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Last Name
Institution

Timothy J. Mitchison, Ph.D.

TitleHasib Sabbagh Professor of Systems Biology
InstitutionHarvard Medical School
DepartmentSystems Biology
AddressHarvard Medical School
Alpert 536, Systems Biology
200 Longwood Ave
Boston MA 02115
Phone617/432-3805
Fax617/432-3702
Other Positions
TitleDeputy Chairman of the Department of Systems Biology
InstitutionHarvard Medical School
DepartmentSystems Biology


 Mentoring 
 completed student projects
Elucidation of Mechanism of Action of Cell Motility Inhibitors in a Wound-Healing Assay
Summer, 05/22/00 - 08/01/00
Using Small Molecules to Perturb and Study Cytoskeletal Function
Summer, 06/01/99 - 08/31/99

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Gatlin JC, Matov A, Danuser G, Mitchison TJ, Salmon ED. Directly probing the mechanical properties of the spindle and its matrix. J Cell Biol. 2010 Feb 22; 188(4):481-9.
    View in: PubMed
  2. Needleman DJ, Groen A, Ohi R, Maresca T, Mirny L, Mitchison T. Fast microtubule dynamics in meiotic spindles measured by single molecule imaging: evidence that the spindle environment does not stabilize microtubules. Mol Biol Cell. 2010 Jan 15; 21(2):323-33.
    View in: PubMed
  3. Huang HC, Shi J, Orth JD, Mitchison TJ. Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly. Cancer Cell. 2009 Oct 6; 16(4):347-58.
    View in: PubMed
  4. Tsui M, Xie T, Orth JD, Carpenter AE, Rudnicki S, Kim S, Shamu CE, Mitchison TJ. An intermittent live cell imaging screen for siRNA enhancers and suppressors of a kinesin-5 inhibitor. PLoS One. 2009; 4(10):e7339.
    View in: PubMed
  5. Ozlü N, Monigatti F, Renard BY, Field CM, Steen H, Mitchison TJ, Steen JJ. Binding partner switching on microtubules and aurora-B in the mitosis to cytokinesis transition. Mol Cell Proteomics. 2010 Feb; 9(2):336-50.
    View in: PubMed
  6. Chang P, Coughlin M, Mitchison TJ. Interaction between Poly(ADP-ribose) and NuMA contributes to mitotic spindle pole assembly. Mol Biol Cell. 2009 Nov; 20(21):4575-85.
    View in: PubMed
  7. Dumont S, Mitchison TJ. Force and length in the mitotic spindle. Curr Biol. 2009 Sep 15; 19(17):R749-61.
    View in: PubMed
  8. Kueh HY, Mitchison TJ. Structural plasticity in actin and tubulin polymer dynamics. Science. 2009 Aug 21; 325(5943):960-3.
    View in: PubMed
  9. Charras GT, Mitchison TJ, Mahadevan L. Animal cell hydraulics. J Cell Sci. 2009 Sep 15; 122(Pt 18):3233-41.
    View in: PubMed
  10. Feng Y, Mitchison TJ, Bender A, Young DW, Tallarico JA. Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds. Nat Rev Drug Discov. 2009 Jul; 8(7):567-78.
    View in: PubMed
  11. Dumont S, Mitchison TJ. Compression regulates mitotic spindle length by a mechanochemical switch at the poles. Curr Biol. 2009 Jul 14; 19(13):1086-95.
    View in: PubMed
  12. Maresca TJ, Groen AC, Gatlin JC, Ohi R, Mitchison TJ, Salmon ED. Spindle assembly in the absence of a RanGTP gradient requires localized CPC activity. Curr Biol. 2009 Jul 28; 19(14):1210-5.
    View in: PubMed
  13. Needleman DJ, Xu Y, Mitchison TJ. Pin-hole array correlation imaging: highly parallel fluorescence correlation spectroscopy. Biophys J. 2009 Jun 17; 96(12):5050-9.
    View in: PubMed
  14. Niethammer P, Grabher C, Look AT, Mitchison TJ. A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature. 2009 Jun 18; 459(7249):996-9.
    View in: PubMed
  15. Wühr M, Mitchison TJ, Field CM. Size and speed go hand in hand in cytokinesis. Cell. 2009 May 29; 137(5):798-800.
    View in: PubMed
  16. Groen AC, Maresca TJ, Gatlin JC, Salmon ED, Mitchison TJ. Functional overlap of microtubule assembly factors in chromatin-promoted spindle assembly. Mol Biol Cell. 2009 Jun; 20(11):2766-73.
    View in: PubMed
  17. Wühr M, Dumont S, Groen AC, Needleman DJ, Mitchison TJ. How does a millimeter-sized cell find its center? Cell Cycle. 2009 Apr 15; 8(8):1115-21.
    View in: PubMed
  18. Gatlin JC, Matov A, Groen AC, Needleman DJ, Maresca TJ, Danuser G, Mitchison TJ, Salmon ED. Spindle fusion requires dynein-mediated sliding of oppositely oriented microtubules. Curr Biol. 2009 Feb 24; 19(4):287-96.
    View in: PubMed
  19. Orth JD, Tang Y, Shi J, Loy CT, Amendt C, Wilm C, Zenke FT, Mitchison TJ. Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate. Mol Cancer Ther. 2008 Nov; 7(11):3480-9.
    View in: PubMed
  20. Kueh HY, Brieher WM, Mitchison TJ. Dynamic stabilization of actin filaments. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16531-6.
    View in: PubMed
  21. Wühr M, Mitchison TJ, Field CM. Mitosis: new roles for myosin-X and actin at the spindle. Curr Biol. 2008 Oct 14; 18(19):R912-4.
    View in: PubMed
  22. Wühr M, Chen Y, Dumont S, Groen AC, Needleman DJ, Salic A, Mitchison TJ. Evidence for an upper limit to mitotic spindle length. Curr Biol. 2008 Aug 26; 18(16):1256-61.
    View in: PubMed
  23. Kueh HY, Charras GT, Mitchison TJ, Brieher WM. Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers. J Cell Biol. 2008 Jul 28; 182(2):341-53.
