Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

Constance Cepko, Ph.D.

TitleBullard Professor of Genetics and Neuroscience
InstitutionHarvard Medical School
DepartmentGenetics
AddressHarvard Medical School
Genetics NRB Room 360
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/432-7618
Fax617/432-7595
Other Positions
TitleProfessor of Ophthalmology
InstitutionMassachusetts Eye and Ear Infirmary
DepartmentOphthalmology


 Mentoring 
 current student opportunities
Available: 11/01/13, Expires: 08/31/15

Our laboratory is studying the development and disease of the retina. There are three areas of investigation. One concerns how the diversity of over 60 types of retinal neurons is generated during development. Another project is aimed towards understanding how these retinal neurons connect to form functional circuits. A third area concerns retinal disease, primarily retinitis pigmentosa, an inherited form of blindness. In all of these areas, we utilize molecular, genetic, and cell biological approaches. Several projects involve gene transfer using viral vectors, and require some innovation of the current viral vectors. Projects for medical students can be arranged in each of these areas, and will depend upon the interest and background of the student.

 completed student projects
Deciphering the Role of Alternative Splicing Factors Cugbp2 and Sfrs6 in Retinal Development
Summer, 06/11/07 - 08/17/07

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Mizeracka K, Trimarchi JM, Stadler MB, Cepko CL. Analysis of gene expression in wild-type and Notch1 mutant retinal cells by single cell profiling. Dev Dyn. 2013 Oct; 242(10):1147-59.
    View in: PubMed
  2. Tang JC, Szikra T, Kozorovitskiy Y, Teixiera M, Sabatini BL, Roska B, Cepko CL. A nanobody-based system using fluorescent proteins as scaffolds for cell-specific gene manipulation. Cell. 2013 Aug 15; 154(4):928-39.
    View in: PubMed
  3. Jiang H, Wang L, Beier KT, Cepko CL, Fekete DM, Brigande JV. Lineage analysis of the late otocyst stage mouse inner ear by transuterine microinjection of a retroviral vector encoding alkaline phosphatase and an oligonucleotide library. PLoS One. 2013; 8(7):e69314.
    View in: PubMed
  4. Emerson MM, Surzenko N, Goetz JJ, Trimarchi J, Cepko CL. Otx2 and onecut1 promote the fates of cone photoreceptors and horizontal cells and repress rod photoreceptors. Dev Cell. 2013 Jul 15; 26(1):59-72.
    View in: PubMed
  5. Mizeracka K, Demaso CR, Cepko CL. Notch1 is required in newly postmitotic cells to inhibit the rod photoreceptor fate. Development. 2013 Aug; 140(15):3188-97.
    View in: PubMed
  6. Beier KT, Saunders AB, Oldenburg IA, Sabatini BL, Cepko CL. Vesicular stomatitis virus with the rabies virus glycoprotein directs retrograde transsynaptic transport among neurons in vivo. Front Neural Circuits. 2013; 7:11.
    View in: PubMed
  7. Whited JL, Tsai SL, Beier KT, White JN, Piekarski N, Hanken J, Cepko CL, Tabin CJ. Pseudotyped retroviruses for infecting axolotl in vivo and in vitro. Development. 2013 Mar; 140(5):1137-46.
    View in: PubMed
  8. Beier KT, Borghuis BG, El-Danaf RN, Huberman AD, Demb JB, Cepko CL. Transsynaptic tracing with vesicular stomatitis virus reveals novel retinal circuitry. J Neurosci. 2013 Jan 2; 33(1):35-51.
    View in: PubMed
  9. Beier K, Cepko C. Viral tracing of genetically defined neural circuitry. J Vis Exp. 2012; (68).
    View in: PubMed
  10. Cepko CL. Emerging gene therapies for retinal degenerations. J Neurosci. 2012 May 9; 32(19):6415-20.
    View in: PubMed
  11. Roesch K, Stadler MB, Cepko CL. Gene expression changes within Müller glial cells in retinitis pigmentosa. Mol Vis. 2012; 18:1197-214.
    View in: PubMed
  12. Hafler BP, Surzenko N, Beier KT, Punzo C, Trimarchi JM, Kong JH, Cepko CL. Transcription factor Olig2 defines subpopulations of retinal progenitor cells biased toward specific cell fates. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):7882-7.
    View in: PubMed
  13. Punzo C, Xiong W, Cepko CL. Loss of daylight vision in retinal degeneration: are oxidative stress and metabolic dysregulation to blame? J Biol Chem. 2012 Jan 13; 287(3):1642-8.
    View in: PubMed
  14. Emerson MM, Cepko CL. Identification of a retina-specific Otx2 enhancer element active in immature developing photoreceptors. Dev Biol. 2011 Dec 1; 360(1):241-55.
    View in: PubMed
  15. Tang M, Chen B, Lin T, Li Z, Pardo C, Pampo C, Chen J, Lien CL, Wu L, Ai L, Wang H, Yao K, Oh SP, Seto E, Smith LE, Siemann DW, Kladde MP, Cepko CL, Lu J. Restraint of angiogenesis by zinc finger transcription factor CTCF-dependent chromatin insulation. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15231-6.
    View in: PubMed
  16. Beier KT, Saunders A, Oldenburg IA, Miyamichi K, Akhtar N, Luo L, Whelan SP, Sabatini B, Cepko CL. Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15414-9.
    View in: PubMed
  17. Cronican JJ, Beier KT, Davis TN, Tseng JC, Li W, Thompson DB, Shih AF, May EM, Cepko CL, Kung AL, Zhou Q, Liu DR. A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo. Chem Biol. 2011 Jul 29; 18(7):833-8.
