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Pedram Hamrah, M.D.

TitleAssistant Professor of Ophthalmology
InstitutionMassachusetts Eye and Ear Infirmary
DepartmentOphthalmology
AddressMassachusetts Eye & Ear Infrm
Ophthalmology, Cornea & Refractive Surgery Service
243 Charles St
Boston MA 02114
Phone617/573-6897
Fax617/573-4300

 Mentoring 
 current student opportunities
Available: 06/30/11, Expires: 06/30/15

There is mounting evidence that APC and T cell recruitment to peripheral tissues, including the cornea, is highly regulated and depends on recruitment signals that are either tissue-specific or inflammation-induced, or both. Neither the molecular nature of these recruitment signals nor the repertoire of traffic molecules that enable APC and T cells to detect and respond to such recruitment signals are well understood. The current proposal is a step toward understanding the tissue, cellular and molecular factors involved in the recruitment, turnover, egress and function of corneal APCs, as well as mechanisms involved in the recruitment of T cells to the cornea that could potentially lead to corneal graft rejection. We propose a more systematic in vivo approach by studying the migratory properties of APCs in the steady state, inflammation, and after corneal transplantation. Identification of the critical pathway(s) of APC and effector T cell migration to the cornea could lead to novel highly specific immunomodulatory strategies for immunotherapy, through modulation of APC and T cell migration and function. The students would be involved in translational science, image acquisition and analysis, immunohistochemistry and confocal microscopy.

Available: 08/01/12, Expires: 07/31/14

To study the immunobiology and trafficking mechanisms of corneal antigen presenting cells in inflammatory corneal diseases


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Qazi Y, Aggarwal S, Hamrah P. Image-guided evaluation and monitoring of treatment response in patients with dry eye disease. Graefes Arch Clin Exp Ophthalmol. 2014 Apr 4.
    View in: PubMed
  2. Amparo F, Hamrah P, Schaumberg DA, Dana R. The value of tear osmolarity as a metric in evaluating the response to dry eye therapy in the clinic and in clinical trials. Am J Ophthalmol. 2014 Apr; 157(4):915-6.
    View in: PubMed
  3. Mott KR, Allen SJ, Zandian M, Akbari O, Hamrah P, Maazi H, Wechsler SL, Sharpe AH, Freeman GJ, Ghiasi H. Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses. PLoS One. 2014; 9(1):e87617.
    View in: PubMed
  4. Qazi Y, Hamrah P. Corneal Allograft Rejection: Immunopathogenesis to Therapeutics. J Clin Cell Immunol. 2013 Nov 20; 2013(Suppl 9).
    View in: PubMed
  5. Villani E, Baudouin C, Efron N, Hamrah P, Kojima T, Patel SV, Pflugfelder SC, Zhivov A, Dogru M. In vivo confocal microscopy of the ocular surface: from bench to bedside. Curr Eye Res. 2014 Mar; 39(3):213-31.
    View in: PubMed
  6. Stapleton F, Marfurt C, Golebiowski B, Rosenblatt M, Bereiter D, Begley C, Dartt D, Gallar J, Belmonte C, Hamrah P, Willcox M. The TFOS International Workshop on Contact Lens Discomfort: Report of the Subcommittee on Neurobiology. Invest Ophthalmol Vis Sci. 2013; 54(11):TFOS71-97.
    View in: PubMed
  7. Amparo F, Jin Y, Hamrah P, Schaumberg DA, Dana R. What is the Value of Incorporating Tear Osmolarity Measurement in Assessing Patient Response to Therapy in Dry Eye Disease? Am J Ophthalmol. 2014 Jan; 157(1):69-77.e2.
    View in: PubMed
  8. Qazi Y, Hamrah P. Gene therapy in corneal transplantation. Semin Ophthalmol. 2013 Sep-Nov; 28(5-6):287-300.
    View in: PubMed
  9. Yamaguchi T, Turhan A, Harris DL, Hu K, Prüss H, von Andrian U, Hamrah P. Bilateral nerve alterations in a unilateral experimental neurotrophic keratopathy model: a lateral conjunctival approach for trigeminal axotomy. PLoS One. 2013; 8(8):e70908.
    View in: PubMed
  10. Cheng SF, Dastjerdi MH, Ferrari G, Okanobo A, Amparo F, Stevenson W, Hamrah P, Nallasamy N, Dana R, Bower KS, Ryan DS. Reply. Am J Ophthalmol. 2013 Jul; 156(1):204-5.
