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Pamela A. Silver, Ph.D.

TitleElliott T. and Onie H. Adams Professor of Biochemistry and Systems Biology
InstitutionHarvard Medical School
DepartmentSystems Biology
AddressHarvard Medical School
Systems Biology Alpert 536
200 Longwood Ave
Boston MA 02115
Phone617/432-6401
Fax617/432-5012

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lienert F, Lohmueller JJ, Garg A, Silver PA. Synthetic biology in mammalian cells: next generation research tools and therapeutics. Nat Rev Mol Cell Biol. 2014 Feb; 15(2):95-107.
    View in: PubMed
  2. Polka JK, Silver PA. Building synthetic cellular organization. Mol Biol Cell. 2013 Dec; 24(23):3585-7.
    View in: PubMed
  3. Wintermute EH, Lieberman TD, Silver PA. An objective function exploiting suboptimal solutions in metabolic networks. BMC Syst Biol. 2013; 7:98.
    View in: PubMed
  4. Torella JP, Boehm CR, Lienert F, Chen JH, Way JC, Silver PA. Rapid construction of insulated genetic circuits via synthetic sequence-guided isothermal assembly. Nucleic Acids Res. 2014 Jan 7; 42(1):681-9.
    View in: PubMed
  5. Inniss MC, Silver PA. Building synthetic memory. Curr Biol. 2013 Sep 9; 23(17):R812-6.
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  6. Voges MJ, Silver PA, Way JC, Mattozzi MD. Targeting a heterologous protein to multiple plant organelles via rationally designed 5' mRNA tags. J Biol Eng. 2013; 7(1):20.
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  7. Chen AH, Robinson-Mosher A, Savage DF, Silver PA, Polka JK. The bacterial carbon-fixing organelle is formed by shell envelopment of preassembled cargo. PLoS One. 2013; 8(9):e76127.
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  8. Lienert F, Torella JP, Chen JH, Norsworthy M, Richardson RR, Silver PA. Two- and three-input TALE-based AND logic computation in embryonic stem cells. Nucleic Acids Res. 2013 Nov 1; 41(21):9967-75.
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  9. Myhrvold C, Dai M, Silver PA, Yin P. Isothermal Self-Assembly of Complex DNA Structures under Diverse and Biocompatible Conditions. Nano Lett. 2013 Sep 11; 13(9):4242-8.
    View in: PubMed
  10. Torella JP, Ford TJ, Kim SN, Chen AM, Way JC, Silver PA. Tailored fatty acid synthesis via dynamic control of fatty acid elongation. Proc Natl Acad Sci U S A. 2013 Jul 9; 110(28):11290-5.
    View in: PubMed
  11. Robinson-Mosher A, Shinar T, Silver PA, Way J. Dynamics simulations for engineering macromolecular interactions. Chaos. 2013 Jun; 23(2):025110.
    View in: PubMed
  12. Selgrade DF, Lohmueller JJ, Lienert F, Silver PA. Protein scaffold-activated protein trans-splicing in Mammalian cells. J Am Chem Soc. 2013 May 22; 135(20):7713-9.
    View in: PubMed
  13. Wang Q, Moore MJ, Adelmant G, Marto JA, Silver PA. PQBP1, a factor linked to intellectual disability, affects alternative splicing associated with neurite outgrowth. Genes Dev. 2013 Mar 15; 27(6):615-26.
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  14. Mattozzi MD, Ziesack M, Voges MJ, Silver PA, Way JC. Expression of the sub-pathways of the Chloroflexus aurantiacus 3-hydroxypropionate carbon fixation bicycle in E. coli: Toward horizontal transfer of autotrophic growth. Metab Eng. 2013 Mar; 16:130-9.
    View in: PubMed
  15. Chen AH, Afonso B, Silver PA, Savage DF. Spatial and Temporal Organization of Chromosome Duplication and Segregation in the Cyanobacterium Synechococcus elongatus PCC 7942. PLoS One. 2012; 7(10):e47837.
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  16. Delebecque CJ, Silver PA, Lindner AB. Designing and using RNA scaffolds to assemble proteins in vivo. Nat Protoc. 2012 Oct; 7(10):1797-807.
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  17. Chen AH, Silver PA. Designing biological compartmentalization. Trends Cell Biol. 2012 Dec; 22(12):662-70.
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  18. Chen AJ, Paik JH, Zhang H, Shukla SA, Mortensen R, Hu J, Ying H, Hu B, Hurt J, Farny N, Dong C, Xiao Y, Wang YA, Silver PA, Chin L, Vasudevan S, Depinho RA. STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA. Genes Dev. 2012 Jul 1; 26(13):1459-72.
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  19. Burrill DR, Inniss MC, Boyle PM, Silver PA. Synthetic memory circuits for tracking human cell fate. Genes Dev. 2012 Jul 1; 26(13):1486-97.
    View in: PubMed
  20. Boyle PM, Burrill DR, Inniss MC, Agapakis CM, Deardon A, Dewerd JG, Gedeon MA, Quinn JY, Paull ML, Raman AM, Theilmann MR, Wang L, Winn JC, Medvedik O, Schellenberg K, Haynes KA, Viel A, Brenner TJ, Church GM, Shah JV, Silver PA. A BioBrick compatible strategy for genetic modification of plants. J Biol Eng. 2012; 6(1):8.
    View in: PubMed
  21. Ducat DC, Silver PA. Improving carbon fixation pathways. Curr Opin Chem Biol. 2012 Aug; 16(3-4):337-44.
    View in: PubMed
  22. Agapakis CM, Boyle PM, Silver PA. Natural strategies for the spatial optimization of metabolism in synthetic biology. Nat Chem Biol. 2012 Jun; 8(6):527-35.
    View in: PubMed
  23. Garg A, Lohmueller JJ, Silver PA, Armel TZ. Engineering synthetic TAL effectors with orthogonal target sites. Nucleic Acids Res. 2012 Aug; 40(15):7584-95.
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  24. Adelmant G, Calkins AS, Garg BK, Card JD, Askenazi M, Miron A, Sobhian B, Zhang Y, Nakatani Y, Silver PA, Iglehart JD, Marto JA, Lazaro JB. DNA ends alter the molecular composition and localization of Ku multicomponent complexes. Mol Cell Proteomics. 2012 Aug; 11(8):411-21.
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  25. Haynes KA, Ceroni F, Flicker D, Younger A, Silver PA. A sensitive switch for visualizing natural gene silencing in single cells. ACS Synth Biol. 2012 Mar 16; 1(3):99-106.
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  26. Nishida K, Silver PA. Induction of biogenic magnetization and redox control by a component of the target of rapamycin complex 1 signaling pathway. PLoS Biol. 2012; 10(2):e1001269.