    View in: PubMed
  24. Groen AC, Needleman D, Brangwynne C, Gradinaru C, Fowler B, Mazitschek R, Mitchison TJ. A novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly. J Cell Sci. 2008 Jul 15; 121(Pt 14):2293-300.
    View in: PubMed
  25. Shi J, Orth JD, Mitchison T. Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5. Cancer Res. 2008 May 1; 68(9):3269-76.
    View in: PubMed
  26. Hu CK, Coughlin M, Field CM, Mitchison TJ. Cell polarization during monopolar cytokinesis. J Cell Biol. 2008 Apr 21; 181(2):195-202.
    View in: PubMed
  27. Niethammer P, Kueh HY, Mitchison TJ. Spatial patterning of metabolism by mitochondria, oxygen, and energy sinks in a model cytoplasm. Curr Biol. 2008 Apr 22; 18(8):586-91.
    View in: PubMed
  28. Salic A, Mitchison TJ. A chemical method for fast and sensitive detection of DNA synthesis in vivo. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2415-20.
    View in: PubMed
  29. Mitchison TJ, Charras GT, Mahadevan L. Implications of a poroelastic cytoplasm for the dynamics of animal cell shape. Semin Cell Dev Biol. 2008 Jun; 19(3):215-23.
    View in: PubMed
  30. Young DW, Bender A, Hoyt J, McWhinnie E, Chirn GW, Tao CY, Tallarico JA, Labow M, Jenkins JL, Mitchison TJ, Feng Y. Integrating high-content screening and ligand-target prediction to identify mechanism of action. Nat Chem Biol. 2008 Jan; 4(1):59-68.
    View in: PubMed
  31. Galkin VE, Orlova A, Brieher W, Kueh HY, Mitchison TJ, Egelman EH. Coronin-1A stabilizes F-actin by bridging adjacent actin protomers and stapling opposite strands of the actin filament. J Mol Biol. 2008 Feb 22; 376(3):607-13.
    View in: PubMed
  32. Charras GT, Coughlin M, Mitchison TJ, Mahadevan L. Life and times of a cellular bleb. Biophys J. 2008 Mar 1; 94(5):1836-53.
    View in: PubMed
  33. Irimia D, Charras G, Agrawal N, Mitchison T, Toner M. Polar stimulation and constrained cell migration in microfluidic channels. Lab Chip. 2007 Dec; 7(12):1783-90.
    View in: PubMed
  34. Burbank KS, Mitchison TJ, Fisher DS. Slide-and-cluster models for spindle assembly. Curr Biol. 2007 Aug 21; 17(16):1373-83.
    View in: PubMed
  35. Vrabioiu AM, Mitchison TJ. Symmetry of septin hourglass and ring structures. J Mol Biol. 2007 Sep 7; 372(1):37-49.
    View in: PubMed
  36. Ohi R, Burbank K, Liu Q, Mitchison TJ. Nonredundant functions of Kinesin-13s during meiotic spindle assembly. Curr Biol. 2007 Jun 5; 17(11):953-9.
    View in: PubMed
  37. Li J, Brieher WM, Scimone ML, Kang SJ, Zhu H, Yin H, von Andrian UH, Mitchison T, Yuan J. Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization. Nat Cell Biol. 2007 Mar; 9(3):276-86.
    View in: PubMed
  38. Ribbeck K, Mitchison TJ. Meiotic spindle: sculpted by severing. Curr Biol. 2006 Nov 7; 16(21):R923-5.
    View in: PubMed
  39. Burbank KS, Groen AC, Perlman ZE, Fisher DS, Mitchison TJ. A new method reveals microtubule minus ends throughout the meiotic spindle. J Cell Biol. 2006 Nov 6; 175(3):369-75.
    View in: PubMed
  40. Charras GT, Hu CK, Coughlin M, Mitchison TJ. Reassembly of contractile actin cortex in cell blebs. J Cell Biol. 2006 Nov 6; 175(3):477-90.
    View in: PubMed
  41. Brieher WM, Kueh HY, Ballif BA, Mitchison TJ. Rapid actin monomer-insensitive depolymerization of Listeria actin comet tails by cofilin, coronin, and Aip1. J Cell Biol. 2006 Oct 23; 175(2):315-24.
    View in: PubMed
  42. Vrabioiu AM, Mitchison TJ. Structural insights into yeast septin organization from polarized fluorescence microscopy. Nature. 2006 Sep 28; 443(7110):466-9.
    View in: PubMed
  43. Burbank KS, Mitchison TJ. Microtubule dynamic instability. Curr Biol. 2006 Jul 25; 16(14):R516-7.
    View in: PubMed
  44. Eggert US, Mitchison TJ. Small molecule screening by imaging. Curr Opin Chem Biol. 2006 Jun; 10(3):232-7.
    View in: PubMed
  45. Ribbeck K, Groen AC, Santarella R, Bohnsack MT, Raemaekers T, Köcher T, Gentzel M, Görlich D, Wilm M, Carmeliet G, Mitchison TJ, Ellenberg J, Hoenger A, Mattaj IW. NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules. Mol Biol Cell. 2006 Jun; 17(6):2646-60.
    View in: PubMed
  46. Maliga Z, Mitchison TJ. Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol. BMC Chem Biol. 2006; 6:2.
    View in: PubMed
  47. De Wall SL, Painter C, Stone JD, Bandaranayake R, Wiley DC, Mitchison TJ, Stern LJ, DeDecker BS. Noble metals strip peptides from class II MHC proteins. Nat Chem Biol. 2006 Apr; 2(4):197-201.
    View in: PubMed
  48. Eggert US, Mitchison TJ, Field CM. Animal cytokinesis: from parts list to mechanisms. Annu Rev Biochem. 2006; 75:543-66.
    View in: PubMed
  49. Eggert US, Field CM, Mitchison TJ. Small molecules in an RNAi world. Mol Biosyst. 2006 Feb; 2(2):93-6.
    View in: PubMed
  50. Chang P, Coughlin M, Mitchison TJ. Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function. Nat Cell Biol. 2005 Nov; 7(11):1133-9.
