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Last Name
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Timothy J. Mitchison, Ph.D.

TitleHasib Sabbagh Professor of Systems Biology
InstitutionHarvard Medical School
DepartmentSystems Biology
AddressHarvard Medical School
Alpert 536, Systems Biology
200 Longwood Ave
Boston MA 02115
Phone617/432-3805
Fax617/432-3702
Other Positions
TitleDeputy Chairman of the Department of Systems Biology
InstitutionHarvard Medical School
DepartmentSystems Biology


 Mentoring 
 completed student projects
Elucidation of Mechanism of Action of Cell Motility Inhibitors in a Wound-Healing Assay
Summer, 05/22/00 - 08/01/00
Using Small Molecules to Perturb and Study Cytoskeletal Function
Summer, 06/01/99 - 08/31/99

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Coughlin M, Groen AC, Mitchison TJ. Electron microscopy of microtubule cytoskeleton assembly in vitro. Methods Mol Biol. 2014; 1117:259-71.
    View in: PubMed
  2. Prentice-Mott HV, Chang CH, Mahadevan L, Mitchison TJ, Irimia D, Shah JV. Biased migration of confined neutrophil-like cells in asymmetric hydraulic environments. Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):21006-11.
    View in: PubMed
  3. Loose M, Mitchison TJ. The bacterial cell division proteins FtsA and FtsZ self-organize into dynamic cytoskeletal patterns. Nat Cell Biol. 2014 Jan; 16(1):38-46.
    View in: PubMed
  4. Wang S, Romano FB, Field CM, Mitchison TJ, Rapoport TA. Multiple mechanisms determine ER network morphology during the cell cycle in Xenopus egg extracts. J Cell Biol. 2013 Dec 9; 203(5):801-14.
    View in: PubMed
  5. Mitchison TJ. A question of taste. Mol Biol Cell. 2013 Nov; 24(21):3278-80.
    View in: PubMed
  6. Zidovska A, Weitz DA, Mitchison TJ. Micron-scale coherence in interphase chromatin dynamics. Proc Natl Acad Sci U S A. 2013 Sep 24; 110(39):15555-60.
    View in: PubMed
  7. Barkauskaite E, Brassington A, Tan ES, Warwicker J, Dunstan MS, Banos B, Lafite P, Ahel M, Mitchison TJ, Ahel I, Leys D. Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities. Nat Commun. 2013 Aug 6; 4:2164.
    View in: PubMed
  8. Tang Y, Xie T, Florian S, Moerke N, Shamu C, Benes C, Mitchison TJ. Differential determinants of cancer cell insensitivity to antimitotic drugs discriminated by a one-step cell imaging assay. J Biomol Screen. 2013 Oct; 18(9):1062-71.
    View in: PubMed
  9. Choi PJ, Mitchison TJ. Imaging burst kinetics and spatial coordination during serial killing by single natural killer cells. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6488-93.
    View in: PubMed
  10. Mitchison TJ, Nguyen P, Coughlin M, Groen AC. Self-organization of stabilized microtubules by both spindle and midzone mechanisms in Xenopus egg cytosol. Mol Biol Cell. 2013 May; 24(10):1559-73.
    View in: PubMed
  11. Kueh HY, Niethammer P, Mitchison TJ. Maintenance of mitochondrial oxygen homeostasis by cosubstrate compensation. Biophys J. 2013 Mar 19; 104(6):1338-48.
    View in: PubMed
  12. Petry S, Groen AC, Ishihara K, Mitchison TJ, Vale RD. Branching Microtubule Nucleation in Xenopus Egg Extracts Mediated by Augmin and TPX2. Cell. 2013 Feb 14; 152(4):768-77.
    View in: PubMed
  13. Thurber GM, Yang KS, Reiner T, Kohler RH, Sorger P, Mitchison T, Weissleder R. Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo. Nat Commun. 2013; 4:1504.
    View in: PubMed
  14. Vale RD, DeRisi J, Phillips R, Mullins RD, Waterman C, Mitchison TJ. Graduate education. Interdisciplinary graduate training in teaching labs. Science. 2012 Dec 21; 338(6114):1542-3.
    View in: PubMed
  15. Maiuri P, Terriac E, Paul-Gilloteaux P, Vignaud T, McNally K, Onuffer J, Thorn K, Nguyen PA, Georgoulia N, Soong D, Jayo A, Beil N, Beneke J, Lim JC, Sim CP, Chu YS, Jiménez-Dalmaroni A, Joanny JF, Thiery JP, Erfle H, Parsons M, Mitchison TJ, Lim WA, Lennon-Duménil AM, Piel M, Théry M. The first World Cell Race. Curr Biol. 2012 Sep 11; 22(17):R673-5.
