Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

Donald William Kufe, M.D.

TitleProfessor of Medicine
InstitutionDana-Farber Cancer Institute
DepartmentMedicine
AddressDana Farber Cancer Institute
450 Brookline Avenue
Boston MA 02215
Phone617/632-3141
Fax617/632-2934

 Overview 
 overview
The Kufe laboratory identified the human DF3/MUC1 carcinoma-associated protein in the early 1980s. Initial studies demonstrated that MUC1 is aberrantly overexpressed in >90% of human breast cancers. Subsequent work by multiple laboratories showed that MUC1 is expressed at elevated levels by diverse carcinomas and certain hematologic malignancies. Estimates indicate that MUC1 is overexpressed in about 900,000 of the 1.4 million tumors diagnosed each year in the United States.

MUC1 is translated as a single polypeptide that undergoes autocleavage into two subunits (MUC1-N and MUC1-C) that in turn form a stable heterodimer at the apical membrane of normal epithelial cells. Early research on MUC1 focused on the shed MUC1-N mucin component and led to development of the CA15-3 assay to monitor circulating levels of this subunit as a tumor biomarker. Subsequent work then turned to the MUC1-C transmembrane subunit as the potential link between its overexpression and carcinogenesis. Indeed, the MUC1-C cytoplasmic domain was shown to be sufficient to induce transformation.

With transformation and loss of polarity, MUC1-C associates with EGFR, ErbB2 and other receptor tyrosine kinases at the cell membrane. MUC1-C also localizes to the cytoplasm of transformed cells and is targeted to the nucleus and mitochondria. The MUC1-C cytoplasmic domain directly contributes to the regulation of effectors, such as p53, ß-catenin, NF-kappaB and STATs, that have been linked to transformation. The MUC1-C cytoplasmic domain also functions as a substrate for EGFR, MET, Src family members, c-Abl and GSK3ß supporting a role in diverse signaling pathways.

These findings have provided support for a model in which human tumors overexpress MUC1-C to exploit its role in promoting growth and survival. In addition, the overexpression of MUC1-C in a substantial number of human malignancies has established it as a highly attractive target for the development of targeted agents.

Translational research in the Kufe laboratory has been focused on the development of approaches that block MUC1-C subunit function with soluble receptors and antibodies against the MUC1-C extracellular domain. The demonstration that MUC1-C transforming function is dependent on the formation of oligomers has also provided the experimental framework for designing agents, such as cell-penetrating peptides and small molecules, that block its oligomerization. Based on this work, the first-in-man MUC1-C inhibitor, designated GO-203, has entered Phase I evaluation in patients with refractory solid tumors.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Alam M, Ahmad R, Rajabi H, Kharbanda A, Kufe D. MUC1-C Oncoprotein Activates ERK->C/EBPß Signaling and Induction of Aldehyde Dehydrogenase 1A1 in Breast Cancer Cells. J Biol Chem. 2013 Oct 25; 288(43):30892-903.
    View in: PubMed
  2. Stroopinsky D, Rosenblatt J, Ito K, Mills H, Yin L, Rajabi H, Vasir B, Kufe T, Luptakova K, Arnason J, Nardella C, Levine JD, Joyce RM, Galinsky I, Reiter Y, Stone RM, Pandolfi PP, Kufe D, Avigan D. MUC1 Is a Potential Target for the Treatment of Acute Myeloid Leukemia Stem Cells. Cancer Res. 2013 Sep 1; 73(17):5569-79.
    View in: PubMed
  3. Rosenblatt J, Avivi I, Vasir B, Uhl L, Munshi NC, Katz T, Dey BR, Somaiya P, Mills H, Campigotto F, Weller E, Joyce R, Levine JD, Tzachanis D, Richardson P, Laubach J, Raje N, Boussiotis V, Yuan YE, Bisharat L, Held V, Rowe J, Anderson K, Kufe D, Avigan D. Vaccination with Dendritic Cell/Tumor Fusions following Autologous Stem Cell Transplant Induces Immunologic and Clinical Responses in Multiple Myeloma Patients. Clin Cancer Res. 2013 Jul 1; 19(13):3640-8.
    View in: PubMed
  4. Kharbanda A, Rajabi H, Jin C, Raina D, Kufe D. Oncogenic MUC1-C Promotes Tamoxifen Resistance in Human Breast Cancer. Mol Cancer Res. 2013 Jul; 11(7):714-23.
    View in: PubMed
  5. Uchida Y, Raina D, Kharbanda S, Kufe D. Inhibition of the MUC1-C oncoprotein is synergistic with cytotoxic agents in the treatment of breast cancer cells. Cancer Biol Ther. 2013 Feb 1; 14(2):127-34.
    View in: PubMed
  6. Vasir B, Zarwan C, Ahmad R, Crawford KD, Rajabi H, Matsuoka K, Rosenblatt J, Wu Z, Mills H, Kufe D, Avigan D. Induction of antitumor immunity ex vivo using dendritic cells transduced with fowl pox vector expressing MUC1, CEA, and a triad of costimulatory molecules (rF-PANVAC). J Immunother. 2012 Sep; 35(7):555-69.
    View in: PubMed
  7. Jin C, Rajabi H, Pitroda S, Li A, Kharbanda A, Weichselbaum R, Kufe D. Cooperative interaction between the MUC1-C oncoprotein and the Rab31 GTPase in estrogen receptor-positive breast cancer cells. PLoS One. 2012; 7(7):e39432.
    View in: PubMed
  8. Luptakova K, Rosenblatt J, Glotzbecker B, Mills H, Stroopinsky D, Kufe T, Vasir B, Arnason J, Tzachanis D, Zwicker JI, Joyce RM, Levine JD, Anderson KC, Kufe D, Avigan D. Lenalidomide enhances anti-myeloma cellular immunity. Cancer Immunol Immunother. 2013 Jan; 62(1):39-49.
    View in: PubMed
  9. Jin C, Rajabi H, Rodrigo CM, Porco JA, Kufe D. Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein. Oncogene. 2013 Apr 25; 32(17):2179-88.
    View in: PubMed
  10. Avigan D, Rosenblatt J, Kufe D. Dendritic/tumor fusion cells as cancer vaccines. Semin Oncol. 2012 Jun; 39(3):287-95.
    View in: PubMed
  11. Hong DS, Kurzrock R, Supko JG, He X, Naing A, Wheler J, Lawrence D, Eder JP, Meyer CJ, Ferguson DA, Mier J, Konopleva M, Konoplev S, Andreeff M, Kufe D, Lazarus H, Shapiro GI, Dezube BJ. A phase i first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas. Clin Cancer Res. 2012 Jun 15; 18(12):3396-406.
    View in: PubMed
  12. Kufe DW. MUC1-C oncoprotein as a target in breast cancer: activation of signaling pathways and therapeutic approaches. Oncogene. 2013 Feb 28; 32(9):1073-81.
    View in: PubMed
  13. Ahmad R, Alam M, Rajabi H, Kufe D. The MUC1-C oncoprotein binds to the BH3 domain of the pro-apoptotic BAX protein and blocks BAX function. J Biol Chem. 2012 Jun 15; 287(25):20866-75.
    View in: PubMed
  14. Rajabi H, Ahmad R, Jin C, Joshi MD, Guha M, Alam M, Kharbanda S, Kufe D. MUC1-C oncoprotein confers androgen-independent growth of human prostate cancer cells. Prostate. 2012 Nov; 72(15):1659-68.
    View in: PubMed
  15. Rajabi H, Ahmad R, Jin C, Kosugi M, Alam M, Joshi MD, Kufe D. MUC1-C oncoprotein induces TCF7L2 transcription factor activation and promotes cyclin D1 expression in human breast cancer cells. J Biol Chem. 2012 Mar 23; 287(13):10703-13.
    View in: PubMed
  16. Raina D, Ahmad R, Rajabi H, Panchamoorthy G, Kharbanda S, Kufe D. Targeting cysteine-mediated dimerization of the MUC1-C oncoprotein in human cancer cells. Int J Oncol. 2012 May; 40(5):1643-9.
    View in: PubMed
  17. Panchamoorthy G, Rehan H, Kharbanda A, Ahmad R, Kufe D. A monoclonal antibody against the oncogenic mucin 1 cytoplasmic domain. Hybridoma (Larchmt). 2011 Dec; 30(6):531-5.
    View in: PubMed
  18. Kosugi M, Ahmad R, Alam M, Uchida Y, Kufe D. MUC1-C oncoprotein regulates glycolysis and pyruvate kinase M2 activity in cancer cells. PLoS One. 2011; 6(11):e28234.
    View in: PubMed
  19. Yin L, Kosugi M, Kufe D. Inhibition of the MUC1-C oncoprotein induces multiple myeloma cell death by down-regulating TIGAR expression and depleting NADPH. Blood. 2012 Jan 19; 119(3):810-6.
    View in: PubMed
  20. Sakakibara K, Saito N, Sato T, Suzuki A, Hasegawa Y, Friedman JM, Kufe DW, Vonhoff DD, Iwami T, Kawabe T. CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity. Blood. 2011 Oct 6; 118(14):3922-31.
    View in: PubMed
  21. Mine N, Yamamoto S, Saito N, Yamazaki S, Suda C, Ishigaki M, Kufe DW, Von Hoff DD, Kawabe T. CBP501-calmodulin binding contributes to sensitizing tumor cells to cisplatin and bleomycin. Mol Cancer Ther. 2011 Oct; 10(10):1929-38.
    View in: PubMed
  22. Rosenblatt J, Glotzbecker B, Mills H, Vasir B, Tzachanis D, Levine JD, Joyce RM, Wellenstein K, Keefe W, Schickler M, Rotem-Yehudar R, Kufe D, Avigan D. PD-1 blockade by CT-011, anti-PD-1 antibody, enhances ex vivo T-cell responses to autologous dendritic cell/myeloma fusion vaccine. J Immunother. 2011 Jun; 34(5):409-18.
    View in: PubMed
  23. Yin L, Wu Z, Avigan D, Rosenblatt J, Stone R, Kharbanda S, Kufe D. MUC1-C oncoprotein suppresses reactive oxygen species-induced terminal differentiation of acute myelogenous leukemia cells. Blood. 2011 May 5; 117(18):4863-70.
    View in: PubMed
  24. Raina D, Kosugi M, Ahmad R, Panchamoorthy G, Rajabi H, Alam M, Shimamura T, Shapiro GI, Supko J, Kharbanda S, Kufe D. Dependence on the MUC1-C oncoprotein in non-small cell lung cancer cells. Mol Cancer Ther. 2011 May; 10(5):806-16.
    View in: PubMed
  25. Zhou Y, Rajabi H, Kufe D. Mucin 1 C-terminal subunit oncoprotein is a target for small-molecule inhibitors. Mol Pharmacol. 2011 May; 79(5):886-93.
    View in: PubMed
  26. Ahmad R, Rajabi H, Kosugi M, Joshi MD, Alam M, Vasir B, Kawano T, Kharbanda S, Kufe D. MUC1-C oncoprotein promotes STAT3 activation in an autoinductive regulatory loop. Sci Signal. 2011; 4(160):ra9.
    View in: PubMed
  27. Rajabi H, Joshi MD, Jin C, Ahmad R, Kufe D. Androgen receptor regulates expression of the MUC1-C oncoprotein in human prostate cancer cells. Prostate. 2011 Sep; 71(12):1299-308.
    View in: PubMed
  28. Shapiro GI, Tibes R, Gordon MS, Wong BY, Eder JP, Borad MJ, Mendelson DS, Vogelzang NJ, Bastos BR, Weiss GJ, Fernandez C, Sutherland W, Sato H, Pierceall WE, Weaver D, Slough S, Wasserman E, Kufe DW, Von Hoff D, Kawabe T, Sharma S. Phase I studies of CBP501, a G2 checkpoint abrogator, as monotherapy and in combination with cisplatin in patients with advanced solid tumors. Clin Cancer Res. 2011 May 15; 17(10):3431-42.
    View in: PubMed
  29. Yin L, Kufe D. MUC1-C Oncoprotein Blocks Terminal Differentiation of Chronic Myelogenous Leukemia Cells by a ROS-Mediated Mechanism. Genes Cancer. 2011 Jan; 2(1):56-64.
    View in: PubMed
  30. Rosenblatt J, Vasir B, Uhl L, Blotta S, Macnamara C, Somaiya P, Wu Z, Joyce R, Levine JD, Dombagoda D, Yuan YE, Francoeur K, Fitzgerald D, Richardson P, Weller E, Anderson K, Kufe D, Munshi N, Avigan D. Vaccination with dendritic cell/tumor fusion cells results in cellular and humoral antitumor immune responses in patients with multiple myeloma. Blood. 2011 Jan 13; 117(2):393-402.
    View in: PubMed
  31. Yin L, Ahmad R, Kosugi M, Kawano T, Avigan D, Stone R, Kharbanda S, Kufe D. Terminal differentiation of chronic myelogenous leukemia cells is induced by targeting of the MUC1-C oncoprotein. Cancer Biol Ther. 2010 Sep; 10(5):483-91.
    View in: PubMed
  32. Kufe D. Oncogenic function of the MUC1 receptor subunit in gene regulation. Oncogene. 2010 Oct 21; 29(42):5663-6.
    View in: PubMed
  33. Jin C, Rajabi H, Kufe D. miR-1226 targets expression of the mucin 1 oncoprotein and induces cell death. Int J Oncol. 2010 Jul; 37(1):61-9.
    View in: PubMed
  34. Ahmad R, Liu S, Weisberg E, Nelson E, Galinsky I, Meyer C, Kufe D, Kharbanda S, Stone R. Combining the FLT3 inhibitor PKC412 and the triterpenoid CDDO-Me synergistically induces apoptosis in acute myeloid leukemia with the internal tandem duplication mutation. Mol Cancer Res. 2010 Jul; 8(7):986-93.
    View in: PubMed
  35. MacDermed DM, Khodarev NN, Pitroda SP, Edwards DC, Pelizzari CA, Huang L, Kufe DW, Weichselbaum RR. MUC1-associated proliferation signature predicts outcomes in lung adenocarcinoma patients. BMC Med Genomics. 2010; 3:16.
    View in: PubMed
  36. Yin L, Ahmad R, Kosugi M, Kufe T, Vasir B, Avigan D, Kharbanda S, Kufe D. Survival of human multiple myeloma cells is dependent on MUC1 C-terminal transmembrane subunit oncoprotein function. Mol Pharmacol. 2010 Aug; 78(2):166-74.
    View in: PubMed
  37. Meng Y, Mauceri HJ, Khodarev NN, Darga TE, Pitroda SP, Beckett MA, Kufe DW, Weichselbaum RR. Ad.Egr-TNF and local ionizing radiation suppress metastases by interferon-beta-dependent activation of antigen-specific CD8+ T cells. Mol Ther. 2010 May; 18(5):912-20.
    View in: PubMed
  38. Huang L, Liao X, Beckett M, Li Y, Khanna KK, Wang Z, Kharbanda S, Weichselbaum R, Kufe D. MUC1-C Oncoprotein Interacts Directly with ATM and Promotes the DNA Damage Response to Ionizing Radiation. Genes Cancer. 2010 Mar; 1(3):239-250.
    View in: PubMed
  39. Rosenblatt J, Wu Z, Vasir B, Zarwan C, Stone R, Mills H, Friedman T, Konstantinopoulos PA, Spentzos D, Ghebremichael M, Stevenson K, Neuberg D, Levine JD, Joyce R, Tzachanis D, Boussiotis V, Kufe D, Avigan D. Generation of tumor-specific T lymphocytes using dendritic cell/tumor fusions and anti-CD3/CD28. J Immunother. 2010 Feb-Mar; 33(2):155-66.
    View in: PubMed
  40. Rosenblatt J, Bissonnette A, Ahmad R, Wu Z, Vasir B, Stevenson K, Zarwan C, Keefe W, Glotzbecker B, Mills H, Joyce R, Levine JD, Tzachanis D, Boussiotis V, Kufe D, Avigan D. Immunomodulatory effects of vitamin D: implications for GVHD. Bone Marrow Transplant. 2010 Sep; 45(9):1463-8.
    View in: PubMed
  41. Rajabi H, Jin C, Ahmad R, McClary C, Joshi MD, Kufe D. MUCIN 1 ONCOPROTEIN EXPRESSION IS SUPPRESSED BY THE miR-125b ONCOMIR. Genes Cancer. 2010 Jan 1; 1(1):62-68.
    View in: PubMed
  42. Kufe DW. Mucins in cancer: function, prognosis and therapy. Nat Rev Cancer. 2009 Dec; 9(12):874-85.
    View in: PubMed
  43. Khodarev N, Ahmad R, Rajabi H, Pitroda S, Kufe T, McClary C, Joshi MD, MacDermed D, Weichselbaum R, Kufe D. Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer. Oncogene. 2010 Feb 11; 29(6):920-9.
    View in: PubMed
  44. Joshi MD, Ahmad R, Yin L, Raina D, Rajabi H, Bubley G, Kharbanda S, Kufe D. MUC1 oncoprotein is a druggable target in human prostate cancer cells. Mol Cancer Ther. 2009 Nov; 8(11):3056-65.
    View in: PubMed
  45. Ahmad R, Raina D, Joshi MD, Kawano T, Ren J, Kharbanda S, Kufe D. MUC1-C oncoprotein functions as a direct activator of the nuclear factor-kappaB p65 transcription factor. Cancer Res. 2009 Sep 1; 69(17):7013-21.
    View in: PubMed
  46. Kufe DW. Functional targeting of the MUC1 oncogene in human cancers. Cancer Biol Ther. 2009 Jul; 8(13):1197-203.
    View in: PubMed
  47. Raina D, Ahmad R, Joshi MD, Yin L, Wu Z, Kawano T, Vasir B, Avigan D, Kharbanda S, Kufe D. Direct targeting of the mucin 1 oncoprotein blocks survival and tumorigenicity of human breast carcinoma cells. Cancer Res. 2009 Jun 15; 69(12):5133-41.
    View in: PubMed
  48. Yin L, Kharbanda S, Kufe D. MUC1 oncoprotein promotes autophagy in a survival response to glucose deprivation. Int J Oncol. 2009 Jun; 34(6):1691-9.
    View in: PubMed
  49. Weichselbaum RR, Kufe D. Translation of the radio- and chemo-inducible TNFerade vector to the treatment of human cancers. Cancer Gene Ther. 2009 Aug; 16(8):609-19.
    View in: PubMed
  50. Khodarev NN, Pitroda SP, Beckett MA, MacDermed DM, Huang L, Kufe DW, Weichselbaum RR. MUC1-induced transcriptional programs associated with tumorigenesis predict outcome in breast and lung cancer. Cancer Res. 2009 Apr 1; 69(7):2833-7.
    View in: PubMed
  51. Pitroda SP, Khodarev NN, Beckett MA, Kufe DW, Weichselbaum RR. MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment. Proc Natl Acad Sci U S A. 2009 Apr 7; 106(14):5837-41.
    View in: PubMed
  52. Raina D, Ahmad R, Chen D, Kumar S, Kharbanda S, Kufe D. MUC1 oncoprotein suppresses activation of the ARF-MDM2-p53 pathway. Cancer Biol Ther. 2008 Dec; 7(12):1959-67.
    View in: PubMed
  53. Mauceri HJ, Beckett MA, Liang H, Sutton HG, Pitroda S, Galka E, Efimova E, Darga T, Khodarev NN, King CR, Posner MC, Hellman S, Kufe DW, Weichselbaum RR. Translational strategies exploiting TNF-alpha that sensitize tumors to radiation therapy. Cancer Gene Ther. 2009 Apr; 16(4):373-81.
    View in: PubMed
  54. Agata N, Ahmad R, Kawano T, Raina D, Kharbanda S, Kufe D. MUC1 oncoprotein blocks death receptor-mediated apoptosis by inhibiting recruitment of caspase-8. Cancer Res. 2008 Aug 1; 68(15):6136-44.
    View in: PubMed
  55. Kawano T, Ahmad R, Nogi H, Agata N, Anderson K, Kufe D. MUC1 oncoprotein promotes growth and survival of human multiple myeloma cells. Int J Oncol. 2008 Jul; 33(1):153-9.
    View in: PubMed
  56. Vasir B, Wu Z, Crawford K, Rosenblatt J, Zarwan C, Bissonnette A, Kufe D, Avigan D. Fusions of dendritic cells with breast carcinoma stimulate the expansion of regulatory T cells while concomitant exposure to IL-12, CpG oligodeoxynucleotides, and anti-CD3/CD28 promotes the expansion of activated tumor reactive cells. J Immunol. 2008 Jul 1; 181(1):808-21.
    View in: PubMed
  57. Ahmad R, Raina D, Meyer C, Kufe D. Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3. Cancer Res. 2008 Apr 15; 68(8):2920-6.
    View in: PubMed
  58. Kufe DW. Targeting the human MUC1 oncoprotein: a tale of two proteins. Cancer Biol Ther. 2008 Jan; 7(1):81-4.
    View in: PubMed
  59. Kawano T, Ito M, Raina D, Wu Z, Rosenblatt J, Avigan D, Stone R, Kufe D. MUC1 oncoprotein regulates Bcr-Abl stability and pathogenesis in chronic myelogenous leukemia cells. Cancer Res. 2007 Dec 15; 67(24):11576-84.
