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Thomas Seth Kupper, M.D.

TitleThomas B. Fitzpatrick Professor of Dermatology
InstitutionBrigham and Women's Hospital
DepartmentDermatology
AddressHarvard Institutes of Medicine
BWH Dermatology, Rm 671
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/525-5550
Fax617/525-5571
Other Positions
TitleHead of the Department of Dermatology at Brigham and Women's Hospital
InstitutionBrigham and Women's Hospital
DepartmentDermatology


 Mentoring 
 completed student projects
Epidermal Antigens in Psoriasis
Full Time/Year Long, 09/04/01 - 08/01/02
T Cells and Defensins: An Interface Between Innate and Acquired Immunity PASTEUR
Summer, 06/26/00 - 08/18/00
The Regulation and Expression of T-Lymphocyte Skin-Homing Receptors, CLA and CCR4-Implications for CTCL
Full Time/Year Long, 11/15/99 - 12/15/00

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hijnen D, Knol EF, Gent YY, Giovannone B, J P Beijn S, Kupper TS, Bruijnzeel-Koomen CA, Clark RA. CD8(+) T Cells in the Lesional Skin of Atopic Dermatitis and Psoriasis Patients Are an Important Source of IFN-?, IL-13, IL-17, and IL-22. J Invest Dermatol. 2013 Apr; 133(4):973-9.
    View in: PubMed
  2. Litvinov IV, Kupper TS, Sasseville D. The role of AHI1 and CDKN1C in cutaneous T-cell lymphoma progression. Exp Dermatol. 2012 Dec; 21(12):964-6.
    View in: PubMed
  3. Shoag J, Haq R, Zhang M, Liu L, Rowe GC, Jiang A, Koulisis N, Farrel C, Amos CI, Wei Q, Lee JE, Zhang J, Kupper TS, Qureshi AA, Cui R, Han J, Fisher DE, Arany Z. PGC-1 Coactivators Regulate MITF and the Tanning Response. Mol Cell. 2013 Jan 10; 49(1):145-57.
    View in: PubMed
  4. Rodig SJ, Cheng J, Wardzala J, Dorosario A, Scanlon JJ, Laga AC, Martinez-Fernandez A, Barletta JA, Bellizzi AM, Sadasivam S, Holloway DT, Cooper DJ, Kupper TS, Wang LC, Decaprio JA. Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus. J Clin Invest. 2012 Dec 3; 122(12):4645-53.
    View in: PubMed
  5. Alloo A, Desimone JA, Kupper TS. Mycosis fungoides presenting at the site of a transdermal estradiol patch. J Am Acad Dermatol. 2012 Nov; 67(5):e207-8.
    View in: PubMed
  6. Han T, Abdel-Motal UM, Chang DK, Sui J, Muvaffak A, Campbell J, Zhu Q, Kupper TS, Marasco WA. Human anti-CCR4 minibody gene transfer for the treatment of cutaneous T-cell lymphoma. PLoS One. 2012; 7(9):e44455.
    View in: PubMed
  7. Litvinov IV, Zhou Y, Kupper TS, Sasseville D. Loss of BCL7A expression correlates with poor disease prognosis in patients with early-stage cutaneous T-cell lymphoma. Leuk Lymphoma. 2013 Mar; 54(3):653-4.
    View in: PubMed
  8. Chang DK, Sui J, Geng S, Muvaffak A, Bai M, Fuhlbrigge RC, Lo A, Yammanuru A, Hubbard L, Sheehan J, Campbell JJ, Zhu Q, Kupper TS, Marasco WA. Humanization of an Anti-CCR4 Antibody That Kills Cutaneous T-Cell Lymphoma Cells and Abrogates Suppression by T-Regulatory Cells. Mol Cancer Ther. 2012 Nov; 11(11):2451-61.
    View in: PubMed
  9. Velez NF, Ishizawar RC, Dellaripa PF, Saavedra AP, Laga AC, Murphy GF, Fisher DC, Kupper TS, Vleugels RA. Full facial edema: a novel presentation of subcutaneous panniculitis-like T-cell lymphoma. J Clin Oncol. 2012 Sep 1; 30(25):e233-6.
    View in: PubMed
  10. Seneschal J, Clark RA, Gehad A, Baecher-Allan CM, Kupper TS. Human epidermal langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells. Immunity. 2012 May 25; 36(5):873-84.
    View in: PubMed
  11. Cedeno-Laurent F, Watanabe R, Teague JE, Kupper TS, Clark RA, Dimitroff CJ. Galectin-1 inhibits the viability, proliferation, and Th1 cytokine production of nonmalignant T cells in patients with leukemic cutaneous T-cell lymphoma. Blood. 2012 Apr 12; 119(15):3534-8.
    View in: PubMed
  12. Müller J, Friedrich M, Becher T, Braunstein J, Kupper T, Berdel P, Gravius S, Rohrbach F, Oldenburg J, Mayer G, Pötzsch B. Monitoring of plasma levels of activated protein C using a clinically applicable oligonucleotide-based enzyme capture assay. J Thromb Haemost. 2012 Mar; 10(3):390-8.
    View in: PubMed
  13. Jiang X, Clark RA, Liu L, Wagers AJ, Fuhlbrigge RC, Kupper TS. Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity. Nature. 2012 Mar 8; 483(7388):227-31.
    View in: PubMed
  14. Tian T, Dubin K, Jin Q, Qureshi A, King SL, Liu L, Jiang X, Murphy GF, Kupper TS, Fuhlbrigge RC. Disruption of TNF-a/TNFR1 function in resident skin cells impairs host immune response against cutaneous vaccinia virus infection. J Invest Dermatol. 2012 May; 132(5):1425-34.
    View in: PubMed
  15. Clark RA, Watanabe R, Teague JE, Schlapbach C, Tawa MC, Adams N, Dorosario AA, Chaney KS, Cutler CS, Leboeuf NR, Carter JB, Fisher DC, Kupper TS. Skin effector memory T cells do not recirculate and provide immune protection in alemtuzumab-treated CTCL patients. Sci Transl Med. 2012 Jan 18; 4(117):117ra7.
    View in: PubMed
  16. Kupper TS. Old and new: recent innovations in vaccine biology and skin T cells. J Invest Dermatol. 2012 Mar; 132(3 Pt 2):829-34.
    View in: PubMed
  17. Curiel-Lewandrowski C, Yamasaki H, Si CP, Jin X, Zhang Y, Richmond J, Tuzova M, Wilson K, Sullivan B, Jones D, Ryzhenko N, Little F, Kupper TS, Center DM, Cruikshank WW. Loss of nuclear pro-IL-16 facilitates cell cycle progression in human cutaneous T cell lymphoma. J Clin Invest. 2011 Dec; 121(12):4838-49.
    View in: PubMed
  18. Purwar R, Campbell J, Murphy G, Richards WG, Clark RA, Kupper TS. Resident memory T cells (T(RM)) are abundant in human lung: diversity, function, and antigen specificity. PLoS One. 2011; 6(1):e16245.
    View in: PubMed
  19. Frank NY, Schatton T, Kim S, Zhan Q, Wilson BJ, Ma J, Saab KR, Osherov V, Widlund HR, Gasser M, Waaga-Gasser AM, Kupper TS, Murphy GF, Frank MH. VEGFR-1 expressed by malignant melanoma-initiating cells is required for tumor growth. Cancer Res. 2011 Feb 15; 71(4):1474-85.
