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Institution

Francis John Hornicek, M.D., PH.D.

TitleAssociate Professor of Orthopedic Surgery
InstitutionMassachusetts General Hospital
DepartmentOrthopedic Surgery
AddressMassachusetts General Hospital
Orthopedic Surgery GRB 604a
55 Fruit St
Boston MA 02114
Phone617/724-7626
Fax617/726-6823

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kobayashi E, Iyer AK, Hornicek FJ, Amiji MM, Duan Z. Lipid-functionalized Dextran Nanosystems to Overcome Multidrug Resistance in Cancer: A Pilot Study. Clin Orthop Relat Res. 2013 Mar; 471(3):915-25.
    View in: PubMed
  2. Raskin KA, Schwab JH, Mankin HJ, Springfield DS, Hornicek FJ. Giant cell tumor of bone. J Am Acad Orthop Surg. 2013 Feb; 21(2):118-26.
    View in: PubMed
  3. Kang J, Botros M, Goldberg S, Giraud C, Nielsen GP, Chen YL, Raskin K, Schwab J, Yoon SS, Hornicek FJ, Delaney TF. The use of radiation therapy in the management of selected patients with atypical lipomas. Sarcoma. 2013; 2013:485483.
    View in: PubMed
  4. Mankin HJ, Hornicek FJ, Delaney TF, Harmon DC, Schiller AL. Pleomorphic spindle cell sarcoma (PSCS) formerly known as malignant fibrous histiocytoma (MFH): a complex malignant soft-tissue tumor. Musculoskelet Surg. 2012 Dec; 96(3):171-7.
    View in: PubMed
  5. Dunn GP, Spiliopoulos K, Plotkin SR, Hornicek FJ, Harmon DC, Delaney TF, Williams Z. Role of resection of malignant peripheral nerve sheath tumors in patients with neurofibromatosis Type 1. J Neurosurg. 2013 Jan; 118(1):142-8.
    View in: PubMed
  6. Hong NJ, Hornicek FJ, Harmon DC, Choy E, Chen YL, Yoon SS, Nielsen GP, Szymonifka J, Yeap BY, Delaney TF, Mullen JT. Neoadjuvant chemoradiotherapy for patients with high-risk extremity and truncal sarcomas: A 10-year single institution retrospective study. Eur J Cancer. 2013 Mar; 49(4):875-83.
    View in: PubMed
  7. Schwab JH, Springfield DS, Raskin KA, Mankin HJ, Hornicek FJ. What's New in Primary Bone Tumors. J Bone Joint Surg Am. 2012 Oct 17; 94(20):1913-9.
    View in: PubMed
  8. Mullen JT, Delaney TF, Kobayashi WK, Szymonifka J, Yeap BY, Chen YL, Rosenberg AE, Harmon DC, Choy E, Yoon SS, Raskin KA, Petur Nielsen G, Hornicek FJ. Desmoid tumor: analysis of prognostic factors and outcomes in a surgical series. Ann Surg Oncol. 2012 Dec; 19(13):4028-35.
    View in: PubMed
  9. Yang W, Liu X, Choy E, Mankin H, Hornicek FJ, Duan Z. Targeting hedgehog-GLI-2 pathway in osteosarcoma. J Orthop Res. 2013 Mar; 31(3):502-9.
    View in: PubMed
  10. Stylianopoulos T, Martin JD, Chauhan VP, Jain SR, Diop-Frimpong B, Bardeesy N, Smith BL, Ferrone CR, Hornicek FJ, Boucher Y, Munn LL, Jain RK. Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors. Proc Natl Acad Sci U S A. 2012 Sep 18; 109(38):15101-8.
    View in: PubMed
  11. Look Hong NJ, Hornicek FJ, Raskin KA, Yoon SS, Szymonifka J, Yeap B, Chen YL, Delaney TF, Nielsen GP, Mullen JT. Prognostic factors and outcomes of patients with myxofibrosarcoma. Ann Surg Oncol. 2013 Jan; 20(1):80-6.
    View in: PubMed
  12. Duan Z, Zhang J, Choy E, Harmon D, Liu X, Nielsen P, Mankin H, Gray NS, Hornicek FJ. Systematic kinome shRNA screening identifies CDK11 (PITSLRE) kinase expression is critical for osteosarcoma cell growth and proliferation. Clin Cancer Res. 2012 Sep 1; 18(17):4580-8.
    View in: PubMed
  13. Liu X, Nielsen GP, Rosenberg AE, Waterman PR, Yang W, Choy E, Sassi S, Yang S, Harmon DC, Yang C, Schwab JH, Kobayashi E, Mankin HJ, Xavier R, Weissleder R, Duan Z, Hornicek FJ. Establishment and characterization of a novel chordoma cell line: CH22. J Orthop Res. 2012 Oct; 30(10):1666-73.
    View in: PubMed
  14. Boyaci B, Hornicek F, Rosenthal D, Mankin H, Pedlow FX, Carrier C, Harms J, Rosenberg A, Schwab J. Sarcoidosis of the spine: a report of five cases and a review of the literature. J Bone Joint Surg Am. 2012 Apr 4; 94(7):e421-5.
