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James B. Whitney, Ph.D.

TitleInstructor in Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Medical Center
Viral Pathogenesis Div - RE 113
330 Brookline Ave
Boston MA 02215
Phone617/667-2042
Fax617/667-8210

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Barouch DH, Whitney JB, Moldt B, Klein F, Oliveira TY, Liu J, Stephenson KE, Chang HW, Shekhar K, Gupta S, Nkolola JP, Seaman MS, Smith KM, Borducchi EN, Cabral C, Smith JY, Blackmore S, Sanisetty S, Perry JR, Beck M, Lewis MG, Rinaldi W, Chakraborty AK, Poignard P, Nussenzweig MC, Burton DR. Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Nature. 2013 Nov 14; 503(7475):224-8.
    View in: PubMed
  2. Asmal M, Whitney JB, Luedemann C, Carville A, Steen R, Letvin NL, Geiben-Lynn R. In Vivo Anti-HIV Activity of the Heparin-Activated Serine Protease Inhibitor Antithrombin III Encapsulated in Lymph-Targeting Immunoliposomes. PLoS One. 2012; 7(11):e48234.
    View in: PubMed
  3. Whitney JB, Lim SY, Wainberg MA. Evolutionary mechanisms of retroviral persistence. AIDS Rev. 2011 Oct-Dec; 13(4):234-9.
    View in: PubMed
  4. Yeh WW, Rao SS, Lim SY, Zhang J, Hraber PT, Brassard LM, Luedemann C, Todd JP, Dodson A, Shen L, Buzby AP, Whitney JB, Korber BT, Nabel GJ, Mascola JR, Letvin NL. The TRIM5 gene modulates penile mucosal acquisition of simian immunodeficiency virus in rhesus monkeys. J Virol. 2011 Oct; 85(19):10389-98.
    View in: PubMed
  5. Letvin NL, Rao SS, Montefiori DC, Seaman MS, Sun Y, Lim SY, Yeh WW, Asmal M, Gelman RS, Shen L, Whitney JB, Seoighe C, Lacerda M, Keating S, Norris PJ, Hudgens MG, Gilbert PB, Buzby AP, Mach LV, Zhang J, Balachandran H, Shaw GM, Schmidt SD, Todd JP, Dodson A, Mascola JR, Nabel GJ. Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys. Sci Transl Med. 2011 May 4; 3(81):81ra36.
    View in: PubMed
  6. Whitney JB, Asmal M, Geiben-Lynn R. Serpin induced antiviral activity of prostaglandin synthetase-2 against HIV-1 replication. PLoS One. 2011; 6(4):e18589.
    View in: PubMed
  7. Whitney JB, Hraber PT, Luedemann C, Giorgi EE, Daniels MG, Bhattacharya T, Rao SS, Mascola JR, Nabel GJ, Korber BT, Letvin NL. Genital tract sequestration of SIV following acute infection. PLoS Pathog. 2011 Feb; 7(2):e1001293.
    View in: PubMed
  8. Whitney JB, Mirshahidi S, Lim SY, Goins L, Ibegbu CC, Anderson DC, Raybourne RB, Frankel FR, Lieberman J, Ruprecht RM. Prior exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against HIV. J Immune Based Ther Vaccines. 2011; 9:2.
    View in: PubMed
  9. Masek-Hammerman K, Li H, Liu J, Abbink P, La Porte A, O'Brien KL, Whitney JB, Carville A, Mansfield KG, Barouch DH. Mucosal trafficking of vector-specific CD4+ T lymphocytes following vaccination of rhesus monkeys with adenovirus serotype 5. J Virol. 2010 Oct; 84(19):9810-6.
    View in: PubMed
  10. Lim SY, Chan T, Gelman RS, Whitney JB, O'Brien KL, Barouch DH, Goldstein DB, Haynes BF, Letvin NL. Contributions of Mamu-A*01 status and TRIM5 allele expression, but not CCL3L copy number variation, to the control of SIVmac251 replication in Indian-origin rhesus monkeys. PLoS Genet. 2010 Jun; 6(6):e1000997.
