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Noriaki Ikemoto, PH.D.

TitlePrincipal Associate in Neuropathology
InstitutionMassachusetts General Hospital
DepartmentNeurology
AddressBbri
64 Grove Street
Watertown MA 02472
Phone617/658-7774
Fax617/972-1761

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hino A, Yano M, Kato T, Fukuda M, Suetomi T, Ono M, Murakami W, Susa T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M. Enhanced binding of calmodulin to the ryanodine receptor corrects contractile dysfunction in failing hearts. Cardiovasc Res. 2012 Dec 1; 96(3):433-43.
    View in: PubMed
  2. Gangopadhyay JP, Ikemoto N. Aberrant interaction of calmodulin with the ryanodine receptor develops hypertrophy in the neonatal cardiomyocyte. Biochem J. 2011 Sep 1; 438(2):379-87.
    View in: PubMed
  3. Suetomi T, Yano M, Uchinoumi H, Fukuda M, Hino A, Ono M, Xu X, Tateishi H, Okuda S, Doi M, Kobayashi S, Ikeda Y, Yamamoto T, Ikemoto N, Matsuzaki M. Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca²?release leading to catecholaminergic polymorphic ventricular tachycardia. Circulation. 2011 Aug 9; 124(6):682-94.
    View in: PubMed
  4. Olojo RO, Hernández-Ochoa EO, Ikemoto N, Schneider MF. Effects of conformational peptide probe DP4 on bidirectional signaling between DHPR and RyR1 calcium channels in voltage-clamped skeletal muscle fibers. Biophys J. 2011 May 18; 100(10):2367-77.
    View in: PubMed
  5. Gangopadhyay JP, Ikemoto N. Intracellular translocation of calmodulin and Ca2+/calmodulin-dependent protein kinase II during the development of hypertrophy in neonatal cardiomyocytes. Biochem Biophys Res Commun. 2010 May 28; 396(2):515-21.
    View in: PubMed
  6. Liu Z, Wang R, Tian X, Zhong X, Gangopadhyay J, Cole R, Ikemoto N, Chen SR, Wagenknecht T. Dynamic, inter-subunit interactions between the N-terminal and central mutation regions of cardiac ryanodine receptor. J Cell Sci. 2010 May 15; 123(Pt 10):1775-84.
    View in: PubMed
  7. Ono M, Yano M, Hino A, Suetomi T, Xu X, Susa T, Uchinoumi H, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M. Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca(2+) release in heart failure. Cardiovasc Res. 2010 Sep 1; 87(4):609-17.
    View in: PubMed
  8. Uchinoumi H, Yano M, Suetomi T, Ono M, Xu X, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M. Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor. Circ Res. 2010 Apr 30; 106(8):1413-24.
    View in: PubMed
  9. Xu X, Yano M, Uchinoumi H, Hino A, Suetomi T, Ono M, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ikemoto N, Matsuzaki M. Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction. Biochem Biophys Res Commun. 2010 Apr 9; 394(3):660-6.
    View in: PubMed
  10. Kobayashi S, Yano M, Suetomi T, Ono M, Tateishi H, Mochizuki M, Xu X, Uchinoumi H, Okuda S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M. Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor. J Am Coll Cardiol. 2009 May 26; 53(21):1993-2005.
    View in: PubMed
  11. Hamada T, Gangopadhyay JP, Mandl A, Erhardt P, Ikemoto N. Defective regulation of the ryanodine receptor induces hypertrophy in cardiomyocytes. Biochem Biophys Res Commun. 2009 Mar 13; 380(3):493-7.
    View in: PubMed
  12. Kimura T, Lueck JD, Harvey PJ, Pace SM, Ikemoto N, Casarotto MG, Dirksen RT, Dulhunty AF. Alternative splicing of RyR1 alters the efficacy of skeletal EC coupling. Cell Calcium. 2009 Mar; 45(3):264-74.
    View in: PubMed
  13. Shtifman A, Ward CW, Laver DR, Bannister ML, Lopez JR, Kitazawa M, LaFerla FM, Ikemoto N, Querfurth HW. Amyloid-ß protein impairs Ca2+ release and contractility in skeletal muscle. Neurobiol Aging. 2010 Dec; 31(12):2080-90.
    View in: PubMed
  14. Tateishi H, Yano M, Mochizuki M, Suetomi T, Ono M, Xu X, Uchinoumi H, Okuda S, Oda T, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M. Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts. Cardiovasc Res. 2009 Feb 15; 81(3):536-45.
    View in: PubMed
  15. Gangopadhyay JP, Ikemoto N. Interaction of the Lys(3614)-Asn(3643) calmodulin-binding domain with the Cys(4114)-Asn(4142) region of the type 1 ryanodine receptor is involved in the mechanism of Ca2+/agonist-induced channel activation. Biochem J. 2008 Apr 15; 411(2):415-23.
    View in: PubMed
  16. Yamamoto T, Yano M, Xu X, Uchinoumi H, Tateishi H, Mochizuki M, Oda T, Kobayashi S, Ikemoto N, Matsuzaki M. Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts. Circulation. 2008 Feb 12; 117(6):762-72.