    View in: PubMed
  60. Katdare M, Efimova EV, Labay E, Khodarev NN, Darga TE, Garofalo M, Nakamura S, Kufe DW, Posner MC, Weichselbaum RR. Diverse TNFalpha-induced death pathways are enhanced by inhibition of NF-kappaB. Int J Oncol. 2007 Dec; 31(6):1519-28.
    View in: PubMed
  61. Ahmad R, Raina D, Trivedi V, Ren J, Rajabi H, Kharbanda S, Kufe D. MUC1 oncoprotein activates the IkappaB kinase beta complex and constitutive NF-kappaB signalling. Nat Cell Biol. 2007 Dec; 9(12):1419-27.
    View in: PubMed
  62. Avigan DE, Vasir B, George DJ, Oh WK, Atkins MB, McDermott DF, Kantoff PW, Figlin RA, Vasconcelles MJ, Xu Y, Kufe D, Bukowski RM. Phase I/II study of vaccination with electrofused allogeneic dendritic cells/autologous tumor-derived cells in patients with stage IV renal cell carcinoma. J Immunother. 2007 Oct; 30(7):749-61.
    View in: PubMed
  63. Ramasamy S, Duraisamy S, Barbashov S, Kawano T, Kharbanda S, Kufe D. The MUC1 and galectin-3 oncoproteins function in a microRNA-dependent regulatory loop. Mol Cell. 2007 Sep 21; 27(6):992-1004.
    View in: PubMed
  64. Duraisamy S, Kufe T, Ramasamy S, Kufe D. Evolution of the human MUC1 oncoprotein. Int J Oncol. 2007 Sep; 31(3):671-7.
    View in: PubMed
  65. Yamini B, Yu X, Dolan ME, Wu MH, Darga TE, Kufe DW, Weichselbaum RR. Inhibition of nuclear factor-kappaB activity by temozolomide involves O6-methylguanine induced inhibition of p65 DNA binding. Cancer Res. 2007 Jul 15; 67(14):6889-98.
    View in: PubMed
  66. Imam SZ, Indig FE, Cheng WH, Saxena SP, Stevnsner T, Kufe D, Bohr VA. Cockayne syndrome protein B interacts with and is phosphorylated by c-Abl tyrosine kinase. Nucleic Acids Res. 2007; 35(15):4941-51.
    View in: PubMed
  67. Leng Y, Cao C, Ren J, Huang L, Chen D, Ito M, Kufe D. Nuclear import of the MUC1-C oncoprotein is mediated by nucleoporin Nup62. J Biol Chem. 2007 Jul 6; 282(27):19321-30.
    View in: PubMed
  68. Wei X, Xu H, Kufe D. Human mucin 1 oncoprotein represses transcription of the p53 tumor suppressor gene. Cancer Res. 2007 Feb 15; 67(4):1853-8.
    View in: PubMed
  69. Lerma EI, Nguyen VA, Wang T, Tipping A, Melo JV, Kufe D, Austin DJ, Deisseroth A. Novel compounds with antiproliferative activity against imatinib-resistant cell lines. Mol Cancer Ther. 2007 Feb; 6(2):655-66.
    View in: PubMed
  70. Sha SK, Sato T, Kobayashi H, Ishigaki M, Yamamoto S, Sato H, Takada A, Nakajyo S, Mochizuki Y, Friedman JM, Cheng FC, Okura T, Kimura R, Kufe DW, Vonhoff DD, Kawabe T. Cell cycle phenotype-based optimization of G2-abrogating peptides yields CBP501 with a unique mechanism of action at the G2 checkpoint. Mol Cancer Ther. 2007 Jan; 6(1):147-53.
    View in: PubMed
  71. Yin L, Kharbanda S, Kufe D. Mucin 1 oncoprotein blocks hypoxia-inducible factor 1alpha activation in a survival response to hypoxia. J Biol Chem. 2007 Jan 5; 282(1):257-66.
    View in: PubMed
  72. Ren J, Raina D, Chen W, Li G, Huang L, Kufe D. MUC1 oncoprotein functions in activation of fibroblast growth factor receptor signaling. Mol Cancer Res. 2006 Nov; 4(11):873-83.
    View in: PubMed
  73. Ahmad R, Raina D, Meyer C, Kharbanda S, Kufe D. Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179. J Biol Chem. 2006 Nov 24; 281(47):35764-9.
    View in: PubMed
  74. Raina D, Ahmad R, Kumar S, Ren J, Yoshida K, Kharbanda S, Kufe D. MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage. EMBO J. 2006 Aug 23; 25(16):3774-83.
    View in: PubMed
  75. Kawano T, Agata N, Kharbanda S, Avigan D, Kufe D. A novel isocoumarin derivative induces mitotic phase arrest and apoptosis of human multiple myeloma cells. Cancer Chemother Pharmacol. 2007 Feb; 59(3):329-35.
    View in: PubMed
  76. Duraisamy S, Ramasamy S, Kharbanda S, Kufe D. Distinct evolution of the human carcinoma-associated transmembrane mucins, MUC1, MUC4 AND MUC16. Gene. 2006 May 24; 373:28-34.
    View in: PubMed
  77. Wei X, Xu H, Kufe D. MUC1 oncoprotein stabilizes and activates estrogen receptor alpha. Mol Cell. 2006 Jan 20; 21(2):295-305.
    View in: PubMed
  78. Ren J, Bharti A, Raina D, Chen W, Ahmad R, Kufe D. MUC1 oncoprotein is targeted to mitochondria by heregulin-induced activation of c-Src and the molecular chaperone HSP90. Oncogene. 2006 Jan 5; 25(1):20-31.
    View in: PubMed
  79. Mezhir JJ, Smith KD, Posner MC, Senzer N, Yamini B, Kufe DW, Weichselbaum RR. Ionizing radiation: a genetic switch for cancer therapy. Cancer Gene Ther. 2006 Jan 1; 13(1):1-6.
    View in: PubMed
  80. Huang L, Chen D, Liu D, Yin L, Kharbanda S, Kufe D. MUC1 oncoprotein blocks glycogen synthase kinase 3beta-mediated phosphorylation and degradation of beta-catenin. Cancer Res. 2005 Nov 15; 65(22):10413-22.
    View in: PubMed
  81. Mezhir JJ, Schmidt H, Yamini B, Senzer NN, Posner MC, Kufe DW, Weichselbaum RR. Chemo-inducible gene therapy. Anticancer Drugs. 2005 Nov; 16(10):1053-8.
    View in: PubMed
  82. Agata N, Nogi H, Bamberg M, Milhollen M, Pu M, Weitman S, Kharbanda S, Kufe D. The angiogenesis inhibitor NM-3 is active against human NSCLC xenografts alone and in combination with docetaxel. Cancer Chemother Pharmacol. 2005 Dec; 56(6):610-4.
    View in: PubMed
  83. Vasir B, Borges V, Wu Z, Grosman D, Rosenblatt J, Irie M, Anderson K, Kufe D, Avigan D. Fusion of dendritic cells with multiple myeloma cells results in maturation and enhanced antigen presentation. Br J Haematol. 2005 Jun; 129(5):687-700.
    View in: PubMed
  84. Murphy KT, Wardak A, Beckett MA, Lopez CA, Mehta N, Kimchi E, Salloum RM, Jaskowiak NT, Posner MC, Ohno T, Kufe DW, Weichselbaum RR, Mauceri HJ. Forphenicinol enhances the antitumor effects of cyclophosphamide in a model of squamous cell carcinoma. Cancer Chemother Pharmacol. 2005 Sep; 56(3):317-21.
    View in: PubMed
  85. Ikeda T, Kimura F, Nakata Y, Sato K, Ogura K, Motoyoshi K, Sporn M, Kufe D. Triterpenoid CDDO-Im downregulates PML/RARalpha expression in acute promyelocytic leukemia cells. Cell Death Differ. 2005 May; 12(5):523-31.
    View in: PubMed
  86. Rosenblatt J, Kufe D, Avigan D. Dendritic cell fusion vaccines for cancer immunotherapy. Expert Opin Biol Ther. 2005 May; 5(5):703-15.
    View in: PubMed
  87. Cao C, Li Y, Leng Y, Li P, Ma Q, Kufe D. Ubiquitination and degradation of the Arg tyrosine kinase is regulated by oxidative stress. Oncogene. 2005 Apr 7; 24(15):2433-40.
    View in: PubMed
  88. Homma S, Kikuchi T, Ishiji N, Ochiai K, Takeyama H, Saotome H, Sagawa Y, Hara E, Kufe D, Ryan JL, Ohno T, Toda G. Cancer immunotherapy by fusions of dendritic and tumour cells and rh-IL-12. Eur J Clin Invest. 2005 Apr; 35(4):279-86.
    View in: PubMed
  89. Yoshida K, Yamaguchi T, Natsume T, Kufe D, Miki Y. JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. Nat Cell Biol. 2005 Mar; 7(3):278-85.
    View in: PubMed
  90. Vasir B, Avigan D, Wu Z, Crawford K, Turnquist S, Ren J, Kufe D. Dendritic cells induce MUC1 expression and polarization on human T cells by an IL-7-dependent mechanism. J Immunol. 2005 Feb 15; 174(4):2376-86.
    View in: PubMed
  91. Wei X, Xu H, Kufe D. Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. Cancer Cell. 2005 Feb; 7(2):167-78.
    View in: PubMed
  92. Raina D, Pandey P, Ahmad R, Bharti A, Ren J, Kharbanda S, Weichselbaum R, Kufe D. c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage. J Biol Chem. 2005 Mar 25; 280(12):11147-51.
    View in: PubMed
  93. Agata N, Nogi H, Milhollen M, Kharbanda S, Kufe D. 2-(8-Hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-yl)propionic acid, a small molecule isocoumarin, potentiates dexamethasone-induced apoptosis of human multiple myeloma cells. Cancer Res. 2004 Dec 1; 64(23):8512-6.
    View in: PubMed
  94. Gong J, Koido S, Kato Y, Tanaka Y, Chen D, Jonas A, Galinsky I, DeAngelo D, Avigan D, Kufe D, Stone R. Induction of anti-leukemic cytotoxic T lymphocytes by fusion of patient-derived dendritic cells with autologous myeloblasts. Leuk Res. 2004 Dec; 28(12):1303-12.
    View in: PubMed
  95. Kikuchi T, Akasaki Y, Abe T, Fukuda T, Saotome H, Ryan JL, Kufe DW, Ohno T. Vaccination of glioma patients with fusions of dendritic and glioma cells and recombinant human interleukin 12. J Immunother. 2004 Nov-Dec; 27(6):452-9.
    View in: PubMed
  96. Yamini B, Yu X, Gillespie GY, Kufe DW, Weichselbaum RR. Transcriptional targeting of adenovirally delivered tumor necrosis factor alpha by temozolomide in experimental glioblastoma. Cancer Res. 2004 Sep 15; 64(18):6381-4.
    View in: PubMed
  97. Mundt AJ, Vijayakumar S, Nemunaitis J, Sandler A, Schwartz H, Hanna N, Peabody T, Senzer N, Chu K, Rasmussen CS, Kessler PD, Rasmussen HS, Warso M, Kufe DW, Gupta TD, Weichselbaum RR. A Phase I trial of TNFerade biologic in patients with soft tissue sarcoma in the extremities. Clin Cancer Res. 2004 Sep 1; 10(17):5747-53.
    View in: PubMed
  98. Lopez CA, Kimchi ET, Mauceri HJ, Park JO, Mehta N, Murphy KT, Beckett MA, Hellman S, Posner MC, Kufe DW, Weichselbaum RR. Chemoinducible gene therapy: a strategy to enhance doxorubicin antitumor activity. Mol Cancer Ther. 2004 Sep; 3(9):1167-75.
    View in: PubMed
  99. Irie M, Homma S, Komita H, Zeniya M, Kufe D, Ohno T, Toda G. Inhibition of spontaneous development of liver tumors by inoculation with dendritic cells loaded with hepatocellular carcinoma cells in C3H/HeNCRJ mice. Int J Cancer. 2004 Aug 20; 111(2):238-45.
    View in: PubMed
  100. Yin L, Huang L, Kufe D. MUC1 oncoprotein activates the FOXO3a transcription factor in a survival response to oxidative stress. J Biol Chem. 2004 Oct 29; 279(44):45721-7.
    View in: PubMed
  101. Avigan D, Vasir B, Gong J, Borges V, Wu Z, Uhl L, Atkins M, Mier J, McDermott D, Smith T, Giallambardo N, Stone C, Schadt K, Dolgoff J, Tetreault JC, Villarroel M, Kufe D. Fusion cell vaccination of patients with metastatic breast and renal cancer induces immunological and clinical responses. Clin Cancer Res. 2004 Jul 15; 10(14):4699-708.
    View in: PubMed
  102. Raje N, Hideshima T, Davies FE, Chauhan D, Treon SP, Young G, Tai YT, Avigan D, Gong J, Schlossman RL, Richardson P, Kufe DW, Anderson KC. Tumour cell/dendritic cell fusions as a vaccination strategy for multiple myeloma. Br J Haematol. 2004 May; 125(3):343-52.
    View in: PubMed
  103. Iinuma T, Homma S, Noda T, Kufe D, Ohno T, Toda G. Prevention of gastrointestinal tumors based on adenomatous polyposis coli gene mutation by dendritic cell vaccine. J Clin Invest. 2004 May; 113(9):1307-17.
    View in: PubMed
  104. Nakamura M, Kikuchi T, Kufe DW, Ohno T. Antitumor effects of fusions composed of dendritic cells and fibroblasts transfected with genomic DNA from tumor cells. Cancer Immunol Immunother. 2004 Aug; 53(8):690-6.
    View in: PubMed
  105. Li Q, Ren J, Kufe D. Interaction of human MUC1 and beta-catenin is regulated by Lck and ZAP-70 in activated Jurkat T cells. Biochem Biophys Res Commun. 2004 Mar 5; 315(2):471-6.
    View in: PubMed
  106. Raina D, Kharbanda S, Kufe D. The MUC1 oncoprotein activates the anti-apoptotic phosphoinositide 3-kinase/Akt and Bcl-xL pathways in rat 3Y1 fibroblasts. J Biol Chem. 2004 May 14; 279(20):20607-12.
    View in: PubMed
  107. Ren J, Agata N, Chen D, Li Y, Yu WH, Huang L, Raina D, Chen W, Kharbanda S, Kufe D. Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents. Cancer Cell. 2004 Feb; 5(2):163-75.
    View in: PubMed
  108. Senzer N, Mani S, Rosemurgy A, Nemunaitis J, Cunningham C, Guha C, Bayol N, Gillen M, Chu K, Rasmussen C, Rasmussen H, Kufe D, Weichselbaum R, Hanna N. TNFerade biologic, an adenovector with a radiation-inducible promoter, carrying the human tumor necrosis factor alpha gene: a phase I study in patients with solid tumors. J Clin Oncol. 2004 Feb 15; 22(4):592-601.
    View in: PubMed
  109. Ikeda T, Nakata Y, Kimura F, Sato K, Anderson K, Motoyoshi K, Sporn M, Kufe D. Induction of redox imbalance and apoptosis in multiple myeloma cells by the novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid. Mol Cancer Ther. 2004 Jan; 3(1):39-45.
    View in: PubMed
  110. Supko JG, Eder JP, Ryan DP, Seiden MV, Lynch TJ, Amrein PC, Kufe DW, Clark JW. Phase I clinical trial and pharmacokinetic study of the spicamycin analog KRN5500 administered as a 1-hour intravenous infusion for five consecutive days to patients with refractory solid tumors. Clin Cancer Res. 2003 Nov 1; 9(14):5178-86.
    View in: PubMed
  111. Huang L, Ren J, Chen D, Li Y, Kharbanda S, Kufe D. MUC1 cytoplasmic domain coactivates Wnt target gene transcription and confers transformation. Cancer Biol Ther. 2003 Nov-Dec; 2(6):702-6.
    View in: PubMed
  112. Takeda A, Homma S, Okamoto T, Kufe D, Ohno T. Immature dendritic cell/tumor cell fusions induce potent antitumour immunity. Eur J Clin Invest. 2003 Oct; 33(10):897-904.
    View in: PubMed
  113. Cao C, Leng Y, Liu X, Yi Y, Li P, Kufe D. Catalase is regulated by ubiquitination and proteosomal degradation. Role of the c-Abl and Arg tyrosine kinases. Biochemistry. 2003 Sep 9; 42(35):10348-53.
    View in: PubMed
  114. Li Y, Liu D, Chen D, Kharbanda S, Kufe D. Human DF3/MUC1 carcinoma-associated protein functions as an oncogene. Oncogene. 2003 Sep 4; 22(38):6107-10.
    View in: PubMed
  115. Cheng WH, von Kobbe C, Opresko PL, Fields KM, Ren J, Kufe D, Bohr VA. Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution. Mol Cell Biol. 2003 Sep; 23(18):6385-95.
    View in: PubMed
  116. Ikeda T, Sporn M, Honda T, Gribble GW, Kufe D. The novel triterpenoid CDDO and its derivatives induce apoptosis by disruption of intracellular redox balance. Cancer Res. 2003 Sep 1; 63(17):5551-8.
    View in: PubMed
  117. Li Y, Yu WH, Ren J, Chen W, Huang L, Kharbanda S, Loda M, Kufe D. Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein. Mol Cancer Res. 2003 Aug; 1(10):765-75.
    View in: PubMed
  118. Cao C, Leng Y, Huang W, Liu X, Kufe D. Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine kinases. J Biol Chem. 2003 Oct 10; 278(41):39609-14.
    View in: PubMed
  119. Kufe D, Weichselbaum R. Radiation therapy: activation for gene transcription and the development of genetic radiotherapy-therapeutic strategies in oncology. Cancer Biol Ther. 2003 Jul-Aug; 2(4):326-9.
    View in: PubMed
  120. Yin L, Li Y, Ren J, Kuwahara H, Kufe D. Human MUC1 carcinoma antigen regulates intracellular oxidant levels and the apoptotic response to oxidative stress. J Biol Chem. 2003 Sep 12; 278(37):35458-64.
    View in: PubMed
  121. Chen D, Xia J, Tanaka Y, Chen H, Koido S, Wernet O, Mukherjee P, Gendler SJ, Kufe D, Gong J. Immunotherapy of spontaneous mammary carcinoma with fusions of dendritic cells and mucin 1-positive carcinoma cells. Immunology. 2003 Jun; 109(2):300-7.
    View in: PubMed
  122. Cao C, Leng Y, Kufe D. Catalase activity is regulated by c-Abl and Arg in the oxidative stress response. J Biol Chem. 2003 Aug 8; 278(32):29667-75.
    View in: PubMed
  123. Yoshida K, Wang HG, Miki Y, Kufe D. Protein kinase Cdelta is responsible for constitutive and DNA damage-induced phosphorylation of Rad9. EMBO J. 2003 Mar 17; 22(6):1431-41.
    View in: PubMed
  124. Li Y, Chen W, Ren J, Yu WH, Li Q, Yoshida K, Kufe D. DF3/MUC1 signaling in multiple myeloma cells is regulated by interleukin-7. Cancer Biol Ther. 2003 Mar-Apr; 2(2):187-93.
    View in: PubMed
  125. Cao C, Leng Y, Li C, Kufe D. Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response. J Biol Chem. 2003 Apr 11; 278(15):12961-7.
    View in: PubMed
  126. Gupta VK, Park JO, Kurihara T, Koons A, Mauceri HJ, Jaskowiak NT, Kufe DW, Weichselbaum RR, Posner MC. Selective gene expression using a DF3/MUC1 promoter in a human esophageal adenocarcinoma model. Gene Ther. 2003 Feb; 10(3):206-12.
    View in: PubMed
  127. Kumar S, Mishra N, Raina D, Saxena S, Kufe D. Abrogation of the cell death response to oxidative stress by the c-Abl tyrosine kinase inhibitor STI571. Mol Pharmacol. 2003 Feb; 63(2):276-82.
    View in: PubMed
  128. Homma S, Matai K, Irie M, Ohno T, Kufe D, Toda G. Immunotherapy using fusions of autologous dendritic cells and tumor cells showed effective clinical response in a patient with advanced gastric carcinoma. J Gastroenterol. 2003; 38(10):989-94.
    View in: PubMed
  129. Weichselbaum RR, Kufe DW, Hellman S, Rasmussen HS, King CR, Fischer PH, Mauceri HJ. Radiation-induced tumour necrosis factor-alpha expression: clinical application of transcriptional and physical targeting of gene therapy. Lancet Oncol. 2002 Nov; 3(11):665-71.
    View in: PubMed
  130. Ren X, Cao C, Zhu L, Yoshida K, Kharbanda S, Weichselbaum R, Kufe D. Lyn tyrosine kinase inhibits nuclear export of the p53 tumor suppressor. Cancer Biol Ther. 2002 Nov-Dec; 1(6):703-8.
    View in: PubMed
  131. Borges VF, Kufe D, Avigan DE. Update on cancer vaccines. Curr Opin Gastroenterol. 2002 Nov; 18(6):723-31.
    View in: PubMed
  132. Yoshida K, Miki Y, Kufe D. Activation of SAPK/JNK signaling by protein kinase Cdelta in response to DNA damage. J Biol Chem. 2002 Dec 13; 277(50):48372-8.
    View in: PubMed
  133. Mauceri HJ, Seetharam S, Beckett MA, Schumm LP, Koons A, Gupta VK, Park JO, Manan A, Lee JY, Montag AG, Kufe DW, Weichselbaum RR. Angiostatin potentiates cyclophosphamide treatment of metastatic disease. Cancer Chemother Pharmacol. 2002 Nov; 50(5):412-8.