    View in: PubMed
  15. Kobayashi E, Hornicek FJ, Duan Z. MicroRNA Involvement in Osteosarcoma. Sarcoma. 2012; 2012:359739.
    View in: PubMed
  16. Duan Z, Li X, Huang H, Yuan W, Zheng SL, Liu X, Zhang Z, Choy E, Harmon D, Mankin H, Hornicek F. Synthesis and Evaluation of (2-(4-Methoxyphenyl)-4-quinolinyl)(2-piperidinyl)methanol (NSC23925) Isomers To Reverse Multidrug Resistance in Cancer. J Med Chem. 2012 Apr 12; 55(7):3113-21.
    View in: PubMed
  17. Peacock ZS, Resnick CM, Susarla SM, Faquin WC, Rosenberg AE, Nielsen GP, Schwab JH, Hornicek F, Ebb DH, Dodson TB, Kaban LB. Do histologic criteria predict biologic behavior of giant cell lesions? J Oral Maxillofac Surg. 2012 Nov; 70(11):2573-80.
    View in: PubMed
  18. Schoenfeld AJ, Hornicek FJ, Pedlow FX, Kobayashi W, Raskin KA, Springfield D, DeLaney TF, Nielsen GP, Mankin HJ, Schwab JH. Chondrosarcoma of the mobile spine: a review of 21 cases treated at a single center. Spine (Phila Pa 1976). 2012 Jan 15; 37(2):119-26.
    View in: PubMed
  19. Mullen JT, Kobayashi W, Wang JJ, Harmon DC, Choy E, Hornicek FJ, Rosenberg AE, Chen YL, Spiro IJ, DeLaney TF. Long-term follow-up of patients treated with neoadjuvant chemotherapy and radiotherapy for large, extremity soft tissue sarcomas. Cancer. 2012 Aug 1; 118(15):3758-65.
    View in: PubMed
  20. Choy E, Hornicek F, MacConaill L, Harmon D, Tariq Z, Garraway L, Duan Z. High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes. Cancer. 2012 Jun 1; 118(11):2905-14.
    View in: PubMed
  21. Duan Z, Choy E, Harmon D, Liu X, Susa M, Mankin H, Hornicek F. MicroRNA-199a-3p is downregulated in human osteosarcoma and regulates cell proliferation and migration. Mol Cancer Ther. 2011 Aug; 10(8):1337-45.
    View in: PubMed
  22. Hartzell TL, Medina M, Hornicek FJ, Austen WG. Extended dermal apposition: a simple technique for the closure of irradiated perineal and sacral wounds. Plast Reconstr Surg. 2011 Jun; 127(6):170e-3e.
    View in: PubMed
  23. Liu X, Choy E, Harmon D, Yang S, Yang C, Mankin H, Hornicek FJ, Duan Z. Inhibition of polo-like kinase 1 leads to the suppression of osteosarcoma cell growth in vitro and in vivo. Anticancer Drugs. 2011 Jun; 22(5):444-53.
    View in: PubMed
  24. Le LP, Nielsen GP, Rosenberg AE, Thomas D, Batten JM, Deshpande V, Schwab J, Duan Z, Xavier RJ, Hornicek FJ, Iafrate AJ. Recurrent chromosomal copy number alterations in sporadic chordomas. PLoS One. 2011; 6(5):e18846.
    View in: PubMed
  25. Yang C, Choy E, Hornicek FJ, Wood KB, Schwab JH, Liu X, Mankin H, Duan Z. Histone deacetylase inhibitor PCI-24781 enhances chemotherapy-induced apoptosis in multidrug-resistant sarcoma cell lines. Anticancer Res. 2011 Apr; 31(4):1115-23.
    View in: PubMed
  26. Ciernik IF, Niemierko A, Harmon DC, Kobayashi W, Chen YL, Yock TI, Ebb DH, Choy E, Raskin KA, Liebsch N, Hornicek FJ, Delaney TF. Proton-based radiotherapy for unresectable or incompletely resected osteosarcoma. Cancer. 2011 Oct 1; 117(19):4522-30.
    View in: PubMed
  27. Liu X, Choy E, Hornicek FJ, Yang S, Yang C, Harmon D, Mankin H, Duan Z. ROCK1 as a potential therapeutic target in osteosarcoma. J Orthop Res. 2011 Aug; 29(8):1259-66.
    View in: PubMed
  28. Henderson ER, Groundland JS, Pala E, Dennis JA, Wooten R, Cheong D, Windhager R, Kotz RI, Mercuri M, Funovics PT, Hornicek FJ, Temple HT, Ruggieri P, Letson GD. Failure mode classification for tumor endoprostheses: retrospective review of five institutions and a literature review. J Bone Joint Surg Am. 2011 Mar 2; 93(5):418-29.
    View in: PubMed
  29. Mankin H, Trahan C, Hornicek F. Pigmented villonodular synovitis of joints. J Surg Oncol. 2011 Apr; 103(5):386-9.
    View in: PubMed
  30. DeLaney TF, Duan Z, Hornicek FJ. Proteomic profiling of chordoma. J Surg Oncol. 2010 Dec 1; 102(7):719.
    View in: PubMed
  31. Yoon SS, Duda DG, Karl DL, Kim TM, Kambadakone AR, Chen YL, Rothrock C, Rosenberg AE, Nielsen GP, Kirsch DG, Choy E, Harmon DC, Hornicek FJ, Dreyfuss J, Ancukiewicz M, Sahani DV, Park PJ, Jain RK, Delaney TF. Phase II study of neoadjuvant bevacizumab and radiotherapy for resectable soft tissue sarcomas. Int J Radiat Oncol Biol Phys. 2011 Nov 15; 81(4):1081-90.