    View in: PubMed
  20. Clark RA, Shackelton JB, Watanabe R, Calarese A, Yamanaka K, Campbell JJ, Teague JE, Kuo HP, Hijnen D, Kupper TS. High-scatter T cells: a reliable biomarker for malignant T cells in cutaneous T-cell lymphoma. Blood. 2011 Feb 10; 117(6):1966-76.
    View in: PubMed
  21. Richmond J, Tuzova M, Parks A, Adams N, Martin E, Tawa M, Morrison L, Chaney K, Kupper TS, Curiel-Lewandrowski C, Cruikshank W. Interleukin-16 as a marker of Sézary syndrome onset and stage. J Clin Immunol. 2011 Feb; 31(1):39-50.
    View in: PubMed
  22. Campbell JJ, Clark RA, Watanabe R, Kupper TS. Sezary syndrome and mycosis fungoides arise from distinct T-cell subsets: a biologic rationale for their distinct clinical behaviors. Blood. 2010 Aug 5; 116(5):767-71.
    View in: PubMed
  23. Jiang X, Campbell JJ, Kupper TS. Embryonic trafficking of gammadelta T cells to skin is dependent on E/P selectin ligands and CCR4. Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7443-8.
    View in: PubMed
  24. van Geel NA, Mollet IG, De Schepper S, Tjin EP, Vermaelen K, Clark RA, Kupper TS, Luiten RM, Lambert J. First histopathological and immunophenotypic analysis of early dynamic events in a patient with segmental vitiligo associated with halo nevi. Pigment Cell Melanoma Res. 2010 Jun; 23(3):375-84.
    View in: PubMed
  25. Litvinov IV, Jones DA, Sasseville D, Kupper TS. Transcriptional profiles predict disease outcome in patients with cutaneous T-cell lymphoma. Clin Cancer Res. 2010 Apr 1; 16(7):2106-14.
    View in: PubMed
  26. Yamanaka KI, Kakeda M, Kitagawa H, Tsuda K, Akeda T, Kurokawa I, Gabazza EC, Kupper TS, Mizutani H. 1,24-Dihydroxyvitamin D3 (tacalcitol) prevents skin T-cell infiltration. Br J Dermatol. 2010 Jun; 162(6):1206-15.
    View in: PubMed
  27. Yamanaka K, Fuhlbrigge RC, Mizutani H, Kupper TS. Restoration of peripheral blood T cell repertoire complexity during remission in advanced cutaneous T cell lymphoma. Arch Dermatol Res. 2010 Aug; 302(6):453-9.
    View in: PubMed
  28. Liu L, Zhong Q, Tian T, Dubin K, Athale SK, Kupper TS. Epidermal injury and infection during poxvirus immunization is crucial for the generation of highly protective T cell-mediated immunity. Nat Med. 2010 Feb; 16(2):224-7.
    View in: PubMed
  29. Huang SJ, Hijnen D, Murphy GF, Kupper TS, Calarese AW, Mollet IG, Schanbacher CF, Miller DM, Schmults CD, Clark RA. Imiquimod enhances IFN-gamma production and effector function of T cells infiltrating human squamous cell carcinomas of the skin. J Invest Dermatol. 2009 Nov; 129(11):2676-85.
    View in: PubMed
  30. Bianchi T, Pincus LB, Wurbel MA, Rich BE, Kupper TS, Fuhlbrigge RC, Boes M. Maintenance of peripheral tolerance through controlled tissue homing of antigen-specific T cells in K14-mOVA mice. J Immunol. 2009 Apr 15; 182(8):4665-74.
    View in: PubMed
  31. Cheaib Z, Grandjean D, Kupper T, de Alencastro LF. Brominated flame retardants in fish of Lake Geneva (Switzerland). Bull Environ Contam Toxicol. 2009 Apr; 82(4):522-7.
    View in: PubMed
  32. Clark RA, Huang SJ, Murphy GF, Mollet IG, Hijnen D, Muthukuru M, Schanbacher CF, Edwards V, Miller DM, Kim JE, Lambert J, Kupper TS. Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells. J Exp Med. 2008 Sep 29; 205(10):2221-34.
    View in: PubMed
  33. Kimball AB, Kupper TS. Future perspectives/quo vadis psoriasis treatment? Immunology, pharmacogenomics, and epidemiology. Clin Dermatol. 2008 Sep-Oct; 26(5):554-61.
    View in: PubMed
  34. Tian T, Liu L, Freyschmidt EJ, Murphy GF, Kupper TS, Fuhlbrigge RC. Overexpression of IL-1alpha in skin differentially modulates the immune response to scarification with vaccinia virus. J Invest Dermatol. 2009 Jan; 129(1):70-8.
    View in: PubMed
  35. Kupper T, Bucheli TD, Brändli RC, Ortelli D, Edder P. Dissipation of pesticides during composting and anaerobic digestion of source-separated organic waste at full-scale plants. Bioresour Technol. 2008 Nov; 99(17):7988-94.
    View in: PubMed
  36. Bester K, Klasmeier J, Kupper T. Emissions of OTNE (Iso-E-super) - mass flows in sewage treatment plants. Chemosphere. 2008 May; 71(11):2003-10.
    View in: PubMed
  37. Schatton T, Murphy GF, Frank NY, Yamaura K, Waaga-Gasser AM, Gasser M, Zhan Q, Jordan S, Duncan LM, Weishaupt C, Fuhlbrigge RC, Kupper TS, Sayegh MH, Frank MH. Identification of cells initiating human melanomas. Nature. 2008 Jan 17; 451(7176):345-9.
    View in: PubMed
  38. Kupper T, de Alencastro LF, Gatsigazi R, Furrer R, Grandjean D, Tarradellas J. Concentrations and specific loads of brominated flame retardants in sewage sludge. Chemosphere. 2008 Apr; 71(6):1173-80.
    View in: PubMed
  39. Yamanaka K, Dimitroff CJ, Fuhlbrigge RC, Kakeda M, Kurokawa I, Mizutani H, Kupper TS. Vitamins A and D are potent inhibitors of cutaneous lymphocyte-associated antigen expression. J Allergy Clin Immunol. 2008 Jan; 121(1):148-157.e3.
    View in: PubMed
  40. Shin J, Monti S, Aires DJ, Duvic M, Golub T, Jones DA, Kupper TS. Lesional gene expression profiling in cutaneous T-cell lymphoma reveals natural clusters associated with disease outcome. Blood. 2007 Oct 15; 110(8):3015-27.
    View in: PubMed
  41. Weishaupt C, Munoz KN, Buzney E, Kupper TS, Fuhlbrigge RC. T-cell distribution and adhesion receptor expression in metastatic melanoma. Clin Cancer Res. 2007 May 1; 13(9):2549-56.
    View in: PubMed
  42. Brändli RC, Bucheli TD, Kupper T, Furrer R, Stahel WA, Stadelmann FX, Tarradellas J. Organic pollutants in compost and digestate. Part 1. Polychlorinated biphenyls, polycyclic aromatic hydrocarbons and molecular markers. J Environ Monit. 2007 May; 9(5):456-64.
    View in: PubMed
  43. Brändli RC, Kupper T, Bucheli TD, Zennegg M, Huber S, Ortelli D, Müller J, Schaffner C, Iozza S, Schmid P, Berger U, Edder P, Oehme M, Stadelmann FX, Tarradellas J. Organic pollutants in compost and digestate. Part 2. Polychlorinated dibenzo-p-dioxins, and -furans, dioxin-like polychlorinated biphenyls, brominated flame retardants, perfluorinated alkyl substances, pesticides, and other compounds. J Environ Monit. 2007 May; 9(5):465-72.