    View in: PubMed
  11. Yeh WW, Rahman I, Hraber P, Coffey RT, Nevidomskyte D, Giri A, Asmal M, Miljkovic S, Daniels M, Whitney JB, Keele BF, Hahn BH, Korber BT, Shaw GM, Seaman MS, Letvin NL. Autologous neutralizing antibodies to the transmitted/founder viruses emerge late after simian immunodeficiency virus SIVmac251 infection of rhesus monkeys. J Virol. 2010 Jun; 84(12):6018-32.
    View in: PubMed
  12. Lim SY, Rogers T, Chan T, Whitney JB, Kim J, Sodroski J, Letvin NL. TRIM5alpha Modulates Immunodeficiency Virus Control in Rhesus Monkeys. PLoS Pathog. 2010 Jan; 6(1):e1000738.
    View in: PubMed
  13. Basavapathruni A, Yeh WW, Coffey RT, Whitney JB, Hraber PT, Giri A, Korber BT, Rao SS, Nabel GJ, Mascola JR, Seaman MS, Letvin NL. Envelope vaccination shapes viral envelope evolution following simian immunodeficiency virus infection in rhesus monkeys. J Virol. 2010 Jan; 84(2):953-63.
    View in: PubMed
  14. Whitney JB, Luedemann C, Bao S, Miura A, Rao SS, Mascola JR, Letvin NL. Monitoring HIV vaccine trial participants for primary infection: studies in the SIV/macaque model. AIDS. 2009 Jul 31; 23(12):1453-60.
    View in: PubMed
  15. Whitney JB, Luedemann C, Hraber P, Rao SS, Mascola JR, Nabel GJ, Letvin NL. T-cell vaccination reduces simian immunodeficiency virus levels in semen. J Virol. 2009 Oct; 83(20):10840-3.
    View in: PubMed
  16. Mirshahidi S, Kramer VG, Whitney JB, Essono S, Lee S, Dranoff G, Anderson KS, Ruprecht RM. Overlapping synthetic peptides encoding TPD52 as breast cancer vaccine in mice: prolonged survival. Vaccine. 2009 Mar 13; 27(12):1825-33.
    View in: PubMed
  17. Permar SR, Kang HH, Carville A, Mansfield KG, Gelman RS, Rao SS, Whitney JB, Letvin NL. Potent simian immunodeficiency virus-specific cellular immune responses in the breast milk of simian immunodeficiency virus-infected, lactating rhesus monkeys. J Immunol. 2008 Sep 1; 181(5):3643-50.
    View in: PubMed
  18. Whitney JB, Wainberg MA. Recovery of fitness of a live attenuated simian immunodeficiency virus through compensation in both the coding and non-coding regions of the viral genome. Retrovirology. 2007; 4:44.
    View in: PubMed
  19. Whitney JB, Wainberg MA. Impaired RNA incorporation and dimerization in live attenuated leader-variants of SIVmac239. Retrovirology. 2006; 3:96.
    View in: PubMed
  20. Wu Y, Hong K, Chenine AL, Whitney JB, Xu W, Chen Q, Geng Y, Ruprecht RM, Shao Y. Molecular cloning and in vitro evaluation of an infectious simian-human immunodeficiency virus containing env of a primary Chinese HIV-1 subtype C isolate. J Med Primatol. 2005 Apr; 34(2):101-7.
    View in: PubMed
  21. Whitney JB, Ruprecht RM. Live attenuated HIV vaccines: pitfalls and prospects. Curr Opin Infect Dis. 2004 Feb; 17(1):17-26.
    View in: PubMed
  22. Guo X, Hu J, Whitney JB, Russell RS, Liang C. Important role for the CA-NC spacer region in the assembly of bovine immunodeficiency virus Gag protein. J Virol. 2004 Jan; 78(2):551-60.
    View in: PubMed
  23. Liang C, Hu J, Whitney JB, Kleiman L, Wainberg MA. A structurally disordered region at the C terminus of capsid plays essential roles in multimerization and membrane binding of the gag protein of human immunodeficiency virus type 1. J Virol. 2003 Feb; 77(3):1772-83.
    View in: PubMed
  24. Whitney JB, Oliveira M, Detorio M, Guan Y, Wainberg MA. The M184V mutation in reverse transcriptase can delay reversion of attenuated variants of simian immunodeficiency virus. J Virol. 2002 Sep; 76(17):8958-62.
    View in: PubMed
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