    View in: PubMed
  18. Cherry TJ, Wang S, Bormuth I, Schwab M, Olson J, Cepko CL. NeuroD factors regulate cell fate and neurite stratification in the developing retina. J Neurosci. 2011 May 18; 31(20):7365-79.
    View in: PubMed
  19. Beier KT, Samson ME, Matsuda T, Cepko CL. Conditional expression of the TVA receptor allows clonal analysis of descendents from Cre-expressing progenitor cells. Dev Biol. 2011 May 15; 353(2):309-20.
    View in: PubMed
  20. Huynh MA, Ikeuchi Y, Netherton S, de la Torre-Ubieta L, Kanadia R, Stegmüller J, Cepko C, Bonni S, Bonni A. An isoform-specific SnoN1-FOXO1 repressor complex controls neuronal morphogenesis and positioning in the mammalian brain. Neuron. 2011 Mar 10; 69(5):930-44.
    View in: PubMed
  21. Billings NA, Emerson MM, Cepko CL. Analysis of thyroid response element activity during retinal development. PLoS One. 2010; 5(10):e13739.
    View in: PubMed
  22. Cronican JJ, Thompson DB, Beier KT, McNaughton BR, Cepko CL, Liu DR. Potent delivery of functional proteins into Mammalian cells in vitro and in vivo using a supercharged protein. ACS Chem Biol. 2010 Aug 20; 5(8):747-52.
    View in: PubMed
  23. Cepko C. Neuroscience. Seeing the light of day. Science. 2010 Jul 23; 329(5990):403-4.
    View in: PubMed
  24. Rompani SB, Cepko CL. A common progenitor for retinal astrocytes and oligodendrocytes. J Neurosci. 2010 Apr 7; 30(14):4970-80.
    View in: PubMed
  25. Bienvenu F, Jirawatnotai S, Elias JE, Meyer CA, Mizeracka K, Marson A, Frampton GM, Cole MF, Odom DT, Odajima J, Geng Y, Zagozdzon A, Jecrois M, Young RA, Liu XS, Cepko CL, Gygi SP, Sicinski P. Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen. Nature. 2010 Jan 21; 463(7279):374-8.
    View in: PubMed
  26. Kanadia RN, Cepko CL. Alternative splicing produces high levels of noncoding isoforms of bHLH transcription factors during development. Genes Dev. 2010 Feb 1; 24(3):229-34.
    View in: PubMed
  27. Samson M, Emerson MM, Cepko CL. Robust marking of photoreceptor cells and pinealocytes with several reporters under control of the Crx gene. Dev Dyn. 2009 Dec; 238(12):3218-25.
    View in: PubMed
  28. Trimarchi JM, Cho SH, Cepko CL. Identification of genes expressed preferentially in the developing peripheral margin of the optic cup. Dev Dyn. 2009 Sep; 238(9):2327-9.
    View in: PubMed
  29. Cherry TJ, Trimarchi JM, Stadler MB, Cepko CL. Development and diversification of retinal amacrine interneurons at single cell resolution. Proc Natl Acad Sci U S A. 2009 Jun 9; 106(23):9495-500.
    View in: PubMed
  30. Jadhav AP, Roesch K, Cepko CL. Development and neurogenic potential of Müller glial cells in the vertebrate retina. Prog Retin Eye Res. 2009 Jul; 28(4):249-62.
    View in: PubMed
  31. Dyer MA, Martins R, da Silva Filho M, Muniz JA, Silveira LC, Cepko CL, Finlay BL. Developmental sources of conservation and variation in the evolution of the primate eye. Proc Natl Acad Sci U S A. 2009 Jun 2; 106(22):8963-8.
    View in: PubMed
  32. Chen B, Cepko CL. HDAC4 regulates neuronal survival in normal and diseased retinas. Science. 2009 Jan 9; 323(5911):256-9.
    View in: PubMed
  33. Punzo C, Kornacker K, Cepko CL. Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa. Nat Neurosci. 2009 Jan; 12(1):44-52.
    View in: PubMed
  34. Kanadia RN, Clark VE, Punzo C, Trimarchi JM, Cepko CL. Temporal requirement of the alternative-splicing factor Sfrs1 for the survival of retinal neurons. Development. 2008 Dec; 135(23):3923-33.
    View in: PubMed
  35. Trimarchi JM, Harpavat S, Billings NA, Cepko CL. Thyroid hormone components are expressed in three sequential waves during development of the chick retina. BMC Dev Biol. 2008; 8:101.
    View in: PubMed
  36. Kim DS, Matsuda T, Cepko CL. A core paired-type and POU homeodomain-containing transcription factor program drives retinal bipolar cell gene expression. J Neurosci. 2008 Jul 30; 28(31):7748-64.
    View in: PubMed
  37. Roesch K, Jadhav AP, Trimarchi JM, Stadler MB, Roska B, Sun BB, Cepko CL. The transcriptome of retinal Müller glial cells. J Comp Neurol. 2008 Jul 10; 509(2):225-38.
    View in: PubMed
  38. Damiani D, Alexander JJ, O'Rourke JR, McManus M, Jadhav AP, Cepko CL, Hauswirth WW, Harfe BD, Strettoi E. Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina. J Neurosci. 2008 May 7; 28(19):4878-87.
    View in: PubMed
  39. Lagali PS, Balya D, Awatramani GB, Münch TA, Kim DS, Busskamp V, Cepko CL, Roska B. Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration. Nat Neurosci. 2008 Jun; 11(6):667-75.
    View in: PubMed
  40. Kim DS, Ross SE, Trimarchi JM, Aach J, Greenberg ME, Cepko CL. Identification of molecular markers of bipolar cells in the murine retina. J Comp Neurol. 2008 Apr 10; 507(5):1795-810.