    View in: PubMed
  134. Eder JP, Supko JG, Clark JW, Puchalski TA, Garcia-Carbonero R, Ryan DP, Shulman LN, Proper J, Kirvan M, Rattner B, Connors S, Keogan MT, Janicek MJ, Fogler WE, Schnipper L, Kinchla N, Sidor C, Phillips E, Folkman J, Kufe DW. Phase I clinical trial of recombinant human endostatin administered as a short intravenous infusion repeated daily. J Clin Oncol. 2002 Sep 15; 20(18):3772-84.
    View in: PubMed
  135. Park JO, Lopez CA, Gupta VK, Brown CK, Mauceri HJ, Darga TE, Manan A, Hellman S, Posner MC, Kufe DW, Weichselbaum RR. Transcriptional control of viral gene therapy by cisplatin. J Clin Invest. 2002 Aug; 110(3):403-10.
    View in: PubMed
  136. Ren J, Datta R, Shioya H, Li Y, Oki E, Biedermann V, Bharti A, Kufe D. p73beta is regulated by protein kinase Cdelta catalytic fragment generated in the apoptotic response to DNA damage. J Biol Chem. 2002 Sep 13; 277(37):33758-65.
    View in: PubMed
  137. Raina D, Mishra N, Kumar S, Kharbanda S, Saxena S, Kufe D. Inhibition of c-Abl with STI571 attenuates stress-activated protein kinase activation and apoptosis in the cellular response to 1-beta-D-arabinofuranosylcytosine. Mol Pharmacol. 2002 Jun; 61(6):1489-95.
    View in: PubMed
  138. Yoshida K, Komatsu K, Wang HG, Kufe D. c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage. Mol Cell Biol. 2002 May; 22(10):3292-300.
    View in: PubMed
  139. Epperly MW, Sikora CA, DeFilippi SJ, Gretton JA, Zhan Q, Kufe DW, Greenberger JS. Manganese superoxide dismutase (SOD2) inhibits radiation-induced apoptosis by stabilization of the mitochondrial membrane. Radiat Res. 2002 May; 157(5):568-77.
    View in: PubMed
  140. Gong J, Koido S, Chen D, Tanaka Y, Huang L, Avigan D, Anderson K, Ohno T, Kufe D. Immunization against murine multiple myeloma with fusions of dendritic and plasmacytoma cells is potentiated by interleukin 12. Blood. 2002 Apr 1; 99(7):2512-7.
    View in: PubMed
  141. Ren J, Li Y, Kufe D. Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signaling. J Biol Chem. 2002 May 17; 277(20):17616-22.
    View in: PubMed
  142. Koido S, Tanaka Y, Chen D, Kufe D, Gong J. The kinetics of in vivo priming of CD4 and CD8 T cells by dendritic/tumor fusion cells in MUC1-transgenic mice. J Immunol. 2002 Mar 1; 168(5):2111-7.
    View in: PubMed
  143. Mauceri HJ, Seetharam S, Beckett MA, Lee JY, Gupta VK, Gately S, Stack MS, Brown CK, Swedberg K, Kufe DW, Weichselbaum RR. Tumor production of angiostatin is enhanced after exposure to TNF-alpha. Int J Cancer. 2002 Feb 1; 97(4):410-5.
    View in: PubMed
  144. Reimer CL, Agata N, Tammam JG, Bamberg M, Dickerson WM, Kamphaus GD, Rook SL, Milhollen M, Fram R, Kalluri R, Kufe D, Kharbanda S. Antineoplastic effects of chemotherapeutic agents are potentiated by NM-3, an inhibitor of angiogenesis. Cancer Res. 2002 Feb 1; 62(3):789-95.
    View in: PubMed
  145. Gupta VK, Jaskowiak NT, Beckett MA, Mauceri HJ, Grunstein J, Johnson RS, Calvin DA, Nodzenski E, Pejovic M, Kufe DW, Posner MC, Weichselbaum RR. Vascular endothelial growth factor enhances endothelial cell survival and tumor radioresistance. Cancer J. 2002 Jan-Feb; 8(1):47-54.
    View in: PubMed
  146. Yoshida K, Kufe D. Negative regulation of the SHPTP1 protein tyrosine phosphatase by protein kinase C delta in response to DNA damage. Mol Pharmacol. 2001 Dec; 60(6):1431-8.
    View in: PubMed
  147. Yin L, Ohno T, Weichselbaum R, Kharbanda S, Kufe D. The novel isocoumarin 2-(8-hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-yl) propionic acid (NM-3) induces lethality of human carcinoma cells by generation of reactive oxygen species. Mol Cancer Ther. 2001 Nov; 1(1):43-8.
    View in: PubMed
  148. Bunnell CA, Supko JG, Eder JP, Clark JW, Lynch TJ, Kufe DW, Shulman LN. Phase I clinical trial of 7-cyanoquinocarcinol (DX-52-1) in adult patients with refractory solid malignancies. Cancer Chemother Pharmacol. 2001 Nov; 48(5):347-55.
    View in: PubMed
  149. Homma S, Toda G, Gong J, Kufe D, Ohno T. Preventive antitumor activity against hepatocellular carcinoma (HCC) induced by immunization with fusions of dendritic cells and HCC cells in mice. J Gastroenterol. 2001 Nov; 36(11):764-71.
    View in: PubMed
  150. Tanaka Y, Koido S, Chen D, Gendler SJ, Kufe D, Gong J. Vaccination with allogeneic dendritic cells fused to carcinoma cells induces antitumor immunity in MUC1 transgenic mice. Clin Immunol. 2001 Nov; 101(2):192-200.
    View in: PubMed
  151. Chmura SJ, Gupta N, Advani SJ, Kufe DW, Weichselbaum RR. Prospects for viral-based strategies enhancing the anti-tumor effects of ionizing radiation. Semin Radiat Oncol. 2001 Oct; 11(4):338-45.
    View in: PubMed
  152. Ito Y, Pandey P, Mishra N, Kumar S, Narula N, Kharbanda S, Saxena S, Kufe D. Targeting of the c-Abl tyrosine kinase to mitochondria in endoplasmic reticulum stress-induced apoptosis. Mol Cell Biol. 2001 Sep; 21(18):6233-42.
    View in: PubMed
  153. Majumder PK, Mishra NC, Sun X, Bharti A, Kharbanda S, Saxena S, Kufe D. Targeting of protein kinase C delta to mitochondria in the oxidative stress response. Cell Growth Differ. 2001 Sep; 12(9):465-70.
    View in: PubMed
  154. Ito Y, Mishra NC, Yoshida K, Kharbanda S, Saxena S, Kufe D. Mitochondrial targeting of JNK/SAPK in the phorbol ester response of myeloid leukemia cells. Cell Death Differ. 2001 Aug; 8(8):794-800.
    View in: PubMed
  155. Li Y, Ren J, Yu W, Li Q, Kuwahara H, Yin L, Carraway KL, Kufe D. The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin. J Biol Chem. 2001 Sep 21; 276(38):35239-42.
    View in: PubMed
  156. Gupta N, Nodzenski E, Khodarev NN, Yu J, Khorasani L, Beckett MA, Kufe DW, Weichselbaum RR. Angiostatin effects on endothelial cells mediated by ceramide and RhoA. EMBO Rep. 2001 Jun; 2(6):536-40.
    View in: PubMed
  157. Akewanlop C, Watanabe M, Singh B, Walker M, Kufe DW, Hayes DF. Phagocytosis of breast cancer cells mediated by anti-MUC-1 monoclonal antibody, DF3, and its bispecific antibody. Cancer Res. 2001 May 15; 61(10):4061-5.
    View in: PubMed
  158. Ito Y, Pandey P, Sporn MB, Datta R, Kharbanda S, Kufe D. The novel triterpenoid CDDO induces apoptosis and differentiation of human osteosarcoma cells by a caspase-8 dependent mechanism. Mol Pharmacol. 2001 May; 59(5):1094-9.
    View in: PubMed
  159. Kumar S, Bharti A, Mishra NC, Raina D, Kharbanda S, Saxena S, Kufe D. Targeting of the c-Abl tyrosine kinase to mitochondria in the necrotic cell death response to oxidative stress. J Biol Chem. 2001 May 18; 276(20):17281-5.
    View in: PubMed
  160. Cao C, Ren X, Kharbanda S, Koleske A, Prasad KV, Kufe D. The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress. J Biol Chem. 2001 Apr 13; 276(15):11465-8.
    View in: PubMed
  161. Li Y, Kufe D. The Human DF3/MUC1 carcinoma-associated antigen signals nuclear localization of the catenin p120(ctn). Biochem Biophys Res Commun. 2001 Feb 23; 281(2):440-3.
    View in: PubMed
  162. Villalona-Calero MA, Eder JP, Toppmeyer DL, Allen LF, Fram R, Velagapudi R, Myers M, Amato A, Kagen-Hallet K, Razvillas B, Kufe DW, Von Hoff DD, Rowinsky EK. Phase I and pharmacokinetic study of LU79553, a DNA intercalating bisnaphthalimide, in patients with solid malignancies. J Clin Oncol. 2001 Feb 1; 19(3):857-69.
    View in: PubMed
  163. Ito Y, Pandey P, Sathyanarayana P, Ling P, Rana A, Weichselbaum R, Tan TH, Kufe D, Kharbanda S. Interaction of hematopoietic progenitor kinase 1 and c-Abl tyrosine kinase in response to genotoxic stress. J Biol Chem. 2001 May 25; 276(21):18130-8.
    View in: PubMed
  164. Li Y, Kuwahara H, Ren J, Wen G, Kufe D. The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-catenin. J Biol Chem. 2001 Mar 2; 276(9):6061-4.
    View in: PubMed
  165. Weichselbaum RR, Kufe DW, Advani SJ, Roizman B. Molecular targeting of gene therapy and radiotherapy. Acta Oncol. 2001; 40(6):735-8.
    View in: PubMed
  166. Datta R, Yoshinaga K, Kaneki M, Pandey P, Kufe D. Phorbol ester-induced generation of reactive oxygen species is protein kinase cbeta -dependent and required for SAPK activation. J Biol Chem. 2000 Dec 29; 275(52):41000-3.
    View in: PubMed
  167. Salloum RM, Jaskowiak NT, Mauceri HJ, Seetharam S, Beckett MA, Koons AM, Hari DM, Gupta VK, Reimer C, Kalluri R, Posner MC, Hellman S, Kufe DW, Weichselbaum RR. NM-3, an isocoumarin, increases the antitumor effects of radiotherapy without toxicity. Cancer Res. 2000 Dec 15; 60(24):6958-63.
    View in: PubMed
  168. Koido S, Kashiwaba M, Chen D, Gendler S, Kufe D, Gong J. Induction of antitumor immunity by vaccination of dendritic cells transfected with MUC1 RNA. J Immunol. 2000 Nov 15; 165(10):5713-9.
    View in: PubMed
  169. Gong J, Apostolopoulos V, Chen D, Chen H, Koido S, Gendler SJ, McKenzie IF, Kufe D. Selection and characterization of MUC1-specific CD8+ T cells from MUC1 transgenic mice immunized with dendritic-carcinoma fusion cells. Immunology. 2000 Nov; 101(3):316-24.
    View in: PubMed
  170. Datta R, Oki E, Endo K, Biedermann V, Ren J, Kufe D. XIAP regulates DNA damage-induced apoptosis downstream of caspase-9 cleavage. J Biol Chem. 2000 Oct 13; 275(41):31733-8.
    View in: PubMed
  171. Hanna NN, Seetharam S, Mauceri HJ, Beckett MA, Jaskowiak NT, Salloum RM, Hari D, Dhanabal M, Ramchandran R, Kalluri R, Sukhatme VP, Kufe DW, Weichselbaum RR. Antitumor interaction of short-course endostatin and ionizing radiation. Cancer J. 2000 Sep-Oct; 6(5):287-93.
    View in: PubMed
  172. Kurihara T, Brough DE, Kovesdi I, Kufe DW. Selectivity of a replication-competent adenovirus for human breast carcinoma cells expressing the MUC1 antigen. J Clin Invest. 2000 Sep; 106(6):763-71.
    View in: PubMed
  173. Pandey P, Saleh A, Nakazawa A, Kumar S, Srinivasula SM, Kumar V, Weichselbaum R, Nalin C, Alnemri ES, Kufe D, Kharbanda S. Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90. EMBO J. 2000 Aug 15; 19(16):4310-22.
    View in: PubMed
  174. Pandey P, Nakazawa A, Ito Y, Datta R, Kharbanda S, Kufe D. Requirement for caspase activation in monocytic differentiation of myeloid leukemia cells. Oncogene. 2000 Aug 10; 19(34):3941-7.
    View in: PubMed
  175. Yoshida K, Weichselbaum R, Kharbanda S, Kufe D. Role for Lyn tyrosine kinase as a regulator of stress-activated protein kinase activity in response to DNA damage. Mol Cell Biol. 2000 Aug; 20(15):5370-80.
    View in: PubMed
  176. Gong J, Nikrui N, Chen D, Koido S, Wu Z, Tanaka Y, Cannistra S, Avigan D, Kufe D. Fusions of human ovarian carcinoma cells with autologous or allogeneic dendritic cells induce antitumor immunity. J Immunol. 2000 Aug 1; 165(3):1705-11.
    View in: PubMed
  177. Majumder PK, Pandey P, Sun X, Cheng K, Datta R, Saxena S, Kharbanda S, Kufe D. Mitochondrial translocation of protein kinase C delta in phorbol ester-induced cytochrome c release and apoptosis. J Biol Chem. 2000 Jul 21; 275(29):21793-6.
    View in: PubMed
  178. Avigan D, Wu Z, Joyce R, Elias A, Richardson P, McDermott D, Levine J, Kennedy L, Giallombardo N, Hurley D, Gong J, Kufe D. Immune reconstitution following high-dose chemotherapy with stem cell rescue in patients with advanced breast cancer. Bone Marrow Transplant. 2000 Jul; 26(2):169-76.
    View in: PubMed
  179. Kharbanda S, Pandey P, Yamauchi T, Kumar S, Kaneki M, Kumar V, Bharti A, Yuan ZM, Ghanem L, Rana A, Weichselbaum R, Johnson G, Kufe D. Activation of MEK kinase 1 by the c-Abl protein tyrosine kinase in response to DNA damage. Mol Cell Biol. 2000 Jul; 20(14):4979-89.
    View in: PubMed
  180. Endo K, Oki E, Biedermann V, Kojima H, Yoshida K, Johannes FJ, Kufe D, Datta R. Proteolytic cleavage and activation of protein kinase C [micro] by caspase-3 in the apoptotic response of cells to 1-beta -D-arabinofuranosylcytosine and other genotoxic agents. J Biol Chem. 2000 Jun 16; 275(24):18476-81.
    View in: PubMed
  181. Sun X, Majumder P, Shioya H, Wu F, Kumar S, Weichselbaum R, Kharbanda S, Kufe D. Activation of the cytoplasmic c-Abl tyrosine kinase by reactive oxygen species. J Biol Chem. 2000 Jun 9; 275(23):17237-40.
    View in: PubMed
  182. Kharbanda S, Kumar V, Dhar S, Pandey P, Chen C, Majumder P, Yuan ZM, Whang Y, Strauss W, Pandita TK, Weaver D, Kufe D. Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase. Curr Biol. 2000 May 18; 10(10):568-75.
    View in: PubMed
  183. Colorado PC, Torre A, Kamphaus G, Maeshima Y, Hopfer H, Takahashi K, Volk R, Zamborsky ED, Herman S, Sarkar PK, Ericksen MB, Dhanabal M, Simons M, Post M, Kufe DW, Weichselbaum RR, Sukhatme VP, Kalluri R. Anti-angiogenic cues from vascular basement membrane collagen. Cancer Res. 2000 May 1; 60(9):2520-6.
    View in: PubMed
  184. Eder JP, Kantoff PW, Roper K, Xu GX, Bubley GJ, Boyden J, Gritz L, Mazzara G, Oh WK, Arlen P, Tsang KY, Panicali D, Schlom J, Kufe DW. A phase I trial of a recombinant vaccinia virus expressing prostate-specific antigen in advanced prostate cancer. Clin Cancer Res. 2000 May; 6(5):1632-8.
    View in: PubMed
  185. Hari D, Beckett MA, Sukhatme VP, Dhanabal M, Nodzenski E, Lu H, Mauceri HJ, Kufe DW, Weichselbaum RR. Angiostatin induces mitotic cell death of proliferating endothelial cells. Mol Cell Biol Res Commun. 2000 May; 3(5):277-82.
    View in: PubMed
  186. Ito Y, Pandey P, Place A, Sporn MB, Gribble GW, Honda T, Kharbanda S, Kufe D. The novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid induces apoptosis of human myeloid leukemia cells by a caspase-8-dependent mechanism. Cell Growth Differ. 2000 May; 11(5):261-7.
    View in: PubMed
  187. Kumar V, Sabatini D, Pandey P, Gingras AC, Majumder PK, Kumar M, Yuan ZM, Carmichael G, Weichselbaum R, Sonenberg N, Kufe D, Kharbanda S. Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase. J Biol Chem. 2000 Apr 14; 275(15):10779-87.
    View in: PubMed
  188. Pandey P, Farber R, Nakazawa A, Kumar S, Bharti A, Nalin C, Weichselbaum R, Kufe D, Kharbanda S. Hsp27 functions as a negative regulator of cytochrome c-dependent activation of procaspase-3. Oncogene. 2000 Apr 13; 19(16):1975-81.
    View in: PubMed
  189. Chmura SJ, Nodzenski E, Kharbanda S, Pandey P, Quintans J, Kufe DW, Weichselbaum RR. Down-regulation of ceramide production abrogates ionizing radiation-induced cytochrome c release and apoptosis. Mol Pharmacol. 2000 Apr; 57(4):792-6.
    View in: PubMed
  190. Sun X, Wu F, Datta R, Kharbanda S, Kufe D. Interaction between protein kinase C delta and the c-Abl tyrosine kinase in the cellular response to oxidative stress. J Biol Chem. 2000 Mar 17; 275(11):7470-3.
    View in: PubMed
  191. Gong J, Avigan D, Chen D, Wu Z, Koido S, Kashiwaba M, Kufe D. Activation of antitumor cytotoxic T lymphocytes by fusions of human dendritic cells and breast carcinoma cells. Proc Natl Acad Sci U S A. 2000 Mar 14; 97(6):2715-8.
    View in: PubMed
  192. Kumar V, Pandey P, Sabatini D, Kumar M, Majumder PK, Bharti A, Carmichael G, Kufe D, Kharbanda S. Functional interaction between RAFT1/FRAP/mTOR and protein kinase cdelta in the regulation of cap-dependent initiation of translation. EMBO J. 2000 Mar 1; 19(5):1087-97.
    View in: PubMed
  193. Kufe DW. Smallpox, polio and now a cancer vaccine? Nat Med. 2000 Mar; 6(3):252-3.
    View in: PubMed
  194. Chmura SJ, Dolan ME, Cha A, Mauceri HJ, Kufe DW, Weichselbaum RR. In vitro and in vivo activity of protein kinase C inhibitor chelerythrine chloride induces tumor cell toxicity and growth delay in vivo. Clin Cancer Res. 2000 Feb; 6(2):737-42.
    View in: PubMed
  195. Kharbanda S, Saxena S, Yoshida K, Pandey P, Kaneki M, Wang Q, Cheng K, Chen YN, Campbell A, Sudha T, Yuan ZM, Narula J, Weichselbaum R, Nalin C, Kufe D. Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage. J Biol Chem. 2000 Jan 7; 275(1):322-7.
    View in: PubMed
  196. Supko JG, Lynch TJ, Clark JW, Fram R, Allen LF, Velagapudi R, Kufe DW, Eder JP. A phase I clinical and pharmacokinetic study of the dolastatin analogue cemadotin administered as a 5-day continuous intravenous infusion. Cancer Chemother Pharmacol. 2000; 46(4):319-28.
    View in: PubMed
  197. Yoshida K, Kharbanda S, Kufe D. Functional interaction between SHPTP1 and the Lyn tyrosine kinase in the apoptotic response to DNA damage. J Biol Chem. 1999 Dec 3; 274(49):34663-8.
    View in: PubMed
  198. Yuan ZM, Huang Y, Ishiko T, Nakada S, Utsugisawa T, Shioya H, Utsugisawa Y, Shi Y, Weichselbaum R, Kufe D. Function for p300 and not CBP in the apoptotic response to DNA damage. Oncogene. 1999 Oct 7; 18(41):5714-7.
    View in: PubMed
  199. Avigan D, Wu Z, Gong J, Joyce R, Levine J, Elias A, Richardson P, Milano J, Kennedy L, Anderson K, Kufe D. Selective in vivo mobilization with granulocyte macrophage colony-stimulating factor (GM-CSF)/granulocyte-CSF as compared to G-CSF alone of dendritic cell progenitors from peripheral blood progenitor cells in patients with advanced breast cancer undergoing autologous transplantation. Clin Cancer Res. 1999 Oct; 5(10):2735-41.
    View in: PubMed
  200. Seetharam S, Staba MJ, Schumm LP, Schreiber K, Schreiber H, Kufe DW, Weichselbaum RR. Enhanced eradication of local and distant tumors by genetically produced interleukin-12 and radiation. Int J Oncol. 1999 Oct; 15(4):769-73.
