waterhouse B. The increasing problem of wound bacterial burden and infection in acute and chronic soft-tissue wounds caused by methicillin-resistant Staphylococcus aureus. J Burns Wounds. 2007; 7:e8.
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  5. Demling R. The use of anabolic agents in catabolic states. J Burns Wounds. 2007; 6:e2.
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  6. Pomahac B, Matros E, Semel M, Chan RK, Rogers SO, Demling R, Orgill DP. Predictors of survival and length of stay in burn patients older than 80 years of age: does age really matter? J Burn Care Res. 2006 May-Jun; 27(3):265-9.
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  7. Parrett BM, Pomahac B, Demling RH, Orgill DP. Fourth-degree burns to the lower extremity with exposed tendon and bone: a ten-year experience. J Burn Care Res. 2006 Jan-Feb; 27(1):34-9.
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  8. Demling RH. The burn edema process: current concepts. J Burn Care Rehabil. 2005 May-Jun; 26(3):207-27.
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  9. Demling RH. The role of anabolic hormones for wound healing in catabolic states. J Burns Wounds. 2005; 4:e2.
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  10. Demling RH. The incidence and impact of pre-existing protein energy malnutrition on outcome in the elderly burn patient population. J Burn Care Rehabil. 2005 Jan-Feb; 26(1):94-100.
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  11. Demling RH. The clinical relevance of defining the mechanism for altered gut permeability in a "two-hit" model of injury and infection. Crit Care Med. 2004 Nov; 32(11):2356-7.
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  12. Theopold C, Hoeller D, Velander P, Demling R, Eriksson E. Graft site malignancy following treatment of full-thickness burn with cultured epidermal autograft. Plast Reconstr Surg. 2004 Oct; 114(5):1215-9.
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  13. Demling RH, DeSanti L. Oxandrolone induced lean mass gain during recovery from severe burns is maintained after discontinuation of the anabolic steroid. Burns. 2003 Dec; 29(8):793-7.
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  14. Orgill DP, Neuwalder JM, Arch M, Orgill J, Demling R. The development of an educational web site for burn care: burnsurgery.org. J Burn Care Rehabil. 2002 May-Jun; 23(3):216-9.
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  15. Demling RH, Leslie DeSanti MD. The rate of re-epithelialization across meshed skin grafts is increased with exposure to silver. Burns. 2002 May; 28(3):264-6.
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  16. Demling RH, DeSanti L. Scar management strategies in wound care. Rehab Manag. 2001 Aug-Sep; 14(6):26-30.
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  17. Demling RH. Involuntary weight loss, wound healing, and optimal nutritional intervention. J Am Med Dir Assoc. 2001 Jul-Aug; 2(4):H2-4.
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  18. Demling RH, DeSanti L. The rate of restoration of body weight after burn injury, using the anabolic agent oxandrolone, is not age dependent. Burns. 2001 Feb; 27(1):46-51.
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  19. Demling RH, Seigne P. Metabolic management of patients with severe burns. World J Surg. 2000 Jun; 24(6):673-80.
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  20. Bernard GR, Sopko G, Cerra F, Demling R, Edmunds H, Kaplan S, Kessler L, Masur H, Parsons P, Shure D, Webb C, Weidemann H, Weinmann G, Williams D. Pulmonary artery catheterization and clinical outcomes: National Heart, Lung, and Blood Institute and Food and Drug Administration Workshop Report. Consensus Statement. JAMA. 2000 May 17; 283(19):2568-72.
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  21. Demling RH. Enteral glutamine administration prevents the decrease in cell energy charge potential produced in ileum after a skin burn in the rat. J Burn Care Rehabil. 2000 May-Jun; 21(3):275-9; discussion 274.
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  22. Demling RH. Oxandrolone, an anabolic steroid, enhances the healing of a cutaneous wound in the rat. Wound Repair Regen. 2000 Mar-Apr; 8(2):97-102.
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  23. Demling RH, Orgill DP. The anticatabolic and wound healing effects of the testosterone analog oxandrolone after severe burn injury. J Crit Care. 2000 Mar; 15(1):12-7.
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  24. Demling RH, DeSanti L. Effect of a hypocaloric diet, increased protein intake and resistance training on lean mass gains and fat mass loss in overweight police officers. Ann Nutr Metab. 2000; 44(1):21-9.
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  25. Demling R. Growth hormone therapy in critically ill patients. N Engl J Med. 1999 Sep 9; 341(11):837-9.
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  26. Demling RH, DeSanti L. Management of partial thickness facial burns (comparison of topical antibiotics and bio-engineered skin substitutes). Burns. 1999 May; 25(3):256-61.
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  27. Demling RH. Comparison of the anabolic effects and complications of human growth hormone and the testosterone analog, oxandrolone, after severe burn injury. Burns. 1999 May; 25(3):215-21.
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  28. Demling RH, DeSanti L. Involuntary weight loss and the nonhealing wound: the role of anabolic agents. Adv Wound Care. 1999 Jan-Feb; 12(1 Suppl):1-14; quiz 15-6.
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  29. Youn YK, Suh GJ, Jung SE, Oh SK, Demling R. Recombinant human growth hormone decreases lung and liver tissue lipid peroxidation and increases antioxidant activity after thermal injury in rats. J Burn Care Rehabil. 1998 Nov-Dec; 19(6):542-8.
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  30. Demling R, De Santi L. Closure of the "non-healing wound" corresponds with correction of weight loss using the anabolic agent oxandrolone. Ostomy Wound Manage. 1998 Oct; 44(10):58-62, 64, 66 passim.
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  31. Chang DW, DeSanti L, Demling RH. Anticatabolic and anabolic strategies in critical illness: a review of current treatment modalities. Shock. 1998 Sep; 10(3):155-60.
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  32. DeSanti L, Lincoln L, Egan F, Demling R. Development of a burn rehabilitation unit: impact on burn center length of stay and functional outcome. J Burn Care Rehabil. 1998 Sep-Oct; 19(5):414-9.
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  33. Demling RH, DeSanti L. Increased protein intake during the recovery phase after severe burns increases body weight gain and muscle function. J Burn Care Rehabil. 1998 Mar-Apr; 19(2):161-8; discussion 160.