    View in: PubMed
  51. Mahadevan L, Mitchison TJ. Cell biology: powerful curves. Nature. 2005 Jun 16; 435(7044):895-7.
    View in: PubMed
  52. Dorer RK, Zhong S, Tallarico JA, Wong WH, Mitchison TJ, Murray AW. A small-molecule inhibitor of Mps1 blocks the spindle-checkpoint response to a lack of tension on mitotic chromosomes. Curr Biol. 2005 Jun 7; 15(11):1070-6.
    View in: PubMed
  53. Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol. 2005 Jul; 1(2):112-9.
    View in: PubMed
  54. Charras GT, Yarrow JC, Horton MA, Mahadevan L, Mitchison TJ. Non-equilibration of hydrostatic pressure in blebbing cells. Nature. 2005 May 19; 435(7040):365-9.
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  55. Mitchison TJ. Mechanism and function of poleward flux in Xenopus extract meiotic spindles. Philos Trans R Soc Lond B Biol Sci. 2005 Mar 29; 360(1455):623-9.
    View in: PubMed
  56. Mitchison TJ, Maddox P, Gaetz J, Groen A, Shirasu M, Desai A, Salmon ED, Kapoor TM. Roles of polymerization dynamics, opposed motors, and a tensile element in governing the length of Xenopus extract meiotic spindles. Mol Biol Cell. 2005 Jun; 16(6):3064-76.
    View in: PubMed
  57. Yarrow JC, Totsukawa G, Charras GT, Mitchison TJ. Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor. Chem Biol. 2005 Mar; 12(3):385-95.
    View in: PubMed
  58. Perlman ZE, Mitchison TJ, Mayer TU. High-content screening and profiling of drug activity in an automated centrosome-duplication assay. Chembiochem. 2005 Jan; 6(1):145-51.
    View in: PubMed
  59. Mitchison TJ. Small-molecule screening and profiling by using automated microscopy. Chembiochem. 2005 Jan; 6(1):33-9.
    View in: PubMed
  60. Miyamoto DT, Perlman ZE, Burbank KS, Groen AC, Mitchison TJ. The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles. J Cell Biol. 2004 Dec 6; 167(5):813-8.
    View in: PubMed
  61. Chang P, Jacobson MK, Mitchison TJ. Poly(ADP-ribose) is required for spindle assembly and structure. Nature. 2004 Dec 2; 432(7017):645-9.
    View in: PubMed
  62. Ramamurthy B, Yengo CM, Straight AF, Mitchison TJ, Sweeney HL. Kinetic mechanism of blebbistatin inhibition of nonmuscle myosin IIb. Biochemistry. 2004 Nov 23; 43(46):14832-9.
    View in: PubMed
  63. Perlman ZE, Slack MD, Feng Y, Mitchison TJ, Wu LF, Altschuler SJ. Multidimensional drug profiling by automated microscopy. Science. 2004 Nov 12; 306(5699):1194-8.
    View in: PubMed
  64. Shirasu-Hiza M, Perlman ZE, Wittmann T, Karsenti E, Mitchison TJ. Eg5 causes elongation of meiotic spindles when flux-associated microtubule depolymerization is blocked. Curr Biol. 2004 Nov 9; 14(21):1941-5.
    View in: PubMed
  65. Groen AC, Cameron LA, Coughlin M, Miyamoto DT, Mitchison TJ, Ohi R. XRHAMM functions in ran-dependent microtubule nucleation and pole formation during anastral spindle assembly. Curr Biol. 2004 Oct 26; 14(20):1801-11.
    View in: PubMed
  66. Valentine MT, Perlman ZE, Mitchison TJ, Weitz DA. Mechanical properties of Xenopus egg cytoplasmic extracts. Biophys J. 2005 Jan; 88(1):680-9.
    View in: PubMed
  67. Straight AF, Field CM, Mitchison TJ. Anillin binds nonmuscle myosin II and regulates the contractile ring. Mol Biol Cell. 2005 Jan; 16(1):193-201.
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  68. Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale RD, Walczak CE, Wordeman L. A standardized kinesin nomenclature. J Cell Biol. 2004 Oct 11; 167(1):19-22.
    View in: PubMed
  69. Eggert US, Kiger AA, Richter C, Perlman ZE, Perrimon N, Mitchison TJ, Field CM. Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol. 2004 Dec; 2(12):e379.
    View in: PubMed
  70. Mitchison TJ, Maddox P, Groen A, Cameron L, Perlman Z, Ohi R, Desai A, Salmon ED, Kapoor TM. Bipolarization and poleward flux correlate during Xenopus extract spindle assembly. Mol Biol Cell. 2004 Dec; 15(12):5603-15.
    View in: PubMed
  71. Yarrow JC, Perlman ZE, Westwood NJ, Mitchison TJ. A high-throughput cell migration assay using scratch wound healing, a comparison of image-based readout methods. BMC Biotechnol. 2004 Sep 9; 4:21.
    View in: PubMed
  72. Salic A, Waters JC, Mitchison TJ. Vertebrate shugoshin links sister centromere cohesion and kinetochore microtubule stability in mitosis. Cell. 2004 Sep 3; 118(5):567-78.
    View in: PubMed
  73. Margalit DN, Romberg L, Mets RB, Hebert AM, Mitchison TJ, Kirschner MW, RayChaudhuri D. Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality. Proc Natl Acad Sci U S A. 2004 Aug 10; 101(32):11821-6.
    View in: PubMed
  74. Miller SC, Mitchison TJ. Synthesis and phenotypic screening of a Guanine-mimetic library. Chembiochem. 2004 Jul 5; 5(7):1010-2.
    View in: PubMed
  75. Venkatesh N, Feng Y, DeDecker B, Yacono P, Golan D, Mitchison T, McKeon F. Chemical genetics to identify NFAT inhibitors: potential of targeting calcium mobilization in immunosuppression. Proc Natl Acad Sci U S A. 2004 Jun 15; 101(24):8969-74.
    View in: PubMed
  76. Valentine MT, Perlman ZE, Gardel ML, Shin JH, Matsudaira P, Mitchison TJ, Weitz DA. Colloid surface chemistry critically affects multiple particle tracking measurements of biomaterials. Biophys J. 2004 Jun; 86(6):4004-14.