    View in: PubMed
  201. Gorski DH, Beckett MA, Jaskowiak NT, Calvin DP, Mauceri HJ, Salloum RM, Seetharam S, Koons A, Hari DM, Kufe DW, Weichselbaum RR. Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Res. 1999 Jul 15; 59(14):3374-8.
    View in: PubMed
  202. Yuan ZM, Shioya H, Ishiko T, Sun X, Gu J, Huang YY, Lu H, Kharbanda S, Weichselbaum R, Kufe D. p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Nature. 1999 Jun 24; 399(6738):814-7.
    View in: PubMed
  203. Tai YT, Strobel T, Kufe D, Cannistra SA. In vivo cytotoxicity of ovarian cancer cells through tumor-selective expression of the BAX gene. Cancer Res. 1999 May 1; 59(9):2121-6.
    View in: PubMed
  204. Huang Y, Nakada S, Ishiko T, Utsugisawa T, Datta R, Kharbanda S, Yoshida K, Talanian RV, Weichselbaum R, Kufe D, Yuan ZM. Role for caspase-mediated cleavage of Rad51 in induction of apoptosis by DNA damage. Mol Cell Biol. 1999 Apr; 19(4):2986-97.
    View in: PubMed
  205. Raje N, Gong J, Chauhan D, Teoh G, Avigan D, Wu Z, Chen D, Treon SP, Webb IJ, Kufe DW, Anderson KC. Bone marrow and peripheral blood dendritic cells from patients with multiple myeloma are phenotypically and functionally normal despite the detection of Kaposi's sarcoma herpesvirus gene sequences. Blood. 1999 Mar 1; 93(5):1487-95.
    View in: PubMed
  206. Guo XY, Balague C, Wang T, Randhawa G, Yuan Z, Bachier C, Greenberger J, Arlinghaus R, Kufe D, Deisseroth AB. The presence of the Rb c-box peptide in the cytoplasm inhibits p210bcr-abl transforming function. Oncogene. 1999 Feb 25; 18(8):1589-95.
    View in: PubMed
  207. Mauceri HJ, Hanna NN, Staba MJ, Beckett MA, Kufe DW, Weichselbaum RR. Radiation-inducible gene therapy. C R Acad Sci III. 1999 Feb-Mar; 322(2-3):225-8.
    View in: PubMed
  208. Yuan ZM, Huang Y, Ishiko T, Nakada S, Utsugisawa T, Shioya H, Utsugisawa Y, Yokoyama K, Weichselbaum R, Shi Y, Kufe D. Role for p300 in stabilization of p53 in the response to DNA damage. J Biol Chem. 1999 Jan 22; 274(4):1883-6.
    View in: PubMed
  209. Chmura SJ, Advani SJ, Kufe DW, Weichselbaum RR. Strategies for enhancing viral-based gene therapy using ionizing radiation. Radiat Oncol Investig. 1999; 7(5):261-9.
    View in: PubMed
  210. Kaneki M, Kharbanda S, Pandey P, Yoshida K, Takekawa M, Liou JR, Stone R, Kufe D. Functional role for protein kinase Cbeta as a regulator of stress-activated protein kinase activation and monocytic differentiation of myeloid leukemia cells. Mol Cell Biol. 1999 Jan; 19(1):461-70.
    View in: PubMed
  211. Kharbanda S, Yuan ZM, Weichselbaum R, Kufe D. Determination of cell fate by c-Abl activation in the response to DNA damage. Oncogene. 1998 Dec 24; 17(25):3309-18.
    View in: PubMed
  212. Teoh G, Chen L, Urashima M, Tai YT, Celi LA, Chen D, Chauhan D, Ogata A, Finberg RW, Webb IJ, Kufe DW, Anderson KC. Adenovirus vector-based purging of multiple myeloma cells. Blood. 1998 Dec 15; 92(12):4591-601.
    View in: PubMed
  213. Gorski DH, Mauceri HJ, Salloum RM, Gately S, Hellman S, Beckett MA, Sukhatme VP, Soff GA, Kufe DW, Weichselbaum RR. Potentiation of the antitumor effect of ionizing radiation by brief concomitant exposures to angiostatin. Cancer Res. 1998 Dec 15; 58(24):5686-9.
    View in: PubMed
  214. Li Y, Bharti A, Chen D, Gong J, Kufe D. Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin. Mol Cell Biol. 1998 Dec; 18(12):7216-24.
    View in: PubMed
  215. Bharti A, Kraeft SK, Gounder M, Pandey P, Jin S, Yuan ZM, Lees-Miller SP, Weichselbaum R, Weaver D, Chen LB, Kufe D, Kharbanda S. Inactivation of DNA-dependent protein kinase by protein kinase Cdelta: implications for apoptosis. Mol Cell Biol. 1998 Nov; 18(11):6719-28.
    View in: PubMed
  216. Chung TD, Mauceri HJ, Hallahan DE, Yu JJ, Chung S, Grdina WL, Yajnik S, Kufe DW, Weichselbaum RR. Tumor necrosis factor-alpha-based gene therapy enhances radiation cytotoxicity in human prostate cancer. Cancer Gene Ther. 1998 Nov-Dec; 5(6):344-9.
    View in: PubMed
  217. Liedtke M, Pandey P, Kumar S, Kharbanda S, Kufe D. Regulation of Bcr-Abl-induced SAP kinase activity and transformation by the SHPTP1 protein tyrosine phosphatase. Oncogene. 1998 Oct 15; 17(15):1889-92.
    View in: PubMed
  218. Kumar S, Pandey P, Bharti A, Jin S, Weichselbaum R, Weaver D, Kufe D, Kharbanda S. Regulation of DNA-dependent protein kinase by the Lyn tyrosine kinase. J Biol Chem. 1998 Oct 2; 273(40):25654-8.
    View in: PubMed
  219. Cristofanilli M, Bryan WJ, Miller LL, Chang AY, Gradishar WJ, Kufe DW, Hortobagyi GN. Phase II study of adozelesin in untreated metastatic breast cancer. Anticancer Drugs. 1998 Oct; 9(9):779-82.
    View in: PubMed
  220. Seetharam S, Nodzenski E, Beckett MA, Heimann R, Cha A, Margulies I, Pastan I, Kufe DW, Weichselbaum RR. Modulation of apoptotic response of a radiation-resistant human carcinoma by Pseudomonas exotoxin-chimeric protein. Cancer Res. 1998 Aug 1; 58(15):3215-20.
    View in: PubMed
  221. Mauceri HJ, Hanna NN, Beckett MA, Gorski DH, Staba MJ, Stellato KA, Bigelow K, Heimann R, Gately S, Dhanabal M, Soff GA, Sukhatme VP, Kufe DW, Weichselbaum RR. Combined effects of angiostatin and ionizing radiation in antitumour therapy. Nature. 1998 Jul 16; 394(6690):287-91.
    View in: PubMed
  222. Kojima H, Endo K, Moriyama H, Tanaka Y, Alnemri ES, Slapak CA, Teicher B, Kufe D, Datta R. Abrogation of mitochondrial cytochrome c release and caspase-3 activation in acquired multidrug resistance. J Biol Chem. 1998 Jul 3; 273(27):16647-50.
    View in: PubMed
  223. Guo XY, Fontana J, Kufe D, Deisseroth A. Antagonistic effects of ABL and BCRABL proteins on proliferation and the response to genotoxic stress in normal and leukemic myeloid cells. Leuk Lymphoma. 1998 Jul; 30(3-4):225-35.
    View in: PubMed
  224. Manome Y, Kunieda T, Wen PY, Koga T, Kufe DW, Ohno T. Transgene expression in malignant glioma using a replication-defective adenoviral vector containing the Egr-1 promoter: activation by ionizing radiation or uptake of radioactive iododeoxyuridine. Hum Gene Ther. 1998 Jul 1; 9(10):1409-17.
    View in: PubMed
  225. Gong J, Chen D, Kashiwaba M, Li Y, Chen L, Takeuchi H, Qu H, Rowse GJ, Gendler SJ, Kufe D. Reversal of tolerance to human MUC1 antigen in MUC1 transgenic mice immunized with fusions of dendritic and carcinoma cells. Proc Natl Acad Sci U S A. 1998 May 26; 95(11):6279-83.
    View in: PubMed
  226. Kharbanda S, Pandey P, Morris PL, Whang Y, Xu Y, Sawant S, Zhu LJ, Kumar N, Yuan ZM, Weichselbaum R, Sawyers CL, Pandita TK, Kufe D. Functional role for the c-Abl tyrosine kinase in meiosis I. Oncogene. 1998 Apr 9; 16(14):1773-7.
    View in: PubMed
  227. Yuan ZM, Utsugisawa T, Ishiko T, Nakada S, Huang Y, Kharbanda S, Weichselbaum R, Kufe D. Activation of protein kinase C delta by the c-Abl tyrosine kinase in response to ionizing radiation. Oncogene. 1998 Apr 2; 16(13):1643-8.
    View in: PubMed
  228. Staba MJ, Mauceri HJ, Kufe DW, Hallahan DE, Weichselbaum RR. Adenoviral TNF-alpha gene therapy and radiation damage tumor vasculature in a human malignant glioma xenograft. Gene Ther. 1998 Mar; 5(3):293-300.
    View in: PubMed
  229. Yuan ZM, Huang Y, Ishiko T, Nakada S, Utsugisawa T, Kharbanda S, Wang R, Sung P, Shinohara A, Weichselbaum R, Kufe D. Regulation of Rad51 function by c-Abl in response to DNA damage. J Biol Chem. 1998 Feb 13; 273(7):3799-802.
    View in: PubMed
  230. Eder JP, Supko JG, Lynch T, Bryant M, Vosburgh E, Shulman LN, Xu G, Kufe DW. Phase I trial of the colloidal dispersion formulation of 9-amino-20(S)-camptothecin administered as a 72-hour continuous intravenous infusion. Clin Cancer Res. 1998 Feb; 4(2):317-24.
    View in: PubMed
  231. Chauhan D, Pandey P, Ogata A, Teoh G, Krett N, Halgren R, Rosen S, Kufe D, Kharbanda S, Anderson K. Cytochrome c-dependent and -independent induction of apoptosis in multiple myeloma cells. J Biol Chem. 1997 Nov 28; 272(48):29995-7.
    View in: PubMed
  232. Kharbanda S, Yuan ZM, Weichselbaum R, Kufe D. Functional role for the c-Abl protein tyrosine kinase in the cellular response to genotoxic stress. Biochim Biophys Acta. 1997 Oct 24; 1333(2):O1-7.
    View in: PubMed
  233. Huang Y, Yuan ZM, Ishiko T, Nakada S, Utsugisawa T, Kato T, Kharbanda S, Kufe DW. Pro-apoptotic effect of the c-Abl tyrosine kinase in the cellular response to 1-beta-D-arabinofuranosylcytosine. Oncogene. 1997 Oct 16; 15(16):1947-52.
    View in: PubMed
  234. Jin S, Kharbanda S, Mayer B, Kufe D, Weaver DT. Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit. J Biol Chem. 1997 Oct 3; 272(40):24763-6.
    View in: PubMed
  235. Parr MJ, Manome Y, Tanaka T, Wen P, Kufe DW, Kaelin WG, Fine HA. Tumor-selective transgene expression in vivo mediated by an E2F-responsive adenoviral vector. Nat Med. 1997 Oct; 3(10):1145-9.
    View in: PubMed
  236. Hanna NN, Mauceri HJ, Wayne JD, Hallahan DE, Kufe DW, Weichselbaum RR. Virally directed cytosine deaminase/5-fluorocytosine gene therapy enhances radiation response in human cancer xenografts. Cancer Res. 1997 Oct 1; 57(19):4205-9.
    View in: PubMed
  237. Gong J, Chen L, Chen D, Kashiwaba M, Manome Y, Tanaka T, Kufe D. Induction of antigen-specific antitumor immunity with adenovirus-transduced dendritic cells. Gene Ther. 1997 Oct; 4(10):1023-8.
    View in: PubMed
  238. Chmura SJ, Mauceri HJ, Advani S, Heimann R, Beckett MA, Nodzenski E, Quintans J, Kufe DW, Weichselbaum RR. Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation. Cancer Res. 1997 Oct 1; 57(19):4340-7.
    View in: PubMed
  239. Yuan ZM, Utsugisawa T, Huang Y, Ishiko T, Nakada S, Kharbanda S, Weichselbaum R, Kufe D. Inhibition of phosphatidylinositol 3-kinase by c-Abl in the genotoxic stress response. J Biol Chem. 1997 Sep 19; 272(38):23485-8.
    View in: PubMed
  240. Datta R, Kojima H, Yoshida K, Kufe D. Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis. J Biol Chem. 1997 Aug 15; 272(33):20317-20.
    View in: PubMed
  241. Chen L, Chen D, Block E, O'Donnell M, Kufe DW, Clinton SK. Eradication of murine bladder carcinoma by intratumor injection of a bicistronic adenoviral vector carrying cDNAs for the IL-12 heterodimer and its inhibition by the IL-12 p40 subunit homodimer. J Immunol. 1997 Jul 1; 159(1):351-9.
    View in: PubMed
  242. Kharbanda S, Pandey P, Schofield L, Israels S, Roncinske R, Yoshida K, Bharti A, Yuan ZM, Saxena S, Weichselbaum R, Nalin C, Kufe D. Role for Bcl-xL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6939-42.
    View in: PubMed
  243. Shafman T, Khanna KK, Kedar P, Spring K, Kozlov S, Yen T, Hobson K, Gatei M, Zhang N, Watters D, Egerton M, Shiloh Y, Kharbanda S, Kufe D, Lavin MF. Interaction between ATM protein and c-Abl in response to DNA damage. Nature. 1997 May 29; 387(6632):520-3.
    View in: PubMed
  244. Yamamoto M, Bharti A, Li Y, Kufe D. Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesion. J Biol Chem. 1997 May 9; 272(19):12492-4.
    View in: PubMed
  245. Weichselbaum RR, Kufe D. Gene therapy of cancer. Lancet. 1997 May; 349 Suppl 2:SII10-2.
    View in: PubMed
  246. Gong J, Chen D, Kashiwaba M, Kufe D. Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells. Nat Med. 1997 May; 3(5):558-61.
    View in: PubMed
  247. Kharbanda S, Pandey P, Jin S, Inoue S, Bharti A, Yuan ZM, Weichselbaum R, Weaver D, Kufe D. Functional interaction between DNA-PK and c-Abl in response to DNA damage. Nature. 1997 Apr 17; 386(6626):732-5.
    View in: PubMed
  248. Li XG, Haluska P, Hsiang YH, Bharti AK, Kufe DW, Liu LF, Rubin EH. Involvement of amino acids 361 to 364 of human topoisomerase I in camptothecin resistance and enzyme catalysis. Biochem Pharmacol. 1997 Apr 4; 53(7):1019-27.
    View in: PubMed
  249. Tanaka T, Manome Y, Wen P, Kufe DW, Fine HA. Viral vector-mediated transduction of a modified platelet factor 4 cDNA inhibits angiogenesis and tumor growth. Nat Med. 1997 Apr; 3(4):437-42.
    View in: PubMed
  250. Tsuji K, Uwano T, Yoshida Y, Kikuchi K, Okamoto T, Yamamoto S, Ichiki M, Hayashi I, Ohno T, Kufe DW. Detection of the circulating lung cancer marker LCAP with a new monoclonal antibody TRD-L1. Int J Biol Markers. 1997 Apr-Jun; 12(2):49-54.
    View in: PubMed
  251. Chmura SJ, Nodzenski E, Beckett MA, Kufe DW, Quintans J, Weichselbaum RR. Loss of ceramide production confers resistance to radiation-induced apoptosis. Cancer Res. 1997 Apr 1; 57(7):1270-5.
    View in: PubMed
  252. Yuan ZM, Huang Y, Ishiko T, Kharbanda S, Weichselbaum R, Kufe D. Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase. Proc Natl Acad Sci U S A. 1997 Feb 18; 94(4):1437-40.
    View in: PubMed
  253. Datta R, Kojima H, Banach D, Bump NJ, Talanian RV, Alnemri ES, Weichselbaum RR, Wong WW, Kufe DW. Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis. J Biol Chem. 1997 Jan 17; 272(3):1965-9.
    View in: PubMed
  254. Akagi J, Hodge JW, McLaughlin JP, Gritz L, Mazzara G, Kufe D, Schlom J, Kantor JA. Therapeutic antitumor response after immunization with an admixture of recombinant vaccinia viruses expressing a modified MUC1 gene and the murine T-cell costimulatory molecule B7. J Immunother. 1997 Jan; 20(1):38-47.
    View in: PubMed
  255. Chauhan D, Kharbanda S, Ogata A, Urashima M, Teoh G, Robertson M, Kufe DW, Anderson KC. Interleukin-6 inhibits Fas-induced apoptosis and stress-activated protein kinase activation in multiple myeloma cells. Blood. 1997 Jan 1; 89(1):227-34.
    View in: PubMed
  256. Eder JP, Rubin E, Stone R, Bryant M, Xu G, Supko J, Kinchla N, Lynch T, Hurwitz S, Rodriguez D, Shapiro C, Toppmeyer D, Grossbard M, Vosburg E, Huberman M, Schnipper L, Shulman L, Kufe DW. Trials of 9-amino-20(S)-camptothecin in Boston. Ann N Y Acad Sci. 1996 Dec 13; 803:247-55.
    View in: PubMed
  257. Li XG, Haluska P, Hsiang YH, Bharti A, Kufe DW, Rubin EH. Identification of topoisomerase I mutations affecting both DNA cleavage and interaction with camptothecin. Ann N Y Acad Sci. 1996 Dec 13; 803:111-27.
    View in: PubMed
  258. Gimmi CD, Morrison BW, Mainprice BA, Gribben JG, Boussiotis VA, Freeman GJ, Park SY, Watanabe M, Gong J, Hayes DF, Kufe DW, Nadler LM. Breast cancer-associated antigen, DF3/MUC1, induces apoptosis of activated human T cells. Nat Med. 1996 Dec; 2(12):1367-70.
    View in: PubMed
  259. Ghayur T, Hugunin M, Talanian RV, Ratnofsky S, Quinlan C, Emoto Y, Pandey P, Datta R, Huang Y, Kharbanda S, Allen H, Kamen R, Wong W, Kufe D. Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis. J Exp Med. 1996 Dec 1; 184(6):2399-404.
    View in: PubMed
  260. Chen L, Pulsipher M, Chen D, Sieff C, Elias A, Fine HA, Kufe DW. Selective transgene expression for detection and elimination of contaminating carcinoma cells in hematopoietic stem cell sources. J Clin Invest. 1996 Dec 1; 98(11):2539-48.
    View in: PubMed
  261. Yuan ZM, Huang Y, Fan MM, Sawyers C, Kharbanda S, Kufe D. Genotoxic drugs induce interaction of the c-Abl tyrosine kinase and the tumor suppressor protein p53. J Biol Chem. 1996 Oct 25; 271(43):26457-60.
    View in: PubMed
  262. Pandey P, Raingeaud J, Kaneki M, Weichselbaum R, Davis RJ, Kufe D, Kharbanda S. Activation of p38 mitogen-activated protein kinase by c-Abl-dependent and -independent mechanisms. J Biol Chem. 1996 Sep 27; 271(39):23775-9.
    View in: PubMed
  263. Datta R, Banach D, Kojima H, Talanian RV, Alnemri ES, Wong WW, Kufe DW. Activation of the CPP32 protease in apoptosis induced by 1-beta-D-arabinofuranosylcytosine and other DNA-damaging agents. Blood. 1996 Sep 15; 88(6):1936-43.
    View in: PubMed
  264. Yuan ZM, Huang Y, Kraeft SK, Chen LB, Kharbanda S, Kufe D. Interaction of cyclin-dependent kinase 2 and the Lyn tyrosine kinase in cells treated with 1-beta-D-arabinofuranosylcytosine. Oncogene. 1996 Sep 5; 13(5):939-46.
    View in: PubMed
  265. Kharbanda S, Saleem A, Yuan ZM, Kraeft S, Weichselbaum R, Chen LB, Kufe D. Nuclear signaling induced by ionizing radiation involves colocalization of the activated p56/p53lyn tyrosine kinase with p34cdc2. Cancer Res. 1996 Aug 15; 56(16):3617-21.
    View in: PubMed
  266. Yuan ZM, Huang Y, Whang Y, Sawyers C, Weichselbaum R, Kharbanda S, Kufe D. Role for c-Abl tyrosine kinase in growth arrest response to DNA damage. Nature. 1996 Jul 18; 382(6588):272-4.
    View in: PubMed
  267. Kharbanda S, Bharti A, Pei D, Wang J, Pandey P, Ren R, Weichselbaum R, Walsh CT, Kufe D. The stress response to ionizing radiation involoves c-Abl-dependent phosphorylation of SHPTP1. Proc Natl Acad Sci U S A. 1996 Jul 9; 93(14):6898-901.
    View in: PubMed
  268. Manome Y, Wen PY, Chen L, Tanaka T, Dong Y, Yamazoe M, Hirshowitz A, Kufe DW, Fine HA. Gene therapy for malignant gliomas using replication incompetent retroviral and adenoviral vectors encoding the cytochrome P450 2B1 gene together with cyclophosphamide. Gene Ther. 1996 Jun; 3(6):513-20.
    View in: PubMed
  269. Manome Y, Wen PY, Dong Y, Tanaka T, Mitchell BS, Kufe DW, Fine HA. Viral vector transduction of the human deoxycytidine kinase cDNA sensitizes glioma cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo. Nat Med. 1996 May; 2(5):567-73.
