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Last Name
Institution

Ellis Leonard Reinherz, M.D.

TitleProfessor of Medicine
InstitutionDana-Farber Cancer Institute
DepartmentMedicine
AddressDana Farber Cancer Institute
HIM - Rm 419
44 Binney St
Boston MA 02115
Phone617/632-3412
Fax617/632-3351

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Choi YI, Duke-Cohan JS, Chen W, Liu B, Rossy J, Tabarin T, Ju L, Gui J, Gaus K, Zhu C, Reinherz EL. Dynamic control of ß1 integrin adhesion by the plexinD1-sema3E axis. Proc Natl Acad Sci U S A. 2014 Jan 7; 111(1):379-84.
    View in: PubMed
  2. Choi YI, Duke-Cohan JS, Tan J, Gui J, Singh MK, Epstein JA, Reinherz EL. Plxnd1 expression in thymocytes regulates their intrathymic migration while that in thymic endothelium impacts medullary topology. Front Immunol. 2013; 4:392.
    View in: PubMed
  3. Kim M, Song L, Moon J, Sun ZY, Bershteyn A, Hanson M, Cain D, Goka S, Kelsoe G, Wagner G, Irvine D, Reinherz EL. Immunogenicity of Membrane-bound HIV-1 gp41 Membrane-proximal External Region (MPER) Segments Is Dominated by Residue Accessibility and Modulated by Stereochemistry. J Biol Chem. 2013 Nov 1; 288(44):31888-901.
    View in: PubMed
  4. Olsen LR, Kudahl UJ, Simon C, Sun J, Schönbach C, Reinherz EL, Zhang GL, Brusic V. BlockLogo: Visualization of peptide and sequence motif conservation. J Immunol Methods. 2013 Dec 31; 400-401:37-44.
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  5. Kang YJ, Zeng W, Song W, Reinhold B, Choi J, Brusic V, Yamashita T, Munshi A, Li C, Minvielle S, Anderson KC, Munshi N, Reinherz EL, Sasada T. Identification of human leucocyte antigen (HLA)-A*0201-restricted cytotoxic T lymphocyte epitopes derived from HLA-DOß as a novel target for multiple myeloma. Br J Haematol. 2013 Nov; 163(3):343-51.
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  6. Kung PC, Goldstein G, Reinherz EL, Schlossman SF. Pillars article: monoclonal antibodies defining distinctive human T cell surface antigens. Science. 1979. 206: 347-349. J Immunol. 2013 Jun 1; 190(11):5351-3.
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  7. Reinherz EL, Kung PC, Goldstein G, Schlossman SF. Pillars article: separation of functional subsets of human T cells by a monoclonal antibody. Proc. Natl. Acad. Sci. 1979. 76: 4061-4065. J Immunol. 2013 Jun 1; 190(11):5346-50.
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  8. Watkins JD, Sholukh AM, Mukhtar MM, Siddappa NB, Lakhashe SK, Kim M, Reinherz EL, Gupta S, Forthal DN, Sattentau QJ, Villinger F, Corti D, Ruprecht RM. Anti-HIV IgA isotypes: differential virion capture and inhibition of transcytosis are linked to prevention of mucosal R5 SHIV transmission. AIDS. 2013 Jun 1; 27(9):F13-20.
    View in: PubMed
  9. Wang JH, Reinherz EL. Revisiting the putative TCR Ca dimerization model through structural analysis. Front Immunol. 2013; 4:16.
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  10. Wang JH, Reinherz EL. The structural basis of aß T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function. Immunol Rev. 2012 Nov; 250(1):102-19.
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  11. Lank SM, Golbach BA, Creager HM, Wiseman RW, Keskin DB, Reinherz EL, Brusic V, O'Connor DH. Ultra-high resolution HLA genotyping and allele discovery by highly multiplexed cDNA amplicon pyrosequencing. BMC Genomics. 2012; 13:378.
    View in: PubMed
  12. Riemer AB, Keskin DB, Reinherz EL. Identification and validation of reference genes for expression studies in human keratinocyte cell lines treated with and without interferon-? - a method for qRT-PCR reference gene determination. Exp Dermatol. 2012 Aug; 21(8):625-9.
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  13. Reinherz EL. Pharmacology: A false sense of non-self. Nature. 2012 Jun 28; 486(7404):479-81.
    View in: PubMed
  14. Kim ST, Shin Y, Brazin K, Mallis RJ, Sun ZY, Wagner G, Lang MJ, Reinherz EL. TCR Mechanobiology: Torques and Tunable Structures Linked to Early T Cell Signaling. Front Immunol. 2012; 3:76.
    View in: PubMed
  15. Olsen LR, Zhang GL, Keskin DB, Reinherz EL, Brusic V. Conservation analysis of dengue virus T-cell epitope-based vaccine candidates using Peptide block entropy. Front Immunol. 2011; 2:69.
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  16. Keskin DB, Reinhold B, Lee SY, Zhang G, Lank S, O'Connor DH, Berkowitz RS, Brusic V, Kim SJ, Reinherz EL. Direct identification of an HPV-16 tumor antigen from cervical cancer biopsy specimens. Front Immunol. 2011; 2:75.
    View in: PubMed
  17. DeLuca DS, Keskin DB, Zhang GL, Reinherz EL, Brusic V. PB1-F2 Finder: scanning influenza sequences for PB1-F2 encoding RNA segments. BMC Bioinformatics. 2011 Nov 30; 12 Suppl 13:S6.
    View in: PubMed
  18. Olsen LR, Zhang GL, Reinherz EL, Brusic V. FLAVIdB: A data mining system for knowledge discovery in flaviviruses with direct applications in immunology and vaccinology. Immunome Res. 2011; 7(3):1-9.
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  19. Wang JH, Reinherz EL. A new angle on TCR activation. Immunity. 2011 Nov 23; 35(5):658-60.
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  20. Kim M, Sun ZY, Rand KD, Shi X, Song L, Cheng Y, Fahmy AF, Majumdar S, Ofek G, Yang Y, Kwong PD, Wang JH, Engen JR, Wagner G, Reinherz EL. Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization. Nat Struct Mol Biol. 2011 Nov; 18(11):1235-43.
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  21. Touma M, Keskin DB, Shiroki F, Saito I, Koyasu S, Reinherz EL, Clayton LK. Impaired B cell development and function in the absence of IkappaBNS. J Immunol. 2011 Oct 15; 187(8):3942-52.
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  22. Zhang GL, Lin HH, Keskin DB, Reinherz EL, Brusic V. Dana-Farber repository for machine learning in immunology. J Immunol Methods. 2011 Nov 30; 374(1-2):18-25.
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  23. Anderson KS, Zeng W, Sasada T, Choi J, Riemer AB, Su M, Drakoulakos D, Kang YJ, Brusic V, Wu C, Reinherz EL. Impaired tumor antigen processing by immunoproteasome-expressing CD40-activated B cells and dendritic cells. Cancer Immunol Immunother. 2011 Jun; 60(6):857-67.
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  24. Zhou B, Chen Q, Mallis RJ, Zhang H, Liu JH, Reinherz EL, Wang JH. A conserved hydrophobic patch on Vß domains revealed by TCRß chain crystal structures: Implications for pre-TCR dimerization. Front Immunol. 2011; 2:5.
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  25. Zhang Z, Tongchusak S, Mizukami Y, Kang YJ, Ioji T, Touma M, Reinhold B, Keskin DB, Reinherz EL, Sasada T. Induction of anti-tumor cytotoxic T cell responses through PLGA-nanoparticle mediated antigen delivery. Biomaterials. 2011 May; 32(14):3666-78.
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  26. Reinherz EL, Acuto O. Molecular T cell biology?--?basic and translational challenges in the twenty-first century. Front Immunol. 2011; 2:3.
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  27. Zhang GL, DeLuca DS, Keskin DB, Chitkushev L, Zlateva T, Lund O, Reinherz EL, Brusic V. MULTIPRED2: a computational system for large-scale identification of peptides predicted to bind to HLA supertypes and alleles. J Immunol Methods. 2011 Nov 30; 374(1-2):53-61.
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  28. Reinhold B, Keskin DB, Reinherz EL. Molecular Detection of Targeted Major Histocompatibility Complex I-Bound Peptides Using a Probabilistic Measure and Nanospray MS(3) on a Hybrid Quadrupole-Linear Ion Trap. Anal Chem. 2010 Nov 1; 82(21):9090-9.
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  29. Kim ST, Touma M, Takeuchi K, Sun ZY, Dave VP, Kappes DJ, Wagner G, Reinherz EL. Distinctive CD3 heterodimeric ectodomain topologies maximize antigen-triggered activation of alpha beta T cell receptors. J Immunol. 2010 Sep 1; 185(5):2951-9.
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  30. Riemer AB, Keskin DB, Zhang G, Handley M, Anderson KS, Brusic V, Reinhold B, Reinherz EL. A conserved E7-derived cytotoxic T lymphocyte epitope expressed on human papillomavirus 16-transformed HLA-A2+ epithelial cancers. J Biol Chem. 2010 Sep 17; 285(38):29608-22.
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  31. Zhang W, Choi J, Zeng W, Rogers SA, Alyea EP, Rheinwald JG, Canning CM, Brusic V, Sasada T, Reinherz EL, Ritz J, Soiffer RJ, Wu CJ. Graft-versus-leukemia antigen CML66 elicits coordinated B-cell and T-cell immunity after donor lymphocyte infusion. Clin Cancer Res. 2010 May 15; 16(10):2729-39.
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  32. Zhong W, Liu F, Dong L, Lu X, Hancock K, Reinherz EL, Katz JM, Sambhara S. Significant impact of sequence variations in the nucleoprotein on CD8 T cell-mediated cross-protection against influenza A virus infections. PLoS One. 2010; 5(5):e10583.
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  33. Xu H, Song L, Kim M, Holmes MA, Kraft Z, Sellhorn G, Reinherz EL, Stamatatos L, Strong RK. Interactions between lipids and human anti-HIV antibody 4E10 can be reduced without ablating neutralizing activity. J Virol. 2010 Jan; 84(2):1076-88.
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  34. Kim ST, Takeuchi K, Sun ZY, Touma M, Castro CE, Fahmy A, Lang MJ, Wagner G, Reinherz EL. The alphabeta T cell receptor is an anisotropic mechanosensor. J Biol Chem. 2009 Nov 6; 284(45):31028-37.
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  35. Waite AL, Schaner P, Richards N, Balci-Peynircioglu B, Masters SL, Brydges SD, Fox M, Hong A, Yilmaz E, Kastner DL, Reinherz EL, Gumucio DL. Pyrin Modulates the Intracellular Distribution of PSTPIP1. PLoS One. 2009; 4(7):e6147.
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  36. Song L, Sun ZY, Coleman KE, Zwick MB, Gach JS, Wang JH, Reinherz EL, Wagner G, Kim M. Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface. Proc Natl Acad Sci U S A. 2009 Jun 2; 106(22):9057-62.
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  37. Grandpre LE, Duke-Cohan JS, Ewald BA, Devoy C, Barouch DH, Letvin NL, Reinherz EL, Baden LR, Dolin R, Seaman MS. Immunogenicity of recombinant Modified Vaccinia Ankara following a single or multi-dose vaccine regimen in rhesus monkeys. Vaccine. 2009 Mar 4; 27(10):1549-56.
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  38. Duke-Cohan JS, Wollenick K, Witten EA, Seaman MS, Baden LR, Dolin R, Reinherz EL. The heterogeneity of human antibody responses to vaccinia virus revealed through use of focused protein arrays. Vaccine. 2009 Feb 18; 27(8):1154-65.
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  39. Lin HH, Zhang GL, Tongchusak S, Reinherz EL, Brusic V. Evaluation of MHC-II peptide binding prediction servers: applications for vaccine research. BMC Bioinformatics. 2008; 9 Suppl 12:S22.
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  40. Choi YI, Duke-Cohan JS, Ahmed WB, Handley MA, Mann F, Epstein JA, Clayton LK, Reinherz EL. PlexinD1 glycoprotein controls migration of positively selected thymocytes into the medulla. Immunity. 2008 Dec 19; 29(6):888-98.
    View in: PubMed
  41. Takeuchi K, Yang H, Ng E, Park SY, Sun ZY, Reinherz EL, Wagner G. Structural and functional evidence that Nck interaction with CD3epsilon regulates T-cell receptor activity. J Mol Biol. 2008 Jul 18; 380(4):704-16.
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  42. Garcia-Boronat M, Diez-Rivero CM, Reinherz EL, Reche PA. PVS: a web server for protein sequence variability analysis tuned to facilitate conserved epitope discovery. Nucleic Acids Res. 2008 Jul 1; 36(Web Server issue):W35-41.
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  43. Lin HH, Ray S, Tongchusak S, Reinherz EL, Brusic V. Evaluation of MHC class I peptide binding prediction servers: applications for vaccine research. BMC Immunol. 2008; 9:8.
    View in: PubMed
  44. Wang JH, Mallis RJ, Reinherz EL. Immunodominant-peptide recognition: beta testing TCRalphabeta. Immunity. 2008 Feb; 28(2):139-41.
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  45. Sun ZY, Oh KJ, Kim M, Yu J, Brusic V, Song L, Qiao Z, Wang JH, Wagner G, Reinherz EL. HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane. Immunity. 2008 Jan; 28(1):52-63.
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  46. Touma M, Antonini V, Kumar M, Osborn SL, Bobenchik AM, Keskin DB, Connolly JE, Grusby MJ, Reinherz EL, Clayton LK. Functional role for I kappa BNS in T cell cytokine regulation as revealed by targeted gene disruption. J Immunol. 2007 Aug 1; 179(3):1681-92.
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  47. Zhong W, Dixit SB, Mallis RJ, Arthanari H, Lugovskoy AA, Beveridge DL, Wagner G, Reinherz EL. CTL recognition of a protective immunodominant influenza A virus nucleoprotein epitope utilizes a highly restricted Vbeta but diverse Valpha repertoire: functional and structural implications. J Mol Biol. 2007 Sep 14; 372(2):535-48.
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  48. Aldaz-Carroll L, Xiao Y, Whitbeck JC, de Leon MP, Lou H, Kim M, Yu J, Reinherz EL, Isaacs SN, Eisenberg RJ, Cohen GH. Major neutralizing sites on vaccinia virus glycoprotein B5 are exposed differently on variola virus ortholog B6. J Virol. 2007 Aug; 81(15):8131-9.
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  49. Touma M, Sun ZY, Clayton LK, Marissen WE, Kruisbeek AM, Wagner G, Reinherz EL. Importance of the CD3gamma ectodomain terminal beta-strand and membrane proximal stalk in thymic development and receptor assembly. J Immunol. 2007 Mar 15; 178(6):3668-79.