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  34. LaLonde C, Hennigan J, Nayak U, Demling R. Energy charge potential and glutathione levels as predictors of outcome following burn injury complicated by endotoxemia. Shock. 1998 Jan; 9(1):27-32.
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  35. LaLonde C, Nayak U, Hennigan J, Demling R. Plasma catalase and glutathione levels are decreased in response to inhalation injury. J Burn Care Rehabil. 1997 Nov-Dec; 18(6):515-9.
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  36. Demling RH, DeSanti L. Oxandrolone, an anabolic steroid, significantly increases the rate of weight gain in the recovery phase after major burns. J Trauma. 1997 Jul; 43(1):47-51.
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  37. Bae RJ, Orgill DP, DeBiasse MA, Demling R. Management of a patient with advanced AIDS and toxic epidermal necrolysis using human growth hormone and G-CSF. AIDS Patient Care STDS. 1997 Jun; 11(3):125-9.
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  38. LaLonde C, Nayak U, Hennigan J, Demling RH. Excessive liver oxidant stress causes mortality in response to burn injury combined with endotoxin and is prevented with antioxidants. J Burn Care Rehabil. 1997 May-Jun; 18(3):187-92.
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  39. LaLonde C, Nayak U, Hennigan J, Demling R. Antioxidants prevent the cellular deficit produced in response to burn injury. J Burn Care Rehabil. 1996 Sep-Oct; 17(5):379-83.
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  40. Knox JB, Wilmore DW, Demling RH, Sarraf P, Santos AA. Use of growth hormone for postoperative respiratory failure. Am J Surg. 1996 Jun; 171(6):576-80.
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  41. Gamliel Z, DeBiasse MA, Demling RH. Essential microminerals and their response to burn injury. J Burn Care Rehabil. 1996 May-Jun; 17(3):264-72.
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  42. Demling R, LaLonde C, Ikegami K. Fluid resuscitation with deferoxamine hetastarch complex attenuates the lung and systemic response to smoke inhalation. Surgery. 1996 Mar; 119(3):340-8.
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  43. Demling RH. The advantage of the burn team approach. J Burn Care Rehabil. 1995 Nov-Dec; 16(6):569-72.
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  44. Upchurch GR, Demling RH, Davies J, Gates JD, Knox JB. Efficacy of subcutaneous heparin in prevention of venous thromboembolic events in trauma patients. Am Surg. 1995 Sep; 61(9):749-55.
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  45. Knox J, Demling R, Wilmore D, Sarraf P, Santos A. Increased survival after major thermal injury: the effect of growth hormone therapy in adults. J Trauma. 1995 Sep; 39(3):526-30; discussion 530-2.
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  46. Demling RH, DeBiasse MA. Micronutrients in critical illness. Crit Care Clin. 1995 Jul; 11(3):651-73.
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  47. Demling RH. Use of Biobrane in management of scalds. J Burn Care Rehabil. 1995 May-Jun; 16(3 Pt 1):329-30.
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  48. Knox JB, Demling RH, Wilmore DW, Sarraf P, Santos AA. Hypercalcemia associated with the use of human growth hormone in an adult surgical intensive care unit. Arch Surg. 1995 Apr; 130(4):442-5.
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  49. Demling R, Ikegami K, Lalonde C. Increased lipid peroxidation and decreased antioxidant activity correspond with death after smoke exposure in the rat. J Burn Care Rehabil. 1995 Mar-Apr; 16(2 Pt 1):104-10.
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  50. Demling R, LaLonde C, Ikegami K, Picard L, Nayak U. Alpha-tocopherol attenuates lung edema and lipid peroxidation caused by acute zymosan-induced peritonitis. Surgery. 1995 Feb; 117(2):226-31.
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  51. Lalonde C, Picard L, Youn YK, Demling RH. Increased early postburn fluid requirements and oxygen demands are predictive of the degree of airways injury by smoke inhalation. J Trauma. 1995 Feb; 38(2):175-84.
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  52. Demling R, Lalonde C, Youn YK, Picard L. Effect of graded increases in smoke inhalation injury on the early systemic response to a body burn. Crit Care Med. 1995 Jan; 23(1):171-8.
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  53. Demling RH. The modern version of adult respiratory distress syndrome. Annu Rev Med. 1995; 46:193-202.
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  54. LaLonde C, Ikegami K, Demling R. Aerosolized deferoxamine prevents lung and systemic injury caused by smoke inhalation. J Appl Physiol. 1994 Nov; 77(5):2057-64.
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  55. Demling R, Ikegami K, Picard L, Lalonde C. Administration of large doses of vitamin C does not decrease oxidant-induced lung lipid peroxidation caused by bacterial-independent acute peritonitis. Inflammation. 1994 Oct; 18(5):499-510.
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  56. Demling R, Nayak U, Ikegami K, LaLonde C. Comparison between lung and liver lipid peroxidation and mortality after zymosan peritonitis in the rat. Shock. 1994 Sep; 2(3):222-7.
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  57. Lalonde C, Demling R, Brain J, Blanchard J. Smoke inhalation injury in sheep is caused by the particle phase, not the gas phase. J Appl Physiol. 1994 Jul; 77(1):15-22.
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  58. Demling RH, Lalonde C, Ikegami K. Physiologic support of the septic patient. Surg Clin North Am. 1994 Jun; 74(3):637-58.
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  59. Demling R, LaLonde C, Heron P. Initial effect of smoke inhalation injury on oxygen consumption (response to positive pressure ventilation). Surgery. 1994 May; 115(5):563-70.
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  60. Ikegami K, Lalonde C, Young YK, Picard L, Demling R. Comparison of plasma reduced glutathione and oxidized glutathione with lung and liver tissue oxidant and antioxidant activity during acute inflammation. Shock. 1994 Apr; 1(4):307-12.
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  61. Demling R, Lalonde C, Picard L, Blanchard J. Changes in lung and systemic oxidant and antioxidant activity after smoke inhalation. Shock. 1994 Feb; 1(2):101-7.
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  62. Demling R, Lalonde C, Heron P, Picard L, Blanchard J, Brain J. Effect of increasing the tidal volume of smoke breaths on smoke-induced lung dysfunction. J Appl Physiol. 1994 Jan; 76(1):283-90.
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  63. Lalonde C, Picard L, Campbell C, Demling R. Lung and systemic oxidant and antioxidant activity after graded smoke exposure in the rat. Circ Shock. 1994 Jan; 42(1):7-13.