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  77. Carey KL, Westwood NJ, Mitchison TJ, Ward GE. A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7433-8.
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  78. Brieher WM, Coughlin M, Mitchison TJ. Fascin-mediated propulsion of Listeria monocytogenes independent of frequent nucleation by the Arp2/3 complex. J Cell Biol. 2004 Apr 26; 165(2):233-42.
    View in: PubMed
  79. Ohi R, Sapra T, Howard J, Mitchison TJ. Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation. Mol Biol Cell. 2004 Jun; 15(6):2895-906.
    View in: PubMed
  80. Corcoran LJ, Mitchison TJ, Liu Q. A novel action of histone deacetylase inhibitors in a protein aggresome disease model. Curr Biol. 2004 Mar 23; 14(6):488-92.
    View in: PubMed
  81. Tirnauer JS, Salmon ED, Mitchison TJ. Microtubule plus-end dynamics in Xenopus egg extract spindles. Mol Biol Cell. 2004 Apr; 15(4):1776-84.
    View in: PubMed
  82. Romberg L, Mitchison TJ. Rate-limiting guanosine 5'-triphosphate hydrolysis during nucleotide turnover by FtsZ, a prokaryotic tubulin homologue involved in bacterial cell division. Biochemistry. 2004 Jan 13; 43(1):282-8.
    View in: PubMed
  83. Limouze J, Straight AF, Mitchison T, Sellers JR. Specificity of blebbistatin, an inhibitor of myosin II. J Muscle Res Cell Motil. 2004; 25(4-5):337-41.
    View in: PubMed
  84. Vrabioiu AM, Gerber SA, Gygi SP, Field CM, Mitchison TJ. The majority of the Saccharomyces cerevisiae septin complexes do not exchange guanine nucleotides. J Biol Chem. 2004 Jan 23; 279(4):3111-8.
    View in: PubMed
  85. Canman JC, Cameron LA, Maddox PS, Straight A, Tirnauer JS, Mitchison TJ, Fang G, Kapoor TM, Salmon ED. Determining the position of the cell division plane. Nature. 2003 Aug 28; 424(6952):1074-8.
    View in: PubMed
  86. Maddox P, Straight A, Coughlin P, Mitchison TJ, Salmon ED. Direct observation of microtubule dynamics at kinetochores in Xenopus extract spindles: implications for spindle mechanics. J Cell Biol. 2003 Aug 4; 162(3):377-82.
    View in: PubMed
  87. Ohi R, Coughlin ML, Lane WS, Mitchison TJ. An inner centromere protein that stimulates the microtubule depolymerizing activity of a KinI kinesin. Dev Cell. 2003 Aug; 5(2):309-21.
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  88. Xu J, Wang F, Van Keymeulen A, Herzmark P, Straight A, Kelly K, Takuwa Y, Sugimoto N, Mitchison T, Bourne HR. Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell. 2003 Jul 25; 114(2):201-14.
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  89. Zhai Q, Wang J, Kim A, Liu Q, Watts R, Hoopfer E, Mitchison T, Luo L, He Z. Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration. Neuron. 2003 Jul 17; 39(2):217-25.
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  90. Yarrow JC, Lechler T, Li R, Mitchison TJ. Rapid de-localization of actin leading edge components with BDM treatment. BMC Cell Biol. 2003 Jun 3; 4:5.
    View in: PubMed
  91. Yarrow JC, Feng Y, Perlman ZE, Kirchhausen T, Mitchison TJ. Phenotypic screening of small molecule libraries by high throughput cell imaging. Comb Chem High Throughput Screen. 2003 Jun; 6(4):279-86.
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  92. Feng Y, Yu S, Lasell TK, Jadhav AP, Macia E, Chardin P, Melancon P, Roth M, Mitchison T, Kirchhausen T. Exo1: a new chemical inhibitor of the exocytic pathway. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6469-74.
    View in: PubMed
  93. Shirasu-Hiza M, Coughlin P, Mitchison T. Identification of XMAP215 as a microtubule-destabilizing factor in Xenopus egg extract by biochemical purification. J Cell Biol. 2003 Apr 28; 161(2):349-58.
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  94. Straight AF, Cheung A, Limouze J, Chen I, Westwood NJ, Sellers JR, Mitchison TJ. Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor. Science. 2003 Mar 14; 299(5613):1743-7.
    View in: PubMed
  95. McGrath JL, Eungdamrong NJ, Fisher CI, Peng F, Mahadevan L, Mitchison TJ, Kuo SC. The force-velocity relationship for the actin-based motility of Listeria monocytogenes. Curr Biol. 2003 Feb 18; 13(4):329-32.
    View in: PubMed
  96. Miyamoto DT, Perlman ZE, Mitchison TJ, Shirasu-Hiza M. Dynamics of the mitotic spindle--potential therapeutic targets. Prog Cell Cycle Res. 2003; 5:349-60.
    View in: PubMed
  97. Kinoshita M, Field CM, Coughlin ML, Straight AF, Mitchison TJ. Self- and actin-templated assembly of Mammalian septins. Dev Cell. 2002 Dec; 3(6):791-802.
    View in: PubMed
  98. Macara IG, Baldarelli R, Field CM, Glotzer M, Hayashi Y, Hsu SC, Kennedy MB, Kinoshita M, Longtine M, Low C, Maltais LJ, McKenzie L, Mitchison TJ, Nishikawa T, Noda M, Petty EM, Peifer M, Pringle JR, Robinson PJ, Roth D, Russell SE, Stuhlmann H, Tanaka M, Tanaka T, Trimble WS, Ware J, Zeleznik-Le NJ, Zieger B. Mammalian septins nomenclature. Mol Biol Cell. 2002 Dec; 13(12):4111-3.
    View in: PubMed
  99. Tirnauer JS, Canman JC, Salmon ED, Mitchison TJ. EB1 targets to kinetochores with attached, polymerizing microtubules. Mol Biol Cell. 2002 Dec; 13(12):4308-16.