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  50. Brusic V, Marina O, Wu CJ, Reinherz EL. Proteome informatics for cancer research: from molecules to clinic. Proteomics. 2007 Mar; 7(6):976-91.
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  51. Reche PA, Reinherz EL. Definition of MHC supertypes through clustering of MHC peptide-binding repertoires. Methods Mol Biol. 2007; 409:163-73.
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  52. Reche PA, Reinherz EL. Prediction of peptide-MHC binding using profiles. Methods Mol Biol. 2007; 409:185-200.
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  53. Kim M, Qiao Z, Yu J, Montefiori D, Reinherz EL. Immunogenicity of recombinant human immunodeficiency virus type 1-like particles expressing gp41 derivatives in a pre-fusion state. Vaccine. 2007 Jun 28; 25(27):5102-14.
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  54. Touma M, Chang HC, Sasada T, Handley M, Clayton LK, Reinherz EL. The TCR C beta FG loop regulates alpha beta T cell development. J Immunol. 2006 Jun 1; 176(11):6812-23.
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  55. Reche PA, Keskin DB, Hussey RE, Ancuta P, Gabuzda D, Reinherz EL. Elicitation from virus-naive individuals of cytotoxic T lymphocytes directed against conserved HIV-1 epitopes. Med Immunol. 2006; 5:1.
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  56. Yang H, Reinherz EL. CD2BP1 modulates CD2-dependent T cell activation via linkage to protein tyrosine phosphatase (PTP)-PEST. J Immunol. 2006 May 15; 176(10):5898-907.
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  57. Bhasin M, Reinherz EL, Reche PA. Recognition and classification of histones using support vector machine. J Comput Biol. 2006 Jan-Feb; 13(1):102-12.
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  58. Chang HC, Tan K, Ouyang J, Parisini E, Liu JH, Le Y, Wang X, Reinherz EL, Wang JH. Structural and mutational analyses of a CD8alphabeta heterodimer and comparison with the CD8alphaalpha homodimer. Immunity. 2005 Dec; 23(6):661-71.
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  59. Zhong W, Reinherz EL. CD8 alpha alpha homodimer expression and role in CD8 T cell memory generation during influenza virus A infection in mice. Eur J Immunol. 2005 Nov; 35(11):3103-10.
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  60. Bhasin M, Zhang H, Reinherz EL, Reche PA. Prediction of methylated CpGs in DNA sequences using a support vector machine. FEBS Lett. 2005 Aug 15; 579(20):4302-8.
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  61. Reche PA, Reinherz EL. PEPVAC: a web server for multi-epitope vaccine development based on the prediction of supertypic MHC ligands. Nucleic Acids Res. 2005 Jul 1; 33(Web Server issue):W138-42.
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  62. Qiao ZS, Kim M, Reinhold B, Montefiori D, Wang JH, Reinherz EL. Design, expression, and immunogenicity of a soluble HIV trimeric envelope fragment adopting a prefusion gp41 configuration. J Biol Chem. 2005 Jun 17; 280(24):23138-46.
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  63. Attinger A, Devine L, Wang-Zhu Y, Martin D, Wang JH, Reinherz EL, Kronenberg M, Cheroutre H, Kavathas P. Molecular basis for the high affinity interaction between the thymic leukemia antigen and the CD8alphaalpha molecule. J Immunol. 2005 Mar 15; 174(6):3501-7.
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  64. Yang H, Kim SK, Kim M, Reche PA, Morehead TJ, Damon IK, Welsh RM, Reinherz EL. Antiviral chemotherapy facilitates control of poxvirus infections through inhibition of cellular signal transduction. J Clin Invest. 2005 Feb; 115(2):379-87.
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  65. Reche PA, Zhang H, Glutting JP, Reinherz EL. EPIMHC: a curated database of MHC-binding peptides for customized computational vaccinology. Bioinformatics. 2005 May 1; 21(9):2140-1.
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  66. Kim M, Qiao ZS, Montefiori DC, Haynes BF, Reinherz EL, Liao HX. Comparison of HIV Type 1 ADA gp120 monomers versus gp140 trimers as immunogens for the induction of neutralizing antibodies. AIDS Res Hum Retroviruses. 2005 Jan; 21(1):58-67.
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  67. Fridkis-Hareli M, Reinherz EL. New approaches to eliciting protective immunity through T cell repertoire manipulation: the concept of thymic vaccination. Med Immunol. 2004 Dec 8; 3(1):2.
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  68. Meijers R, Lai CC, Yang Y, Liu JH, Zhong W, Wang JH, Reinherz EL. Crystal structures of murine MHC Class I H-2 D(b) and K(b) molecules in complex with CTL epitopes from influenza A virus: implications for TCR repertoire selection and immunodominance. J Mol Biol. 2005 Feb 4; 345(5):1099-110.
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  69. Sun ZY, Kim ST, Kim IC, Fahmy A, Reinherz EL, Wagner G. Solution structure of the CD3epsilondelta ectodomain and comparison with CD3epsilongamma as a basis for modeling T cell receptor topology and signaling. Proc Natl Acad Sci U S A. 2004 Nov 30; 101(48):16867-72.
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  70. Zhong W, Reinherz EL. In vivo selection of a TCR Vbeta repertoire directed against an immunodominant influenza virus CTL epitope. Int Immunol. 2004 Nov; 16(11):1549-59.
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  71. Reche PA, Glutting JP, Zhang H, Reinherz EL. Enhancement to the RANKPEP resource for the prediction of peptide binding to MHC molecules using profiles. Immunogenetics. 2004 Sep; 56(6):405-19.
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  72. Fridkis-Hareli M, Reche PA, Reinherz EL. Peptide variants of viral CTL epitopes mediate positive selection and emigration of Ag-specific thymocytes in vivo. J Immunol. 2004 Jul 15; 173(2):1140-50.
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  73. Chen B, Cheng Y, Calder L, Harrison SC, Reinherz EL, Skehel JJ, Wiley DC. A chimeric protein of simian immunodeficiency virus envelope glycoprotein gp140 and Escherichia coli aspartate transcarbamoylase. J Virol. 2004 May; 78(9):4508-16.
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  74. Kim M, Yang H, Kim SK, Reche PA, Tirabassi RS, Hussey RE, Chishti Y, Rheinwald JG, Morehead TJ, Zech T, Damon IK, Welsh RM, Reinherz EL. Biochemical and functional analysis of smallpox growth factor (SPGF) and anti-SPGF monoclonal antibodies. J Biol Chem. 2004 Jun 11; 279(24):25838-48.
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  75. Dogan I, Dorgham K, Chang HC, Parizot C, Lemaître F, Ferradini L, Reinherz EL, Debré P, Gorochov G. Phage-displayed libraries of peptide/major histocompatibility complexes. Eur J Immunol. 2004 Feb; 34(2):598-607.
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  76. Schmitz I, Clayton LK, Reinherz EL. Gene expression analysis of thymocyte selection in vivo. Int Immunol. 2003 Oct; 15(10):1237-48.
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  77. Freund C, Kühne R, Park S, Thiemke K, Reinherz EL, Wagner G. Structural investigations of a GYF domain covalently linked to a proline-rich peptide. J Biomol NMR. 2003 Oct; 27(2):143-9.
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  78. Zhong W, Reche PA, Lai CC, Reinhold B, Reinherz EL. Genome-wide characterization of a viral cytotoxic T lymphocyte epitope repertoire. J Biol Chem. 2003 Nov 14; 278(46):45135-44.
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  79. Reche PA, Reinherz EL. Sequence variability analysis of human class I and class II MHC molecules: functional and structural correlates of amino acid polymorphisms. J Mol Biol. 2003 Aug 15; 331(3):623-41.
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  80. Crawford K, Stark A, Kitchens B, Sternheim K, Pantazopoulos V, Triantafellow E, Wang Z, Vasir B, Larsen CE, Gabuzda D, Reinherz E, Alper CA. CD2 engagement induces dendritic cell activation: implications for immune surveillance and T-cell activation. Blood. 2003 Sep 1; 102(5):1745-52.
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  81. Tibaldi EV, Reinherz EL. CD2BP3, CIN85 and the structurally related adaptor protein CMS bind to the same CD2 cytoplasmic segment, but elicit divergent functional activities. Int Immunol. 2003 Mar; 15(3):313-29.
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  82. Liu Y, Xiong Y, Naidenko OV, Liu JH, Zhang R, Joachimiak A, Kronenberg M, Cheroutre H, Reinherz EL, Wang JH. The crystal structure of a TL/CD8alphaalpha complex at 2.1 A resolution: implications for modulation of T cell activation and memory. Immunity. 2003 Feb; 18(2):205-15.
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  83. Sasada T, Yang Y, Lai CC, Touma M, Clayton LK, Liu JH, Parisini E, Wang JH, Reinherz EL. Disparate peptide-dependent thymic selection outcomes in beta2M-deficient mice versus TAP-1-deficient mice: implications for repertoire formation. Eur J Immunol. 2003 Feb; 33(2):368-80.
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  84. Moody AM, North SJ, Reinhold B, Van Dyken SJ, Rogers ME, Panico M, Dell A, Morris HR, Marth JD, Reinherz EL. Sialic acid capping of CD8beta core 1-O-glycans controls thymocyte-major histocompatibility complex class I interaction. J Biol Chem. 2003 Feb 28; 278(9):7240-6.
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  85. Freund C, Kühne R, Yang H, Park S, Reinherz EL, Wagner G. Dynamic interaction of CD2 with the GYF and the SH3 domain of compartmentalized effector molecules. EMBO J. 2002 Nov 15; 21(22):5985-95.
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  86. Weber DA, Attinger A, Kemball CC, Wigal JL, Pohl J, Xiong Y, Reinherz EL, Cheroutre H, Kronenberg M, Jensen PE. Peptide-independent folding and CD8 alpha alpha binding by the nonclassical class I molecule, thymic leukemia antigen. J Immunol. 2002 Nov 15; 169(10):5708-14.
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  87. Reche PA, Glutting JP, Reinherz EL. Prediction of MHC class I binding peptides using profile motifs. Hum Immunol. 2002 Sep; 63(9):701-9.
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  88. Sasada T, Touma M, Chang HC, Clayton LK, Wang JH, Reinherz EL. Involvement of the TCR Cbeta FG loop in thymic selection and T cell function. J Exp Med. 2002 Jun 3; 195(11):1419-31.
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  89. Tibaldi EV, Salgia R, Reinherz EL. CD2 molecules redistribute to the uropod during T cell scanning: implications for cellular activation and immune surveillance. Proc Natl Acad Sci U S A. 2002 May 28; 99(11):7582-7.
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  90. Wang JH, Reinherz EL. Structural basis of T cell recognition of peptides bound to MHC molecules. Mol Immunol. 2002 May; 38(14):1039-49.
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  91. Fiorini E, Schmitz I, Marissen WE, Osborn SL, Touma M, Sasada T, Reche PA, Tibaldi EV, Hussey RE, Kruisbeek AM, Reinherz EL, Clayton LK. Peptide-induced negative selection of thymocytes activates transcription of an NF-kappa B inhibitor. Mol Cell. 2002 Mar; 9(3):637-48.
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  92. Sasada T, Yang H, Reinherz EL. CD2 facilitates differentiation of CD4 Th cells without affecting Th1/Th2 polarization. J Immunol. 2002 Feb 1; 168(3):1113-22.
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  93. Leishman AJ, Naidenko OV, Attinger A, Koning F, Lena CJ, Xiong Y, Chang HC, Reinherz E, Kronenberg M, Cheroutre H. T cell responses modulated through interaction between CD8alphaalpha and the nonclassical MHC class I molecule, TL. Science. 2001 Nov 30; 294(5548):1936-9.
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  94. Moody AM, Chui D, Reche PA, Priatel JJ, Marth JD, Reinherz EL. Developmentally regulated glycosylation of the CD8alphabeta coreceptor stalk modulates ligand binding. Cell. 2001 Nov 16; 107(4):501-12.
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  95. Suzue K, Reinherz EL, Koyasu S. Critical role of NK but not NKT cells in acute rejection of parental bone marrow cells in F1 hybrid mice. Eur J Immunol. 2001 Nov; 31(11):3147-52.
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  96. Sasada T, Ghendler Y, Neveu JM, Lane WS, Reinherz EL. A naturally processed mitochondrial self-peptide in complex with thymic MHC molecules functions as a selecting ligand for a viral-specific T cell receptor. J Exp Med. 2001 Oct 1; 194(7):883-92.
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  97. Kim M, Sun ZY, Byron O, Campbell G, Wagner G, Wang J, Reinherz EL. Molecular dissection of the CD2-CD58 counter-receptor interface identifies CD2 Tyr86 and CD58 Lys34 residues as the functional "hot spot". J Mol Biol. 2001 Sep 28; 312(4):711-20.
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  98. Kim M, Chen B, Hussey RE, Chishti Y, Montefiori D, Hoxie JA, Byron O, Campbell G, Harrison SC, Reinherz EL. The stoichiometry of trimeric SIV glycoprotein interaction with CD4 differs from that of anti-envelope antibody Fab fragments. J Biol Chem. 2001 Nov 16; 276(46):42667-76.
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  99. Wang JH, Meijers R, Xiong Y, Liu JH, Sakihama T, Zhang R, Joachimiak A, Reinherz EL. Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule. Proc Natl Acad Sci U S A. 2001 Sep 11; 98(19):10799-804.
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  100. Moody AM, Xiong Y, Chang HC, Reinherz EL. The CD8alphabeta co-receptor on double-positive thymocytes binds with differing affinities to the products of distinct class I MHC loci. Eur J Immunol. 2001 Sep; 31(9):2791-9.
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  101. Zhang CW, Chishti Y, Hussey RE, Reinherz EL. Expression, purification, and characterization of recombinant HIV gp140. The gp41 ectodomain of HIV or simian immunodeficiency virus is sufficient to maintain the retroviral envelope glycoprotein as a trimer. J Biol Chem. 2001 Oct 26; 276(43):39577-85.
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  102. Leker RR, Teichner A, Ovadia H, Keshet E, Reinherz E, Ben-Hur T. Expression of endothelial nitric oxide synthase in the ischemic penumbra: relationship to expression of neuronal nitric oxide synthase and vascular endothelial growth factor. Brain Res. 2001 Aug 3; 909(1-2):1-7.
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  103. Sun ZJ, Kim KS, Wagner G, Reinherz EL. Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer. Cell. 2001 Jun 29; 105(7):913-23.
    View in: PubMed
  104. Yang H, Reinherz EL. Dynamic recruitment of human CD2 into lipid rafts. Linkage to T cell signal transduction. J Biol Chem. 2001 Jun 1; 276(22):18775-85.