    View in: PubMed
  11. Amparo F, Dastjerdi MH, Okanobo A, Ferrari G, Smaga L, Hamrah P, Jurkunas U, Schaumberg DA, Dana R. Topical interleukin 1 receptor antagonist for treatment of dry eye disease: a randomized clinical trial. JAMA Ophthalmol. 2013 Jun 1; 131(6):715-23.
    View in: PubMed
  12. Schrems-Hoesl LM, Schrems WA, Cruzat A, Shahatit BM, Bayhan HA, Jurkunas UV, Hamrah P. Cellular and subbasal nerve alterations in early stage Fuchs' endothelial corneal dystrophy: an in vivo confocal microscopy study. Eye (Lond). 2013 Jan; 27(1):42-9.
    View in: PubMed
  13. Hamrah P, Cruzat A, Dastjerdi MH, Prüss H, Zheng L, Shahatit BM, Bayhan HA, Dana R, Pavan-Langston D. Unilateral herpes zoster ophthalmicus results in bilateral corneal nerve alteration: an in vivo confocal microscopy study. Ophthalmology. 2013 Jan; 120(1):40-7.
    View in: PubMed
  14. Cheng SF, Dastjerdi MH, Ferrari G, Okanobo A, Bower KS, Ryan DS, Amparo F, Stevenson W, Hamrah P, Nallasamy N, Dana R. Short-term topical bevacizumab in the treatment of stable corneal neovascularization. Am J Ophthalmol. 2012 Dec; 154(6):940-948.e1.
    View in: PubMed
  15. Alhatem A, Cavalcanti B, Hamrah P. In vivo confocal microscopy in dry eye disease and related conditions. Semin Ophthalmol. 2012 Sep; 27(5-6):143-53.
    View in: PubMed
  16. Shukla AN, Cruzat A, Hamrah P. Confocal microscopy of corneal dystrophies. Semin Ophthalmol. 2012 Sep; 27(5-6):107-16.
    View in: PubMed
  17. Hamrah P, Sahin A, Dastjerdi MH, Shahatit BM, Bayhan HA, Dana R, Pavan-Langston D. Cellular changes of the corneal epithelium and stroma in herpes simplex keratitis: an in vivo confocal microscopy study. Ophthalmology. 2012 Sep; 119(9):1791-7.
    View in: PubMed
  18. Sahin A, Hamrah P. Acute Herpetic Keratitis: What is the Role for Ganciclovir Ophthalmic Gel? Ophthalmol Eye Dis. 2012; 4:23-34.
    View in: PubMed
  19. Sahin A, Hamrah P. Clinically relevant biometry. Curr Opin Ophthalmol. 2012 Jan; 23(1):47-53.
    View in: PubMed
  20. Kurbanyan K, Hoesl LM, Schrems WA, Hamrah P. Corneal nerve alterations in acute Acanthamoeba and fungal keratitis: an in vivo confocal microscopy study. Eye (Lond). 2012 Jan; 26(1):126-32.
    View in: PubMed
  21. Hamrah P, Alipour F, Jiang S, Sohn JH, Foulks GN. Optimizing evaluation of Lissamine Green parameters for ocular surface staining. Eye (Lond). 2011 Nov; 25(11):1429-34.
    View in: PubMed
  22. Cruzat A, Witkin D, Baniasadi N, Zheng L, Ciolino JB, Jurkunas UV, Chodosh J, Pavan-Langston D, Dana R, Hamrah P. Inflammation and the nervous system: the connection in the cornea in patients with infectious keratitis. Invest Ophthalmol Vis Sci. 2011 Jul; 52(8):5136-43.
    View in: PubMed
  23. Smolyar AE, Hamrah P. Bilateral posterior ischemic optic neuropathy in a patient with severe diabetic ketoacidosis. Case Report Ophthalmol. 2011; 2(1):91-4.
    View in: PubMed
  24. Allen SJ, Hamrah P, Gate D, Mott KR, Mantopoulos D, Zheng L, Town T, Jones C, von Andrian UH, Freeman GJ, Sharpe AH, BenMohamed L, Ahmed R, Wechsler SL, Ghiasi H. The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1. J Virol. 2011 May; 85(9):4184-97.
    View in: PubMed
  25. Kumar RL, Cruzat A, Hamrah P. Current state of in vivo confocal microscopy in management of microbial keratitis. Semin Ophthalmol. 2010 Sep-Nov; 25(5-6):166-70.