    View in: PubMed
  16. Mitchison T, Wühr M, Nguyen P, Ishihara K, Groen A, Field CM. Growth, interaction, and positioning of microtubule asters in extremely large vertebrate embryo cells. Cytoskeleton (Hoboken). 2012 Oct; 69(10):738-50.
    View in: PubMed
  17. Kim S, Peshkin L, Mitchison TJ. Vascular disrupting agent drug classes differ in effects on the cytoskeleton. PLoS One. 2012; 7(7):e40177.
    View in: PubMed
  18. Zhang X, Wang W, Bedigian AV, Coughlin ML, Mitchison TJ, Eggert US. Dopamine receptor D3 regulates endocytic sorting by a Prazosin-sensitive interaction with the coatomer COPI. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12485-90.
    View in: PubMed
  19. Tan ES, Krukenberg KA, Mitchison TJ. Large-scale preparation and characterization of poly(ADP-ribose) and defined length polymers. Anal Biochem. 2012 Sep 15; 428(2):126-36.
    View in: PubMed
  20. Dumont S, Salmon ED, Mitchison TJ. Deformations within moving kinetochores reveal different sites of active and passive force generation. Science. 2012 Jul 20; 337(6092):355-8.
    View in: PubMed
  21. Hu CK, Ozlü N, Coughlin M, Steen JJ, Mitchison TJ. Plk1 negatively regulates PRC1 to prevent premature midzone formation before cytokinesis. Mol Biol Cell. 2012 Jul; 23(14):2702-11.
    View in: PubMed
  22. Nguyen PA, Ishihara K, Wühr M, Mitchison TJ. Pronuclear migration: no attachment? No union, but a futile cycle! Curr Biol. 2012 May 22; 22(10):R409-11.
    View in: PubMed
  23. Hu CK, Coughlin M, Mitchison TJ. Midbody assembly and its regulation during cytokinesis. Mol Biol Cell. 2012 Mar; 23(6):1024-34.
    View in: PubMed
  24. Mitchison TJ. The proliferation rate paradox in antimitotic chemotherapy. Mol Biol Cell. 2012 Jan; 23(1):1-6.
    View in: PubMed
  25. Orth JD, Loewer A, Lahav G, Mitchison TJ. Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction. Mol Biol Cell. 2012 Feb; 23(4):567-76.
    View in: PubMed
  26. Kwiatkowski N, Deng X, Wang J, Tan L, Villa F, Santaguida S, Huang HC, Mitchison T, Musacchio A, Gray N. Selective aurora kinase inhibitors identified using a taxol-induced checkpoint sensitivity screen. ACS Chem Biol. 2012 Jan 20; 7(1):185-96.
    View in: PubMed
  27. Akhtar A, Fuchs E, Mitchison T, Shaw RJ, St Johnston D, Strasser A, Taylor S, Walczak C, Zerial M. A decade of molecular cell biology: achievements and challenges. Nat Rev Mol Cell Biol. 2011 Oct; 12(10):669-74.
    View in: PubMed
  28. Groen AC, Coughlin M, Mitchison TJ. Microtubule assembly in meiotic extract requires glycogen. Mol Biol Cell. 2011 Sep; 22(17):3139-51.
    View in: PubMed
  29. Orth JD, Kohler RH, Foijer F, Sorger PK, Weissleder R, Mitchison TJ. Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics. Cancer Res. 2011 Jul 1; 71(13):4608-16.
    View in: PubMed
  30. Tang Y, Orth JD, Xie T, Mitchison TJ. Rapid induction of apoptosis during Kinesin-5 inhibitor-induced mitotic arrest in HL60 cells. Cancer Lett. 2011 Nov 1; 310(1):15-24.
    View in: PubMed
  31. Garner EC, Bernard R, Wang W, Zhuang X, Rudner DZ, Mitchison T. Coupled, circumferential motions of the cell wall synthesis machinery and MreB filaments in B. subtilis. Science. 2011 Jul 8; 333(6039):222-5.
    View in: PubMed
  32. Field CM, Wühr M, Anderson GA, Kueh HY, Strickland D, Mitchison TJ. Actin behavior in bulk cytoplasm is cell cycle regulated in early vertebrate embryos. J Cell Sci. 2011 Jun 15; 124(Pt 12):2086-95.
    View in: PubMed
  33. Hu CK, Coughlin M, Field CM, Mitchison TJ. KIF4 regulates midzone length during cytokinesis. Curr Biol. 2011 May 24; 21(10):815-24.
    View in: PubMed
  34. Shi J, Zhou Y, Huang HC, Mitchison TJ. Navitoclax (ABT-263) accelerates apoptosis during drug-induced mitotic arrest by antagonizing Bcl-xL. Cancer Res. 2011 Jul 1; 71(13):4518-26.
    View in: PubMed
  35. Brangwynne CP, Mitchison TJ, Hyman AA. Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes. Proc Natl Acad Sci U S A. 2011 Mar 15; 108(11):4334-9.