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  64. Demling R, Picard L, Campbell C, Lalonde C. Relationship of burn-induced lung lipid peroxidation on the degree of injury after smoke inhalation and a body burn. Crit Care Med. 1993 Dec; 21(12):1935-43.
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  65. Demling R, Daryani R, Campbell C, Knox J, Youn YK, Lalonde C. The effect of acute nonbacterial dependent peritonitis on lung and liver oxidant stress and antioxidant activity. Surgery. 1993 Sep; 114(3):571-8.
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  66. Demling RH. Adult respiratory distress syndrome: current concepts. New Horiz. 1993 Aug; 1(3):388-401.
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  67. Demling RH, Pomfret EA. Blunt chest trauma. New Horiz. 1993 Aug; 1(3):402-21.
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  68. Demling RH, Riessen R. Respiratory failure after cerebral injury. New Horiz. 1993 Aug; 1(3):440-6.
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  69. Britto J, Demling RH. Aspiration lung injury. New Horiz. 1993 Aug; 1(3):435-9.
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  70. Demling RH, Knox JB. Basic concepts of lung function and dysfunction: oxygenation, ventilation, and mechanics. New Horiz. 1993 Aug; 1(3):362-70.
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  71. Demling RH. Smoke inhalation injury. New Horiz. 1993 Aug; 1(3):422-34.
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  72. Demling RH, LaLonde C, Ikegami K. Pulmonary edema: pathophysiology, methods of measurement, and clinical importance in acute respiratory failure. New Horiz. 1993 Aug; 1(3):371-80.
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  73. Demling RH, Chen C. Pulmonary function in the burn patient. Semin Nephrol. 1993 Jul; 13(4):371-81.
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  74. LaLonde C, Daryani R, Campbell C, Knox J, Youn YK, Demling R. Relationship between liver oxidant stress and antioxidant activity after zymosan peritonitis in the rat. Crit Care Med. 1993 Jun; 21(6):894-900.
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  75. Demling R, LaLonde C, Saldinger P, Knox J. Multiple-organ dysfunction in the surgical patient: pathophysiology, prevention, and treatment. Curr Probl Surg. 1993 Apr; 30(4):345-414.
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  76. Youn YK, Knox J, Lalonde C, Demling R. Pentoxifylline does not prevent endotoxin induced lung and liver lipid peroxidation in the adult sheep. Circ Shock. 1993 Jan; 39(1):39-43.
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  77. Demling RH. Early increased gut permeability after burns. Crit Care Med. 1992 Nov; 20(11):1503.
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  78. Lalonde C, Knox J, Youn YK, Demling R. Burn edema is accentuated by a moderate smoke inhalation injury in sheep. Surgery. 1992 Nov; 112(5):908-17.
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  79. Demling R, Lalonde C, Youn YK, Daryani R, Campbell C, Knox J. Lung oxidant changes after zymosan peritonitis: relationship between physiologic and biochemical changes. Am Rev Respir Dis. 1992 Nov; 146(5 Pt 1):1272-8.
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  80. Lalonde C, Knox J, Youn YK, Demling R. Relationship between hepatic blood flow and tissue lipid peroxidation in the early postburn period. Crit Care Med. 1992 Jun; 20(6):789-96.
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  81. Demling RH, Knox J, Youn YK, LaLonde C. Oxygen consumption early postburn becomes oxygen delivery dependent with the addition of smoke inhalation injury. J Trauma. 1992 May; 32(5):593-8; discussion 599.
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  82. Davis JM, Demling RH, Lewis FR, Hoover E, Waymack JP. The Surgical Infection Society's policy on human immunodeficiency virus and hepatitis B and C infection. The Ad Hoc Committee on Acquired Immunodeficiency Syndrome and Hepatitis. Arch Surg. 1992 Feb; 127(2):218-21.
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  83. Youn YK, Lalonde C, Demling R. Oxidants and the pathophysiology of burn and smoke inhalation injury. Free Radic Biol Med. 1992; 12(5):409-15.
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  84. Youn YK, LaLonde C, Demling R. The role of mediators in the response to thermal injury. World J Surg. 1992 Jan-Feb; 16(1):30-6.
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  85. Demling RH, Knox J, Youn YK, Daryani R, LaLonde C. Effect of dobutamine infusion on endotoxin-induced lipid peroxidation in awake sheep. Surgery. 1992 Jan; 111(1):79-85.
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  86. Youn YK, LaLonde C, Demling R. Use of antioxidant therapy in shock and trauma. Circ Shock. 1991 Dec; 35(4):245-9.
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  87. Chernow B, Cerra FB, Demling RH. Critical care publishing: rules of the game. Crit Care Med. 1991 Sep; 19(9):1101-2.
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  88. Demling RH, La Londe C, Daryani R, Zhu DG, Knox J, Youn YK. Relationship between the lung and systemic response to endotoxin: comparison of physiologic change and the degree of lipid peroxidation. Circ Shock. 1991 Aug; 34(4):364-70.
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  89. Demling RH, Frye E, Read T. Effect of sequential early burn wound excision and closure on postburn oxygen consumption. Crit Care Med. 1991 Jul; 19(7):861-6.
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  90. LaLonde C, Knox J, Daryani R, Zhu DG, Demling RH, Neumann M. Topical flurbiprofen decreases burn wound-induced hypermetabolism and systemic lipid peroxidation. Surgery. 1991 May; 109(5):645-51.
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  91. Knox J, Youn YK, Lalonde C, Demling R. Effect of dobutamine on oxygen consumption and fluid and protein losses after endotoxemia. Crit Care Med. 1991 Apr; 19(4):525-31.
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  92. Demling R, LaLonde C, Knox J, Youn YK, Zhu D, Daryani R. Fluid resuscitation with deferoxamine prevents systemic burn-induced oxidant injury. J Trauma. 1991 Apr; 31(4):538-43; discussion 543-4.
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  93. Daryani R, LaLonde C, Zhu D, Demling RH. Changes in catalase activity in lung and liver after endotoxemia in sheep. Circ Shock. 1990 Dec; 32(4):273-80.
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  94. Demling RH, LaLonde C. Identification and modifications of the pulmonary and systemic inflammatory and biochemical changes caused by a skin burn. J Trauma. 1990 Dec; 30(12 Suppl):S57-62.