    View in: PubMed
  41. Punzo C, Cepko CL. Ultrasound-guided in utero injections allow studies of the development and function of the eye. Dev Dyn. 2008 Apr; 237(4):1034-42.
    View in: PubMed
  42. Trimarchi JM, Stadler MB, Cepko CL. Individual retinal progenitor cells display extensive heterogeneity of gene expression. PLoS One. 2008; 3(2):e1588.
    View in: PubMed
  43. Morrow EM, Chen CM, Cepko CL. Temporal order of bipolar cell genesis in the neural retina. Neural Dev. 2008; 3:2.
    View in: PubMed
  44. Matsuda T, Cepko CL. Analysis of gene function in the retina. Methods Mol Biol. 2008; 423:259-78.
    View in: PubMed
  45. Rompani SB, Cepko CL. Retinal progenitor cells can produce restricted subsets of horizontal cells. Proc Natl Acad Sci U S A. 2008 Jan 8; 105(1):192-7.
    View in: PubMed
  46. Hsiau TH, Diaconu C, Myers CA, Lee J, Cepko CL, Corbo JC. The cis-regulatory logic of the mammalian photoreceptor transcriptional network. PLoS One. 2007; 2(7):e643.
    View in: PubMed
  47. Corbo JC, Myers CA, Lawrence KA, Jadhav AP, Cepko CL. A typology of photoreceptor gene expression patterns in the mouse. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):12069-74.
    View in: PubMed
  48. Chen B, Cepko CL. Requirement of histone deacetylase activity for the expression of critical photoreceptor genes. BMC Dev Biol. 2007; 7:78.
    View in: PubMed
  49. Trimarchi JM, Stadler MB, Roska B, Billings N, Sun B, Bartch B, Cepko CL. Molecular heterogeneity of developing retinal ganglion and amacrine cells revealed through single cell gene expression profiling. J Comp Neurol. 2007 Jun 20; 502(6):1047-65.
    View in: PubMed
  50. Viney TJ, Balint K, Hillier D, Siegert S, Boldogkoi Z, Enquist LW, Meister M, Cepko CL, Roska B. Local retinal circuits of melanopsin-containing ganglion cells identified by transsynaptic viral tracing. Curr Biol. 2007 Jun 5; 17(11):981-8.
    View in: PubMed
  51. Galante PA, Trimarchi J, Cepko CL, de Souza SJ, Ohno-Machado L, Kuo WP. Automatic correspondence of tags and genes (ACTG): a tool for the analysis of SAGE, MPSS and SBS data. Bioinformatics. 2007 Apr 1; 23(7):903-5.
    View in: PubMed
  52. Punzo C, Cepko C. Cellular responses to photoreceptor death in the rd1 mouse model of retinal degeneration. Invest Ophthalmol Vis Sci. 2007 Feb; 48(2):849-57.
    View in: PubMed
  53. Matsuda T, Cepko CL. Controlled expression of transgenes introduced by in vivo electroporation. Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):1027-32.
    View in: PubMed
  54. Jadhav AP, Cho SH, Cepko CL. Notch activity permits retinal cells to progress through multiple progenitor states and acquire a stem cell property. Proc Natl Acad Sci U S A. 2006 Dec 12; 103(50):18998-9003.
    View in: PubMed
  55. Young-Pearse TL, Ivic L, Kriegstein AR, Cepko CL. Characterization of mice with targeted deletion of glycine receptor alpha 2. Mol Cell Biol. 2006 Aug; 26(15):5728-34.
    View in: PubMed
  56. Cho SH, Cepko CL. Wnt2b/beta-catenin-mediated canonical Wnt signaling determines the peripheral fates of the chick eye. Development. 2006 Aug; 133(16):3167-77.
    View in: PubMed
  57. Wildner H, Müller T, Cho SH, Bröhl D, Cepko CL, Guillemot F, Birchmeier C. dILA neurons in the dorsal spinal cord are the product of terminal and non-terminal asymmetric progenitor cell divisions, and require Mash1 for their development. Development. 2006 Jun; 133(11):2105-13.
    View in: PubMed
  58. Jadhav AP, Mason HA, Cepko CL. Notch 1 inhibits photoreceptor production in the developing mammalian retina. Development. 2006 Mar; 133(5):913-23.
    View in: PubMed
  59. Harpavat S, Cepko CL. RCAS-RNAi: a loss-of-function method for the developing chick retina. BMC Dev Biol. 2006; 6:2.
    View in: PubMed
  60. Cepko CL. Effect of gene expression on cone survival in retinitis pigmentosa. Retina. 2005 Dec; 25(8 Suppl):S21-S24.
    View in: PubMed
  61. Sen J, Harpavat S, Peters MA, Cepko CL. Retinoic acid regulates the expression of dorsoventral topographic guidance molecules in the chick retina. Development. 2005 Dec; 132(23):5147-59.
    View in: PubMed
  62. Corbo JC, Cepko CL. A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome. PLoS Genet. 2005 Aug; 1(2):e11.
    View in: PubMed
  63. Rowan S, Cepko CL. A POU factor binding site upstream of the Chx10 homeobox gene is required for Chx10 expression in subsets of retinal progenitor cells and bipolar cells. Dev Biol. 2005 May 15; 281(2):240-55.
    View in: PubMed
  64. Young TL, Matsuda T, Cepko CL. The noncoding RNA taurine upregulated gene 1 is required for differentiation of the murine retina. Curr Biol. 2005 Mar 29; 15(6):501-12.
    View in: PubMed
  65. Schulte D, Peters MA, Sen J, Cepko CL. The rod photoreceptor pattern is set at the optic vesicle stage and requires spatially restricted cVax expression. J Neurosci. 2005 Mar 16; 25(11):2823-31.