    View in: PubMed
  44. Brändli RC, Bucheli TD, Kupper T, Mayer J, Stadelmann FX, Tarradellas J. Fate of PCBs, PAHs and their source characteristic ratios during composting and digestion of source-separated organic waste in full-scale plants. Environ Pollut. 2007 Jul; 148(2):520-8.
    View in: PubMed
  45. Burkhardt M, Kupper T, Hean S, Haag R, Schmid P, Kohler M, Boller M. Biocides used in building materials and their leaching behavior to sewer systems. Water Sci Technol. 2007; 56(12):63-7.
    View in: PubMed
  46. Hirahara K, Liu L, Clark RA, Yamanaka K, Fuhlbrigge RC, Kupper TS. The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors. J Immunol. 2006 Oct 1; 177(7):4488-94.
    View in: PubMed
  47. Clark RA, Kupper TS. IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin. Blood. 2007 Jan 1; 109(1):194-202.
    View in: PubMed
  48. Liu L, Fuhlbrigge RC, Karibian K, Tian T, Kupper TS. Dynamic programming of CD8+ T cell trafficking after live viral immunization. Immunity. 2006 Sep; 25(3):511-20.
    View in: PubMed
  49. Figueiredo ML, Dayan S, Kim Y, McBride J, Kupper TS, Wong DT. Expression of cell-cycle regulator CDK2-associating protein 1 (p12CDK2AP1) in transgenic mice induces testicular and ovarian atrophy in vivo. Mol Reprod Dev. 2006 Aug; 73(8):987-97.
    View in: PubMed
  50. Clark RA, Kupper TS. Misbehaving macrophages in the pathogenesis of psoriasis. J Clin Invest. 2006 Aug; 116(8):2084-7.
    View in: PubMed
  51. Kupper T, Plagellat C, Brändli RC, de Alencastro LF, Grandjean D, Tarradellas J. Fate and removal of polycyclic musks, UV filters and biocides during wastewater treatment. Water Res. 2006 Aug; 40(14):2603-12.
    View in: PubMed
  52. Clark RA, Chong BF, Mirchandani N, Yamanaka K, Murphy GF, Dowgiert RK, Kupper TS. A novel method for the isolation of skin resident T cells from normal and diseased human skin. J Invest Dermatol. 2006 May; 126(5):1059-70.
    View in: PubMed
  53. Clark RA, Chong B, Mirchandani N, Brinster NK, Yamanaka K, Dowgiert RK, Kupper TS. The vast majority of CLA+ T cells are resident in normal skin. J Immunol. 2006 Apr 1; 176(7):4431-9.
    View in: PubMed
  54. Yamanaka K, Clark R, Dowgiert R, Hurwitz D, Shibata M, Rich BE, Hirahara K, Jones DA, Eapen S, Mizutani H, Kupper TS. Expression of interleukin-18 and caspase-1 in cutaneous T-cell lymphoma. Clin Cancer Res. 2006 Jan 15; 12(2):376-82.
    View in: PubMed
  55. Goddard DS, Yamanaka K, Kupper TS, Jones DA. Activation of neutrophils in cutaneous T-cell lymphoma. Clin Cancer Res. 2005 Dec 1; 11(23):8243-9.
    View in: PubMed
  56. Yamanaka K, Clark R, Rich B, Dowgiert R, Hirahara K, Hurwitz D, Shibata M, Mirchandani N, Jones DA, Goddard DS, Eapen S, Mizutani H, Kupper TS. Skin-derived interleukin-7 contributes to the proliferation of lymphocytes in cutaneous T-cell lymphoma. Blood. 2006 Mar 15; 107(6):2440-5.
    View in: PubMed
  57. Yamanaka K, Inaba T, Nomura E, Hurwitz D, Jones DA, Hakamada A, Isoda K, Kupper TS, Mizutani H. Basic fibroblast growth factor treatment for skin ulcerations in scleroderma. Cutis. 2005 Dec; 76(6):373-6.
    View in: PubMed
  58. Fuhlbrigge RC, King SL, Sackstein R, Kupper TS. CD43 is a ligand for E-selectin on CLA+ human T cells. Blood. 2006 Feb 15; 107(4):1421-6.
    View in: PubMed
  59. Clark RA, Yamanaka K, Bai M, Dowgiert R, Kupper TS. Human skin cells support thymus-independent T cell development. J Clin Invest. 2005 Nov; 115(11):3239-49.
    View in: PubMed
  60. Clark R, Kupper T. Old meets new: the interaction between innate and adaptive immunity. J Invest Dermatol. 2005 Oct; 125(4):629-37.
    View in: PubMed
  61. Inaba T, Yamanaka K, Asahi K, Omoto Y, Isoda K, Hurwitz D, Kupper TS, Mizutani H. Complete remission in a patient with angiosarcoma by the combination of OK-432, rhIL-2, and radiotherapy. Eur J Dermatol. 2005 Sep-Oct; 15(5):411-3.
    View in: PubMed
  62. Yamanaka K, Yawalkar N, Jones DA, Hurwitz D, Ferenczi K, Eapen S, Kupper TS. Decreased T-cell receptor excision circles in cutaneous T-cell lymphoma. Clin Cancer Res. 2005 Aug 15; 11(16):5748-55.
    View in: PubMed
  63. Plagellat C, Kupper T, Furrer R, de Alencastro LF, Grandjean D, Tarradellas J. Concentrations and specific loads of UV filters in sewage sludge originating from a monitoring network in Switzerland. Chemosphere. 2006 Feb; 62(6):915-25.
    View in: PubMed
  64. Mee JB, Antonopoulos C, Poole S, Kupper TS, Groves RW. Counter-regulation of interleukin-1alpha (IL-1alpha) and IL-1 receptor antagonist in murine keratinocytes. J Invest Dermatol. 2005 Jun; 124(6):1267-74.
    View in: PubMed
  65. Liu L, Xu Z, Fuhlbrigge RC, Peña-Cruz V, Lieberman J, Kupper TS. Vaccinia virus induces strong immunoregulatory cytokine production in healthy human epidermal keratinocytes: a novel strategy for immune evasion. J Virol. 2005 Jun; 79(12):7363-70.
    View in: PubMed
  66. Brändli RC, Bucheli TD, Kupper T, Furrer R, Stadelmann FX, Tarradellas J. Persistent organic pollutants in source-separated compost and its feedstock materials--a review of field studies. J Environ Qual. 2005 May-Jun; 34(3):735-60.
    View in: PubMed
  67. Plagellat C, Kupper T, de Alencastro LF, Grandjean D, Tarradellas J. Biocides in sewage sludge: quantitative determination in some Swiss wastewater treatment plants. Bull Environ Contam Toxicol. 2004 Nov; 73(5):794-801.
    View in: PubMed
  68. Berset JD, Kupper T, Etter R, Tarradellas J. Considerations about the enantioselective transformation of polycyclic musks in wastewater, treated wastewater and sewage sludge and analysis of their fate in a sequencing batch reactor plant. Chemosphere. 2004 Nov; 57(8):987-96.
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  69. Dayan S, Stashenko P, Niederman R, Kupper TS. Oral epithelial overexpression of IL-1alpha causes periodontal disease. J Dent Res. 2004 Oct; 83(10):786-90.
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  70. Adams AE, Zwicker J, Curiel C, Kadin ME, Falchuk KR, Drews R, Kupper TS. Aggressive cutaneous T-cell lymphomas after TNFalpha blockade. J Am Acad Dermatol. 2004 Oct; 51(4):660-2.
