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James Bradley Kobler, PH.D.

TitleAssistant Professor of Surgery
InstitutionMassachusetts General Hospital
DepartmentSurgery
AddressMassachusetts General Hospital
Thier Bldg - 620
55 Fruit St
Boston MA 02114
Phone617/573-3830
Fax617/720-4408

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Friedman AD, Kobler JB, Landau-Zemer T, Barbu AM, Burns JA. High-force simulated intubation fails to dislocate cricoarytenoid joint in ex vivo human larynges. Ann Otol Rhinol Laryngol. 2012 Nov; 121(11):746-53.
    View in: PubMed
  2. Chang EW, Kobler JB, Yun SH. Subnanometer optical coherence tomographic vibrography. Opt Lett. 2012 Sep 1; 37(17):3678-80.
    View in: PubMed
  3. Heaton JT, Kobler JB, Ottensmeyer MP, Lopez-Guerra G, Karajanagi SS, Burns JA, Zeitels SM. Modification and testing of a pneumatic dispensing device for controlled delivery of injectable materials. Laryngoscope. 2012 Sep; 122(9):2023-8.
    View in: PubMed
  4. Koo HJ, Burns JA, Kobler JB, Heaton JT, Zeitels SM. Novel device for tissue cooling during endoscopic laryngeal laser surgery: thermal damage study in an ex vivo calf model. Ann Otol Rhinol Laryngol. 2012 Jul; 121(7):485-9.
    View in: PubMed
  5. Hoy CL, Everett WN, Yildirim M, Kobler J, Zeitels SM, Ben-Yakar A. Towards endoscopic ultrafast laser microsurgery of vocal folds. J Biomed Opt. 2012 Mar; 17(3):038002.
    View in: PubMed
  6. Chang EW, Kobler JB, Yun SH. Triggered optical coherence tomography for capturing rapid periodic motion. Sci Rep. 2011; 1:48.
    View in: PubMed
  7. Burns JA, Lopez-Guerra G, Kobler JB, Faquin W, LeClair M, Zeitels SM. Pulsed potassium-titanyl-phosphate laser photoangiolytic treatment of mucosal squamous cell carcinoma in the hamster cheek pouch. Laryngoscope. 2011 May; 121(5):942-6.
    View in: PubMed
  8. Karajanagi SS, Lopez-Guerra G, Park H, Kobler JB, Galindo M, Aanestad J, Mehta DD, Kumai Y, Giordano N, d'Almeida A, Heaton JT, Langer R, Herrera VL, Faquin W, Hillman RE, Zeitels SM. Assessment of canine vocal fold function after injection of a new biomaterial designed to treat phonatory mucosal scarring. Ann Otol Rhinol Laryngol. 2011 Mar; 120(3):175-84.
    View in: PubMed
  9. Burns JA, Lopez-Guerra G, Heaton JT, Kobler JB, Kraas J, Zeitels SM. Cooling the "oven": a temperature study of air and glottal tissue during laser surgery in an ex vivo calf larynx model. Ann Otol Rhinol Laryngol. 2010 Oct; 119(10):684-9.
    View in: PubMed
  10. Kobler JB, Chang EW, Zeitels SM, Yun SH. Dynamic imaging of vocal fold oscillation with four-dimensional optical coherence tomography. Laryngoscope. 2010 Jul; 120(7):1354-62.
    View in: PubMed
  11. Kumai Y, Kobler JB, Herrera VL, Zeitels SM. Perspectives on adipose-derived stem/stromal cells as potential treatment for scarred vocal folds: opportunity and challenges. Curr Stem Cell Res Ther. 2010 Jun; 5(2):175-81.
    View in: PubMed
  12. Park H, Yip MC, Chertok B, Kost J, Kobler JB, Langer R, Zeitels SM. Indirect low-intensity ultrasonic stimulation for tissue engineering. J Tissue Eng. 2010; 2010:973530.