    View in: PubMed
  105. Sasada T, Reinherz EL. A critical role for CD2 in both thymic selection events and mature T cell function. J Immunol. 2001 Feb 15; 166(4):2394-403.
    View in: PubMed
  106. Xiong Y, Kern P, Chang H, Reinherz E. T Cell Receptor Binding to a pMHCII Ligand Is Kinetically Distinct from and Independent of CD4. J Biol Chem. 2001 Feb 23; 276(8):5659-67.
    View in: PubMed
  107. Wang J, Reinherz EL. Structural basis of cell-cell interactions in the immune system. Curr Opin Struct Biol. 2000 Dec; 10(6):656-61.
    View in: PubMed
  108. Fukai I, Hussey RE, Sunder-Plassmann R, Reinherz EL. A critical role for p59(fyn) in CD2-based signal transduction. Eur J Immunol. 2000 Dec; 30(12):3507-15.
    View in: PubMed
  109. Chen B, Zhou G, Kim M, Chishti Y, Hussey RE, Ely B, Skehel JJ, Reinherz EL, Harrison SC, Wiley DC. Expression, purification, and characterization of gp160e, the soluble, trimeric ectodomain of the simian immunodeficiency virus envelope glycoprotein, gp160. J Biol Chem. 2000 Nov 10; 275(45):34946-53.
    View in: PubMed
  110. Kim KS, Sun ZY, Wagner G, Reinherz EL. Heterodimeric CD3epsilongamma extracellular domain fragments: production, purification and structural analysis. J Mol Biol. 2000 Sep 29; 302(4):899-916.
    View in: PubMed
  111. Hanada T, Lin L, Tibaldi EV, Reinherz EL, Chishti AH. GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes. J Biol Chem. 2000 Sep 15; 275(37):28774-84.
    View in: PubMed
  112. Tsuchihashi N, Matsuda S, Reinherz EL, Koyasu S. Two YxxL segments of a single immunoreceptor tyrosine-based activation motif in the CD3zeta molecule differentially activate calcium mobilization and mitogen-activated protein kinase family pathways. Eur J Immunol. 2000 Jun; 30(6):1785-93.
    View in: PubMed
  113. Sasada T, Ghendler Y, Wang JH, Reinherz EL. Thymic selection is influenced by subtle structural variation involving the p4 residue of an MHC class I-bound peptide. Eur J Immunol. 2000 May; 30(5):1281-9.
    View in: PubMed
  114. Sakihama T, Hunsicker ME, Hussey RE, Reinherz EL. Human CD4 residue Phe 43 is critical for repertoire development and maturation of MHC class II restricted CD4 single-positive T lineage cells in vivo. Eur J Immunol. 2000 Jan; 30(1):279-90.
    View in: PubMed
  115. Reinherz EL, Tan K, Tang L, Kern P, Liu J, Xiong Y, Hussey RE, Smolyar A, Hare B, Zhang R, Joachimiak A, Chang HC, Wagner G, Wang J. The crystal structure of a T cell receptor in complex with peptide and MHC class II. Science. 1999 Dec 3; 286(5446):1913-21.
    View in: PubMed
  116. Crawford K, Gabuzda D, Pantazopoulos V, Xu J, Clement C, Reinherz E, Alper CA. Circulating CD2+ monocytes are dendritic cells. J Immunol. 1999 Dec 1; 163(11):5920-8.
    View in: PubMed
  117. Kern P, Hussey RE, Spoerl R, Reinherz EL, Chang HC. Expression, purification, and functional analysis of murine ectodomain fragments of CD8alphaalpha and CD8alphabeta dimers. J Biol Chem. 1999 Sep 17; 274(38):27237-43.
    View in: PubMed
  118. Freund C, Dötsch V, Nishizawa K, Reinherz EL, Wagner G. The GYF domain is a novel structural fold that is involved in lymphoid signaling through proline-rich sequences. Nat Struct Biol. 1999 Jul; 6(7):656-60.
    View in: PubMed
  119. Wang JH, Smolyar A, Tan K, Liu JH, Kim M, Sun ZY, Wagner G, Reinherz EL. Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors. Cell. 1999 Jun 11; 97(6):791-803.
    View in: PubMed
  120. Sun ZY, Dötsch V, Kim M, Li J, Reinherz EL, Wagner G. Functional glycan-free adhesion domain of human cell surface receptor CD58: design, production and NMR studies. EMBO J. 1999 Jun 1; 18(11):2941-9.
    View in: PubMed
  121. Hare BJ, Wyss DF, Osburne MS, Kern PS, Reinherz EL, Wagner G. Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor. Nat Struct Biol. 1999 Jun; 6(6):574-81.
    View in: PubMed
  122. Li J, Nishizawa K, An W, Hussey RE, Lialios FE, Salgia R, Sunder-Plassmann R, Reinherz EL. A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion. EMBO J. 1998 Dec 15; 17(24):7320-36.
    View in: PubMed
  123. Nishizawa K, Freund C, Li J, Wagner G, Reinherz EL. Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation. Proc Natl Acad Sci U S A. 1998 Dec 8; 95(25):14897-902.
    View in: PubMed
  124. Kern PS, Teng MK, Smolyar A, Liu JH, Liu J, Hussey RE, Spoerl R, Chang HC, Reinherz EL, Wang JH. Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2Kb. Immunity. 1998 Oct; 9(4):519-30.
    View in: PubMed
  125. Sunder-Plassmann R, Reinherz EL. A p56lck-independent pathway of CD2 signaling involves Jun kinase. J Biol Chem. 1998 Sep 11; 273(37):24249-57.
    View in: PubMed
  126. Ghendler Y, Teng MK, Liu JH, Witte T, Liu J, Kim KS, Kern P, Chang HC, Wang JH, Reinherz EL. Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligands. Proc Natl Acad Sci U S A. 1998 Aug 18; 95(17):10061-6.
    View in: PubMed
  127. Ghendler Y, Smolyar A, Chang HC, Reinherz EL. One of the CD3epsilon subunits within a T cell receptor complex lies in close proximity to the Cbeta FG loop. J Exp Med. 1998 May 4; 187(9):1529-36.
    View in: PubMed
  128. Teng MK, Smolyar A, Tse AG, Liu JH, Liu J, Hussey RE, Nathenson SG, Chang HC, Reinherz EL, Wang JH. Identification of a common docking topology with substantial variation among different TCR-peptide-MHC complexes. Curr Biol. 1998 Mar 26; 8(7):409-12.
    View in: PubMed
  129. Wang J, Lim K, Smolyar A, Teng M, Liu J, Tse AG, Liu J, Hussey RE, Chishti Y, Thomson CT, Sweet RM, Nathenson SG, Chang HC, Sacchettini JC, Reinherz EL. Atomic structure of an alphabeta T cell receptor (TCR) heterodimer in complex with an anti-TCR fab fragment derived from a mitogenic antibody. EMBO J. 1998 Jan 2; 17(1):10-26.
    View in: PubMed
  130. Koyasu S, Clayton LK, Lerner A, Heiken H, Parkes A, Reinherz EL. Pre-TCR signaling components trigger transcriptional activation of a rearranged TCR alpha gene locus and silencing of the pre-TCR alpha locus: implications for intrathymic differentiation. Int Immunol. 1997 Oct; 9(10):1475-80.
    View in: PubMed
  131. Ghendler Y, Hussey RE, Witte T, Mizoguchi E, Clayton LK, Bhan AK, Koyasu S, Chang HC, Reinherz EL. Double-positive T cell receptor(high) thymocytes are resistant to peptide/major histocompatibility complex ligand-induced negative selection. Eur J Immunol. 1997 Sep; 27(9):2279-89.
    View in: PubMed
  132. Chang HC, Smolyar A, Spoerl R, Witte T, Yao Y, Goyarts EC, Nathenson SG, Reinherz EL. Topology of T cell receptor-peptide/class I MHC interaction defined by charge reversal complementation and functional analysis. J Mol Biol. 1997 Aug 15; 271(2):278-93.
    View in: PubMed
  133. Golden A, Khandekar SS, Osburne MS, Kawasaki E, Reinherz EL, Grossman TH. High-level production of a secreted, heterodimeric alpha beta murine T-cell receptor in Escherichia coli. J Immunol Methods. 1997 Aug 7; 206(1-2):163-9.
    View in: PubMed
  134. Sunder-Plassmann R, Lialios F, Madsen M, Koyasu S, Reinherz EL. Functional analysis of immunoreceptor tyrosine-based activation motif (ITAM)-mediated signal transduction: the two YxxL segments within a single CD3zeta-ITAM are functionally distinct. Eur J Immunol. 1997 Aug; 27(8):2001-9.
    View in: PubMed
  135. Clayton LK, Ghendler Y, Mizoguchi E, Patch RJ, Ocain TD, Orth K, Bhan AK, Dixit VM, Reinherz EL. T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection. EMBO J. 1997 May 1; 16(9):2282-93.
    View in: PubMed
  136. Witte T, Smolyar A, Spoerl R, Goyarts EC, Nathenson SG, Reinherz EL, Chang HC. Major histocompatibility complex recognition by immune receptors: differences among T cell receptor versus antibody interactions with the VSV8/H-2Kb complex. Eur J Immunol. 1997 Jan; 27(1):227-33.
    View in: PubMed
  137. Liu J, Tse AG, Chang HC, Liu Jh, Wang J, Hussey RE, Chishti Y, Rheinhold B, Spoerl R, Nathenson SG, Sacchettini JC, Reinherz EL. Crystallization of a deglycosylated T cell receptor (TCR) complexed with an anti-TCR Fab fragment. J Biol Chem. 1996 Dec 27; 271(52):33639-46.
    View in: PubMed
  138. King PD, Sadra A, Han A, Liu XR, Sunder-Plassmann R, Reinherz EL, Dupont B. CD2 signaling in T cells involves tyrosine phosphorylation and activation of the Tec family kinase, EMT/ITK/TSK. Int Immunol. 1996 Nov; 8(11):1707-14.
    View in: PubMed
  139. Lerner A, Clayton LK, Mizoguchi E, Ghendler Y, van Ewijk W, Koyasu S, Bhan AK, Reinherz EL. Cross-linking of T-cell receptors on double-positive thymocytes induces a cytokine-mediated stromal activation process linked to cell death. EMBO J. 1996 Nov 1; 15(21):5876-87.
    View in: PubMed
  140. Li J, Smolyar A, Sunder-Plassmann R, Reinherz EL. Ligand-induced conformational change within the CD2 ectodomain accompanies receptor clustering: implication for molecular lattice formation. J Mol Biol. 1996 Oct 25; 263(2):209-26.
    View in: PubMed
  141. Gollob JA, Li J, Kawasaki H, Daley JF, Groves C, Reinherz EL, Ritz J. Molecular interaction between CD58 and CD2 counter-receptors mediates the ability of monocytes to augment T cell activation by IL-12. J Immunol. 1996 Sep 1; 157(5):1886-93.
    View in: PubMed
  142. Reinherz EL, Li J, Smoylar A, Wyss DF, Knoppers MH, Willis KJ, Arulanandam AR, Choi JS, Wagner G. Response: CD2: An Exception to the Immunologlobulin Superfamily Concept? Science. 1996 Aug 30; 273(5279):1242.
    View in: PubMed
  143. Heiken H, Schulz RJ, Ravetch JV, Reinherz EL, Koyasu S. T lymphocyte development in the absence of Fc epsilon receptor I gamma subunit: analysis of thymic-dependent and independent alpha beta and gamma delta pathways. Eur J Immunol. 1996 Aug; 26(8):1935-43.
    View in: PubMed
  144. Sakihama T, Smolyar A, Reinherz EL. Molecular recognition of antigen involves lattice formation between CD4, MHC class II and TCR molecules. Immunol Today. 1995 Dec; 16(12):581-7.
    View in: PubMed
  145. Gollob JA, Li J, Reinherz EL, Ritz J. CD2 regulates responsiveness of activated T cells to interleukin 12. J Exp Med. 1995 Sep 1; 182(3):721-31.
    View in: PubMed
  146. Wyss DF, Choi JS, Li J, Knoppers MH, Willis KJ, Arulanandam AR, Smolyar A, Reinherz EL, Wagner G. Conformation and function of the N-linked glycan in the adhesion domain of human CD2. Science. 1995 Sep 1; 269(5228):1273-8.
    View in: PubMed
  147. Sakihama T, Smolyar A, Reinherz EL. Oligomerization of CD4 is required for stable binding to class II major histocompatibility complex proteins but not for interaction with human immunodeficiency virus gp120. Proc Natl Acad Sci U S A. 1995 Jul 3; 92(14):6444-8.
    View in: PubMed
  148. Kalled SL, Siva N, Stein H, Reinherz EL. The distribution of CD10 (NEP 24.11, CALLA) in humans and mice is similar in non-lymphoid organs but differs within the hematopoietic system: absence on murine T and B lymphoid progenitors. Eur J Immunol. 1995 Mar; 25(3):677-87.
    View in: PubMed
  149. Arulanandam AR, Kister A, McGregor MJ, Wyss DF, Wagner G, Reinherz EL. Interaction between human CD2 and CD58 involves the major beta sheet surface of each of their respective adhesion domains. J Exp Med. 1994 Nov 1; 180(5):1861-71.
    View in: PubMed
  150. Koyasu S, Tse AG, Moingeon P, Hussey RE, Mildonian A, Hannisian J, Clayton LK, Reinherz EL. Delineation of a T-cell activation motif required for binding of protein tyrosine kinases containing tandem SH2 domains. Proc Natl Acad Sci U S A. 1994 Jul 5; 91(14):6693-7.
    View in: PubMed
  151. Humphreys T, Reinherz EL. Invertebrate immune recognition, natural immunity and the evolution of positive selection. Immunol Today. 1994 Jul; 15(7):316-20.
    View in: PubMed
  152. Koyasu S, Hussey RE, Clayton LK, Lerner A, Pedersen R, Delany-Heiken P, Chau F, Reinherz EL. Targeted disruption within the CD3 zeta/eta/phi/Oct-1 locus in mouse. EMBO J. 1994 Feb 15; 13(4):784-97.
    View in: PubMed
  153. Arulanandam AR, Withka JM, Wyss DF, Wagner G, Kister A, Pallai P, Recny MA, Reinherz EL. The CD58 (LFA-3) binding site is a localized and highly charged surface area on the AGFCC'C" face of the human CD2 adhesion domain. Proc Natl Acad Sci U S A. 1993 Dec 15; 90(24):11613-7.
    View in: PubMed
  154. Withka JM, Wyss DF, Wagner G, Arulanandam AR, Reinherz EL, Recny MA. Structure of the glycosylated adhesion domain of human T lymphocyte glycoprotein CD2. Structure. 1993 Sep 15; 1(1):69-81.