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  27. Lohmueller JJ, Armel TZ, Silver PA. A tunable zinc finger-based framework for Boolean logic computation in mammalian cells. Nucleic Acids Res. 2012 Jun; 40(11):5180-7.
    View in: PubMed
  28. Silver P. Pamela Silver: synthesizing a new biology. Interview by Caitlin Sedwick. J Cell Biol. 2012 Feb 6; 196(3):302-3.
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  29. Ducat DC, Avelar-Rivas JA, Way JC, Silver PA. Rerouting carbon flux to enhance photosynthetic productivity. Appl Environ Microbiol. 2012 Apr; 78(8):2660-8.
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  30. Bonacci W, Teng PK, Afonso B, Niederholtmeyer H, Grob P, Silver PA, Savage DF. Modularity of a carbon-fixing protein organelle. Proc Natl Acad Sci U S A. 2012 Jan 10; 109(2):478-83.
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  31. Burrill DR, Boyle PM, Silver PA. A new approach to an old problem: synthetic biology tools for human disease and metabolism. Cold Spring Harb Symp Quant Biol. 2011; 76:145-54.
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  32. Boyle PM, Silver PA. Parts plus pipes: synthetic biology approaches to metabolic engineering. Metab Eng. 2012 May; 14(3):223-32.
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  33. Burrill DR, Silver PA. Recording cellular experiences of DNA damage. Cell Cycle. 2011 Aug 1; 10(15):2410-1.
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  34. Waks Z, Klein AM, Silver PA. Cell-to-cell variability of alternative RNA splicing. Mol Syst Biol. 2011; 7:506.
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  35. Delebecque CJ, Lindner AB, Silver PA, Aldaye FA. Organization of intracellular reactions with rationally designed RNA assemblies. Science. 2011 Jul 22; 333(6041):470-4.
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  36. Haynes KA, Silver PA. Synthetic reversal of epigenetic silencing. J Biol Chem. 2011 Aug 5; 286(31):27176-82.
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  37. Shih JD, Waks Z, Kedersha N, Silver PA. Visualization of single mRNAs reveals temporal association of proteins with microRNA-regulated mRNA. Nucleic Acids Res. 2011 Sep 1; 39(17):7740-9.
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  38. Barstow B, Agapakis CM, Boyle PM, Grandl G, Silver PA, Wintermute EH. A synthetic system links FeFe-hydrogenases to essential E. coli sulfur metabolism. J Biol Eng. 2011; 5:7.
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  39. Agapakis CM, Niederholtmeyer H, Noche RR, Lieberman TD, Megason SG, Way JC, Silver PA. Towards a synthetic chloroplast. PLoS One. 2011; 6(4):e18877.
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  40. Senapedis WT, Kennedy CJ, Boyle PM, Silver PA. Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain. Mol Biol Cell. 2011 May 15; 22(10):1791-805.
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  41. Waks Z, Silver PA. Nuclear origins of cell-to-cell variability. Cold Spring Harb Symp Quant Biol. 2010; 75:87-94.
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  42. Smolke CD, Silver PA. Informing biological design by integration of systems and synthetic biology. Cell. 2011 Mar 18; 144(6):855-9.
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  43. Burrill DR, Silver PA. Synthetic circuit identifies subpopulations with sustained memory of DNA damage. Genes Dev. 2011 Mar 1; 25(5):434-9.
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  44. Ducat DC, Sachdeva G, Silver PA. Rewiring hydrogenase-dependent redox circuits in cyanobacteria. Proc Natl Acad Sci U S A. 2011 Mar 8; 108(10):3941-6.
    View in: PubMed
  45. Ducat DC, Way JC, Silver PA. Engineering cyanobacteria to generate high-value products. Trends Biotechnol. 2011 Feb; 29(2):95-103.
    View in: PubMed
  46. Wintermute EH, Silver PA. Dynamics in the mixed microbial concourse. Genes Dev. 2010 Dec 1; 24(23):2603-14.
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  47. Wang Q, Silver PA. Genome-wide RNAi screen discovers functional coupling of alternative splicing and cell cycle control to apoptosis regulation. Cell Cycle. 2010 Nov 15; 9(22):4419-21.
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  48. Agapakis CM, Silver PA. Modular electron transfer circuits for synthetic biology: insulation of an engineered biohydrogen pathway. Bioeng Bugs. 2010 Nov-Dec; 1(6):413-8.
    View in: PubMed
  49. Aldaye FA, Senapedis WT, Silver PA, Way JC. A structurally tunable DNA-based extracellular matrix. J Am Chem Soc. 2010 Oct 27; 132(42):14727-9.
    View in: PubMed
  50. Wintermute EH, Silver PA. Emergent cooperation in microbial metabolism. Mol Syst Biol. 2010 Sep 7; 6:407.
    View in: PubMed
  51. Moore MJ, Wang Q, Kennedy CJ, Silver PA. An alternative splicing network links cell-cycle control to apoptosis. Cell. 2010 Aug 20; 142(4):625-36.
    View in: PubMed
  52. Silver PA. Knowing when to change: reprogramming (my) life. Nat Cell Biol. 2010 Aug; 12(8):730.
    View in: PubMed
  53. Niederholtmeyer H, Wolfstädter BT, Savage DF, Silver PA, Way JC. Engineering cyanobacteria to synthesize and export hydrophilic products. Appl Environ Microbiol. 2010 Jun; 76(11):3462-6.
    View in: PubMed
  54. Savage DF, Afonso B, Chen AH, Silver PA. Spatially ordered dynamics of the bacterial carbon fixation machinery. Science. 2010 Mar 5; 327(5970):1258-61.
    View in: PubMed
  55. Agapakis CM, Ducat DC, Boyle PM, Wintermute EH, Way JC, Silver PA. Insulation of a synthetic hydrogen metabolism circuit in bacteria. J Biol Eng. 2010; 4:3.
    View in: PubMed
  56. Afonso B, Silver PA, Ajo-Franklin CM. A synthetic circuit for selectively arresting daughter cells to create aging populations. Nucleic Acids Res. 2010 May; 38(8):2727-35.
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  57. Taylor ND, Way JC, Silver PA, Cironi P. Anti-glycophorin single-chain Fv fusion to low-affinity mutant erythropoietin improves red blood cell-lineage specificity. Protein Eng Des Sel. 2010 Apr; 23(4):251-60.
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  58. Burrill DR, Silver PA. Making cellular memories. Cell. 2010 Jan 8; 140(1):13-8.
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  59. Haynes KA, Silver PA. Eukaryotic systems broaden the scope of synthetic biology. J Cell Biol. 2009 Nov 30; 187(5):589-96.
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  60. Farny NG, Kedersha NL, Silver PA. Metazoan stress granule assembly is mediated by P-eIF2alpha-dependent and -independent mechanisms. RNA. 2009 Oct; 15(10):1814-21.