    View in: PubMed
  100. Peterson JR, Mitchison TJ. Small molecules, big impact: a history of chemical inhibitors and the cytoskeleton. Chem Biol. 2002 Dec; 9(12):1275-85.
    View in: PubMed
  101. Mitchison TJ, Field CM. Cytoskeleton: what does GTP do for septins? Curr Biol. 2002 Nov 19; 12(22):R788-90.
    View in: PubMed
  102. Walczak CE, Gan EC, Desai A, Mitchison TJ, Kline-Smith SL. The microtubule-destabilizing kinesin XKCM1 is required for chromosome positioning during spindle assembly. Curr Biol. 2002 Oct 29; 12(21):1885-9.
    View in: PubMed
  103. Tirnauer JS, Grego S, Salmon ED, Mitchison TJ. EB1-microtubule interactions in Xenopus egg extracts: role of EB1 in microtubule stabilization and mechanisms of targeting to microtubules. Mol Biol Cell. 2002 Oct; 13(10):3614-26.
    View in: PubMed
  104. Maddox P, Desai A, Oegema K, Mitchison TJ, Salmon ED. Poleward microtubule flux is a major component of spindle dynamics and anaphase a in mitotic Drosophila embryos. Curr Biol. 2002 Oct 1; 12(19):1670-4.
    View in: PubMed
  105. Maliga Z, Kapoor TM, Mitchison TJ. Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5. Chem Biol. 2002 Sep; 9(9):989-96.
    View in: PubMed
  106. Watanabe N, Mitchison TJ. Single-molecule speckle analysis of actin filament turnover in lamellipodia. Science. 2002 Feb 8; 295(5557):1083-6.
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  107. Mitchison TJ. Probing cell division with "chemical genetics". Harvey Lect. 2002-2003; 98:19-40.
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  108. Cheung A, Dantzig JA, Hollingworth S, Baylor SM, Goldman YE, Mitchison TJ, Straight AF. A small-molecule inhibitor of skeletal muscle myosin II. Nat Cell Biol. 2002 Jan; 4(1):83-8.
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  109. Kapoor TM, Mitchison TJ. Eg5 is static in bipolar spindles relative to tubulin: evidence for a static spindle matrix. J Cell Biol. 2001 Sep 17; 154(6):1125-33.
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  110. Peterson JR, Lokey RS, Mitchison TJ, Kirschner MW. A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proc Natl Acad Sci U S A. 2001 Sep 11; 98(19):10624-9.
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  111. Mitchison TJ. Psychosine, cytokinesis, and orphan receptors. Unexpected connections. J Cell Biol. 2001 Apr 16; 153(2):F1-3.
    View in: PubMed
  112. Degterev A, Lugovskoy A, Cardone M, Mulley B, Wagner G, Mitchison T, Yuan J. Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL. Nat Cell Biol. 2001 Feb; 3(2):173-82.
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  113. Mitchison TJ, Salmon ED. Mitosis: a history of division. Nat Cell Biol. 2001 Jan; 3(1):E17-21.
    View in: PubMed
  114. Kapoor TM, Mayer TU, Coughlin ML, Mitchison TJ. Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5. J Cell Biol. 2000 Sep 4; 150(5):975-88.
    View in: PubMed
  115. Oegema K, Savoian MS, Mitchison TJ, Field CM. Functional analysis of a human homologue of the Drosophila actin binding protein anillin suggests a role in cytokinesis. J Cell Biol. 2000 Aug 7; 150(3):539-52.
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  116. Haggarty SJ, Mayer TU, Miyamoto DT, Fathi R, King RW, Mitchison TJ, Schreiber SL. Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis. Chem Biol. 2000 Apr; 7(4):275-86.
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  117. Taunton J, Rowning BA, Coughlin ML, Wu M, Moon RT, Mitchison TJ, Larabell CA. Actin-dependent propulsion of endosomes and lysosomes by recruitment of N-WASP. J Cell Biol. 2000 Feb 7; 148(3):519-30.
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  118. Kirschner M, Gerhart J, Mitchison T. Molecular "vitalism". Cell. 2000 Jan 7; 100(1):79-88.
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  119. Mallavarapu A, Sawin K, Mitchison T. A switch in microtubule dynamics at the onset of anaphase B in the mitotic spindle of Schizosaccharomyces pombe. Curr Biol. 1999 Dec 2; 9(23):1423-6.
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  120. Mayer TU, Kapoor TM, Haggarty SJ, King RW, Schreiber SL, Mitchison TJ. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science. 1999 Oct 29; 286(5441):971-4.
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  121. Maddox P, Desai A, Salmon ED, Mitchison TJ, Oogema K, Kapoor T, Matsumoto B, Inoué S. Dynamic confocal imaging of mitochondria in swimming Tetrahymena and of microtubule poleward flux in Xenopus extract spindles. Biol Bull. 1999 Oct; 197(2):263-5.
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  122. Mallavarapu A, Mitchison T. Regulated actin cytoskeleton assembly at filopodium tips controls their extension and retraction. J Cell Biol. 1999 Sep 6; 146(5):1097-106.
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  123. Kapoor TM, Mitchison TJ. Allele-specific activators and inhibitors for kinesin. Proc Natl Acad Sci U S A. 1999 Aug 3; 96(16):9106-11.
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  124. Weiner OD, Servant G, Welch MD, Mitchison TJ, Sedat JW, Bourne HR. Spatial control of actin polymerization during neutrophil chemotaxis. Nat Cell Biol. 1999 Jun; 1(2):75-81.
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  125. Oegema K, Wiese C, Martin OC, Milligan RA, Iwamatsu A, Mitchison TJ, Zheng Y. Characterization of two related Drosophila gamma-tubulin complexes that differ in their ability to nucleate microtubules. J Cell Biol. 1999 Feb 22; 144(4):721-33.
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  126. Sharp DJ, McDonald KL, Brown HM, Matthies HJ, Walczak C, Vale RD, Mitchison TJ, Scholey JM. The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles. J Cell Biol. 1999 Jan 11; 144(1):125-38.
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  127. Desai A, Verma S, Mitchison TJ, Walczak CE. Kin I kinesins are microtubule-destabilizing enzymes. Cell. 1999 Jan 8; 96(1):69-78.