    View in: PubMed
  36. Wühr M, Obholzer ND, Megason SG, Detrich HW, Mitchison TJ. Live imaging of the cytoskeleton in early cleavage-stage zebrafish embryos. Methods Cell Biol. 2011; 101:1-18.
    View in: PubMed
  37. Huang HC, Mitchison TJ, Shi J. Stochastic competition between mechanistically independent slippage and death pathways determines cell fate during mitotic arrest. PLoS One. 2010; 5(12):e15724.
    View in: PubMed
  38. Mitchison TJ. Remaining mysteries of the cytoplasm. Mol Biol Cell. 2010 Nov 15; 21(22):3811-2.
    View in: PubMed
  39. Wühr M, Tan ES, Parker SK, Detrich HW, Mitchison TJ. A model for cleavage plane determination in early amphibian and fish embryos. Curr Biol. 2010 Nov 23; 20(22):2040-5.
    View in: PubMed
  40. Kueh HY, Brieher WM, Mitchison TJ. Quantitative analysis of actin turnover in Listeria comet tails: evidence for catastrophic filament turnover. Biophys J. 2010 Oct 6; 99(7):2153-62.
    View in: PubMed
  41. Huang HC, Shi J, Orth JD, Mitchison TJ. Cell death when the SAC is out of commission. Cell Cycle. 2010 Jun 1; 9(11):2049-50.
    View in: PubMed
  42. Martin DS, Fathi R, Mitchison TJ, Gelles J. FRET measurements of kinesin neck orientation reveal a structural basis for processivity and asymmetry. Proc Natl Acad Sci U S A. 2010 Mar 23; 107(12):5453-8.
    View in: PubMed
  43. Gatlin JC, Matov A, Danuser G, Mitchison TJ, Salmon ED. Directly probing the mechanical properties of the spindle and its matrix. J Cell Biol. 2010 Feb 22; 188(4):481-9.
    View in: PubMed
  44. Mitchison TJ, Mitchison HM. Cell biology: How cilia beat. Nature. 2010 Jan 21; 463(7279):308-9.
    View in: PubMed
  45. Needleman DJ, Groen A, Ohi R, Maresca T, Mirny L, Mitchison T. Fast microtubule dynamics in meiotic spindles measured by single molecule imaging: evidence that the spindle environment does not stabilize microtubules. Mol Biol Cell. 2010 Jan 15; 21(2):323-33.
    View in: PubMed
  46. Huang HC, Shi J, Orth JD, Mitchison TJ. Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly. Cancer Cell. 2009 Oct 6; 16(4):347-58.
    View in: PubMed
  47. Tsui M, Xie T, Orth JD, Carpenter AE, Rudnicki S, Kim S, Shamu CE, Mitchison TJ. An intermittent live cell imaging screen for siRNA enhancers and suppressors of a kinesin-5 inhibitor. PLoS One. 2009; 4(10):e7339.
    View in: PubMed
  48. Ozlü N, Monigatti F, Renard BY, Field CM, Steen H, Mitchison TJ, Steen JJ. Binding partner switching on microtubules and aurora-B in the mitosis to cytokinesis transition. Mol Cell Proteomics. 2010 Feb; 9(2):336-50.
    View in: PubMed
  49. Chang P, Coughlin M, Mitchison TJ. Interaction between Poly(ADP-ribose) and NuMA contributes to mitotic spindle pole assembly. Mol Biol Cell. 2009 Nov; 20(21):4575-85.
    View in: PubMed
  50. Dumont S, Mitchison TJ. Force and length in the mitotic spindle. Curr Biol. 2009 Sep 15; 19(17):R749-61.
    View in: PubMed
  51. Kueh HY, Mitchison TJ. Structural plasticity in actin and tubulin polymer dynamics. Science. 2009 Aug 21; 325(5943):960-3.
    View in: PubMed
  52. Charras GT, Mitchison TJ, Mahadevan L. Animal cell hydraulics. J Cell Sci. 2009 Sep 15; 122(Pt 18):3233-41.
    View in: PubMed
  53. Feng Y, Mitchison TJ, Bender A, Young DW, Tallarico JA. Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds. Nat Rev Drug Discov. 2009 Jul; 8(7):567-78.
    View in: PubMed
  54. Dumont S, Mitchison TJ. Compression regulates mitotic spindle length by a mechanochemical switch at the poles. Curr Biol. 2009 Jul 14; 19(13):1086-95.
    View in: PubMed
  55. Maresca TJ, Groen AC, Gatlin JC, Ohi R, Mitchison TJ, Salmon ED. Spindle assembly in the absence of a RanGTP gradient requires localized CPC activity. Curr Biol. 2009 Jul 28; 19(14):1210-5.