    View in: PubMed
  66. Morrow EM, Furukawa T, Raviola E, Cepko CL. Synaptogenesis and outer segment formation are perturbed in the neural retina of Crx mutant mice. BMC Neurosci. 2005; 6:5.
    View in: PubMed
  67. Kim JS, Coon SL, Blackshaw S, Cepko CL, Møller M, Mukda S, Zhao WQ, Charlton CG, Klein DC. Methionine adenosyltransferase:adrenergic-cAMP mechanism regulates a daily rhythm in pineal expression. J Biol Chem. 2005 Jan 7; 280(1):677-84.
    View in: PubMed
  68. Rowan S, Chen CM, Young TL, Fisher DE, Cepko CL. Transdifferentiation of the retina into pigmented cells in ocular retardation mice defines a new function of the homeodomain gene Chx10. Development. 2004 Oct; 131(20):5139-52.
    View in: PubMed
  69. Rowan S, Cepko CL. Genetic analysis of the homeodomain transcription factor Chx10 in the retina using a novel multifunctional BAC transgenic mouse reporter. Dev Biol. 2004 Jul 15; 271(2):388-402.
    View in: PubMed
  70. Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL. Genomic analysis of mouse retinal development. PLoS Biol. 2004 Sep; 2(9):E247.
    View in: PubMed
  71. Young TL, Cepko CL. A role for ligand-gated ion channels in rod photoreceptor development. Neuron. 2004 Mar 25; 41(6):867-79.
    View in: PubMed
  72. Zhang J, Gray J, Wu L, Leone G, Rowan S, Cepko CL, Zhu X, Craft CM, Dyer MA. Rb regulates proliferation and rod photoreceptor development in the mouse retina. Nat Genet. 2004 Apr; 36(4):351-60.
    View in: PubMed
  73. Pignatelli V, Cepko CL, Strettoi E. Inner retinal abnormalities in a mouse model of Leber's congenital amaurosis. J Comp Neurol. 2004 Feb 9; 469(3):351-9.
    View in: PubMed
  74. Livesey FJ, Young TL, Cepko CL. An analysis of the gene expression program of mammalian neural progenitor cells. Proc Natl Acad Sci U S A. 2004 Feb 3; 101(5):1374-9.
    View in: PubMed
  75. Matsuda T, Cepko CL. Electroporation and RNA interference in the rodent retina in vivo and in vitro. Proc Natl Acad Sci U S A. 2004 Jan 6; 101(1):16-22.
    View in: PubMed
  76. Harpavat S, Cepko CL. Thyroid hormone and retinal development: an emerging field. Thyroid. 2003 Nov; 13(11):1013-9.
    View in: PubMed
  77. Dyer MA, Livesey FJ, Cepko CL, Oliver G. Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina. Nat Genet. 2003 May; 34(1):53-8.
    View in: PubMed
  78. Jin Z, Zhang J, Klar A, Chédotal A, Rao Y, Cepko CL, Bao ZZ. Irx4-mediated regulation of Slit1 expression contributes to the definition of early axonal paths inside the retina. Development. 2003 Mar; 130(6):1037-48.
    View in: PubMed
  79. Blackshaw S, Kuo WP, Park PJ, Tsujikawa M, Gunnersen JM, Scott HS, Boon WM, Tan SS, Cepko CL. MicroSAGE is highly representative and reproducible but reveals major differences in gene expression among samples obtained from similar tissues. Genome Biol. 2003; 4(3):R17.
    View in: PubMed
  80. Blackshaw S, Cepko CL. Stem cells that know their place. Nat Neurosci. 2002 Dec; 5(12):1251-2.
    View in: PubMed
  81. Chen CM, Cepko CL. The chicken RaxL gene plays a role in the initiation of photoreceptor differentiation. Development. 2002 Dec; 129(23):5363-75.
    View in: PubMed
  82. Peters MA, Cepko CL. The dorsal-ventral axis of the neural retina is divided into multiple domains of restricted gene expression which exhibit features of lineage compartments. Dev Biol. 2002 Nov 1; 251(1):59-73.
    View in: PubMed
  83. Goh KL, Cai L, Cepko CL, Gertler FB. Ena/VASP proteins regulate cortical neuronal positioning. Curr Biol. 2002 Apr 2; 12(7):565-9.
    View in: PubMed
  84. Furukawa A, Koike C, Lippincott P, Cepko CL, Furukawa T. The mouse Crx 5'-upstream transgene sequence directs cell-specific and developmentally regulated expression in retinal photoreceptor cells. J Neurosci. 2002 Mar 1; 22(5):1640-7.
    View in: PubMed
  85. Bowne SJ, Sullivan LS, Blanton SH, Cepko CL, Blackshaw S, Birch DG, Hughbanks-Wheaton D, Heckenlively JR, Daiger SP. Mutations in the inosine monophosphate dehydrogenase 1 gene (IMPDH1) cause the RP10 form of autosomal dominant retinitis pigmentosa. Hum Mol Genet. 2002 Mar 1; 11(5):559-68.
    View in: PubMed
  86. Szele FG, Chin HK, Rowlson MA, Cepko CL. Sox-9 and cDachsund-2 expression in the developing chick telencephalon. Mech Dev. 2002 Mar; 112(1-2):179-82.
    View in: PubMed
  87. Sharon D, Blackshaw S, Cepko CL, Dryja TP. Profile of the genes expressed in the human peripheral retina, macula, and retinal pigment epithelium determined through serial analysis of gene expression (SAGE). Proc Natl Acad Sci U S A. 2002 Jan 8; 99(1):315-20.
    View in: PubMed
  88. Blackshaw S, Fraioli RE, Furukawa T, Cepko CL. Comprehensive analysis of photoreceptor gene expression and the identification of candidate retinal disease genes. Cell. 2001 Nov 30; 107(5):579-89.