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  128. Desai A, Murray A, Mitchison TJ, Walczak CE. The use of Xenopus egg extracts to study mitotic spindle assembly and function in vitro. Methods Cell Biol. 1999; 61:385-412.
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  129. Frazier JA, Wong ML, Longtine MS, Pringle JR, Mann M, Mitchison TJ, Field C. Polymerization of purified yeast septins: evidence that organized filament arrays may not be required for septin function. J Cell Biol. 1998 Nov 2; 143(3):737-49.
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  130. Yoshihara HA, Chiellini G, Mitchison TJ, Scanlan TS. An efficient substitution reaction for the preparation of thyroid hormone analogues. Bioorg Med Chem. 1998 Aug; 6(8):1179-83.
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  131. Welch MD, Rosenblatt J, Skoble J, Portnoy DA, Mitchison TJ. Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation. Science. 1998 Jul 3; 281(5373):105-8.
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  132. Walczak CE, Vernos I, Mitchison TJ, Karsenti E, Heald R. A model for the proposed roles of different microtubule-based motor proteins in establishing spindle bipolarity. Curr Biol. 1998 Jul 30-Aug 13; 8(16):903-13.
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  133. Desai A, Mitchison TJ. Tubulin and FtsZ structures: functional and therapeutic implications. Bioessays. 1998 Jul; 20(7):523-7.
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  134. Rosenblatt J, Mitchison TJ. Actin, cofilin and cognition. Nature. 1998 Jun 25; 393(6687):739-40.
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  135. Desai A, Maddox PS, Mitchison TJ, Salmon ED. Anaphase A chromosome movement and poleward spindle microtubule flux occur At similar rates in Xenopus extract spindles. J Cell Biol. 1998 May 4; 141(3):703-13.
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  136. Zheng Y, Wong ML, Alberts B, Mitchison T. Purification and assay of gamma tubulin ring complex. Methods Enzymol. 1998; 298:218-28.
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  137. Welch MD, Mitchison TJ. Purification and assay of the platelet Arp2/3 complex. Methods Enzymol. 1998; 298:52-61.
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  138. Field CM, Oegema K, Zheng Y, Mitchison TJ, Walczak CE. Purification of cytoskeletal proteins using peptide antibodies. Methods Enzymol. 1998; 298:525-41.
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  139. Oegema K, Desai A, Wong ML, Mitchison TJ, Field CM. Purification and assay of a septin complex from Drosophila embryos. Methods Enzymol. 1998; 298:279-95.
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  140. Mitchison TJ, Sawin KE, Theriot JA, Gee K, Mallavarapu A. Caged fluorescent probes. Methods Enzymol. 1998; 291:63-78.
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  141. Desai A, Deacon HW, Walczak CE, Mitchison TJ. A method that allows the assembly of kinetochore components onto chromosomes condensed in clarified Xenopus egg extracts. Proc Natl Acad Sci U S A. 1997 Nov 11; 94(23):12378-83.
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  142. Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. J Cell Biol. 1997 Jul 28; 138(2):375-84.
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  143. Oegema K, Mitchison TJ. Rappaport rules: cleavage furrow induction in animal cells. Proc Natl Acad Sci U S A. 1997 May 13; 94(10):4817-20.
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  144. Rosenblatt J, Agnew BJ, Abe H, Bamburg JR, Mitchison TJ. Xenopus actin depolymerizing factor/cofilin (XAC) is responsible for the turnover of actin filaments in Listeria monocytogenes tails. J Cell Biol. 1997 Mar 24; 136(6):1323-32.
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  145. Cramer LP, Siebert M, Mitchison TJ. Identification of novel graded polarity actin filament bundles in locomoting heart fibroblasts: implications for the generation of motile force. J Cell Biol. 1997 Mar 24; 136(6):1287-305.
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  146. Walczak CE, Verma S, Mitchison TJ. XCTK2: a kinesin-related protein that promotes mitotic spindle assembly in Xenopus laevis egg extracts. J Cell Biol. 1997 Feb 24; 136(4):859-70.
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  147. Welch MD, Mallavarapu A, Rosenblatt J, Mitchison TJ. Actin dynamics in vivo. Curr Opin Cell Biol. 1997 Feb; 9(1):54-61.
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  148. Welch MD, Iwamatsu A, Mitchison TJ. Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes. Nature. 1997 Jan 16; 385(6613):265-9.
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  149. Cramer LP, Mitchison TJ. Investigation of the mechanism of retraction of the cell margin and rearward flow of nodules during mitotic cell rounding. Mol Biol Cell. 1997 Jan; 8(1):109-19.
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  150. Desai A, Mitchison TJ. Microtubule polymerization dynamics. Annu Rev Cell Dev Biol. 1997; 13:83-117.
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  151. Waters JC, Mitchison TJ, Rieder CL, Salmon ED. The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do work. Mol Biol Cell. 1996 Oct; 7(10):1547-58.
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  152. Walczak CE, Mitchison TJ. Kinesin-related proteins at mitotic spindle poles: function and regulation. Cell. 1996 Jun 28; 85(7):943-6.
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  153. Belmont L, Mitchison T, Deacon HW. Catastrophic revelations about Op18/stathmin. Trends Biochem Sci. 1996 Jun; 21(6):197-8.
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  154. Field CM, al-Awar O, Rosenblatt J, Wong ML, Alberts B, Mitchison TJ. A purified Drosophila septin complex forms filaments and exhibits GTPase activity. J Cell Biol. 1996 May; 133(3):605-16.
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  155. Belmont LD, Mitchison TJ. Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules. Cell. 1996 Feb 23; 84(4):623-31.
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  156. Mitchison TJ, Cramer LP. Actin-based cell motility and cell locomotion. Cell. 1996 Feb 9; 84(3):371-9.
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  157. Walczak CE, Mitchison TJ, Desai A. XKCM1: a Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly. Cell. 1996 Jan 12; 84(1):37-47.
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  158. Zheng Y, Wong ML, Alberts B, Mitchison T. Nucleation of microtubule assembly by a gamma-tubulin-containing ring complex. Nature. 1995 Dec 7; 378(6557):578-83.
