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Jeannie T. Lee, M.D.,PH.D.

TitleProfessor of Genetics
InstitutionMassachusetts General Hospital
DepartmentGenetics
AddressMassachusetts General Hospital
Simches Research Ctr CPZN# 6624
185 Cambridge St
Boston MA 02114
Phone617/726-5943
Fax617/726-6893

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Yang L, Froberg JE, Lee JT. Long noncoding RNAs: fresh perspectives into the RNA world. Trends Biochem Sci. 2014 Jan; 39(1):35-43.
    View in: PubMed
  2. Payer B, Rosenberg M, Yamaji M, Yabuta Y, Koyanagi-Aoi M, Hayashi K, Yamanaka S, Saitou M, Lee JT. Tsix RNA and the Germline Factor, PRDM14, Link X Reactivation and Stem Cell Reprogramming. Mol Cell. 2013 Dec 26; 52(6):805-18.
    View in: PubMed
  3. Simon MD, Pinter SF, Fang R, Sarma K, Rutenberg-Schoenberg M, Bowman SK, Kesner BA, Maier VK, Kingston RE, Lee JT. High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivation. Nature. 2013 Dec 19; 504(7480):465-9.
    View in: PubMed
  4. Froberg JE, Yang L, Lee JT. Guided by RNAs: X-Inactivation as a Model for lncRNA Function. J Mol Biol. 2013 Oct 9; 425(19):3698-706.
    View in: PubMed
  5. Sun S, Del Rosario BC, Szanto A, Ogawa Y, Jeon Y, Lee JT. Jpx RNA Activates Xist by Evicting CTCF. Cell. 2013 Jun 20; 153(7):1537-51.
    View in: PubMed
  6. Lessing D, Lee JT. X chromosome inactivation and epigenetic responses to cellular reprogramming. Annu Rev Genomics Hum Genet. 2013 Aug 31; 14:85-110.
    View in: PubMed
  7. Sadreyev RI, Yildirim E, Pinter SF, Lee JT. Bimodal quantitative relationships between histone modifications for X-linked and autosomal loci. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6949-54.
    View in: PubMed
  8. Kung JT, Lee JT. RNA in the loop. Dev Cell. 2013 Mar 25; 24(6):565-7.
    View in: PubMed
  9. Lee JT, Bartolomei MS. X-Inactivation, Imprinting, and Long Noncoding RNAs in Health and Disease. Cell. 2013 Mar 14; 152(6):1308-23.
    View in: PubMed
  10. Kung JT, Colognori D, Lee JT. Long Noncoding RNAs: Past, Present, and Future. Genetics. 2013 Mar; 193(3):651-69.
    View in: PubMed
  11. Yildirim E, Kirby JE, Brown DE, Mercier FE, Sadreyev RI, Scadden DT, Lee JT. Xist RNA is a potent suppressor of hematologic cancer in mice. Cell. 2013 Feb 14; 152(4):727-42.
    View in: PubMed
  12. Lee JT. Epigenetic regulation by long noncoding RNAs. Science. 2012 Dec 14; 338(6113):1435-9.
    View in: PubMed
  13. Ougland R, Lando D, Jonson I, Dahl JA, Moen MN, Nordstrand LM, Rognes T, Lee JT, Klungland A, Kouzarides T, Larsen E. ALKBH1 is a Histone H2A Dioxygenase Involved in Neural Differentiation. Stem Cells. 2012 Dec; 30(12):2672-82.
    View in: PubMed
  14. Pinter SF, Sadreyev RI, Yildirim E, Jeon Y, Ohsumi TK, Borowsky M, Lee JT. Spreading of X chromosome inactivation via a hierarchy of defined Polycomb stations. Genome Res. 2012 Oct; 22(10):1864-76.
    View in: PubMed
  15. Erwin JA, Del Rosario B, Payer B, Lee JT. An ex Vivo Model for Imprinting: Mutually Exclusive Binding of Cdx2 and Oct4 as a Switch for Imprinted and Random X-Inactivation. Genetics. 2012 Nov; 192(3):857-68.