    View in: PubMed
  155. Lerner A, D'Adamio L, Diener AC, Clayton LK, Reinherz EL. CD3 zeta/eta/theta locus is colinear with and transcribed antisense to the gene encoding the transcription factor Oct-1. J Immunol. 1993 Sep 15; 151(6):3152-62.
    View in: PubMed
  156. Moingeon P, Rodewald HR, McConkey D, Mildonian A, Awad K, Reinherz EL. Generation of natural killer cells from both Fc gamma RII/III+ and Fc gamma RII/III- murine fetal liver progenitors. Blood. 1993 Sep 1; 82(5):1453-62.
    View in: PubMed
  157. Moebius U, Pallai P, Harrison SC, Reinherz EL. Delineation of an extended surface contact area on human CD4 involved in class II major histocompatibility complex binding. Proc Natl Acad Sci U S A. 1993 Sep 1; 90(17):8259-63.
    View in: PubMed
  158. Salles G, Rodewald HR, Chin BS, Reinherz EL, Shipp MA. Inhibition of CD10/neutral endopeptidase 24.11 promotes B-cell reconstitution and maturation in vivo. Proc Natl Acad Sci U S A. 1993 Aug 15; 90(16):7618-22.
    View in: PubMed
  159. Arulanandam AR, Moingeon P, Concino MF, Recny MA, Kato K, Yagita H, Koyasu S, Reinherz EL. A soluble multimeric recombinant CD2 protein identifies CD48 as a low affinity ligand for human CD2: divergence of CD2 ligands during the evolution of humans and mice. J Exp Med. 1993 May 1; 177(5):1439-50.
    View in: PubMed
  160. Rodewald HR, Awad K, Moingeon P, D'Adamio L, Rabinowitz D, Shinkai Y, Alt FW, Reinherz EL. Fc gamma RII/III and CD2 expression mark distinct subpopulations of immature CD4-CD8- murine thymocytes: in vivo developmental kinetics and T cell receptor beta chain rearrangement status. J Exp Med. 1993 Apr 1; 177(4):1079-92.
    View in: PubMed
  161. D'Adamio L, Awad KM, Reinherz EL. Thymic and peripheral apoptosis of antigen-specific T cells might cooperate in establishing self tolerance. Eur J Immunol. 1993 Mar; 23(3):747-53.
    View in: PubMed
  162. Shinkai Y, Koyasu S, Nakayama K, Murphy KM, Loh DY, Reinherz EL, Alt FW. Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes. Science. 1993 Feb 5; 259(5096):822-5.
    View in: PubMed
  163. Kister A, Muchnik I, Bouzida D, Reinherz EL, Smith T. Efficient pattern comparative method for selecting functionally important motifs in protein sequences: application to zinc enzymes. Biosystems. 1993; 30(1-3):233-40.
    View in: PubMed
  164. Clayton LK, Diener AC, Lerner A, Tse AG, Koyasu S, Reinherz EL. Differential regulation of T-cell receptor processing and surface expression affected by CD3 theta, an alternatively spliced product of the CD3 zeta/eta gene locus. J Biol Chem. 1992 Dec 25; 267(36):26023-30.
    View in: PubMed
  165. Moebius U, Clayton LK, Abraham S, Diener A, Yunis JJ, Harrison SC, Reinherz EL. Human immunodeficiency virus gp120 binding C'C" ridge of CD4 domain 1 is also involved in interaction with class II major histocompatibility complex molecules. Proc Natl Acad Sci U S A. 1992 Dec 15; 89(24):12008-12.
    View in: PubMed
  166. D'Adamio L, Clayton LK, Awad KM, Reinherz EL. Negative selection of thymocytes. A novel polymerase chain reaction-based molecular analysis detects requirements for macromolecular synthesis. J Immunol. 1992 Dec 1; 149(11):3550-3.
    View in: PubMed
  167. Ganju RK, Smiley ST, Bajorath J, Novotny J, Reinherz EL. Similarity between fluorescein-specific T-cell receptor and antibody in chemical details of antigen recognition. Proc Natl Acad Sci U S A. 1992 Dec 1; 89(23):11552-6.
    View in: PubMed
  168. Salles G, Chen CY, Reinherz EL, Shipp MA. CD10/NEP is expressed on Thy-1low B220+ murine B-cell progenitors and functions to regulate stromal cell-dependent lymphopoiesis. Blood. 1992 Oct 15; 80(8):2021-9.
    View in: PubMed
  169. Moebius U, Clayton LK, Abraham S, Harrison SC, Reinherz EL. The human immunodeficiency virus gp120 binding site on CD4: delineation by quantitative equilibrium and kinetic binding studies of mutants in conjunction with a high-resolution CD4 atomic structure. J Exp Med. 1992 Aug 1; 176(2):507-17.
    View in: PubMed
  170. Moingeon P, Lucich JL, Reinherz EL. Characterization of Fc epsilon RI gamma in human natural killer cells. Int Immunol. 1992 Aug; 4(8):955-8.
    View in: PubMed
  171. Lerner A, Diener AC, Reinherz EL, Clayton LK. Human genomic sequences corresponding to murine CD3 eta-related transcripts: lack of conservation or expression of homologous human products. Eur J Immunol. 1992 Aug; 22(8):2135-40.
    View in: PubMed
  172. Howard FD, Moingeon P, Moebius U, McConkey DJ, Yandava B, Gennert TE, Reinherz EL. The CD3 zeta cytoplasmic domain mediates CD2-induced T cell activation. J Exp Med. 1992 Jul 1; 176(1):139-45.
    View in: PubMed
  173. Chen CY, Salles G, Seldin MF, Kister AE, Reinherz EL, Shipp MA. Murine common acute lymphoblastic leukemia antigen (CD10 neutral endopeptidase 24.11). Molecular characterization, chromosomal localization, and modeling of the active site. J Immunol. 1992 May 1; 148(9):2817-25.
    View in: PubMed
  174. Rodewald HR, Moingeon P, Lucich JL, Dosiou C, Lopez P, Reinherz EL. A population of early fetal thymocytes expressing Fc gamma RII/III contains precursors of T lymphocytes and natural killer cells. Cell. 1992 Apr 3; 69(1):139-50.
    View in: PubMed
  175. Moingeon P, Lucich JL, McConkey DJ, Letourneur F, Malissen B, Kochan J, Chang HC, Rodewald HR, Reinherz EL. CD3 zeta dependence of the CD2 pathway of activation in T lymphocytes and natural killer cells. Proc Natl Acad Sci U S A. 1992 Feb 15; 89(4):1492-6.
    View in: PubMed
  176. Koyasu S, McConkey DJ, Clayton LK, Abraham S, Yandava B, Katagiri T, Moingeon P, Yamamoto T, Reinherz EL. Phosphorylation of multiple CD3 zeta tyrosine residues leads to formation of pp21 in vitro and in vivo. Structural changes upon T cell receptor stimulation. J Biol Chem. 1992 Feb 15; 267(5):3375-81.
    View in: PubMed
  177. Koyasu S, D'Adamio L, Arulanandam AR, Abraham S, Clayton LK, Reinherz EL. T cell receptor complexes containing Fc epsilon RI gamma homodimers in lieu of CD3 zeta and CD3 eta components: a novel isoform expressed on large granular lymphocytes. J Exp Med. 1992 Jan 1; 175(1):203-9.
    View in: PubMed
  178. Harrison SC, Wang J, Yan Y, Garrett T, Liu J, Moebius U, Reinherz E. Structure and interactions of CD4. Cold Spring Harb Symp Quant Biol. 1992; 57:541-8.
    View in: PubMed
  179. Clayton LK, Lerner A, Diener AC, Hussey RE, Koyasu S, Reinherz EL. T-cell-receptor isoforms. Int J Cancer Suppl. 1992; 7:1-5.
    View in: PubMed
  180. Shipp MA, Tarr GE, Chen CY, Switzer SN, Hersh LB, Stein H, Sunday ME, Reinherz EL. CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung. Proc Natl Acad Sci U S A. 1991 Dec 1; 88(23):10662-6.
    View in: PubMed
  181. Novotny J, Ganju RK, Smiley ST, Hussey RE, Luther MA, Recny MA, Siliciano RF, Reinherz EL. A soluble, single-chain T-cell receptor fragment endowed with antigen-combining properties. Proc Natl Acad Sci U S A. 1991 Oct 1; 88(19):8646-50.
    View in: PubMed
  182. Shipp MA, Stefano GB, Switzer SN, Griffin JD, Reinherz EL. CD10 (CALLA)/neutral endopeptidase 24.11 modulates inflammatory peptide-induced changes in neutrophil morphology, migration, and adhesion proteins and is itself regulated by neutrophil activation. Blood. 1991 Oct 1; 78(7):1834-41.
    View in: PubMed
  183. Rodewald HR, Arulanandam AR, Koyasu S, Reinherz EL. The high affinity Fc epsilon receptor gamma subunit (Fc epsilon RI gamma) facilitates T cell receptor expression and antigen/major histocompatibility complex-driven signaling in the absence of CD3 zeta and CD3 eta. J Biol Chem. 1991 Aug 25; 266(24):15974-8.
    View in: PubMed
  184. Brown DA, Nelson FB, Reinherz EL, Diamond DJ. The human interferon-gamma gene contains an inducible promoter that can be transactivated by tax I and II. Eur J Immunol. 1991 Aug; 21(8):1879-85.
    View in: PubMed
  185. Diamond DJ, Szalay P, Symer D, Hao P, Shin HS, Dintzis RZ, Dintzis HM, Reinherz EL, Siliciano RF. Major histocompatibility complex independent T cell receptor-antigen interaction: functional analysis using fluorescein derivatives. J Exp Med. 1991 Jul 1; 174(1):229-41.
    View in: PubMed
  186. Clayton LK, D'Adamio L, Howard FD, Sieh M, Hussey RE, Koyasu S, Reinherz EL. CD3 eta and CD3 zeta are alternatively spliced products of a common genetic locus and are transcriptionally and/or post-transcriptionally regulated during T-cell development. Proc Natl Acad Sci U S A. 1991 Jun 15; 88(12):5202-6.
    View in: PubMed
  187. Bauer A, McConkey DJ, Howard FD, Clayton LK, Novick D, Koyasu S, Reinherz EL. Differential signal transduction via T-cell receptor CD3 zeta 2, CD3 zeta-eta, and CD3 eta 2 isoforms. Proc Natl Acad Sci U S A. 1991 May 1; 88(9):3842-6.
    View in: PubMed
  188. Arulanandam AR, Koyasu S, Reinherz EL. T cell receptor-independent CD2 signal transduction in FcR+ cells. J Exp Med. 1991 Apr 1; 173(4):859-68.
    View in: PubMed
  189. Moingeon PE, Lucich JL, Stebbins CC, Recny MA, Wallner BP, Koyasu S, Reinherz EL. Complementary roles for CD2 and LFA-1 adhesion pathways during T cell activation. Eur J Immunol. 1991 Mar; 21(3):605-10.
    View in: PubMed
  190. Koyasu S, D'Adamio L, Clayton LK, Reinherz EL. T-cell receptor isoforms and signal transduction. Curr Opin Immunol. 1991 Feb; 3(1):32-9.
    View in: PubMed
  191. Wang JH, Yan YW, Garrett TP, Liu JH, Rodgers DW, Garlick RL, Tarr GE, Husain Y, Reinherz EL, Harrison SC. Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains. Nature. 1990 Nov 29; 348(6300):411-8.
    View in: PubMed
  192. Jin YJ, Koyasu S, Moingeon P, Steinbrich R, Tarr GE, Reinherz EL. A fraction of CD3 epsilon subunits exists as disulfide-linked dimers in both human and murine T lymphocytes. J Biol Chem. 1990 Nov 25; 265(33):20713.
    View in: PubMed
  193. Clayton LK, Bauer A, Jin YJ, D'Adamio L, Koyasu S, Reinherz EL. Characterization of thymus-derived lymphocytes expressing Ti alpha-beta CD3 gamma delta epsilon zeta-zeta, Ti alpha-beta CD3 gamma delta epsilon eta-eta or Ti alpha-beta CD3 gamma delta epsilon zeta-zeta/zeta-eta antigen receptor isoforms: analysis by gene transfection. J Exp Med. 1990 Oct 1; 172(4):1243-53.
    View in: PubMed
  194. Shipp MA, Stefano GB, D'Adamio L, Switzer SN, Howard FD, Sinisterra J, Scharrer B, Reinherz EL. Downregulation of enkephalin-mediated inflammatory responses by CD10/neutral endopeptidase 24.11. Nature. 1990 Sep 27; 347(6291):394-6.
    View in: PubMed
  195. Jin YJ, Koyasu S, Moingeon P, Steinbrich R, Tarr GE, Reinherz EL. A fraction of CD3 epsilon subunits exists as disulfide-linked dimers in both human and murine T lymphocytes. J Biol Chem. 1990 Sep 15; 265(26):15850-3.
    View in: PubMed
  196. Howard FD, Rodewald HR, Kinet JP, Reinherz EL. CD3 zeta subunit can substitute for the gamma subunit of Fc epsilon receptor type I in assembly and functional expression of the high-affinity IgE receptor: evidence for interreceptor complementation. Proc Natl Acad Sci U S A. 1990 Sep; 87(18):7015-9.
    View in: PubMed
  197. Moingeon P, Stebbins CC, D'Adamio L, Lucich J, Reinherz EL. Human natural killer cells and mature T lymphocytes express identical CD3 zeta subunits as defined by cDNA cloning and sequence analysis. Eur J Immunol. 1990 Aug; 20(8):1741-5.
    View in: PubMed
  198. Chang HC, Moingeon P, Pedersen R, Lucich J, Stebbins C, Reinherz EL. Involvement of the PPPGHR motif in T cell activation via CD2. J Exp Med. 1990 Jul 1; 172(1):351-5.
    View in: PubMed
  199. Moingeon P, Jin YJ, Stebbins CC, Lopez PA, Alcover A, Reinherz EL. Characterization of functional GTP binding proteins in Jurkat T cell mutants lacking either CD3-Ti or CD2 surface receptors. Cell Immunol. 1990 Jul; 128(2):578-88.
    View in: PubMed
  200. Recny MA, Neidhardt EA, Sayre PH, Ciardelli TL, Reinherz EL. Structural and functional characterization of the CD2 immunoadhesion domain. Evidence for inclusion of CD2 in an alpha-beta protein folding class. J Biol Chem. 1990 May 25; 265(15):8542-9.