    View in: PubMed
  56. Needleman DJ, Xu Y, Mitchison TJ. Pin-hole array correlation imaging: highly parallel fluorescence correlation spectroscopy. Biophys J. 2009 Jun 17; 96(12):5050-9.
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  57. Niethammer P, Grabher C, Look AT, Mitchison TJ. A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature. 2009 Jun 18; 459(7249):996-9.
    View in: PubMed
  58. Wühr M, Mitchison TJ, Field CM. Size and speed go hand in hand in cytokinesis. Cell. 2009 May 29; 137(5):798-800.
    View in: PubMed
  59. Groen AC, Maresca TJ, Gatlin JC, Salmon ED, Mitchison TJ. Functional overlap of microtubule assembly factors in chromatin-promoted spindle assembly. Mol Biol Cell. 2009 Jun; 20(11):2766-73.
    View in: PubMed
  60. Wühr M, Dumont S, Groen AC, Needleman DJ, Mitchison TJ. How does a millimeter-sized cell find its center? Cell Cycle. 2009 Apr 15; 8(8):1115-21.
    View in: PubMed
  61. Gatlin JC, Matov A, Groen AC, Needleman DJ, Maresca TJ, Danuser G, Mitchison TJ, Salmon ED. Spindle fusion requires dynein-mediated sliding of oppositely oriented microtubules. Curr Biol. 2009 Feb 24; 19(4):287-96.
    View in: PubMed
  62. Orth JD, Tang Y, Shi J, Loy CT, Amendt C, Wilm C, Zenke FT, Mitchison TJ. Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate. Mol Cancer Ther. 2008 Nov; 7(11):3480-9.
    View in: PubMed
  63. Maloney KN, Fujita M, Eggert US, Schroeder FC, Field CM, Mitchison TJ, Clardy J. Actin-aggregating cucurbitacins from Physocarpus capitatus. J Nat Prod. 2008 Nov; 71(11):1927-9.
    View in: PubMed
  64. Kueh HY, Brieher WM, Mitchison TJ. Dynamic stabilization of actin filaments. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16531-6.
    View in: PubMed
  65. Wühr M, Mitchison TJ, Field CM. Mitosis: new roles for myosin-X and actin at the spindle. Curr Biol. 2008 Oct 14; 18(19):R912-4.
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  66. Wühr M, Chen Y, Dumont S, Groen AC, Needleman DJ, Salic A, Mitchison TJ. Evidence for an upper limit to mitotic spindle length. Curr Biol. 2008 Aug 26; 18(16):1256-61.
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  67. Kueh HY, Charras GT, Mitchison TJ, Brieher WM. Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers. J Cell Biol. 2008 Jul 28; 182(2):341-53.
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  68. Groen AC, Needleman D, Brangwynne C, Gradinaru C, Fowler B, Mazitschek R, Mitchison TJ. A novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly. J Cell Sci. 2008 Jul 15; 121(Pt 14):2293-300.
    View in: PubMed
  69. Shi J, Orth JD, Mitchison T. Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5. Cancer Res. 2008 May 1; 68(9):3269-76.
    View in: PubMed
  70. Hu CK, Coughlin M, Field CM, Mitchison TJ. Cell polarization during monopolar cytokinesis. J Cell Biol. 2008 Apr 21; 181(2):195-202.
    View in: PubMed
  71. Niethammer P, Kueh HY, Mitchison TJ. Spatial patterning of metabolism by mitochondria, oxygen, and energy sinks in a model cytoplasm. Curr Biol. 2008 Apr 22; 18(8):586-91.
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  72. Salic A, Mitchison TJ. A chemical method for fast and sensitive detection of DNA synthesis in vivo. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2415-20.
    View in: PubMed
  73. Mitchison TJ, Charras GT, Mahadevan L. Implications of a poroelastic cytoplasm for the dynamics of animal cell shape. Semin Cell Dev Biol. 2008 Jun; 19(3):215-23.
    View in: PubMed
  74. Young DW, Bender A, Hoyt J, McWhinnie E, Chirn GW, Tao CY, Tallarico JA, Labow M, Jenkins JL, Mitchison TJ, Feng Y. Integrating high-content screening and ligand-target prediction to identify mechanism of action. Nat Chem Biol. 2008 Jan; 4(1):59-68.
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  75. Galkin VE, Orlova A, Brieher W, Kueh HY, Mitchison TJ, Egelman EH. Coronin-1A stabilizes F-actin by bridging adjacent actin protomers and stapling opposite strands of the actin filament. J Mol Biol. 2008 Feb 22; 376(3):607-13.
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  76. Charras GT, Coughlin M, Mitchison TJ, Mahadevan L. Life and times of a cellular bleb. Biophys J. 2008 Mar 1; 94(5):1836-53.
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  77. Irimia D, Charras G, Agrawal N, Mitchison T, Toner M. Polar stimulation and constrained cell migration in microfluidic channels. Lab Chip. 2007 Dec; 7(12):1783-90.