    View in: PubMed
  13. Luo Y, Kobler JB, Heaton JT, Jia X, Zeitels SM, Langer R. Injectable hyaluronic acid-dextran hydrogels and effects of implantation in ferret vocal fold. J Biomed Mater Res B Appl Biomater. 2010 May; 93(2):386-93.
    View in: PubMed
  14. Kumai Y, Kobler JB, Park H, Galindo M, Herrera VL, Zeitels SM. Modulation of vocal fold scar fibroblasts by adipose-derived stem/stromal cells. Laryngoscope. 2010 Feb; 120(2):330-7.
    View in: PubMed
  15. Park H, Karajanagi S, Wolak K, Aanestad J, Daheron L, Kobler JB, Lopez-Guerra G, Heaton JT, Langer RS, Zeitels SM. Three-dimensional hydrogel model using adipose-derived stem cells for vocal fold augmentation. Tissue Eng Part A. 2010 Feb; 16(2):535-43.
    View in: PubMed
  16. Herrera VL, Viereck JC, Lopez-Guerra G, Kumai Y, Kobler J, Karajanagi S, Park H, Hillman R, Zeitels SM. 11.7 Tesla magnetic resonance microimaging of laryngeal tissue architecture. Laryngoscope. 2009 Nov; 119(11):2187-94.
    View in: PubMed
  17. Burns JA, Kim KH, Kobler JB, deBoer JF, Lopez-Guerra G, Zeitels SM. Real-time tracking of vocal fold injections with optical coherence tomography. Laryngoscope. 2009 Nov; 119(11):2182-6.
    View in: PubMed
  18. Kumai Y, Kobler JB, Park H, Lopez-Guerra G, Karajanagi S, Herrera VL, Zeitels SM. Crosstalk between adipose-derived stem/stromal cells and vocal fold fibroblasts in vitro. Laryngoscope. 2009 Apr; 119(4):799-805.
    View in: PubMed
  19. Walsh CJ, Heaton JT, Kobler JB, Szabo TL, Zeitels SM. Imaging of the calf vocal fold with high-frequency ultrasound. Laryngoscope. 2008 Oct; 118(10):1894-9.
    View in: PubMed
  20. Park H, Williams R, Goldman N, Choe H, Kobler J, Lopez-Guerra G, Heaton JT, Langer R, Zeitels SM. Comparison of effects of 2 harvesting methods on fat autograft. Laryngoscope. 2008 Aug; 118(8):1493-9.
    View in: PubMed
  21. Burns JA, Kobler JB, Heaton JT, Anderson RR, Zeitels SM. Predicting clinical efficacy of photoangiolytic and cutting/ablating lasers using the chick chorioallantoic membrane model: implications for endoscopic voice surgery. Laryngoscope. 2008 Jun; 118(6):1109-24.
    View in: PubMed
  22. Chau Y, Luo Y, Cheung AC, Nagai Y, Zhang S, Kobler JB, Zeitels SM, Langer R. Incorporation of a matrix metalloproteinase-sensitive substrate into self-assembling peptides - a model for biofunctional scaffolds. Biomaterials. 2008 Apr; 29(11):1713-9.
    View in: PubMed
  23. Broadhurst MS, Kobler JB, Burns JA, Anderson RR, Zeitels SM. Chick chorioallantoic membrane as a model for simulating human true vocal folds. Ann Otol Rhinol Laryngol. 2007 Dec; 116(12):917-21.
    View in: PubMed
  24. Burns JA, Kobler JB, Heaton JT, Lopez-Guerra G, Anderson RR, Zeitels SM. Thermal damage during thulium laser dissection of laryngeal soft tissue is reduced with air cooling: ex vivo calf model study. Ann Otol Rhinol Laryngol. 2007 Nov; 116(11):853-7.