    View in: PubMed
  32. Mankin HJ, Hornicek FJ, Springfield DS. Extra-abdominal desmoid tumors: a report of 234 cases. J Surg Oncol. 2010 Oct 1; 102(5):380-4.
    View in: PubMed
  33. Susa M, Choy E, Liu X, Schwab J, Hornicek FJ, Mankin H, Duan Z. Cyclin G-associated kinase is necessary for osteosarcoma cell proliferation and receptor trafficking. Mol Cancer Ther. 2010 Dec; 9(12):3342-50.
    View in: PubMed
  34. Devisetty K, Kobayashi W, Suit HD, Goldberg SI, Niemierko A, Chen YL, Raskin KA, Schwab JH, Springfield DS, Yoon SS, Hornicek FJ, DeLaney TF. Low-dose neoadjuvant external beam radiation therapy for soft tissue sarcoma. Int J Radiat Oncol Biol Phys. 2011 Jul 1; 80(3):779-86.
    View in: PubMed
  35. Tejwani A, Kobayashi W, Chen YL, Rosenberg AE, Yoon S, Raskin KA, Rosenthal DI, Nielsen GP, Hornicek FJ, Delaney TF. Management of acral myxoinflammatory fibroblastic sarcoma. Cancer. 2010 Dec 15; 116(24):5733-9.
    View in: PubMed
  36. Yang C, Hornicek FJ, Wood KB, Schwab JH, Choy E, Mankin H, Duan Z. Blockage of Stat3 with CDDO-Me inhibits tumor cell growth in chordoma. Spine (Phila Pa 1976). 2010 Aug 15; 35(18):1668-75.
    View in: PubMed
  37. Guo Y, Nemeth J, O'Brien C, Susa M, Liu X, Zhang Z, Choy E, Mankin H, Hornicek F, Duan Z. Effects of siltuximab on the IL-6-induced signaling pathway in ovarian cancer. Clin Cancer Res. 2010 Dec 1; 16(23):5759-69.
    View in: PubMed
  38. Schoenfeld AJ, Hornicek FJ, Pedlow FX, Kobayashi W, Garcia RT, DeLaney TF, Springfield D, Mankin HJ, Schwab JH. Osteosarcoma of the spine: experience in 26 patients treated at the Massachusetts General Hospital. Spine J. 2010 Aug; 10(8):708-14.
    View in: PubMed
  39. Ryu K, Choy E, Yang C, Susa M, Hornicek FJ, Mankin H, Duan Z. Activation of signal transducer and activator of transcription 3 (Stat3) pathway in osteosarcoma cells and overexpression of phosphorylated-Stat3 correlates with poor prognosis. J Orthop Res. 2010 Jul; 28(7):971-8.
    View in: PubMed
  40. Duan Z, Choy E, Nielsen GP, Rosenberg A, Iafrate J, Yang C, Schwab J, Mankin H, Xavier R, Hornicek FJ. Differential expression of microRNA (miRNA) in chordoma reveals a role for miRNA-1 in Met expression. J Orthop Res. 2010 Jun; 28(6):746-52.
    View in: PubMed
  41. Yang C, Hornicek FJ, Wood KB, Schwab JH, Choy E, Iafrate J, Rosenberg A, Nielsen GP, Xavier RJ, Mankin H, Duan Z. Characterization and analysis of human chordoma cell lines. Spine (Phila Pa 1976). 2010 Jun 1; 35(13):1257-64.
    View in: PubMed
  42. Biermann JS, Adkins DR, Benjamin RS, Brigman B, Chow W, Conrad EU, Frassica DA, Frassica FJ, George S, Hande KR, Hornicek FJ, Letson GD, Mayerson J, McGarry SV, McGrath B, Morris CD, O'Donnell RJ, Randall RL, Santana VM, Satcher RL, Siegel HJ, Somaiah N, Yasko AW. Bone cancer. J Natl Compr Canc Netw. 2010 Jun; 8(6):688-712.
    View in: PubMed
  43. Susa M, Milane L, Amiji MM, Hornicek FJ, Duan Z. Nanoparticles: a promising modality in the treatment of sarcomas. Pharm Res. 2011 Feb; 28(2):260-72.
    View in: PubMed
  44. Susa M, Iyer AK, Ryu K, Choy E, Hornicek FJ, Mankin H, Milane L, Amiji MM, Duan Z. Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma. PLoS One. 2010; 5(5):e10764.
    View in: PubMed
  45. Yang C, Choy E, Hornicek FJ, Wood KB, Schwab JH, Liu X, Mankin H, Duan Z. Histone deacetylase inhibitor (HDACI) PCI-24781 potentiates cytotoxic effects of doxorubicin in bone sarcoma cells. Cancer Chemother Pharmacol. 2011 Feb; 67(2):439-46.
    View in: PubMed
  46. Ryu K, Susa M, Choy E, Yang C, Hornicek FJ, Mankin HJ, Duan Z. Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway. BMC Cancer. 2010; 10:187.