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  95. Daryani R, LaLonde C, Zhu D, Weidner M, Knox J, Demling RH. Effect of endotoxin and a burn injury on lung and liver lipid peroxidation and catalase activity. J Trauma. 1990 Nov; 30(11):1330-4.
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  96. Ziegler TR, Young LS, Ferrari-Baliviera E, Demling RH, Wilmore DW. Use of human growth hormone combined with nutritional support in a critical care unit. JPEN J Parenter Enteral Nutr. 1990 Nov-Dec; 14(6):574-81.
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  97. Demling RH, LaLonde C. Moderate smoke inhalation produces decreased oxygen delivery, increased oxygen demands, and systemic but not lung parenchymal lipid peroxidation. Surgery. 1990 Sep; 108(3):544-52.
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  98. Meumann M, Demling RH. Colloid vs crystalloid: a current perspective. Confed Aust Crit Care Nurses J. 1990 Sep; 3(3):30-5.
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  99. Demling RH, LaLonde C. Early burn excision attenuates the postburn lung and systemic response to endotoxin. Surgery. 1990 Jul; 108(1):28-35.
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  100. Demling R, Riessen R. Pulmonary dysfunction after cerebral injury. Crit Care Med. 1990 Jul; 18(7):768-74.
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  101. Demling RH, LaLonde C. Effect of a body burn on endotoxin-induced lipid peroxidation: comparison with physiologic and histologic changes. Surgery. 1990 Jun; 107(6):669-76.
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  102. Demling RH. Current concepts on the adult respiratory distress syndrome. Circ Shock. 1990 Apr; 30(4):297-309.
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  103. Demling RH, LaLonde C. Early postburn lipid peroxidation: effect of ibuprofen and allopurinol. Surgery. 1990 Jan; 107(1):85-93.
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  104. Demling R, Heimbach D. The burn surgeon and the need for critical care certification. J Burn Care Rehabil. 1990 Jan-Feb; 11(1):91-2.
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  105. Demling RH, Lalonde C. Systemic lipid peroxidation and inflammation induced by thermal injury persists into the post-resuscitation period. J Trauma. 1990 Jan; 30(1):69-74.
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  106. Demling RH, Lalonde C, Fogt F, Zhu DG, Liu YP. Effect of increasing oxygen delivery postburn on oxygen consumption and oxidant-induced lipid peroxidation in the adult sheep. Crit Care Med. 1989 Oct; 17(10):1025-30.
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  107. Demling RH, Lalonde C. Oxygen consumption is increased in the postanesthesia period after burn excision. J Burn Care Rehabil. 1989 Sep-Oct; 10(5):381-7.
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  108. Demling RH. Assessing the critical care needs of the surgical patient. Bull Am Coll Surg. 1989 Aug; 74(8):13-4.
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  109. Demling RH, LaLonde C, Liu YP, Zhu DG. The lung inflammatory response to thermal injury: relationship between physiologic and histologic changes. Surgery. 1989 Jul; 106(1):52-9.
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  110. Demling R, LaLonde C. Relationship between lung injury and lung lipid peroxidation caused by recurrent endotoxemia. Am Rev Respir Dis. 1989 May; 139(5):1118-24.
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  111. LaLonde C, Demling RH. Inhibition of thromboxane synthetase accentuates hemodynamic instability and burn edema in the anesthetized sheep model. Surgery. 1989 May; 105(5):638-44.
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  112. Demling RH, LaLonde C, Goad ME. Effect of ibuprofen on the pulmonary and systemic response to repeated doses of endotoxin. Surgery. 1989 Mar; 105(3):421-9.
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  113. Ziegler TR, Smith RJ, O'Dwyer ST, Demling RH, Wilmore DW. Increased intestinal permeability associated with infection in burn patients. Arch Surg. 1988 Nov; 123(11):1313-9.
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  114. Demling RH, Lalonde C. Effect of partial burn excision and closure on postburn oxygen consumption. Surgery. 1988 Nov; 104(5):846-52.
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  115. Demling R, Lalonde C, Seekamp A, Fiore N. Endotoxin causes hydrogen peroxide-induced lung lipid peroxidation and prostanoid production. Arch Surg. 1988 Nov; 123(11):1337-41.
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  116. Orgill D, Demling RH. Current concepts and approaches to wound healing. Crit Care Med. 1988 Sep; 16(9):899-908.
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  117. Seekamp A, Lalonde C, Zhu DG, Demling R. Catalase prevents prostanoid release and lung lipid peroxidation after endotoxemia in sheep. J Appl Physiol. 1988 Sep; 65(3):1210-6.
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  118. Demling RH, Crawford G, Lind L, Read T. Restrictive pulmonary dysfunction caused by the grafted chest and abdominal burn. Crit Care Med. 1988 Aug; 16(8):743-7.
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  119. Lalonde C, Demling RH, Goad ME. Tissue inflammation without bacteria produces increased oxygen consumption and distant organ lipid peroxidation. Surgery. 1988 Jul; 104(1):49-56.
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  120. DeCamp MM, Demling RH. Posttraumatic multisystem organ failure. JAMA. 1988 Jul 22-29; 260(4):530-4.
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  121. Demling RH, Zhu D, Lalonde C. Early pulmonary and hemodynamic effects of a chest wall burn (effect of ibuprofen). Surgery. 1988 Jul; 104(1):10-7.
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  122. Demling RH, Read T, Lind LJ, Flanagan HL. Incidence and morbidity of extubation failure in surgical intensive care patients. Crit Care Med. 1988 Jun; 16(6):573-7.
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  123. Demling RH. Surgical critical care: whose responsibility is it? Bull Am Coll Surg. 1988 Feb; 73(2):59-60.
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  124. Demling RH, Lalonde C, Ryan P, Zhu DG, Liu YP. Endotoxemia produces an increase in arterial but not venous lipid peroxides in sheep. J Appl Physiol. 1988 Feb; 64(2):592-8.
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  125. Demling RH, Lalonde C. Topical ibuprofen decreases early postburn edema. Surgery. 1987 Nov; 102(5):857-61.
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  126. Lalonde C, Demling RH. The effect of complete burn wound excision and closure on postburn oxygen consumption. Surgery. 1987 Nov; 102(5):862-8.