    View in: PubMed
  201. Jin YJ, Clayton LK, Howard FD, Koyasu S, Sieh M, Steinbrich R, Tarr GE, Reinherz EL. Molecular cloning of the CD3 eta subunit identifies a CD3 zeta-related product in thymus-derived cells. Proc Natl Acad Sci U S A. 1990 May; 87(9):3319-23.
    View in: PubMed
  202. Roussel MF, Transy C, Kato JY, Reinherz EL, Sherr CJ. Antibody-induced mitogenicity mediated by a chimeric CD2-c-fms receptor. Mol Cell Biol. 1990 May; 10(5):2407-12.
    View in: PubMed
  203. Callahan KM, Fort MM, Obah EA, Reinherz EL, Siliciano RF. Genetic variability in HIV-1 gp120 affects interactions with HLA molecules and T cell receptor. J Immunol. 1990 May 1; 144(9):3341-6.
    View in: PubMed
  204. Koyasu S, Lawton T, Novick D, Recny MA, Siliciano RF, Wallner BP, Reinherz EL. Role of interaction of CD2 molecules with lymphocyte function-associated antigen 3 in T-cell recognition of nominal antigen. Proc Natl Acad Sci U S A. 1990 Apr; 87(7):2603-7.
    View in: PubMed
  205. Jin YJ, Kaplan DR, White M, Spagnoli GC, Roberts TM, Reinherz EL. Stimulation via CD3-Ti but not CD2 induces rapid tyrosine phosphorylation of a 68-kDa protein in the human Jurkat T cell line. J Immunol. 1990 Jan 15; 144(2):647-52.
    View in: PubMed
  206. Diu A, Février M, Mollier P, Charron D, Banchereau J, Reinherz EL, Thèze J. Further evidence for a human B cell activating factor distinct from IL-4. Cell Immunol. 1990 Jan; 125(1):14-28.
    View in: PubMed
  207. Moingeon P, Chang HC, Sayre PH, Clayton LK, Alcover A, Gardner P, Reinherz EL. The structural biology of CD2. Immunol Rev. 1989 Oct; 111:111-44.
    View in: PubMed
  208. Testi R, Alcover A, Spagnoli G, Reinherz EL, Acuto O. CD3Ti+ human thymocyte-derived clones displaying a differential response to activation via CD3Ti and CD2. Cell Immunol. 1989 Sep; 122(2):350-64.
    View in: PubMed
  209. D'Adamio L, Shipp MA, Masteller EL, Reinherz EL. Organization of the gene encoding common acute lymphoblastic leukemia antigen (neutral endopeptidase 24.11): multiple miniexons and separate 5' untranslated regions. Proc Natl Acad Sci U S A. 1989 Sep; 86(18):7103-7.
    View in: PubMed
  210. Transy C, Moingeon P, Stebbins C, Reinherz EL. Deletion of the cytoplasmic region of the CD3 epsilon subunit does not prevent assembly of a functional T-cell receptor. Proc Natl Acad Sci U S A. 1989 Sep; 86(18):7108-12.
    View in: PubMed
  211. Clayton LK, Sieh M, Pious DA, Reinherz EL. Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding. Nature. 1989 Jun 15; 339(6225):548-51.
    View in: PubMed
  212. Chang HC, Moingeon P, Lopez P, Krasnow H, Stebbins C, Reinherz EL. Dissection of the human CD2 intracellular domain. Identification of a segment required for signal transduction and interleukin 2 production. J Exp Med. 1989 Jun 1; 169(6):2073-83.
    View in: PubMed
  213. Chang HC, Reinherz EL. Isolation and characterization of a cDNA encoding a putative cytokine which is induced by stimulation via the CD2 structure on human T lymphocytes. Eur J Immunol. 1989 Jun; 19(6):1045-51.
    View in: PubMed
  214. Moingeon P, Chang HC, Wallner BP, Stebbins C, Frey AZ, Reinherz EL. CD2-mediated adhesion facilitates T lymphocyte antigen recognition function. Nature. 1989 May 25; 339(6222):312-4.
    View in: PubMed
  215. Transy C, Moingeon PE, Marshall B, Stebbins C, Reinherz EL. Most anti-human CD3 monoclonal antibodies are directed to the CD3 epsilon subunit. Eur J Immunol. 1989 May; 19(5):947-50.
    View in: PubMed
  216. Diamond DJ, Nelson FB, Reinherz EL. Lineage-specific expression of a T cell receptor variable gene promoter controlled by upstream sequences. J Exp Med. 1989 Apr 1; 169(4):1213-31.
    View in: PubMed
  217. Siliciano RF, Knall C, Lawton T, Berman P, Gregory T, Reinherz EL. Recognition of HIV glycoprotein gp120 by T cells. Role of monocyte CD4 in the presentation of gp120. J Immunol. 1989 Mar 1; 142(5):1506-11.
    View in: PubMed
  218. Sayre PH, Hussey RE, Chang HC, Ciardelli TL, Reinherz EL. Structural and binding analysis of a two domain extracellular CD2 molecule. J Exp Med. 1989 Mar 1; 169(3):995-1009.
    View in: PubMed
  219. Gardner P, Alcover A, Kuno M, Moingeon P, Weyand CM, Goronzy J, Reinherz EL. Triggering of T-lymphocytes via either T3-Ti or T11 surface structures opens a voltage-insensitive plasma membrane calcium-permeable channel: requirement for interleukin-2 gene function. J Biol Chem. 1989 Jan 15; 264(2):1068-76.
    View in: PubMed
  220. Byrne JA, Butler JL, Reinherz EL, Cooper MD. Virgin and memory T cells have different requirements for activation via the CD2 molecule. Int Immunol. 1989; 1(1):29-35.
    View in: PubMed
  221. Barker PE, Shipp MA, D'Adamio L, Masteller EL, Reinherz EL. The common acute lymphoblastic leukemia antigen gene maps to chromosomal region 3 (q21-q27). J Immunol. 1989 Jan 1; 142(1):283-7.
    View in: PubMed
  222. Chang HC, Hsu F, Freeman GJ, Griffin JD, Reinherz EL. Cloning and expression of a gamma-interferon-inducible gene in monocytes: a new member of a cytokine gene family. Int Immunol. 1989; 1(4):388-97.
    View in: PubMed
  223. Shipp MA, Vijayaraghavan J, Schmidt EV, Masteller EL, D'Adamio L, Hersh LB, Reinherz EL. Common acute lymphoblastic leukemia antigen (CALLA) is active neutral endopeptidase 24.11 ("enkephalinase"): direct evidence by cDNA transfection analysis. Proc Natl Acad Sci U S A. 1989 Jan; 86(1):297-301.
    View in: PubMed
  224. Reinherz EL, Chang HC, Clayton LK, Gardner P, Howard FD, Koyasu S, Jin YJ, Moingeon P, Sayre PH. The biology of human CD2. Cold Spring Harb Symp Quant Biol. 1989; 54 Pt 2:611-25.
    View in: PubMed
  225. Moingeon P, Alcover A, Clayton LK, Chang HC, Transy C, Reinherz EL. Expression of a functional CD3-Ti antigen/MHC receptor in the absence of surface CD2. Analysis with clonal Jurkat cell mutants. J Exp Med. 1988 Dec 1; 168(6):2077-90.
    View in: PubMed
  226. Clayton LK, Hussey RE, Steinbrich R, Ramachandran H, Husain Y, Reinherz EL. Substitution of murine for human CD4 residues identifies amino acids critical for HIV-gp120 binding. Nature. 1988 Sep 22; 335(6188):363-6.
    View in: PubMed
  227. Siliciano RF, Lawton T, Knall C, Karr RW, Berman P, Gregory T, Reinherz EL. Analysis of host-virus interactions in AIDS with anti-gp120 T cell clones: effect of HIV sequence variation and a mechanism for CD4+ cell depletion. Cell. 1988 Aug 12; 54(4):561-75.
    View in: PubMed
  228. Richardson NE, Brown NR, Hussey RE, Vaid A, Matthews TJ, Bolognesi DP, Reinherz EL. Binding site for human immunodeficiency virus coat protein gp120 is located in the NH2-terminal region of T4 (CD4) and requires the intact variable-region-like domain. Proc Natl Acad Sci U S A. 1988 Aug; 85(16):6102-6.
    View in: PubMed
  229. Richardson NE, Chang HC, Brown NR, Hussey RE, Sayre PH, Reinherz EL. Adhesion domain of human T11 (CD2) is encoded by a single exon. Proc Natl Acad Sci U S A. 1988 Jul; 85(14):5176-80.
    View in: PubMed
  230. Shipp MA, Richardson NE, Sayre PH, Brown NR, Masteller EL, Clayton LK, Ritz J, Reinherz EL. Molecular cloning of the common acute lymphoblastic leukemia antigen (CALLA) identifies a type II integral membrane protein. Proc Natl Acad Sci U S A. 1988 Jul; 85(13):4819-23.
    View in: PubMed
  231. Alcover A, Alberini C, Acuto O, Clayton LK, Transy C, Spagnoli GC, Moingeon P, Lopez P, Reinherz EL. Interdependence of CD3-Ti and CD2 activation pathways in human T lymphocytes. EMBO J. 1988 Jul; 7(7):1973-7.
    View in: PubMed
  232. Clayton LK, Ramachandran H, Pravtcheva D, Chen YF, Diamond DJ, Ruddle FH, Reinherz EL. The gene for T11 (CD2) maps to chromosome 1 in humans and to chromosome 3 in mice. J Immunol. 1988 May 15; 140(10):3617-21.
    View in: PubMed
  233. Alcover A, Chang HC, Sayre PH, Hussey RE, Reinherz EL. The T 11 (CD 2) cDNA encodes a transmembrane protein which expresses T 11(1), T 11(2) and T 11(3) epitopes but which does not independently mediate calcium influx: analysis by gene transfer in a baculovirus system. Eur J Immunol. 1988 Mar; 18(3):363-7.
    View in: PubMed
  234. Diamond DJ, Clayton LK, Sayre PH, Reinherz EL. Exon-intron organization and sequence comparison of human and murine T11 (CD2) genes. Proc Natl Acad Sci U S A. 1988 Mar; 85(5):1615-9.
    View in: PubMed
  235. Hussey RE, Richardson NE, Kowalski M, Brown NR, Chang HC, Siliciano RF, Dorfman T, Walker B, Sodroski J, Reinherz EL. A soluble CD4 protein selectively inhibits HIV replication and syncytium formation. Nature. 1988 Jan 7; 331(6151):78-81.
    View in: PubMed
  236. Sayre PH, Reinherz EL. Structure and function of the erythrocyte receptor CD2 on human T lymphocytes: a review. Scand J Rheumatol Suppl. 1988; 76:131-44.
    View in: PubMed
  237. Ramarli D, Fox DA, Reinherz EL. Selective inhibition of interleukin 2 gene function following thymocyte antigen/major histocompatibility complex receptor crosslinking: possible thymic selection mechanism. Proc Natl Acad Sci U S A. 1987 Dec; 84(23):8598-602.
    View in: PubMed
  238. Diu A, Gougeon ML, Moreau JL, Reinherz EL, Thèze J. Activation of resting human B cells by helper T-cell clone supernatant: characterization of a human B-cell-activating factor. Proc Natl Acad Sci U S A. 1987 Dec; 84(24):9140-4.
    View in: PubMed
  239. Royer HD, Reinherz EL. T lymphocytes: ontogeny, function, and relevance to clinical disorders. N Engl J Med. 1987 Oct 29; 317(18):1136-42.
    View in: PubMed
  240. Shipp MA, Reinherz EL. Differential expression of nuclear proto-oncogenes in T cells triggered with mitogenic and nonmitogenic T3 and T11 activation signals. J Immunol. 1987 Oct 1; 139(7):2143-8.
    View in: PubMed
  241. Clayton LK, Sayre PH, Novotny J, Reinherz EL. Murine and human T11 (CD2) cDNA sequences suggest a common signal transduction mechanism. Eur J Immunol. 1987 Sep; 17(9):1367-70.
    View in: PubMed
  242. Trentham DE, Belli JA, Bloomer WD, Anderson RJ, Lane H, Reinherz EL, Austen KF. 2,000-centiGray total lymphoid irradiation for refractory rheumatoid arthritis. Arthritis Rheum. 1987 Sep; 30(9):980-7.
    View in: PubMed
  243. Reinherz EL, Bensussan A. Clonal analysis of B cell growth and differentiation activities induced from T lymphocytes upon triggering of T3-Ti and T11 pathways. J Immunol. 1987 Aug; 139(4):1375.
    View in: PubMed
  244. Reem GH, Carding S, Reinherz EL. Lymphokine synthesis is induced in human thymocytes by activation of the CD 2 (T11) pathway. J Immunol. 1987 Jul 1; 139(1):130-4.
    View in: PubMed
  245. Pecht I, Corcia A, Liuzzi MP, Alcover A, Reinherz EL. Ion channels activated by specific Ti or T3 antibodies in plasma membranes of human T cells. EMBO J. 1987 Jul; 6(7):1935-9.
    View in: PubMed
  246. Royer HD, Reinherz EL. The human T cell receptor for antigen: structure, ontogeny and gene expression. Behring Inst Mitt. 1987 Jun; (81):1-14.
    View in: PubMed
  247. Sayre PH, Chang HC, Hussey RE, Brown NR, Richardson NE, Spagnoli G, Clayton LK, Reinherz EL. Molecular cloning and expression of T11 cDNAs reveal a receptor-like structure on human T lymphocytes. Proc Natl Acad Sci U S A. 1987 May; 84(9):2941-5.
    View in: PubMed
  248. Alcover A, Ramarli D, Richardson NE, Chang HC, Reinherz EL. Functional and molecular aspects of human T lymphocyte activation via T3-Ti and T11 pathways. Immunol Rev. 1987 Feb; 95:5-36.
    View in: PubMed
  249. Reinherz EL. T-cell receptors. Who needs more? Nature. 1987 Feb 19-25; 325(6106):660-3.
    View in: PubMed
  250. Milanese C, Siliciano RF, Richardson NE, Chang HC, Alcover A, Reinherz EL. Human T lymphocyte activation. Adv Exp Med Biol. 1987; 213:59-68.
    View in: PubMed
  251. Schmidt RE, Michon JM, Woronicz J, Schlossman SF, Reinherz EL, Ritz J. Enhancement of natural killer function through activation of the T11 E rosette receptor. J Clin Invest. 1987 Jan; 79(1):305-8.
    View in: PubMed
  252. Reinherz EL. Retraction: A lymphokine that activates the cytolytic program of both cytotoxic T lymphocyte and natural killer clones. J Exp Med. 1987 Jan 1; 165(1):275.
    View in: PubMed
  253. Schmidt RE, Schlossman SF, Reinherz EL, Ritz J. Activation of natural killer function through the T11/E rosette receptor. Haematol Blood Transfus. 1987; 31:347-50.
