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Last Name

Elizabeth Hechavarria Yen, M.D.

TitleInstructor in Pediatrics
InstitutionChildren's Hospital Boston
AddressChildrens Hospital
Division of Gastroenterology & Nutrition
300 Longwood Ave
Boston MA 02115

I am a Pediatric Gastroenterologist with special interest in the GI manifestations of cystic fibrosis, and also in the diagnosis and management of eosinophilic esophagitis, with special emphasis on development of biomarkers. Current investigations on the role of early childhood nutrition on survival and outcomes in cystic fibrosis show that attainment of higher weight and height percentiles at a young age predict better outcomes and survival at 18 years of age. I enjoy teaching, am involved in courses at the medical school, and teach residents and fellows in the ambulatory and inpatient settings.

After training in General Pediatrics at the University of Washington, I became a GI fellow at Children's Hospital Boston. During fellowship, I did mucosal immunology research with Dr. Wayne Lencer. Following training, I joined the GI faculty at Children's Hospital Boston, in a Clinician Educator track. I worked closely with the founder of the Eosinophilic Gastrointestinal Diseases Clinic to start this multidisciplinary clinic. I then initiated the reintegration of gastroenterology services in the Cystic Fibrosis Center Clinic at Children's Hospital Boston. I have active collaborations with external CF GI experts to evaluate national CF registry data for nutritional and gastrointestinal disease manifestations and outcomes.

I have been active in teaching of medical students since joining the faculty. My contributions have mainly been as a tutor to groups of 7 to 10 medical and dental students during their first and second years of school. I have also developed lectures for residents and fellows in eosinophilic esophagitis, food allergies, and chronic diarrhea.

 selected publications
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  1. Lexmond WS, Pardo M, Rooney K, Goettel JA, Snapper SB, Yen EH, Dehlink E, Nurko S, Fiebiger E. Elevated levels of leukotriene C4 synthase mRNA distinguish a subpopulation of eosinophilic oesophagitis patients. Clin Exp Allergy. 2013 Aug; 43(8):902-13.
    View in: PubMed
  2. Yen EH, Quinton H, Borowitz D. Better nutritional status in early childhood is associated with improved clinical outcomes and survival in patients with cystic fibrosis. J Pediatr. 2013 Mar; 162(3):530-535.e1.
    View in: PubMed
  3. Lee JJ, Fried AJ, Hait E, Yen EH, Perkins JM, Rubinstein E. Topical inhaled ciclesonide for treatment of eosinophilic esophagitis. J Allergy Clin Immunol. 2012 Oct; 130(4):1011; author reply 1011-2.
    View in: PubMed
  4. Lexmond W, der Mee Jv, Ruiter F, Platzer B, Stary G, Yen EH, Dehlink E, Nurko S, Fiebiger E. Development and validation of a standardized ELISA for the detection of soluble Fc-epsilon-RI in human serum. J Immunol Methods. 2011 Oct 28; 373(1-2):192-9.
    View in: PubMed
  5. Dehlink E, Platzer B, Baker AH, Larosa J, Pardo M, Dwyer P, Yen EH, Sz├ępfalusi Z, Nurko S, Fiebiger E. A soluble form of the high affinity IgE receptor, Fc-epsilon-RI, circulates in human serum. PLoS One. 2011; 6(4):e19098.
    View in: PubMed
  6. Yen EH, Hornick JL, Dehlink E, Dokter M, Baker A, Fiebiger E, Nurko S. Comparative analysis of FceRI expression patterns in patients with eosinophilic and reflux esophagitis. J Pediatr Gastroenterol Nutr. 2010 Nov; 51(5):584-92.
    View in: PubMed
  7. Dehlink E, Baker AH, Yen E, Nurko S, Fiebiger E. Relationships between levels of serum IgE, cell-bound IgE, and IgE-receptors on peripheral blood cells in a pediatric population. PLoS One. 2010; 5(8):e12204.
    View in: PubMed
  8. Tzaban S, Massol RH, Yen E, Hamman W, Frank SR, Lapierre LA, Hansen SH, Goldenring JR, Blumberg RS, Lencer WI. The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity. J Cell Biol. 2009 May 18; 185(4):673-84.
    View in: PubMed
  9. Dehlink E, Yen E, Leichtner AM, Hait EJ, Fiebiger E. First evidence of a possible association between gastric acid suppression during pregnancy and childhood asthma: a population-based register study. Clin Exp Allergy. 2009 Feb; 39(2):246-53.
    View in: PubMed
  10. Dickinson BL, Claypool SM, D'Angelo JA, Aiken ML, Venu N, Yen EH, Wagner JS, Borawski JA, Pierce AT, Hershberg R, Blumberg RS, Lencer WI. Ca2+-dependent calmodulin binding to FcRn affects immunoglobulin G transport in the transcytotic pathway. Mol Biol Cell. 2008 Jan; 19(1):414-23.
    View in: PubMed
  11. Johansen FE, Yen E, Dickinson B, Yoshida M, Claypool S, Blumberg RS, Lencer WI. Biology of Gut Immunoglobulins. Johnson L, Barrett K, Ghishan F, Merchant J, Said H, Wood J. Physiology of the Gastrointestinal Tract. 2006.
  12. Hoffman LR, Yen EH, Kanne JP, Effmann EL, Gibson RL, Van Niel CW. Lipoid pneumonia due to Mexican folk remedies: cultural barriers to diagnosis. Arch Pediatr Adolesc Med. 2005 Nov; 159(11):1043-8.
    View in: PubMed
  13. Yen E, Kothe M, Wagner J, Lencer WI. The Fc-receptor neonatal (FcRn) traffics through the common endosome in mucosal epithelial cells. Oral presentation at the 2005 North American Society for Pediatric Gastroenterology, Hepatology, and Nutrtion, Salt Lake City, UT. 2005.
  14. Cases S, Stone SJ, Zhou P, Yen E, Tow B, Lardizabal KD, Voelker T, Farese RV. Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members. J Biol Chem. 2001 Oct 19; 276(42):38870-6.
    View in: PubMed
  15. Mitty RD, Hechavarria E, Murthi D, Cave DR. Treatment of non-ulcer dyspepsia associated with Helicobacter pylori with omeprazole + clarithromycin: a placebo-controlled, double blind study. Poster presentation at the 1997 Digestive Disease Week Annual Meeting, Washington, D.C. 1997.
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