    View in: PubMed
  47. Schoenfeld AJ, Koplin SA, Garcia R, Hornicek FJ, Mankin HJ, Raskin KA, Springfield D, Rosenberg AE, Schwab JH. Monostotic fibrous dysplasia of the spine: a report of seven cases. J Bone Joint Surg Am. 2010 Apr; 92(4):984-8.
    View in: PubMed
  48. Susa M, Choy E, Yang C, Schwab J, Mankin H, Hornicek F, Duan Z. Multidrug resistance reversal agent, NSC77037, identified with a cell-based screening assay. J Biomol Screen. 2010 Mar; 15(3):287-96.
    View in: PubMed
  49. Duan Z, Ji D, Weinstein EJ, Liu X, Susa M, Choy E, Yang C, Mankin H, Hornicek FJ. Lentiviral shRNA screen of human kinases identifies PLK1 as a potential therapeutic target for osteosarcoma. Cancer Lett. 2010 Jul 28; 293(2):220-9.
    View in: PubMed
  50. Resnick CM, Margolis J, Susarla SM, Schwab JH, Hornicek FJ, Dodson TB, Kaban LB. Maxillofacial and axial/appendicular giant cell lesions: unique tumors or variants of the same disease?--A comparison of phenotypic, clinical, and radiographic characteristics. J Oral Maxillofac Surg. 2010 Jan; 68(1):130-7.
    View in: PubMed
  51. Yang C, Ji D, Weinstein EJ, Choy E, Hornicek FJ, Wood KB, Liu X, Mankin H, Duan Z. The kinase Mirk is a potential therapeutic target in osteosarcoma. Carcinogenesis. 2010 Apr; 31(4):552-8.
    View in: PubMed
  52. Koplin SA, Nielsen GP, Hornicek FJ, Rosenberg AE. Epithelioid sarcoma with heterotopic bone: a morphologic review of 4 cases. Int J Surg Pathol. 2010 Jun; 18(3):207-12.
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  53. Kim B, Chen YL, Kirsch DG, Goldberg SI, Kobayashi W, Kung JH, Wolfgang JA, Doppke K, Rosenberg AE, Nielsen GP, Raskin KA, Springfield DS, Schwab JH, Gebhardt MC, Yoon SS, Hornicek FJ, DeLaney TF. An effective preoperative three-dimensional radiotherapy target volume for extremity soft tissue sarcoma and the effect of margin width on local control. Int J Radiat Oncol Biol Phys. 2010 Jul 1; 77(3):843-50.
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  54. Mito JK, Riedel RF, Dodd L, Lahat G, Lazar AJ, Dodd RD, Stangenberg L, Eward WC, Hornicek FJ, Yoon SS, Brigman BE, Jacks T, Lev D, Mukherjee S, Kirsch DG. Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma. PLoS One. 2009; 4(11):e8075.
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  55. Susa M, Iyer AK, Ryu K, Hornicek FJ, Mankin H, Amiji MM, Duan Z. Doxorubicin loaded Polymeric Nanoparticulate Delivery System to overcome drug resistance in osteosarcoma. BMC Cancer. 2009; 9:399.
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  56. Duan Z, Choy E, Hornicek FJ. NSC23925, identified in a high-throughput cell-based screen, reverses multidrug resistance. PLoS One. 2009; 4(10):e7415.
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  57. Duan Z, Choy E, Harmon D, Yang C, Ryu K, Schwab J, Mankin H, Hornicek FJ. ZNF93 increases resistance to ET-743 (Trabectedin; Yondelis) and PM00104 (Zalypsis) in human cancer cell lines. PLoS One. 2009; 4(9):e6967.
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  58. Yang C, Schwab JH, Schoenfeld AJ, Hornicek FJ, Wood KB, Nielsen GP, Choy E, Mankin H, Duan Z. A novel target for treatment of chordoma: signal transducers and activators of transcription 3. Mol Cancer Ther. 2009 Sep; 8(9):2597-605.
    View in: PubMed
  59. Duan Z, Choy E, Harmon D, Yang C, Ryu K, Schwab J, Mankin H, Hornicek FJ. Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines. Mol Cancer Ther. 2009 Aug; 8(8):2122-30.
    View in: PubMed
  60. Schwab J, Antonescu C, Boland P, Healey J, Rosenberg A, Nielsen P, Iafrate J, Delaney T, Yoon S, Choy E, Harmon D, Raskin K, Yang C, Mankin H, Springfield D, Hornicek F, Duan Z. Combination of PI3K/mTOR inhibition demonstrates efficacy in human chordoma. Anticancer Res. 2009 Jun; 29(6):1867-71.
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  61. Susa M, Morii T, Yabe H, Horiuchi K, Toyama Y, Weissbach L, Hornicek FJ, Morioka H. Alendronate inhibits growth of high-grade chondrosarcoma cells. Anticancer Res. 2009 Jun; 29(6):1879-88.
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  62. Han S, Polizzano C, Nielsen GP, Hornicek FJ, Rosenberg AE, Ramesh V. Aberrant hyperactivation of akt and Mammalian target of rapamycin complex 1 signaling in sporadic chordomas. Clin Cancer Res. 2009 Mar 15; 15(6):1940-6.
