Pedram Hamrah, M.D.
|Title||Assistant Professor of Ophthalmology|
|Institution||Massachusetts Eye and Ear Infirmary|
|Address||Massachusetts Eye & Ear Infrm|
Ophthalmology, Cornea & Refractive Surgery Service
243 Charles St
Boston MA 02114
Available: 06/30/11, Expires: 06/30/15
There is mounting evidence that APC and T cell recruitment to peripheral tissues, including the cornea, is highly regulated and depends on recruitment signals that are either tissue-specific or inflammation-induced, or both. Neither the molecular nature of these recruitment signals nor the repertoire of traffic molecules that enable APC and T cells to detect and respond to such recruitment signals are well understood. The current proposal is a step toward understanding the tissue, cellular and molecular factors involved in the recruitment, turnover, egress and function of corneal APCs, as well as mechanisms involved in the recruitment of T cells to the cornea that could potentially lead to corneal graft rejection. We propose a more systematic in vivo approach by studying the migratory properties of APCs in the steady state, inflammation, and after corneal transplantation. Identification of the critical pathway(s) of APC and effector T cell migration to the cornea could lead to novel highly specific immunomodulatory strategies for immunotherapy, through modulation of APC and T cell migration and function. The students would be involved in translational science, image acquisition and analysis, immunohistochemistry and confocal microscopy.
Available: 08/01/12, Expires: 07/31/14
To study the immunobiology and trafficking mechanisms of corneal antigen presenting cells in inflammatory corneal diseases
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