    View in: PubMed
  16. Anguera MC, Sadreyev R, Zhang Z, Szanto A, Payer B, Sheridan SD, Kwok S, Haggarty SJ, Sur M, Alvarez J, Gimelbrant A, Mitalipova M, Kirby JE, Lee JT. Molecular signatures of human induced pluripotent stem cells highlight sex differences and cancer genes. Cell Stem Cell. 2012 Jul 6; 11(1):75-90.
    View in: PubMed
  17. Jeon Y, Sarma K, Lee JT. New and Xisting regulatory mechanisms of X chromosome inactivation. Curr Opin Genet Dev. 2012 Apr; 22(2):62-71.
    View in: PubMed
  18. Yildirim E, Sadreyev RI, Pinter SF, Lee JT. X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription. Nat Struct Mol Biol. 2012 Jan; 19(1):56-61.
    View in: PubMed
  19. Lee JT. Gracefully ageing at 50, X-chromosome inactivation becomes a paradigm for RNA and chromatin control. Nat Rev Mol Cell Biol. 2011 Dec; 12(12):815-26.
    View in: PubMed
  20. Anguera MC, Ma W, Clift D, Namekawa S, Kelleher RJ, Lee JT. Tsx produces a long noncoding RNA and has general functions in the germline, stem cells, and brain. PLoS Genet. 2011 Sep; 7(9):e1002248.
    View in: PubMed
  21. Spencer RJ, del Rosario BC, Pinter SF, Lessing D, Sadreyev RI, Lee JT. A boundary element between Tsix and Xist binds the chromatin insulator Ctcf and contributes to initiation of X-chromosome inactivation. Genetics. 2011 Oct; 189(2):441-54.
    View in: PubMed
  22. Jeon Y, Lee JT. YY1 tethers Xist RNA to the inactive X nucleation center. Cell. 2011 Jul 8; 146(1):119-33.
    View in: PubMed
  23. Payer B, Lee JT, Namekawa SH. X-inactivation and X-reactivation: epigenetic hallmarks of mammalian reproduction and pluripotent stem cells. Hum Genet. 2011 Aug; 130(2):265-80.
    View in: PubMed
  24. Kim DH, Jeon Y, Anguera MC, Lee JT. X-chromosome epigenetic reprogramming in pluripotent stem cells via noncoding genes. Semin Cell Dev Biol. 2011 Jun; 22(4):336-42.
    View in: PubMed
  25. Namekawa SH, Lee JT. Detection of nascent RNA, single-copy DNA and protein localization by immunoFISH in mouse germ cells and preimplantation embryos. Nat Protoc. 2011 Mar; 6(3):270-84.
    View in: PubMed
  26. Zhao J, Ohsumi TK, Kung JT, Ogawa Y, Grau DJ, Sarma K, Song JJ, Kingston RE, Borowsky M, Lee JT. Genome-wide identification of polycomb-associated RNAs by RIP-seq. Mol Cell. 2010 Dec 22; 40(6):939-53.
    View in: PubMed
  27. Sarma K, Levasseur P, Aristarkhov A, Lee JT. Locked nucleic acids (LNAs) reveal sequence requirements and kinetics of Xist RNA localization to the X chromosome. Proc Natl Acad Sci U S A. 2010 Dec 21; 107(51):22196-201.
    View in: PubMed
  28. Nordstrand LM, Svärd J, Larsen E, Nilsen A, Ougland R, Furu K, Lien GF, Rognes T, Namekawa SH, Lee JT, Klungland A. Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects. PLoS One. 2010; 5(11):e13827.
    View in: PubMed
  29. Tian D, Sun S, Lee JT. The long noncoding RNA, Jpx, is a molecular switch for X chromosome inactivation. Cell. 2010 Oct 29; 143(3):390-403.
    View in: PubMed
  30. Ahn JY, Lee JT. Retinoic acid accelerates downregulation of the Xist repressor, Oct4, and increases the likelihood of Xist activation when Tsix is deficient. BMC Dev Biol. 2010; 10:90.
    View in: PubMed
  31. Sun S, Fukue Y, Nolen L, Sadreyev R, Lee JT. Characterization of Xpr (Xpct) reveals instability but no effects on X-chromosome pairing or Xist expression. Transcription. 2010 Jul-Aug; 1(1):46-56.