    View in: PubMed
  25. Broadhurst MS, Akst LM, Burns JA, Kobler JB, Heaton JT, Anderson RR, Zeitels SM. Effects of 532 nm pulsed-KTP laser parameters on vessel ablation in the avian chorioallantoic membrane: implications for vocal fold mucosa. Laryngoscope. 2007 Feb; 117(2):220-5.
    View in: PubMed
  26. Luo Y, Kobler JB, Zeitels SM, Langer R. Effects of growth factors on extracellular matrix production by vocal fold fibroblasts in 3-dimensional culture. Tissue Eng. 2006 Dec; 12(12):3365-74.
    View in: PubMed
  27. Jia X, Yeo Y, Clifton RJ, Jiao T, Kohane DS, Kobler JB, Zeitels SM, Langer R. Hyaluronic acid-based microgels and microgel networks for vocal fold regeneration. Biomacromolecules. 2006 Dec; 7(12):3336-44.
    View in: PubMed
  28. Kobler JB, Rosen DI, Burns JA, Akst LM, Broadhurst MS, Zeitels SM, Hillman RE. Comparison of a flexible laryngoscope with calibrated sizing function to intraoperative measurements. Ann Otol Rhinol Laryngol. 2006 Oct; 115(10):733-40.
    View in: PubMed
  29. Goodyer E, Hemmerich S, Müller F, Kobler JB, Hess M. The shear modulus of the human vocal fold, preliminary results from 20 larynxes. Eur Arch Otorhinolaryngol. 2007 Jan; 264(1):45-50.
    View in: PubMed
  30. Zeitels SM, Kobler JB, Heaton JT, Faquin W. Carbon dioxide laser fiber for laryngeal cancer surgery. Ann Otol Rhinol Laryngol. 2006 Jul; 115(7):535-41.
    View in: PubMed
  31. Klein AM, Pierce MC, Zeitels SM, Anderson RR, Kobler JB, Shishkov M, de Boer JF. Imaging the human vocal folds in vivo with optical coherence tomography: a preliminary experience. Ann Otol Rhinol Laryngol. 2006 Apr; 115(4):277-84.
    View in: PubMed
  32. Hahn MS, Kobler JB, Zeitels SM, Langer R. Quantitative and comparative studies of the vocal fold extracellular matrix II: collagen. Ann Otol Rhinol Laryngol. 2006 Mar; 115(3):225-32.
    View in: PubMed
  33. Hahn MS, Kobler JB, Starcher BC, Zeitels SM, Langer R. Quantitative and comparative studies of the vocal fold extracellular matrix. I: Elastic fibers and hyaluronic acid. Ann Otol Rhinol Laryngol. 2006 Feb; 115(2):156-64.
    View in: PubMed
  34. Hess MM, Mueller F, Kobler JB, Zeitels SM, Goodyer E. Measurements of vocal fold elasticity using the linear skin rheometer. Folia Phoniatr Logop. 2006; 58(3):207-16.
    View in: PubMed
  35. Burns JA, Zeitels SM, Anderson RR, Kobler JB, Pierce MC, de Boer JF. Imaging the mucosa of the human vocal fold with optical coherence tomography. Ann Otol Rhinol Laryngol. 2005 Sep; 114(9):671-6.
    View in: PubMed
  36. Heaton JT, Kobler JB, Hillman RE, Zeitels SM. A new instrument for intraoperative assessment of individual vocal folds. Laryngoscope. 2005 Jul; 115(7):1223-9.
    View in: PubMed
  37. Gunter HE, Howe RD, Zeitels SM, Kobler JB, Hillman RE. Measurement of vocal fold collision forces during phonation: methods and preliminary data. J Speech Lang Hear Res. 2005 Jun; 48(3):567-76.
    View in: PubMed
  38. Hahn MS, Kobler JB, Zeitels SM, Langer R. Midmembranous vocal fold lamina propria proteoglycans across selected species. Ann Otol Rhinol Laryngol. 2005 Jun; 114(6):451-62.