    View in: PubMed
  26. Mantopoulos D, Cruzat A, Hamrah P. In vivo imaging of corneal inflammation: new tools for clinical practice and research. Semin Ophthalmol. 2010 Sep-Nov; 25(5-6):178-85.
    View in: PubMed
  27. Cruzat A, Pavan-Langston D, Hamrah P. In vivo confocal microscopy of corneal nerves: analysis and clinical correlation. Semin Ophthalmol. 2010 Sep-Nov; 25(5-6):171-7.
    View in: PubMed
  28. Hamrah P, Cruzat A, Dastjerdi MH, Zheng L, Shahatit BM, Bayhan HA, Dana R, Pavan-Langston D. Corneal sensation and subbasal nerve alterations in patients with herpes simplex keratitis: an in vivo confocal microscopy study. Ophthalmology. 2010 Oct; 117(10):1930-6.
    View in: PubMed
  29. Hamrah P, Singh PK, Hoesl L, Tezel TH. Development of crystalline keratopathy after intravitreal injections of pegaptanib. Eye (Lond). 2010 Sep; 24(9):1527-8.
    View in: PubMed
  30. Dastjerdi MH, Hamrah P, Dana R. High-frequency topical cyclosporine 0.05% in the treatment of severe dry eye refractory to twice-daily regimen. Cornea. 2009 Dec; 28(10):1091-6.
    View in: PubMed
  31. Hamrah P, Haskova Z, Taylor AW, Zhang Q, Ksander BR, Dana MR. Local treatment with alpha-melanocyte stimulating hormone reduces corneal allorejection. Transplantation. 2009 Jul 27; 88(2):180-7.
    View in: PubMed
  32. Dastjerdi MH, Al-Arfaj KM, Nallasamy N, Hamrah P, Jurkunas UV, Pineda R, Pavan-Langston D, Dana R. Topical bevacizumab in the treatment of corneal neovascularization: results of a prospective, open-label, noncomparative study. Arch Ophthalmol. 2009 Apr; 127(4):381-9.
    View in: PubMed
  33. Hamrah P, Pavan-Langston D, Dana R. Herpes simplex keratitis and dendritic cells at the crossroads: lessons from the past and a view into the future. Int Ophthalmol Clin. 2009; 49(1):53-62.
    View in: PubMed
  34. Thiagalingam S, Tarongoy P, Hamrah P, Lobo AM, Nagao K, Barsam C, Bellows R, Pineda R. Complications of cosmetic iris implants. J Cataract Refract Surg. 2008 Jul; 34(7):1222-4.
    View in: PubMed
  35. Chen L, Hamrah P, Cursiefen C, Zhang Q, Pytowski B, Streilein JW, Dana MR. Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity. 2004. Ocul Immunol Inflamm. 2007 May-Jun; 15(3):275-8.
    View in: PubMed
  36. Jin Y, Shen L, Chong EM, Hamrah P, Zhang Q, Chen L, Dana MR. The chemokine receptor CCR7 mediates corneal antigen-presenting cell trafficking. Mol Vis. 2007; 13:626-34.
    View in: PubMed
  37. Hamrah P, Yamagami S, Liu Y, Zhang Q, Vora SS, Lu B, Gerard CJ, Dana MR. Deletion of the chemokine receptor CCR1 prolongs corneal allograft survival. Invest Ophthalmol Vis Sci. 2007 Mar; 48(3):1228-36.
    View in: PubMed
  38. Hamrah P, Dana MR. Corneal antigen-presenting cells. Chem Immunol Allergy. 2007; 92:58-70.
    View in: PubMed
  39. Cursiefen C, Chen L, Saint-Geniez M, Hamrah P, Jin Y, Rashid S, Pytowski B, Persaud K, Wu Y, Streilein JW, Dana R. Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision. Proc Natl Acad Sci U S A. 2006 Jul 25; 103(30):11405-10.
    View in: PubMed
  40. Hamrah P, Ritterband D, Seedor J, Eiferman RA. Ocular infection secondary to gemella. Graefes Arch Clin Exp Ophthalmol. 2006 Jul; 244(7):891-2.
    View in: PubMed
  41. Barabino S, Hamrah P, Serapião dos Santos M. Young investigators. Ocul Surf. 2005 Oct; 3(4):215-6.
    View in: PubMed
  42. Yamagami S, Hamrah P, Zhang Q, Liu Y, Huq S, Dana MR. Early ocular chemokine gene expression and leukocyte infiltration after high-risk corneal transplantation. Mol Vis. 2005; 11:632-40.