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  127. Huang V, Figge H, Demling R. Haloperidol complications in burn patients. J Burn Care Rehabil. 1987 Jul-Aug; 8(4):269-73.
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  128. Demling RH. Smoke inhalation injury. Postgrad Med. 1987 Jul; 82(1):63-8.
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  129. Demling RH. Pulmonary edema: current concepts of pathophysiology, clinical significance, and methods of measurement. World J Surg. 1987 Apr; 11(2):147-53.
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  130. Demling RH. Fluid replacement in burned patients. Surg Clin North Am. 1987 Feb; 67(1):15-30.
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  131. Demling RH. Wound inflammatory mediators and multisystem organ failure. Prog Clin Biol Res. 1987; 236A:525-37.
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  132. Demling RH, Katz A, Lalonde C, Ryan P, Jin LJ. The immediate effect of burn wound excision on pulmonary function in sheep: the role of prostanoids, oxygen radicals, and chemoattractants. Surgery. 1987 Jan; 101(1):44-55.
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  133. Demling RH, Lalonde CC, Jin LJ, Albes J, Fiori N. The pulmonary and systemic response to recurrent endotoxemia in the adult sheep. Surgery. 1986 Nov; 100(5):876-83.
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  134. Demling RH, Lalonde C, Jin LJ, Katz A, Ryan P. Comparison of the postburn hyperdynamic state and changes in lung function (effect of wound bacterial content). Surgery. 1986 Nov; 100(5):828-35.
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  135. Demling RH. The cardiopulmonary effects of sepsis on the trauma patient. Crit Care Clin. 1986 Oct; 2(4):853-67.
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  136. Warner KG, Demling RH. The pathophysiology of free-fall injury. Ann Emerg Med. 1986 Sep; 15(9):1088-93.
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  137. Jin LJ, Lalonde C, Demling RH. Lung dysfunction after thermal injury in relation to prostanoid and oxygen radical release. J Appl Physiol. 1986 Jul; 61(1):103-12.
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  138. Rodrick ML, Wood JJ, O'Mahony JB, Davis CF, Grbic JT, Demling RH, Moss NM, Saporoschetz I, Jordan A, D'Eon P. Mechanisms of immunosuppression associated with severe nonthermal traumatic injuries in man: production of interleukin 1 and 2. J Clin Immunol. 1986 Jul; 6(4):310-8.
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  139. Demling RH, Lalonde C, Jin LJ, Ryan P, Fox R. Endotoxemia causes increased lung tissue lipid peroxidation in unanesthetized sheep. J Appl Physiol. 1986 Jun; 60(6):2094-100.
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  140. Demling RH. Postgraduate course: respiratory injury. Part III: Pulmonary dysfunction in the burn patient. J Burn Care Rehabil. 1986 May-Jun; 7(3):277-84.
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  141. Demling RH, Wenger H, Lalonde CC, Hechtman H, Wong C, West K. Endotoxin-induced prostanoid production by the burn wound can cause distant lung dysfunction. Surgery. 1986 Apr; 99(4):421-31.
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  142. Katz A, Ryan P, Lalonde C, West K, Demling R. Topical ibuprofen decreases thromboxane release from the endotoxin-stimulated burn wound. J Trauma. 1986 Feb; 26(2):157-62.
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  143. Ryan P, Katz A, Lalonde C, Jin LJ, Demling R. Effect of microvascular hydrostatic pressure and local prostanoid production on early and late postburn edema formation. J Burn Care Rehabil. 1986 Jan-Feb; 7(1):15-23.
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  144. Rodrick ML, Wood JJ, Grbic JT, O'Mahony JB, Davis CF, Moss NM, Blazar BA, Demling RH, Mannick JA. Defective IL-2 production in patients with severe burns and sepsis. Lymphokine Res. 1986; 5 Suppl 1:S75-80.
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  145. Demling RH. Effect of plasma and interstitial protein content on tissue edema formation. Curr Stud Hematol Blood Transfus. 1986; (53):36-52.
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  146. Wood JJ, O'Mahony JB, Rodrick ML, Eaton R, Demling RH, Mannick JA. Abnormalities of antibody production after thermal injury. An association with reduced interleukin 2 production. Arch Surg. 1986 Jan; 121(1):108-15.
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  147. Jin LJ, Lalonde C, Demling RH. Effect of anesthesia and positive pressure ventilation on early postburn hemodynamic instability. J Trauma. 1986 Jan; 26(1):26-33.
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  148. Demling RH, Wong C, Fox R, Hechtman H, Huval W. Relationship of increased lung serotonin levels to endotoxin-induced pulmonary hypertension in sheep. Effect of a serotonin antagonist. Am Rev Respir Dis. 1985 Dec; 132(6):1257-61.
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  149. Demling RH. Burns. N Engl J Med. 1985 Nov 28; 313(22):1389-98.
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  150. Demling RH, Wong C, Jin LJ, Hechtman H, Lalonde C, West K. Early lung dysfunction after major burns: role of edema and vasoactive mediators. J Trauma. 1985 Oct; 25(10):959-66.
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  151. Demling RH, Tortella B. The effect of lipid infusion on pulmonary function in burn patients with inhalation injury. J Burn Care Rehabil. 1985 May-Jun; 6(3):222-5.
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  152. Demling RH. Burns. Fluid and electrolyte management. Crit Care Clin. 1985 Mar; 1(1):27-45.
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  153. Wong C, Fox R, Demling RH. Effect of hydroxyl radical scavenging on endotoxin-induced lung injury. Surgery. 1985 Mar; 97(3):300-7.
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  154. Wenger H, Wong C, Demling RH. Pulmonary dysfunction secondary to soft-tissue endotoxin. Arch Surg. 1985 Feb; 120(2):159-65.
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  155. Palder SB, Wong C, Hood I, Wenger H, Mannick JA, Demling RH. Chemotactic activity of plasma and lung lymph in sheep with endotoxemia: effect of hydroxyl radical scavengers. J Surg Res. 1985 Feb; 38(2):162-72.
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  156. Demling RH, Wenger H, Hechtman H, Wong C. Role of subcutaneous tissue endotoxin in the production of prostanoid-induced lung injury: comparison with intravenous endotoxin response. Circ Shock. 1985; 17(2):147-61.