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  61. Kennedy CJ, Boyle PM, Waks Z, Silver PA. Systems-level engineering of nonfermentative metabolism in yeast. Genetics. 2009 Sep; 183(1):385-97.
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  62. Agapakis CM, Silver PA. Synthetic biology: exploring and exploiting genetic modularity through the design of novel biological networks. Mol Biosyst. 2009 Jul; 5(7):704-13.
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  63. Hurt JA, Obar RA, Zhai B, Farny NG, Gygi SP, Silver PA. A conserved CCCH-type zinc finger protein regulates mRNA nuclear adenylation and export. J Cell Biol. 2009 Apr 20; 185(2):265-77.
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  64. Boyle PM, Silver PA. Harnessing nature's toolbox: regulatory elements for synthetic biology. J R Soc Interface. 2009 Aug 6; 6 Suppl 4:S535-46.
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  65. Waks Z, Silver PA. Engineering a synthetic dual-organism system for hydrogen production. Appl Environ Microbiol. 2009 Apr; 75(7):1867-75.
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  66. Lee SI, Dudley AM, Drubin D, Silver PA, Krogan NJ, Pe'er D, Koller D. Learning a prior on regulatory potential from eQTL data. PLoS Genet. 2009 Jan; 5(1):e1000358.
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  67. Hurt JA, Silver PA. mRNA nuclear export and human disease. Dis Model Mech. 2008 Sep-Oct; 1(2-3):103-8.
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  68. Swinburne IA, Miguez DG, Landgraf D, Silver PA. Intron length increases oscillatory periods of gene expression in animal cells. Genes Dev. 2008 Sep 1; 22(17):2342-6.
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  69. Swinburne IA, Silver PA. Intron delays and transcriptional timing during development. Dev Cell. 2008 Mar; 14(3):324-30.
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  70. Brown CR, Kennedy CJ, Delmar VA, Forbes DJ, Silver PA. Global histone acetylation induces functional genomic reorganization at mammalian nuclear pore complexes. Genes Dev. 2008 Mar 1; 22(5):627-39.
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  71. Cironi P, Swinburne IA, Silver PA. Enhancement of cell type specificity by quantitative modulation of a chimeric ligand. J Biol Chem. 2008 Mar 28; 283(13):8469-76.
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  72. Savage DF, Way J, Silver PA. Defossiling fuel: how synthetic biology can transform biofuel production. ACS Chem Biol. 2008 Jan 18; 3(1):13-6.
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  73. Komili S, Silver PA. Coupling and coordination in gene expression processes: a systems biology view. Nat Rev Genet. 2008 Jan; 9(1):38-48.
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  74. Frietze S, Lupien M, Silver PA, Brown M. CARM1 regulates estrogen-stimulated breast cancer growth through up-regulation of E2F1. Cancer Res. 2008 Jan 1; 68(1):301-6.
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  75. Farny NG, Hurt JA, Silver PA. Definition of global and transcript-specific mRNA export pathways in metazoans. Genes Dev. 2008 Jan 1; 22(1):66-78.
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  76. Moore MJ, Silver PA. Global analysis of mRNA splicing. RNA. 2008 Feb; 14(2):197-203.
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  77. Komili S, Farny NG, Roth FP, Silver PA. Functional specificity among ribosomal proteins regulates gene expression. Cell. 2007 Nov 2; 131(3):557-71.
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  78. Ajo-Franklin CM, Drubin DA, Eskin JA, Gee EP, Landgraf D, Phillips I, Silver PA. Rational design of memory in eukaryotic cells. Genes Dev. 2007 Sep 15; 21(18):2271-6.
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  79. Silver PA, Way JC. Molecular systems biology in drug development. Clin Pharmacol Ther. 2007 Nov; 82(5):586-90.
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  80. McKee AE, Silver PA. Systems perspectives on mRNA processing. Cell Res. 2007 Jul; 17(7):581-90.
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  81. Zhou Z, Cironi P, Lin AJ, Xu Y, Hrvatin S, Golan DE, Silver PA, Walsh CT, Yin J. Genetically encoded short peptide tags for orthogonal protein labeling by Sfp and AcpS phosphopantetheinyl transferases. ACS Chem Biol. 2007 May 22; 2(5):337-46.
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  82. Silver PA. Why do so few women speak at science meetings? Nature. 2007 Apr 19; 446(7138):856.
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  83. Brown CR, Silver PA. Transcriptional regulation at the nuclear pore complex. Curr Opin Genet Dev. 2007 Apr; 17(2):100-6.
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  84. Drubin DA, Way JC, Silver PA. Designing biological systems. Genes Dev. 2007 Feb 1; 21(3):242-54.
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  85. McKee AE, Neretti N, Carvalho LE, Meyer CA, Fox EA, Brodsky AS, Silver PA. Exon expression profiling reveals stimulus-mediated exon use in neural cells. Genome Biol. 2007; 8(8):R159.
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  86. Moore MJ, Schwartzfarb EM, Silver PA, Yu MC. Differential recruitment of the splicing machinery during transcription predicts genome-wide patterns of mRNA splicing. Mol Cell. 2006 Dec 28; 24(6):903-15.
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  87. Yu MC, Lamming DW, Eskin JA, Sinclair DA, Silver PA. The role of protein arginine methylation in the formation of silent chromatin. Genes Dev. 2006 Dec 1; 20(23):3249-54.
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  88. Tsankov AM, Brown CR, Yu MC, Win MZ, Silver PA, Casolari JM. Communication between levels of transcriptional control improves robustness and adaptivity. Mol Syst Biol. 2006; 2:65.
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  89. Goffin L, Vodala S, Fraser C, Ryan J, Timms M, Meusburger S, Catimel B, Nice EC, Silver PA, Xiao CY, Jans DA, Gething MJ. The unfolded protein response transducer Ire1p contains a nuclear localization sequence recognized by multiple beta importins. Mol Biol Cell. 2006 Dec; 17(12):5309-23.
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  90. Damelin M, Silver P. Experimental Design for In Vivo FRET Analysis. CSH Protoc. 2006; 2006(5).
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  91. Damelin M, Silver P. Equipment for In Vivo FRET Analysis. CSH Protoc. 2006; 2006(5).
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  92. Damelin M, Silver P. An Explanation of Symbols Used for Analysis of FRET Data. CSH Protoc. 2006; 2006(5).
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  93. Damelin M, Silver P. Analysis of Protein Interactions In Vivo with Fluorescence Resonance Energy Transfer (FRET). CSH Protoc. 2006; 2006(5).
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  94. Carroll JS, Meyer CA, Song J, Li W, Geistlinger TR, Eeckhoute J, Brodsky AS, Keeton EK, Fertuck KC, Hall GF, Wang Q, Bekiranov S, Sementchenko V, Fox EA, Silver PA, Gingeras TR, Liu XS, Brown M. Genome-wide analysis of estrogen receptor binding sites. Nat Genet. 2006 Nov; 38(11):1289-97.