    View in: PubMed
  43. Yamagami S, Hamrah P, Miyamoto K, Miyazaki D, Dekaris I, Dawson T, Lu B, Gerard C, Dana MR. CCR5 chemokine receptor mediates recruitment of MHC class II-positive Langerhans cells in the mouse corneal epithelium. Invest Ophthalmol Vis Sci. 2005 Apr; 46(4):1201-7.
    View in: PubMed
  44. Hamrah P. High-risk penetrating keratoplasty. Arch Soc Esp Oftalmol. 2005 Jan; 80(1):5-7.
    View in: PubMed
  45. Hamrah P, Chen L, Cursiefen C, Zhang Q, Joyce NC, Dana MR. Expression of vascular endothelial growth factor receptor-3 (VEGFR-3) on monocytic bone marrow-derived cells in the conjunctiva. Exp Eye Res. 2004 Oct; 79(4):553-61.
    View in: PubMed
  46. Chen L, Hamrah P, Cursiefen C, Zhang Q, Pytowski B, Streilein JW, Dana MR. Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity. Nat Med. 2004 Aug; 10(8):813-5.
    View in: PubMed
  47. Hamrah P, Liu Y, Zhang Q, Dana MR. Alterations in corneal stromal dendritic cell phenotype and distribution in inflammation. Arch Ophthalmol. 2003 Aug; 121(8):1132-40.
    View in: PubMed
  48. Hamrah P, Huq SO, Liu Y, Zhang Q, Dana MR. Corneal immunity is mediated by heterogeneous population of antigen-presenting cells. J Leukoc Biol. 2003 Aug; 74(2):172-8.
    View in: PubMed
  49. Gockel I, Lord RV, Bremner CG, Crookes PF, Hamrah P, DeMeester TR. The hypertensive lower esophageal sphincter: a motility disorder with manometric features of outflow obstruction. J Gastrointest Surg. 2003 Jul-Aug; 7(5):692-700.
    View in: PubMed
  50. Hamrah P, Chen L, Zhang Q, Dana MR. Novel expression of vascular endothelial growth factor receptor (VEGFR)-3 and VEGF-C on corneal dendritic cells. Am J Pathol. 2003 Jul; 163(1):57-68.
    View in: PubMed
  51. Hamrah P, Liu Y, Zhang Q, Dana MR. The corneal stroma is endowed with a significant number of resident dendritic cells. Invest Ophthalmol Vis Sci. 2003 Feb; 44(2):581-9.
    View in: PubMed
  52. Qian Y, Hamrah P, Boisgerault F, Yamagami S, Vora S, Benichou G, Dana MR. Mechanisms of immunotherapeutic intervention by anti-CD154 (CD40L) antibody in high-risk corneal transplantation. J Interferon Cytokine Res. 2002 Dec; 22(12):1217-25.
    View in: PubMed
  53. Hamrah P, Zhang Q, Liu Y, Dana MR. Novel characterization of MHC class II-negative population of resident corneal Langerhans cell-type dendritic cells. Invest Ophthalmol Vis Sci. 2002 Mar; 43(3):639-46.
    View in: PubMed
  54. Liu Y, Hamrah P, Zhang Q, Taylor AW, Dana MR. Draining lymph nodes of corneal transplant hosts exhibit evidence for donor major histocompatibility complex (MHC) class II-positive dendritic cells derived from MHC class II-negative grafts. J Exp Med. 2002 Jan 21; 195(2):259-68.
    View in: PubMed
  55. Hamrah P, Zhang Q, Dana MR. Expression of vascular endothelial growth factor receptor-3 (VEGFR-3) in the conjunctiva--a potential link between lymphangiogenesis and leukocyte trafficking on the ocular surface. Adv Exp Med Biol. 2002; 506(Pt B):851-60.
    View in: PubMed
  56. Dana MR, Hamrah P. Role of immunity and inflammation in corneal and ocular surface disease associated with dry eye. Adv Exp Med Biol. 2002; 506(Pt B):729-38.
    View in: PubMed
  57. Dana MR, Qian Y, Hamrah P. Twenty-five-year panorama of corneal immunology: emerging concepts in the immunopathogenesis of microbial keratitis, peripheral ulcerative keratitis, and corneal transplant rejection. Cornea. 2000 Sep; 19(5):625-43.
    View in: PubMed
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