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  159. Cramer LP, Mitchison TJ. Myosin is involved in postmitotic cell spreading. J Cell Biol. 1995 Oct; 131(1):179-89.
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  160. Mitchison TJ. Evolution of a dynamic cytoskeleton. Philos Trans R Soc Lond B Biol Sci. 1995 Sep 29; 349(1329):299-304.
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  161. Sawin KE, Mitchison TJ. Mutations in the kinesin-like protein Eg5 disrupting localization to the mitotic spindle. Proc Natl Acad Sci U S A. 1995 May 9; 92(10):4289-93.
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  162. Rosenblatt J, Peluso P, Mitchison TJ. The bulk of unpolymerized actin in Xenopus egg extracts is ATP-bound. Mol Biol Cell. 1995 Feb; 6(2):227-36.
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  163. Wordeman L, Mitchison TJ. Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis. J Cell Biol. 1995 Jan; 128(1-2):95-104.
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  164. Desai A, Mitchison TJ. A new role for motor proteins as couplers to depolymerizing microtubules. J Cell Biol. 1995 Jan; 128(1-2):1-4.
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  165. Hirano T, Mitchison TJ. A heterodimeric coiled-coil protein required for mitotic chromosome condensation in vitro. Cell. 1994 Nov 4; 79(3):449-58.
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  166. Mitchison TJ. Towards a pharmacological genetics. Chem Biol. 1994 Sep; 1(1):3-6.
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  167. Theriot JA, Rosenblatt J, Portnoy DA, Goldschmidt-Clermont PJ, Mitchison TJ. Involvement of profilin in the actin-based motility of L. monocytogenes in cells and in cell-free extracts. Cell. 1994 Feb 11; 76(3):505-17.
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  168. Cramer LP, Mitchison TJ, Theriot JA. Actin-dependent motile forces and cell motility. Curr Opin Cell Biol. 1994 Feb; 6(1):82-6.
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  169. Sawin KE, Mitchison TJ. Microtubule flux in mitosis is independent of chromosomes, centrosomes, and antiparallel microtubules. Mol Biol Cell. 1994 Feb; 5(2):217-26.
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  170. Murray AW, Mitchison TJ. Mitosis. Kinetochores pass the IQ test. Curr Biol. 1994 Jan 1; 4(1):38-41.
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  171. Theriot JA, Mitchison TJ. The three faces of profilin. Cell. 1993 Dec 3; 75(5):835-8.
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  172. Mitchison TJ. Localization of an exchangeable GTP binding site at the plus end of microtubules. Science. 1993 Aug 20; 261(5124):1044-7.
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  173. Cramer L, Mitchison TJ. Moving and stationary actin filaments are involved in spreading of postmitotic PtK2 cells. J Cell Biol. 1993 Aug; 122(4):833-43.
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  174. Hirano T, Mitchison TJ. Topoisomerase II does not play a scaffolding role in the organization of mitotic chromosomes assembled in Xenopus egg extracts. J Cell Biol. 1993 Feb; 120(3):601-12.
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  175. Mitchison TJ. Compare and contrast actin filaments and microtubules. Mol Biol Cell. 1992 Dec; 3(12):1309-15.
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  176. Mitchison TJ, Salmon ED. Poleward kinetochore fiber movement occurs during both metaphase and anaphase-A in newt lung cell mitosis. J Cell Biol. 1992 Nov; 119(3):569-82.
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  177. Sawin KE, LeGuellec K, Philippe M, Mitchison TJ. Mitotic spindle organization by a plus-end-directed microtubule motor. Nature. 1992 Oct 8; 359(6395):540-3.
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  178. Hyman AA, Middleton K, Centola M, Mitchison TJ, Carbon J. Microtubule-motor activity of a yeast centromere-binding protein complex. Nature. 1992 Oct 8; 359(6395):533-6.
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  179. Hyman AA, Salser S, Drechsel DN, Unwin N, Mitchison TJ. Role of GTP hydrolysis in microtubule dynamics: information from a slowly hydrolyzable analogue, GMPCPP. Mol Biol Cell. 1992 Oct; 3(10):1155-67.
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  180. Theriot JA, Mitchison TJ. Comparison of actin and cell surface dynamics in motile fibroblasts. J Cell Biol. 1992 Oct; 119(2):367-77.
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  181. Symons MH, Mitchison TJ. A GTPase controls cell-substrate adhesion in Xenopus XTC fibroblasts. J Cell Biol. 1992 Sep; 118(5):1235-44.
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  182. Mitchison TJ. Self-organization of polymer-motor systems in the cytoskeleton. Philos Trans R Soc Lond B Biol Sci. 1992 Apr 29; 336(1276):99-106.
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  183. Sawin KE, Mitchison TJ, Wordeman LG. Evidence for kinesin-related proteins in the mitotic apparatus using peptide antibodies. J Cell Sci. 1992 Feb; 101 ( Pt 2):303-13.
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  184. Mitchison TJ. Actin based motility on retraction fibers in mitotic PtK2 cells. Cell Motil Cytoskeleton. 1992; 22(2):135-51.
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  185. Hirano T, Mitchison TJ. Cell cycle control of higher-order chromatin assembly around naked DNA in vitro. J Cell Biol. 1991 Dec; 115(6):1479-89.
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  186. Reinsch SS, Mitchison TJ, Kirschner M. Microtubule polymer assembly and transport during axonal elongation. J Cell Biol. 1991 Oct; 115(2):365-79.
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  187. Symons MH, Mitchison TJ. Control of actin polymerization in live and permeabilized fibroblasts. J Cell Biol. 1991 Aug; 114(3):503-13.
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  188. Theriot JA, Mitchison TJ. Actin microfilament dynamics in locomoting cells. Nature. 1991 Jul 11; 352(6331):126-31.
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  189. Wordeman L, Steuer ER, Sheetz MP, Mitchison T. Chemical subdomains within the kinetochore domain of isolated CHO mitotic chromosomes. J Cell Biol. 1991 Jul; 114(2):285-94.
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  190. Hyman AA, Mitchison TJ. Two different microtubule-based motor activities with opposite polarities in kinetochores. Nature. 1991 May 16; 351(6323):206-11.