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  157. Wong C, Wenger H, Demling RH. Effect of a body burn on the lung response to endotoxin. J Trauma. 1985 Jan; 25(1):53-9.
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  158. Demling RH. Burn injury. Acute Care. 1985; 11(3-4):119-86.
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  159. O'Mahony JB, Palder SB, Wood JJ, McIrvine A, Rodrick ML, Demling RH, Mannick JA. Depression of cellular immunity after multiple trauma in the absence of sepsis. J Trauma. 1984 Oct; 24(10):869-75.
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  160. Demling RH. Effect of early burn excision and grafting on pulmonary function. J Trauma. 1984 Sep; 24(9):830-4.
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  161. Nerlich AG, Nerlich ML, Langer I, Demling RH. Release of amino-terminal procollagen peptides in paraquat-induced acute pulmonary fibrosis. Exp Mol Pathol. 1984 Jun; 40(3):311-9.
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  162. Demling RH, Kramer GC, Gunther R, Nerlich M. Effect of nonprotein colloid on postburn edema formation in soft tissues and lung. Surgery. 1984 May; 95(5):593-602.
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  163. Foulke GE, Fisher CJ, Demling RH. Effect of nitroprusside administration and sudden withdrawal on pulmonary vascular tone and lung fluid balance. Crit Care Med. 1984 May; 12(5):432-5.
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  164. Cahalane M, Demling RH. Early respiratory abnormalities from smoke inhalation. JAMA. 1984 Feb 10; 251(6):771-3.
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  165. Cohen SH, Hoeprich PD, Demling R, Gunther R, Merry JM, Franti CE, Miner DJ. Entry of four cephalosporins into the ovine lung. J Infect Dis. 1984 Feb; 149(2):264-70.
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  166. Demling RH, Kramer G, Harms B. Role of thermal injury-induced hypoproteinemia on fluid flux and protein permeability in burned and nonburned tissue. Surgery. 1984 Feb; 95(2):136-44.
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  167. Demling RH, Wong C, Wenger H. Effect of endotoxin on the integrity of the peripheral (soft tissue) microcirculation. Circ Shock. 1984; 12(3):191-202.
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  168. Wong C, Huval W, Hechtman H, Demling RH. Effect of hemorrhagic shock on endotoxin-induced pulmonary hypertension and increased vascular permeability in unanesthetized sheep. Circ Shock. 1984; 12(1):61-71.
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  169. Wong C, Flynn J, Demling RH. Role of oxygen radicals in endotoxin-induced lung injury. Arch Surg. 1984 Jan; 119(1):77-82.
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  170. Kramer GC, Harms BA, Bodai BI, Renkin EM, Demling RH. Effects of hypoproteinemia and increased vascular pressure on lung fluid balance in sheep. J Appl Physiol. 1983 Nov; 55(5):1514-22.
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  171. Demling RH. Fluid resuscitation after major burns. JAMA. 1983 Sep 16; 250(11):1438-40.
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  172. Cross CE, Forte TM, Gunther RA, Kramer GC, Lindgren FT, Demling R. Lipoprotein profiles in sheep plasma and lung lymph. Chest. 1983 May; 83(5 Suppl):93S-94S.
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  173. Demling RH, Nerlich M. Acute respiratory failure. Surg Clin North Am. 1983 Apr; 63(2):337-55.
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  174. Bodai BI, Harms BA, Nottingham PB, Zaiss C, Demling RH. The effect of ketamine on endotoxin-induced lung injury. Anesth Analg. 1983 Apr; 62(4):398-403.
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  175. Demling RH. Improved survival after massive burns. J Trauma. 1983 Mar; 23(3):179-84.
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  176. Flynn JT, Gee MH, Demling RH. Effects of anesthesia and surgery on prostanoid concentrations in plasma and pulmonary lymph. Prostaglandins Leukot Med. 1983 Feb; 10(2):213-20.
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  177. Nerlich M, Flynn J, Demling RH. Effect of thermal injury on endotoxin-induced lung injury. Surgery. 1983 Feb; 93(2):289-96.
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  178. Nerlich M, Gunther R, Demling RH. Resuscitation from hemorrhagic shock with hypertonic saline or lactated Ringer's (effect on the pulmonary and systemic microcirculations). Circ Shock. 1983; 10(2):179-88.
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  179. Wisner DH, Street D, Demling R. Effect of colloid versus crystalloid resuscitation on soft tissue edema formation. Curr Surg. 1983 Jan-Feb; 40(1):32-5.
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  180. Demling RH, Gunther R. Effect of diaphragmatic lymphatic contamination on caudal mediastinal node lymph flow in unanesthetized sheep. Lymphology. 1982 Dec; 15(4):163-7.
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  181. Kramer GC, Harms BA, Bodai BI, Demling RH, Renkin EM. Mechanisms for redistribution of plasma protein following acute protein depletion. Am J Physiol. 1982 Nov; 243(5):H803-9.
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  182. Demling RH. Management of acute respiratory failure. Compr Ther. 1982 Sep; 8(9):68-74.
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  183. Demling RH, Harms B, Kramer G, Gunther R. Acute versus sustained hypoproteinemia and posttraumatic pulmonary edema. Surgery. 1982 Jul; 92(1):79-86.
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  184. Foulke GE, Fisher CJ, Demling RH. Effect of nitroprusside on pulmonary hypertension and lung fluid balance after E. coli endotoxin. Crit Care Med. 1982 Jul; 10(7):427-31.
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  185. Gunther R, Zaiss C, Demling RH. Pulmonary microvascular response to prostacyclin (PGI2) infusion in unanesthetized sheep. J Appl Physiol. 1982 May; 52(5):1338-42.
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  186. Smith ME, Holcroft JW, Demling RH. Prostaglandin E1 and prostacyclin infusion decrease thromboxane production in endotoxin-induced lung injury. J Surg Res. 1982 Mar; 32(3):283-8.
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  187. Smith ME, Gunther R, Zaiss C, Demling RH. Prostaglandin infusion and endotoxin-induced lung injury. Arch Surg. 1982 Feb; 117(2):175-80.
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  188. Harms BA, Bodai BI, Kramer GC, Demling RH. Microvascular fluid and protein flux in pulmonary and systemic circulations after thermal injury. Microvasc Res. 1982 Jan; 23(1):77-86.