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  71. Friedman JS, Alpdogan O, van den Brink MR, Liu C, Hurwitz D, Boyd A, Kupper TS, Burakoff SJ. Increasing T-cell age reduces effector activity but preserves proliferative capacity in a murine allogeneic major histocompatibility complex-mismatched bone marrow transplant model. Biol Blood Marrow Transplant. 2004 Jul; 10(7):448-60.
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  72. Jones DA, Yawalkar N, Suh KY, Sadat S, Rich B, Kupper TS. Identification of autoantigens in psoriatic plaques using expression cloning. J Invest Dermatol. 2004 Jul; 123(1):93-100.
    View in: PubMed
  73. Rossi L, de Alencastro L, Kupper T, Tarradellas J. Urban stormwater contamination by polychlorinated biphenyls (PCBs) and its importance for urban water systems in Switzerland. Sci Total Environ. 2004 Apr 25; 322(1-3):179-89.
    View in: PubMed
  74. Kupper TS, Fuhlbrigge RC. Immune surveillance in the skin: mechanisms and clinical consequences. Nat Rev Immunol. 2004 Mar; 4(3):211-22.
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  75. Kupper T, Berset JD, Etter-Holzer R, Furrer R, Tarradellas J. Concentrations and specific loads of polycyclic musks in sewage sludge originating from a monitoring network in Switzerland. Chemosphere. 2004 Feb; 54(8):1111-20.
    View in: PubMed
  76. Chong BF, Murphy JE, Kupper TS, Fuhlbrigge RC. E-selectin, thymus- and activation-regulated chemokine/CCL17, and intercellular adhesion molecule-1 are constitutively coexpressed in dermal microvessels: a foundation for a cutaneous immunosurveillance system. J Immunol. 2004 Feb 1; 172(3):1575-81.
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  77. Kupper TS. Immunologic targets in psoriasis. N Engl J Med. 2003 Nov 20; 349(21):1987-90.
    View in: PubMed
  78. Dimitroff CJ, Kupper TS, Sackstein R. Prevention of leukocyte migration to inflamed skin with a novel fluorosugar modifier of cutaneous lymphocyte-associated antigen. J Clin Invest. 2003 Oct; 112(7):1008-18.
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  79. Hurwitz DJ, Pincus L, Kupper TS. Imiquimod: a topically applied link between innate and acquired immunity. Arch Dermatol. 2003 Oct; 139(10):1347-50.
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  80. Robert C, Klein C, Cheng G, Kogan A, Mulligan RC, von Andrian UH, Kupper TS. Gene therapy to target dendritic cells from blood to lymph nodes. Gene Ther. 2003 Aug; 10(17):1479-86.
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  81. Ferenczi K, Yawalkar N, Jones D, Kupper TS. Monitoring the decrease of circulating malignant T cells in cutaneous T-cell lymphoma during photopheresis and interferon therapy. Arch Dermatol. 2003 Jul; 139(7):909-13.
    View in: PubMed
  82. Yawalkar N, Ferenczi K, Jones DA, Yamanaka K, Suh KY, Sadat S, Kupper TS. Profound loss of T-cell receptor repertoire complexity in cutaneous T-cell lymphoma. Blood. 2003 Dec 1; 102(12):4059-66.
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  83. Kopp T, Lenz P, Bello-Fernandez C, Kastelein RA, Kupper TS, Stingl G. IL-23 production by cosecretion of endogenous p19 and transgenic p40 in keratin 14/p40 transgenic mice: evidence for enhanced cutaneous immunity. J Immunol. 2003 Jun 1; 170(11):5438-44.
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  84. Murphy JE, Morales RE, Scott J, Kupper TS. IL-1 alpha, innate immunity, and skin carcinogenesis: the effect of constitutive expression of IL-1 alpha in epidermis on chemical carcinogenesis. J Immunol. 2003 Jun 1; 170(11):5697-703.
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  85. Ferenczi K, Fuhlbrigge RC, Pinkus J, Pinkus GS, Kupper TS. Increased CCR4 expression in cutaneous T cell lymphoma. J Invest Dermatol. 2002 Dec; 119(6):1405-10.
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  86. Fuhlbrigge RC, King SL, Dimitroff CJ, Kupper TS, Sackstein R. Direct real-time observation of E- and P-selectin-mediated rolling on cutaneous lymphocyte-associated antigen immobilized on Western blots. J Immunol. 2002 Jun 1; 168(11):5645-51.
    View in: PubMed
  87. Pendl GG, Robert C, Steinert M, Thanos R, Eytner R, Borges E, Wild MK, Lowe JB, Fuhlbrigge RC, Kupper TS, Vestweber D, Grabbe S. Immature mouse dendritic cells enter inflamed tissue, a process that requires E- and P-selectin, but not P-selectin glycoprotein ligand 1. Blood. 2002 Feb 1; 99(3):946-56.
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  88. Armerding D, Fuhlbrigge RC, Kieffer JD, Kupper TS. Tonsillar B cells do not express PSGL-1, but a significant fraction displays the cutaneous lymphocyte antigen and exhibits effective E- and P-selectin ligand activity. Int Arch Allergy Immunol. 2001 Sep; 126(1):78-90.
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  89. Kopp T, Kieffer JD, Rot A, Strommer S, Stingl G, Kupper TS. Inflammatory skin disease in K14/p40 transgenic mice: evidence for interleukin-12-like activities of p40. J Invest Dermatol. 2001 Sep; 117(3):618-26.
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  90. Kieffer JD, Fuhlbrigge RC, Armerding D, Robert C, Ferenczi K, Camphausen RT, Kupper TS. Neutrophils, monocytes, and dendritic cells express the same specialized form of PSGL-1 as do skin-homing memory T cells: cutaneous lymphocyte antigen. Biochem Biophys Res Commun. 2001 Jul 20; 285(3):577-87.
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  91. Rich BE, Kupper TS. Cytokines: IL-20 - a new effector in skin inflammation. Curr Biol. 2001 Jul 10; 11(13):R531-4.
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  92. Cheng SX, Kupper T. A new rexinoid for cutaneous t-cell lymphoma. Arch Dermatol. 2001 May; 137(5):649-52.
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  93. Rossiter H, Beissert S, Mayer C, Schön MP, Wienrich BG, Tschachler E, Kupper TS. Targeted expression of bcl-2 to murine basal epidermal keratinocytes results in paradoxical retardation of ultraviolet- and chemical-induced tumorigenesis. Cancer Res. 2001 May 1; 61(9):3619-26.
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  94. Kupper TS. T cells, immunosurveillance, and cutaneous immunity. J Dermatol Sci. 2000 Dec; 24 Suppl 1:S41-5.
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  95. Carcamo AS, Fuhlbrigge RC, Hong R, Gullans SR, Kupper TS. Comparative analysis of the global transcriptional profile of human skin-homing memory T lymphocytes vs. non-skin homing memory and naive T lymphocytes J Invest Dermatol. 2000 Aug; 115(2):332.
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  96. Yamanaka K, Tanaka M, Tsutsui H, Kupper TS, Asahi K, Okamura H, Nakanishi K, Suzuki M, Kayagaki N, Black RA, Miller DK, Nakashima K, Shimizu M, Mizutani H. Skin-specific caspase-1-transgenic mice show cutaneous apoptosis and pre-endotoxin shock condition with a high serum level of IL-18. J Immunol. 2000 Jul 15; 165(2):997-1003.