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  78. Burbank KS, Mitchison TJ, Fisher DS. Slide-and-cluster models for spindle assembly. Curr Biol. 2007 Aug 21; 17(16):1373-83.
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  79. Vrabioiu AM, Mitchison TJ. Symmetry of septin hourglass and ring structures. J Mol Biol. 2007 Sep 7; 372(1):37-49.
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  80. Ohi R, Burbank K, Liu Q, Mitchison TJ. Nonredundant functions of Kinesin-13s during meiotic spindle assembly. Curr Biol. 2007 Jun 5; 17(11):953-9.
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  81. Li J, Brieher WM, Scimone ML, Kang SJ, Zhu H, Yin H, von Andrian UH, Mitchison T, Yuan J. Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization. Nat Cell Biol. 2007 Mar; 9(3):276-86.
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  82. Ribbeck K, Mitchison TJ. Meiotic spindle: sculpted by severing. Curr Biol. 2006 Nov 7; 16(21):R923-5.
    View in: PubMed
  83. Burbank KS, Groen AC, Perlman ZE, Fisher DS, Mitchison TJ. A new method reveals microtubule minus ends throughout the meiotic spindle. J Cell Biol. 2006 Nov 6; 175(3):369-75.
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  84. Charras GT, Hu CK, Coughlin M, Mitchison TJ. Reassembly of contractile actin cortex in cell blebs. J Cell Biol. 2006 Nov 6; 175(3):477-90.
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  85. Brieher WM, Kueh HY, Ballif BA, Mitchison TJ. Rapid actin monomer-insensitive depolymerization of Listeria actin comet tails by cofilin, coronin, and Aip1. J Cell Biol. 2006 Oct 23; 175(2):315-24.
    View in: PubMed
  86. Vrabioiu AM, Mitchison TJ. Structural insights into yeast septin organization from polarized fluorescence microscopy. Nature. 2006 Sep 28; 443(7110):466-9.
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  87. Burbank KS, Mitchison TJ. Microtubule dynamic instability. Curr Biol. 2006 Jul 25; 16(14):R516-7.
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  88. Eggert US, Mitchison TJ. Small molecule screening by imaging. Curr Opin Chem Biol. 2006 Jun; 10(3):232-7.
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  89. Ribbeck K, Groen AC, Santarella R, Bohnsack MT, Raemaekers T, Köcher T, Gentzel M, Görlich D, Wilm M, Carmeliet G, Mitchison TJ, Ellenberg J, Hoenger A, Mattaj IW. NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules. Mol Biol Cell. 2006 Jun; 17(6):2646-60.
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  90. Maliga Z, Mitchison TJ. Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol. BMC Chem Biol. 2006; 6:2.
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  91. De Wall SL, Painter C, Stone JD, Bandaranayake R, Wiley DC, Mitchison TJ, Stern LJ, DeDecker BS. Noble metals strip peptides from class II MHC proteins. Nat Chem Biol. 2006 Apr; 2(4):197-201.
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  92. Eggert US, Mitchison TJ, Field CM. Animal cytokinesis: from parts list to mechanisms. Annu Rev Biochem. 2006; 75:543-66.
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  93. Eggert US, Field CM, Mitchison TJ. Small molecules in an RNAi world. Mol Biosyst. 2006 Feb; 2(2):93-6.
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  94. Chang P, Coughlin M, Mitchison TJ. Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function. Nat Cell Biol. 2005 Nov; 7(11):1133-9.
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  95. Vrabioiu A, Mitchison T. Towards an understanding of yeast septins' organization in vivo. Microsc Microanal. 2005 Aug; 11 Suppl 2:262-3.
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  96. Mahadevan L, Mitchison TJ. Cell biology: powerful curves. Nature. 2005 Jun 16; 435(7044):895-7.
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  97. Dorer RK, Zhong S, Tallarico JA, Wong WH, Mitchison TJ, Murray AW. A small-molecule inhibitor of Mps1 blocks the spindle-checkpoint response to a lack of tension on mitotic chromosomes. Curr Biol. 2005 Jun 7; 15(11):1070-6.
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  98. Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol. 2005 Jul; 1(2):112-9.
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  99. Charras GT, Yarrow JC, Horton MA, Mahadevan L, Mitchison TJ. Non-equilibration of hydrostatic pressure in blebbing cells. Nature. 2005 May 19; 435(7040):365-9.
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  100. Mitchison TJ. Mechanism and function of poleward flux in Xenopus extract meiotic spindles. Philos Trans R Soc Lond B Biol Sci. 2005 Mar 29; 360(1455):623-9.