    View in: PubMed
  63. Maduekwe UN, Hornicek FJ, Springfield DS, Raskin KA, Harmon DC, Choy E, Rosenberg AE, Nielsen GP, DeLaney TF, Chen YL, Ott MJ, Yoon SS. Role of sentinel lymph node biopsy in the staging of synovial, epithelioid, and clear cell sarcomas. Ann Surg Oncol. 2009 May; 16(5):1356-63.
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  64. Yang C, Hornicek FJ, Wood KB, Schwab JH, Mankin H, Duan Z. RAIDD expression is impaired in multidrug resistant osteosarcoma cell lines. Cancer Chemother Pharmacol. 2009 Aug; 64(3):607-14.
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  65. Raskin KA, Hornicek F. Allograft reconstruction in malignant bone tumors: indications and limits. Recent Results Cancer Res. 2009; 179:51-8.
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  66. Wagner TD, Kobayashi W, Dean S, Goldberg SI, Kirsch DG, Suit HD, Hornicek FJ, Pedlow FX, Raskin KA, Springfield DS, Yoon SS, Gebhardt MC, Mankin HJ, Delaney TF. Combination short-course preoperative irradiation, surgical resection, and reduced-field high-dose postoperative irradiation in the treatment of tumors involving the bone. Int J Radiat Oncol Biol Phys. 2009 Jan 1; 73(1):259-66.
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  67. Yang C, Yang S, Wood KB, Hornicek FJ, Schwab JH, Fondren G, Mankin H, Duan Z. Multidrug resistant osteosarcoma cell lines exhibit deficiency of GADD45alpha expression. Apoptosis. 2009 Jan; 14(1):124-33.
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  68. Sapkota BH, Hirsch AE, Yoo AJ, Hornicek FJ, Raskin KA, Rosenthal DI, Growney ML, Hirsch JA. Treatment of metastatic carcinoma to the hip with CT-guided percutaneous acetabuloplasty: report of four cases. J Vasc Interv Radiol. 2009 Apr; 20(4):548-52.
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  69. DeLaney TF, Liebsch NJ, Pedlow FX, Adams J, Dean S, Yeap BY, McManus P, Rosenberg AE, Nielsen GP, Harmon DC, Spiro IJ, Raskin KA, Suit HD, Yoon SS, Hornicek FJ. Phase II study of high-dose photon/proton radiotherapy in the management of spine sarcomas. Int J Radiat Oncol Biol Phys. 2009 Jul 1; 74(3):732-9.
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  70. Duan Z, Choy E, Jimeno JM, Cuevas Cdel M, Mankin HJ, Hornicek FJ. Diverse cross-resistance phenotype to ET-743 and PM00104 in multi-drug resistant cell lines. Cancer Chemother Pharmacol. 2009 May; 63(6):1121-9.
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  71. Kaufman AM, Abraham JA, Kattapuram SV, Hornicek FJ. Orthopaedic . radiology . pathology conference: Chronic multifocal chest and leg pain in a 34-year-old woman. Clin Orthop Relat Res. 2009 Apr; 467(4):1112-7.
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  72. Berry M, Mankin H, Gebhardt M, Rosenberg A, Hornicek F. Osteoblastoma: a 30-year study of 99 cases. J Surg Oncol. 2008 Sep 1; 98(3):179-83.
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  73. Hartzell TL, Hornicek FJ, Austen WG. Latissimus dorsi flap closure of the irradiated clavicular wound. J Shoulder Elbow Surg. 2008 Nov-Dec; 17(6):875-80.
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  74. Duan Z, Weinstein EJ, Ji D, Ames RY, Choy E, Mankin H, Hornicek FJ. Lentiviral short hairpin RNA screen of genes associated with multidrug resistance identifies PRP-4 as a new regulator of chemoresistance in human ovarian cancer. Mol Cancer Ther. 2008 Aug; 7(8):2377-85.
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  75. Sung AD, Anderson ME, Zurakowski D, Hornicek FJ, Gebhardt MC. Unicameral bone cyst: a retrospective study of three surgical treatments. Clin Orthop Relat Res. 2008 Oct; 466(10):2519-26.
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  76. Parrett BM, Winograd JM, Garfein ES, Lee WP, Hornicek FJ, Austen WG. The vertical and extended rectus abdominis myocutaneous flap for irradiated thigh and groin defects. Plast Reconstr Surg. 2008 Jul; 122(1):171-7.
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  77. Duan Z, Ames RY, Ryan M, Hornicek FJ, Mankin H, Seiden MV. CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells. Cancer Chemother Pharmacol. 2009 Mar; 63(4):681-9.
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  78. Sawamura C, Hornicek FJ, Gebhardt MC. Complications and risk factors for failure of rotationplasty: review of 25 patients. Clin Orthop Relat Res. 2008 Jun; 466(6):1302-8.
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  79. Kharrazi FD, Busfield BT, Khorshad DS, Hornicek FJ, Mankin HJ. Knee mass from severe metallosis after failure of a metal-backed patellar component total knee arthroplasty. Am J Orthop (Belle Mead NJ). 2008 Feb; 37(2):E38-41.