    View in: PubMed
  32. Lengner CJ, Gimelbrant AA, Erwin JA, Cheng AW, Guenther MG, Welstead GG, Alagappan R, Frampton GM, Xu P, Muffat J, Santagata S, Powers D, Barrett CB, Young RA, Lee JT, Jaenisch R, Mitalipova M. Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations. Cell. 2010 May 28; 141(5):872-83.
    View in: PubMed
  33. Namekawa SH, Payer B, Huynh KD, Jaenisch R, Lee JT. Two-step imprinted X inactivation: repeat versus genic silencing in the mouse. Mol Cell Biol. 2010 Jul; 30(13):3187-205.
    View in: PubMed
  34. Paro R, Lee JT. Extending the frontiers of epigenetic regulation. Curr Opin Genet Dev. 2010 Apr; 20(2):107-9.
    View in: PubMed
  35. Lee JT. The X as model for RNA's niche in epigenomic regulation. Cold Spring Harb Perspect Biol. 2010 Sep; 2(9):a003749.
    View in: PubMed
  36. Erwin JA, Lee JT. Characterization of X-chromosome inactivation status in human pluripotent stem cells. Curr Protoc Stem Cell Biol. 2010 Feb; Chapter 1:Unit 1B.6.
    View in: PubMed
  37. Zhou D, Conrad C, Xia F, Park JS, Payer B, Yin Y, Lauwers GY, Thasler W, Lee JT, Avruch J, Bardeesy N. Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell. 2009 Nov 6; 16(5):425-38.
    View in: PubMed
  38. Lee JT. Lessons from X-chromosome inactivation: long ncRNA as guides and tethers to the epigenome. Genes Dev. 2009 Aug 15; 23(16):1831-42.
    View in: PubMed
  39. Donohoe ME, Silva SS, Pinter SF, Xu N, Lee JT. The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting. Nature. 2009 Jul 2; 460(7251):128-32.
    View in: PubMed
  40. Namekawa SH, Lee JT. XY and ZW: is meiotic sex chromosome inactivation the rule in evolution? PLoS Genet. 2009 May; 5(5):e1000493.
    View in: PubMed
  41. Zhang LF, Ogawa Y, Ahn JY, Namekawa SH, Silva SS, Lee JT. Telomeric RNAs mark sex chromosomes in stem cells. Genetics. 2009 Jul; 182(3):685-98.
    View in: PubMed
  42. Anguera MC, Liu M, Avruch J, Lee JT. Characterization of two Mst1-deficient mouse models. Dev Dyn. 2008 Nov; 237(11):3424-34.
    View in: PubMed
  43. Zhao J, Sun BK, Erwin JA, Song JJ, Lee JT. Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome. Science. 2008 Oct 31; 322(5902):750-6.
    View in: PubMed
  44. Lee JT. Jeannie T. Lee. Curr Biol. 2008 Oct 28; 18(20):R940-1.
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  45. Lindroth AM, Park YJ, McLean CM, Dokshin GA, Persson JM, Herman H, Pasini D, Miró X, Donohoe ME, Lee JT, Helin K, Soloway PD. Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus. PLoS Genet. 2008; 4(8):e1000145.
    View in: PubMed
  46. Ogawa Y, Sun BK, Lee JT. Intersection of the RNA interference and X-inactivation pathways. Science. 2008 Jun 6; 320(5881):1336-41.
    View in: PubMed
  47. Erwin JA, Lee JT. New twists in X-chromosome inactivation. Curr Opin Cell Biol. 2008 Jun; 20(3):349-55.
    View in: PubMed
  48. Tsai CL, Rowntree RK, Cohen DE, Lee JT. Higher order chromatin structure at the X-inactivation center via looping DNA. Dev Biol. 2008 Jul 15; 319(2):416-25.
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  49. Silva SS, Rowntree RK, Mekhoubad S, Lee JT. X-chromosome inactivation and epigenetic fluidity in human embryonic stem cells. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4820-5.
    View in: PubMed
  50. Payer B, Lee JT. X chromosome dosage compensation: how mammals keep the balance. Annu Rev Genet. 2008; 42:733-72.
    View in: PubMed
  51. Lin H, Gupta V, Vermilyea MD, Falciani F, Lee JT, O'Neill LP, Turner BM. Dosage compensation in the mouse balances up-regulation and silencing of X-linked genes. PLoS Biol. 2007 Dec; 5(12):e326.