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  97. Müller-Röver S, Rossiter H, Paus R, Handjiski B, Peters EM, Murphy JE, Mecklenburg L, Kupper TS. Overexpression of Bcl-2 protects from ultraviolet B-induced apoptosis but promotes hair follicle regression and chemotherapy-induced alopecia. Am J Pathol. 2000 Apr; 156(4):1395-405.
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  98. Murphy JE, Robert C, Kupper TS. Interleukin-1 and cutaneous inflammation: a crucial link between innate and acquired immunity. J Invest Dermatol. 2000 Mar; 114(3):602-8.
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  99. Frieling UM, Schaumberg DA, Kupper TS, Muntwyler J, Hennekens CH. A randomized, 12-year primary-prevention trial of beta carotene supplementation for nonmelanoma skin cancer in the physician's health study. Arch Dermatol. 2000 Feb; 136(2):179-84.
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  100. Robert C, Kupper TS. Inflammatory skin diseases, T cells, and immune surveillance. N Engl J Med. 1999 Dec 9; 341(24):1817-28.
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  101. Robert C, Kupper TS. Inflammatory skin disease, T cells, and immune surveillance. N Engl J Med. Review. 1999; 9;341(24):1817-28.
  102. Müller-Röver S, Rossiter H, Lindner G, Peters EM, Kupper TS, Paus R. Hair follicle apoptosis and Bcl-2. J Investig Dermatol Symp Proc. 1999 Dec; 4(3):272-7.
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  103. Armerding D, Kupper TS. Functional cutaneous lymphocyte antigen can be induced in essentially all peripheral blood T lymphocytes. Int Arch Allergy Immunol. 1999 Jul; 119(3):212-22.
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  104. Robert C, Fuhlbrigge RC, Kieffer JD, Ayehunie S, Hynes RO, Cheng G, Grabbe S, von Andrian UH, Kupper TS. Interaction of dendritic cells with skin endothelium: A new perspective on immunosurveillance. J Exp Med. 1999 Feb 15; 189(4):627-36.
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  105. Williams IR, Rich B, Kupper TS. Cytokines and Chemokines. Dermatology in General Medicine, T. Fitzpatrick et al, Ed. 1999.
  106. Rauschmayr-Kopp T, Williams IR, Borriello F, Sharpe AH, Kupper TS. Distinct roles for B7 costimulation in contact hypersensitivity and humoral immune responses to epicutaneous antigen. Eur J Immunol. 1998 Dec; 28(12):4221-7.
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  107. Freeman GJ, Cardoso AA, Boussiotis VA, Anumanthan A, Groves RW, Kupper TS, Clark EA, Nadler LM. The BB1 monoclonal antibody recognizes both cell surface CD74 (MHC class II-associated invariant chain) as well as B7-1 (CD80), resolving the question regarding a third CD28/CTLA-4 counterreceptor. J Immunol. 1998 Sep 15; 161(6):2708-15.
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  108. Mizutani H, Ohmoto Y, Kupper TS, Shimizu M. Endogenous neutralizing anti-IL-1 alpha autoantibodies in inflammatory skin diseases: possible natural inhibitor for over expressed epidermal IL-1. J Dermatol Sci. 1998 May; 20(1):63-71.
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  109. Dubin DB, Hurowitz JC, Brettler D, Bernhard JD, Kadin ME, Wallace JE, Woda B, Pihan G, Kupper TS, Harrist TJ. Adnexotropic T-cell lymphoma presenting with generalized anhidrosis, progressive alopecia, pruritus, and Sjögren's syndrome. J Am Acad Dermatol. 1998 Mar; 38(3):493-7.
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  110. Kupper TS, SECTION EDITOR. DERMATOLOGY. Principles of Molecular Medicine, L Jameson, Ed. 1998.
  111. Nghiem P, Kupper TS. Cutaneous Oncology: Basal and Squamous Cell Carcinomas. Principles of Molecular Medicine, L. Jameson, Ed. 1998.
  112. Lee RT, Briggs WH, Cheng GC, Rossiter HB, Libby P, Kupper T. Mechanical deformation promotes secretion of IL-1 alpha and IL-1 receptor antagonist. J Immunol. 1997 Nov 15; 159(10):5084-8.
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  113. Fuhlbrigge RC, Kieffer JD, Armerding D, Kupper TS. Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells. Nature. 1997 Oct 30; 389(6654):978-81.
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  114. Williams IR, Rawson EA, Manning L, Karaoli T, Rich BE, Kupper TS. IL-7 overexpression in transgenic mouse keratinocytes causes a lymphoproliferative skin disease dominated by intermediate TCR cells: evidence for a hierarchy in IL-7 responsiveness among cutaneous T cells. J Immunol. 1997 Sep 15; 159(6):3044-56.
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  115. Ayehunie S, Garcia-Zepeda EA, Hoxie JA, Horuk R, Kupper TS, Luster AD, Ruprecht RM. Human immunodeficiency virus-1 entry into purified blood dendritic cells through CC and CXC chemokine coreceptors. Blood. 1997 Aug 15; 90(4):1379-86.
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  116. Rauschmayr T, Groves RW, Kupper TS. Keratinocyte expression of the type 2 interleukin 1 receptor mediates local and specific inhibition of interleukin 1-mediated inflammation. Proc Natl Acad Sci U S A. 1997 May 27; 94(11):5814-9.
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  117. Rossiter H, Alono R, Kupper TS. Selectins, T-cell rolling andn inflammation. Mol Med Today. Review. 1997; 3(5):214-22.
  118. Rossiter H, Alon R, Kupper TS. Selectins, T-cell rolling and inflammation. Mol Med Today. 1997 May; 3(5):214-22.
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  119. Mizutani H, Ohyanagi S, Umeda Y, Shimizu M, Kupper TS. Loss of cutaneous delayed hypersensitivity reactions in nevus anemicus. Evidence for close concordance of cutaneous delayed hypersensitivity and endothelial E-selectin expression. Arch Dermatol. 1997 May; 133(5):617-20.
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  120. Compton CC, Kupper TS, Nadire KB. HIV-infected Langerhans cells constitute a significant proportion of the epidermal Langerhans cell population throughout the course of HIV disease. J Invest Dermatol. 1996 Dec; 107(6):822-6.
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  121. Kupper TS. The utility of transgenic mouse models in the study of cutaneous immunology and inflammation. J Dermatol. 1996 Nov; 23(11):741-5.
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  122. Kupper TS. The Utility of transgenic mouse models in the study of cutaneous. J Dermatol. Review. 1996; 23(11):741-5.
  123. Groves RW, Rauschmayr T, Nakamura K, Sarkar S, Williams IR, Kupper TS. Inflammatory and hyperproliferative skin disease in mice that express elevated levels of the IL-1 receptor (type I) on epidermal keratinocytes. Evidence that IL-1-inducible secondary cytokines produced by keratinocytes in vivo can cause skin disease. J Clin Invest. 1996 Jul 15; 98(2):336-44.
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  124. Williams IR, Ort RJ, Daley D, Manning L, Karaoli T, Barnhill RL, Kupper TS. Constitutive expression of B7-1 (CD80) on mouse keratinocytes does not prevent development of chemically induced skin papillomas and carcinomas. J Immunol. 1996 May 1; 156(9):3382-8.
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  125. Groves R, Kupper TS. Leukocyte recruitment in cutaneous inflammation. Leukocyte Recruitment in Inflammatory Disease. 1996.