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  80. Kharrazi FD, Busfield BT, Khorshad DS, Hornicek FJ, Mankin HJ. Osteoarticular and total elbow allograft reconstruction with severe bone loss. Clin Orthop Relat Res. 2008 Jan; 466(1):205-9.
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  81. Hornicek FJ. RE: local control in nonmetastatic pelvic Ewing's sarcoma patients: Outcome and analysis, by Donati, D, et al. J Surg Oncol. 2007 Nov 1; 96(6):453-4.
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  82. Bredella MA, Torriani M, Hornicek F, Ouellette HA, Plamer WE, Williams Z, Fischman AJ, Plotkin SR. Value of PET in the assessment of patients with neurofibromatosis type 1. AJR Am J Roentgenol. 2007 Oct; 189(4):928-35.
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  83. Kirsch DG, Dinulescu DM, Miller JB, Grimm J, Santiago PM, Young NP, Nielsen GP, Quade BJ, Chaber CJ, Schultz CP, Takeuchi O, Bronson RT, Crowley D, Korsmeyer SJ, Yoon SS, Hornicek FJ, Weissleder R, Jacks T. A spatially and temporally restricted mouse model of soft tissue sarcoma. Nat Med. 2007 Aug; 13(8):992-7.
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  84. Geller DS, Hornicek FJ, Mankin HJ, Raskin KA. Soft tissue sarcoma resection volume associated with wound-healing complications. Clin Orthop Relat Res. 2007 Jun; 459:182-5.
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  85. Sah AP, Geller DS, Mankin HJ, Rosenberg AE, Delaney TF, Wright CD, Hornicek FJ. Malignant transformation of synovial chondromatosis of the shoulder to chondrosarcoma. A case report. J Bone Joint Surg Am. 2007 Jun; 89(6):1321-8.
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  86. Mourikis A, Mankin HJ, Hornicek FJ, Raskin KA. Treatment of proximal humeral chondrosarcoma with resection and allograft. J Shoulder Elbow Surg. 2007 Sep-Oct; 16(5):519-24.
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  87. Malchau SS, Hayden J, Hornicek F, Mankin HJ. Clear cell sarcoma of soft tissues. J Surg Oncol. 2007 May 1; 95(6):519-22.
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  88. Kattapuram TM, Ozhathil DK, Hornicek FJ, Gebhardt MC, Mankin HJ, Rosenberg AE, Kattapuram SV. Imaging of pseudoneoplastic masses associated with allografts. Skeletal Radiol. 2007 Aug; 36(8):747-53.
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  89. Delaney TF, Kepka L, Goldberg SI, Hornicek FJ, Gebhardt MC, Yoon SS, Springfield DS, Raskin KA, Harmon DC, Kirsch DG, Mankin HJ, Rosenberg AE, Nielsen GP, Suit HD. Radiation therapy for control of soft-tissue sarcomas resected with positive margins. Int J Radiat Oncol Biol Phys. 2007 Apr 1; 67(5):1460-9.
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  90. Abraham JA, Hornicek FJ, Kaufman AM, Harmon DC, Springfield DS, Raskin KA, Mankin HJ, Kirsch DG, Rosenberg AE, Nielsen GP, Desphpande V, Suit HD, DeLaney TF, Yoon SS. Treatment and outcome of 82 patients with angiosarcoma. Ann Surg Oncol. 2007 Jun; 14(6):1953-67.
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  91. Buecker PJ, Berenstein M, Gebhardt MC, Hornicek FJ, Mankin HJ. Locking versus standard plates for allograft fixation after tumor resection in children and adolescents. J Pediatr Orthop. 2006 Sep-Oct; 26(5):680-5.
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  92. Park L, Delaney TF, Liebsch NJ, Hornicek FJ, Goldberg S, Mankin H, Rosenberg AE, Rosenthal DI, Suit HD. Sacral chordomas: Impact of high-dose proton/photon-beam radiation therapy combined with or without surgery for primary versus recurrent tumor. Int J Radiat Oncol Biol Phys. 2006 Aug 1; 65(5):1514-21.
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  93. Campbell J, Rosenthal DI, Raskin KA, Hornicek FJ, Michaelson MD. Use of an arterial tourniquet to achieve complete radiofrequency ablation of a renal metastasis. J Vasc Interv Radiol. 2006 Jun; 17(6):1051-5.
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  94. Buecker PJ, Villafuerte JE, Hornicek FJ, Gebhardt MC, Mankin HJ. Improved survival for sarcomas of the wrist and hand. J Hand Surg Am. 2006 Mar; 31(3):452-5.
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  95. Kepka L, Suit HD, Goldberg SI, Rosenberg AE, Gebhardt MC, Hornicek FJ, Delaney TF. Results of radiation therapy performed after unplanned surgery (without re-excision) for soft tissue sarcomas. J Surg Oncol. 2005 Oct 1; 92(1):39-45.
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  96. Mankin HJ, Hornicek FJ. Treatment of giant cell tumors with allograft transplants: a 30-year study. Clin Orthop Relat Res. 2005 Oct; 439:144-50.
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  97. Lersundi A, Mankin HJ, Mourikis A, Hornicek FJ. Chondromyxoid fibroma: a rarely encountered and puzzling tumor. Clin Orthop Relat Res. 2005 Oct; 439:171-5.