    View in: PubMed
  52. Xu N, Donohoe ME, Silva SS, Lee JT. Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein. Nat Genet. 2007 Nov; 39(11):1390-6.
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  53. Namekawa SH, VandeBerg JL, McCarrey JR, Lee JT. Sex chromosome silencing in the marsupial male germ line. Proc Natl Acad Sci U S A. 2007 Jun 5; 104(23):9730-5.
    View in: PubMed
  54. Zhang LF, Huynh KD, Lee JT. Perinucleolar targeting of the inactive X during S phase: evidence for a role in the maintenance of silencing. Cell. 2007 May 18; 129(4):693-706.
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  55. Mikkelsen TS, Wakefield MJ, Aken B, Amemiya CT, Chang JL, Duke S, Garber M, Gentles AJ, Goodstadt L, Heger A, Jurka J, Kamal M, Mauceli E, Searle SM, Sharpe T, Baker ML, Batzer MA, Benos PV, Belov K, Clamp M, Cook A, Cuff J, Das R, Davidow L, Deakin JE, Fazzari MJ, Glass JL, Grabherr M, Greally JM, Gu W, Hore TA, Huttley GA, Kleber M, Jirtle RL, Koina E, Lee JT, Mahony S, Marra MA, Miller RD, Nicholls RD, Oda M, Papenfuss AT, Parra ZE, Pollock DD, Ray DA, Schein JE, Speed TP, Thompson K, VandeBerg JL, Wade CM, Walker JA, Waters PD, Webber C, Weidman JR, Xie X, Zody MC. Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences. Nature. 2007 May 10; 447(7141):167-77.
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  56. Kim S, Namekawa SH, Niswander LM, Ward JO, Lee JT, Bardwell VJ, Zarkower D. A mammal-specific Doublesex homolog associates with male sex chromatin and is required for male meiosis. PLoS Genet. 2007 Apr 20; 3(4):e62.
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  57. Davidow LS, Breen M, Duke SE, Samollow PB, McCarrey JR, Lee JT. The search for a marsupial XIC reveals a break with vertebrate synteny. Chromosome Res. 2007; 15(2):137-46.
    View in: PubMed
  58. Donohoe ME, Zhang LF, Xu N, Shi Y, Lee JT. Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch. Mol Cell. 2007 Jan 12; 25(1):43-56.
    View in: PubMed
  59. Cohen DE, Davidow LS, Erwin JA, Xu N, Warshawsky D, Lee JT. The DXPas34 repeat regulates random and imprinted X inactivation. Dev Cell. 2007 Jan; 12(1):57-71.
    View in: PubMed
  60. Lewis A, Green K, Dawson C, Redrup L, Huynh KD, Lee JT, Hemberger M, Reik W. Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo. Development. 2006 Nov; 133(21):4203-10.
    View in: PubMed
  61. Rowntree RK, Lee JT. Mapping of DNA replication origins to noncoding genes of the X-inactivation center. Mol Cell Biol. 2006 May; 26(10):3707-17.
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  62. Namekawa SH, Park PJ, Zhang LF, Shima JE, McCarrey JR, Griswold MD, Lee JT. Postmeiotic sex chromatin in the male germline of mice. Curr Biol. 2006 Apr 4; 16(7):660-7.
    View in: PubMed
  63. Sun BK, Deaton AM, Lee JT. A transient heterochromatic state in Xist preempts X inactivation choice without RNA stabilization. Mol Cell. 2006 Mar 3; 21(5):617-28.
    View in: PubMed
  64. Boumil RM, Ogawa Y, Sun BK, Huynh KD, Lee JT. Differential methylation of Xite and CTCF sites in Tsix mirrors the pattern of X-inactivation choice in mice. Mol Cell Biol. 2006 Mar; 26(6):2109-17.
    View in: PubMed
  65. Xu N, Tsai CL, Lee JT. Transient homologous chromosome pairing marks the onset of X inactivation. Science. 2006 Feb 24; 311(5764):1149-52.