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  189. Demling RH. Role of prostaglandins in acute pulmonary microvascular injury. Ann N Y Acad Sci. 1982; 384:517-34.
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  190. Kramer GC, Gunther RA, Nerlich ML, Zweifach SS, Demling RH. Effect of dextran-70 on increased microvascular fluid and protein flux after thermal injury. Circ Shock. 1982; 9(5):529-41.
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  191. Flynn JT, Demling RH. Inhibition of endogenous thromboxane synthesis by exogenous prostacyclin during endotoxemia in conscious sheep. Adv Shock Res. 1982; 7:199-207.
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  192. Demling RH, Nerlich M. Animal research on hypovolemic shock and resuscitation: an update. Prog Clin Biol Res. 1982; 108:31-50.
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  193. Demling RH, Gunther R. Response of the soft tissue microcirculation to prostacyclin infusion. Prostaglandins Med. 1981 Dec; 7(6):489-98.
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  194. Carson SN, Demling RH, Esquivel CO. Aspirin failure in symptomatic atherosclerotic carotid artery disease. Surgery. 1981 Dec; 90(6):1084-92.
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  195. Kramer GC, Harms BA, Gunther RA, Renkin EM, Demling RH. The effects of hypoproteinemia on blood-to-lymph fluid transport in sheep lung. Circ Res. 1981 Nov; 49(5):1173-80.
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  196. Harms BA, Bodai BI, Smith M, Gunther R, Flynn J, Demling RH. Prostaglandin release and altered microvascular integrity after burn injury. J Surg Res. 1981 Oct; 31(4):274-80.
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  197. Demling RH, Smith M, Gunther R, Wandzilak T, Pederson NC. Use of a chronic prefemoral lymphatic fistula for monitoring systemic capillary integrity in unanesthetized sheep. J Surg Res. 1981 Aug; 31(2):136-44.
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  198. Carson S, Demling R, Esquivel C, Talken L, Tillman P. Testing and treatment of arterial graft thrombosis. Am J Surg. 1981 Jul; 142(1):137-43.
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  199. Harms BA, Kramer GC, Bodai BI, Demling RH. Effect of hypoproteinemia on pulmonary and soft tissue edema formation. Crit Care Med. 1981 Jul; 9(7):503-8.
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  200. Smith ME, Gunther R, Gee M, Flynn J, Demling RH. Leukocytes, platelets, and thromboxane A2 in endotoxin-induced lung injury. Surgery. 1981 Jul; 90(1):102-7.
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  201. Demling RH, Smith M, Gunther R, Flynn JT, Gee MH. Pulmonary injury and prostaglandin production during endotoxemia in conscious sheep. Am J Physiol. 1981 Mar; 240(3):H348-53.
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  202. Demling RH, Smith M, Gunther R, Gee M, Flynn J. The effect of prostacyclin infusion on endotoxin-induced lung injury. Surgery. 1981 Feb; 89(2):257-63.
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  203. Demling RH, Proctor R, Grossman J, Duy N, Starling J. Lung injury and lung lysosomal enzyme release during endotoxemia. J Surg Res. 1981 Feb; 30(2):135-41.
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  204. Demling RH, Smith M, Gunther R, Wandzilak T. Endotoxin-induced lung injury in unanesthetized sheep: effect of methylprednisolone. Circ Shock. 1981; 8(3):351-60.
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  205. Smith M, Gunther R, Zaiss C, Flynn J, Demling R. Pulmonary microvascular injury from lipoxygenase infusion: comparison with endotoxemia. Circ Shock. 1981; 8(6):647-56.
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  206. Demling RH. General surgery-epitomes of progress: burn management. West J Med. 1980 Dec; 133(6):508-9.
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  207. Demling RH. The pathogenesis of respiratory failure after trauma and sepsis. Surg Clin North Am. 1980 Dec; 60(6):1373-90.
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  208. Grossman JE, Demling RH, Duy ND, Mosher DF. Response of plasma fibronectin to major body burn. J Trauma. 1980 Nov; 20(11):967-70.
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  209. Demling RH, Duy N, Manohar M, Proctor R. Comparison between lung fluid filtration rate and measured starling forces after hemorrhagic and endotoxic shock. J Trauma. 1980 Oct; 20(10):856-60.
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  210. Demling RH, Duy N, Manohar M, Will JA, Hopps B, Starling J. Changes in plasma and lung lymph lysosomal enzymes after major thermal injury. J Trauma. 1980 Sep; 20(9):791-4.
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  211. Demling RH, Manohar M, Will JA. Response of the pulmonary microcirculation to fluid loading after hemorrhagic shock and resuscitation. Surgery. 1980 May; 87(5):552-9.
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  212. Demling RH, Buerstatte WR, Perea A. Management of hot tar burns. J Trauma. 1980 Mar; 20(3):242.
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  213. Demling RH, Manohar M, Will JA. Relationship between the measured and calculated colloid osmotic pressure of plasma and lung lymph in the sheep. Lymphology. 1980 Mar; 13(1):18-23.
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  214. Demling RH, Proctor R, Duy N, Starling JR. Lung lysosomal enzyme release during hemorrhagic shock and endotoxemia. J Surg Res. 1980 Mar; 28(3):269-79.
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  215. Demling RH. Lung fluid and protein dynamics during hemorrhagic shock, resuscitation, and recovery. Circ Shock. 1980; 7(2):149-61.
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  216. Demling RH, Maly J. The treatment of burn patients in a laminar airflow environment. Ann N Y Acad Sci. 1980; 353:294-9.
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  217. Demling RH, Proctor R, Grossman J, Duy N, Starling J. Comparison of the systemic and pulmonary vascular response to endotoxin with plasma and lung lymph lysosomal enzyme release: effect of steroid pretreatment. Circ Shock. 1980; 7(3):317-31.
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  218. Demling RH, Will JA, Perea A. Effect of albumin infusion on pulmonary microvascular fluid and protein transport. J Surg Res. 1979 Nov; 27(5):321-6.
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  219. Demling RH, Manohar M, Will JA. Relation between pulmonary transvascular fluid filtration rate and measured Starling's forces after major burn. Chest. 1979 Oct; 76(4):448-52.