    View in: PubMed
  270. Dong Y, Wen P, Manome Y, Parr M, Hirshowitz A, Chen L, Hirschowitz EA, Crystal R, Weichselbaum R, Kufe DW, Fine HA. In vivo replication-deficient adenovirus vector-mediated transduction of the cytosine deaminase gene sensitizes glioma cells to 5-fluorocytosine. Hum Gene Ther. 1996 Apr 10; 7(6):713-20.
    View in: PubMed
  271. Chen L, Waxman DJ, Chen D, Kufe DW. Sensitization of human breast cancer cells to cyclophosphamide and ifosfamide by transfer of a liver cytochrome P450 gene. Cancer Res. 1996 Mar 15; 56(6):1331-40.
    View in: PubMed
  272. Emoto Y, Kisaki H, Manome Y, Kharbanda S, Kufe D. Activation of protein kinase Cdelta in human myeloid leukemia cells treated with 1-beta-D-arabinofuranosylcytosine. Blood. 1996 Mar 1; 87(5):1990-6.
    View in: PubMed
  273. Manome Y, Yao XJ, Kufe DW, Cohen EA, Fine HA. Selective effects of DNA damaging agents on HIV long terminal repeat activation and virus replication in vitro. J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1; 11(2):109-16.
    View in: PubMed
  274. Bharti AK, Olson MO, Kufe DW, Rubin EH. Identification of a nucleolin binding site in human topoisomerase I. J Biol Chem. 1996 Jan 26; 271(4):1993-7.
    View in: PubMed
  275. Kharbanda S, Pandey P, Ren R, Mayer B, Zon L, Kufe D. c-Abl activation regulates induction of the SEK1/stress-activated protein kinase pathway in the cellular response to 1-beta-D-arabinofuranosylcytosine. J Biol Chem. 1995 Dec 22; 270(51):30278-81.
    View in: PubMed
  276. Hallahan DE, Dunphy E, Virudachalam S, Sukhatme VP, Kufe DW, Weichselbaum RR. C-jun and Egr-1 participate in DNA synthesis and cell survival in response to ionizing radiation exposure. J Biol Chem. 1995 Dec 22; 270(51):30303-9.
    View in: PubMed
  277. Saleem A, Datta R, Yuan ZM, Kharbanda S, Kufe D. Involvement of stress-activated protein kinase in the cellular response to 1-beta-D-arabinofuranosylcytosine and other DNA-damaging agents. Cell Growth Differ. 1995 Dec; 6(12):1651-8.
    View in: PubMed
  278. Chen L, Chen D, Manome Y, Dong Y, Fine HA, Kufe DW. Breast cancer selective gene expression and therapy mediated by recombinant adenoviruses containing the DF3/MUC1 promoter. J Clin Invest. 1995 Dec; 96(6):2775-82.
    View in: PubMed
  279. Chauhan D, Kharbanda SM, Ogata A, Urashima M, Frank D, Malik N, Kufe DW, Anderson KC. Oncostatin M induces association of Grb2 with Janus kinase JAK2 in multiple myeloma cells. J Exp Med. 1995 Dec 1; 182(6):1801-6.
    View in: PubMed
  280. Manome Y, Wen PY, Hershowitz A, Tanaka T, Rollins BJ, Kufe DW, Fine HA. Monocyte chemoattractant protein-1 (MCP-1) gene transduction: an effective tumor vaccine strategy for non-intracranial tumors. Cancer Immunol Immunother. 1995 Oct; 41(4):227-35.
    View in: PubMed
  281. Pandey P, Kharbanda S, Kufe D. Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein. Cancer Res. 1995 Sep 15; 55(18):4000-3.
    View in: PubMed
  282. Hallahan DE, Vokes EE, Rubin SJ, O'Brien S, Samuels B, Vijaykumar S, Kufe DW, Phillips R, Weichselbaum RR. Phase I dose-escalation study of tumor necrosis factor-alpha and concomitant radiation therapy. Cancer J Sci Am. 1995 Sep-Oct; 1(3):204-9.
    View in: PubMed
  283. Kharbanda S, Ren R, Pandey P, Shafman TD, Feller SM, Weichselbaum RR, Kufe DW. Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents. Nature. 1995 Aug 31; 376(6543):785-8.
    View in: PubMed
  284. Shafman TD, Saleem A, Kyriakis J, Weichselbaum R, Kharbanda S, Kufe DW. Defective induction of stress-activated protein kinase activity in ataxia-telangiectasia cells exposed to ionizing radiation. Cancer Res. 1995 Aug 1; 55(15):3242-5.
    View in: PubMed
  285. Hallahan DE, Mauceri HJ, Seung LP, Dunphy EJ, Wayne JD, Hanna NN, Toledano A, Hellman S, Kufe DW, Weichselbaum RR. Spatial and temporal control of gene therapy using ionizing radiation. Nat Med. 1995 Aug; 1(8):786-91.
    View in: PubMed
  286. Kharbanda S, Saleem A, Yuan Z, Emoto Y, Prasad KV, Kufe D. Stimulation of human monocytes with macrophage colony-stimulating factor induces a Grb2-mediated association of the focal adhesion kinase pp125FAK and dynamin. Proc Natl Acad Sci U S A. 1995 Jun 20; 92(13):6132-6.
    View in: PubMed
  287. Saleem A, Kharbanda S, Yuan ZM, Kufe D. Monocyte colony-stimulating factor stimulates binding of phosphatidylinositol 3-kinase to Grb2.Sos complexes in human monocytes. J Biol Chem. 1995 May 5; 270(18):10380-3.
    View in: PubMed
  288. Ichige K, Perey L, Vogel CA, Buchegger F, Kufe D. Expression of the DF3-P epitope in human ovarian carcinomas. Clin Cancer Res. 1995 May; 1(5):565-71.
    View in: PubMed
  289. Saleem A, Yuan ZM, Taneja N, Rubin E, Kufe DW, Kharbanda SM. Activation of serine/threonine protein kinases and early growth response 1 gene expression by tumor necrosis factor in human myeloid leukemia cells. J Immunol. 1995 Apr 15; 154(8):4150-6.
    View in: PubMed
  290. Yuan ZM, Kharbanda S, Kufe D. 1-beta-D-arabinofuranosylcytosine activates tyrosine phosphorylation of p34cdc2 and its association with the Src-like p56/p53lyn kinase in human myeloid leukemia cells. Biochemistry. 1995 Apr 11; 34(14):4908.
    View in: PubMed
  291. Datta R, Manome Y, Taneja N, Boise LH, Weichselbaum R, Thompson CB, Slapak CA, Kufe D. Overexpression of Bcl-XL by cytotoxic drug exposure confers resistance to ionizing radiation-induced internucleosomal DNA fragmentation. Cell Growth Differ. 1995 Apr; 6(4):363-70.
    View in: PubMed
  292. Chen M, Quintans J, Fuks Z, Thompson C, Kufe DW, Weichselbaum RR. Suppression of Bcl-2 messenger RNA production may mediate apoptosis after ionizing radiation, tumor necrosis factor alpha, and ceramide. Cancer Res. 1995 Mar 1; 55(5):991-4.
    View in: PubMed
  293. Yuan ZM, Kharbanda S, Kufe D. 1-beta-D-arabinofuranosylcytosine activates tyrosine phosphorylation of p34cdc2 and its association with the Src-like p56/p53lyn kinase in human myeloid leukemia cells. Biochemistry. 1995 Jan 24; 34(3):1058-63.
    View in: PubMed
  294. Teicher BA, Menon K, Northey D, Liu J, Kufe DW, Kaddurah-Daouk R. Cyclocreatine in cancer chemotherapy. Cancer Chemother Pharmacol. 1995; 35(5):411-6.
    View in: PubMed
  295. Weichselbaum RR, Beckett MA, Vokes EE, Brachman DG, Haraf D, Hallahan D, Kufe D. Cellular and molecular mechanisms of radioresistance. Cancer Treat Res. 1995; 74:131-40.
    View in: PubMed
  296. Slapak CA, Mizunuma N, Kufe DW. Expression of the multidrug resistance associated protein and P-glycoprotein in doxorubicin-selected human myeloid leukemia cells. Blood. 1994 Nov 1; 84(9):3113-21.
    View in: PubMed
  297. Manome Y, Abe M, Hagen MF, Fine HA, Kufe DW. Enhancer sequences of the DF3 gene regulate expression of the herpes simplex virus thymidine kinase gene and confer sensitivity of human breast cancer cells to ganciclovir. Cancer Res. 1994 Oct 15; 54(20):5408-13.
    View in: PubMed
  298. Kharbanda S, Yuan ZM, Taneja N, Weichselbaum R, Kufe D. p56/p53lyn tyrosine kinase activation in mammalian cells treated with mitomycin C. Oncogene. 1994 Oct; 9(10):3005-11.
    View in: PubMed
  299. Chauhan D, Kharbanda S, Uchiyama H, Urashima M, Fragoso R, Sen J, Kufe DW, Anderson KC. Identification of upstream signals regulating interleukin-6 gene expression during in vitro treatment of human B cells with pokeweed mitogen. Blood. 1994 Oct 1; 84(7):2243-52.
    View in: PubMed
  300. Stone RM, Bernstein SH, Demetri G, Facklam DP, Arthur K, Andersen J, Aster JC, Kufe D. Therapy with recombinant human erythropoietin in patients with myelodysplastic syndromes. Leuk Res. 1994 Oct; 18(10):769-76.
    View in: PubMed
  301. Pantazis P, Mendoza JT, DeJesus A, Rubin E, Kufe D, Giovanella BC. Partial characterization of human leukemia U-937 cell sublines resistant to 9-nitrocamptothecin. Eur J Haematol. 1994 Sep; 53(3):135-44.
    View in: PubMed
  302. Weichselbaum RR, Hallahan D, Fuks Z, Kufe D. Radiation induction of immediate early genes: effectors of the radiation-stress response. Int J Radiat Oncol Biol Phys. 1994 Aug 30; 30(1):229-34.
    View in: PubMed
  303. Weichselbaum RR, Hallahan DE, Beckett MA, Mauceri HJ, Lee H, Sukhatme VP, Kufe DW. Gene therapy targeted by radiation preferentially radiosensitizes tumor cells. Cancer Res. 1994 Aug 15; 54(16):4266-9.
    View in: PubMed
  304. Kharbanda S, Yuan ZM, Rubin E, Weichselbaum R, Kufe D. Activation of Src-like p56/p53lyn tyrosine kinase by ionizing radiation. J Biol Chem. 1994 Aug 12; 269(32):20739-43.
    View in: PubMed
  305. Toppmeyer DL, Slapak CA, Croop J, Kufe DW. Role of P-glycoprotein in dolastatin 10 resistance. Biochem Pharmacol. 1994 Aug 3; 48(3):609-12.
    View in: PubMed
  306. Hallahan DE, Virudachalam S, Kufe DW, Weichselbaum RR. Ketoconazole attenuates radiation-induction of tumor necrosis factor. Int J Radiat Oncol Biol Phys. 1994 Jul 1; 29(4):777-80.
    View in: PubMed
  307. Kharbanda S, Emoto Y, Kisaki H, Saleem A, Kufe D. 1-beta-D-arabinofuranosylcytosine activates serine/threonine protein kinases and c-jun gene expression in phorbol ester-resistant myeloid leukemia cells. Mol Pharmacol. 1994 Jul; 46(1):67-72.
    View in: PubMed
  308. Kharbanda S, Saleem A, Shafman T, Emoto Y, Weichselbaum R, Kufe D. Activation of the pp90rsk and mitogen-activated serine/threonine protein kinases by ionizing radiation. Proc Natl Acad Sci U S A. 1994 Jun 7; 91(12):5416-20.
    View in: PubMed
  309. Hallahan DE, Bleakman D, Virudachalam S, Lee D, Grdina D, Kufe DW, Weichselbaum RR. The role of intracellular calcium in the cellular response to ionizing radiation. Radiat Res. 1994 Jun; 138(3):392-400.
    View in: PubMed
  310. Hallahan DE, Virudachalam S, Kuchibhotla J, Kufe DW, Weichselbaum RR. Membrane-derived second messenger regulates x-ray-mediated tumor necrosis factor alpha gene induction. Proc Natl Acad Sci U S A. 1994 May 24; 91(11):4897-901.
    View in: PubMed
  311. Chauhan D, Kharbanda SM, Uchiyama H, Sukhatme VP, Kufe DW, Anderson KC. Involvement of serum response element in okadaic acid-induced EGR-1 transcription in human T-cells. Cancer Res. 1994 Apr 15; 54(8):2234-9.
    View in: PubMed
  312. Kharbanda S, Saleem A, Datta R, Yuan ZM, Weichselbaum R, Kufe D. Ionizing radiation induces rapid tyrosine phosphorylation of p34cdc2. Cancer Res. 1994 Mar 15; 54(6):1412-4.
    View in: PubMed
  313. Kharbanda S, Saleem A, Hirano M, Emoto Y, Sukhatme V, Blenis J, Kufe D. Activation of early growth response 1 gene transcription and pp90rsk during induction of monocytic differentiation. Cell Growth Differ. 1994 Mar; 5(3):259-65.
    View in: PubMed
  314. Rubin E, Pantazis P, Bharti A, Toppmeyer D, Giovanella B, Kufe D. Identification of a mutant human topoisomerase I with intact catalytic activity and resistance to 9-nitro-camptothecin. J Biol Chem. 1994 Jan 28; 269(4):2433-9.
    View in: PubMed
  315. Yang KD, Mizobuchi T, Kharbanda SM, Datta R, Huberman E, Kufe DW, Stone RM. All-trans retinoic acid reverses phorbol ester resistance in a human myeloid leukemia cell line. Blood. 1994 Jan 15; 83(2):490-6.
    View in: PubMed
  316. Kharbanda S, Saleem A, Emoto Y, Stone R, Rapp U, Kufe D. Activation of Raf-1 and mitogen-activated protein kinases during monocytic differentiation of human myeloid leukemia cells. J Biol Chem. 1994 Jan 14; 269(2):872-8.
    View in: PubMed
  317. Andrews CW, Jessup JM, Goldman H, Hayes DF, Kufe DW, O'Hara CJ, Steele GD. Localization of tumor-associated glycoprotein DF3 in normal, inflammatory, and neoplastic lesions of the colon. Cancer. 1993 Dec 1; 72(11):3185-90.
    View in: PubMed
  318. Manome Y, Datta R, Taneja N, Shafman T, Bump E, Hass R, Weichselbaum R, Kufe D. Coinduction of c-jun gene expression and internucleosomal DNA fragmentation by ionizing radiation. Biochemistry. 1993 Oct 12; 32(40):10607-13.
    View in: PubMed
  319. Kharbanda S, Saleem A, Rubin E, Sukhatme V, Blenis J, Kufe D. Activation of the early growth response 1 gene and nuclear pp90rsk in human myeloid leukemia cells by 1-(beta-D-arabinofuranosyl)cytosine. Biochemistry. 1993 Sep 7; 32(35):9137-42.
    View in: PubMed
  320. Hass R, Hirano M, Kharbanda S, Rubin E, Meinhardt G, Kufe D. Resistance to phorbol ester-induced differentiation of a U-937 myeloid leukemia cell variant with a signaling defect upstream to Raf-1 kinase. Cell Growth Differ. 1993 Aug; 4(8):657-63.
    View in: PubMed
  321. Slapak CA, Kharbanda S, Saleem A, Kufe DW. Defective translocation of protein kinase C in multidrug-resistant HL-60 cells confers a reversible loss of phorbol ester-induced monocytic differentiation. J Biol Chem. 1993 Jun 15; 268(17):12267-73.
    View in: PubMed
  322. Elson CE, Kufe D, Johnston WW. Immunohistochemical detection and significance of axillary lymph node micrometastases in breast carcinoma. A study of 97 cases. Anal Quant Cytol Histol. 1993 Jun; 15(3):171-8.
    View in: PubMed
  323. Kharbanda S, Huberman E, Kufe D. Activation of the jun-D gene during treatment of human myeloid leukemia cells with 1-beta-D-arabinofuranosylcytosine. Biochem Pharmacol. 1993 May 25; 45(10):2055-61.
    View in: PubMed
  324. Stone RM, Spriggs DR, Arthur KA, Mayer RJ, Griffin J, Kufe DW. Recombinant human gamma interferon administered by continuous intravenous infusion in acute myelogenous leukemia and myelodysplastic syndromes. Am J Clin Oncol. 1993 Apr; 16(2):159-63.
    View in: PubMed
  325. Chauhan D, Kharbanda SM, Rubin E, Barut BA, Mohrbacher A, Kufe DW, Anderson KC. Regulation of c-jun gene expression in human T lymphocytes. Blood. 1993 Mar 15; 81(6):1540-8.
    View in: PubMed
  326. Datta R, Taneja N, Sukhatme VP, Qureshi SA, Weichselbaum R, Kufe DW. Reactive oxygen intermediates target CC(A/T)6GG sequences to mediate activation of the early growth response 1 transcription factor gene by ionizing radiation. Proc Natl Acad Sci U S A. 1993 Mar 15; 90(6):2419-22.
    View in: PubMed
  327. Hallahan DE, Gius D, Kuchibhotla J, Sukhatme V, Kufe DW, Weichselbaum RR. Radiation signaling mediated by Jun activation following dissociation from a cell type-specific repressor. J Biol Chem. 1993 Mar 5; 268(7):4903-7.
    View in: PubMed
  328. Hass R, Gunji H, Hirano M, Weichselbaum R, Kufe D. Phorbol ester-induced monocytic differentiation is associated with G2 delay and down-regulation of cdc25 expression. Cell Growth Differ. 1993 Mar; 4(3):159-66.
    View in: PubMed
  329. Kharbanda S, Nakamura T, Kufe D. Induction of the c-jun proto-oncogene by a protein kinase C-dependent mechanism during exposure of human epidermal keratinocytes to ethanol. Biochem Pharmacol. 1993 Feb 9; 45(3):675-81.
    View in: PubMed
  330. Datta R, Weichselbaum R, Kufe DW. Ionizing radiation down-regulates histone H1 gene expression by transcriptional and post-transcriptional mechanisms. Radiat Res. 1993 Feb; 133(2):176-81.
    View in: PubMed
  331. Manome Y, Weichselbaum RR, Kufe DW, Fine HA. Effect of Bcl-2 on ionizing radiation and 1-beta-D-arabinofuranosylcytosine-induced internucleosomal DNA fragmentation and cell survival in human myeloid leukemia cells. Oncol Res. 1993; 5(3):139-44.
    View in: PubMed
  332. Kharbanda S, Rubin E, Datta R, Hass R, Sukhatme V, Kufe D. Transcriptional regulation of the early growth response 1 gene in human myeloid leukemia cells by okadaic acid. Cell Growth Differ. 1993 Jan; 4(1):17-23.
    View in: PubMed
  333. Abe M, Kufe D. Characterization of cis-acting elements regulating transcription of the human DF3 breast carcinoma-associated antigen (MUC1) gene. Proc Natl Acad Sci U S A. 1993 Jan 1; 90(1):282-6.
    View in: PubMed
  334. Hallahan DE, Haimovitz-Friedman A, Kufe DW, Fuks Z, Weichselbaum RR. The role of cytokines in radiation oncology. Important Adv Oncol. 1993; 71-80.
    View in: PubMed
  335. Nakamura T, Lin LL, Kharbanda S, Knopf J, Kufe D. Macrophage colony stimulating factor activates phosphatidylcholine hydrolysis by cytoplasmic phospholipase A2. EMBO J. 1992 Dec; 11(13):4917-22.
    View in: PubMed
  336. Andreeff M, Stone R, Michaeli J, Young CW, Tong WP, Sogoloff H, Ervin T, Kufe D, Rifkind RA, Marks PA. Hexamethylene bisacetamide in myelodysplastic syndrome and acute myelogenous leukemia: a phase II clinical trial with a differentiation-inducing agent. Blood. 1992 Nov 15; 80(10):2604-9.
    View in: PubMed
  337. Perey L, Hayes DF, Kufe D. Effects of differentiating agents on cell surface expression of the breast carcinoma-associated DF3-P epitope. Cancer Res. 1992 Nov 15; 52(22):6365-70.
    View in: PubMed
  338. Datta R, Rubin E, Sukhatme V, Qureshi S, Hallahan D, Weichselbaum RR, Kufe DW. Ionizing radiation activates transcription of the EGR1 gene via CArG elements. Proc Natl Acad Sci U S A. 1992 Nov 1; 89(21):10149-53.
    View in: PubMed
  339. Hass R, Brach M, Gunji H, Kharbanda S, Kufe D. Inhibition of EGR-1 and NF-kappa B gene expression by dexamethasone during phorbol ester-induced human monocytic differentiation. Biochem Pharmacol. 1992 Oct 20; 44(8):1569-76.
    View in: PubMed
  340. Datta R, Hallahan DE, Kharbanda SM, Rubin E, Sherman ML, Huberman E, Weichselbaum RR, Kufe DW. Involvement of reactive oxygen intermediates in the induction of c-jun gene transcription by ionizing radiation. Biochemistry. 1992 Sep 8; 31(35):8300-6.
    View in: PubMed
  341. Datta R, Hass R, Gunji H, Weichselbaum R, Kufe D. Down-regulation of cell cycle control genes by ionizing radiation. Cell Growth Differ. 1992 Sep; 3(9):637-44.