    View in: PubMed
  66. Lee JT. Regulation of X-chromosome counting by Tsix and Xite sequences. Science. 2005 Jul 29; 309(5735):768-71.
    View in: PubMed
  67. Huynh KD, Lee JT. X-chromosome inactivation: a hypothesis linking ontogeny and phylogeny. Nat Rev Genet. 2005 May; 6(5):410-8.
    View in: PubMed
  68. Lee JT. Sex chromosome inactivation: the importance of pairing. Curr Biol. 2005 Apr 12; 15(7):R249-52.
    View in: PubMed
  69. Stavropoulos N, Rowntree RK, Lee JT. Identification of developmentally specific enhancers for Tsix in the regulation of X chromosome inactivation. Mol Cell Biol. 2005 Apr; 25(7):2757-69.
    View in: PubMed
  70. Shibata S, Lee JT. Tsix transcription- versus RNA-based mechanisms in Xist repression and epigenetic choice. Curr Biol. 2004 Oct 5; 14(19):1747-54.
    View in: PubMed
  71. Huynh KD, Lee JT. Inheritance of a pre-inactivated paternal X chromosome in early mouse embryos. Nature. 2003 Dec 18; 426(6968):857-62.
    View in: PubMed
  72. Lee JT. X-chromosome inactivation: a multi-disciplinary approach. Semin Cell Dev Biol. 2003 Dec; 14(6):311-2.
    View in: PubMed
  73. Lee JT. Functional intergenic transcription: a case study of the X-inactivation centre. Philos Trans R Soc Lond B Biol Sci. 2003 Aug 29; 358(1436):1417-23; discussion 1423.
    View in: PubMed
  74. O'Neill LP, Randall TE, Lavender J, Spotswood HT, Lee JT, Turner BM. X-linked genes in female embryonic stem cells carry an epigenetic mark prior to the onset of X inactivation. Hum Mol Genet. 2003 Aug 1; 12(15):1783-90.
    View in: PubMed
  75. Lee JT. Molecular biology: Complicity of gene and pseudogene. Nature. 2003 May 1; 423(6935):26-8.
    View in: PubMed
  76. Lee JT. Molecular links between X-inactivation and autosomal imprinting: X-inactivation as a driving force for the evolution of imprinting? Curr Biol. 2003 Mar 18; 13(6):R242-54.
    View in: PubMed
  77. Ogawa Y, Lee JT. Xite, X-inactivation intergenic transcription elements that regulate the probability of choice. Mol Cell. 2003 Mar; 11(3):731-43.
    View in: PubMed
  78. Shibata S, Lee JT. Characterization and quantitation of differential Tsix transcripts: implications for Tsix function. Hum Mol Genet. 2003 Jan 15; 12(2):125-36.
    View in: PubMed
  79. Lee JT. Homozygous Tsix mutant mice reveal a sex-ratio distortion and revert to random X-inactivation. Nat Genet. 2002 Sep; 32(1):195-200.
    View in: PubMed
  80. Cohen DE, Lee JT. X-chromosome inactivation and the search for chromosome-wide silencers. Curr Opin Genet Dev. 2002 Apr; 12(2):219-24.
    View in: PubMed
  81. Lee JT. Is X-chromosome inactivation a homology effect? Adv Genet. 2002; 46:25-48.
    View in: PubMed
  82. Chao W, Huynh KD, Spencer RJ, Davidow LS, Lee JT. CTCF, a candidate trans-acting factor for X-inactivation choice. Science. 2002 Jan 11; 295(5553):345-7.
    View in: PubMed
  83. Lee JT. Disruption of imprinted X inactivation by parent-of-origin effects at Tsix. Cell. 2000 Sep 29; 103(1):17-27.
    View in: PubMed
  84. Lee JT, Lu N. Targeted mutagenesis of Tsix leads to nonrandom X inactivation. Cell. 1999 Oct 1; 99(1):47-57.
    View in: PubMed
  85. Lee JT, Davidow LS, Warshawsky D. Tsix, a gene antisense to Xist at the X-inactivation centre. Nat Genet. 1999 Apr; 21(4):400-4.
    View in: PubMed
  86. Lee JT, Lu N, Han Y. Genetic analysis of the mouse X inactivation center defines an 80-kb multifunction domain. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3836-41.
    View in: PubMed
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