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  98. Mankin HJ, Hornicek FJ, Ortiz-Cruz E, Villafuerte J, Gebhardt MC. Aneurysmal bone cyst: a review of 150 patients. J Clin Oncol. 2005 Sep 20; 23(27):6756-62.
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  99. Mankin HJ, Hornicek FJ, Harris M. Total femur replacement procedures in tumor treatment. Clin Orthop Relat Res. 2005 Sep; 438:60-4.
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  100. Anderson ME, Hornicek FJ, Gebhardt MC, Raskin KA, Mankin HJ. Alveolar soft part sarcoma: a rare and enigmatic entity. Clin Orthop Relat Res. 2005 Sep; 438:144-8.
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  101. Mankin HJ, Hornicek FJ. Paget's sarcoma: a historical and outcome review. Clin Orthop Relat Res. 2005 Sep; 438:97-102.
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  102. Mankin HJ, Hornicek FJ. Internal hemipelvectomy for the management of pelvic sarcomas. Surg Oncol Clin N Am. 2005 Apr; 14(2):381-96.
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  103. Mankin HJ, Hornicek FJ, Raskin KA. Infection in massive bone allografts. Clin Orthop Relat Res. 2005 Mar; (432):210-6.
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  104. Mankin HJ, Hornicek FJ. Diagnosis, classification, and management of soft tissue sarcomas. Cancer Control. 2005 Jan-Feb; 12(1):5-21.
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  105. Mankin HJ, Hornicek FJ, Rosenberg AE, Harmon DC, Gebhardt MC. Survival data for 648 patients with osteosarcoma treated at one institution. Clin Orthop Relat Res. 2004 Dec; (429):286-91.
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  106. Mankin HJ, Gunnoe J, Farid Y, Hornicek FJ, Gebhardt MC. Long-term effects of connective tissue cancer treatment. Clin Orthop Relat Res. 2004 Sep; (426):74-86.
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  107. Cashen DV, Parisien RC, Raskin K, Hornicek FJ, Gebhardt MC, Mankin HJ. Survival data for patients with malignant schwannoma. Clin Orthop Relat Res. 2004 Sep; (426):69-73.
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  108. Mankin HJ, Hornicek FJ, Temple HT, Gebhardt MC. Malignant tumors of the pelvis: an outcome study. Clin Orthop Relat Res. 2004 Aug; (425):212-7.
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  109. Young-In Lee F, Hornicek FJ, Dick HM, Mankin HJ. Synovial chondromatosis of the foot. Clin Orthop Relat Res. 2004 Jun; (423):186-90.
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  110. Lewandrowski KU, Hecht AC, DeLaney TF, Chapman PA, Hornicek FJ, Pedlow FX. Anterior spinal arthrodesis with structural cortical allografts and instrumentation for spine tumor surgery. Spine (Phila Pa 1976). 2004 May 15; 29(10):1150-8; discussion 1159.
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  111. Zeytoonjian T, Mankin HJ, Gebhardt MC, Hornicek FJ. Distal lower extremity sarcomas: frequency of occurrence and patient survival rate. Foot Ankle Int. 2004 May; 25(5):325-30.
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  112. Brigman BE, Hornicek FJ, Gebhardt MC, Mankin HJ. Allografts about the Knee in Young Patients with High-Grade Sarcoma. Clin Orthop Relat Res. 2004 Apr; (421):232-9.
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  113. Mankin HJ, Casas-Ganem J, Kim JI, Gebhardt MC, Hornicek FJ, Zeegen EN. Leiomyosarcoma of somatic soft tissues. Clin Orthop Relat Res. 2004 Apr; (421):225-31.
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  114. Zeegen EN, Aponte-Tinao LA, Hornicek FJ, Gebhardt MC, Mankin HJ. Survivorship analysis of 141 modular metallic endoprostheses at early followup. Clin Orthop Relat Res. 2004 Mar; (420):239-50.
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  115. Shao L, Kasanov J, Hornicek FJ, Morii T, Fondren G, Weissbach L. Ecteinascidin-743 drug resistance in sarcoma cells: transcriptional and cellular alterations. Biochem Pharmacol. 2003 Dec 15; 66(12):2381-95.
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  116. DeLaney TF, Chen GT, Mauceri TC, Munro JJ, Hornicek FJ, Pedlow FX, Suit HD. Intraoperative dural irradiation by customized 192iridium and 90yttrium brachytherapy plaques. Int J Radiat Oncol Biol Phys. 2003 Sep 1; 57(1):239-45.
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  117. Rosenthal DI, Hornicek FJ, Torriani M, Gebhardt MC, Mankin HJ. Osteoid osteoma: percutaneous treatment with radiofrequency energy. Radiology. 2003 Oct; 229(1):171-5.
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  118. DeLaney TF, Spiro IJ, Suit HD, Gebhardt MC, Hornicek FJ, Mankin HJ, Rosenberg AL, Rosenthal DI, Miryousefi F, Ancukiewicz M, Harmon DC. Neoadjuvant chemotherapy and radiotherapy for large extremity soft-tissue sarcomas. Int J Radiat Oncol Biol Phys. 2003 Jul 15; 56(4):1117-27.
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  119. Morioka H, Morii T, Vogel T, Hornicek FJ, Weissbach L. Interaction of plasminogen-related protein B with endothelial and smooth muscle cells in vitro. Exp Cell Res. 2003 Jul 1; 287(1):166-77.