  126. Williams IR, Kupper TS. Immunity at the surface: homeostatic mechanisms of the skin immune system. Life Sci. 1996; 58(18):1485-507.
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  127. Williams IR, Kupper TS. Immunity at the surface: homeostatic mechanisms of the skin immune system. Life Sci. Review. 1996; 58(18):1485-507.
  128. Kieffer JD, Plopper G, Ingber DE, Hartwig JH, Kupper TS. Direct binding of F actin to the cytoplasmic domain of the alpha 2 integrin chain in vitro. Biochem Biophys Res Commun. 1995 Dec 14; 217(2):466-74.
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  129. Groves RW, Mizutani H, Kieffer JD, Kupper TS. Inflammatory skin disease in transgenic mice that express high levels of interleukin 1 alpha in basal epidermis. Proc Natl Acad Sci U S A. 1995 Dec 5; 92(25):11874-8.
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  130. Nakamura K, Williams IR, Kupper TS. Keratinocyte-derived monocyte chemoattractant protein 1 (MCP-1): analysis in a transgenic model demonstrates MCP-1 can recruit dendritic and Langerhans cells to skin. J Invest Dermatol. 1995 Nov; 105(5):635-43.
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  131. Ayehunie S, Groves RW, Bruzzese AM, Ruprecht RM, Kupper TS, Langhoff E. Acutely infected Langerhans cells are more efficient than T cells in disseminating HIV type 1 to activated T cells following a short cell-cell contact. AIDS Res Hum Retroviruses. 1995 Aug; 11(8):877-84.
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  132. Kupper TS, Groves RW. The interleukin-1 axis and cutaneous inflammation. J Invest Dermatol. 1995 Jul; 105(1 Suppl):62S-66S.
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  133. Groves RW, Giri J, Sims J, Dower SK, Kupper TS. Inducible expression of type 2 IL-1 receptors by cultured human keratinocytes. Implications for IL-1-mediated processes in epidermis. J Immunol. 1995 Apr 15; 154(8):4065-72.
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  134. Kupper TS. Adhesion molecules in scleroderma: collagen binding integrins. Int Rev Immunol. 1995; 12(2-4):217-25.
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  135. Williams IR, Ort RJ, Kupper TS. Keratinocyte expression of B7-1 in transgenic mice amplifies the primary immune response to cutaneous antigens. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):12780-4.
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  136. Alon R, Rossiter H, Wang X, Springer TA, Kupper TS. Distinct cell surface ligands mediate T lymphocyte attachment and rolling on P and E selectin under physiological flow. J Cell Biol. 1994 Dec; 127(5):1485-95.
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  137. Groves RW, Sherman L, Mizutani H, Dower SK, Kupper TS. Detection of interleukin-1 receptors in human epidermis. Induction of the type II receptor after organ culture and in psoriasis. Am J Pathol. 1994 Nov; 145(5):1048-56.
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  138. Williams IR, Kupper TS. Epidermal expression of intercellular adhesion molecule 1 is not a primary inducer of cutaneous inflammation in transgenic mice. Proc Natl Acad Sci U S A. 1994 Oct 11; 91(21):9710-4.
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  139. Mizutani H, Roswit W, Hemperly J, Lawley T, Compton C, Swerlick R, Kupper TS. Human dermal microvascular endothelial cells express the 140-kD isoform of neural cell adhesion molecule. Biochem Biophys Res Commun. 1994 Aug 30; 203(1):686-93.
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  140. Xu H, Gonzalo JA, St Pierre Y, Williams IR, Kupper TS, Cotran RS, Springer TA, Gutierrez-Ramos JC. Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice. J Exp Med. 1994 Jul 1; 180(1):95-109.
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  141. Ayehunie S, Bruzzese AM, Groves RW, Kupper TS, Langhoff E. HIV-1 transmission by mucosal langerhans cells, blood dendritic cells, and monocytes in vitro. Reg. Immunol. 1994; 6:1-7.
  142. Groves RG, Sherman L, Dower S, Kupper TS. Localization of functional IL-1 receptors in human skin: increased expression after organ culture and in psoriasis. Am J. Path. 1994; 145:1048-1056.
  143. Alon R, Rossiter H, Springer T, Kupper TS. Rolling of T lymphocytes on P and E Selectins under physiological flow conditions is mediated by distinct cell surface ligands. J. Cell. Biol. 1994; 127:1485-1495.
  144. Rossiter H, van Reijsen F, Mudde GC, Kalthoff F, Bruijnzeel-Koomen CA, Picker LJ, Kupper TS. Skin disease-related T cells bind to endothelial selectins: expression of cutaneous lymphocyte antigen (CLA) predicts E-selectin but not P-selectin binding. Eur J Immunol. 1994 Jan; 24(1):205-10.
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  145. Kupper TS. Immunity and Inflmmation in Cutaneous Tissues. In Sampter's Immunolgical Diseases, E. Unanue, Ed. 1994.
  146. Kupper TS, Ferguson TA. A potential pathophysiologic role for alpha 2 beta 1 integrin in human eye diseases involving vitreoretinal traction. FASEB J. 1993 Nov; 7(14):1401-6.
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  147. Peterseim UM, Sarkar SN, Kupper TS. Production of IL-3 by non-transformed primary neonatal murine keratinocytes: evidence for constitutive IL-3 gene expression in neonatal epidermis. Cytokine. 1993 May; 5(3):240-9.
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  148. Ferguson TA, Kupper TS. Antigen-independent processes in antigen-specific immunity. A role for alpha 4 integrin. J Immunol. 1993 Feb 15; 150(4):1172-82.
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  149. Buchsbaum ME, Kupper TS, Murphy GF. Differential induction of intercellular adhesion molecule-1 in human skin by recombinant cytokines. J Cutan Pathol. 1993 Feb; 20(1):21-7.
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  150. Kupper TS. The role of cytokines and adhesion molecules in inflammatory skin disease. In Cytokines: Clinical Applications, J. Oppenheim, A. Gearing , ed. 1993.
  151. Kupper TS. The second decade of epidermal cytokins: an overview. In Epidermal Growth Factors and Cytokines, T. Luger and T. Schwartz, Eds. 1993.
  152. Kupper TS. "Adhesion molecules, matrix, and cytokines: intregration during leukocyte migration". Dermatology in General Medicine, T. Fitzpatrick et al. 1993.
  153. Kupper TS. "The role of cytokines and adhesion molecules in inflammatory skin diseasae". Cytokines: Clinical Applications, J. Oppenheim, A. Gearing, Ed. 1993; New York.
  154. Turksen K, Kupper T, Degenstein L, Williams I, Fuchs E. Interleukin 6: insights to its function in skin by overexpression in transgenic mice. Proc Natl Acad Sci U S A. 1992 Jun 1; 89(11):5068-72.
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  155. Chan BM, Kassner PD, Schiro JA, Byers HR, Kupper TS, Hemler ME. Distinct cellular functions mediated by different VLA integrin alpha subunit cytoplasmic domains. Cell. 1992 Mar 20; 68(6):1051-60.
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  156. Turksen K, Kupper TS, Degenstein L, Williams I, Sarkar S, Fuchs E. IL-6 Insights to its function in skin by expression in transgenic mice. Proc. Natl, Acad. Sci. 1992; 89:5068-72.
  157. Schiro JA, Chan BM, Roswit WT, Kassner PD, Pentland AP, Hemler ME, Eisen AZ, Kupper TS. Integrin alpha 2 beta 1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells. Cell. 1991 Oct 18; 67(2):403-10.