    View in: PubMed
  342. Bernstein SH, Kufe DW. Future of basic/clinical hematopoiesis research in the era of hematopoietic growth factor availability. Semin Oncol. 1992 Aug; 19(4):441-8.
    View in: PubMed
  343. Weichselbaum RR, Beckett MA, Hallahan DE, Kufe DW, Vokes EE. Molecular targets to overcome radioresistance. Semin Oncol. 1992 Aug; 19(4 Suppl 11):14-20.
    View in: PubMed
  344. Schmalbach TK, Datta R, Kufe DW, Sherman ML. Transcriptional regulation of cytokine expression by diethyldithiocarbamate in human HL-60 promyelocytic leukemia cells. Biochem Pharmacol. 1992 Jul 22; 44(2):365-71.
    View in: PubMed
  345. Kharbanda S, Datta R, Rubin E, Nakamura T, Hass R, Kufe D. Regulation of c-jun expression during induction of monocytic differentiation by okadaic acid. Cell Growth Differ. 1992 Jul; 3(7):391-9.
    View in: PubMed
  346. Samet JH, Libman H, Steger KA, Dhawan RK, Chen J, Shevitz AH, Dewees-Dunk R, Levenson S, Kufe D, Craven DE. Compliance with zidovudine therapy in patients infected with human immunodeficiency virus, type 1: a cross-sectional study in a municipal hospital clinic. Am J Med. 1992 May; 92(5):495-502.
    View in: PubMed
  347. Perey L, Hayes DF, Maimonis P, Abe M, O'Hara C, Kufe DW. Tumor selective reactivity of a monoclonal antibody prepared against a recombinant peptide derived from the DF3 human breast carcinoma-associated antigen. Cancer Res. 1992 May 1; 52(9):2563-8.
    View in: PubMed
  348. Brach MA, Herrmann F, Yamada H, Bäuerle PA, Kufe DW. Identification of NF-jun, a novel inducible transcription factor that regulates c-jun gene transcription. EMBO J. 1992 Apr; 11(4):1479-86.
    View in: PubMed
  349. Hass R, Gunji H, Datta R, Kharbanda S, Hartmann A, Weichselbaum R, Kufe D. Differentiation and retrodifferentiation of human myeloid leukemia cells is associated with reversible induction of cell cycle-regulatory genes. Cancer Res. 1992 Mar 15; 52(6):1445-50.
    View in: PubMed
  350. Gunji H, Hass R, Kufe D. Internucleosomal DNA fragmentation during phorbol ester-induced monocytic differentiation and G0/G1 arrest. J Clin Invest. 1992 Mar; 89(3):954-60.
    View in: PubMed
  351. Datta R, Imamura K, Goldman SJ, Dianoux AC, Kufe DW, Sherman ML. Functional expression of the macrophage colony-stimulating factor receptor in human THP-1 monocytic leukemia cells. Blood. 1992 Feb 15; 79(4):904-12.
    View in: PubMed
  352. Rubin E, Kharbanda S, Gunji H, Weichselbaum R, Kufe D. cis-Diamminedichloroplatinum(II) induces c-jun expression in human myeloid leukemia cells: potential involvement of a protein kinase C-dependent signaling pathway. Cancer Res. 1992 Feb 15; 52(4):878-82.
    View in: PubMed
  353. Clinton SK, Underwood R, Hayes L, Sherman ML, Kufe DW, Libby P. Macrophage colony-stimulating factor gene expression in vascular cells and in experimental and human atherosclerosis. Am J Pathol. 1992 Feb; 140(2):301-16.
    View in: PubMed
  354. Brach MA, Herrmann F, Kufe DW. Activation of the AP-1 transcription factor by arabinofuranosylcytosine in myeloid leukemia cells. Blood. 1992 Feb 1; 79(3):728-34.
    View in: PubMed
  355. Spriggs DR, Deutsch S, Kufe DW. Genomic structure, induction, and production of TNF-alpha. Immunol Ser. 1992; 56:3-34.
    View in: PubMed
  356. Pruzanski W, Sherman ML, Kufe DW, Vadas P. Induction of circulating phospholipase A(2) by intravenous administration of recombinant human tumour necrosis factor. Mediators Inflamm. 1992; 1(4):235-40.
    View in: PubMed
  357. Weichselbaum RR, Hallahan DE, Sukhatme VP, Kufe DW. Gene therapy targeted by ionizing radiation. Int J Radiat Oncol Biol Phys. 1992; 24(3):565-7.
    View in: PubMed
  358. Damstrup L, Andersen J, Kufe DW, Hayes DF, Poulsen HS. Immunocytochemical determination of the estrogen-regulated proteins Mr 24,000, Mr 52,000 and DF3 breast cancer associated antigen: clinical value in advanced breast cancer and correlation with estrogen receptor. Ann Oncol. 1992 Jan; 3(1):71-7.
    View in: PubMed
  359. Datta R, Kharbanda S, Kufe DW. Transcriptional and posttranscriptional regulation of H1 histone gene expression by 1-beta-D-arabinofuranosylcytosine. Mol Pharmacol. 1992 Jan; 41(1):64-8.
    View in: PubMed
  360. Brach MA, Kharbanda SM, Herrmann F, Kufe DW. Activation of the transcription factor kappa B in human KG-1 myeloid leukemia cells treated with 1-beta-D-arabinofuranosylcytosine. Mol Pharmacol. 1992 Jan; 41(1):60-3.
    View in: PubMed
  361. Kharbanda S, Rubin E, Gunji H, Hinz H, Giovanella B, Pantazis P, Kufe D. Camptothecin and its derivatives induce expression of the c-jun protooncogene in human myeloid leukemia cells. Cancer Res. 1991 Dec 15; 51(24):6636-42.
    View in: PubMed
  362. Bernstein SH, Kharbanda SM, Sherman ML, Stone RM, Kufe DW. Inhibition of protein kinase C is associated with a decrease in c-myc expression in human myeloid leukemia cells. FEBS Lett. 1991 Dec 2; 294(1-2):73-6.
    View in: PubMed
  363. Ohno T, Terada M, Yoneda Y, Shea KW, Chambers RF, Stroka DM, Nakamura M, Kufe DW. A broadly neutralizing monoclonal antibody that recognizes the V3 region of human immunodeficiency virus type 1 glycoprotein gp120. Proc Natl Acad Sci U S A. 1991 Dec 1; 88(23):10726-9.
    View in: PubMed
  364. Hallahan DE, Virudachalam S, Beckett M, Sherman ML, Kufe D, Weichselbaum RR. Mechanisms of X-ray-mediated protooncogene c-jun expression in radiation-induced human sarcoma cell lines. Int J Radiat Oncol Biol Phys. 1991 Nov; 21(6):1677-81.
    View in: PubMed
  365. Hass R, Pfannkuche HJ, Kharbanda S, Gunji H, Meyer G, Hartmann A, Hidaka H, Resch K, Kufe D, Goppelt-Strübe M. Protein kinase C activation and protooncogene expression in differentiation/retrodifferentiation of human U-937 leukemia cells. Cell Growth Differ. 1991 Nov; 2(11):541-8.
    View in: PubMed
  366. Yamada H, Iwase S, Mohri M, Kufe D. Involvement of a nuclear factor-kappa B-like protein in induction of the macrophage colony-stimulating factor gene by tumor necrosis factor. Blood. 1991 Oct 15; 78(8):1988-95.
    View in: PubMed
  367. Hass R, Brach M, Kharbanda S, Giese G, Traub P, Kufe D. Inhibition of phorbol ester-induced monocytic differentiation by dexamethasone is associated with down-regulation of c-fos and c-jun (AP-1). J Cell Physiol. 1991 Oct; 149(1):125-31.
    View in: PubMed
  368. Hallahan DE, Virudachalam S, Sherman ML, Huberman E, Kufe DW, Weichselbaum RR. Tumor necrosis factor gene expression is mediated by protein kinase C following activation by ionizing radiation. Cancer Res. 1991 Sep 1; 51(17):4565-9.
    View in: PubMed
  369. Takeyama H, Wakamiya N, O'Hara C, Arthur K, Niloff J, Kufe D, Sakarai K, Spriggs D. Tumor necrosis factor expression by human ovarian carcinoma in vivo. Cancer Res. 1991 Aug 15; 51(16):4476-80.
    View in: PubMed
  370. Kharbanda S, Datta R, Kufe D. Regulation of c-jun gene expression in HL-60 leukemia cells by 1-beta-D-arabinofuranosylcytosine. Potential involvement of a protein kinase C dependent mechanism. Biochemistry. 1991 Aug 13; 30(32):7947-52.
    View in: PubMed
  371. Kharbanda S, Nakamura T, Stone R, Hass R, Bernstein S, Datta R, Sukhatme VP, Kufe D. Expression of the early growth response 1 and 2 zinc finger genes during induction of monocytic differentiation. J Clin Invest. 1991 Aug; 88(2):571-7.
    View in: PubMed
  372. Brach MA, Hass R, Sherman ML, Gunji H, Weichselbaum R, Kufe D. Ionizing radiation induces expression and binding activity of the nuclear factor kappa B. J Clin Invest. 1991 Aug; 88(2):691-5.
    View in: PubMed
  373. Maimonis P, Hayes DF, Schaffel S, Kufe D. Lung cancer-associated protein: development and characterization of a new assay that detects a circulating lung cancer marker. Cancer Res. 1991 Aug 1; 51(15):3838-42.
    View in: PubMed
  374. Bernstein SH, Sherman ML, Hass R, Nakamura T, Kharbanda S, Kufe DW. Effects of hexamethylene bisacetamide on induction of monocytic differentiation of human U-937 myeloid leukemia cells. Biochem Pharmacol. 1991 Jul 5; 42(2):403-7.
    View in: PubMed
  375. Datta R, Nakamura T, Sherman ML, Kufe D. Regulation of jun-B expression by a cyclic AMP (cAMP)-dependent mechanism in human myeloid cells. Blood. 1991 Jul 1; 78(1):83-8.
    View in: PubMed
  376. Rubin E, Kharbanda S, Gunji H, Kufe D. Activation of the c-jun protooncogene in human myeloid leukemia cells treated with etoposide. Mol Pharmacol. 1991 Jun; 39(6):697-701.
    View in: PubMed
  377. Nakamura T, Datta R, Kharbanda S, Kufe D. Regulation of jun and fos gene expression in human monocytes by the macrophage colony-stimulating factor. Cell Growth Differ. 1991 Jun; 2(6):267-72.
    View in: PubMed
  378. Bernstein SH, Kharbanda SM, Sherman ML, Sukhatme VP, Kufe DW. Posttranscriptional regulation of the zinc finger-encoding EGR-1 gene by granulocyte-macrophage colony-stimulating factor in human U-937 monocytic leukemia cells: involvement of a pertussis toxin-sensitive G protein. Cell Growth Differ. 1991 Jun; 2(6):273-8.
    View in: PubMed
  379. Chambers RF, Terada M, Kufe D, Ohno T. Shaking HIV-1 infected cells indicates novel behavior of MN strain. AIDS Res Hum Retroviruses. 1991 May; 7(5):459-63.
    View in: PubMed
  380. Sherman ML, Datta R, Hallahan DE, Weichselbaum RR, Kufe DW. Regulation of tumor necrosis factor gene expression by ionizing radiation in human myeloid leukemia cells and peripheral blood monocytes. J Clin Invest. 1991 May; 87(5):1794-7.
    View in: PubMed
  381. Weichselbaum RR, Hallahan DE, Sukhatme V, Dritschilo A, Sherman ML, Kufe DW. Biological consequences of gene regulation after ionizing radiation exposure. J Natl Cancer Inst. 1991 Apr 3; 83(7):480-4.
    View in: PubMed
  382. Hallahan DE, Sukhatme VP, Sherman ML, Virudachalam S, Kufe D, Weichselbaum RR. Protein kinase C mediates x-ray inducibility of nuclear signal transducers EGR1 and JUN. Proc Natl Acad Sci U S A. 1991 Mar 15; 88(6):2156-60.
    View in: PubMed
  383. Pantazis P, Kharbanda S, Goustin AS, Galanopoulos T, Kufe D. Coexpression of the genes for platelet-derived growth factor B-chain receptor and macrophage colony-stimulating factor 1 receptor during monocytic differentiation. Proc Natl Acad Sci U S A. 1991 Mar 15; 88(6):2481-5.
    View in: PubMed
  384. Gunji H, Kharbanda S, Kufe D. Induction of internucleosomal DNA fragmentation in human myeloid leukemia cells by 1-beta-D-arabinofuranosylcytosine. Cancer Res. 1991 Jan 15; 51(2):741-3.
    View in: PubMed
  385. Brach M, Stone R, Kufe D. CSFs in combination with cytosine arabinoside, an inhibitor of DNA synthesis: potential strategies for the treatment of myeloid disorders. Biotechnol Ther. 1991; 2(3-4):269-83.
    View in: PubMed
  386. Datta R, Sherman ML, Stone RM, Kufe D. Expression of the jun-B gene during induction of monocytic differentiation. Cell Growth Differ. 1991 Jan; 2(1):43-9.
    View in: PubMed
  387. Nakamura T, Datta R, Sherman ML, Kufe D. Regulation of c-jun gene expression by cAMP in HL-60 myeloid leukemia cells. J Biol Chem. 1990 Dec 15; 265(35):22011-5.
    View in: PubMed
  388. Dhawan RK, Kharbanda S, Nakamura M, Ohno T, Kufe D. Effects of granulocyte-macrophage colony-stimulating factor on 3'-azido-3'-deoxythymidine uptake, phosphorylation and nucleotide retention in human U-937 cells. Biochem Pharmacol. 1990 Dec 15; 40(12):2695-700.
    View in: PubMed
  389. Stone RM, Spriggs DR, Dhawan RK, Arthur KA, Mayer RJ, Kufe DW. A phase I study of intermittent continuous infusion high dose cytosine arabinoside for acute leukemia. Leukemia. 1990 Dec; 4(12):843-7.
    View in: PubMed
  390. Spriggs DR, Sherman ML, Imamura K, Mohri M, Rodriguez C, Robbins G, Kufe DW. Phospholipase A2 activation and autoinduction of tumor necrosis factor gene expression by tumor necrosis factor. Cancer Res. 1990 Nov 15; 50(22):7101-7.
    View in: PubMed
  391. Kharbanda SM, Sherman ML, Kufe DW. Transcriptional regulation of c-jun gene expression by arabinofuranosylcytosine in human myeloid leukemia cells. J Clin Invest. 1990 Nov; 86(5):1517-23.
    View in: PubMed
  392. Maimonis P, Hayes DF, O'Hara C, Kufe D. Detection and characterization of a high molecular weight human lung carcinoma-associated glycoprotein. Cancer Res. 1990 Oct 15; 50(20):6738-43.
    View in: PubMed
  393. Datta R, Kharbanda S, Kufe D. Regulation of jun-B gene expression by 1-beta-D-arabinofuranosyl-cytosine in human myeloid leukemia cells. Mol Pharmacol. 1990 Oct; 38(4):435-9.
    View in: PubMed
  394. Stone RM, Imamura K, Datta R, Sherman ML, Kufe DW. Inhibition of phorbol ester-induced monocytic differentiation and c-fms gene expression by dexamethasone: potential involvement of arachidonic acid metabolites. Blood. 1990 Sep 15; 76(6):1225-32.
    View in: PubMed
  395. Imamura K, Dianoux A, Nakamura T, Kufe D. Colony-stimulating factor 1 activates protein kinase C in human monocytes. EMBO J. 1990 Aug; 9(8):2423-8, 2389.
    View in: PubMed
  396. Sherman ML, Datta R, Hallahan DE, Weichselbaum RR, Kufe DW. Ionizing radiation regulates expression of the c-jun protooncogene. Proc Natl Acad Sci U S A. 1990 Aug; 87(15):5663-6.
    View in: PubMed
  397. Hayes DF, Silberstein DS, Rodrique SW, Kufe DW. DF3 antigen, a human epithelial cell mucin, inhibits adhesion of eosinophils to antibody-coated targets. J Immunol. 1990 Aug 1; 145(3):962-70.
    View in: PubMed
  398. Datta R, Sherman ML, Kufe DW. Regulation of proto-oncogene and tumor necrosis factor gene expression by ethanol in HL-60 myeloid leukemia cells. Blood. 1990 Jul 15; 76(2):298-301.
    View in: PubMed
  399. Hallahan DE, Beckett MA, Kufe D, Weichselbaum RR. The interaction between recombinant human tumor necrosis factor and radiation in 13 human tumor cell lines. Int J Radiat Oncol Biol Phys. 1990 Jul; 19(1):69-74.
    View in: PubMed
  400. Abe M, Kufe D. Transcriptional regulation of DF3 gene expression in human MCF-7 breast carcinoma cells. J Cell Physiol. 1990 May; 143(2):226-31.
    View in: PubMed
  401. Mohri M, Spriggs DR, Kufe D. Effects of lipopolysaccharide on phospholipase A2 activity and tumor necrosis factor expression in HL-60 cells. J Immunol. 1990 Apr 1; 144(7):2678-82.
    View in: PubMed
  402. Sherman ML, Stone RM, Datta R, Bernstein SH, Kufe DW. Transcriptional and post-transcriptional regulation of c-jun expression during monocytic differentiation of human myeloid leukemic cells. J Biol Chem. 1990 Feb 25; 265(6):3320-3.
    View in: PubMed
  403. Tondini C, Pap SA, Hayes DF, Elias AD, Kufe DW. Evaluation of monoclonal antibody DF3 conjugated with ricin as a specific immunotoxin for in vitro purging of human bone marrow. Cancer Res. 1990 Feb 15; 50(4):1170-5.
    View in: PubMed
  404. Sherman ML, Weber BL, Datta R, Kufe DW. Transcriptional and posttranscriptional regulation of macrophage-specific colony stimulating factor gene expression by tumor necrosis factor. Involvement of arachidonic acid metabolites. J Clin Invest. 1990 Feb; 85(2):442-7.
    View in: PubMed
  405. Nakamura T, Kharbanda S, Spriggs D, Kufe D. Effects of dexamethasone on induction of monocytic differentiation in human U-937 cells by dimethylsulfoxide. J Cell Physiol. 1990 Feb; 142(2):261-7.
    View in: PubMed
  406. Kharbanda SM, Sherman ML, Kufe DW. Effects of tiazofurin on guanine nucleotide binding regulatory proteins in HL-60 cells. Blood. 1990 Feb 1; 75(3):583-8.
    View in: PubMed
  407. Kharbanda S, Datta R, Kufe D. Induction of c-fos gene expression by arabinofuranosylcytosine in human KG-1 leukemia cells. Cancer Commun. 1990; 2(12):409-14.
    View in: PubMed
  408. Kharbanda S, Nakamura T, Datta R, Sherman ML, Kufe D. Induction of monocytic differentiation by tumor necrosis factor in phorbol ester-resistant KG-1a cells. Cancer Commun. 1990; 2(10):327-32.
    View in: PubMed
  409. Merlo GR, Siddiqui J, Cropp CS, Liscia DS, Lidereau R, Callahan R, Kufe DW. Frequent alteration of the DF3 tumor-associated antigen gene in primary human breast carcinomas. Cancer Res. 1989 Dec 15; 49(24 Pt 1):6966-71.
    View in: PubMed
  410. Abe M, Siddiqui J, Kufe D. Sequence analysis of the 5' region of the human DF3 breast carcinoma-associated antigen gene. Biochem Biophys Res Commun. 1989 Dec 15; 165(2):644-9.
    View in: PubMed
  411. Hallahan DE, Spriggs DR, Beckett MA, Kufe DW, Weichselbaum RR. Increased tumor necrosis factor alpha mRNA after cellular exposure to ionizing radiation. Proc Natl Acad Sci U S A. 1989 Dec; 86(24):10104-7.
    View in: PubMed
  412. Tondini C, Hayes DF, Kufe DW. Circulating tumor markers in breast cancer. Hematol Oncol Clin North Am. 1989 Dec; 3(4):653-74.
    View in: PubMed
  413. Demetri GD, Spriggs DR, Sherman ML, Arthur KA, Imamura K, Kufe DW. A phase I trial of recombinant human tumor necrosis factor and interferon-gamma: effects of combination cytokine administration in vivo. J Clin Oncol. 1989 Oct; 7(10):1545-53.
    View in: PubMed
  414. Sariban E, Imamura K, Sherman M, Rothwell V, Pantazis P, Kufe D. Downregulation of c-fms gene expression in human monocytes treated with phorbol esters and colony-stimulating factor 1. Blood. 1989 Jul; 74(1):123-9.
    View in: PubMed
  415. Brouckaert P, Spriggs DR, Demetri G, Kufe DW, Fiers W. Circulating interleukin 6 during a continuous infusion of tumor necrosis factor and interferon gamma. J Exp Med. 1989 Jun 1; 169(6):2257-62.
    View in: PubMed
  416. Abe M, Kufe D. Structural analysis of the DF3 human breast carcinoma-associated protein. Cancer Res. 1989 Jun 1; 49(11):2834-9.
    View in: PubMed
  417. Imamura K, Spriggs D, Ohno T, Kufe D. Effects of botulinum toxin type D on secretion of tumor necrosis factor from human monocytes. Mol Cell Biol. 1989 May; 9(5):2239-43.
    View in: PubMed
  418. Ohno Y, Spriggs D, Matsukage A, Ohno T, Kufe D. Sequence-specific inhibition of DNA strand elongation by incorporation of 9-beta-D-arabinofuranosyladenine. Cancer Res. 1989 Apr 15; 49(8):2077-81.