    View in: PubMed
  39. Holzrichter JF, Ng LC, Burke GJ, Champagne NJ, Kallman JS, Sharpe RM, Kobler JB, Hillman RE, Rosowski JJ. Measurements of glottal structure dynamics. J Acoust Soc Am. 2005 Mar; 117(3 Pt 1):1373-85.
    View in: PubMed
  40. Heaton JT, Kobler JB. Use of muscle fibrillation for tracking nerve regeneration. Muscle Nerve. 2005 Feb; 31(2):235-41.
    View in: PubMed
  41. Raskar R, Tan KH, Feris RS, Turk M, Kobler J, Yu J. Harnessing real-world depth edges with multiflash imaging. IEEE Comput Graph Appl. 2005 Jan-Feb; 25(1):32-8.
    View in: PubMed
  42. Dailey SH, Kobler JB, Hillman RE, Tangrom K, Thananart E, Mauri M, Zeitels SM. Endoscopic measurement of vocal fold movement during adduction and abduction. Laryngoscope. 2005 Jan; 115(1):178-83.
    View in: PubMed
  43. Burns JA, Kobler JB, Zeitels SM. Microstereo-laryngoscopic lipoinjection: practical considerations. Laryngoscope. 2004 Oct; 114(10):1864-7.
    View in: PubMed
  44. Heaton JT, Goldstein EA, Kobler JB, Zeitels SM, Randolph GW, Walsh MJ, Gooey JE, Hillman RE. Surface electromyographic activity in total laryngectomy patients following laryngeal nerve transfer to neck strap muscles. Ann Otol Rhinol Laryngol. 2004 Sep; 113(9):754-64.
    View in: PubMed
  45. Randolph GW, Kobler JB, Wilkins J. Recurrent laryngeal nerve identification and assessment during thyroid surgery: laryngeal palpation. World J Surg. 2004 Aug; 28(8):755-60.
    View in: PubMed
  46. Dailey SH, Kobler JB, Zeitels SM. A laryngeal dissection station: educational paradigms in phonosurgery. Laryngoscope. 2004 May; 114(5):878-82.
    View in: PubMed
  47. Goldstein EA, Heaton JT, Kobler JB, Stanley GB, Hillman RE. Design and implementation of a hands-free electrolarynx device controlled by neck strap muscle electromyographic activity. IEEE Trans Biomed Eng. 2004 Feb; 51(2):325-32.
    View in: PubMed
  48. Jia X, Burdick JA, Kobler J, Clifton RJ, Rosowski JJ, Zeitels SM, Langer R. . Synthesis and Characterization of in Situ Crosslinkable Hyaluronic Acid-Based Hydrogels with Potential Application for Vocal Fold Regeneration. Macromolecules. 2004; 37:3239-3248.
  49. K Tan, J Kobler, P H. Dietz, R Raskar, R S Feris. : Shape-Enhanced Surgical Visualizations and Medical Illustrations with Multi-flash Imaging. MICCAI. MICCAI. 2004; 2:438-445.
  50. Bunaprasert T, Hadlock T, Marler J, Kobler J, Cowan D, Faquin W, Varvares M. Tissue engineered muscle implantation for tongue reconstruction: a preliminary report. Laryngoscope. 2003 Oct; 113(10):1792-7.
    View in: PubMed
  51. Meltzner GS, Kobler JB, Hillman RE. Measuring the neck frequency response function of laryngectomy patients: implications for the design of electrolarynx devices. J Acoust Soc Am. 2003 Aug; 114(2):1035-47.
    View in: PubMed
  52. Schade G, Hess M, Müller F, Kirchhoff T, Ludwigs M, Hillman R, Kobler J. [Physical and technical elements of short-interval, color-filtered double strobe flash-stroboscopy]. HNO. 2002 Dec; 50(12):1079-83.
    View in: PubMed
  53. Hess MM, Ludwigs M, Kobler JB, Schade G. Imaging of the larynx--extending the use of stroboscopy-related techniques. Logoped Phoniatr Vocol. 2002; 27(2):50-8.