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  220. Niehaus G, Will JA, Demling RH. Lactic dehydrogenase activity in lung lymph during hemorrhagic shock, resuscitation and recovery. Lymphology. 1979 Sep; 12(3):158-64.
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  221. Demling RH, Manohar M, Will JA, Belzer FO. The effect of plasma oncotic pressure on the pulmonary microcirculation after hemorrhagic shock. Surgery. 1979 Aug; 86(2):323-8.
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  222. Demling RH. Correlation of changes in body weight and pulmonary vascular pressures with lung water accumulation during fluid overload. Crit Care Med. 1979 Apr; 7(4):153-6.
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  223. Demling RH, Niehaus G, Perea A, Will JA. Effect of burn-induced hypoproteinemia on pulmonary transvascular fluid filtration rate. Surgery. 1979 Mar; 85(3):339-43.
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  224. Demling RH, Niehaus G, Will JA. Pulmonary microvascular response to hemorrhagic shock, resuscitation, and recovery. J Appl Physiol. 1979 Mar; 46(3):498-503.
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  225. Demling RH, Mazess RB, Wolberg W. The effect of immediate and delayed cold immersion on burn edema formation and resorption. J Trauma. 1979 Jan; 19(1):56-60.
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  226. Demling RH, Mazess R, Hanson J, Wolberg W. Effect of heparin on edema after second- and third-degree burns. J Surg Res. 1979 Jan; 26(1):27-32.
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  227. Demling RH, Will JA. The effect of furosemide on the pulmonary transvascular fluid filtration rate. Crit Care Med. 1978 Sep-Oct; 6(5):317-9.
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  228. Demling RH, Perea A, Maly J, Moylan JA, Jarrett F, Balish E. The use of a laminar airflow isolation system for the treatment of major burns. Am J Surg. 1978 Sep; 136(3):375-8.
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  229. Gorin AB, Weidner WJ, Demling RH, Staub NC. Noninvasive measurement of pulmonary transvascular protein flux in sheep. J Appl Physiol. 1978 Aug; 45(2):225-33.
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  230. Demling RH, Manohar M, Will J. The effect of glucagon on the pulmonary transvascular fluid filtration rate. Chest. 1978 Aug; 74(2):196-9.
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  231. Perea A, Maly J, Demling R. Epidemiology of burn injury in rural Wisconsin. Wis Med J. 1978 Jul; 77(7):62-3.
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  232. Demling RH, Ellerbe S, Lowe NJ. Burn unit management of toxic epidermal necrolysis. Arch Surg. 1978 Jun; 113(6):758-9.
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  233. Jarrett F, Ellerbe S, Demling R. Acute leukopenia during topical burn therapy with silver sulfadiazine. Am J Surg. 1978 Jun; 135(6):818-9.
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  234. Demling RH, Will JA, Belzer FO. Effect of major thermal injury on the pulmonary microcirculation. Surgery. 1978 Jun; 83(6):746-51.
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  235. Demling RH, Ellerbe S, Jarrett F. Ketamine anesthesia for tangenital excision of burn eschar: a burn unit procedure. J Trauma. 1978 Apr; 18(4):269-70.
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  236. Demling RH, Mazess RB, Witt RM, Wolberg WH. The study of burn wound edema using dichromatic absorptiometry. J Trauma. 1978 Feb; 18(2):124-8.
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  237. Holcroft JW, Demling RH, Jaffe BM. Concentration and flow of prostaglandins in pulmonary lymph in sheep resuscitated from hemorrhagic shock. Surg Forum. 1978; 29:52-4.
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  238. Demling R, Niehaus G, Will J, Belzer FO. Effect of hemorrhagic shock and resuscitation on pulmonary microvascular integrity. Surg Forum. 1978; 29:196-8.
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  239. Demling RH, Moylan JA, Ellerbe S, Jarrett F. Experience with laminar airflow in the management of major burns. Wis Med J. 1977 Dec; 76(12):S 149-50.
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  240. Bland RD, Demling RH, Selinger SL, Staub NC. Effects of alveolar hypoxia on lung fluid and protein transport in unanesthetized sheep. Circ Res. 1977 Mar; 40(3):269-74.
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  241. Demling R, Wolberg WH. Effect of heparin and cold immersion on burn edema. Surg Forum. 1977; 28:29-30.
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  242. Demling RH. The lung as a reservoir for fluid. Int Anesthesiol Clin. 1977; 15(4):107-23.
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  243. Clark OH, Demling R. Management of thyroid nodules in the elderly. Am J Surg. 1976 Nov; 132(5):615-9.
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  244. Vreim CR, Snashall PD, Demling RH, Staub NC. Lung lymph and free interstitial fluid protein composition in sheep with edema. Am J Physiol. 1976 Jun; 230(6):1650-3.
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  245. Demling RH, Hicks RE, Edmunds LH. Changes in extravascular lung water during venovenous perfusion. J Thorac Cardiovasc Surg. 1976 Feb; 71(2):291-4.
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  246. Selinger SL, Bland RD, Demling RH, Staub NC. Distribution volumes of [131I]albumin, [14C]sucrose, and 36Cl in sheep lung. J Appl Physiol. 1975 Nov; 39(5):773-9.
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  247. Staub NC, Bland RD, Brigham KL, Demling R, Erdmann AJ, Woolverton WC. Preparation of chronic lung lymph fistulas in sheep. J Surg Res. 1975 Nov; 19(5):315-20.
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  248. Christensen NM, Demling R, Mathewson C. Unusual manifestations of pancreatic pseudocysts and their surgical management. Am J Surg. 1975 Aug; 130(2):199-205.
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  249. Demling RH, Staub NC, Edmunds LH. Effect of end-expiratory airway pressure on accumulation of extravascular lung water. J Appl Physiol. 1975 May; 38(5):907-12.
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  250. Demling RH, Selinger SL, Bland RD, Staub NC. Effect of acute hemorrhagic shock on pulmonary microvascular fluid filtration and protein permeability in sheep. Surgery. 1975 Apr; 77(4):512-9.
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  251. Demling RH, Salvatierra O, Belzer FO. Intestinal necrosis and perforation after renal transplantation. Arch Surg. 1975 Mar; 110(3):251-3.
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  252. Demling RH, Edmunds LH. Effect of continuous positive airway pressure on extravascular lung water. Surg Forum. 1973; 24:226-8.
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