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  158. Mizutani H, Schechter N, Lazarus G, Black RA, Kupper TS. Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase. J Exp Med. 1991 Oct 1; 174(4):821-5.
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  159. Ferguson TA, Mizutani H, Kupper TS. Two integrin-binding peptides abrogate T cell-mediated immune responses in vivo. Proc Natl Acad Sci U S A. 1991 Sep 15; 88(18):8072-6.
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  160. Birchall N, Orlow SJ, Kupper T, Pawelek J. Interactions between ultraviolet light and interleukin-1 on MSH binding in both mouse melanoma and human squamous carcinoma cells. Biochem Biophys Res Commun. 1991 Mar 29; 175(3):839-45.
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  161. Mizutani H, Black R, Kupper TS. Human keratinocytes produce but do not process pro-interleukin-1 (IL-1) beta. Different strategies of IL-1 production and processing in monocytes and keratinocytes. J Clin Invest. 1991 Mar; 87(3):1066-71.
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  162. Baker CC, Niven-Fairchild AT, Yamada A, Caragnano CL, Kupper TS. Macrophage antigen presentation and interleukin 1 production after cecal ligation and puncture in C3H/HeN and C3H/HeJ mice. Arch Surg. 1991 Feb; 126(2):253-7; discussion 257-8.
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  163. Baker CC, Niven-Fairchild T, Caragnano C, Kupper TS. Outcome following femur fracture and subsequent cecal ligation and puncture in endotoxin-sensitive (C3H/HeN) and endotoxin-resistant (C3H/HeJ) mice. J Surg Res. 1991 Feb; 50(2):170-4.
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  164. Mizutani H, Mizutani T, Okada H, Kupper TS, Shimizu M. Round fingerpad sign: an early sign of scleroderma. J Am Acad Dermatol. 1991 Jan; 24(1):67-9.
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  165. Black R, Kronheim S, Sleath P, Greenstreet T, Virca GD, March C, Kupper T. The proteolytic activation of interleukin-1 beta. Agents Actions Suppl. 1991; 35:85-9.
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  166. Black R, Kronheim S, Sleath P, Greenstreet T, Vica GD, March C, Kupper TS. The protelolyctic activation of interleukin-1 beta. Agents and Actions. 1991; 35:85-9.
  167. Pawelek J, Orlow S, Kupper TS, Birchall N. Recombinant human IL-1 alpha induces melanocyte-stimulating homone (MSH) receptor expression and enhances MSH-mediated melnaonogenesis. Biochem. Biophys. Res. Comm. 1991; 175:839.
  168. Schiro JA, Kupper TS. Cutaneous eruptions during GM-CSF infusion. Clues for cytokine biology. Arch Dermatol. 1991 Jan; 127(1):110-2.
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  169. Kupper TS. The role of epidermal cytokines in cutaneous immune and inflammatory reactions. Pharmacology and the Skin, Basel, Karger. 1991; 4:37-31.
  170. Kupper TS. Immune and inflammatory processes in cutaneous tissues. Mechanisms and speculations. J Clin Invest. 1990 Dec; 86(6):1783-9.
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  171. Galy AH, Dinarello CA, Kupper TS, Kameda A, Hadden JW. Effects of cytokines on human thymic epithelial cells in culture. II. Recombinant IL 1 stimulates thymic epithelial cells to produce IL6 and GM-CSF. Cell Immunol. 1990 Aug; 129(1):161-75.
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  172. Kupper TS. The activated keratinocyte: a model for inducible cytokine production by non-bone marrow-derived cells in cutaneous inflammatory and immune responses. J Invest Dermatol. 1990 Jun; 94(6 Suppl):146S-150S.
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  173. Dower SK, Qwarnstrom EE, Page RC, Blanton RA, Kupper TS, Raines E, Ross R, Sims JE. Biology of the interleukin-1 receptor. J Invest Dermatol. 1990 Jun; 94(6 Suppl):68S-73S.
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  174. Kupper TS,. "The Role of Epidermal Cytokines". The Immunophysiology of Cells and Cytokines, E. Shevach and J. Oppenheim, Ed. 1990.
  175. Kupper TS. Mechanisms of cutaneous inflammation. Interactions between epidermal cytokines, adhesion molecules, and leukocytes. Arch Dermatol. 1989 Oct; 125(10):1406-12.
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  176. Grossman RM, Krueger J, Yourish D, Granelli-Piperno A, Murphy DP, May LT, Kupper TS, Sehgal PB, Gottlieb AB. Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes. Proc Natl Acad Sci U S A. 1989 Aug; 86(16):6367-71.
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  177. Mizutani H, May LT, Sehgal PB, Kupper TS. Synergistic interactions of IL-1 and IL-6 in T cell activation. Mitogen but not antigen receptor-induced proliferation of a cloned T helper cell line is enhanced by exogenous IL-6. J Immunol. 1989 Aug 1; 143(3):896-901.
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  178. Schneider EG, Armant DR, Kupper TS, Polan ML. Absence of a direct effect of recombinant interleukins and cultured peritoneal macrophages on early embryonic development in the mouse. Biol Reprod. 1989 Apr; 40(4):825-33.
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  179. Kupper TS. Production of cytokines by epithelial tissues. A new model for cutaneous inflammation. Am J Dermatopathol. 1989 Feb; 11(1):69-73.
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  180. Blanton RA, Kupper TS, McDougall JK, Dower S. Regulation of interleukin 1 and its receptor in human keratinocytes. Proc Natl Acad Sci U S A. 1989 Feb; 86(4):1273-7.
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  181. Kupper TS, Min K, Sehgal P, Mizutani H, Birchall N, Ray A, May L. Production of IL-6 by keratinocytes. Implications for epidermal inflammation and immunity. Ann N Y Acad Sci. 1989; 557:454-64; discussion 464-5.
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  182. Horowitz MC, Coleman DL, Flood PM, Kupper TS, Jilka RL. Parathyroid hormone and lipopolysaccharide induce murine osteoblast-like cells to secrete a cytokine indistinguishable from granulocyte-macrophage colony-stimulating factor. J Clin Invest. 1989 Jan; 83(1):149-57.
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  183. Kupper TS. Mechanisms of cutaneous inflammation. Interactions between epidermal cytokins, adhesion molecules, and leukocytes. Ach Dermatol. 1989; 125(10):1406-12.
  184. Kupper TS. "The Immunology of Skin". The Immune Consequence of Shock, Trauma and Sepsis, E. Faist, D. Green and J. Ninnemann, Eds. 1989.
  185. Kupper TS, Lee F, Birchall N, Clark S, Dower S. Interleukin 1 binds to specific receptors on human keratinocytes and induces granulocyte macrophage colony-stimulating factor mRNA and protein. A potential autocrine role for interleukin 1 in epidermis. J Clin Invest. 1988 Nov; 82(5):1787-92.
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  186. Kupper TS, Lee F, Coleman D, Chodakewitz J, Flood P, Horowitz M. Keratinocyte derived T-cell growth factor (KTGF) is identical to granulocyte macrophage colony stimulating factor (GM-CSF). J Invest Dermatol. 1988 Aug; 91(2):185-8.
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  187. Jacobson BK, Cuono CB, Kupper TS, Baker CC. Immunologic alterations following excisional wounding and immediate repair with syngeneic or allogeneic skin grafts. J Burn Care Rehabil. 1988 Jul-Aug; 9(4):354-8.
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  188. Breslin RJ, Barbul A, Kupper TS, Knud-Hansen JP, Wasserkrug HL, Efron G. Generation of an anti-interleukin 2 factor in healing wounds. Arch Surg. 1988 Mar; 123(3):305-8.