    View in: PubMed
  54. Merscher S, Funke B, Epstein JA, Heyer J, Puech A, Lu MM, Xavier RJ, Demay MB, Russell RG, Factor S, Tokooya K, Jore BS, Lopez M, Pandita RK, Lia M, Carrion D, Xu H, Schorle H, Kobler JB, Scambler P, Wynshaw-Boris A, Skoultchi AI, Morrow BE, Kucherlapati R. TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome. Cell. 2001 Feb 23; 104(4):619-29.
    View in: PubMed
  55. Heaton JT, Kobler JB, Goldstein EA, McMahon TA, Barry DT, Hillman RE. Recurrent laryngeal nerve transposition in guinea pigs. Ann Otol Rhinol Laryngol. 2000 Oct; 109(10 Pt 1):972-80.
    View in: PubMed
  56. Vaid J, Kobler JB. Laughing matters: toward a structural and neural account. Brain Cogn. 2000 Feb; 42(1):139-41.
    View in: PubMed
  57. Wiener-Vacher SR, Guinan JJ, Kobler JB, Norris BE. Motoneuron axon distribution in the cat stapedius muscle. Hear Res. 1999 Jul; 133(1-2):139-48.
    View in: PubMed
  58. Kobler JB, Hillman RE, Zeitels SM, Kuo J. Assessment of vocal function using simultaneous aerodynamic and calibrated videostroboscopic measures. Ann Otol Rhinol Laryngol. 1998 Jun; 107(6):477-85.
    View in: PubMed
  59. Kobler JB, Datta S, Goyal RK, Benecchi EJ. Innervation of the larynx, pharynx, and upper esophageal sphincter of the rat. J Comp Neurol. 1994 Nov 1; 349(1):129-47.
    View in: PubMed
  60. Sillman JS, Levine RA, Kobler JB. Laser Doppler measurements of intratemporal facial nerve blood flow. Am J Otol. 1994 May; 15(3):327-34.
    View in: PubMed
  61. Kobler JB, Guinan JJ, Vacher SR, Norris BE. Acoustic reflex frequency selectivity in single stapedius motoneurons of the cat. J Neurophysiol. 1992 Sep; 68(3):807-17.
    View in: PubMed
  62. Vacher SR, Guinan JJ, Kobler JB. Intracellularly labeled stapedius-motoneuron cell bodies in the cat are spatially organized according to their physiologic responses. J Comp Neurol. 1989 Nov 15; 289(3):401-15.
    View in: PubMed
  63. Casseday JH, Kobler JB, Isbey SF, Covey E. Central acoustic tract in an echolocating bat: an extralemniscal auditory pathway to the thalamus. J Comp Neurol. 1989 Sep 8; 287(2):247-59.
    View in: PubMed
  64. Kobler JB, Vacher SR, Guinan JJ. The recruitment order of stapedius motoneurons in the acoustic reflex varies with sound laterality. Brain Res. 1987 Nov 10; 425(2):372-5.
    View in: PubMed
  65. Covey E, Hall WC, Kobler JB. Subcortical connections of the superior colliculus in the mustache bat, Pteronotus parnellii. J Comp Neurol. 1987 Sep 8; 263(2):179-97.
    View in: PubMed
  66. Kobler JB, Isbey SF, Casseday JH. Auditory pathways to the frontal cortex of the mustache bat, Pteronotus parnellii. Science. 1987 May 15; 236(4803):824-6.
    View in: PubMed
  67. Kobler JB, Wilson BS, Henson OW, Bishop AL. Echo intensity compensation by echolocating bats. Hear Res. 1985; 20(2):99-108.
    View in: PubMed
  68. Henson OW, Pollak GD, Kobler JB, Henson MM, Goldman LJ. Cochlear microphonic potentials elicited by biosonar signals in flying bats, Pteronotus p. parnellii. Hear Res. 1982 Jul; 7(2):127-47.
    View in: PubMed
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