    View in: PubMed
  254. Royer HD, Reinherz EL. Multiple nuclear proteins bind upstream sequences in the promotor region of a T-cell receptor beta-chain variable-region gene: evidence for tissue specificity. Proc Natl Acad Sci U S A. 1987 Jan; 84(1):232-6.
    View in: PubMed
  255. Milanese C, Richardson NE, Reinherz EL. Retraction of data. Science. 1986 Nov 28; 234(4780):1056.
    View in: PubMed
  256. Siliciano RF, Hemesath TJ, Pratt JC, Dintzis RZ, Dintzis HM, Acuto O, Shin HS, Reinherz EL. Direct evidence for the existence of nominal antigen binding sites on T cell surface Ti alpha-beta heterodimers of MHC-restricted T cell clones. Cell. 1986 Oct 24; 47(2):161-71.
    View in: PubMed
  257. Ramarli D, Fox DA, Milanese C, Reinherz EL. Selective inhibition of interleukin 2 gene function following thymocyte antigen/major histocompatibility complex receptor crosslinking: possible thymic selection mechanism. Proc Natl Acad Sci U S A. 1986 Sep; 83(18):7008-12.
    View in: PubMed
  258. Hafler DA, Fallis RJ, Dawson DM, Schlossman SF, Reinherz EL, Weiner HL. Immunologic responses of progressive multiple sclerosis patients treated with an anti-T-cell monoclonal antibody, anti-T12. Neurology. 1986 Jun; 36(6):777-84.
    View in: PubMed
  259. Milanese C, Siliciano RF, Schmidt RE, Ritz J, Richardson NE, Reinherz EL. A lymphokine that activates the cytolytic program of both cytotoxic T lymphocyte and natural killer clones. J Exp Med. 1986 Jun 1; 163(6):1583-8.
    View in: PubMed
  260. Alcover A, Milanese C, Reinherz EL. Pathways of human T lymphocyte development and activation. Bioessays. 1986 Jun; 4(6):259-64.
    View in: PubMed
  261. Leca G, Boumsell L, Fabbi M, Reinherz EL, Kanellopoulos JM. The sheep erythrocyte receptor and both alpha and beta chains of the human T-lymphocyte antigen receptor bind the mitogenic lectin (phytohaemagglutinin) from Phaseolus vulgaris. Scand J Immunol. 1986 May; 23(5):535-44.
    View in: PubMed
  262. Schmidt RE, Bartley GT, Lee SS, Daley JF, Royer HD, Levine H, Reinherz EL, Schlossman SF, Ritz J. Expression of the NKTa clonotype in a series of human natural killer clones with identical cytotoxic specificity. J Exp Med. 1986 Apr 1; 163(4):812-25.
    View in: PubMed
  263. Alcover A, Weiss MJ, Daley JF, Reinherz EL. The T11 glycoprotein is functionally linked to a calcium channel in precursor and mature T-lineage cells. Proc Natl Acad Sci U S A. 1986 Apr; 83(8):2614-8.
    View in: PubMed
  264. Fox DA, Schlossman SF, Reinherz EL. Regulation of the alternative pathway of T cell activation by anti-T3 monoclonal antibody. J Immunol. 1986 Mar 15; 136(6):1945-50.
    View in: PubMed
  265. Milanese C, Richardson NE, Reinherz EL. Identification of a T helper cell-derived lymphokine that activates resting T lymphocytes. Science. 1986 Mar 7; 231(4742):1118-22.
    View in: PubMed
  266. Reinherz EL. Surface receptors involved in human T lymphocyte activation. Mt Sinai J Med. 1986 Mar; 53(3):210-5.
    View in: PubMed
  267. Reinherz EL, Royer HD, Campen TJ, Ramarli D, Chang HC, Acuto O. The structure and function of the T3-Ti molecular complex on human T lymphocytes. Symp Fundam Cancer Res. 1986; 38:3-30.
    View in: PubMed
  268. Reinherz EL, Royer HD, Campen TJ, Ramarli D, Fabbi M, Acuto O. The ontogeny, structure and function of the human T lymphocyte receptor for antigen and major histocompatibility complex. Biochem Soc Symp. 1986; 51:211-32.
    View in: PubMed
  269. Ythier A, Delmon L, Reinherz E, Nowill A, Moingeon P, Mishal Z, Bohuon C, Hercend T. Proliferative responses of circulating human NK cells: delineation of a unique pathway involving both direct and helper signals. Eur J Immunol. 1985 Dec; 15(12):1209-15.
    View in: PubMed
  270. Wilson M, Rosen FS, Schlossman SF, Reinherz EL. Ontogeny of human T and B lymphocytes during stressed and normal gestation: phenotypic analysis of umbilical cord lymphocytes from term and preterm infants. Clin Immunol Immunopathol. 1985 Oct; 37(1):1-12.
    View in: PubMed
  271. Acuto O, Hussey RE, Reinherz EL. Multiple class I and class II major histocompatibility complex allospecificities are generated with T cell receptor variable (V) domains created by a single Ti beta V gene family. J Exp Med. 1985 Oct 1; 162(4):1387-92.
    View in: PubMed
  272. Siliciano RF, Pratt JC, Schmidt RE, Ritz J, Reinherz EL. Activation of cytolytic T lymphocyte and natural killer cell function through the T11 sheep erythrocyte binding protein. Nature. 1985 Oct 3-9; 317(6036):428-30.
    View in: PubMed
  273. Letvin NL, Ritz J, Guida LJ, Yetz JM, Lambert JM, Reinherz EL, Schlossman SF. In vivo administration of lymphocyte-specific monoclonal antibodies in nonhuman primates: I. Effects of anti-T11 antibodies on the circulating T cell pool. Blood. 1985 Oct; 66(4):961-6.
    View in: PubMed
  274. Milanese C, Bensussan A, Reinherz EL. Clonal analysis of B cell growth and differentiation activities induced from T lymphocytes upon triggering of T3-Ti and T11 pathways. J Immunol. 1985 Sep; 135(3):1884-90.
    View in: PubMed
  275. Royer HD, Ramarli D, Acuto O, Campen TJ, Reinherz EL. Genes encoding the T-cell receptor alpha and beta subunits are transcribed in an ordered manner during intrathymic ontogeny. Proc Natl Acad Sci U S A. 1985 Aug; 82(16):5510-4.
    View in: PubMed
  276. Bensussan A, Milanese C, Meuer SC, Reinherz EL. MHC class II gene products specific autoreactive T cell clones provide inducer as well as amplifier function for B cell Ig production. Behring Inst Mitt. 1985 Aug; (77):93-104.
    View in: PubMed
  277. Royer HD, Campen TJ, Ramarli D, Chang HC, Acuto O, Reinherz EL. The human T lymphocyte receptor complex for antigen and MHC. Behring Inst Mitt. 1985 Aug; (77):1-21.
    View in: PubMed
  278. Fabbi M, Acuto O, Bensussan A, Poole CB, Reinherz EL. Production and characterization of antibody probes directed at constant regions of the alpha and beta subunit of the human T cell receptor. Eur J Immunol. 1985 Aug; 15(8):821-7.
    View in: PubMed
  279. Schmidt RE, Hercend T, Fox DA, Bensussan A, Bartley G, Daley JF, Schlossman SF, Reinherz EL, Ritz J. The role of interleukin 2 and T11 E rosette antigen in activation and proliferation of human NK clones. J Immunol. 1985 Jul; 135(1):672-8.
    View in: PubMed
  280. Barker PE, Royer HD, Ruddle FH, Reinherz EL. Regional location of T cell receptor gene Ti alpha on human chromosome 14. J Exp Med. 1985 Jul 1; 162(1):387-92.
    View in: PubMed
  281. Ritz J, Campen TJ, Schmidt RE, Royer HD, Hercend T, Hussey RE, Reinherz EL. Analysis of T-cell receptor gene rearrangement and expression in human natural killer clones. Science. 1985 Jun 28; 228(4707):1540-3.
    View in: PubMed
  282. Royer HD, Campen TJ, Ramarli D, Chang HC, Acuto O, Reinherz EL. Molecular aspects of human T lymphocyte antigen recognition. Transplantation. 1985 Jun; 39(6):571-82.
    View in: PubMed
  283. Acuto O, Campen TJ, Royer HD, Hussey RE, Poole CB, Reinherz EL. Molecular analysis of T cell receptor (Ti) variable region (V) gene expression. Evidence that a single Ti beta V gene family can be used in formation of V domains on phenotypically and functionally diverse T cell populations. J Exp Med. 1985 Jun 1; 161(6):1326-43.
    View in: PubMed
  284. Hafler DA, Fox DA, Manning ME, Schlossman SF, Reinherz EL, Weiner HL. In vivo activated T lymphocytes in the peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. N Engl J Med. 1985 May 30; 312(22):1405-11.
    View in: PubMed
  285. Acuto O, Fabbi M, Bensussan A, Milanese C, Campen TJ, Royer HD, Reinherz EL. The human T-cell receptor. J Clin Immunol. 1985 May; 5(3):141-57.
    View in: PubMed
  286. Acuto O, Reinherz EL. The human T-cell receptor. Structure and function. N Engl J Med. 1985 Apr 25; 312(17):1100-11.
    View in: PubMed
  287. Smolen JS, Morimoto C, Steinberg AD, Wolf A, Schlossman SF, Steinberg RT, Penner E, Reinherz E, Reichlin M, Chused TM. Systemic lupus erythematosus: delineation of subpopulations by clinical, serologic, and T cell subset analysis. Am J Med Sci. 1985 Apr; 289(4):139-47.
    View in: PubMed
  288. Morimoto C, Matsuyama T, Oshige C, Tanaka H, Hercend T, Reinherz EL, Schlossman SF. Functional and phenotypic studies of Japanese adult T cell leukemia cells. J Clin Invest. 1985 Mar; 75(3):836-43.
    View in: PubMed
  289. Sayre PH, Reinherz EL. Structural invariance of T4 molecules from T cell clones of different antigen and major histocompatibility complex specificities. Eur J Immunol. 1985 Mar; 15(3):291-5.
    View in: PubMed
  290. Acuto O, Fabbi M, Schlossman SF, Reinherz EL. Molecular analysis of the human T-cell-antigen receptor. Biochem Soc Trans. 1985 Feb; 13(1):6-10.
    View in: PubMed
  291. Bensussan A, Bourge JF, Reinherz EL, Degos L, Sasportes M. [Phorbol diester induces phenotypic and functional changes in human T-lymphocyte clones]. C R Acad Sci III. 1985; 301(4):121-4.
    View in: PubMed
  292. Fox DA, Hussey RE, Fitzgerald KA, Bensussan A, Daley JF, Schlossman SF, Reinherz EL. Activation of human thymocytes via the 50KD T11 sheep erythrocyte binding protein induces the expression of interleukin 2 receptors on both T3+ and T3- populations. J Immunol. 1985 Jan; 134(1):330-5.
    View in: PubMed
  293. Royer HD, Acuto O, Fabbi M, Tizard R, Ramachandran K, Smart JE, Reinherz EL. Genes encoding the Ti beta subunit of the antigen/MHC receptor undergo rearrangement during intrathymic ontogeny prior to surface T3-Ti expression. Cell. 1984 Dec; 39(2 Pt 1):261-6.
    View in: PubMed
  294. Fabbi M, Acuto O, Smart JE, Reinherz EL. Homology of Ti alpha-subunit of a T-cell antigen-MHC receptor with immunoglobulin. Nature. 1984 Nov 15-21; 312(5991):269-71.
    View in: PubMed
  295. Weiss MJ, Daley JF, Hodgdon JC, Reinherz EL. Calcium dependency of antigen-specific (T3-Ti) and alternative (T11) pathways of human T-cell activation. Proc Natl Acad Sci U S A. 1984 Nov; 81(21):6836-40.
    View in: PubMed
  296. Barker PE, Ruddle FH, Royer HD, Acuto O, Reinherz EL. Chromosomal location of human T-cell receptor gene Ti beta. Science. 1984 Oct 19; 226(4672):348-9.
    View in: PubMed
  297. Griffin JD, Meuer SC, Schlossman SF, Reinherz EL. T cell regulation of myelopoiesis: analysis at a clonal level. J Immunol. 1984 Oct; 133(4):1863-8.
    View in: PubMed
  298. Reinherz EL, Acuto O, Fabbi M, Bensussan A, Milanese C, Royer HD, Meuer SC, Schlossman SF. Clonotypic surface structure on human T lymphocytes: functional and biochemical analysis of the antigen receptor complex. Immunol Rev. 1984 Oct; 81:95-129.
    View in: PubMed
  299. Morimoto C, Distaso JA, Cheney JJ, Reinherz EL, Schlossman SF. Cellular interaction between subsets of T8 population for maximal suppression of antigen-specific antibody response. Cell Immunol. 1984 Oct 1; 88(1):75-84.
    View in: PubMed
  300. Bensussan A, Acuto O, Hussey RE, Milanese C, Reinherz EL. T3-Ti receptor triggering of T8+ suppressor T cells leads to unresponsiveness to interleukin-2. Nature. 1984 Oct 11-17; 311(5986):565-7.
    View in: PubMed
  301. Hercend T, Schmidt R, Brennan A, Edson MA, Reinherz EL, Schlossman SF, Ritz J. Identification of a 140-kDa activation antigen as a target structure for a series of human cloned natural killer cell lines. Eur J Immunol. 1984 Sep; 14(9):844-52.
    View in: PubMed
  302. Fox DA, Hussey RE, Fitzgerald KA, Acuto O, Poole C, Palley L, Daley JF, Schlossman SF, Reinherz EL. Ta1, a novel 105 KD human T cell activation antigen defined by a monoclonal antibody. J Immunol. 1984 Sep; 133(3):1250-6.
    View in: PubMed
  303. Romain PL, Schlossman SF, Reinherz EL. Surface molecules involved in self-recognition and T cell activation in the autologous mixed lymphocyte reaction. J Immunol. 1984 Sep; 133(3):1093-100.
    View in: PubMed
  304. Royer HD, Bensussan A, Acuto O, Reinherz EL. Functional isotypes are not encoded by the constant region genes of the beta subunit of the T cell receptor for antigen/major histocompatibility complex. J Exp Med. 1984 Sep 1; 160(3):947-52.
    View in: PubMed
  305. Rimm IJ, Schlossman SF, Reinherz EL. Natural killer-like activity mediated by activated T lymphocytes. Cell Immunol. 1984 Sep; 87(2):327-39.
    View in: PubMed
  306. Hercend T, Meuer S, Brennan A, Edson MA, Acuto O, Reinherz EL, Schlossman SF, Ritz J. Natural killer-like function of activated T lymphocytes: differential blocking effects of monoclonal antibodies specific for a 90-kDa clonotypic structure. Cell Immunol. 1984 Jul; 86(2):381-92.