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  95. Arbiser JL, Kau T, Konar M, Narra K, Ramchandran R, Summers SA, Vlahos CJ, Ye K, Perry BN, Matter W, Fischl A, Cook J, Silver PA, Bain J, Cohen P, Whitmire D, Furness S, Govindarajan B, Bowen JP. Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis. Blood. 2007 Jan 15; 109(2):560-5.
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  96. Auld KL, Silver PA. Transcriptional regulation by the proteasome as a mechanism for cellular protein homeostasis. Cell Cycle. 2006 Jul; 5(14):1503-5.
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  97. Auld KL, Hitchcock AL, Doherty HK, Frietze S, Huang LS, Silver PA. The conserved ATPase Get3/Arr4 modulates the activity of membrane-associated proteins in Saccharomyces cerevisiae. Genetics. 2006 Sep; 174(1):215-27.
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  98. Swinburne IA, Meyer CA, Liu XS, Silver PA, Brodsky AS. Genomic localization of RNA binding proteins reveals links between pre-mRNA processing and transcription. Genome Res. 2006 Jul; 16(7):912-21.
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  99. McKee AE, Silver PA. Systems biology of gene regulation fulfills its promise. Genome Biol. 2006; 7(5):316.
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  100. Brown CR, Silver PA. Pore-ing the right dose. Nat Cell Biol. 2006 May; 8(5):430-1.
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  101. Drubin DA, Garakani AM, Silver PA. Motion as a phenotype: the use of live-cell imaging and machine visual screening to characterize transcription-dependent chromosome dynamics. BMC Cell Biol. 2006; 7:19.
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  102. Auld KL, Brown CR, Casolari JM, Komili S, Silver PA. Genomic association of the proteasome demonstrates overlapping gene regulatory activity with transcription factor substrates. Mol Cell. 2006 Mar 17; 21(6):861-71.
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  103. Bachand F, Lackner DH, Bähler J, Silver PA. Autoregulation of ribosome biosynthesis by a translational response in fission yeast. Mol Cell Biol. 2006 Mar; 26(5):1731-42.
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  104. Hitchcock AL, Kahana JA, Silver PA. The uses of green fluorescent protein in yeasts. Methods Biochem Anal. 2006; 47:179-201.
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  105. Gama-Carvalho M, Barbosa-Morais NL, Brodsky AS, Silver PA, Carmo-Fonseca M. Genome-wide identification of functionally distinct subsets of cellular mRNAs associated with two nucleocytoplasmic-shuttling mammalian splicing factors. Genome Biol. 2006; 7(11):R113.
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  106. Vandegraaff N, Devroe E, Turlure F, Silver PA, Engelman A. Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication. Virology. 2006 Mar 15; 346(2):415-26.
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  107. Robinson MA, Park S, Sun ZY, Silver PA, Wagner G, Hogle JM. Multiple conformations in the ligand-binding site of the yeast nuclear pore-targeting domain of Nup116p. J Biol Chem. 2005 Oct 21; 280(42):35723-32.
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  108. McKee AE, Minet E, Stern C, Riahi S, Stiles CD, Silver PA. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. BMC Dev Biol. 2005; 5:14.
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  109. Brodsky AS, Meyer CA, Swinburne IA, Hall G, Keenan BJ, Liu XS, Fox EA, Silver PA. Genomic mapping of RNA polymerase II reveals sites of co-transcriptional regulation in human cells. Genome Biol. 2005; 6(8):R64.
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  110. Carroll JS, Liu XS, Brodsky AS, Li W, Meyer CA, Szary AJ, Eeckhoute J, Shao W, Hestermann EV, Geistlinger TR, Fox EA, Silver PA, Brown M. Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Cell. 2005 Jul 15; 122(1):33-43.
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  111. Park S, Isaacson R, Kim HT, Silver PA, Wagner G. Ufd1 exhibits the AAA-ATPase fold with two distinct ubiquitin interaction sites. Structure. 2005 Jul; 13(7):995-1005.
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  112. Casolari JM, Brown CR, Drubin DA, Rando OJ, Silver PA. Developmentally induced changes in transcriptional program alter spatial organization across chromosomes. Genes Dev. 2005 May 15; 19(10):1188-98.
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  113. Schroeder FC, Kau TR, Silver PA, Clardy J. The psammaplysenes, specific inhibitors of FOXO1a nuclear export. J Nat Prod. 2005 Apr; 68(4):574-6.
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  114. Devroe E, Silver PA, Engelman A. HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases. Virology. 2005 Jan 5; 331(1):181-9.
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  115. Lu R, Limón A, Devroe E, Silver PA, Cherepanov P, Engelman A. Class II integrase mutants with changes in putative nuclear localization signals are primarily blocked at a postnuclear entry step of human immunodeficiency virus type 1 replication. J Virol. 2004 Dec; 78(23):12735-46.
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  116. Hieronymus H, Silver PA. A systems view of mRNP biology. Genes Dev. 2004 Dec 1; 18(23):2845-60.
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  117. Hieronymus H, Yu MC, Silver PA. Genome-wide mRNA surveillance is coupled to mRNA export. Genes Dev. 2004 Nov 1; 18(21):2652-62.
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  118. Cherepanov P, Devroe E, Silver PA, Engelman A. Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase. J Biol Chem. 2004 Nov 19; 279(47):48883-92.
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  119. Turlure F, Devroe E, Silver PA, Engelman A. Human cell proteins and human immunodeficiency virus DNA integration. Front Biosci. 2004 Sep 1; 9:3187-208.
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  120. Yu MC, Bachand F, McBride AE, Komili S, Casolari JM, Silver PA. Arginine methyltransferase affects interactions and recruitment of mRNA processing and export factors. Genes Dev. 2004 Aug 15; 18(16):2024-35.
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  121. Bachand F, Silver PA. PRMT3 is a ribosomal protein methyltransferase that affects the cellular levels of ribosomal subunits. EMBO J. 2004 Jul 7; 23(13):2641-50.
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  122. McKee AE, Silver PA. REF-ereeing the cytoplasmic fate of mRNA via nuclear export. Dev Cell. 2004 Jun; 6(6):740-2.
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  123. Casolari JM, Brown CR, Komili S, West J, Hieronymus H, Silver PA. Genome-wide localization of the nuclear transport machinery couples transcriptional status and nuclear organization. Cell. 2004 May 14; 117(4):427-39.
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  124. Casolari JM, Silver PA. Guardian at the gate: preventing unspliced pre-mRNA export. Trends Cell Biol. 2004 May; 14(5):222-5.
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  125. Devroe E, Erdjument-Bromage H, Tempst P, Silver PA. Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. J Biol Chem. 2004 Jun 4; 279(23):24444-51.