    View in: PubMed
  17. Laver DR, Honen BN, Lamb GD, Ikemoto N. A domain peptide of the cardiac ryanodine receptor regulates channel sensitivity to luminal Ca2+ via cytoplasmic Ca2+ sites. Eur Biophys J. 2008 Apr; 37(4):455-67.
    View in: PubMed
  18. Laver DR, Hamada T, Fessenden JD, Ikemoto N. The ryanodine receptor pore blocker neomycin also inhibits channel activity via a previously undescribed high-affinity Ca(2+) binding site. J Membr Biol. 2007 Dec; 220(1-3):11-20.
    View in: PubMed
  19. Mochizuki M, Yano M, Oda T, Tateishi H, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M. Scavenging free radicals by low-dose carvedilol prevents redox-dependent Ca2+ leak via stabilization of ryanodine receptor in heart failure. J Am Coll Cardiol. 2007 Apr 24; 49(16):1722-32.
    View in: PubMed
  20. Hamada T, Bannister ML, Ikemoto N. Peptide probe study of the role of interaction between the cytoplasmic and transmembrane domains of the ryanodine receptor in the channel regulation mechanism. Biochemistry. 2007 Apr 10; 46(14):4272-9.
    View in: PubMed
  21. Murayama T, Oba T, Hara H, Wakebe K, Ikemoto N, Ogawa Y. Postulated role of interdomain interaction between regions 1 and 2 within type 1 ryanodine receptor in the pathogenesis of porcine malignant hyperthermia. Biochem J. 2007 Mar 1; 402(2):349-57.
    View in: PubMed
  22. Bannister ML, Hamada T, Murayama T, Harvey PJ, Casarotto MG, Dulhunty AF, Ikemoto N. Malignant hyperthermia mutation sites in the Leu2442-Pro2477 (DP4) region of RyR1 (ryanodine receptor 1) are clustered in a structurally and functionally definable area. Biochem J. 2007 Jan 1; 401(1):333-9.
    View in: PubMed
  23. Yang Z, Ikemoto N, Lamb GD, Steele DS. The RyR2 central domain peptide DPc10 lowers the threshold for spontaneous Ca2+ release in permeabilized cardiomyocytes. Cardiovasc Res. 2006 Jun 1; 70(3):475-85.
    View in: PubMed
  24. Bannister ML, Ikemoto N. Effects of peptide C corresponding to the Glu724-Pro760 region of the II-III loop of the DHP (dihydropyridine) receptor alpha1 subunit on the domain- switch-mediated activation of RyR1 (ryanodine receptor 1) Ca2+ channels. Biochem J. 2006 Feb 15; 394(Pt 1):145-52.
    View in: PubMed
  25. Gangopadhyay JP, Ikemoto N. Role of the Met3534-Ala4271 region of the ryanodine receptor in the regulation of Ca2+ release induced by calmodulin binding domain peptide. Biophys J. 2006 Mar 15; 90(6):2015-26.
    View in: PubMed
  26. Yano M, Okuda S, Oda T, Tokuhisa T, Tateishi H, Mochizuki M, Noma T, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M. Correction of defective interdomain interaction within ryanodine receptor by antioxidant is a new therapeutic strategy against heart failure. Circulation. 2005 Dec 6; 112(23):3633-43.
    View in: PubMed
  27. Yano M, Yamamoto T, Ikemoto N, Matsuzaki M. Abnormal ryanodine receptor function in heart failure. Pharmacol Ther. 2005 Sep; 107(3):377-91.
    View in: PubMed
  28. Oda T, Yano M, Yamamoto T, Tokuhisa T, Okuda S, Doi M, Ohkusa T, Ikeda Y, Kobayashi S, Ikemoto N, Matsuzaki M. Defective regulation of interdomain interactions within the ryanodine receptor plays a key role in the pathogenesis of heart failure. Circulation. 2005 Jun 28; 111(25):3400-10.
    View in: PubMed
  29. Paul-Pletzer K, Yamamoto T, Ikemoto N, Jimenez LS, Morimoto H, Williams PG, Ma J, Parness J. Probing a putative dantrolene-binding site on the cardiac ryanodine receptor. Biochem J. 2005 May 1; 387(Pt 3):905-9.
    View in: PubMed
  30. Murayama T, Oba T, Kobayashi S, Ikemoto N, Ogawa Y. Postulated role of interdomain interactions within the type 1 ryanodine receptor in the low gain of Ca2+-induced Ca2+ release activity of mammalian skeletal muscle sarcoplasmic reticulum. Am J Physiol Cell Physiol. 2005 Jun; 288(6):C1222-30.
    View in: PubMed
  31. Kobayashi S, Bannister ML, Gangopadhyay JP, Hamada T, Parness J, Ikemoto N. Dantrolene stabilizes domain interactions within the ryanodine receptor. J Biol Chem. 2005 Feb 25; 280(8):6580-7.