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  191. Sawin KE, Mitchison TJ. Mitotic spindle assembly by two different pathways in vitro. J Cell Biol. 1991 Mar; 112(5):925-40.
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  192. Sawin KE, Mitchison TJ. Poleward microtubule flux mitotic spindles assembled in vitro. J Cell Biol. 1991 Mar; 112(5):941-54.
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  193. Hyman AA, Mitchison TJ. Regulation of the direction of chromosome movement. Cold Spring Harb Symp Quant Biol. 1991; 56:745-50.
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  194. Mitchison TJ. Mitosis. The kinetochore in captivity. Nature. 1990 Nov 1; 348(6296):14-5.
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  195. Belmont LD, Hyman AA, Sawin KE, Mitchison TJ. Real-time visualization of cell cycle-dependent changes in microtubule dynamics in cytoplasmic extracts. Cell. 1990 Aug 10; 62(3):579-89.
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  196. Sawin K, Mitchison T. Cell biology. Motoring in the spindle. Nature. 1990 May 3; 345(6270):22-3.
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  197. Hyman AA, Mitchison TJ. Modulation of microtubule stability by kinetochores in vitro. J Cell Biol. 1990 May; 110(5):1607-16.
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  198. Mitchison TJ, Sawin KE. Tubulin flux in the mitotic spindle: where does it come from, where is it going? Cell Motil Cytoskeleton. 1990; 16(2):93-8.
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  199. Mitchison TJ. Polewards microtubule flux in the mitotic spindle: evidence from photoactivation of fluorescence. J Cell Biol. 1989 Aug; 109(2):637-52.
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  200. Chain BM, Mitchison NA, Mitchison TJ, Davies DH, Marcinkiewicz J. Antigen processing: current issues, exceptional cases (Thy 1 alloantigen, MHC class-II-restricted cytolytic T cells), and implications for vaccine development. J Autoimmun. 1989 Jun; 2 Suppl:45-53.
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  201. Mitchison TJ. Mitosis: basic concepts. Curr Opin Cell Biol. 1989 Feb; 1(1):67-74.
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  202. Mitchison T, Kirschner M. Cytoskeletal dynamics and nerve growth. Neuron. 1988 Nov; 1(9):761-72.
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  203. Kellogg DR, Mitchison TJ, Alberts BM. Behaviour of microtubules and actin filaments in living Drosophila embryos. Development. 1988 Aug; 103(4):675-86.
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  204. Koshland DE, Mitchison TJ, Kirschner MW. Polewards chromosome movement driven by microtubule depolymerization in vitro. Nature. 1988 Feb 11; 331(6156):499-504.
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  205. Mitchison TJ. Microtubule dynamics and kinetochore function in mitosis. Annu Rev Cell Biol. 1988; 4:527-49.
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  206. Mitchison TJ, Kirschner MW. Some thoughts on the partitioning of tubulin between monomer and polymer under conditions of dynamic instability. Cell Biophys. 1987 Dec; 11:35-55.
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  207. Kirschner MW, Mitchison T. Microtubule dynamics. Nature. 1986 Dec 18-31; 324(6098):621.
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  208. Mitchison T, Evans L, Schulze E, Kirschner M. Sites of microtubule assembly and disassembly in the mitotic spindle. Cell. 1986 May 23; 45(4):515-27.
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  209. Kirschner M, Mitchison T. Beyond self-assembly: from microtubules to morphogenesis. Cell. 1986 May 9; 45(3):329-42.
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  210. Kristofferson D, Mitchison T, Kirschner M. Direct observation of steady-state microtubule dynamics. J Cell Biol. 1986 Mar; 102(3):1007-19.
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  211. Mitchison TJ, Kirschner MW. Isolation of mammalian centrosomes. Methods Enzymol. 1986; 134:261-8.
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  212. Mitchison TJ. The role of microtubule polarity in the movement of kinesin and kinetochores. J Cell Sci Suppl. 1986; 5:121-8.
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  213. Vale RD, Schnapp BJ, Mitchison T, Steuer E, Reese TS, Sheetz MP. Different axoplasmic proteins generate movement in opposite directions along microtubules in vitro. Cell. 1985 Dec; 43(3 Pt 2):623-32.
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  214. Mitchison TJ, Kirschner MW. Properties of the kinetochore in vitro. II. Microtubule capture and ATP-dependent translocation. J Cell Biol. 1985 Sep; 101(3):766-77.
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  215. Mitchison TJ, Kirschner MW. Properties of the kinetochore in vitro. I. Microtubule nucleation and tubulin binding. J Cell Biol. 1985 Sep; 101(3):755-65.
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  216. Evans L, Mitchison T, Kirschner M. Influence of the centrosome on the structure of nucleated microtubules. J Cell Biol. 1985 Apr; 100(4):1185-91.
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  217. Leslie RJ, Saxton WM, Mitchison TJ, Neighbors B, Salmon ED, McIntosh JR. Assembly properties of fluorescein-labeled tubulin in vitro before and after fluorescence bleaching. J Cell Biol. 1984 Dec; 99(6):2146-56.
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  218. Mitchison T, Kirschner M. Microtubule assembly nucleated by isolated centrosomes. Nature. 1984 Nov 15-21; 312(5991):232-7.
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  219. Mitchison T, Kirschner M. Dynamic instability of microtubule growth. Nature. 1984 Nov 15-21; 312(5991):237-42.
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  220. Karsenti E, Kobayashi S, Mitchison T, Kirschner M. Role of the centrosome in organizing the interphase microtubule array: properties of cytoplasts containing or lacking centrosomes. J Cell Biol. 1984 May; 98(5):1763-76.
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  221. Calarco-Gillam PD, Siebert MC, Hubble R, Mitchison T, Kirschner M. Centrosome development in early mouse embryos as defined by an autoantibody against pericentriolar material. Cell. 1983 Dec; 35(3 Pt 2):621-9.
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  222. Botchan M, Stringer J, Mitchison T, Sambrook J. Integration and excision of SV40 DNA from the chromosome of a transformed cell. Cell. 1980 May; 20(1):143-52.
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