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  126. Devroe E, Silver PA. Therapeutic potential of retroviral RNAi vectors. Expert Opin Biol Ther. 2004 Mar; 4(3):319-27.
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  127. Kau TR, Way JC, Silver PA. Nuclear transport and cancer: from mechanism to intervention. Nat Rev Cancer. 2004 Feb; 4(2):106-17.
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  128. Jiang Y, Minet E, Zhang Z, Silver PA, Bai M. Modulation of interprotomer relationships is important for activation of dimeric calcium-sensing receptor. J Biol Chem. 2004 Apr 2; 279(14):14147-56.
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  129. Kau TR, Schroeder F, Ramaswamy S, Wojciechowski CL, Zhao JJ, Roberts TM, Clardy J, Sellers WR, Silver PA. A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. Cancer Cell. 2003 Dec; 4(6):463-76.
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  130. Haggarty SJ, Koeller KM, Kau TR, Silver PA, Roberge M, Schreiber SL. Small molecule modulation of the human chromatid decatenation checkpoint. Chem Biol. 2003 Dec; 10(12):1267-79.
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  131. Hitchcock AL, Auld K, Gygi SP, Silver PA. A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12735-40.
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  132. Devroe E, Engelman A, Silver PA. Intracellular transport of human immunodeficiency virus type 1 integrase. J Cell Sci. 2003 Nov 1; 116(Pt 21):4401-8.
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  133. Brodsky AS, Johnston AP, Trau M, Silver PA. Analysis of RNA-protein interactions by flow cytometry. Curr Opin Mol Ther. 2003 Jun; 5(3):235-40.
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  134. Lei EP, Stern CA, Fahrenkrog B, Krebber H, Moy TI, Aebi U, Silver PA. Sac3 is an mRNA export factor that localizes to cytoplasmic fibrils of nuclear pore complex. Mol Biol Cell. 2003 Mar; 14(3):836-47.
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  135. Kau TR, Silver PA. Nuclear transport as a target for cell growth. Drug Discov Today. 2003 Jan 15; 8(2):78-85.
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  136. Hieronymus H, Silver PA. Genome-wide analysis of RNA-protein interactions illustrates specificity of the mRNA export machinery. Nat Genet. 2003 Feb; 33(2):155-61.
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  137. Beilharz T, Egan B, Silver PA, Hofmann K, Lithgow T. Bipartite signals mediate subcellular targeting of tail-anchored membrane proteins in Saccharomyces cerevisiae. J Biol Chem. 2003 Mar 7; 278(10):8219-23.
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  138. Brodsky AS, Silver PA. A microbead-based system for identifying and characterizing RNA-protein interactions by flow cytometry. Mol Cell Proteomics. 2002 Dec; 1(12):922-9.
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  139. Damelin M, Silver PA. In situ analysis of spatial relationships between proteins of the nuclear pore complex. Biophys J. 2002 Dec; 83(6):3626-36.
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  140. Lei EP, Silver PA. Intron status and 3'-end formation control cotranscriptional export of mRNA. Genes Dev. 2002 Nov 1; 16(21):2761-6.
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  141. Limón A, Devroe E, Lu R, Ghory HZ, Silver PA, Engelman A. Nuclear localization of human immunodeficiency virus type 1 preintegration complexes (PICs): V165A and R166A are pleiotropic integrase mutants primarily defective for integration, not PIC nuclear import. J Virol. 2002 Nov; 76(21):10598-607.
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  142. Devroe E, Silver PA. Retrovirus-delivered siRNA. BMC Biotechnol. 2002 Aug 28; 2:15.
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  143. Moy TI, Silver PA. Requirements for the nuclear export of the small ribosomal subunit. J Cell Sci. 2002 Jul 15; 115(Pt 14):2985-95.
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  144. Moy TI, Boettner D, Rhodes JC, Silver PA, Askew DS. Identification of a role for Saccharomyces cerevisiae Cgr1p in pre-rRNA processing and 60S ribosome subunit synthesis. Microbiology. 2002 Apr; 148(Pt 4):1081-90.
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  145. Damelin M, Simon I, Moy TI, Wilson B, Komili S, Tempst P, Roth FP, Young RA, Cairns BR, Silver PA. The genome-wide localization of Rsc9, a component of the RSC chromatin-remodeling complex, changes in response to stress. Mol Cell. 2002 Mar; 9(3):563-73.
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  146. Lei EP, Silver PA. Protein and RNA export from the nucleus. Dev Cell. 2002 Mar; 2(3):261-72.
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  147. Valentini SR, Casolari JM, Oliveira CC, Silver PA, McBride AE. Genetic interactions of yeast eukaryotic translation initiation factor 5A (eIF5A) reveal connections to poly(A)-binding protein and protein kinase C signaling. Genetics. 2002 Feb; 160(2):393-405.
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  148. Brodsky AS, Silver PA. Identifying proteins that affect mRNA localization in living cells. Methods. 2002 Feb; 26(2):151-5.
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  149. Damelin M, Silver PA, Corbett AH. Nuclear protein transport. Methods Enzymol. 2002; 351:587-607.
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  150. Hitchcock AL, Krebber H, Frietze S, Lin A, Latterich M, Silver PA. The conserved npl4 protein complex mediates proteasome-dependent membrane-bound transcription factor activation. Mol Biol Cell. 2001 Oct; 12(10):3226-41.
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  151. Lei EP, Krebber H, Silver PA. Messenger RNAs are recruited for nuclear export during transcription. Genes Dev. 2001 Jul 15; 15(14):1771-82.
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  152. McBride AE, Silver PA. State of the arg: protein methylation at arginine comes of age. Cell. 2001 Jul 13; 106(1):5-8.
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  153. Tham WH, Wyithe JS, Ko Ferrigno P, Silver PA, Zakian VA. Localization of yeast telomeres to the nuclear periphery is separable from transcriptional repression and telomere stability functions. Mol Cell. 2001 Jul; 8(1):189-99.
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  154. Kahana JA, Silver PA. Use of the A. victoria green fluorescent protein to study protein dynamics in vivo. Curr Protoc Mol Biol. 2001 May; Chapter 9:Unit9.7C.
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  155. Kahana JA, Silver PA. Use of the A. victoria green fluorescent protein to study protein dynamics in vivo. Curr Protoc Neurosci. 2001 May; Chapter 5:Unit 5.15.
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  156. Kahana JA, Silver PA. Use of the A. victoria green fluorescent protein to study protein dynamics in vivo. Curr Protoc Pharmacol. 2001 May; Chapter 6:Unit 6.6.
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  157. Hood JK, Hwang WW, Silver PA. The Saccharomyces cerevisiae cyclin Clb2p is targeted to multiple subcellular locations by cis- and trans-acting determinants. J Cell Sci. 2001 Feb; 114(Pt 3):589-97.