    View in: PubMed
  89. Chang B, Smith RS, Peters M, Savinova OV, Hawes NL, Zabaleta A, Nusinowitz S, Martin JE, Davisson ML, Cepko CL, Hogan BL, John SW. Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure. BMC Genet. 2001; 2:18.
    View in: PubMed
  90. Cepko CL. Tackling the brain's genetic complexity. Nat Neurosci. 2001 Nov; 4 Suppl:1159-60.
    View in: PubMed
  91. Livesey R, Cepko C. Neurobiology. Developing order. Nature. 2001 Oct 4; 413(6855):471, 473.
    View in: PubMed
  92. Lu QR, Cai L, Rowitch D, Cepko CL, Stiles CD. Ectopic expression of Olig1 promotes oligodendrocyte formation and reduces neuronal survival in developing mouse cortex. Nat Neurosci. 2001 Oct; 4(10):973-4.
    View in: PubMed
  93. Dyer MA, Cepko CL. p27Kip1 and p57Kip2 regulate proliferation in distinct retinal progenitor cell populations. J Neurosci. 2001 Jun 15; 21(12):4259-71.
    View in: PubMed
  94. Cepko C, Pear W. Overview of the retrovirus transduction system. Curr Protoc Mol Biol. 2001 May; Chapter 9:Unit9.9.
    View in: PubMed
  95. Cepko C. Large-scale preparation and concentration of retrovirus stocks. Curr Protoc Mol Biol. 2001 May; Chapter 9:Unit9.12.
    View in: PubMed
  96. Cepko C, Pear W. Retrovirus infection of cells in vitro and in vivo. Curr Protoc Mol Biol. 2001 May; Chapter 9:Unit9.14.
    View in: PubMed
  97. Cepko C, Pear W. Detection of helper virus in retrovirus stocks. Curr Protoc Mol Biol. 2001 May; Chapter 9:Unit9.13.
    View in: PubMed
  98. Dyer MA, Cepko CL. Regulating proliferation during retinal development. Nat Rev Neurosci. 2001 May; 2(5):333-42.
    View in: PubMed
  99. Cepko C. Preparation of a specific retrovirus producer cell line. Curr Protoc Mol Biol. 2001 May; Chapter 9:Unit9.10.
    View in: PubMed
  100. Bruneau BG, Bao ZZ, Fatkin D, Xavier-Neto J, Georgakopoulos D, Maguire CT, Berul CI, Kass DA, Kuroski-de Bold ML, de Bold AJ, Conner DA, Rosenthal N, Cepko CL, Seidman CE, Seidman JG. Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression. Mol Cell Biol. 2001 Mar; 21(5):1730-6.
    View in: PubMed
  101. Livesey FJ, Cepko CL. Vertebrate neural cell-fate determination: lessons from the retina. Nat Rev Neurosci. 2001 Feb; 2(2):109-18.
    View in: PubMed
  102. Dyer MA, Cepko CL. The p57Kip2 cyclin kinase inhibitor is expressed by a restricted set of amacrine cells in the rodent retina. J Comp Neurol. 2001 Jan 22; 429(4):601-14.
    View in: PubMed
  103. Lin JC, Cai L, Cepko CL. The external granule layer of the developing chick cerebellum generates granule cells and cells of the isthmus and rostral hindbrain. J Neurosci. 2001 Jan 1; 21(1):159-68.
    View in: PubMed
  104. Cepko CL. Genomics approaches to photoreceptor development and disease. Harvey Lect. 2001-2002; 97:85-110.
    View in: PubMed
  105. Schulte D, Cepko CL. Two homeobox genes define the domain of EphA3 expression in the developing chick retina. Development. 2000 Dec; 127(23):5033-45.
    View in: PubMed
  106. Dyer MA, Cepko CL. Control of Müller glial cell proliferation and activation following retinal injury. Nat Neurosci. 2000 Sep; 3(9):873-80.
    View in: PubMed
  107. Dyer MA, Cepko CL. p57(Kip2) regulates progenitor cell proliferation and amacrine interneuron development in the mouse retina. Development. 2000 Aug; 127(16):3593-605.
    View in: PubMed
  108. Liu W, Khare SL, Liang X, Peters MA, Liu X, Cepko CL, Xiang M. All Brn3 genes can promote retinal ganglion cell differentiation in the chick. Development. 2000 Aug; 127(15):3237-47.
    View in: PubMed
  109. Cai L, Morrow EM, Cepko CL. Misexpression of basic helix-loop-helix genes in the murine cerebral cortex affects cell fate choices and neuronal survival. Development. 2000 Jul; 127(14):3021-30.
    View in: PubMed
  110. Furukawa T, Mukherjee S, Bao ZZ, Morrow EM, Cepko CL. rax, Hes1, and notch1 promote the formation of Müller glia by postnatal retinal progenitor cells. Neuron. 2000 May; 26(2):383-94.
    View in: PubMed
  111. Livesey FJ, Furukawa T, Steffen MA, Church GM, Cepko CL. Microarray analysis of the transcriptional network controlled by the photoreceptor homeobox gene Crx. Curr Biol. 2000 Mar 23; 10(6):301-10.
    View in: PubMed
  112. Belliveau MJ, Young TL, Cepko CL. Late retinal progenitor cells show intrinsic limitations in the production of cell types and the kinetics of opsin synthesis. J Neurosci. 2000 Mar 15; 20(6):2247-54.
    View in: PubMed
  113. Chen CM, Cepko CL. Expression of Chx10 and Chx10-1 in the developing chicken retina. Mech Dev. 2000 Feb; 90(2):293-7.