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  101. Mitchison TJ, Maddox P, Gaetz J, Groen A, Shirasu M, Desai A, Salmon ED, Kapoor TM. Roles of polymerization dynamics, opposed motors, and a tensile element in governing the length of Xenopus extract meiotic spindles. Mol Biol Cell. 2005 Jun; 16(6):3064-76.
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  102. Yarrow JC, Totsukawa G, Charras GT, Mitchison TJ. Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor. Chem Biol. 2005 Mar; 12(3):385-95.
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  103. Perlman ZE, Mitchison TJ, Mayer TU. High-content screening and profiling of drug activity in an automated centrosome-duplication assay. Chembiochem. 2005 Jan; 6(1):145-51.
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  104. Mitchison TJ. Small-molecule screening and profiling by using automated microscopy. Chembiochem. 2005 Jan; 6(1):33-9.
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  105. Miyamoto DT, Perlman ZE, Burbank KS, Groen AC, Mitchison TJ. The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles. J Cell Biol. 2004 Dec 6; 167(5):813-8.
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  106. Chang P, Jacobson MK, Mitchison TJ. Poly(ADP-ribose) is required for spindle assembly and structure. Nature. 2004 Dec 2; 432(7017):645-9.
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  107. Ramamurthy B, Yengo CM, Straight AF, Mitchison TJ, Sweeney HL. Kinetic mechanism of blebbistatin inhibition of nonmuscle myosin IIb. Biochemistry. 2004 Nov 23; 43(46):14832-9.
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  108. Perlman ZE, Slack MD, Feng Y, Mitchison TJ, Wu LF, Altschuler SJ. Multidimensional drug profiling by automated microscopy. Science. 2004 Nov 12; 306(5699):1194-8.
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  109. Shirasu-Hiza M, Perlman ZE, Wittmann T, Karsenti E, Mitchison TJ. Eg5 causes elongation of meiotic spindles when flux-associated microtubule depolymerization is blocked. Curr Biol. 2004 Nov 9; 14(21):1941-5.
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  110. Groen AC, Cameron LA, Coughlin M, Miyamoto DT, Mitchison TJ, Ohi R. XRHAMM functions in ran-dependent microtubule nucleation and pole formation during anastral spindle assembly. Curr Biol. 2004 Oct 26; 14(20):1801-11.
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  111. Valentine MT, Perlman ZE, Mitchison TJ, Weitz DA. Mechanical properties of Xenopus egg cytoplasmic extracts. Biophys J. 2005 Jan; 88(1):680-9.
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  112. Straight AF, Field CM, Mitchison TJ. Anillin binds nonmuscle myosin II and regulates the contractile ring. Mol Biol Cell. 2005 Jan; 16(1):193-201.
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  113. Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale RD, Walczak CE, Wordeman L. A standardized kinesin nomenclature. J Cell Biol. 2004 Oct 11; 167(1):19-22.
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  114. Eggert US, Kiger AA, Richter C, Perlman ZE, Perrimon N, Mitchison TJ, Field CM. Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol. 2004 Dec; 2(12):e379.
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  115. Mitchison TJ, Maddox P, Groen A, Cameron L, Perlman Z, Ohi R, Desai A, Salmon ED, Kapoor TM. Bipolarization and poleward flux correlate during Xenopus extract spindle assembly. Mol Biol Cell. 2004 Dec; 15(12):5603-15.
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  116. Yarrow JC, Perlman ZE, Westwood NJ, Mitchison TJ. A high-throughput cell migration assay using scratch wound healing, a comparison of image-based readout methods. BMC Biotechnol. 2004 Sep 9; 4:21.
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  117. Salic A, Waters JC, Mitchison TJ. Vertebrate shugoshin links sister centromere cohesion and kinetochore microtubule stability in mitosis. Cell. 2004 Sep 3; 118(5):567-78.
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  118. Margalit DN, Romberg L, Mets RB, Hebert AM, Mitchison TJ, Kirschner MW, RayChaudhuri D. Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality. Proc Natl Acad Sci U S A. 2004 Aug 10; 101(32):11821-6.
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  119. Miller SC, Mitchison TJ. Synthesis and phenotypic screening of a Guanine-mimetic library. Chembiochem. 2004 Jul 5; 5(7):1010-2.
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  120. Venkatesh N, Feng Y, DeDecker B, Yacono P, Golan D, Mitchison T, McKeon F. Chemical genetics to identify NFAT inhibitors: potential of targeting calcium mobilization in immunosuppression. Proc Natl Acad Sci U S A. 2004 Jun 15; 101(24):8969-74.
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  122. Carey KL, Westwood NJ, Mitchison TJ, Ward GE. A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7433-8.
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  123. Brieher WM, Coughlin M, Mitchison TJ. Fascin-mediated propulsion of Listeria monocytogenes independent of frequent nucleation by the Arp2/3 complex. J Cell Biol. 2004 Apr 26; 165(2):233-42.