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  189. Chodakewitz JA, Kupper TS, Coleman DL. Keratinocyte-derived granulocyte/macrophage colony-stimulating factor induces DNA synthesis by peritoneal macrophages. J Immunol. 1988 Feb 1; 140(3):832-6.
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  190. Jacobson B, Kupper TS, Baker CC, Cuono C. . The effect of immediate excision and autografting of allografting on immune responses after burn injury. J. Burn Care Rehab. 1988; 9:354.
  191. Kupper TS, Lee F, Flood P, Horowitz M, Coleman D. Hematopoietic cytokines produced by murine and human keratinocytes. Ann. NY. Acad. Sci. 1988; 548:283.
  192. McGuire J, Langdon R, Birchall N, Kupper T. Interleukin-1 alpha mRNA induced by cycloheximide PMA, and retinoic acid is reduced by dexamethasone in PAM-212 keratinocytes. Ann N Y Acad Sci. 1988; 548:283-90.
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  193. Kupper TS. Interleukin 1 and other keratinocyte cytokines: molecular and functional characterization. Adv. Derm. 1988; 3:293.
  194. Kupper TS. Interleukin 1 and other human keratinocyte cytokines: molecular and functional characterization. Adv Dermatol. 1988; 3:293-307.
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  195. Kupper TS, Horowitz M, Birchall N, Mizutani H, Coleman D, McGuire J, Flood P, Dower S, Lee F. Hematopoietic, lymphopoietic, and proinflammatory cytokines produced by human and murine keratinocytes. Ann N Y Acad Sci. 1988; 548:262-70.
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  196. McGuire J, Birchall N, Langdon B, Kupper TS. . Regulation of interleukin 1 mRNA in keratinocytes by glucocorticosteroids. Ann. NY. Acad. Sci. 1988; 548:283.
  197. Kupper TS, Edelson RL. The role of cytokines in the pathophysiology of T cell mediated skin disease. J Dermatol. 1987 Dec; 14(6):517-23.
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  198. Baker CC, Yamada AH, Faist E, Kupper TS. Interleukin-1 and T cell function following injury. J Burn Care Rehabil. 1987 Nov-Dec; 8(6):503-8.
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  199. Kupper TS, Chua AO, Flood P, McGuire J, Gubler U. Interleukin 1 gene expression in cultured human keratinocytes is augmented by ultraviolet irradiation. J Clin Invest. 1987 Aug; 80(2):430-6.
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  200. Kupper T, Flood P, Coleman D, Horowitz M. Growth of an interleukin 2/interleukin 4-dependent T cell line induced by granulocyte-macrophage colony-stimulating factor (GM-CSF). J Immunol. 1987 Jun 15; 138(12):4288-92.
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  201. Kupper T, Horowitz M, Lee F, Robb R, Flood PM. Autocrine growth of T cells independent of interleukin 2: identification of interleukin 4 (IL 4, BSF-1) as an autocrine growth factor for a cloned antigen-specific helper T cell. J Immunol. 1987 Jun 15; 138(12):4280-7.
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  202. Coleman DL, Kupper TS, Flood PM, Fultz CC, Horowitz MC. Characterization of a keratinocyte-derived T cell growth factor distinct from interleukin 2 and B cell stimulatory factor 1. J Immunol. 1987 May 15; 138(10):3314-8.
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  203. Stephan RN, Kupper TS, Geha AS, Baue AE, Chaudry IH. Hemorrhage without tissue trauma produces immunosuppression and enhances susceptibility to sepsis. Arch Surg. 1987 Jan; 122(1):62-8.
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  204. Goldminz D, Kupper TS, McGuire J. Keratinocyte membrane-associated epidermal cell-derived thymocyte-activating factor (ETAF). J Invest Dermatol. 1987 Jan; 88(1):97-100.
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  205. Kupper TS, Ballard DW, Chua AO, McGuire JS, Flood PM, Horowitz MC, Langdon R, Lightfoot L, Gubler U. Human keratinocytes contain mRNA indistinguishable from monocyte interleukin 1 alpha and beta mRNA. Keratinocyte epidermal cell-derived thymocyte-activating factor is identical to interleukin 1. J Exp Med. 1986 Dec 1; 164(6):2095-100.
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  206. Kupper TS, McGuire J. Hydrocortisone reduces both constitutive and UV-elicited release of epidermal thymocyte activating factor (ETAF) by cultured keratinocytes. J Invest Dermatol. 1986 Nov; 87(5):570-3.
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  207. Faist E, Kupper TS, Baker CC, Chaudry IH, Dwyer J, Baue AE. Depression of cellular immunity after major injury. Its association with posttraumatic complications and its reversal with immunomodulation. Arch Surg. 1986 Sep; 121(9):1000-5.
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  208. Kupper TS, Deitch EA, Baker CC, Wong WC. The human burn wound as a primary source of interleukin-1 activity. Surgery. 1986 Aug; 100(2):409-15.
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  209. Kupper TS, Coleman DL, McGuire J, Goldminz D, Horowitz MC. Keratinocyte-derived T-cell growth factor: a T-cell growth factor functionally distinct from interleukin 2. Proc Natl Acad Sci U S A. 1986 Jun; 83(12):4451-5.
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  210. Kupper TS, Green DR, Durum SK, Baker CC. Defective antigen presentation to a cloned T helper cell by macrophages from burned mice can be restored with interleukin-1. Surgery. 1985 Aug; 98(2):199-206.
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  211. Kupper TS, Baker CC, Ferguson TA, Green DR. A burn induced Ly-2 suppressor T cell lowers resistance to bacterial infection. J Surg Res. 1985 Jun; 38(6):606-12.
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  212. Baker CC, Kupper TS. The role of endotoxin in intra-abdominal sepsis. Surg Forum. 1985; 36:68.
  213. Kupper TS, Green DR. In vivo exposure to IL-1 or ETAF causes a loss of antigen presenting cell function. Brit J. Rheumatol. 1985; 24:98.
  214. Kupper TS, Green DR. Immunoregulation after thermal injury: sequential appearance of I-J+, Ly-1 T suppressor inducer cells and Ly-2 T suppressor effector cells following thermal trauma in mice. J Immunol. 1984 Dec; 133(6):3047-53.
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  215. Fusi S, Kupper TS, Green DR, Ariyan S. Reversal of postburn immunosuppression by the administration of vitamin A. Surgery. 1984 Aug; 96(2):330-5.
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  216. Kupper TS, Green DR, Chaudry IH, Fox A, Baue AE. A cyclophosphamide-sensitive suppressor T cell circuit induced by thermal injury. Surgery. 1984 Jun; 95(6):699-706.
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  217. Chaudry IH, Schleck S, Clemens MG, Kupper TE, Baue AE. Altered hepatocellular active transport. An early change in peritonitis. Arch Surg. 1982 Feb; 117(2):151-7.
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  218. Chaudry IH, Kupper TS, Schleck S, Clemens MG, Baue AE. Impairment of reticuloendothelial function following thermal injury and its restoration with ATP-MgCl2 administration. Circ Shock. 1982; 9(3):297-305.
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  219. Kupper TS, Green DR, Chaudry IH, Clemens MG, Baue AE. . Restoration of the immune response following burn injury with low doese cyclophosphamide. Surg. Forum. 1981; 32:60.
  220. Kupper, TS. Studies on the induction and reversal of depressed immunity following burn injury. 1981.
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