    View in: PubMed
  114. Cepko C. Giving in to the blues. Nat Genet. 2000 Feb; 24(2):99-100.
    View in: PubMed
  115. Bruneau BG, Bao ZZ, Tanaka M, Schott JJ, Izumo S, Cepko CL, Seidman JG, Seidman CE. Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand. Dev Biol. 2000 Jan 15; 217(2):266-77.
    View in: PubMed
  116. Sohocki MM, Bowne SJ, Sullivan LS, Blackshaw S, Cepko CL, Payne AM, Bhattacharya SS, Khaliq S, Qasim Mehdi S, Birch DG, Harrison WR, Elder FF, Heckenlively JR, Daiger SP. Mutations in a new photoreceptor-pineal gene on 17p cause Leber congenital amaurosis. Nat Genet. 2000 Jan; 24(1):79-83.
    View in: PubMed
  117. Cepko CL, Ryder E, Austin C, Golden J, Fields-Berry S, Lin J. Lineage analysis with retroviral vectors. Methods Enzymol. 2000; 327:118-45.
    View in: PubMed
  118. Furukawa T, Morrow EM, Li T, Davis FC, Cepko CL. Retinopathy and attenuated circadian entrainment in Crx-deficient mice. Nat Genet. 1999 Dec; 23(4):466-70.
    View in: PubMed
  119. Schulte D, Furukawa T, Peters MA, Kozak CA, Cepko CL. Misexpression of the Emx-related homeobox genes cVax and mVax2 ventralizes the retina and perturbs the retinotectal map. Neuron. 1999 Nov; 24(3):541-53.
    View in: PubMed
  120. Chen CM, Smith DM, Peters MA, Samson ME, Zitz J, Tabin CJ, Cepko CL. Production and design of more effective avian replication-incompetent retroviral vectors. Dev Biol. 1999 Oct 15; 214(2):370-84.
    View in: PubMed
  121. Lin JC, Cepko CL. Biphasic dispersion of clones containing Purkinje cells and glia in the developing chick cerebellum. Dev Biol. 1999 Jul 15; 211(2):177-97.
    View in: PubMed
  122. Bao ZZ, Bruneau BG, Seidman JG, Seidman CE, Cepko CL. Regulation of chamber-specific gene expression in the developing heart by Irx4. Science. 1999 Feb 19; 283(5405):1161-4.
    View in: PubMed
  123. Cepko CL. The roles of intrinsic and extrinsic cues and bHLH genes in the determination of retinal cell fates. Curr Opin Neurobiol. 1999 Feb; 9(1):37-46.
    View in: PubMed
  124. Belliveau MJ, Cepko CL. Extrinsic and intrinsic factors control the genesis of amacrine and cone cells in the rat retina. Development. 1999 Feb; 126(3):555-66.
    View in: PubMed
  125. Morrow EM, Furukawa T, Lee JE, Cepko CL. NeuroD regulates multiple functions in the developing neural retina in rodent. Development. 1999 Jan; 126(1):23-36.
    View in: PubMed
  126. Lin JC, Cepko CL. Granule cell raphes and parasagittal domains of Purkinje cells: complementary patterns in the developing chick cerebellum. J Neurosci. 1998 Nov 15; 18(22):9342-53.
    View in: PubMed
  127. Morrow EM, Furukawa T, Cepko CL. Vertebrate photoreceptor cell development and disease. Trends Cell Biol. 1998 Sep; 8(9):353-8.
    View in: PubMed
  128. Ma C, Papermaster D, Cepko CL. A unique pattern of photoreceptor degeneration in cyclin D1 mutant mice. Proc Natl Acad Sci U S A. 1998 Aug 18; 95(17):9938-43.
    View in: PubMed
  129. Morrow EM, Belliveau MJ, Cepko CL. Two phases of rod photoreceptor differentiation during rat retinal development. J Neurosci. 1998 May 15; 18(10):3738-48.
    View in: PubMed
  130. Cepko CL, Ryder E, Austin C, Golden J, Fields-Berry S, Lin J. Lineage analysis using retroviral vectors. Methods. 1998 Apr; 14(4):393-406.
    View in: PubMed
  131. Szele FG, Cepko CL. The dispersion of clonally related cells in the developing chick telencephalon. Dev Biol. 1998 Mar 15; 195(2):100-13.
    View in: PubMed
  132. Cepko CL, Fields-Berry S, Ryder E, Austin C, Golden J. Lineage analysis using retroviral vectors. Curr Top Dev Biol. 1998; 36:51-74.
    View in: PubMed
  133. Freund CL, Gregory-Evans CY, Furukawa T, Papaioannou M, Looser J, Ploder L, Bellingham J, Ng D, Herbrick JA, Duncan A, Scherer SW, Tsui LC, Loutradis-Anagnostou A, Jacobson SG, Cepko CL, Bhattacharya SS, McInnes RR. Cone-rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor. Cell. 1997 Nov 14; 91(4):543-53.
    View in: PubMed
  134. Furukawa T, Morrow EM, Cepko CL. Crx, a novel otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation. Cell. 1997 Nov 14; 91(4):531-41.
    View in: PubMed
  135. Golden JA, Zitz JC, McFadden K, Cepko CL. Cell migration in the developing chick diencephalon. Development. 1997 Sep; 124(18):3525-33.
    View in: PubMed
  136. Furukawa T, Kozak CA, Cepko CL. rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina. Proc Natl Acad Sci U S A. 1997 Apr 1; 94(7):3088-93.
    View in: PubMed
  137. Alexiades MR, Cepko CL. Subsets of retinal progenitors display temporally regulated and distinct biases in the fates of their progeny. Development. 1997 Mar; 124(6):1119-31.