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  120. Rodriguez EK, Hornicek FJ, Gebhardt MC, Mankin HJ. Metachronous osteosarcoma: a report of five cases. Clin Orthop Relat Res. 2003 Jun; (411):227-35.
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  121. Morioka H, Weissbach L, Vogel T, Nielsen GP, Faircloth GT, Shao L, Hornicek FJ. Antiangiogenesis treatment combined with chemotherapy produces chondrosarcoma necrosis. Clin Cancer Res. 2003 Mar; 9(3):1211-7.
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  122. Rosenthal DI, Marota JJ, Hornicek FJ. Osteoid osteoma: elevation of cardiac and respiratory rates at biopsy needle entry into tumor in 10 patients. Radiology. 2003 Jan; 226(1):125-8.
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  123. Kaban LB, Troulis MJ, Ebb D, August M, Hornicek FJ, Dodson TB. Antiangiogenic therapy with interferon alpha for giant cell lesions of the jaws. J Oral Maxillofac Surg. 2002 Oct; 60(10):1103-11; discussion 1111-3.
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  124. Tang P, Hornicek FJ, Gebhardt MC, Cates J, Mankin HJ. Surgical treatment of hemangiomas of soft tissue. Clin Orthop Relat Res. 2002 Jun; (399):205-10.
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  125. Sami S, Liu G, Hornicek F, Cates JM, Mankin HJ. Membranous lipodystrophy. A case report. J Bone Joint Surg Am. 2002 Apr; 84-A(4):630-3.
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  126. Fox EJ, Hau MA, Gebhardt MC, Hornicek FJ, Tomford WW, Mankin HJ. Long-term followup of proximal femoral allografts. Clin Orthop Relat Res. 2002 Apr; (397):106-13.
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  127. Mankin HJ, Fondren G, Hornicek FJ, Gebhardt MC, Rosenberg AE. The use of flow cytometry in assessing malignancy in bone and soft tissue tumors. Clin Orthop Relat Res. 2002 Apr; (397):95-105.
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  128. Refaat Y, Gunnoe J, Hornicek FJ, Mankin HJ. Comparison of quality of life after amputation or limb salvage. Clin Orthop Relat Res. 2002 Apr; (397):298-305.
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  129. Hau A, Kim I, Kattapuram S, Hornicek FJ, Rosenberg AE, Gebhardt MC, Mankin HJ. Accuracy of CT-guided biopsies in 359 patients with musculoskeletal lesions. Skeletal Radiol. 2002 Jun; 31(6):349-53.
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  130. Berven S, Zurakowski D, Mankin HJ, Gebhardt MC, Springfield DS, Hornicek FJ. Clinical outcome in chordoma: utility of flow cytometry in DNA determination. Spine (Phila Pa 1976). 2002 Feb 15; 27(4):374-9.
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  131. Hazan EJ, Hornicek FJ, Tomford W, Gebhardt MC, Mankin HJ. The effect of adjuvant chemotherapy on osteoarticular allografts. Clin Orthop Relat Res. 2001 Apr; (385):176-81.
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  132. Sorger JI, Hornicek FJ, Zavatta M, Menzner JP, Gebhardt MC, Tomford WW, Mankin HJ. Allograft fractures revisited. Clin Orthop Relat Res. 2001 Jan; (382):66-74.
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  133. Hornicek FJ, Gebhardt MC, Tomford WW, Sorger JI, Zavatta M, Menzner JP, Mankin HJ. Factors affecting nonunion of the allograft-host junction. Clin Orthop Relat Res. 2001 Jan; (382):87-98.
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  134. Hornicek FJ, Gebhardt MC, Wolfe MW, Kharrazi FD, Takeshita H, Parekh SG, Zurakowski D, Mankin HJ. P-glycoprotein levels predict poor outcome in patients with osteosarcoma. Clin Orthop Relat Res. 2000 Apr; (373):11-7.
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  135. Hornicek FJ, Gebhardt MC, Sorger JI, Mankin HJ. Tumor reconstruction. Orthop Clin North Am. 1999 Oct; 30(4):673-84.
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  136. Rosenthal DI, Hornicek FJ, Wolfe MW, Jennings LC, Gebhardt MC, Mankin HJ. Decreasing length of hospital stay in treatment of osteoid osteoma. Clin Orthop Relat Res. 1999 Apr; (361):186-91.
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  137. Lee FY, Hornicek FJ, Hazan EJ, Kloen P, Wolfe MA, Mankin HJ. Reconstruction of the shoulder joint using an acetabular allograft. A report of two cases. Clin Orthop Relat Res. 1998 Dec; (357):116-21.
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  138. Hornicek FJ, Mnaymneh W, Lackman RD, Exner GU, Malinin TI. Limb salvage with osteoarticular allografts after resection of proximal tibia bone tumors. Clin Orthop Relat Res. 1998 Jul; (352):179-86.
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  139. Rosenthal DI, Hornicek FJ, Wolfe MW, Jennings LC, Gebhardt MC, Mankin HJ. Percutaneous radiofrequency coagulation of osteoid osteoma compared with operative treatment. J Bone Joint Surg Am. 1998 Jun; 80(6):815-21.
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