    View in: PubMed
  307. Acuto O, Fabbi M, Smart J, Poole CB, Protentis J, Royer HD, Schlossman SF, Reinherz EL. Purification and NH2-terminal amino acid sequencing of the beta subunit of a human T-cell antigen receptor. Proc Natl Acad Sci U S A. 1984 Jun; 81(12):3851-5.
    View in: PubMed
  308. Brahn E, Helfgott SM, Belli JA, Anderson RJ, Reinherz EL, Schlossman SF, Austen KF, Trentham DE. Total lymphoid irradiation therapy in refractory rheumatoid arthritis. Fifteen- to forty-month followup. Arthritis Rheum. 1984 May; 27(5):481-8.
    View in: PubMed
  309. Meuer SC, Hussey RE, Fabbi M, Fox D, Acuto O, Fitzgerald KA, Hodgdon JC, Protentis JP, Schlossman SF, Reinherz EL. An alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein. Cell. 1984 Apr; 36(4):897-906.
    View in: PubMed
  310. Rimm IJ, Bhan AK, Schneeberger EE, Schlossman SF, Reinherz EL. Characterization of human thymic epithelial cells grown in serum-free medium. Clin Immunol Immunopathol. 1984 Apr; 31(1):56-64.
    View in: PubMed
  311. Meuer SC, Hussey RE, Cantrell DA, Hodgdon JC, Schlossman SF, Smith KA, Reinherz EL. Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway. Proc Natl Acad Sci U S A. 1984 Mar; 81(5):1509-13.
    View in: PubMed
  312. Morimoto C, Reinherz EL, Distaso JA, Steinberg AD, Schlossman SF. Relationship between systemic lupus erythematosus T cell subsets, anti-T cell antibodies, and T cell functions. J Clin Invest. 1984 Mar; 73(3):689-700.
    View in: PubMed
  313. Bensussan A, Meuer SC, Schlossman SF, Reinherz EL. Delineation of an immunoregulatory amplifier population recognizing autologous Ia molecules. Analysis with human T cell clones. J Exp Med. 1984 Feb 1; 159(2):559-76.
    View in: PubMed
  314. Romain PL, Morimoto C, Daley JF, Palley LS, Reinherz EL, Schlossman SF. Reactivity of inducer cell subsets and T8-cell activation during the human autologous mixed lymphocyte reaction. Clin Immunol Immunopathol. 1984 Jan; 30(1):117-28.
    View in: PubMed
  315. Meuer SC, Acuto O, Hercend T, Schlossman SF, Reinherz EL. The human T-cell receptor. Annu Rev Immunol. 1984; 2:23-50.
    View in: PubMed
  316. Schlossman SF, Reinherz EL. Human T-cell subsets in health and disease. Springer Semin Immunopathol. 1984; 7(1):9-18.
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  317. Nicholson JK, McDougal JS, Spira TJ, Cross GD, Jones BM, Reinherz EL. Immunoregulatory subsets of the T helper and T suppressor cell populations in homosexual men with chronic unexplained lymphadenopathy. J Clin Invest. 1984 Jan; 73(1):191-201.
    View in: PubMed
  318. Meuer SC, Cooper DA, Hodgdon JC, Hussey RE, Fitzgerald KA, Schlossman SF, Reinherz EL. Identification of the receptor for antigen and major histocompatibility complex on human inducer T lymphocytes. Science. 1983 Dec 16; 222(4629):1239-42.
    View in: PubMed
  319. Kirkman RL, Araujo JL, Busch GJ, Carpenter CB, Milford EL, Reinherz EL, Schlossman SF, Strom TB, Tilney NL. Treatment of acute renal allograft rejection with monoclonal anti-T12 antibody. Transplantation. 1983 Dec; 36(6):620-6.
    View in: PubMed
  320. Hercend T, Meuer S, Brennan A, Edson MA, Acuto O, Reinherz EL, Schlossman SF, Ritz J. Identification of a clonally restricted 90 kD heterodimer on two human cloned natural killer cell lines. Its role in cytotoxic effector function. J Exp Med. 1983 Nov 1; 158(5):1547-60.
    View in: PubMed
  321. Acuto O, Meuer SC, Hodgdon JC, Schlossman SF, Reinherz EL. Peptide variability exists within alpha and beta subunits of the T cell receptor for antigen. J Exp Med. 1983 Oct 1; 158(4):1368-73.
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  322. Hauser SL, Bhan AK, Gilles FH, Hoban CJ, Reinherz EL, Schlossman SF, Weiner HL. Immunohistochemical staining of human brain with monoclonal antibodies that identify lymphocytes, monocytes, and the Ia antigen. J Neuroimmunol. 1983 Oct; 5(2):197-205.
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  323. Acuto O, Hussey RE, Fitzgerald KA, Protentis JP, Meuer SC, Schlossman SF, Reinherz EL. The human T cell receptor: appearance in ontogeny and biochemical relationship of alpha and beta subunits on IL-2 dependent clones and T cell tumors. Cell. 1983 Oct; 34(3):717-26.
    View in: PubMed
  324. Meuer SC, Cooper DA, Hodgdon JC, Hussey RE, Morimoto C, Schlossman SF, Reinherz EL. Immunoregulatory human T lymphocytes triggered as a consequence of viral infection: clonal analysis of helper, suppressor inducer and suppressor effector cell populations. J Immunol. 1983 Sep; 131(3):1167-72.
    View in: PubMed
  325. Meuer SC, Hodgdon JC, Hussey RE, Protentis JP, Schlossman SF, Reinherz EL. Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones. J Exp Med. 1983 Sep 1; 158(3):988-93.
    View in: PubMed
  326. Morimoto C, Reinherz EL, Todd RF, Distaso JA, Schlossman SF. Generation of antigen-specific suppressor cells in vitro in man. J Immunol. 1983 Sep; 131(3):1209-13.
    View in: PubMed
  327. Reinherz EL, Meuer SC, Fitzgerald KA, Hussey RE, Hodgdon JC, Acuto O, Schlossman SF. Comparison of T3-associated 49- and 43-kilodalton cell surface molecules on individual human T-cell clones: evidence for peptide variability in T-cell receptor structures. Proc Natl Acad Sci U S A. 1983 Jul; 80(13):4104-8.
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  328. Bast RC, Reinherz EL, Maver C, Lavin P, Schlossman SF. Contrasting effects of cyclophosphamide and prednisolone on the phenotype of human peripheral blood leukocytes. Clin Immunol Immunopathol. 1983 Jul; 28(1):101-14.
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  329. Meuer SC, Hodgdon JC, Cooper DA, Hussey RE, Fitzgerald KA, Schlossman SF, Reinherz EL. Human cytotoxic T cell clones directed at autologous virus-transformed targets: further evidence for linkage of genetic restriction to T4 and T8 surface glycoproteins. J Immunol. 1983 Jul; 131(1):186-90.
    View in: PubMed
  330. Meuer SC, Acuto O, Hussey RE, Hodgdon JC, Fitzgerald KA, Schlossman SF, Reinherz EL. Evidence for the T3-associated 90K heterodimer as the T-cell antigen receptor. Nature. 1983 Jun 30; 303(5920):808-10.
    View in: PubMed
  331. Traugott U, Reinherz EL, Raine CS. Multiple sclerosis. Distribution of T cells, T cell subsets and Ia-positive macrophages in lesions of different ages. J Neuroimmunol. 1983 Jun; 4(3):201-21.
    View in: PubMed
  332. Geha RS, Reinherz E. Identification of circulating maternal T and B lymphocytes in uncomplicated severe combined immunodeficiency by HLA typing of subpopulations of T cells separated by the fluorescence-activated cell sorter and of Epstein Barr virus-derived B cell lines. J Immunol. 1983 Jun; 130(6):2493-5.
    View in: PubMed
  333. Hauser SL, Reinherz EL, Hoban CJ, Schlossman SF, Weiner HL. CSF cells in multiple sclerosis: monoclonal antibody analysis and relationship to peripheral blood T-cell subsets. Neurology. 1983 May; 33(5):575-9.
    View in: PubMed
  334. Posner MR, Reinherz E, Lane H, Mauch P, Hellman S, Schlossman SF. Circulating lymphocyte populations in Hodgkin's disease after mantle and paraaortic irradiation. Blood. 1983 Apr; 61(4):705-8.
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  335. Griffin JD, Tantravahi R, Canellos GP, Wisch JS, Reinherz EL, Sherwood G, Beveridge RP, Daley JF, Lane H, Schlossman SF. T-cell surface antigens in a patient with blast crisis of chronic myeloid leukemia. Blood. 1983 Apr; 61(4):640-4.
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  336. Letvin NL, King NW, Reinherz EL, Hunt RD, Lane H, Schlossman SF. T lymphocyte surface antigens in primates. Eur J Immunol. 1983 Apr; 13(4):345-7.
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  337. Hauser SL, Reinherz EL, Hoban CJ, Schlossman SF, Weiner HL. Immunoregulatory T-cells and lymphocytotoxic antibodies in active multiple sclerosis: weekly analysis over a six-month period. Ann Neurol. 1983 Apr; 13(4):418-25.
    View in: PubMed
  338. Meuer SC, Fitzgerald KA, Hussey RE, Hodgdon JC, Schlossman SF, Reinherz EL. Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex. J Exp Med. 1983 Feb 1; 157(2):705-19.
    View in: PubMed
  339. Traugott U, Reinherz EL, Raine CS. Multiple sclerosis: distribution of T cell subsets within active chronic lesions. Science. 1983 Jan 21; 219(4582):308-10.
    View in: PubMed
  340. Hercend T, Reinherz EL, Meuer S, Schlossman SF, Ritz J. Phenotypic and functional heterogeneity of human cloned natural killer cell lines. Nature. 1983 Jan 13; 301(5896):158-60.
    View in: PubMed
  341. Morimoto C, Reinherz EL, Borel Y, Schlossman SF. Direct demonstration of the human suppressor inducer subset by anti-T cell antibodies. J Immunol. 1983 Jan; 130(1):157-61.
    View in: PubMed
  342. Reinherz EL, Meuer SC, Schlossman SF. The human T cell receptor: analysis with cytotoxic T cell clones. Immunol Rev. 1983; 74:83-112.
    View in: PubMed
  343. Carpenter CB, Milford EL, Reinherz EL, Schlossman SF, Tilney NL, Strom TB, Kirkman RL, Busch GJ, Araujo JL. Monoclonal anti-T12 antibody as therapy for renal allograft rejection. Trans Assoc Am Physicians. 1983; 96:84-92.
    View in: PubMed
  344. Traugott U, Reinherz EL, Raine CS. Monoclonal anti-T cell antibodies are applicable to the study of inflammatory infiltrates in the central nervous system. J Neuroimmunol. 1982 Dec; 3(4):365-73.
    View in: PubMed
  345. Hauser SL, Ropper AH, Perlo VP, Reinherz EL, Schlossman SF, Weiner HL. T-cell subsets in human autoimmune diseases. Neurology. 1982 Nov; 32(11):1320-1.
    View in: PubMed
  346. Meuer SC, Hussey RE, Hodgdon JC, Hercend T, Schlossman SF, Reinherz EL. Surface structures involved in target recognition by human cytotoxic T lymphocytes. Science. 1982 Oct 29; 218(4571):471-3.
    View in: PubMed
  347. Reinherz EL, Meuer S, Fitzgerald KA, Hussey RE, Levine H, Schlossman SF. Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex. Cell. 1982 Oct; 30(3):735-43.
    View in: PubMed
  348. Reinherz EL, Geha R, Rappeport JM, Wilson M, Penta AC, Hussey RE, Fitzgerald KA, Daley JF, Levine H, Rosen FS, Schlossman SF. Reconstitution after transplantation with T-lymphocyte-depleted HLA haplotype-mismatched bone marrow for severe combined immunodeficiency. Proc Natl Acad Sci U S A. 1982 Oct; 79(19):6047-51.
    View in: PubMed
  349. Hercend T, Meuer S, Reinherz EL, Schlossman SF, Ritz J. Generation of a cloned NK cell line derived from the "null cell" fraction of human peripheral blood. J Immunol. 1982 Sep; 129(3):1299-305.
    View in: PubMed
  350. Meuer SC, Hussey RE, Penta AC, Fitzgerald KA, Stadler BM, Schlossman SF, Reinherz EL. Cellular origin of interleukin 2 (IL 2) in man: evidence for stimulus-restricted IL 2 production by T4+ and T8+ T lymphocytes. J Immunol. 1982 Sep; 129(3):1076-9.
    View in: PubMed
  351. Umiel T, Daley JF, Bhan AK, Levey RH, Schlossman SF, Reinherz EL. Acquisition of immune competence by a subset of human cortical thymocytes expressing mature T cell antigens. J Immunol. 1982 Sep; 129(3):1054-60.
    View in: PubMed
  352. Meuer SC, Schlossman SF, Reinherz EL. Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions. Proc Natl Acad Sci U S A. 1982 Jul; 79(14):4395-9.
    View in: PubMed
  353. Hauser SL, Bresnan MJ, Reinherz EL, Weiner HL. Childhood multiple sclerosis: clinical features and demonstration of changes in T cell subsets with disease activity. Ann Neurol. 1982 May; 11(5):463-8.
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  354. Wallace JI, Coral FS, Rimm IR, Lane H, Levine H, Reinherz EL, Schlossman SF, Sonnabend J. T-cell ratios in homosexuals. Lancet. 1982 Apr 17; 1(8277):908.
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  355. Leung DY, Siegel RL, Grady S, Krensky A, Meade R, Reinherz EL, Geha RS. Immunoregulatory abnormalities in mucocutaneous lymph node syndrome. Clin Immunol Immunopathol. 1982 Apr; 23(1):100-12.
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  356. Morimoto C, Distaso JA, Borel Y, Schlossman SF, Reinherz EL. Communicative interactions between subpopulations of human T lymphocytes required for generation of suppressor effector function in a primary antibody response. J Immunol. 1982 Apr; 128(4):1645-50.
    View in: PubMed
  357. Reinherz EL, Schlossman SF. The characterization and function of human immunoregulatory T lymphocyte subsets. Pharmacol Rev. 1982 Mar; 34(1):17-22.
    View in: PubMed
  358. Morimoto C, Reinherz EL, Nadler LM, Distaso JA, Steinberg AD, Schlossman SF. Comparison in T- and B-cell markers in patients with Sjögren's syndrome and systemic lupus erythematosus. Clin Immunol Immunopathol. 1982 Feb; 22(2):270-8.