    View in: PubMed
  138. Ezzeddine ZD, Yang X, DeChiara T, Yancopoulos G, Cepko CL. Postmitotic cells fated to become rod photoreceptors can be respecified by CNTF treatment of the retina. Development. 1997 Mar; 124(5):1055-67.
    View in: PubMed
  139. Bao ZZ, Cepko CL. The expression and function of Notch pathway genes in the developing rat eye. J Neurosci. 1997 Feb 15; 17(4):1425-34.
    View in: PubMed
  140. Szele FG, Cepko CL. A subset of clones in the chick telencephalon arranged in rostrocaudal arrays. Curr Biol. 1996 Dec 1; 6(12):1685-90.
    View in: PubMed
  141. Yang X, Cepko CL. Flk-1, a receptor for vascular endothelial growth factor (VEGF), is expressed by retinal progenitor cells. J Neurosci. 1996 Oct 1; 16(19):6089-99.
    View in: PubMed
  142. Cepko CL. The patterning and onset of opsin expression in vertebrate retinae. Curr Opin Neurobiol. 1996 Aug; 6(4):542-6.
    View in: PubMed
  143. Alexiades MR, Cepko C. Quantitative analysis of proliferation and cell cycle length during development of the rat retina. Dev Dyn. 1996 Mar; 205(3):293-307.
    View in: PubMed
  144. Bruhn SL, Cepko CL. Development of the pattern of photoreceptors in the chick retina. J Neurosci. 1996 Feb 15; 16(4):1430-9.
    View in: PubMed
  145. Cepko CL, Austin CP, Yang X, Alexiades M, Ezzeddine D. Cell fate determination in the vertebrate retina. Proc Natl Acad Sci U S A. 1996 Jan 23; 93(2):589-95.
    View in: PubMed
  146. Arnold-Aldea SA, Cepko CL. Dispersion patterns of clonally related cells during development of the hypothalamus. Dev Biol. 1996 Jan 10; 173(1):148-61.
    View in: PubMed
  147. Golden JA, Cepko CL. Clones in the chick diencephalon contain multiple cell types and siblings are widely dispersed. Development. 1996 Jan; 122(1):65-78.
    View in: PubMed
  148. Austin CP, Feldman DE, Ida JA, Cepko CL. Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch. Development. 1995 Nov; 121(11):3637-50.
    View in: PubMed
  149. Golden JA, Fields-Berry SC, Cepko CL. Construction and characterization of a highly complex retroviral library for lineage analysis. Proc Natl Acad Sci U S A. 1995 Jun 6; 92(12):5704-8.
    View in: PubMed
  150. Cepko C, Ryder EF, Austin CP, Walsh C, Fekete DM. Lineage analysis using retrovirus vectors. Methods Enzymol. 1995; 254:387-419.
    View in: PubMed
  151. Fekete DM, Perez-Miguelsanz J, Ryder EF, Cepko CL. Clonal analysis in the chicken retina reveals tangential dispersion of clonally related cells. Dev Biol. 1994 Dec; 166(2):666-82.
    View in: PubMed
  152. Ryder EF, Cepko CL. Migration patterns of clonally related granule cells and their progenitors in the developing chick cerebellum. Neuron. 1994 May; 12(5):1011-28.
    View in: PubMed
  153. Wu DK, Cepko CL. The stability of endogenous tyrosine hydroxylase protein in PC-12 cells differs from that expressed in mouse fibroblasts by gene transfer. J Neurochem. 1994 Mar; 62(3):863-72.
    View in: PubMed
  154. Deitcher DL, Fekete DM, Cepko CL. Asymmetric expression of a novel homeobox gene in vertebrate sensory organs. J Neurosci. 1994 Feb; 14(2):486-98.
    View in: PubMed
  155. Austin CP, Cepko CL. Retrovirus mediated gene transduction into the vertebrate CNS. Gene Ther. 1994; 1 Suppl 1:S6-9.
    View in: PubMed
  156. Altshuler D, Lo Turco JJ, Rush J, Cepko C. Taurine promotes the differentiation of a vertebrate retinal cell type in vitro. Development. 1993 Dec; 119(4):1317-28.
    View in: PubMed
  157. Sucher NJ, Brose N, Deitcher DL, Awobuluyi M, Gasic GP, Bading H, Cepko CL, Greenberg ME, Jahn R, Heinemann SF, et al. Expression of endogenous NMDAR1 transcripts without receptor protein suggests post-transcriptional control in PC12 cells. J Biol Chem. 1993 Oct 25; 268(30):22299-304.
    View in: PubMed
  158. Wu DK, Cepko CL. Development of dopaminergic neurons is insensitive to optic nerve section in the neonatal rat retina. Brain Res Dev Brain Res. 1993 Aug 20; 74(2):253-60.
    View in: PubMed
  159. Nirenberg S, Cepko C. Targeted ablation of diverse cell classes in the nervous system in vivo. J Neurosci. 1993 Aug; 13(8):3238-51.
    View in: PubMed
  160. Yang X, Chung D, Cepko CL. Molecular cloning of the murine JAK1 protein tyrosine kinase and its expression in the mouse central nervous system. J Neurosci. 1993 Jul; 13(7):3006-17.
    View in: PubMed
  161. Walsh C, Cepko CL. Clonal dispersion in proliferative layers of developing cerebral cortex. Nature. 1993 Apr 15; 362(6421):632-5.
    View in: PubMed
  162. Fekete DM, Cepko CL. Replication-competent retroviral vectors encoding alkaline phosphatase reveal spatial restriction of viral gene expression/transduction in the chick embryo. Mol Cell Biol. 1993 Apr; 13(4):2604-13.