    View in: PubMed
  419. Sherman ML, Shafman TD, Colman MS, Kufe DW. Tiazofurin induction of mouse erythroleukemia cell hemoglobin production in the absence of commitment or changes in protooncogene expression. Blood. 1989 Feb; 73(2):431-4.
    View in: PubMed
  420. Weber B, Horiguchi J, Luebbers R, Sherman M, Kufe D. Posttranscriptional stabilization of c-fms mRNA by a labile protein during human monocytic differentiation. Mol Cell Biol. 1989 Feb; 9(2):769-75.
    View in: PubMed
  421. Wakamiya N, Stone R, Takeyama H, Spriggs D, Kufe D. Detection of tumor necrosis factor gene expression at a cellular level in human acute myeloid leukemias. Leukemia. 1989 Jan; 3(1):51-6.
    View in: PubMed
  422. Horiguchi J, Spriggs D, Imamura K, Stone R, Luebbers R, Kufe D. Role of arachidonic acid metabolism in transcriptional induction of tumor necrosis factor gene expression by phorbol ester. Mol Cell Biol. 1989 Jan; 9(1):252-8.
    View in: PubMed
  423. Kharbanda SM, Miyazaki K, Takeyama H, Sherman ML, Spriggs DR, Carney WP, Kufe DW. Effects of tiazofurin on globin and proto-oncogene expression in K562 erythroleukemia cells. Cancer Commun. 1989; 1(3):191-7.
    View in: PubMed
  424. Hull SR, Bright A, Carraway KL, Abe M, Hayes DF, Kufe DW. Oligosaccharide differences in the DF3 sialomucin antigen from normal human milk and the BT-20 human breast carcinoma cell line. Cancer Commun. 1989; 1(4):261-7.
    View in: PubMed
  425. Horiguchi J, Sherman ML, Sampson-Johannes A, Weber BL, Kufe DW. CSF-1 and C-FMS gene expression in human carcinoma cell lines. Biochem Biophys Res Commun. 1988 Nov 30; 157(1):395-401.
    View in: PubMed
  426. Kharbanda SM, Sherman ML, Spriggs DR, Kufe DW. Effects of tiazofurin on protooncogene expression during HL-60 cell differentiation. Cancer Res. 1988 Nov 1; 48(21):5965-8.
    View in: PubMed
  427. Imamura K, Kufe D. Colony-stimulating factor 1-induced Na+ influx into human monocytes involves activation of a pertussis toxin-sensitive GTP-binding protein. J Biol Chem. 1988 Oct 5; 263(28):14093-8.
    View in: PubMed
  428. Sariban E, Sitaras NM, Antoniades HN, Kufe DW, Pantazis P. Expression of platelet-derived growth factor (PDGF)-related transcripts and synthesis of biologically active PDGF-like proteins by human malignant epithelial cell lines. J Clin Invest. 1988 Oct; 82(4):1157-64.
    View in: PubMed
  429. Spriggs DR, Sherman ML, Michie H, Arthur KA, Imamura K, Wilmore D, Frei E, Kufe DW. Recombinant human tumor necrosis factor administered as a 24-hour intravenous infusion. A phase I and pharmacologic study. J Natl Cancer Inst. 1988 Sep 7; 80(13):1039-44.
    View in: PubMed
  430. Horiguchi J, Sariban E, Kufe D. Transcriptional and posttranscriptional regulation of CSF-1 gene expression in human monocytes. Mol Cell Biol. 1988 Sep; 8(9):3951-4.
    View in: PubMed
  431. Sariban E, Kufe D. Expression of the platelet-derived growth factor 1 and 2 genes in human myeloid cell lines and monocytes. Cancer Res. 1988 Aug 15; 48(16):4498-502.
    View in: PubMed
  432. Stone RM, Weber BL, Spriggs DR, Kufe DW. Phospholipase C activates protein kinase C and induces monocytic differentiation of HL-60 cells. Blood. 1988 Aug; 72(2):739-44.
    View in: PubMed
  433. Imamura K, Sherman ML, Spriggs D, Kufe D. Effect of tumor necrosis factor on GTP binding and GTPase activity in HL-60 and L929 cells. J Biol Chem. 1988 Jul 25; 263(21):10247-53.
    View in: PubMed
  434. Tondini C, Hayes DF, Gelman R, Henderson IC, Kufe DW. Comparison of CA15-3 and carcinoembryonic antigen in monitoring the clinical course of patients with metastatic breast cancer. Cancer Res. 1988 Jul 15; 48(14):4107-12.
    View in: PubMed
  435. Stone RM, Sariban E, Pettit GR, Kufe DW. Bryostatin 1 activates protein kinase C and induces monocytic differentiation of HL-60 cells. Blood. 1988 Jul; 72(1):208-13.
    View in: PubMed
  436. Thor A, Viglione MJ, Ohuchi N, Simpson J, Steis R, Cousar J, Lippman M, Kufe DW, Schlom J. Comparison of monoclonal antibodies for the detection of occult breast carcinoma metastases in bone marrow. Breast Cancer Res Treat. 1988 May; 11(2):133-45.
    View in: PubMed
  437. Spriggs DR, Robbins G, Arthur K, Mayer RJ, Kufe D. Prolonged high dose ARA-C infusions in acute leukemia. Leukemia. 1988 May; 2(5):304-6.
    View in: PubMed
  438. Sariban E, Imamura K, Luebbers R, Kufe D. Transcriptional and posttranscriptional regulation of tumor necrosis factor gene expression in human monocytes. J Clin Invest. 1988 May; 81(5):1506-10.
    View in: PubMed
  439. Siddiqui J, Abe M, Hayes D, Shani E, Yunis E, Kufe D. Isolation and sequencing of a cDNA coding for the human DF3 breast carcinoma-associated antigen. Proc Natl Acad Sci U S A. 1988 Apr; 85(7):2320-3.
    View in: PubMed
  440. Rambaldi A, Wakamiya N, Vellenga E, Horiguchi J, Warren MK, Kufe D, Griffin JD. Expression of the macrophage colony-stimulating factor and c-fms genes in human acute myeloblastic leukemia cells. J Clin Invest. 1988 Apr; 81(4):1030-5.
    View in: PubMed
  441. Ohno Y, Spriggs D, Matsukage A, Ohno T, Kufe D. Effects of 1-beta-D-arabinofuranosylcytosine incorporation on elongation of specific DNA sequences by DNA polymerase beta. Cancer Res. 1988 Mar 15; 48(6):1494-8.
    View in: PubMed
  442. Sherman ML, Shafman TD, Kufe DW. Modulation of cyclic AMP levels and differentiation by adenosine analogs in mouse erythroleukemia cells. J Cell Physiol. 1988 Mar; 134(3):429-36.
    View in: PubMed
  443. Sherman ML, Spriggs DR, Arthur KA, Imamura K, Frei E, Kufe DW. Recombinant human tumor necrosis factor administered as a five-day continuous infusion in cancer patients: phase I toxicity and effects on lipid metabolism. J Clin Oncol. 1988 Feb; 6(2):344-50.
    View in: PubMed
  444. Hayes DF, Sekine H, Marcus D, Alper CA, Kufe DW. Genetically determined polymorphism of the circulating human breast cancer-associated DF3 antigen. Blood. 1988 Feb; 71(2):436-40.
    View in: PubMed
  445. Spriggs DR, Imamura K, Rodriguez C, Sariban E, Kufe DW. Tumor necrosis factor expression in human epithelial tumor cell lines. J Clin Invest. 1988 Feb; 81(2):455-60.
    View in: PubMed
  446. Sariban E, Mitchell T, Rambaldi A, Kufe DW. c-sis but not c-fos gene expression is lineage specific in human myeloid cells. Blood. 1988 Feb; 71(2):488-93.
    View in: PubMed
  447. Hayes DF, Noska MA, Kufe DW, Zalutsky MR. Effect of radioiodination on the binding of monoclonal antibody DF3 to breast carcinoma cells. Int J Rad Appl Instrum B. 1988; 15(3):235-41.
    View in: PubMed
  448. Sariban E, Luebbers R, Kufe D. Transcriptional and posttranscriptional control of c-fos gene expression in human monocytes. Mol Cell Biol. 1988 Jan; 8(1):340-6.
    View in: PubMed
  449. Spriggs D, Robbins G, Ohno Y, Kufe D. Detection of 1-beta-D-arabinofuranosylcytosine incorporation into DNA in vivo. Cancer Res. 1987 Dec 15; 47(24 Pt 1):6532-6.
    View in: PubMed
  450. Imamura K, Spriggs D, Kufe D. Expression of tumor necrosis factor receptors on human monocytes and internalization of receptor bound ligand. J Immunol. 1987 Nov 1; 139(9):2989-92.
    View in: PubMed
  451. Spriggs D, Imamura K, Rodriguez C, Horiguchi J, Kufe DW. Induction of tumor necrosis factor expression and resistance in a human breast tumor cell line. Proc Natl Acad Sci U S A. 1987 Sep; 84(18):6563-6.
    View in: PubMed
  452. Abe M, Kufe DW. Identification of a family of high molecular weight tumor-associated glycoproteins. J Immunol. 1987 Jul 1; 139(1):257-61.
    View in: PubMed
  453. Ohuchi N, Page DL, Merino MJ, Viglione MJ, Kufe DW, Schlom J. Expression of tumor-associated antigen (DF3) in atypical hyperplasias and in situ carcinomas of the human breast. J Natl Cancer Inst. 1987 Jul; 79(1):109-17.
    View in: PubMed
  454. Kufe DW, Spriggs DR, Griffin JD. Pharmacologic studies of low-dose and high-dose continuous infusion cytosine arabinoside. Semin Oncol. 1987 Jun; 14(2 Suppl 1):149-58.
    View in: PubMed
  455. Cannistra SA, Rambaldi A, Spriggs DR, Herrmann F, Kufe D, Griffin JD. Human granulocyte-macrophage colony-stimulating factor induces expression of the tumor necrosis factor gene by the U937 cell line and by normal human monocytes. J Clin Invest. 1987 Jun; 79(6):1720-8.
    View in: PubMed
  456. Wakamiya N, Horiguchi J, Kufe D. Detection of c-fms and CSF-1 RNA by in situ hybridization. Leukemia. 1987 Jun; 1(6):518-20.
    View in: PubMed
  457. Sariban E, Mitchell T, Kufe D. Expression of the c-raf protooncogene in human hematopoietic cells and cell lines. Blood. 1987 May; 69(5):1437-40.
    View in: PubMed
  458. Lundy J, Mishriki Y, Varma AO, Kufe D, Schuss A. Tumor-associated antigens in bilateral breast cancer. J Surg Oncol. 1987 May; 35(1):24-9.
    View in: PubMed
  459. Horiguchi J, Warren MK, Kufe D. Expression of the macrophage-specific colony-stimulating factor in human monocytes treated with granulocyte-macrophage colony-stimulating factor. Blood. 1987 Apr; 69(4):1259-61.
    View in: PubMed
  460. Sariban E, Mitchell T, Griffin J, Kufe DW. Effects of interferon-gamma on proto-oncogene expression during induction of human monocytic differentiation. J Immunol. 1987 Mar 15; 138(6):1954-8.
    View in: PubMed
  461. Band H, Corredor V, Lustgarten J, Huebner K, Griffin JD, Kufe DW, Yunis EJ. Southern blot analysis of BII cell line--a putative variant of HL-60. Leukemia. 1987 Feb; 1(2):142-5.
    View in: PubMed
  462. Spriggs DR, Sherman ML, Frei E, Kufe DW. Clinical studies with tumour necrosis factor. Ciba Found Symp. 1987; 131:206-27.
    View in: PubMed
  463. Horiguchi J, Warren MK, Ralph P, Kufe D. Expression of the macrophage specific colony-stimulating factor (CSF-1) during human monocytic differentiation. Biochem Biophys Res Commun. 1986 Dec 30; 141(3):924-30.
    View in: PubMed
  464. Spriggs DR, Robbins G, Kufe DW. Effects of cis-diamminedichloroplatinum on DNA incorporation and cytotoxicity of 1-beta-D-arabinofuranosylcytosine. Biochem Pharmacol. 1986 Dec 1; 35(23):4297-302.
    View in: PubMed
  465. Spriggs DR, Stopa E, Mayer RJ, Schoene W, Kufe DW. Fludarabine phosphate (NSC 312878) infusions for the treatment of acute leukemia: phase I and neuropathological study. Cancer Res. 1986 Nov; 46(11):5953-8.
    View in: PubMed
  466. Spriggs DR, Stone RM, Kufe DW. The treatment of myelodysplastic syndromes. Clin Haematol. 1986 Nov; 15(4):1081-107.
    View in: PubMed
  467. Mitchell T, Sariban E, Kufe D. Effects of 1-beta-D-arabinofuranosylcytosine on proto-oncogene expression in human U-937 cells. Mol Pharmacol. 1986 Oct; 30(4):398-402.
    View in: PubMed
  468. Hayes DF, Zurawski VR, Kufe DW. Comparison of circulating CA15-3 and carcinoembryonic antigen levels in patients with breast cancer. J Clin Oncol. 1986 Oct; 4(10):1542-50.
    View in: PubMed
  469. Friedman EL, Hayes DF, Kufe DW. Reactivity of monoclonal antibody DF3 with a high molecular weight antigen expressed in human ovarian carcinomas. Cancer Res. 1986 Oct; 46(10):5189-94.
    View in: PubMed
  470. Pantazis P, Sariban E, Kufe D, Antoniades HN. Induction of c-sis gene expression and synthesis of platelet-derived growth factor in human myeloid leukemia cells during monocytic differentiation. Proc Natl Acad Sci U S A. 1986 Sep; 83(17):6455-9.
    View in: PubMed
  471. Kaysen J, Spriggs D, Kufe D. Incorporation of 5-fluorodeoxycytidine and metabolites into nucleic acids of human MCF-7 breast carcinoma cells. Cancer Res. 1986 Sep; 46(9):4534-8.
    View in: PubMed
  472. Sherman ML, Shafman TD, Coward JK, Kufe DW. Selective inhibition of spermidine biosynthesis and differentiation by S-adenosyl-1,8-diamino-3-thiooctane in murine erythroleukemia cells. Biochem Pharmacol. 1986 Aug 1; 35(15):2633-6.
    View in: PubMed
  473. Hayes DF, Zalutsky MR, Kaplan W, Noska M, Thor A, Colcher D, Kufe DW. Pharmacokinetics of radiolabeled monoclonal antibody B6.2 in patients with metastatic breast cancer. Cancer Res. 1986 Jun; 46(6):3157-63.
    View in: PubMed
  474. Watanabe T, Sherman M, Shafman T, Iwata T, Kufe D. Effects of ornithine decarboxylase inhibition on c-myc expression during murine erythroleukemia cell proliferation and differentiation. J Cell Physiol. 1986 Jun; 127(3):480-4.
    View in: PubMed
  475. Iwata T, Watanabe T, Kufe DW. Effects of 5-fluorouracil on globin mRNA synthesis in murine erythroleukemia cells. Biochemistry. 1986 May 6; 25(9):2703-7.
    View in: PubMed
  476. Sherman ML, Shafman TD, Kufe DW. Inhibitory effects of theophylline and dibutyryl cAMP on murine erythroleukemia cell differentiation. Biochem Biophys Res Commun. 1986 Jan 29; 134(2):845-51.
    View in: PubMed
  477. Spriggs D, Robbins G, Mitchell T, Kufe D. Incorporation of 9-beta-D-arabinofuranosyl-2-fluoroadenine into HL-60 cellular RNA and DNA. Biochem Pharmacol. 1986 Jan 15; 35(2):247-52.
    View in: PubMed
  478. Abe M, Kufe D. Effects of maturational agents on expression and secretion of two partially characterized high molecular weight milk-related glycoproteins in MCF-7 breast carcinoma cells. J Cell Physiol. 1986 Jan; 126(1):126-32.
    View in: PubMed
  479. Spriggs DR, Sokal JE, Griffin J, Kufe DW. Low dose ara-C administered by continuous subcutaneous infusion: a pharmacologic evaluation. Cancer Drug Deliv. 1986; 3(3):211-6.
    View in: PubMed
  480. Sherman ML, Shafman TD, Spriggs DR, Kufe DW. Inhibition of murine erythroleukemia cell differentiation by 3-deazaadenosine. Cancer Res. 1985 Nov; 45(11 Pt 2):5830-4.
    View in: PubMed
  481. Sekine H, Ohno T, Kufe DW. Purification and characterization of a high molecular weight glycoprotein detectable in human milk and breast carcinomas. J Immunol. 1985 Nov; 135(5):3610-5.
    View in: PubMed
  482. Griffin JD, Larcom P, Kufe DW. TPA induces differentiation of purified human myeloblasts in the absence of proliferation. Exp Hematol. 1985 Nov; 13(10):1025-32.
    View in: PubMed
  483. Sekine H, Hayes DF, Ohno T, Keefe KA, Schaetzl E, Bast RC, Knapp R, Kufe DW. Circulating DF3 and CA125 antigen levels in serum from patients with epithelial ovarian carcinoma. J Clin Oncol. 1985 Oct; 3(10):1355-63.
    View in: PubMed
  484. Spriggs DR, Robbins G, Takvorian T, Kufe DW. Continuous infusion of high-dose 1-beta-D-arabinofuranosylcytosine: a phase I and pharmacological study. Cancer Res. 1985 Aug; 45(8):3932-6.
    View in: PubMed
  485. Fram RJ, Kufe DW. Effect of 1-beta-D-arabinofuranosyl cytosine and hydroxyurea on the repair of X-ray-induced DNA single-strand breaks in human leukemic blasts. Biochem Pharmacol. 1985 Jul 15; 34(14):2557-60.
    View in: PubMed
  486. Griffin JD, Spriggs D, Wisch JS, Kufe DW. Treatment of preleukemic syndromes with continuous intravenous infusion of low-dose cytosine arabinoside. J Clin Oncol. 1985 Jul; 3(7):982-91.
    View in: PubMed
  487. Sariban E, Mitchell T, Kufe D. Expression of the c-fms proto-oncogene during human monocytic differentiation. Nature. 1985 Jul 4-10; 316(6023):64-6.
    View in: PubMed
  488. Kufe DW, Spriggs DR. Biochemical and cellular pharmacology of cytosine arabinoside. Semin Oncol. 1985 Jun; 12(2 Suppl 3):34-48.
    View in: PubMed
  489. Watanabe T, Mitchell T, Sariban E, Sabbath K, Griffin J, Kufe D. Effects of 1-beta-D-arabinofuranosylcytosine and phorbol ester on differentiation of human K562 erythroleukemia cells. Mol Pharmacol. 1985 Jun; 27(6):683-8.
    View in: PubMed
  490. Kufe DW, Griffin JD, Spriggs DR. Cellular and clinical pharmacology of low-dose ara-C. Semin Oncol. 1985 Jun; 12(2 Suppl 3):200-7.
    View in: PubMed
  491. Spriggs D, Griffin J, Wisch J, Kufe D. Clinical pharmacology of low-dose cytosine arabinoside. Blood. 1985 May; 65(5):1087-9.
    View in: PubMed
  492. Hayes DF, Sekine H, Ohno T, Abe M, Keefe K, Kufe DW. Use of a murine monoclonal antibody for detection of circulating plasma DF3 antigen levels in breast cancer patients. J Clin Invest. 1985 May; 75(5):1671-8.
    View in: PubMed
  493. Watanabe T, Shafman T, Kufe DW. Requirement of spermidine for induction of both heme synthesis and globin transcription in murine erythroleukemia cells. J Cell Physiol. 1985 Mar; 122(3):435-40.
    View in: PubMed
  494. Watanabe T, Sariban E, Mitchell T, Kufe D. Human c-myc and N-ras expression during induction of HL-60 cellular differentiation. Biochem Biophys Res Commun. 1985 Feb 15; 126(3):999-1005.
    View in: PubMed
  495. Lundy J, Thor A, Maenza R, Schlom J, Forouhar F, Testa M, Kufe D. Monoclonal antibody DF3 correlates with tumor differentiation and hormone receptor status in breast cancer patients. Breast Cancer Res Treat. 1985; 5(3):269-76.
    View in: PubMed
  496. Schlom J, Colcher D, Hand PH, Greiner J, Wunderlich D, Weeks M, Fisher PB, Noguchi P, Pestka S, Kufe D. Monoclonal antibodies reactive with breast tumor-associated antigens. Adv Cancer Res. 1985; 43:143-73.
    View in: PubMed
  497. Fram RJ, Kufe DW. Inhibition of DNA excision repair and the repair of X-ray-induced DNA damage by cytosine arabinoside and hydroxyurea. Pharmacol Ther. 1985; 31(3):165-76.
    View in: PubMed
  498. Zalutsky MR, Colcher D, Kaplan WD, Kufe DW. Radioiodinated B6.2 monoclonal antibody: further characterization of a potential radiopharmaceutical for the identification of breast tumors. Int J Nucl Med Biol. 1985; 12(3):227-33.
    View in: PubMed
  499. Schlom J, Greiner J, Hand PH, Colcher D, Inghirami G, Weeks M, Pestka S, Fisher PB, Noguchi P, Kufe D. Monoclonal antibodies to breast cancer-associated antigens as potential reagents in the management of breast cancer. Cancer. 1984 Dec 1; 54(11 Suppl):2777-94.