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  124. Ohi R, Sapra T, Howard J, Mitchison TJ. Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation. Mol Biol Cell. 2004 Jun; 15(6):2895-906.
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  127. Romberg L, Mitchison TJ. Rate-limiting guanosine 5'-triphosphate hydrolysis during nucleotide turnover by FtsZ, a prokaryotic tubulin homologue involved in bacterial cell division. Biochemistry. 2004 Jan 13; 43(1):282-8.
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  128. Limouze J, Straight AF, Mitchison T, Sellers JR. Specificity of blebbistatin, an inhibitor of myosin II. J Muscle Res Cell Motil. 2004; 25(4-5):337-41.
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  129. Vrabioiu AM, Gerber SA, Gygi SP, Field CM, Mitchison TJ. The majority of the Saccharomyces cerevisiae septin complexes do not exchange guanine nucleotides. J Biol Chem. 2004 Jan 23; 279(4):3111-8.
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  131. Maddox P, Straight A, Coughlin P, Mitchison TJ, Salmon ED. Direct observation of microtubule dynamics at kinetochores in Xenopus extract spindles: implications for spindle mechanics. J Cell Biol. 2003 Aug 4; 162(3):377-82.
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  132. Ohi R, Coughlin ML, Lane WS, Mitchison TJ. An inner centromere protein that stimulates the microtubule depolymerizing activity of a KinI kinesin. Dev Cell. 2003 Aug; 5(2):309-21.
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  133. Xu J, Wang F, Van Keymeulen A, Herzmark P, Straight A, Kelly K, Takuwa Y, Sugimoto N, Mitchison T, Bourne HR. Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell. 2003 Jul 25; 114(2):201-14.
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  134. Zhai Q, Wang J, Kim A, Liu Q, Watts R, Hoopfer E, Mitchison T, Luo L, He Z. Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration. Neuron. 2003 Jul 17; 39(2):217-25.
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  135. Yarrow JC, Lechler T, Li R, Mitchison TJ. Rapid de-localization of actin leading edge components with BDM treatment. BMC Cell Biol. 2003 Jun 3; 4:5.
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  137. Feng Y, Yu S, Lasell TK, Jadhav AP, Macia E, Chardin P, Melancon P, Roth M, Mitchison T, Kirchhausen T. Exo1: a new chemical inhibitor of the exocytic pathway. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6469-74.
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  138. Shirasu-Hiza M, Coughlin P, Mitchison T. Identification of XMAP215 as a microtubule-destabilizing factor in Xenopus egg extract by biochemical purification. J Cell Biol. 2003 Apr 28; 161(2):349-58.
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  150. Maliga Z, Kapoor TM, Mitchison TJ. Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5. Chem Biol. 2002 Sep; 9(9):989-96.
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  161. Haggarty SJ, Mayer TU, Miyamoto DT, Fathi R, King RW, Mitchison TJ, Schreiber SL. Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis. Chem Biol. 2000 Apr; 7(4):275-86.
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  162. Taunton J, Rowning BA, Coughlin ML, Wu M, Moon RT, Mitchison TJ, Larabell CA. Actin-dependent propulsion of endosomes and lysosomes by recruitment of N-WASP. J Cell Biol. 2000 Feb 7; 148(3):519-30.
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  169. Weiner OD, Servant G, Welch MD, Mitchison TJ, Sedat JW, Bourne HR. Spatial control of actin polymerization during neutrophil chemotaxis. Nat Cell Biol. 1999 Jun; 1(2):75-81.
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  175. Yoshihara HA, Chiellini G, Mitchison TJ, Scanlan TS. An efficient substitution reaction for the preparation of thyroid hormone analogues. Bioorg Med Chem. 1998 Aug; 6(8):1179-83.
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  176. Welch MD, Rosenblatt J, Skoble J, Portnoy DA, Mitchison TJ. Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation. Science. 1998 Jul 3; 281(5373):105-8.
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  191. Cramer LP, Siebert M, Mitchison TJ. Identification of novel graded polarity actin filament bundles in locomoting heart fibroblasts: implications for the generation of motile force. J Cell Biol. 1997 Mar 24; 136(6):1287-305.
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  251. Chain BM, Mitchison NA, Mitchison TJ, Davies DH, Marcinkiewicz J. Antigen processing: current issues, exceptional cases (Thy 1 alloantigen, MHC class-II-restricted cytolytic T cells), and implications for vaccine development. J Autoimmun. 1989 Jun; 2 Suppl:45-53.
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  252. Mitchison TJ. Mitosis: basic concepts. Curr Opin Cell Biol. 1989 Feb; 1(1):67-74.
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  253. Mitchison T, Hyman A. Cell division. Kinetochores on the move. Nature. 1988 Nov 17; 336(6196):200-1.
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  254. Mitchison T, Kirschner M. Cytoskeletal dynamics and nerve growth. Neuron. 1988 Nov; 1(9):761-72.