    View in: PubMed
  163. Fekete DM, Cepko CL. Retroviral infection coupled with tissue transplantation limits gene transfer in the chicken embryo. Proc Natl Acad Sci U S A. 1993 Mar 15; 90(6):2350-4.
    View in: PubMed
  164. Cepko CL, Ryder EF, Austin CP, Walsh C, Fekete DM. Lineage analysis using retrovirus vectors. Methods Enzymol. 1993; 225:933-60.
    View in: PubMed
  165. Halliday AL, Cepko CL. Generation and migration of cells in the developing striatum. Neuron. 1992 Jul; 9(1):15-26.
    View in: PubMed
  166. Lillien L, Cepko C. Control of proliferation in the retina: temporal changes in responsiveness to FGF and TGF alpha. Development. 1992 May; 115(1):253-66.
    View in: PubMed
  167. Altshuler D, Cepko C. A temporally regulated, diffusible activity is required for rod photoreceptor development in vitro. Development. 1992 Apr; 114(4):947-57.
    View in: PubMed
  168. Guillemot F, Cepko CL. Retinal fate and ganglion cell differentiation are potentiated by acidic FGF in an in vitro assay of early retinal development. Development. 1992 Mar; 114(3):743-54.
    View in: PubMed
  169. Walsh C, Cepko CL. Widespread dispersion of neuronal clones across functional regions of the cerebral cortex. Science. 1992 Jan 24; 255(5043):434-40.
    View in: PubMed
  170. Fields-Berry SC, Halliday AL, Cepko CL. A recombinant retrovirus encoding alkaline phosphatase confirms clonal boundary assignment in lineage analysis of murine retina. Proc Natl Acad Sci U S A. 1992 Jan 15; 89(2):693-7.
    View in: PubMed
  171. Snyder EY, Deitcher DL, Walsh C, Arnold-Aldea S, Hartwieg EA, Cepko CL. Multipotent neural cell lines can engraft and participate in development of mouse cerebellum. Cell. 1992 Jan 10; 68(1):33-51.
    View in: PubMed
  172. Misson JP, Austin CP, Takahashi T, Cepko CL, Caviness VS. The alignment of migrating neural cells in relation to the murine neopallial radial glial fiber system. Cereb Cortex. 1991 May-Jun; 1(3):221-9.
    View in: PubMed
  173. Austin CP, Cepko CL. Cellular migration patterns in the developing mouse cerebral cortex. Development. 1990 Nov; 110(3):713-32.
    View in: PubMed
  174. Walsh C, Cepko CL. Cell lineage and cell migration in the developing cerebral cortex. Experientia. 1990 Sep 15; 46(9):940-7.
    View in: PubMed
  175. Turner DL, Snyder EY, Cepko CL. Lineage-independent determination of cell type in the embryonic mouse retina. Neuron. 1990 Jun; 4(6):833-45.
    View in: PubMed
  176. Ryder EF, Snyder EY, Cepko CL. Establishment and characterization of multipotent neural cell lines using retrovirus vector-mediated oncogene transfer. J Neurobiol. 1990 Mar; 21(2):356-75.
    View in: PubMed
  177. Cepko CL, Austin CP, Walsh C, Ryder EF, Halliday A, Fields-Berry S. Studies of cortical development using retrovirus vectors. Cold Spring Harb Symp Quant Biol. 1990; 55:265-78.
    View in: PubMed
  178. Cepko CL. Immortalization of neural cells via retrovirus-mediated oncogene transduction. Annu Rev Neurosci. 1989; 12:47-65.
    View in: PubMed
  179. Walsh C, Cepko CL. Clonally related cortical cells show several migration patterns. Science. 1988 Sep 9; 241(4871):1342-5.
    View in: PubMed
  180. Cepko C. Retrovirus vectors and their applications in neurobiology. Neuron. 1988 Jul; 1(5):345-53.
    View in: PubMed
  181. Wolf D, Richter-Landsberg C, Short MP, Cepko C, Breakefield XO. Retrovirus-mediated gene transfer of beta-nerve growth factor into mouse pituitary line AtT-20. Mol Biol Med. 1988 Feb; 5(1):43-59.
    View in: PubMed
  182. Turner DL, Cepko CL. A common progenitor for neurons and glia persists in rat retina late in development. Nature. 1987 Jul 9-15; 328(6126):131-6.
    View in: PubMed
  183. Price J, Turner D, Cepko C. Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer. Proc Natl Acad Sci U S A. 1987 Jan; 84(1):156-60.
    View in: PubMed
  184. Jat PS, Cepko CL, Mulligan RC, Sharp PA. Recombinant retroviruses encoding simian virus 40 large T antigen and polyomavirus large and middle T antigens. Mol Cell Biol. 1986 Apr; 6(4):1204-17.
    View in: PubMed
  185. Roberts BE, Miller JS, Kimelman D, Cepko CL, Lemischka IR, Mulligan RC. Individual adenovirus type 5 early region 1A gene products elicit distinct alterations of cellular morphology and gene expression. J Virol. 1985 Nov; 56(2):404-13.
    View in: PubMed
  186. Cepko CL, Roberts BE, Mulligan RC. Construction and applications of a highly transmissible murine retrovirus shuttle vector. Cell. 1984 Jul; 37(3):1053-62.
    View in: PubMed
  187. Cepko CL, Sharp PA. Analysis of Ad5 hexon and 100K ts mutants using conformation-specific monoclonal antibodies. Virology. 1983 Aug; 129(1):137-54.
    View in: PubMed
  188. Cepko CL, Sharp PA. Assembly of adenovirus major capsid protein is mediated by a nonvirion protein. Cell. 1982 Dec; 31(2 Pt 1):407-15.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Cepko's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
Co-Authors
_
Similar People
_
Same Department
Physical Neighbors
_