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  359. Poppema S, Bhan AK, Reinherz EL, Posner MR, Schlossman SF. In situ immunologic characterization of cellular constituents in lymph nodes and spleens involved by Hodgkin's disease. Blood. 1982 Feb; 59(2):226-32.
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  360. Bhan AK, Dienstag JL, Wands JR, Schlossman SF, Reinherz EL. Alterations of T-cell subsets in primary biliary cirrhosis. Clin Exp Immunol. 1982 Feb; 47(2):351-8.
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  361. Reinherz EL, Morimoto C, Fitzgerald KA, Hussey RE, Daley JF, Schlossman SF. Heterogeneity of human T4+ inducer T cells defined by a monoclonal antibody that delineates two functional subpopulations. J Immunol. 1982 Jan; 128(1):463-8.
    View in: PubMed
  362. Reinherz EL, Hussey RE, Fitzgerald K, Snow P, Terhorst C, Schlossman SF. Antibody directed at a surface structure inhibits cytolytic but not suppressor function of human T lymphocytes. Nature. 1981 Nov 12; 294(5837):168-70.
    View in: PubMed
  363. Reinherz EL, Penta AC, Hussey RE, Schlossman SF. A rapid method for separating functionally intact human T lymphocytes with monoclonal antibodies. Clin Immunol Immunopathol. 1981 Nov; 21(2):257-66.
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  364. Reinherz EL, Schlossman SF. Derivation of human T-cell leukemias. Cancer Res. 1981 Nov; 41(11 Pt 2):4767-70.
    View in: PubMed
  365. Hercend T, Ritz J, Schlossman SF, Reinherz EL. Comparative expression of T9, T10, and Ia antigens on activated human T cell subsets. Hum Immunol. 1981 Nov; 3(3):247-59.
    View in: PubMed
  366. Hercend T, Nadler LM, Pesando JM, Reinherz EL, Schlossman SF, Ritz J. Expression of a 26,000-dalton glycoprotein on activated human T cells. Cell Immunol. 1981 Oct; 64(1):192-9.
    View in: PubMed
  367. Reinherz EL, Rosen FS. New concepts of immunodeficiency. Am J Med. 1981 Oct; 71(4):511-3.
    View in: PubMed
  368. Rimm IJ, Schlossman SF, Reinherz EL. Antibody-dependent cellular cytotoxicity and natural-killer-like activity are mediated by subsets of activated T cells. Clin Immunol Immunopathol. 1981 Oct; 21(1):134-40.
    View in: PubMed
  369. Geha RS, Reinherz E, Leung D, McKee KT, Schlossman S, Rosen FS. Deficiency of suppressor T cells in the hyperimmunoglobulin E syndrome. J Clin Invest. 1981 Sep; 68(3):783-91.
    View in: PubMed
  370. Posner MR, Reinherz EL, Breard J, Nadler LM, Rosenthal DS, Schlossman SF. Lymphoid subpopulations of peripheral blood and spleen in untreated Hodgkin's disease. Cancer. 1981 Sep 1; 48(5):1170-6.
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  371. Reinherz EL, Cooper MD, Schlossman SF, Rosen FS. Abnormalities of T cell maturation and regulation in human beings with immunodeficiency disorders. J Clin Invest. 1981 Sep; 68(3):699-705.
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  372. Fischer A, Durandy A, Virelizier JL, De Saint Basile G, Lagrue A, Reinherz E, Schlossman S, Griscelli C. Severe combined immunodeficiency with quantitatively normal but abnormally differentiated T lymphocytes. J Pediatr. 1981 Aug; 99(2):261-4.
    View in: PubMed
  373. Morimoto C, Reinherz EL, Schlossman SF. Primary in vitro anti-KLH antibody formation by peripheral blood lymphocytes in man: detection with a radioimmunoassay. J Immunol. 1981 Aug; 127(2):514-7.
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  374. Morimoto C, Reinherz EL, Schlossman SF. Regulation of in vitro primary anti-DNP antibody production by functional subsets of T lymphocytes in man. J Immunol. 1981 Jul; 127(1):69-73.
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  375. Bernard A, Boumsell L, Reinherz EL, Nadler LM, Ritz J, Coppin H, Richard Y, Valensi F, Dausset J, Flandrin G, Lemerle J, Schlossman SF. Cell surface characterization of malignant T cells from lymphoblastic lymphoma using monoclonal antibodies: evidence for phenotypic differences between malignant T cells from patients with acute lymphoblastic leukemia and lymphoblastic lymphoma. Blood. 1981 Jun; 57(6):1105-10.
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  376. Reinherz EL, Geha R, Wohl ME, Morimoto C, Rosen FS, Schlossman SF. Immunodeficiency associated with loss of T4+ inducer T-cell function. N Engl J Med. 1981 Apr 2; 304(14):811-6.
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  377. Terhorst C, van Agthoven A, LeClair K, Snow P, Reinherz E, Schlossman S. Biochemical studies of the human thymocyte cell-surface antigens T6, T9 and T10. Cell. 1981 Mar; 23(3):771-80.
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  378. Boumsell L, Bernard A, Reinherz EL, Nadler LM, Ritz J, Coppin H, Richard Y, Dubertret L, Valensi F, Degos L, Lemerle J, Flandrin G, Dausset J, Schlossman SF. Surface antigens on malignant Sézary and T-CLL cells correspond to those of mature T cells. Blood. 1981 Mar; 57(3):526-30.
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  379. Morimoto C, Reinherz EL, Borel Y, Mantzouranis E, Steinberg AD, Schlossman SF. Autoantibody to an immunoregulatory inducer population in patients with juvenile rheumatoid arthritis. J Clin Invest. 1981 Mar; 67(3):753-61.
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  380. Nadler LM, Ritz J, Griffin JD, Todd RF, Reinherz EL, Schlossman SF. Diagnosis and treatment of human leukemias and lymphomas utilizing monoclonal antibodies. Prog Hematol. 1981; 12:187-225.
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  381. Poppema S, Bhan AK, Reinherz EL, McCluskey RT, Schlossman SF. Distribution of T cell subsets in human lymph nodes. J Exp Med. 1981 Jan 1; 153(1):30-41.
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  382. Reinherz EL, Morimoto C, Penta AC, Schlossman SF. Subpopulations of the T4+ inducer T cell subset in man: evidence for an amplifier population preferentially expressing Ia antigen upon activation. J Immunol. 1981 Jan; 126(1):67-70.
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  383. Breard J, Reinherz EL, O'Brien C, Schlossman SF. Delineation of an effector population responsible for natural killing and antibody-dependent cellular cytotoxicity in man. Clin Immunol Immunopathol. 1981 Jan; 18(1):145-50.
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  384. van Agthoven A, Terhorst C, Reinherz E, Schlossman S. Characterization of T cell surface glycoproteins T 1 and T 3 present on all human peripheral T lymphocytes and functionally mature thymocytes. Eur J Immunol. 1981 Jan; 11(1):18-21.
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  385. Morimoto C, Reinherz EL, Schlossman SF, Schur PH, Mills JA, Steinberg AD. Alterations in immunoregulatory T cell subsets in active systemic lupus erythematosus. J Clin Invest. 1980 Nov; 66(5):1171-4.
    View in: PubMed
  386. Reinherz EL, Hussey RE, Schlossman SF. A monoclonal antibody blocking human T cell function. Eur J Immunol. 1980 Oct; 10(10):758-62.
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  387. Bhan AK, Reinherz EL, Poppema S, McCluskey RT, Schlossman SF. Location of T cell and major histocompatibility complex antigens in the human thymus. J Exp Med. 1980 Oct 1; 152(4):771-82.
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  388. Todd RF, Reinherz EL, Schlossman SF. Human macrophage-lymphocyte interaction in proliferation to soluble antigen. I. Specific delection of lymphocyte proliferative activity on macrophage monolayers. Cell Immunol. 1980 Sep 15; 55(1):114-23.
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  389. Mehra V, Mason LH, Rothman W, Reinherz E, Schlossman SF, Bloom BR. Delineation of a human T cell subset responsible for lepromin-induced suppression in leprosy patients. J Immunol. 1980 Sep; 125(3):1183-8.
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  390. Reinherz EL, O'Brien C, Rosenthal P, Schlossman SF. The cellular basis for viral-induced immunodeficiency: analysis by monoclonal antibodies. J Immunol. 1980 Sep; 125(3):1269-74.
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  391. Reinherz EL, Schlossman SF. Current concepts in immunology: Regulation of the immune response--inducer and suppressor T-lymphocyte subsets in human beings. N Engl J Med. 1980 Aug 14; 303(7):370-3.
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  392. Morimoto C, Reinherz EL, Abe T, Homma M, Schlossman SF. Characteristics of anti-T-cell antibodies in systemic lupus erythematosus: evidence for selective reactivity with normal suppressor cells defined by monoclonal antibodies. Clin Immunol Immunopathol. 1980 Aug; 16(4):474-84.
    View in: PubMed
  393. Lipton JM, Reinherz EL, Kudisch M, Jackson PL, Schlossman SF, Nathan DG. Mature bone marrow erythroid burst-forming units do not require T cells for induction of erythropoietin-dependent differentiation. J Exp Med. 1980 Aug 1; 152(2):350-60.
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  394. Terhorst C, van Agthoven A, Reinherz E, Schlossman S. Biochemical analysis of human T lymphocyte differentiation antigens T4 and T5. Science. 1980 Jul 25; 209(4455):520-1.
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  395. Reinherz EL, Weiner HL, Hauser SL, Cohen JA, Distaso JA, Schlossman SF. Loss of suppressor T cells in active multiple sclerosis. Analysis with monoclonal antibodies. N Engl J Med. 1980 Jul 17; 303(3):125-9.
    View in: PubMed
  396. Reinherz EL, Morimoto C, Penta AC, Schlossman SF. Regulation of B cell immunoglobulin secretion by functional subsets of T lymphocytes in man. Eur J Immunol. 1980 Jul; 10(7):570-2.
    View in: PubMed
  397. Nadler LM, Reinherz EL, Weinstein HJ, D'Orsi CJ, Schlossman SF. Heterogeneity of T-cell lymphoblastic malignancies. Blood. 1980 May; 55(5):806-10.
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  398. Reinherz EL, Moretta L, Roper M, Breard JM, Mingari MC, Cooper MD, Schlossman SF. Human T lymphocyte subpopulations defined by Fc receptors and monoclonal antibodies. A comparison. J Exp Med. 1980 Apr 1; 151(4):969-74.
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  399. Reinherz EL, Schlossman SF. The differentiation and function of human T lymphocytes. Cell. 1980 Apr; 19(4):821-7.
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  400. Breard J, Reinherz EL, Kung PC, Goldstein G, Schlossman SF. A monoclonal antibody reactive with human peripheral blood monocytes. J Immunol. 1980 Apr; 124(4):1943-8.
    View in: PubMed
  401. Reinherz EL, Kung PC, Breard JM, Goldstein G, Schlossman SF. T cell requirements for generation of helper factor(s) in man: analysis of the subsets involved. J Immunol. 1980 Apr; 124(4):1883-7.
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  402. Reinherz EL, Kung PC, Goldstein G, Levey RH, Schlossman SF. Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage. Proc Natl Acad Sci U S A. 1980 Mar; 77(3):1588-92.
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  403. Reinherz EL, Kung PC, Goldstein G, Schlossman SF. A monoclonal antibody reactive with the human cytotoxic/suppressor T cell subset previously defined by a heteroantiserum termed TH2. J Immunol. 1980 Mar; 124(3):1301-7.
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  404. Nadler LM, Reinherz EL, Schlossman SF. The T lymphoblastic malignancies. Cancer Chemother Pharmacol. 1980; 4(1):11-5.
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  405. Reinherz EL, Hussey RE, Schlossman SF. Absence of expression of Ia antigen on human cytotoxic T cells. Immunogenetics. 1980; 11(4):421-6.
    View in: PubMed
  406. Reinherz EL, Kung PC, Goldstein G, Schlossman SF. Further characterization of the human inducer T cell subset defined by monoclonal antibody. J Immunol. 1979 Dec; 123(6):2894-6.
    View in: PubMed
  407. Reinherz EL, Kung PC, Pesando JM, Ritz J, Goldstein G, Schlossman SF. Ia determinants on human T-cell subsets defined by monoclonal antibody. Activation stimuli required for expression. J Exp Med. 1979 Dec 1; 150(6):1472-82.
    View in: PubMed
  408. Reinherz EL, Rubinstein A, Geha RS, Strelkauskas AJ, Rosen FS, Schlossman SF. Abnormalities of immunoregulatory T cells in disorders of immune function. N Engl J Med. 1979 Nov 8; 301(19):1018-22.
    View in: PubMed
  409. Kung P, Goldstein G, Reinherz EL, Schlossman SF. Monoclonal antibodies defining distinctive human T cell surface antigens. Science. 1979 Oct 19; 206(4416):347-9.
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  410. Rappeport J, Mihm M, Reinherz E, Lopansri S, Parkman R. Acute graft-versus-host disease in recipients of bone-marrow transplants from identical twin donors. Lancet. 1979 Oct 6; 2(8145):717-20.
    View in: PubMed
  411. Reinherz EL, Kung PC, Goldstein G, Schlossman SF. A monoclonal antibody with selective reactivity with functionally mature human thymocytes and all peripheral human T cells. J Immunol. 1979 Sep; 123(3):1312-7.
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  412. Reinherz EL, Nadler LM, Sallan SE, Schlossman SF. Subset derivation of T-cell acute lymphoblastic leukemia in man. J Clin Invest. 1979 Aug; 64(2):392-7.
    View in: PubMed
  413. Reinherz EL, Kung PC, Goldstein G, Schlossman SF. Separation of functional subsets of human T cells by a monoclonal antibody. Proc Natl Acad Sci U S A. 1979 Aug; 76(8):4061-5.
    View in: PubMed
  414. Reinherz EL, Strelkauskas AJ, O'Brien C, Schlossman SF. Phenotypic and functional distinctions between the TH2+ and JRA+ T cell subsets in man. J Immunol. 1979 Jul; 123(1):83-6.
    View in: PubMed
  415. Reinherz EL, Nadler LM, Rosenthal DS, Moloney WC, Schlossman SF. T-cell-subset characterization of human T-CLL. Blood. 1979 Jun; 53(6):1066-75.
    View in: PubMed
  416. Reinherz EL, Parkman R, Rappeport J, Rosen FS, Schlossman SF. Aberrations of suppressor T cells in human graft-versus-host disease. N Engl J Med. 1979 May 10; 300(19):1061-8.
    View in: PubMed
  417. Reinherz EL, Schlossman SF. Con A-inducible suppression of MLC: evidence for mediation by the TH2 + T cell subset in man. J Immunol. 1979 Apr; 122(4):1335-41.
    View in: PubMed
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