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  158. Colas P, Cohen B, Ko Ferrigno P, Silver PA, Brent R. Targeted modification and transportation of cellular proteins. Proc Natl Acad Sci U S A. 2000 Dec 5; 97(25):13720-5.
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  159. Weiss VH, McBride AE, Soriano MA, Filman DJ, Silver PA, Hogle JM. The structure and oligomerization of the yeast arginine methyltransferase, Hmt1. Nat Struct Biol. 2000 Dec; 7(12):1165-71.
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  160. Brodsky AS, Silver PA. Pre-mRNA processing factors are required for nuclear export. RNA. 2000 Dec; 6(12):1737-49.
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  161. Stage-Zimmermann T, Schmidt U, Silver PA. Factors affecting nuclear export of the 60S ribosomal subunit in vivo. Mol Biol Cell. 2000 Nov; 11(11):3777-89.
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  162. Prinz WA, Grzyb L, Veenhuis M, Kahana JA, Silver PA, Rapoport TA. Mutants affecting the structure of the cortical endoplasmic reticulum in Saccharomyces cerevisiae. J Cell Biol. 2000 Aug 7; 150(3):461-74.
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  163. Shen EC, Stage-Zimmermann T, Chui P, Silver PA. 7The yeast mRNA-binding protein Npl3p interacts with the cap-binding complex. J Biol Chem. 2000 Aug 4; 275(31):23718-24.
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  164. Hood JK, Silver PA. Diverse nuclear transport pathways regulate cell proliferation and oncogenesis. Biochim Biophys Acta. 2000 Jul 31; 1471(1):M31-41.
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  165. Ferrigno P, Silver PA. Polyglutamine expansions: proteolysis, chaperones, and the dangers of promiscuity. Neuron. 2000 Apr; 26(1):9-12.
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  166. Hood JK, Casolari JM, Silver PA. Nup2p is located on the nuclear side of the nuclear pore complex and coordinates Srp1p/importin-alpha export. J Cell Sci. 2000 Apr; 113 ( Pt 8):1471-80.
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  167. Jones AL, Quimby BB, Hood JK, Ferrigno P, Keshava PH, Silver PA, Corbett AH. SAC3 may link nuclear protein export to cell cycle progression. Proc Natl Acad Sci U S A. 2000 Mar 28; 97(7):3224-9.
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  168. McBride AE, Weiss VH, Kim HK, Hogle JM, Silver PA. Analysis of the yeast arginine methyltransferase Hmt1p/Rmt1p and its in vivo function. Cofactor binding and substrate interactions. J Biol Chem. 2000 Feb 4; 275(5):3128-36.
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  169. Krebber H, Silver PA. Directing proteins to nucleus by fusion to nuclear localization signal tags. Methods Enzymol. 2000; 327:283-96.
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  170. Damelin M, Silver PA. Mapping interactions between nuclear transport factors in living cells reveals pathways through the nuclear pore complex. Mol Cell. 2000 Jan; 5(1):133-40.
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  171. Ferrigno P, Silver PA. Regulated nuclear localization of stress-responsive factors: how the nuclear trafficking of protein kinases and transcription factors contributes to cell survival. Oncogene. 1999 Nov 1; 18(45):6129-34.
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  172. Morehouse H, Buratowski RM, Silver PA, Buratowski S. The importin/karyopherin Kap114 mediates the nuclear import of TATA-binding protein. Proc Natl Acad Sci U S A. 1999 Oct 26; 96(22):12542-7.
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  173. Moy TI, Silver PA. Nuclear export of the small ribosomal subunit requires the ran-GTPase cycle and certain nucleoporins. Genes Dev. 1999 Aug 15; 13(16):2118-33.
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  174. Krebber H, Taura T, Lee MS, Silver PA. Uncoupling of the hnRNP Npl3p from mRNAs during the stress-induced block in mRNA export. Genes Dev. 1999 Aug 1; 13(15):1994-2004.
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  175. Zeng X, Kahana JA, Silver PA, Morphew MK, McIntosh JR, Fitch IT, Carbon J, Saunders WS. Slk19p is a centromere protein that functions to stabilize mitotic spindles. J Cell Biol. 1999 Jul 26; 146(2):415-25.
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  176. Brodsky AS, Silver PA. Nuclear transport HEATs up. Nat Cell Biol. 1999 Jul; 1(3):E66-7.
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  177. Hood JK, Silver PA. In or out? Regulating nuclear transport. Curr Opin Cell Biol. 1999 Apr; 11(2):241-7.
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  178. Defossez PA, Prusty R, Kaeberlein M, Lin SJ, Ferrigno P, Silver PA, Keil RL, Guarente L. Elimination of replication block protein Fob1 extends the life span of yeast mother cells. Mol Cell. 1999 Apr; 3(4):447-55.
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  179. Valentini SR, Weiss VH, Silver PA. Arginine methylation and binding of Hrp1p to the efficiency element for mRNA 3'-end formation. RNA. 1999 Feb; 5(2):272-80.
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  180. Seedorf M, Damelin M, Kahana J, Taura T, Silver PA. Interactions between a nuclear transporter and a subset of nuclear pore complex proteins depend on Ran GTPase. Mol Cell Biol. 1999 Feb; 19(2):1547-57.
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  181. Ferrigno P, Silver PA. Analysis of nuclear transport in vivo. Methods Cell Biol. 1999; 58:107-22.
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  182. Hood JK, Silver PA. Cse1p is required for export of Srp1p/importin-alpha from the nucleus in Saccharomyces cerevisiae. J Biol Chem. 1998 Dec 25; 273(52):35142-6.
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  183. Silberstein S, Schlenstedt G, Silver PA, Gilmore R. A role for the DnaJ homologue Scj1p in protein folding in the yeast endoplasmic reticulum. J Cell Biol. 1998 Nov 16; 143(4):921-33.
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  184. Ferrigno P, Posas F, Koepp D, Saito H, Silver PA. Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin beta homologs NMD5 and XPO1. EMBO J. 1998 Oct 1; 17(19):5606-14.
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  185. Kahana JA, Schlenstedt G, Evanchuk DM, Geiser JR, Hoyt MA, Silver PA. The yeast dynactin complex is involved in partitioning the mitotic spindle between mother and daughter cells during anaphase B. Mol Biol Cell. 1998 Jul; 9(7):1741-56.
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  186. Finley D, Tanaka K, Mann C, Feldmann H, Hochstrasser M, Vierstra R, Johnston S, Hampton R, Haber J, Mccusker J, Silver P, Frontali L, Thorsness P, Varshavsky A, Byers B, Madura K, Reed SI, Wolf D, Jentsch S, Sommer T, Baumeister W, Goldberg A, Fried V, Rubin DM, Toh-e A, et al. Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle. Trends Biochem Sci. 1998 Jul; 23(7):244-5.