    View in: PubMed
  500. Shafman TD, Sherman ML, Kufe DW. Effect of 5'-methylthioadenosine on induction of murine erythroleukemia cell differentiation. Biochem Biophys Res Commun. 1984 Oct 15; 124(1):172-7.
    View in: PubMed
  501. Kufe DW, Griffin J, Mitchell T, Shafman T. Polyamine requirements for induction of HL-60 promyelocyte differentiation by leukocyte-conditioned medium and phorbol ester. Cancer Res. 1984 Oct; 44(10):4281-4.
    View in: PubMed
  502. Abe M, Kufe DW. Sodium butyrate induction of milk-related antigens in human MCF-7 breast carcinoma cells. Cancer Res. 1984 Oct; 44(10):4574-7.
    View in: PubMed
  503. Luisi-DeLuca C, Mitchell T, Spriggs D, Kufe DW. Induction of terminal differentiation in human K562 erythroleukemia cells by arabinofuranosylcytosine. J Clin Invest. 1984 Sep; 74(3):821-7.
    View in: PubMed
  504. Sugiura M, Fram R, Munroe D, Kufe D. DNA strand scission and ADP-ribosyltransferase activity during murine erythroleukemia cell differentiation. Dev Biol. 1984 Aug; 104(2):484-8.
    View in: PubMed
  505. Kufe DW, Herrick D, Gunner L. Uracil enhancement of 5-fluorodexoyuridine incorporation into human breast carcinoma deoxyribonucleic acid. Biochem Pharmacol. 1984 Jul 15; 33(14):2329-31.
    View in: PubMed
  506. Kufe D, Spriggs D, Egan EM, Munroe D. Relationships among Ara-CTP pools, formation of (Ara-C)DNA, and cytotoxicity of human leukemic cells. Blood. 1984 Jul; 64(1):54-8.
    View in: PubMed
  507. Kufe DW, Munroe D, Herrick D, Egan E, Spriggs D. Effects of 1-beta-D-arabinofuranosylcytosine incorporation on eukaryotic DNA template function. Mol Pharmacol. 1984 Jul; 26(1):128-34.
    View in: PubMed
  508. Herrick D, Kufe DW. Lethality associated with incorporation of 5-fluorouracil into preribosomal RNA. Mol Pharmacol. 1984 Jul; 26(1):135-40.
    View in: PubMed
  509. Szpak CA, Johnston WW, Lottich SC, Kufe D, Thor A, Schlom J. Patterns of reactivity of four novel monoclonal antibodies (B72.3, DF3, B1.1 and B6.2) with cells in human malignant and benign effusions. Acta Cytol. 1984 Jul-Aug; 28(4):356-67.
    View in: PubMed
  510. Sugiura M, Shafman T, Mitchell T, Griffin J, Kufe D. Involvement of spermidine in proliferation and differentiation of human promyelocytic leukemia cells. Blood. 1984 May; 63(5):1153-8.
    View in: PubMed
  511. Sugiura M, Shafman T, Kufe D. Effects of polyamine depletion on proliferation and differentiation of murine erythroleukemia cells. Cancer Res. 1984 Apr; 44(4):1440-4.
    View in: PubMed
  512. Kufe DW, Weichselbaum R, Egan EM, Dahlberg W, Fram RJ. Lethal effects of 1-beta-D-arabinofuranosylcytosine incorporation into deoxyribonucleic acid during ultraviolet repair. Mol Pharmacol. 1984 Mar; 25(2):322-6.
    View in: PubMed
  513. Kufe D, Herrick D, Crumpacker C, Schnipper L. Incorporation of 1-beta-D-arabinofuranosylcytosine into DNA from herpes simplex virus resistant to 9-beta-D-arabinofuranosyladenine. Cancer Res. 1984 Jan; 44(1):69-73.
    View in: PubMed
  514. Peters WP, Weiss G, Kufe DW. Phase-I trial of combination therapy with continuous-infusion MMPR and continuous-infusion 5-FU. Cancer Chemother Pharmacol. 1984; 13(2):136-8.
    View in: PubMed
  515. Fram RJ, Kufe DW. The effect of inhibitors of DNA synthesis on DNA repair. Nucleic Acids Symp Ser. 1984; (13):95-107.
    View in: PubMed
  516. Abe M, Kufe DW. Effect of sodium butyrate on human breast carcinoma (MCF-7) cellular proliferation, morphology, and CEA production. Breast Cancer Res Treat. 1984; 4(4):269-74.
    View in: PubMed
  517. Kufe D, Inghirami G, Abe M, Hayes D, Justi-Wheeler H, Schlom J. Differential reactivity of a novel monoclonal antibody (DF3) with human malignant versus benign breast tumors. Hybridoma. 1984; 3(3):223-32.
    View in: PubMed
  518. Munroe D, Sugiura M, Griffin J, Kufe D. Effect of ara-A on differentiation and proliferation of HL-60 cells. Leuk Res. 1984; 8(3):355-61.
    View in: PubMed
  519. Wisch JS, Griffin JD, Kufe DW. Response of preleukemic syndromes to continuous infusion of low-dose cytarabine. N Engl J Med. 1983 Dec 29; 309(26):1599-602.
    View in: PubMed
  520. Egan EM, Justi-Wheeler H, Kufe DW. Alkali lability of deoxyribonucleic acid that contains adenine arabinoside. Biochem Pharmacol. 1983 Dec 15; 32(24):3849-52.
    View in: PubMed
  521. Minden M, Major P, Griffin J, Wu A, Kufe D. Generation time of leukaemic blast progenitor cells. Cell Tissue Kinet. 1983 Nov; 16(6):577-82.
    View in: PubMed
  522. Kufe DW, Major PP, Munroe D, Egan M, Herrick D. Relationship between incorporation of 9-beta-D-arabinofuranosyladenine in L 1210 DNA and cytotoxicity. Cancer Res. 1983 May; 43(5):2000-4.
    View in: PubMed
  523. Kufe DW, Scott P, Fram R, Major P. Biologic effect of 5-fluoro-2'-deoxyuridine incorporation in L1210 deoxyribonucleic acid. Biochem Pharmacol. 1983 Apr 15; 32(8):1337-40.
    View in: PubMed
  524. Colcher D, Zalutsky M, Kaplan W, Kufe D, Austin F, Schlom J. Radiolocalization of human mammary tumors in athymic mice by a monoclonal antibody. Cancer Res. 1983 Feb; 43(2):736-42.
    View in: PubMed
  525. Kufe DW, Nadler L, Sargent L, Shapiro H, Hand P, Austin F, Colcher D, Schlom J. Biological behavior of human breast carcinoma-associated antigens expressed during cellular proliferation. Cancer Res. 1983 Feb; 43(2):851-7.
    View in: PubMed
  526. Colcher D, Hand PH, Wunderlich D, Nuti M, Teramoto YA, Kufe D, Schlom J. Monoclonal antibodies to human mammary carcinoma associated antigens and their potential uses for diagnosis, prognosis, and therapy. Lab Res Methods Biol Med. 1983; 8:215-58.
    View in: PubMed
  527. Fram RJ, Egan EM, Kufe DW. Accumulation of leukemic cell DNA strand breaks with adriamycin and cytosine arabinoside. Leuk Res. 1983; 7(2):243-9.
    View in: PubMed
  528. Major PP, Agarwal RP, Kufe DW. Clinical pharmacology of arabinofuranosyladenine in combination with deoxycoformycin. Cancer Chemother Pharmacol. 1983; 10(2):125-8.
    View in: PubMed
  529. Fram R, Major P, Egan E, Beardsley P, Rosenthal D, Kufe D. A phase I-II study of combination therapy with thymidine and cytosine arabinoside. Cancer Chemother Pharmacol. 1983; 11(1):43-7.
    View in: PubMed
  530. Rosowsky A, Abelson HT, Beardsley GP, Ensminger WD, Kufe DW, Steele G, Modest EJ. Pharmacologic studies on the dibutyl and gamma-monobutyl esters of methotrexate in the rhesus monkey. Cancer Chemother Pharmacol. 1982 Dec; 10(1):55-61.
    View in: PubMed
  531. Herrick DJ, Major PP, Kufe DW. Effect of methotrexate on incorporation and excision of 5-fluorouracil residues in human breast carcinoma DNA. Cancer Res. 1982 Dec; 42(12):5015-7.
    View in: PubMed
  532. Griffin J, Munroe D, Major P, Kufe D. Induction of differentiation of human myeloid leukemia cells by inhibitors of DNA synthesis. Exp Hematol. 1982 Oct; 10(9):774-81.
    View in: PubMed
  533. Fram RJ, Kufe DW. DNA strand breaks caused by inhibitors of DNA synthesis: 1-beta-D-arabinofuranosylcytosine and aphidicolin. Cancer Res. 1982 Oct; 42(10):4050-3.
    View in: PubMed
  534. Major PP, Egan EM, Herrick DJ, Kufe DW. Effect of ARA-C incorporation on deoxyribonucleic acid synthesis in cells. Biochem Pharmacol. 1982 Sep 15; 31(18):2937-40.
    View in: PubMed
  535. Agarwal RP, Major PP, Kufe DW. Simple and rapid high-performance liquid chromatographic method for analysis of nucleosides in biological fluids. J Chromatogr. 1982 Sep 10; 231(2):418-24.
    View in: PubMed
  536. Weiss GR, McGovren JP, Schade D, Kufe DW. Phase I and pharmacological study of acivicin by 24-hour continuous infusion. Cancer Res. 1982 Sep; 42(9):3892-5.
    View in: PubMed
  537. Major PP, Egan E, Herrick D, Kufe DW. 5-Fluorouracil incorporation in DNA of human breast carcinoma cells. Cancer Res. 1982 Aug; 42(8):3005-9.
    View in: PubMed
  538. Major PP, Egan EM, Herrick D, Kufe DW. Instability of (ara-C) DNA under alkaline conditions. Biochem Pharmacol. 1982 Mar 1; 31(5):861-6.
    View in: PubMed
  539. Weiss GR, Ervin TJ, Meshad MW, Kufe DW. Phase II trial of combination therapy with continuous-infusion PALA and bolus-injection 5-FU. Cancer Treat Rep. 1982 Feb; 66(2):299-303.
    View in: PubMed
  540. Kufe DW, Major PP. Studies on the mechanism of action of cytosine arabinoside. Med Pediatr Oncol. 1982; 10 Suppl 1:49-67.
    View in: PubMed
  541. Major PP, Egan EM, Sargent L, Kufe DW. Modulation of 5-FU metabolism in human MCF-7 breast carcinoma cells. Cancer Chemother Pharmacol. 1982; 8(1):87-91.
    View in: PubMed
  542. Weiss GR, Ervin TJ, Meshad MW, Schade D, Branfman AR, Bruni RJ, Chadwick M, Kufe DW. A phase I trial of combination therapy with continuous-infusion PALA and continuous-infusion 5-FU. Cancer Chemother Pharmacol. 1982; 8(3):301-4.
    View in: PubMed
  543. Kufe DW, Major PP. 5-Fluorouracil incorporation into human breast carcinoma RNA correlates with cytotoxicity. J Biol Chem. 1981 Oct 10; 256(19):9802-5.
    View in: PubMed
  544. Kufe DW, Wick MM, Moschella S, Major P. Effect of high-dose thymidine infusions in patients with mycosis fungoides. Cancer. 1981 Oct 1; 48(7):1513-6.
    View in: PubMed
  545. Kufe DW, Major PP, Egan EM, Loh E. 5-Fluoro-2'-deoxyuridine incorporation in L1210 DNA. J Biol Chem. 1981 Sep 10; 256(17):8885-8.
    View in: PubMed
  546. Loh E, Kufe DW. Synergistic effects with inhibitors of de novo pyrimidine synthesis, acivicin, and N-(phosphonacetyl)-L-aspartic acid. Cancer Res. 1981 Sep; 41(9 Pt 1):3419-23.
    View in: PubMed
  547. Egan EM, Sargent L, Rosowsky A, Kufe DW. Rescue of thymidine cytotoxicity in L1210 ascites by elevated endogenous levels of deoxycytidine. Cancer Treat Rep. 1981 Sep-Oct; 65(9-10):853-60.
    View in: PubMed
  548. Major PP, Sargent L, Egan EM, Kufe DW. Correlation of thymidine-enhanced incorporation of ara-C in deoxyribonucleic acid with increased cell kill. Biochem Pharmacol. 1981 Aug 15; 30(16):2221-4.
    View in: PubMed
  549. Major PP, Agarwal RP, Kufe DW. Clinical pharmacology of deoxycoformycin. Blood. 1981 Jul; 58(1):91-6.
    View in: PubMed
  550. Major PP, Egan EM, Beardsley GP, Minden MD, Kufe DW. Lethality of human myeloblasts correlates with the incorporation of arabinofuranosylcytosine into DNA. Proc Natl Acad Sci U S A. 1981 May; 78(5):3235-9.
    View in: PubMed
  551. Meshad MW, Ervin TJ, Kufe D, Johnson RK, Blum RH, Frei E. Phase I trial of combination therapy with PALA and 5-FU. Cancer Treat Rep. 1981 Mar-Apr; 65(3-4):331-4.
    View in: PubMed
  552. Kufe DW, Egan EM. Enhancement of 5-fluorouracil incorporation into human lymphoblast ribonucleic acid. Biochem Pharmacol. 1981 Jan 15; 30(2):129-33.
    View in: PubMed
  553. Rosowsky A, Wright JE, Steele G, Kufe DW. Thymidine 5'-O-pivaloate: evidence for prodrug action in the rat and rhesus monkey. Cancer Treat Rep. 1981 Jan-Feb; 65(1-2):93-9.
    View in: PubMed
  554. Major PP, Griffin JD, Minden M, Kufe DW. A blast subclone of the HL-60 human promyelocytic cell line. Leuk Res. 1981; 5(4-5):429-30.
    View in: PubMed
  555. Abelson HT, Kufe DW, Skarin AT, Major P, Ensminger W, Beardsley GP, Canellos GP. Treatment of central nervous system tumors with methotrexate. Cancer Treat Rep. 1981; 65 Suppl 1:137-40.
    View in: PubMed
  556. Major PP, Agarwal RP, Kufe DW. Deoxycoformycin: neurological toxicity. Cancer Chemother Pharmacol. 1981; 5(3):193-6.
    View in: PubMed
  557. Kufe DW, Major PP, Egan EM, Beardsley GP. Correlation of cytotoxicity with incorporation of ara-C into DNA. J Biol Chem. 1980 Oct 10; 255(19):8997-900.
    View in: PubMed
  558. Kufe DW, Wick MM, Abelson HT. Natural resistance to methotrexate in human melanomas. J Invest Dermatol. 1980 Oct; 75(4):357-9.
    View in: PubMed
  559. Ervin TJ, Blum RH, Meshad MW, Kufe DW, Johnson RK, Canellos GP. Phase I trial of N-(Phosphonacetyl)-L-aspartic acid (PALA). Cancer Treat Rep. 1980 Oct-Nov; 64(10-11):1067-71.
    View in: PubMed
  560. Nadler LM, Stashenko P, Hardy R, Kaplan WD, Button LN, Kufe DW, Antman KH, Schlossman SF. Serotherapy of a patient with a monoclonal antibody directed against a human lymphoma-associated antigen. Cancer Res. 1980 Sep; 40(9):3147-54.
    View in: PubMed
  561. Kufe DW, Beardsley P, Karp D, Parker L, Rosowsky A, Canellos G, Frei E. High-dose thymidine infusions in patients with leukemia and lymphoma. Blood. 1980 Apr; 55(4):580-9.
    View in: PubMed
  562. Kufe DW, Egan EM, Rosowsky A, Ensminger W, Frei E. Thymidine arrest and synchrony of cellular growth in vivo. Cancer Treat Rep. 1980; 64(12):1307-17.
    View in: PubMed
  563. Campbell WF, Kufe DW, Peters WP, Spiegelman S, Frankel JW. Contrasting characteristics of Marek's disease herpesvirus isolated from chickens with and without avian leukosis virus infection. Intervirology. 1978; 10(1):11-23.
    View in: PubMed
  564. Teramoto YA, Kufe D, Schlom J. Type-specific antigenic determinants on the major external glycoprotein of high- and low-oncogenic murine mammary tumor viruses. J Virol. 1977 Nov; 24(2):525-33.
    View in: PubMed
  565. Teramoto YA, Kufe D, Schlom J. Multiple antigenic determinants on the major surface glycoprotein of murine mammary tumor viruses. Proc Natl Acad Sci U S A. 1977 Aug; 74(8):3564-8.
    View in: PubMed
  566. Chan E, Peters WP, Sweet RW, Ohno T, Kufe DW, Spiegelman S, Gallo RC, Gallagher RE. Characterisation of a virus (HL23V) isolated from cultured acute myelogenous leukaemic cells. Nature. 1976 Mar 18; 260(5548):266-8.
    View in: PubMed
  567. Spiegelman S, Axel R, Baxt W, Kufe D, Schlom J. The molecular genetics of human cancer and its etiologic implications. Genetics. 1975 Jun; 79 Suppl:317-38.
    View in: PubMed
  568. Spiegelman S, Baxt W, Kufe D, Peters WP, Schlom J. Sequences related to the RNA tumor viruses in the RNA and DNA of human leukemias and lymphomas. Bibl Haematol. 1975; (40):3-25.
    View in: PubMed
  569. Spiegelman S, Axel R, Baxt W, Kufe D, Schlom J. Human cancer and animal viral oncology. Cancer. 1974 Oct; 34(4 Suppl):suppl:1406-20.
    View in: PubMed
  570. Kufe D, Peters WP, Spiegelman S. RNA tumor viruses and human lymphomas. Hamatol Bluttransfus. 1974; 14:164-74.
    View in: PubMed
  571. Kufe DW, Peters WP, Spiegelman S. Unique nuclear DNA sequences in the involved tissues of Hodgkin's and Burkitt's lymphomas. Proc Natl Acad Sci U S A. 1973 Dec; 70(12):3810-4.
    View in: PubMed
  572. Peters WP, Kufe D, Schlom J, Frankel JW, Prickett CO, Groupé V, Spiegelman S. Biological and biochemical evidence for an interaction between Marek's disease herpesvirus and avian leukosis virus in vivo. Proc Natl Acad Sci U S A. 1973 Nov; 70(11):3175-8.
    View in: PubMed
  573. Schlom J, Michalides R, Kufe D, Hehlmann R, Spiegelman S, Bentvelzen P, Hageman P. A comparative study of the biologic and molecular basis of murine mammary carcinoma: a model for human breast cancer. J Natl Cancer Inst. 1973 Aug; 51(2):541-51.
    View in: PubMed
  574. Hehlmann R, Baxt W, Kufe D, Spiegelman S. Molecular evidence for a viral etiology of human leukemias, lymphomas, and sarcomas. Am J Clin Pathol. 1973 Jul; 60(1):65-79.
    View in: PubMed
  575. Spiegelman S, Kufe D, Hehlmann R, Peters WP. Evidence for RNA tumor viruses in human lymphomas including Burkitt's disease. Cancer Res. 1973 Jun; 33(6):1515-26.
    View in: PubMed
  576. Kufe D, Magrath IT, Ziegler JL, Spiegelman S. Burkitt's tumors contain particles encapsulating RNA-instructed DNA polymerase and high molecular weight virus-related RNA. Proc Natl Acad Sci U S A. 1973 Mar; 70(3):737-41.
    View in: PubMed
  577. Kufe D, Hehlmann R, Spiegelman S. RNA related to that of a murine leukemia virus in Burkitt's tumors and nasopharyngeal carcinomas. Proc Natl Acad Sci U S A. 1973 Jan; 70(1):5-9.
    View in: PubMed
  578. Hehlmann R, Kufe D, Baxt W, Spiegelman S. [70S RNA containing particles in human leukemias]. Verh Dtsch Ges Inn Med. 1973; 79:402-5.
    View in: PubMed
  579. Spiegelman S, Axel R, Baxt W, Gulati SC, Hehlmann R, Kufe D, Schlom J. The relevance of RNA tumor viruses to human cancer. Johns Hopkins Med J Suppl. 1973; 2:282-312.
    View in: PubMed
  580. Hehlmann R, Kufe D, Spiegelman S. Viral-related RNA in Hodgkins' disease and other human lymphomas. Proc Natl Acad Sci U S A. 1972 Jul; 69(7):1727-31.
    View in: PubMed
  581. Hehlmann R, Kufe D, Spiegelman S. RNA in human leukemic cells related to the RNA of a mouse leukemia virus (leukocytes-RNA-DNA hybridization-rauscher virus-polysomal RNA). Proc Natl Acad Sci U S A. 1972 Feb; 69(2):435-9.
    View in: PubMed
  582. Kufe D, Hehlmann R, Spiegelman S. Human sarcomas contain RNA related to the RNA of a mouse leukemia virus. Science. 1972 Jan 14; 175(4018):182-5.
    View in: PubMed
  583. Spiegelman S, Axel R, Baxt W, Gulati SC, Hehlmann R, Kufe D, Schlom J. Proceedings: Genetics and the cancer cell: molecular evidence for a viral etiology of human cancer. Proc Natl Cancer Conf. 1972; 7:21-40.
    View in: PubMed
  584. Kufe DW, Howland JL. Oxidative phosphorylation in Corynebacterium diphtheriae. Biochim Biophys Acta. 1968 Jan 15; 153(1):291-3.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Kufe's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
Co-Authors
_
Similar People
_
Same Department
Physical Neighbors
_