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  255. Kellogg DR, Mitchison TJ, Alberts BM. Behaviour of microtubules and actin filaments in living Drosophila embryos. Development. 1988 Aug; 103(4):675-86.
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  256. Koshland DE, Mitchison TJ, Kirschner MW. Polewards chromosome movement driven by microtubule depolymerization in vitro. Nature. 1988 Feb 11; 331(6156):499-504.
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  257. Mitchison TJ. Microtubule dynamics and kinetochore function in mitosis. Annu Rev Cell Biol. 1988; 4:527-49.
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  258. Mitchison TJ, Kirschner MW. Some thoughts on the partitioning of tubulin between monomer and polymer under conditions of dynamic instability. Cell Biophys. 1987 Dec; 11:35-55.
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  259. Mitchison TJ. Cell motility: good things from slime. Nature. 1987 Aug 20-26; 328(6132):665.
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  260. Kirschner MW, Mitchison T. Microtubule dynamics. Nature. 1986 Dec 18-31; 324(6098):621.
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  261. Mitchison T, Evans L, Schulze E, Kirschner M. Sites of microtubule assembly and disassembly in the mitotic spindle. Cell. 1986 May 23; 45(4):515-27.
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  262. Kirschner M, Mitchison T. Beyond self-assembly: from microtubules to morphogenesis. Cell. 1986 May 9; 45(3):329-42.
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  263. Kristofferson D, Mitchison T, Kirschner M. Direct observation of steady-state microtubule dynamics. J Cell Biol. 1986 Mar; 102(3):1007-19.
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  264. Mitchison TJ, Kirschner MW. Isolation of mammalian centrosomes. Methods Enzymol. 1986; 134:261-8.
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  265. Mitchison TJ. The role of microtubule polarity in the movement of kinesin and kinetochores. J Cell Sci Suppl. 1986; 5:121-8.
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  266. Vale RD, Schnapp BJ, Mitchison T, Steuer E, Reese TS, Sheetz MP. Different axoplasmic proteins generate movement in opposite directions along microtubules in vitro. Cell. 1985 Dec; 43(3 Pt 2):623-32.
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  267. Mitchison TJ, Kirschner MW. Properties of the kinetochore in vitro. II. Microtubule capture and ATP-dependent translocation. J Cell Biol. 1985 Sep; 101(3):766-77.
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  268. Mitchison TJ, Kirschner MW. Properties of the kinetochore in vitro. I. Microtubule nucleation and tubulin binding. J Cell Biol. 1985 Sep; 101(3):755-65.
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  269. Evans L, Mitchison T, Kirschner M. Influence of the centrosome on the structure of nucleated microtubules. J Cell Biol. 1985 Apr; 100(4):1185-91.
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  270. Leslie RJ, Saxton WM, Mitchison TJ, Neighbors B, Salmon ED, McIntosh JR. Assembly properties of fluorescein-labeled tubulin in vitro before and after fluorescence bleaching. J Cell Biol. 1984 Dec; 99(6):2146-56.
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  271. Mitchison T, Kirschner M. Microtubule assembly nucleated by isolated centrosomes. Nature. 1984 Nov 15-21; 312(5991):232-7.
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  272. Mitchison T, Kirschner M. Dynamic instability of microtubule growth. Nature. 1984 Nov 15-21; 312(5991):237-42.
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  273. Karsenti E, Kobayashi S, Mitchison T, Kirschner M. Role of the centrosome in organizing the interphase microtubule array: properties of cytoplasts containing or lacking centrosomes. J Cell Biol. 1984 May; 98(5):1763-76.
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  274. Calarco-Gillam PD, Siebert MC, Hubble R, Mitchison T, Kirschner M. Centrosome development in early mouse embryos as defined by an autoantibody against pericentriolar material. Cell. 1983 Dec; 35(3 Pt 2):621-9.
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  275. Mitchison TJ, Sedat J. Localization of antigenic determinants in whole Drosophila embryos. Dev Biol. 1983 Sep; 99(1):261-4.
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  276. Sambrook J, Botchan M, Hu SL, Mitchison T, Stringer J. Integration of viral DNA sequences in cells transformed by adenovirus 2 or SV40. Proc R Soc Lond B Biol Sci. 1980 Nov 19; 210(1180):423-35.
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  277. Botchan M, Stringer J, Mitchison T, Sambrook J. Integration and excision of SV40 DNA from the chromosome of a transformed cell. Cell. 1980 May; 20(1):143-52.
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  278. Sambrook J, Greene R, Stringer J, Mitchison T, Hu SL, Botchan M. Analysis of the sites of integration of viral DNA sequences in rat cells transformed by adenovirus 2 or SV40. Cold Spring Harb Symp Quant Biol. 1980; 44 Pt 1,:569-84.
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