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  187. Taura T, Krebber H, Silver PA. A member of the Ran-binding protein family, Yrb2p, is involved in nuclear protein export. Proc Natl Acad Sci U S A. 1998 Jun 23; 95(13):7427-32.
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  188. Webb CD, Graumann PL, Kahana JA, Teleman AA, Silver PA, Losick R. Use of time-lapse microscopy to visualize rapid movement of the replication origin region of the chromosome during the cell cycle in Bacillus subtilis. Mol Microbiol. 1998 Jun; 28(5):883-92.
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  189. Koepp DM, Silver PA. Nucleocytoplasmic transport and cell proliferation. Biochim Biophys Acta. 1998 Apr 17; 1377(2):M39-47.
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  190. Scott HS, Antonarakis SE, Lalioti MD, Rossier C, Silver PA, Henry MF. Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2). Genomics. 1998 Mar 15; 48(3):330-40.
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  191. Shen EC, Henry MF, Weiss VH, Valentini SR, Silver PA, Lee MS. Arginine methylation facilitates the nuclear export of hnRNP proteins. Genes Dev. 1998 Mar 1; 12(5):679-91.
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  192. Huyett A, Kahana J, Silver P, Zeng X, Saunders WS. The Kar3p and Kip2p motors function antagonistically at the spindle poles to influence cytoplasmic microtubule numbers. J Cell Sci. 1998 Feb; 111 ( Pt 3):295-301.
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  193. Vodicka MA, Koepp DM, Silver PA, Emerman M. HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection. Genes Dev. 1998 Jan 15; 12(2):175-85.
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  194. Taura T, Schlenstedt G, Silver PA. Yrb2p is a nuclear protein that interacts with Prp20p, a yeast Rcc1 homologue. J Biol Chem. 1997 Dec 12; 272(50):31877-84.
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  195. Clarkson WD, Corbett AH, Paschal BM, Kent HM, McCoy AJ, Gerace L, Silver PA, Stewart M. Nuclear protein import is decreased by engineered mutants of nuclear transport factor 2 (NTF2) that do not bind GDP-Ran. J Mol Biol. 1997 Oct 10; 272(5):716-30.
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  196. Kessler MM, Henry MF, Shen E, Zhao J, Gross S, Silver PA, Moore CL. Hrp1, a sequence-specific RNA-binding protein that shuttles between the nucleus and the cytoplasm, is required for mRNA 3'-end formation in yeast. Genes Dev. 1997 Oct 1; 11(19):2545-56.
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  197. Seedorf M, Silver PA. Importin/karyopherin protein family members required for mRNA export from the nucleus. Proc Natl Acad Sci U S A. 1997 Aug 5; 94(16):8590-5.
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  198. Wong DH, Corbett AH, Kent HM, Stewart M, Silver PA. Interaction between the small GTPase Ran/Gsp1p and Ntf2p is required for nuclear transport. Mol Cell Biol. 1997 Jul; 17(7):3755-67.
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  199. Corbett AH, Silver PA. Nucleocytoplasmic transport of macromolecules. Microbiol Mol Biol Rev. 1997 Jun; 61(2):193-211.
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  200. Campbell KS, Mullane KP, Aksoy IA, Stubdal H, Zalvide J, Pipas JM, Silver PA, Roberts TM, Schaffhausen BS, DeCaprio JA. DnaJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication. Genes Dev. 1997 May 1; 11(9):1098-110.
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  201. Lee MS, Silver PA. RNA movement between the nucleus and the cytoplasm. Curr Opin Genet Dev. 1997 Apr; 7(2):212-9.
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  202. Lithgow T, Cuezva JM, Silver PA. Highways for protein delivery to the mitochondria. Trends Biochem Sci. 1997 Apr; 22(4):110-3.
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  203. Corbett A, Ferrigno P, Henry M, Kahana J, Koepp D, Lee M, Nguyen L, Schlenstedt G, Seedorf M, Shen E, Taura T, Wong D, Silver P. Genetic analysis of macromolecular transport across the nuclear envelope. Exp Cell Res. 1996 Dec 15; 229(2):212-6.
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  204. DeHoratius C, Silver PA. Nuclear transport defects and nuclear envelope alterations are associated with mutation of the Saccharomyces cerevisiae NPL4 gene. Mol Biol Cell. 1996 Nov; 7(11):1835-55.
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  205. Koepp DM, Silver PA. A GTPase controlling nuclear trafficking: running the right way or walking RANdomly? Cell. 1996 Oct 4; 87(1):1-4.
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  206. Haarer BK, Corbett A, Kweon Y, Petzold AS, Silver P, Brown SS. SEC3 mutations are synthetically lethal with profilin mutations and cause defects in diploid-specific bud-site selection. Genetics. 1996 Oct; 144(2):495-510.
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  207. Corbett AH, Silver PA. The NTF2 gene encodes an essential, highly conserved protein that functions in nuclear transport in vivo. J Biol Chem. 1996 Aug 2; 271(31):18477-84.
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  208. Henry MF, Silver PA. A novel methyltransferase (Hmt1p) modifies poly(A)+-RNA-binding proteins. Mol Cell Biol. 1996 Jul; 16(7):3668-78.
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  209. Koepp DM, Wong DH, Corbett AH, Silver PA. Dynamic localization of the nuclear import receptor and its interactions with transport factors. J Cell Biol. 1996 Jun; 133(6):1163-76.
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  210. Lee MS, Henry M, Silver PA. A protein that shuttles between the nucleus and the cytoplasm is an important mediator of RNA export. Genes Dev. 1996 May 15; 10(10):1233-46.
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  211. Henry M, Borland CZ, Bossie M, Silver PA. Potential RNA binding proteins in Saccharomyces cerevisiae identified as suppressors of temperature-sensitive mutations in NPL3. Genetics. 1996 Jan; 142(1):103-15.
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  212. Schlenstedt G, Wong DH, Koepp DM, Silver PA. Mutants in a yeast Ran binding protein are defective in nuclear transport. EMBO J. 1995 Nov 1; 14(21):5367-78.
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  213. Kahana JA, Schnapp BJ, Silver PA. Kinetics of spindle pole body separation in budding yeast. Proc Natl Acad Sci U S A. 1995 Oct 10; 92(21):9707-11.
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  214. Corbett AH, Koepp DM, Schlenstedt G, Lee MS, Hopper AK, Silver PA. Rna1p, a Ran/TC4 GTPase activating protein, is required for nuclear import. J Cell Biol. 1995 Sep; 130(5):1017-26.
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  215. Loeb JD, Schlenstedt G, Pellman D, Kornitzer D, Silver PA, Fink GR. The yeast nuclear import receptor is required for mitosis. Proc Natl Acad Sci U S A. 1995 Aug 15; 92(17):7647-51.