    View in: PubMed
  32. Gangopadhyay JP, Grabarek Z, Ikemoto N. Fluorescence probe study of Ca2+-dependent interactions of calmodulin with calmodulin-binding peptides of the ryanodine receptor. Biochem Biophys Res Commun. 2004 Oct 22; 323(3):760-8.
    View in: PubMed
  33. Kobayashi S, Yamamoto T, Parness J, Ikemoto N. Antibody probe study of Ca2+ channel regulation by interdomain interaction within the ryanodine receptor. Biochem J. 2004 Jun 1; 380(Pt 2):561-9.
    View in: PubMed
  34. Paul-Pletzer K, Yamamoto T, Bhat MB, Ma J, Ikemoto N, Jimenez LS, Morimoto H, Williams PG, Parness J. Identification of a dantrolene-binding sequence on the skeletal muscle ryanodine receptor. J Biol Chem. 2002 Sep 20; 277(38):34918-23.
    View in: PubMed
  35. Yamamoto T, Ikemoto N. Peptide probe study of the critical regulatory domain of the cardiac ryanodine receptor. Biochem Biophys Res Commun. 2002 Mar 8; 291(4):1102-8.
    View in: PubMed
  36. Ikemoto N, Yamamoto T. Regulation of calcium release by interdomain interaction within ryanodine receptors. Front Biosci. 2002 Mar 1; 7:d671-83.
    View in: PubMed
  37. Yamamoto T, Ikemoto N. Spectroscopic monitoring of local conformational changes during the intramolecular domain-domain interaction of the ryanodine receptor. Biochemistry. 2002 Feb 5; 41(5):1492-501.
    View in: PubMed
  38. Shtifman A, Ward CW, Yamamoto T, Wang J, Olbinski B, Valdivia HH, Ikemoto N, Schneider MF. Interdomain interactions within ryanodine receptors regulate Ca2+ spark frequency in skeletal muscle. J Gen Physiol. 2002 Jan; 119(1):15-32.
    View in: PubMed
  39. Yamamoto T, Ikemoto N. T-tubule depolarization-induced local events in the ryanodine receptor, as monitored with the fluorescent conformational probe incorporated by mediation of peptide A. J Biol Chem. 2002 Jan 11; 277(2):984-92.
    View in: PubMed
  40. Yamamoto T, Rodriguez J, Ikemoto N. Ca2+-dependent dual functions of peptide C. The peptide corresponding to the Glu724-Pro760 region (the so-called determinant of excitation-contraction coupling) of the dihydropyridine receptor alpha 1 subunit II-III loop. J Biol Chem. 2002 Jan 11; 277(2):993-1001.
    View in: PubMed
  41. Ikemoto N, Yamamoto T. The luminal Ca2+ transient controls Ca2+ release/re-uptake of sarcoplasmic reticulum. Biochem Biophys Res Commun. 2000 Dec 29; 279(3):858-63.
    View in: PubMed
  42. Ikemoto N, Yamamoto T. Postulated role of inter-domain interaction within the ryanodine receptor in Ca(2+) channel regulation. Trends Cardiovasc Med. 2000 Oct; 10(7):310-6.
    View in: PubMed
  43. Yamamoto T, El-Hayek R, Ikemoto N. Postulated role of interdomain interaction within the ryanodine receptor in Ca(2+) channel regulation. J Biol Chem. 2000 Apr 21; 275(16):11618-25.
    View in: PubMed
  44. El-Hayek R, Saiki Y, Yamamoto T, Ikemoto N. A postulated role of the near amino-terminal domain of the ryanodine receptor in the regulation of the sarcoplasmic reticulum Ca(2+) channel. J Biol Chem. 1999 Nov 19; 274(47):33341-7.
    View in: PubMed
  45. Saiki Y, El-Hayek R, Ikemoto N. Involvement of the Glu724-Pro760 region of the dihydropyridine receptor II-III loop in skeletal muscle-type excitation-contraction coupling. J Biol Chem. 1999 Mar 19; 274(12):7825-32.
    View in: PubMed
  46. Saiki Y, Ikemoto N. Coordination between Ca2+ release and subsequent re-uptake in the sarcoplasmic reticulum. Biochemistry. 1999 Mar 9; 38(10):3112-9.
    View in: PubMed
  47. Saiki Y, Ikemoto N. Fluorescence probe study of the lumenal Ca2+ of the sarcoplasmic reticulum vesicles during Ca2+ uptake and Ca2+ release. Biochem Biophys Res Commun. 1997 Dec 8; 241(1):181-6.
    View in: PubMed
  48. Kim DH, Sreter FA, Ohnishi ST, Ryan JF, Roberts J, Allen PD, Meszaros LG, Antoniu B, Ikemoto N. Kinetic studies of Ca2+ release from sarcoplasmic reticulum of normal and malignant hyperthermia susceptible pig muscles. Biochim Biophys Acta. 1984 Sep 5; 775(3):320-7.
    View in: PubMed
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