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  216. Schlenstedt G, Harris S, Risse B, Lill R, Silver PA. A yeast DnaJ homologue, Scj1p, can function in the endoplasmic reticulum with BiP/Kar2p via a conserved domain that specifies interactions with Hsp70s. J Cell Biol. 1995 May; 129(4):979-88.
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  217. Schlenstedt G, Saavedra C, Loeb JD, Cole CN, Silver PA. The GTP-bound form of the yeast Ran/TC4 homologue blocks nuclear protein import and appearance of poly(A)+ RNA in the cytoplasm. Proc Natl Acad Sci U S A. 1995 Jan 3; 92(1):225-9.
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  218. Flach J, Bossie M, Vogel J, Corbett A, Jinks T, Willins DA, Silver PA. A yeast RNA-binding protein shuttles between the nucleus and the cytoplasm. Mol Cell Biol. 1994 Dec; 14(12):8399-407.
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  219. Osborne MA, Schlenstedt G, Jinks T, Silver PA. Nuf2, a spindle pole body-associated protein required for nuclear division in yeast. J Cell Biol. 1994 May; 125(4):853-66.
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  220. Wiedmann B, Silver P, Schunck WH, Wiedmann M. Overexpression of the ER-membrane protein P-450 CYP52A3 mimics sec mutant characteristics in Saccharomyces cerevisiae. Biochim Biophys Acta. 1993 Dec 12; 1153(2):267-76.
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  221. Schlenstedt G, Hurt E, Doye V, Silver PA. Reconstitution of nuclear protein transport with semi-intact yeast cells. J Cell Biol. 1993 Nov; 123(4):785-98.
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  222. Kurihara T, Silver P. Suppression of a sec63 mutation identifies a novel component of the yeast endoplasmic reticulum translocation apparatus. Mol Biol Cell. 1993 Sep; 4(9):919-30.
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  223. Silver PA, Way JC. Eukaryotic DnaJ homologs and the specificity of Hsp70 activity. Cell. 1993 Jul 16; 74(1):5-6.
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  224. Nelson MK, Kurihara T, Silver PA. Extragenic suppressors of mutations in the cytoplasmic C terminus of SEC63 define five genes in Saccharomyces cerevisiae. Genetics. 1993 May; 134(1):159-73.
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  225. Stochaj U, Bossie MA, van Zee K, Whalen AM, Silver PA. Analysis of conserved binding proteins for nuclear localization sequences. J Cell Sci. 1993 Jan; 104 ( Pt 1):89-95.
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  226. Osborne MA, Silver PA. Nucleocytoplasmic transport in the yeast Saccharomyces cerevisiae. Annu Rev Biochem. 1993; 62:219-54.
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  227. Stochaj U, Silver P. Nucleocytoplasmic traffic of proteins. Eur J Cell Biol. 1992 Oct; 59(1):1-11.
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  228. Bossie MA, Silver PA. Movement of macromolecules between the cytoplasm and the nucleus in yeast. Curr Opin Genet Dev. 1992 Oct; 2(5):768-74.
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  229. Bossie MA, DeHoratius C, Barcelo G, Silver P. A mutant nuclear protein with similarity to RNA binding proteins interferes with nuclear import in yeast. Mol Biol Cell. 1992 Aug; 3(8):875-93.
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  230. Stochaj U, Silver PA. A conserved phosphoprotein that specifically binds nuclear localization sequences is involved in nuclear import. J Cell Biol. 1992 May; 117(3):473-82.
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  231. Blumberg H, Silver P. A split zinc-finger protein is required for normal yeast growth. Gene. 1991 Oct 30; 107(1):101-10.
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  232. Stochaj U, Osborne M, Kurihara T, Silver P. A yeast protein that binds nuclear localization signals: purification localization, and antibody inhibition of binding activity. J Cell Biol. 1991 Jun; 113(6):1243-54.
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  233. Blumberg H, Silver PA. A homologue of the bacterial heat-shock gene DnaJ that alters protein sorting in yeast. Nature. 1991 Feb 14; 349(6310):627-30.
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  234. Silver PA. How proteins enter the nucleus. Cell. 1991 Feb 8; 64(3):489-97.
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  235. Sadler I, Chiang A, Kurihara T, Rothblatt J, Way J, Silver P. A yeast gene important for protein assembly into the endoplasmic reticulum and the nucleus has homology to DnaJ, an Escherichia coli heat shock protein. J Cell Biol. 1989 Dec; 109(6 Pt 1):2665-75.
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  236. Silver P, Sadler I, Osborne MA. Yeast proteins that recognize nuclear localization sequences. J Cell Biol. 1989 Sep; 109(3):983-9.
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  237. Nelson M, Silver P. Context affects nuclear protein localization in Saccharomyces cerevisiae. Mol Cell Biol. 1989 Feb; 9(2):384-9.
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  238. Silver P, Goodson H. Nuclear protein transport. Crit Rev Biochem Mol Biol. 1989; 24(4):419-35.
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  239. Silver PA, Chiang A, Sadler I. Mutations that alter both localization and production of a yeast nuclear protein. Genes Dev. 1988 Jun; 2(6):707-17.
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  240. Silver PA, Brent R, Ptashne M. DNA binding is not sufficient for nuclear localization of regulatory proteins in Saccharomyces cerevisiae. Mol Cell Biol. 1986 Dec; 6(12):4763-6.
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  241. Silver PA, Keegan LP, Ptashne M. Amino terminus of the yeast GAL4 gene product is sufficient for nuclear localization. Proc Natl Acad Sci U S A. 1984 Oct; 81(19):5951-5.
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  242. Date T, Silver P, Wickner W. Molecular genetics of Escherichia coli leader peptidase. Methods Enzymol. 1983; 97:46-57.
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  243. Watts C, Goodman JM, Silver P, Wickner W. Analysis of M13 procoat assembly into membranes in vitro. Methods Enzymol. 1983; 97:130-8.
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  244. Watts C, Silver P, Wickner W. Membrane assembly from purified components. II. Assembly of M13 procoat into liposomes reconstituted with purified leader peptidase. Cell. 1981 Aug; 25(2):347-53.
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  245. Silver P, Watts C, Wickner W. Membrane assembly from purified components. I. Isolated M13 procoat does not require ribosomes or soluble proteins for processing by membranes. Cell. 1981 Aug; 25(2):341-5.
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  246. Silver P, Wickner WT. Role of M13 gene 1 protein in filamentous virus assembly. J Virol. 1980 Jul; 35(1):256-8.
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  247. Omar S, Brown MF, Silver P, Schleich T. Histidyl and tyrosyl residue ionization studies of subtilisin Novo. Biochim Biophys Acta. 1979 Jun 19; 578(2):261-8.
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